TWAS hub - RPS6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1100	0.0390	9.5e-04	0.014	NA	0.053	NA	0.041	2.5e-02	NA	3.5e-05	NA	2.5e-04
2	GTEx	Colon Transverse	0.1310	0.0500	5.1e-03	0.038	NA	0.006	NA	0.012	6.5e-03	NA	1.5e-01	NA	8.6e-02
3	GTEx	Esophagus Muscularis	0.1370	0.0470	1.2e-03	0.005	NA	-0.001	NA	-0.001	1.6e-01	NA	4.1e-01	NA	3.7e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.1141	0.0312	7.5e-06	0.077	0.038	0.065	0.069	0.074	3.5e-10	1e-05	9.0e-09	3.3e-09	8.0e-10
5	TCGA	Lung Adenocarcinoma	0.0672	0.0394	9.7e-03	0.005	0.000	0.003	NA	0.002	7.5e-02	3e-01	1.2e-01	NA	1.8e-01
6	TCGA	Thyroid Carcinoma	0.0320	0.0180	5.1e-03	0.010	0.016	0.003	NA	0.006	3.1e-02	1e-02	1.6e-01	NA	7.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
High cholesterol (Self-reported)	8.8	15.6	20.7	-4.1	-4.1	-3.0	-4.6	-4.0	-3.7
Cardiovascular Disease	7.4	24.3	35.5	-5.0	-5.1	-3.7	-6.0	-4.5	-5.0
Medication: Cholesterol lowering	7.2	11.2	14.1	-3.1	-2.8	-3.2	-3.8	-3.5	-3.5
LDL Cholesterol	6.6	10.4	18.2	-2.7	-4.3	-2.0	-4.1	-3.2	-2.4
Medication for cholesterol	4.6	7.0	12.1	2.0	3.5	0.9	3.4	2.4	2.9
Cholesterol lowering medication	4.3	6.4	11.7	-1.9	-3.4	-1.2	-3.4	-2.3	-2.2
Systolic Blood Pressure	3.8	19.0	23.7	-4.5	-3.9	-3.7	-4.9	-4.2	-4.9
Time employed in main current job	3.4	3.9	6.8	2.4	1.8	0.4	2.6	1.8	2.0
Mood swings	3.4	6.2	11.2	2.1	1.9	2.2	2.8	3.4	2.4
Systolic blood pressure, automated reading	3.2	9.2	11.7	-2.9	-2.9	-2.6	-3.4	-3.0	-3.4
Medication: Atorvastatin	3.2	4.0	7.6	-1.4	-2.8	-1.8	-2.5	-1.3	-1.6
Bipolar Disorder (2011)	2.9	2.8	4.6	1.1	2.0	1.3	2.1	1.9	1.4
Eye problems/disorders: Diabetes related eye disease	2.9	3.1	5.8	-1.5	-2.4	-1.0	-2.3	-1.1	-1.7
Medication: Simvastatin	2.9	4.3	6.1	-1.8	-1.9	-1.5	-2.5	-2.3	-2.4
Average weekly red wine intake	2.9	4.2	7.3	-2.1	-1.1	-1.5	-2.5	-2.7	-2.0
Vascular/heart problems diagnosed by doctor	2.9	7.9	11.3	2.8	3.1	1.9	3.4	2.2	3.1
Happiness	2.8	3.4	5.1	1.5	1.4	2.2	1.9	2.2	1.6
Chronic bronchitis/emphysema (father)	2.7	3.2	4.2	1.7	2.0	1.7	1.4	1.9	1.9
Hair/balding pattern: Pattern 3	2.7	4.0	7.1	-1.4	-2.4	-1.5	-2.7	-2.1	-1.7
Sensitivity / hurt feelings	2.6	4.5	6.9	2.6	0.7	2.3	2.2	2.0	2.3
Pain all over the body in last month	2.6	2.8	4.3	1.1	1.6	1.8	2.1	2.0	1.2
Friendships satisfaction	2.6	3.2	4.0	-2.0	-1.9	-1.2	-2.0	-1.8	-1.7
HbA1C	2.5	2.8	6.7	-0.7	-1.6	-2.6	-1.5	-1.9	-1.1
High blood pressure (siblings)	2.3	3.3	3.9	-1.8	-1.7	-1.9	-2.0	-1.7	-1.9
Illnesses of siblings: Diabetes	2.3	2.8	4.1	-1.6	-2.0	-1.3	-1.7	-1.8	-1.5
High blood pressure	2.2	6.2	8.1	-2.8	-2.7	-1.8	-2.8	-1.7	-2.8
Financial difficulties in last 2 years	2.2	3.0	5.4	-2.3	-2.0	-1.0	-1.8	-1.4	-1.5
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	6.5	1.8	1.2	2.5	2.3	1.5	1.7
Reaction Time	2.1	4.1	5.8	2.1	1.7	2.4	1.6	2.2	2.1
Hypertension (Self-reported)	2.1	5.9	8.8	-3.0	-2.4	-2.0	-2.8	-1.6	-2.6
Neuroticism (2016)	1.9	2.7	4.8	1.1	1.4	1.2	2.2	1.9	1.9
Neck or shoulder pain in last month	1.9	2.7	5.4	-1.3	-1.7	-0.9	-1.4	-1.9	-2.3
Mineral and other dietary supplements	1.9	2.6	5.6	-2.4	-0.9	-1.3	-1.9	-1.2	-1.4
Hearing aid user	1.9	2.1	3.4	-1.6	-1.8	-0.4	-1.8	-1.5	-1.1
Mean time to correctly identify matches	1.8	3.5	5.8	2.4	1.1	2.3	1.3	1.9	1.9
Hair/balding pattern: Pattern 2	1.7	2.1	6.2	0.3	2.5	-0.2	2.0	1.1	1.0
Pulse wave reflection index	1.7	2.2	3.8	-1.7	-1.2	-0.8	-2.0	-1.4	-1.5
Knee pain experienced in last month	1.7	2.6	7.2	0.5	2.7	-0.8	1.8	1.3	1.6
Average weekly champagne plus white wine intake	1.7	2.4	3.6	-1.0	-1.7	-1.6	-1.5	-1.3	-1.9
Triglycerides	1.6	2.6	4.8	-1.9	-1.5	-1.6	-2.2	-1.2	-0.9
Worrier / anxious feelings	1.6	3.1	5.2	1.6	1.4	1.0	2.0	2.3	1.9
Breastfed as a baby	1.6	2.0	3.8	-0.7	-1.0	-2.0	-1.1	-1.6	-1.6
Miserableness	1.6	2.8	5.5	1.2	0.8	1.6	2.3	2.3	1.1
Medication: Lisinopril	1.6	2.1	3.7	1.9	1.6	0.6	1.9	1.2	0.8
Fractured/broken bones in last 5 years	1.6	2.0	4.1	0.3	2.0	1.5	1.7	1.4	0.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.4	-1.9	-1.5	-0.2	-1.1	-1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.2	-1.8	-0.7	-0.3	-1.6	-1.6	-1.3
Rheumatoid Arthritis	1.4	1.9	3.7	1.2	1.2	1.9	1.8	1.1	0.9
Prospective memory result	1.4	1.7	5.4	1.1	0.9	0.8	1.1	2.3	1.1
Exposure to tobacco smoke at home	1.4	1.6	3.0	-1.3	-1.7	-0.8	-1.2	-1.2	-1.2
Glaucoma (self-reported)	1.4	1.7	4.5	-1.3	-1.3	-0.0	-0.4	-1.5	-2.1
Medication: Amlodipine	1.4	1.9	3.2	-1.8	-0.9	-1.5	-1.5	-1.2	-1.3
Diastolic blood pressure, automated reading	1.4	4.2	6.2	-1.8	-2.0	-2.0	-2.5	-2.0	-1.9
Multivitamins +/- minerals	1.3	1.7	2.5	-1.5	-1.6	0.1	-1.4	-1.0	-1.6
Stomach or abdominal pain in last month	1.3	1.7	3.7	0.2	1.9	-0.0	1.6	1.7	1.0
Neuroticism score	1.3	2.8	5.9	1.1	0.1	2.0	1.5	2.4	1.9
Angina (self-reported)	1.3	1.7	3.2	-0.7	-1.8	0.1	-1.4	-1.4	-1.6
Depressed Affect (Nagel 2018)	1.2	2.4	6.8	1.2	0.5	1.4	1.4	2.6	1.5
Primary Biliary Cirrhosis	1.2	1.8	2.8	-1.3	-1.5	-0.4	-1.3	-1.7	-1.4
Health satisfaction	1.2	1.6	5.2	-2.3	-0.8	-0.7	-1.0	-0.5	-1.4
Family relationship satisfaction	1.2	1.5	4.1	-0.4	-2.0	0.1	-1.1	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.9	0.9	1.0	0.3	1.3	1.5	1.7
Guilty feelings	1.2	1.9	5.2	0.8	1.0	2.3	0.8	1.3	1.4
Age started oral contraceptive pill	1.2	1.5	2.4	1.0	1.6	0.6	1.4	1.4	1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.0	-0.4	-1.7	-1.4	-2.0	-1.4	-1.3
Average weekly spirits intake	1.1	1.4	2.7	1.3	1.6	-0.2	1.4	0.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.4	0.0	0.8	0.6	1.2	2.3	1.6
Falls in the last year	1.1	1.5	2.9	-0.5	-1.4	1.1	-1.7	-1.2	-1.0
Angina	1.0	1.3	2.7	-0.3	-1.7	0.4	-1.1	-1.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.6	1.4	0.5	0.5	1.0	1.2	1.6
Number of children fathered	1.0	1.2	2.7	-0.3	-0.5	-1.6	-0.9	-1.3	-1.2
Pulse wave peak to peak time	1.0	1.2	2.1	0.9	1.1	0.4	1.5	1.4	1.1
Shortness of breath walking on level ground	1.0	1.1	3.0	-1.3	-1.7	-0.9	-0.8	-0.2	-0.8
Neuroticism (Nagel 2018)	0.9	2.0	4.8	1.3	0.2	1.5	1.2	2.2	1.4
Worry (Nagel 2018)	0.9	1.8	4.1	1.1	0.3	1.2	1.3	2.0	1.6
Neuroticism	0.9	2.1	5.3	0.9	-0.0	1.2	1.2	2.3	1.9
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-0.8	-1.0	-0.1	-1.4	-1.3	-0.9
Birth weight of first child	0.9	1.7	3.4	0.4	0.9	0.8	1.4	1.7	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.6	-1.2	-0.8	-1.1	-1.2	-0.8	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.5	3.9	-2.0	-0.2	-1.9	-0.9	-0.9	-0.3
Medication: Ibuprofen	0.9	1.1	2.4	0.8	0.6	0.4	1.1	1.4	1.6
Alcohol intake frequency.	0.9	2.0	3.7	1.8	0.2	1.9	1.2	1.2	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	2.3	1.4	0.9	0.0	0.9	1.0	1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.9	1.4	1.0	1.0	1.3	0.5	1.0
Heart disease (siblings)	0.9	1.1	1.9	1.2	0.8	1.4	1.1	1.0	0.7
Prostate Cancer	0.8	1.1	2.1	-0.1	1.5	1.1	1.0	1.4	0.5
Heart attack	0.8	1.0	1.8	-0.3	-1.4	0.6	-1.0	-1.2	-1.0
Tense / ‘highly strung’	0.8	1.4	3.3	0.2	-0.5	1.6	0.9	1.8	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.6	-2.1	-0.7	-0.6	-0.7	-0.5	-1.1
Medication: Blood pressure	0.8	1.5	3.6	-1.4	-0.7	-1.9	-1.2	-0.3	-1.1
Suffer from ‘nerves’	0.8	1.3	3.2	0.3	-0.1	1.8	0.6	1.6	1.3
Ever had bowel cancer screening	0.8	1.0	2.1	-0.8	-1.4	-0.4	-1.4	-0.8	-0.7
Commuting to job workplace: Walk	0.8	0.9	2.1	0.1	-0.1	1.3	0.4	1.4	1.1
Ever depressed for a whole week	0.8	1.0	1.5	0.6	1.1	0.5	1.2	1.2	1.1
Unable to work because of sickness or disability	0.8	1.0	2.3	0.4	1.3	0.0	1.2	1.5	0.8
Bipolar Disorder (2018)	0.7	1.2	2.5	-0.4	1.6	0.8	1.4	0.8	1.0
Coronary Artery Disease (CAD)	0.7	0.9	2.4	-0.4	-1.5	0.3	-1.2	-1.0	-0.7
Mean Putamen Volume	0.7	0.8	1.9	0.8	0.5	-0.3	0.7	1.1	1.4
Chronotype (morning person)	0.7	1.6	3.7	-1.0	-1.9	-0.5	-1.2	-1.1	-1.4
Severe depression (siblings)	0.7	0.7	2.7	0.1	0.0	-0.6	-1.1	-1.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.7	1.1	-0.2	0.9	0.7	1.2	1.3
Depression (self-reported)	0.7	0.9	1.9	0.8	0.7	1.4	1.0	0.9	0.6
Lung cancer (father)	0.7	0.8	1.9	-0.6	-0.4	-0.9	-0.7	-1.2	-1.4
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	0.8	0.8	1.5	0.8	1.5	1.0
Medication: Aspirin	0.7	0.9	1.8	0.3	-1.4	-1.0	-1.3	-0.4	-1.0
Illnesses of father: Heart disease	0.7	1.0	2.8	-0.2	-1.7	-0.8	-1.2	-0.8	-0.5
Commuting to job workplace: Public transport	0.7	0.8	2.1	-0.9	-0.7	-0.6	-1.4	-0.8	-0.3
Medication: Blood pressure	0.7	1.4	2.4	-1.5	-1.6	-0.5	-1.4	-0.4	-1.1
Risk taking	0.7	1.0	3.1	-1.2	-0.2	-1.8	-0.4	-1.1	-0.5
Schizophrenia (2018)	0.6	1.2	2.9	-1.5	-1.2	0.4	-1.7	-0.5	-0.4
Alzheimer’s Disease (in father)	0.6	0.6	2.5	-1.6	-0.1	-0.6	-0.5	-0.3	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	-0.5	-0.8	-0.8	-1.2	-0.9	-0.9
Blood White Count	0.6	4.1	8.1	-1.8	2.4	-0.1	2.1	2.8	1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.7	-1.1	-0.2	-1.1	-0.3	-0.4	-1.3
Fed-up feelings	0.6	1.1	3.4	0.4	-0.6	1.8	0.6	1.3	0.5
Medication: Levothyroxine sodium	0.6	1.0	2.1	0.9	0.4	1.4	1.5	0.8	0.6
Mouth/teeth dental problems	0.6	0.9	3.0	0.2	-0.7	-0.8	-1.2	-1.7	-0.2
Alcohol intake versus 10 years previously	0.6	0.8	2.5	-1.3	-1.6	0.2	-0.7	-0.2	-0.5
Worry too long after embarrassment	0.6	1.0	3.7	-0.5	-1.9	-0.3	-0.9	-0.7	-0.6
Emphysema/chronic bronchitis	0.6	0.6	1.7	0.5	0.1	1.3	0.8	1.0	-0.5
Medication: Seretide 50 evohaler	0.6	0.7	1.2	0.9	0.4	0.9	1.1	0.6	0.7
Heart disease (mother)	0.6	0.7	2.5	-1.1	-0.4	-0.1	-0.1	-0.7	-1.6
Number of full sisters	0.6	0.7	2.4	-0.0	0.3	-1.1	0.2	0.6	1.6
Supplements: Vitamin C	0.6	0.7	2.8	1.7	-0.8	0.1	-0.6	-0.3	0.4
Smoking status: Previous	0.6	0.9	2.3	0.6	-0.6	-1.5	-0.5	-1.1	-1.0
Loneliness, isolation	0.6	0.8	1.9	-0.7	-1.4	0.5	-0.9	1.2	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.6	-0.2	1.1	0.3	1.0	1.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	-0.8	-1.1	1.0	-0.0	1.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	1.0	0.9	0.9	1.1	0.3	-0.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.3	-1.4	-1.5	-0.6	-1.4	-1.5	-0.6
Blood Platelet Count	0.5	6.2	11.5	1.8	3.4	0.6	3.2	2.5	2.3
Number of incorrect matches in round	0.5	0.9	3.6	1.9	0.2	0.8	0.2	1.0	-0.1
Past tobacco smoking	0.5	0.8	2.3	0.3	0.7	1.5	0.5	1.1	0.9
Nervous feelings	0.5	1.0	2.8	0.2	0.1	1.3	0.3	1.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.3	0.7	0.0	0.6	1.1	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	-1.6	-0.6	-1.0	-1.2	-0.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.7	0.4	0.3	0.4	1.3	0.7	0.8
Loud music exposure frequency	0.5	0.6	2.2	-1.5	-0.4	-0.8	-0.4	0.2	-0.4
Medication: Allopurinol	0.5	0.6	1.5	1.2	0.0	-1.1	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	-1.5	0.7	-1.3	-0.8	-0.0	0.9
Asthma (self-reported)	0.5	0.9	2.2	0.1	-0.8	1.4	-0.4	-0.6	-1.5
Medication: Aspirin	0.5	0.7	1.6	0.5	-1.3	-0.7	-1.1	-0.1	-0.8
Supplements: Calcium	0.5	0.6	1.1	-0.8	-0.9	-0.7	-0.6	-1.1	-0.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	1.1	-0.2	0.8	0.5	-0.1	0.6
Major Depression (MDD)	0.4	0.5	1.1	1.0	0.3	-0.1	0.5	0.8	0.8
Breast Cancer	0.4	1.0	3.1	0.2	-0.1	1.8	0.5	1.6	0.4
Hair Pigment	0.4	12.0	17.9	-2.5	-4.2	-2.1	-4.1	-3.7	-3.6
Vitamin and mineral supplements	0.4	0.5	1.0	0.4	0.7	-0.3	1.0	0.6	0.9
Supplements: Zinc	0.4	0.5	1.3	-0.4	-0.6	1.1	-0.8	-0.6	-0.4
Medication: Metformin	0.4	0.5	1.9	1.4	-0.1	0.7	-0.3	0.7	0.4
Pack years adult smoking proportion	0.4	0.6	1.6	-0.0	0.6	-0.5	0.8	1.3	0.9
Impedance of leg (right)	0.4	2.0	4.0	-0.2	-1.7	0.5	-1.6	-1.5	-2.0
Leg fat-free mass (left)	0.4	1.9	4.4	0.4	1.2	-0.0	1.3	1.9	2.1
Average weekly fortified wine intake	0.4	0.5	2.7	-0.4	0.0	1.6	0.2	0.2	-0.3
Taking other prescription medications	0.4	0.5	1.1	0.8	0.1	1.1	0.1	-0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	0.2	0.7	1.0	0.6	0.5	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-1.1	-0.6	-0.4	-0.3	0.1	-1.0
Supplements: Glucosamine	0.4	0.5	1.4	1.2	0.6	0.3	1.0	0.5	0.2
Impedance of leg (left)	0.4	2.1	3.9	-0.1	-1.7	0.3	-1.6	-1.6	-2.0
Waist circumference	0.4	1.4	2.6	0.6	1.2	0.2	1.3	1.6	1.6
Illnesses of siblings	0.4	0.6	1.3	0.9	0.7	1.1	0.6	0.3	0.5
Father’s age at death	0.4	0.6	2.0	0.5	0.7	-0.0	-0.2	1.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	-1.2	-1.2	0.6	-0.3	0.7	-0.3
Pulse rate	0.4	0.7	1.8	1.3	0.1	0.8	0.9	0.6	0.7
Asthma	0.4	0.8	1.8	0.2	-0.9	1.3	-0.3	-0.4	-1.3
Medication: Lansoprazole	0.4	0.5	1.4	-0.4	-0.4	0.6	-0.2	-0.8	-1.2
Illnesses of mother	0.4	0.5	1.3	0.4	0.5	0.4	-0.1	1.0	1.1
Arm fat mass (right)	0.4	1.6	3.0	0.6	1.2	-0.1	1.4	1.6	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.5	1.2	0.0	1.6	0.1	-0.1	0.4
Gout (self-reported)	0.4	0.5	1.9	0.7	-0.6	-1.4	0.1	-0.2	0.5
Number of full brothers	0.4	0.5	1.1	-0.5	-0.4	0.4	-0.5	-0.9	-1.0
Leg fat-free mass (right)	0.4	1.9	4.5	0.4	1.2	-0.0	1.4	1.9	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.4	0.8	1.0	0.4	0.1	-0.6
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.9	0.5	-0.2	-0.3	-0.5	-1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	0.3	1.4	0.1	0.9	0.0	0.4
Wears glasses or contact lenses	0.4	0.4	1.0	-1.0	-0.8	-0.5	-0.8	0.1	0.0
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	-0.6	-0.7	0.1	0.3	-0.8	-0.9
Medication: Bendroflumethiazide	0.4	0.6	1.4	-1.0	-0.6	-0.9	-1.2	0.0	-0.1
Irritability	0.4	0.7	1.5	1.0	-0.3	1.0	0.4	1.2	0.5
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.9	-0.9	0.3	-0.6	-0.4	-0.6
Pain experienced in last month	0.4	0.6	2.1	-0.6	-0.6	-1.4	-0.8	-0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.0	-0.2	-1.0	0.9	-0.7	-0.8	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.6	0.5	0.7	0.4	1.0	0.6
Crohns Disease (2017)	0.3	0.6	2.1	-0.5	-1.4	0.1	-1.0	-0.3	-0.4
HDL Cholesterol	0.3	0.4	1.4	-0.3	-1.2	0.4	-0.1	-0.4	-0.9
Schizophrenia (2014)	0.3	0.7	2.3	-0.8	0.3	1.5	0.1	0.9	0.4
Respiratory disease	0.3	0.6	2.7	-0.3	-0.4	0.7	-0.1	-0.3	-1.6
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.4	-0.5	1.1	0.2	0.8	0.3
Diabetes (mother)	0.3	0.3	0.9	0.4	-0.3	0.9	0.2	-0.8	-0.6
Townsend deprivation index at recruitment	0.3	0.5	0.8	-0.9	-0.8	0.5	-0.3	-0.4	-0.9
Maternal smoking around birth	0.3	0.5	0.9	-0.6	0.6	0.8	0.2	-0.7	-0.9
Relative age voice broke	0.3	0.4	0.9	-1.0	-0.3	0.6	-0.8	-0.1	-0.8
Age when periods started (menarche)	0.3	0.6	1.1	0.3	1.0	-0.2	0.9	0.9	1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.7	-0.7	0.9	-0.4	0.5	0.5	0.5
High blood pressure (mother)	0.3	0.4	0.7	-0.9	0.4	0.8	0.2	-0.2	-0.7
Body mass index (BMI)	0.3	1.1	2.1	0.4	1.1	-0.4	1.2	1.1	1.5
Leg predicted mass (left)	0.3	1.7	3.9	0.3	1.1	-0.1	1.2	1.8	2.0
Hearing difficulty/problems with background noise	0.3	0.5	2.6	-0.1	-1.6	0.1	-0.6	0.3	-0.0
Had other major operations	0.3	0.4	1.2	0.7	1.1	0.7	0.0	0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.0	0.1	0.5	0.6	0.4	1.0	1.0
Hip circumference	0.3	1.1	2.3	0.3	1.0	0.3	1.2	1.4	1.5
Number of live births	0.3	0.4	0.7	0.4	0.2	-0.4	0.9	0.9	0.7
Noisy workplace	0.3	0.4	0.9	0.2	0.3	-0.9	0.5	0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.2	0.6	-0.4	0.9	1.0	0.2
Medication: Paracetamol	0.3	0.5	1.3	0.3	-0.4	1.0	-0.3	-0.6	-1.1
Headache pain in last month	0.3	0.5	2.3	-0.4	-0.6	1.5	0.0	0.3	-0.2
Eye problems/disorders: None of the above	0.3	0.4	0.9	-0.9	-0.2	-0.6	-0.8	-0.2	-0.4
Pulse rate, automated reading	0.3	1.0	2.9	1.7	0.9	0.8	1.0	0.9	0.3
Comparative height size at age 10	0.3	1.6	3.7	0.9	0.2	1.9	0.9	1.6	1.4
Had major operations	0.3	0.4	0.9	-0.5	0.3	-0.8	0.0	-1.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	1.1	0.5	0.5	0.6	0.3	-0.3
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.5	-1.0	0.3	-0.9	-0.7	-0.8
Eye problems/disorders: Cataract	0.3	0.3	1.5	0.0	-0.1	-1.2	-0.3	0.2	0.6
Back pain experienced in last month	0.3	0.4	0.5	0.7	0.4	0.6	0.7	0.6	0.6
Breast cancer (self-reported)	0.3	0.3	0.6	0.6	0.6	0.3	0.8	0.5	0.6
Medication: Gliclazide	0.3	0.4	0.6	0.2	-0.8	0.1	-0.7	-0.7	-0.7
Leg predicted mass (right)	0.3	1.8	4.2	0.3	1.2	-0.0	1.4	1.8	2.1
Arm fat mass (left)	0.3	1.1	2.3	0.4	1.1	-0.4	1.2	1.2	1.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.9	0.4	0.3	1.4	0.4	0.6	-0.2
Financial situation satisfaction	0.3	0.3	0.8	-0.6	0.9	-0.7	0.5	0.2	-0.4
Illnesses of father: High blood pressure	0.3	0.4	1.9	-0.3	-0.4	0.4	0.3	1.4	0.2
Ever smoked	0.3	0.6	1.7	-1.2	-0.0	-1.3	-0.4	-0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.8	0.2	0.8	0.8	0.1	0.6
Pack years of smoking	0.3	0.4	1.1	0.0	0.6	-0.5	0.7	1.0	0.7
Arm predicted mass (left)	0.3	1.5	3.5	0.6	0.8	0.1	1.3	1.7	1.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.7	-1.3	0.0	0.8	-0.4	0.1	0.3
Depression (Nagel 2018)	0.2	0.3	1.0	0.0	-0.5	-0.2	-0.1	1.0	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	1.0	-0.0	0.7	0.3	-0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.3	-0.8	0.5	-0.6	-1.0	-0.3
Ovarian Cancer	0.2	0.3	0.6	0.7	0.5	0.5	0.4	-0.1	-0.6
Age at First Birth	0.2	0.2	0.9	0.8	0.1	0.9	0.0	-0.2	-0.0
Lupus	0.2	0.3	1.5	-0.3	-0.1	0.2	0.2	-0.6	-1.2
Blood Eosinophil Count	0.2	1.6	3.8	-0.6	1.1	1.5	0.9	1.9	1.1
Number of treatments/medications taken	0.2	0.3	0.9	-0.4	-0.3	-0.2	-0.8	-0.3	-0.9
Relative age of first facial hair	0.2	0.4	1.0	-0.6	-0.4	1.0	-0.6	-0.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.1	-0.8	0.8	0.2	0.2	0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.4	-0.3	0.4	-0.5	-0.3	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.2	-0.3	0.2	-0.1	-0.5	-0.8
Medication: Co-codamol	0.2	0.3	1.2	0.3	-0.5	-1.1	0.3	0.0	-0.2
Trunk fat percentage	0.2	0.9	1.1	1.0	0.9	0.3	1.0	1.0	1.0
Current tobacco smoking	0.2	0.3	0.7	-0.8	0.5	0.0	0.1	0.8	0.5
Trunk fat mass	0.2	0.9	1.8	0.8	0.9	0.1	1.0	1.1	1.4
Alcohol usually taken with meals	0.2	0.3	0.8	-0.5	0.1	0.9	-0.7	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.0	0.8	0.8	0.8	0.3	0.7
Diabetes (self-reported)	0.2	0.3	0.7	0.7	-0.8	-0.4	-0.4	0.2	-0.1
Weight	0.2	1.1	2.9	0.3	0.9	-0.1	1.0	1.3	1.7
Arm fat percentage (right)	0.2	0.9	1.5	0.5	1.1	-0.3	1.1	1.0	1.2
Length of working week for main job	0.2	0.2	0.3	0.6	0.0	0.5	-0.2	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	1.0	-0.4	0.4	0.7	0.2	0.1
Birth weight	0.2	0.5	1.2	1.1	0.3	0.3	1.0	-0.3	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.9	-0.4	-1.0	-0.0	-0.5	0.0	-0.5
Arm fat-free mass (right)	0.2	1.1	2.8	0.3	0.8	-0.2	1.0	1.4	1.7
Comparative body size at age 10	0.2	0.7	1.3	1.1	0.5	0.5	0.9	0.5	1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.2	0.7	0.3	0.9	0.4	0.0
Migraine (self-reported)	0.2	0.3	1.3	0.0	-0.3	1.2	-0.3	0.1	-0.5
Medication: Omeprazole	0.2	0.2	0.6	0.8	0.3	0.3	0.5	-0.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.3	-0.4	0.3	0.0	-0.7	-0.7
Whole body fat mass	0.2	0.7	1.5	0.6	0.7	-0.4	0.8	0.9	1.2
Overall health rating	0.2	0.4	1.6	-0.1	0.2	0.6	0.3	1.3	0.5
Chest pain or discomfort	0.2	0.4	0.9	0.2	-0.9	-0.9	-0.3	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	0.0	0.2	-1.0	0.2	-0.4	-0.4
Whole body fat-free mass	0.2	1.2	3.1	0.1	0.7	-0.2	0.9	1.5	1.8
Arm fat percentage (left)	0.2	0.8	1.4	0.4	1.2	-0.5	1.1	0.8	1.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.7	-0.7	-0.1	0.3	-0.2	-0.6
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.7	-0.9	-0.2	-0.9	-0.1	-0.5
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.5	-0.7	-0.0	-0.0	-0.4	-0.6
Smoking status: Current	0.2	0.4	1.8	-1.3	0.4	-0.3	-0.2	0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	-0.8	1.0	0.0	0.2	1.0	0.4
Whole body water mass	0.2	1.2	3.1	0.1	0.7	-0.3	1.0	1.5	1.8
Ever taken oral contraceptive pill	0.2	0.3	0.9	-0.5	-0.1	0.2	-0.5	-1.0	-0.3
Mother’s age at death	0.2	0.3	1.0	1.0	-0.2	-0.1	-0.2	-0.7	-0.5
Medication: Paracetamol	0.2	0.2	1.0	0.3	-0.1	1.0	0.4	0.3	-0.4
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	-0.4	0.1	-0.4	-0.6	-0.6
Basal metabolic rate	0.2	1.1	3.1	0.2	0.7	-0.2	0.9	1.4	1.8
Arm fat-free mass (left)	0.2	0.9	2.5	0.3	0.5	-0.2	0.9	1.3	1.6
Number of operations (self-reported)	0.2	0.3	0.6	0.5	0.8	-0.1	0.4	-0.7	-0.8
Average weekly beer plus cider intake	0.2	0.3	0.8	-0.1	0.9	-0.8	0.2	0.2	0.8
Myopia	0.2	0.2	0.7	-0.0	0.4	0.0	-0.4	0.5	0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.7	0.7	-0.2	0.7	0.4	-0.1
Alcohol drinker status: Previous	0.2	0.2	0.8	0.2	0.3	-0.6	-0.1	0.1	0.9
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	-0.5	-0.7	-0.2	-1.0	-0.0	-0.2
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.2	0.3	-0.1	-0.4	0.6	0.2
Crohns Disease (2012)	0.1	0.2	0.5	-0.7	-0.5	0.4	-0.3	-0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.4	-0.1	0.6	0.2	0.3	0.0
Ulcerative Colitis	0.1	0.2	0.5	-0.2	0.5	0.3	-0.0	0.6	0.7
Blood Red Count	0.1	1.1	4.9	-0.1	0.5	-0.3	0.2	1.1	2.2
Heel T-Score	0.1	0.6	1.8	-0.2	0.8	1.4	0.1	0.3	0.9
BMI	0.1	0.4	1.1	-0.4	0.6	-1.0	0.4	0.7	0.6
Height	0.1	2.0	5.8	0.9	-0.3	2.4	-0.3	1.7	1.5
Waist Hip Ratio (WHR)	0.1	0.3	1.4	0.3	-0.0	1.2	-0.1	0.5	-0.1
Smoking Status	0.1	0.2	0.8	-0.9	0.1	-0.5	0.1	0.5	0.2
Allergy or Eczema	0.1	0.2	0.5	0.4	0.5	0.1	-0.2	-0.2	-0.7
Hypothyroidism (self reported)	0.1	0.1	0.5	0.1	-0.7	0.3	0.1	-0.2	-0.3
Lung FEV1/FVC ratio	0.1	0.3	1.2	-0.4	-0.3	-1.1	-0.4	0.7	0.1
Tanning	0.1	0.7	1.8	1.3	0.9	0.4	1.1	-0.4	0.0
Hand grip strength (left)	0.1	0.4	0.8	0.8	-0.9	0.3	0.0	-0.0	0.9
Diabetes (father)	0.1	0.2	0.9	0.2	0.0	-0.1	0.9	0.3	-0.1
Hand grip strength (right)	0.1	0.3	0.7	0.8	-0.8	0.8	0.0	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.3	-0.4	0.4	-0.0	-0.6	0.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.3	0.4	0.2	-0.3	-0.2	-0.8
Medication: Atenolol	0.1	0.1	0.4	0.2	-0.4	0.5	-0.6	-0.2	-0.0
Had menopause	0.1	0.2	0.3	0.5	0.6	0.3	0.3	-0.2	0.3
Qualifications: None of the above	0.1	0.1	0.4	0.4	-0.1	0.5	0.2	0.6	-0.2
Allergy	0.1	0.3	0.8	-0.5	-0.1	-0.8	-0.4	-0.2	0.9
Medication: Ramipril	0.1	0.2	0.4	-0.1	-0.2	0.6	-0.3	-0.2	-0.7
Fluid intelligence score	0.1	0.1	0.4	0.3	-0.6	0.5	0.1	-0.3	0.2
Impedance of arm (right)	0.1	0.2	1.0	0.1	-0.1	1.0	-0.3	0.2	-0.6
Trunk fat-free mass	0.1	0.6	1.9	-0.1	0.2	-0.3	0.4	1.1	1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.8	-0.3	0.2	-0.9	-0.2	-0.2	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.2	-0.2	0.8	0.2	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.4	0.2	0.0	0.1	0.7	0.5
Impedance of arm (left)	0.1	0.3	1.3	0.1	0.3	1.2	-0.1	0.1	-0.4
Trunk predicted mass	0.1	0.6	1.9	-0.1	0.2	-0.3	0.5	1.1	1.4
Standing height	0.1	0.5	1.2	-0.0	-0.1	0.9	-0.1	1.0	1.1
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	1.0	-0.1	0.5	0.5	0.0	-0.0
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.0	-0.3	-0.7	0.3	-0.6	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	-0.1	0.5	0.1	0.3	0.4	0.6
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.1	0.6	0.4	0.6	0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	0.0	-0.0	0.7	-0.1	0.2	-0.2
Body fat percentage	0.1	0.3	0.6	0.8	0.6	-0.2	0.6	0.5	0.7
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.0	-0.0	0.3	-0.5	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.4	-0.5	0.6	-0.3	0.1	-0.3
Age at first live birth	0.1	0.1	0.4	0.3	0.1	-0.1	-0.2	-0.5	-0.6
Qualifications: College or University degree	0.1	0.2	0.8	0.1	-0.1	0.9	-0.5	-0.3	-0.1
Leg fat mass (right)	0.1	0.4	1.0	0.4	0.4	-0.5	0.5	0.6	1.0
Arm predicted mass (right)	0.1	0.6	1.8	0.1	0.4	-0.5	0.6	1.0	1.3
Age at last live birth	0.1	0.2	0.5	0.4	-0.1	0.6	0.2	0.7	-0.1
Leg pain on walking	0.1	0.1	0.2	0.0	0.0	-0.4	-0.1	-0.4	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.5	-0.1	0.4	-0.2	0.3	-0.1	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	-0.0	-0.2	0.6	0.0	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.5	0.2	-0.2	-0.2	-0.4	-0.6
Leg fat percentage (left)	0.1	0.3	0.6	0.8	0.7	-0.3	0.6	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.3	0.4	0.5	0.4	0.3	0.1
Impedance of whole body	0.1	0.7	1.7	0.0	-0.6	1.0	-0.8	-0.7	-1.3
Leg fat mass (left)	0.1	0.5	1.3	0.6	0.7	-0.3	0.8	0.7	1.1
Fasting Glucose	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.3	-0.1
Lung FVC	0.0	0.1	0.4	0.1	0.6	0.4	0.3	-0.2	-0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.0	0.0
Sitting height	0.0	0.3	1.0	-0.3	-1.0	-0.1	-0.7	-0.4	0.1
Forced vital capacity (FVC)	0.0	0.1	0.3	-0.5	0.3	-0.6	-0.2	-0.3	0.2
Forced vital capacity (FVC), Best measure	0.0	0.2	0.5	-0.5	-0.1	0.4	0.1	0.7	0.3
Leg fat percentage (right)	0.0	0.2	0.6	0.7	0.5	-0.3	0.4	0.1	0.2

Hub : Genes

RPS6

Models

Trait associations