Hub : Genes

RPS6KA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.082 0.0320 8.8e-03 0.020 0.004 -0.001 0.006 0.016 1.7e-03 8.4e-02 0.39000 0.061 4.1e-03
2 GTEx Adrenal Gland 0.334 0.0908 1.1e-03 0.099 NA 0.102 NA 0.110 2.1e-04 NA 0.00017 NA 9.4e-05
3 GTEx Brain Cerebellar Hemisphere 0.555 0.1410 3.9e-03 -0.002 NA 0.046 NA 0.007 3.7e-01 NA 0.02500 NA 2.1e-01
4 GTEx Esophagus Muscularis 0.231 0.0650 2.1e-03 0.072 NA 0.006 NA 0.040 3.7e-05 NA 0.14000 NA 1.7e-03
5 TCGA Kidney Renal Clear Cell Carcinoma 0.120 0.0341 2.6e-05 0.044 0.046 0.031 NA 0.046 8.8e-06 5.6e-06 0.00020 NA 5.5e-06
6 TCGA Testicular Germ Cell Tumors 0.304 0.0840 6.0e-04 0.038 0.114 0.012 NA 0.061 1.8e-02 7.8e-05 0.11000 NA 3.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 5.6 8.9 20.3 -0.2 4.5 -4.0 -2.7 2.8 -1.3
Bipolar Disorder or Schizophrenia 2.7 6.5 13.7 0.1 3.7 -3.5 -1.4 2.8 -1.8
Depressed Affect (Nagel 2018) 0.2 0.4 1.0 0.1 0.8 -1.0 0.2 -0.4 -0.7
Depression (Nagel 2018) 0.5 0.7 1.4 0.8 0.8 -1.2 -0.9 0.4 -0.7
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.8 0.4 -0.8 -1.0 1.1 -1.2 1.7
Neuroticism (Nagel 2018) 0.4 1.0 2.9 -1.1 1.1 -1.7 -0.5 0.5 -0.6
Schizophrenia (2018) 0.5 1.0 1.7 0.2 1.1 -1.3 0.3 1.3 -1.2
Schizophrenia vs Biploar Disorder 1.8 2.4 6.7 0.5 -2.1 2.6 1.1 -0.6 -1.0
Worry (Nagel 2018) 0.7 1.5 5.1 -0.8 0.8 -2.2 -0.1 1.1 -1.2
Alzheimer’s Disease (in mother) 0.6 0.7 3.0 -1.7 -0.9 0.2 -0.1 -0.3 0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.5 0.5 0.1 0.1 -0.1 -0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 4.5 -2.1 -0.7 0.3 0.1 -0.8 -0.3
Crohns Disease (2017) 2.0 4.4 7.6 -1.0 -2.8 -1.2 2.5 -2.5 -2.0
Irritable Bowel Disease (IBD) 2.6 6.1 12.1 -0.5 -2.2 -1.5 2.7 -3.5 -3.1
Ulcerative Colitis (UC) 1.5 2.8 7.2 0.2 -0.4 -0.9 1.4 -2.7 -2.6
Major Depression (MDD) 0.3 0.4 1.6 0.4 0.1 -0.5 1.3 -0.5 -0.2
Reaction Time 0.3 0.5 2.4 0.0 1.5 -0.8 0.1 -0.1 0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.5 0.1 -1.6 0.5 1.0 -1.5 1.1
Breast Cancer 0.9 2.2 5.8 0.0 -1.8 -0.1 1.2 -2.4 1.5
Ovarian Cancer 0.5 0.6 2.2 1.5 -0.9 -0.7 0.3 -0.3 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 1.1 2.5 -0.6 -1.5 -1.6 1.1 -0.1 -0.3
Bipolar Disorder (2011) 3.0 2.9 8.4 1.1 2.2 -2.9 -0.4 1.1 -1.2
Body Mass Index (BMI) (2010) 1.4 1.9 4.7 1.2 1.2 -1.1 -1.6 2.2 0.4
Coronary Artery Disease (CAD) 0.2 0.2 1.0 -0.3 -1.0 0.2 0.5 0.1 0.0
Crohns Disease (2012) 2.0 3.3 5.0 -1.0 -2.1 -2.0 2.0 -2.2 -1.1
Mean Putamen Volume 0.7 0.8 2.0 0.8 -1.2 -1.4 0.4 -0.1 0.9
Fasting Glucose 0.4 0.5 1.8 1.0 -1.3 -0.5 0.1 0.2 -0.3
HbA1C 1.0 1.2 3.2 1.8 0.8 -0.5 -0.2 0.8 -1.5
HDL Cholesterol 0.0 0.1 0.1 0.2 -0.1 0.3 0.4 0.4 0.3
LDL Cholesterol 0.4 0.6 2.3 -1.5 0.2 -0.4 0.2 -1.0 0.3
Lupus 0.8 1.3 2.9 -0.0 1.7 -1.2 -1.4 1.0 0.6
Neuroticism (2016) 0.9 1.3 4.4 1.3 -0.0 -2.1 0.5 0.4 -1.1
Primary Biliary Cirrhosis 1.4 1.9 5.9 -0.7 0.8 -0.7 -1.9 2.4 -0.8
Rheumatoid Arthritis 0.6 0.8 3.0 -1.7 0.6 0.7 0.5 -1.0 -0.4
Schizophrenia (2014) 0.9 2.1 4.0 0.3 1.5 -1.8 -0.5 1.7 -2.0
Triglycerides 0.7 1.1 4.0 -2.0 0.6 1.4 0.3 -0.0 0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 3.5 0.7 -1.9 -0.1 0.3 -0.0 0.1
Ulcerative Colitis 2.7 4.0 10.8 0.8 -1.0 -0.7 2.4 -3.3 -2.2
Blood Eosinophil Count 0.1 0.6 1.8 0.2 -0.1 -0.7 0.7 -1.3 -0.8
Blood Platelet Count 0.1 1.3 2.5 1.0 0.6 1.4 -0.5 -1.6 1.4
Blood Red Count 0.0 0.2 0.4 -0.5 0.1 -0.1 -0.5 -0.3 0.6
Blood White Count 0.1 0.4 2.1 0.0 0.1 -0.1 0.6 -1.5 -0.4
Heel T-Score 0.0 0.4 1.5 -0.4 0.0 1.2 -0.1 0.6 -0.5
BMI 0.9 5.1 9.0 -1.2 2.2 2.8 -2.7 3.0 0.3
Height 0.5 9.9 49.1 -7.0 -2.4 0.9 1.3 -0.3 -1.4
Waist Hip Ratio (WHR) 1.5 6.9 21.1 4.6 -1.4 -1.1 2.3 -3.0 -1.6
Systolic Blood Pressure 0.4 1.8 6.4 1.4 0.2 2.5 1.1 -1.1 -0.2
Smoking Status 0.3 0.6 2.3 -0.0 0.0 -1.1 -1.5 0.4 0.3
Allergy or Eczema 0.4 1.0 2.7 -0.1 0.9 -1.4 -0.4 -0.6 -1.6
Cardiovascular Disease 0.8 2.7 6.2 0.7 -2.2 0.9 1.1 -1.6 -2.5
Hypothyroidism (self reported) 0.4 0.9 1.6 0.8 -1.1 -1.0 0.9 -0.2 1.3
Respiratory disease 0.7 1.6 3.0 -1.7 -0.7 0.2 -1.5 1.6 -1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.5 -1.2 0.2 0.0 0.2 1.0 -0.7
Lung FEV1/FVC ratio 0.5 2.4 6.1 -0.1 0.1 1.2 -2.5 2.4 1.2
Lung FVC 1.0 5.0 17.9 4.2 -1.1 1.2 2.5 -1.7 -0.1
Neuroticism 0.7 1.6 4.8 -0.4 1.4 -1.5 0.0 0.6 -2.2
Chronotype (morning person) 0.2 0.6 1.9 -0.2 0.2 0.3 0.8 -0.9 1.4
Hair Pigment 0.1 1.8 3.0 0.5 1.7 -1.7 -0.8 1.6 -1.2
Tanning 0.1 0.8 2.9 1.7 0.6 -0.3 -0.9 0.6 0.4
Hand grip strength (left) 0.6 1.5 5.3 1.3 -0.1 2.3 -0.4 0.2 1.5
Number of treatments/medications taken 1.6 2.8 5.6 1.6 -1.9 0.6 2.4 -1.9 -1.1
Average weekly spirits intake 2.5 3.1 5.3 2.2 1.6 -0.2 -1.7 1.7 2.3
Sensitivity / hurt feelings 0.4 0.7 2.2 -0.2 0.9 -0.5 -0.6 1.5 0.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 4.3 1.5 0.2 -0.0 -0.1 -0.6 -2.1
Hearing difficulty/problems: Yes 0.6 0.9 2.0 -1.4 -1.2 -0.5 0.6 -0.2 -1.2
Relative age of first facial hair 1.5 3.2 6.4 -0.3 2.5 1.8 -1.9 2.0 1.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 2.8 0.0 -0.6 0.9 1.0 -1.7 -1.3
Ever used hormone-replacement therapy (HRT) 1.4 1.8 6.8 -0.7 0.7 2.6 -1.3 1.1 0.1
Ever had hysterectomy (womb removed) 0.5 0.5 1.0 -1.0 -0.0 -0.8 -0.2 -0.9 -0.7
Systolic blood pressure, automated reading 1.0 3.0 14.0 1.3 0.6 3.7 -0.0 -0.3 1.5
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.4 -1.7 0.2 0.8 1.6 -1.7 -1.9
Angina 1.4 1.8 3.6 -1.2 -1.1 1.0 1.9 -1.9 0.4
Medication for hormone replacement therapy 0.5 0.6 1.3 -0.9 0.8 1.1 -0.4 -0.5 -0.4
Vitamin and mineral supplements 1.3 1.7 3.6 -1.9 -0.1 0.5 -1.5 1.1 1.7
Supplements: Zinc 1.4 1.6 5.3 1.0 -0.5 0.9 1.3 -0.6 -2.3
Medication: Co-codamol 0.4 0.5 1.4 -0.7 0.6 -0.1 0.2 -0.7 -1.2
Medication: Metformin 0.2 0.3 1.8 -1.3 0.3 -0.1 0.0 0.1 0.2
Diabetes (father) 0.7 0.8 2.0 -1.4 0.5 -0.9 -0.5 0.4 1.2
Diabetes (mother) 0.1 0.2 0.7 0.0 -0.2 -0.5 -0.3 -0.1 -0.8
Severe depression (siblings) 1.3 1.5 3.3 0.0 -0.0 -1.8 -1.0 1.3 -1.7
Pack years adult smoking proportion 1.1 1.7 5.4 -2.3 1.6 -0.1 -0.6 0.9 1.2
Impedance of leg (right) 1.1 5.3 8.6 2.9 -2.9 -1.3 2.4 -2.5 -1.0
Leg fat-free mass (left) 1.0 5.5 19.7 -4.4 1.9 1.5 -2.0 1.7 -0.3
Trunk fat percentage 0.3 1.3 3.1 -1.3 0.1 1.8 -1.5 0.9 -0.1
Hand grip strength (right) 0.2 0.5 1.4 1.0 -0.1 1.2 0.0 0.1 0.9
Townsend deprivation index at recruitment 0.5 0.7 2.7 -1.0 0.5 0.7 -0.2 0.3 -1.6
Current tobacco smoking 0.3 0.6 1.3 0.8 -0.0 -0.8 -0.8 0.3 1.1
Average weekly fortified wine intake 0.2 0.2 0.9 0.2 -0.1 0.0 0.7 -0.9 -0.0
Maternal smoking around birth 0.5 0.7 2.6 -1.6 -0.5 0.7 0.2 0.7 -0.3
Fed-up feelings 0.6 1.0 4.9 -0.1 -0.3 -2.2 0.1 -0.4 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.1 -0.6 -0.4 -1.0 -0.2 -0.2 -1.4
Relative age voice broke 1.4 2.1 5.2 -0.3 1.1 -0.0 -2.3 1.8 1.7
Taking other prescription medications 0.4 0.7 1.3 0.7 -0.5 -0.5 1.2 -1.0 -0.9
Age when periods started (menarche) 0.9 2.1 3.8 1.7 -0.2 -1.9 -1.3 1.9 1.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.6 -0.6 0.2 -0.5 -0.7 -0.2 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 7.8 -0.3 0.1 2.8 1.6 -0.9 -1.4
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.4 -0.5 1.8 0.9 -1.2 1.1 -0.6
Qualifications: CSEs or equivalent 0.4 0.5 1.8 -0.8 -0.4 1.4 0.2 0.5 -0.0
Serious illness, injury or assault to yourself 0.5 0.6 1.8 1.0 1.3 0.0 0.3 -0.2 -0.8
High blood pressure 0.9 2.4 4.9 -0.2 -2.1 1.4 0.9 -1.5 -2.2
Hayfever, allergic rhinitis or eczema 0.8 1.7 5.0 -0.3 0.3 -2.2 -0.4 -0.6 -2.1
Multivitamins +/- minerals 0.9 1.2 3.0 1.7 1.1 0.1 1.2 -0.3 -1.0
Stomach or abdominal pain in last month 0.2 0.3 1.1 0.3 1.1 0.5 -0.2 0.1 -0.5
Supplements: Glucosamine 1.0 1.3 3.3 1.8 -0.7 -0.1 1.3 -0.7 -1.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.8 -0.2 -0.2 0.1 0.8 -1.7 0.7
Medication: Atenolol 2.2 2.8 3.6 1.9 -1.9 1.4 1.7 -1.8 1.2
Medication: Levothyroxine sodium 0.6 0.9 3.9 0.4 0.3 -0.4 -0.2 1.1 2.0
Sitting height 2.0 13.9 68.6 -8.3 -2.6 1.4 2.0 -0.6 -1.5
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 -0.3 -0.9 0.6 0.7 -0.3 0.5
High blood pressure (mother) 0.4 0.6 2.7 0.4 -0.7 -0.0 -0.2 -0.0 -1.6
Body mass index (BMI) 0.7 3.1 5.5 -1.4 1.7 2.1 -2.4 1.8 0.9
Impedance of leg (left) 1.2 5.7 10.2 2.8 -3.2 -0.8 2.5 -2.5 -1.5
Leg predicted mass (left) 1.1 5.7 20.3 -4.5 2.0 1.6 -2.1 1.7 -0.2
Trunk fat mass 0.5 2.1 4.2 -2.1 0.5 1.9 -1.7 1.2 -0.0
Waist circumference 0.3 0.9 2.9 -0.2 0.9 0.9 -1.7 0.9 0.5
Number of incorrect matches in round 1.5 2.5 8.1 0.8 2.8 1.0 -2.1 0.7 -0.4
Past tobacco smoking 0.4 0.7 1.7 0.2 1.3 0.9 0.2 1.1 0.2
Alcohol usually taken with meals 1.0 1.7 2.7 1.5 -1.3 -1.5 0.9 -0.6 1.6
Nervous feelings 0.3 0.5 1.6 0.6 0.5 -0.8 0.6 1.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.3 -1.2 0.6 -0.3 -1.5 0.9 -1.5
Hearing difficulty/problems with background noise 0.4 0.7 2.5 -1.0 -1.6 -0.6 -0.1 0.1 0.4
Hair/balding pattern: Pattern 2 1.0 1.3 7.4 -2.7 -0.5 0.1 -0.5 -0.0 0.1
Had menopause 1.0 1.3 3.9 1.8 -2.0 0.7 0.3 -0.1 0.1
Had other major operations 0.4 0.5 1.7 0.9 -0.1 0.1 -0.5 -0.1 -1.3
Forced vital capacity (FVC) 0.4 1.6 3.3 0.2 -1.1 -0.5 1.6 -1.5 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 6.2 -0.3 0.6 2.5 1.3 -0.8 -0.5
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 4.8 -0.3 0.1 1.7 0.7 0.3 -2.2
Qualifications: None of the above 1.0 2.1 4.3 -1.3 -1.2 0.5 1.3 -2.1 -1.8
Financial difficulties in last 2 years 1.5 2.0 6.9 0.4 1.4 -1.5 0.1 -0.8 -2.6
Mouth/teeth dental problems 0.9 1.3 4.1 0.6 -0.8 0.7 2.0 -1.5 -0.3
Heart attack 0.6 0.7 2.8 0.4 -1.7 -0.5 0.5 -0.3 0.9
Allergy 0.5 1.2 4.5 0.9 -0.5 0.9 1.0 -0.1 2.1
Pain all over the body in last month 1.8 1.9 4.4 1.6 1.3 2.1 -1.2 0.3 1.1
Diabetes (self-reported) 0.8 1.2 4.8 -2.2 0.1 -1.0 0.9 -0.4 -0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 -0.1 0.6 0.8 -0.3 0.9 -0.9
Medication: Ramipril 0.5 0.6 2.2 -0.1 0.7 1.5 0.1 -0.0 1.1
Medication: Simvastatin 0.1 0.2 0.5 0.1 -0.5 -0.2 0.7 -0.4 -0.0
Fluid intelligence score 0.7 1.6 3.9 -0.6 -2.0 -0.6 1.5 -1.1 1.2
Illnesses of siblings 0.5 0.7 2.7 -0.5 1.6 0.3 -0.7 0.5 0.8
Neuroticism score 0.3 0.5 1.8 0.0 0.6 -0.9 0.4 0.1 -1.3
Weight 0.7 3.5 10.5 -3.2 1.2 2.0 -1.8 1.4 -0.0
Impedance of arm (right) 0.2 0.8 1.1 1.0 -0.9 -1.0 0.7 -0.8 -0.8
Arm fat percentage (right) 0.7 2.9 6.5 -0.9 1.8 1.7 -2.5 1.9 0.7
Trunk fat-free mass 0.6 3.7 17.2 -4.2 1.1 1.3 -1.2 0.8 -0.3
Hip circumference 1.4 5.8 14.7 -3.8 1.7 1.5 -2.7 2.5 1.1
Time employed in main current job 0.2 0.3 0.4 -0.2 0.6 -0.6 -0.0 -0.7 0.6
Alcohol intake versus 10 years previously 0.8 1.1 3.0 -1.5 -0.3 0.8 -0.0 -0.8 -1.7
Father’s age at death 0.5 0.7 2.0 1.4 0.3 -0.6 -1.0 0.7 0.4
Worrier / anxious feelings 0.3 0.5 1.3 -0.6 1.1 -1.0 -0.5 0.1 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 5.1 -1.4 -0.6 0.6 1.8 -1.0 -2.3
Falls in the last year 0.5 0.7 2.0 -1.0 0.5 -0.3 -1.4 1.1 -0.2
Hair/balding pattern: Pattern 3 0.7 1.0 2.8 1.7 0.1 -0.1 1.4 -0.8 -0.8
Number of live births 0.4 0.5 2.0 1.4 0.6 -0.5 -0.1 0.3 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.6 0.4 -1.0 0.2 1.3 -0.5 -0.9
Pulse rate 0.4 0.7 2.1 -1.5 0.8 0.8 -0.6 -0.0 -0.6
Happiness 0.3 0.4 1.5 -0.6 0.2 0.4 -0.0 -1.2 0.3
Noisy workplace 1.7 2.1 5.7 -2.2 0.2 0.9 0.8 -0.8 -2.4
Qualifications: A levels/AS levels or equivalent 0.7 1.6 5.5 0.4 -1.6 -2.3 1.1 -0.7 -0.0
Serious illness, injury or assault of a close relative in last 2 years 3.2 3.6 7.3 -1.6 -1.7 0.7 2.3 -1.8 -2.7
Mouth/teeth dental problems: Dentures 0.5 0.9 4.4 -2.1 -0.3 -0.2 -0.8 0.2 0.4
Asthma 0.2 0.4 1.0 -1.0 -0.8 0.8 -0.5 0.3 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.5 -1.2 -0.1 -1.5 0.5 -0.4 -1.6
Medication: Cholesterol lowering 1.5 2.3 5.1 1.0 -1.7 -0.8 1.9 -2.3 -0.8
Depression (self-reported) 0.8 0.9 3.2 0.1 1.0 -1.0 -0.4 -0.2 -1.8
Medication: Lansoprazole 1.9 2.2 6.1 -1.4 -1.7 2.5 -0.6 -0.1 -1.3
Prospective memory result 0.8 0.9 2.3 1.0 -0.5 0.3 1.4 -1.5 -0.2
Lung cancer (father) 2.1 2.4 7.0 -0.1 -1.8 -0.7 1.7 -2.6 0.8
Illnesses of mother 0.6 0.8 2.7 0.3 1.6 -1.1 -0.2 0.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 -0.2 0.2 0.4 0.3 0.5 -0.4
Pulse wave Arterial Stiffness index 1.0 1.1 3.1 -1.8 -1.6 -0.8 -0.5 -0.2 -0.7
Impedance of arm (left) 0.4 1.7 2.8 1.7 -1.2 -1.2 1.2 -1.1 -1.5
Arm fat mass (right) 0.9 3.6 6.2 -1.9 1.8 2.1 -2.5 2.0 0.7
Trunk predicted mass 0.6 3.6 16.8 -4.1 1.1 1.3 -1.2 0.8 -0.3
Standing height 0.5 4.7 21.3 -4.6 -1.1 0.1 1.0 -0.6 -2.1
Length of working week for main job 1.0 1.1 3.4 -0.5 0.8 -0.4 -1.0 1.1 1.8
Exposure to tobacco smoke at home 0.4 0.5 1.2 1.1 -0.7 -0.0 0.1 -0.0 -1.1
Breastfed as a baby 1.1 1.3 4.7 -1.7 2.2 0.4 0.1 -0.3 -0.1
Tense / ‘highly strung’ 0.3 0.5 0.9 0.3 -0.5 -0.9 -0.7 0.9 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 9.3 0.4 -0.5 -1.2 1.4 -0.7 -3.1
Hair/balding pattern: Pattern 4 0.8 1.9 4.6 -2.1 -1.2 0.3 1.4 -1.7 -0.6
Birth weight of first child 0.3 0.5 1.3 0.6 1.1 -0.4 0.3 -0.5 -1.0
Peak expiratory flow (PEF) 0.2 0.4 1.1 -0.0 -0.9 0.6 1.0 -0.4 -0.5
Pulse wave reflection index 1.3 1.6 6.2 -0.7 -2.5 -0.5 1.1 -1.1 -0.1
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.4 -0.2 0.4 -0.0 1.0 -1.3 -2.1
Loud music exposure frequency 0.7 0.7 2.1 0.8 0.3 -0.4 -1.4 1.1 0.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.1 1.2 0.3 -1.8 0.0 -0.5 -1.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.1 1.7 1.5 -0.2 -1.1 1.8 1.1
Blood clot in the leg (DVT) 1.4 1.8 4.9 -1.0 2.2 -0.2 -2.1 0.5 -0.1
Medication: Paracetamol 0.5 0.8 1.2 -1.0 1.1 -0.5 -1.1 1.0 -0.3
Headache pain in last month 0.4 0.7 1.6 -0.0 1.2 -1.2 -0.6 0.7 -0.3
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 4.0 -0.2 1.7 0.7 -2.0 2.0 0.5
Glaucoma (self-reported) 0.3 0.4 0.6 0.7 0.5 -0.7 0.0 -0.8 -0.6
Gout (self-reported) 1.6 2.2 5.1 -1.3 -1.4 -0.9 2.3 -1.8 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.8 0.5 -1.4 -0.2 1.2 -0.4 1.3
Medication: Amlodipine 0.3 0.4 1.6 -0.0 0.2 0.7 -0.5 0.0 -1.2
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.8 -0.1 -0.9 0.7 0.3 -0.5 -0.6
Birth weight 0.3 0.8 1.6 0.7 1.1 1.0 0.0 -0.5 -1.3
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.1 0.1 -0.5 0.8 -0.7 -0.6
High blood pressure (siblings) 0.4 0.6 1.5 1.2 -1.2 0.3 -0.6 0.1 0.6
Forced vital capacity (FVC), Best measure 0.2 0.7 2.9 -0.1 -0.3 -0.3 1.1 -0.4 -1.7
Body fat percentage 0.3 1.3 3.7 -0.7 0.3 1.9 -1.6 0.9 0.2
Leg fat percentage (right) 0.5 1.8 4.4 0.8 0.9 1.6 -2.1 0.9 1.2
Arm fat-free mass (right) 0.7 3.4 15.2 -3.9 0.7 1.5 -1.0 1.0 -0.5
Exposure to tobacco smoke outside home 1.3 1.8 8.0 -2.8 1.3 -0.6 -0.1 0.6 -0.7
Comparative body size at age 10 0.6 1.7 6.7 -0.4 0.9 0.1 -2.6 1.5 -0.2
Number of full brothers 0.9 1.2 3.6 -0.5 -0.7 0.3 1.5 -0.7 -1.9
Worry too long after embarrassment 0.4 0.7 2.5 -0.5 -1.6 -0.5 1.1 -0.1 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.2 -0.4 1.3 -1.4 -0.0 0.6 -2.3
Wheeze or whistling in the chest in last year 0.6 1.0 3.9 -2.0 0.5 -0.1 -0.8 0.6 0.8
Number of children fathered 1.2 1.3 3.6 -0.2 0.6 1.1 -1.9 1.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 -0.0 -0.7 0.7 0.1 0.3 1.3
Age at first live birth 0.5 0.9 3.4 -0.8 0.9 0.7 -0.0 0.4 1.8
Pulse wave peak to peak time 0.7 0.8 2.1 1.3 1.4 0.8 0.5 0.1 0.6
Health satisfaction 0.6 0.7 1.6 0.3 1.0 0.6 0.8 -1.3 -0.8
Shortness of breath walking on level ground 1.4 1.7 4.2 -1.4 2.1 0.3 -1.1 1.3 0.8
Qualifications: College or University degree 0.4 1.3 2.8 1.7 -0.9 -1.0 1.4 -1.0 0.2
Eye problems/disorders: None of the above 1.0 1.1 3.6 -1.5 0.3 1.9 -0.7 -0.0 0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 0.1 1.4 -1.0 -0.3 -0.1 -0.5
Emphysema/chronic bronchitis 0.7 0.8 2.7 -0.3 -1.2 1.6 0.2 -0.5 0.0
Medication for pain relief, constipation, heartburn 0.5 0.8 1.5 1.2 -0.6 1.0 -0.5 0.4 1.2
Neck or shoulder pain in last month 2.1 3.0 7.0 -1.1 -0.1 -0.3 2.1 -2.3 -2.6
Medication: Blood pressure 0.9 1.6 3.2 0.7 -1.3 -1.0 1.8 -1.8 0.2
Angina (self-reported) 1.4 1.9 4.3 -1.0 -1.1 0.6 2.0 -2.1 0.2
Migraine (self-reported) 1.0 1.2 5.1 2.3 -0.7 -0.8 0.7 -0.7 -0.1
Medication: Ibuprofen 0.4 0.4 0.7 -0.8 0.5 -0.8 -0.7 0.6 -0.5
Medication: Allopurinol 1.6 2.1 4.6 -0.8 -1.6 -1.5 2.1 -1.7 0.3
Medication: Omeprazole 0.3 0.4 1.2 -1.1 -0.1 0.1 0.9 -0.6 0.4
Medication: Seretide 50 evohaler 0.9 1.1 1.8 -1.3 -0.3 0.9 -1.2 1.3 0.8
Mean time to correctly identify matches 0.1 0.2 1.1 -0.4 1.1 -0.1 -0.4 0.2 -0.0
Heart disease (mother) 0.5 0.6 1.2 1.0 -0.2 0.6 0.7 -0.8 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.2 8.2 1.9 0.2 2.9 -0.2 -0.5 0.9
Whole body fat mass 0.5 1.9 3.4 -1.9 0.7 1.8 -1.7 1.2 0.1
Leg fat mass (right) 0.6 2.2 4.8 -1.0 1.3 1.8 -2.2 1.4 0.6
Arm predicted mass (right) 0.6 3.1 12.6 -3.5 0.9 1.5 -1.2 1.2 -0.4
Pulse rate, automated reading 0.1 0.3 1.3 -0.2 -0.1 -0.1 -0.6 -0.1 -1.1
Alcohol intake frequency. 1.1 2.5 11.3 -1.5 0.2 0.5 0.7 -0.8 -3.4
Comparative height size at age 10 0.4 2.1 6.0 -2.5 -1.3 -0.5 0.7 -1.2 -1.7
Number of full sisters 0.1 0.2 0.5 -0.3 0.2 0.2 -0.6 0.7 0.1
Suffer from ‘nerves’ 0.9 1.3 5.2 -2.3 -0.6 -0.3 1.1 -0.4 -1.1
Overall health rating 0.1 0.3 1.0 0.0 -0.3 0.3 0.4 -1.0 -0.5
Chest pain or discomfort 0.4 0.6 2.6 -1.6 0.2 0.8 -0.2 -0.3 -0.7
Had major operations 1.4 1.7 4.8 -0.1 -2.2 -0.9 1.1 -1.6 -0.6
Age at last live birth 0.7 1.0 2.4 -0.8 1.6 0.7 -1.1 0.5 0.9
Family relationship satisfaction 0.5 0.7 2.4 0.6 -0.1 1.6 -0.2 -0.4 1.0
Leg pain on walking 1.8 2.2 7.2 -0.2 2.0 2.7 -1.3 0.0 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.9 -0.8 -0.0 -0.5 -1.0 -0.0 -0.9
Commuting to job workplace: Car/motor vehicle 2.9 3.3 5.2 -1.2 -2.2 -1.0 2.1 -2.3 -1.6
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 9.2 -0.2 1.0 0.1 -1.2 1.6 3.0
Medication: Aspirin 0.3 0.3 0.9 1.0 -0.0 -0.3 0.4 -0.5 0.8
Supplements: Vitamin C 0.8 1.0 3.4 -0.3 -0.6 -0.7 0.6 -1.1 -1.8
Knee pain experienced in last month 1.2 1.9 5.5 -2.2 2.3 0.7 -0.5 0.4 -0.3
Hypertension (Self-reported) 0.7 1.9 4.7 0.2 -1.8 1.4 0.6 -1.1 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.3 -0.8 -1.6 1.8 0.4 -0.6 -0.5
Illnesses of father: Heart disease 0.8 1.1 5.7 -0.5 -0.3 0.6 -0.2 0.3 -2.4
Illnesses of siblings: Diabetes 0.4 0.5 1.2 1.1 -0.5 -0.5 0.1 -0.6 -1.1
Smoking status: Previous 0.5 0.7 1.1 -0.6 -1.1 -0.7 0.3 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 6.2 -2.5 -0.2 0.2 0.6 -0.5 -1.6
Whole body fat-free mass 0.8 4.7 20.1 -4.5 1.4 1.5 -1.5 1.2 -0.3
Leg fat-free mass (right) 1.2 6.2 22.8 -4.8 1.9 1.6 -2.1 1.9 -0.4
Arm fat percentage (left) 0.7 2.7 6.2 -0.7 1.9 1.6 -2.5 1.8 0.3
Average weekly red wine intake 0.8 1.2 6.2 2.5 -0.4 0.3 -0.6 0.2 0.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 4.6 -0.3 2.2 0.1 -1.0 0.9 0.2
Mood swings 0.8 1.4 5.6 -0.9 0.0 0.1 1.0 -0.9 -2.4
Loneliness, isolation 1.4 1.9 5.0 -0.9 -0.7 -1.5 1.4 -0.8 -2.2
Long-standing illness, disability or infirmity 1.2 1.8 5.6 0.5 -1.2 -0.2 1.3 -1.4 -2.4
Ever had bowel cancer screening 0.2 0.2 0.5 -0.2 -0.3 0.7 0.7 -0.3 -0.2
Diabetes diagnosed by doctor 0.4 0.6 2.9 -1.7 0.3 -0.6 0.5 -0.1 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 2.6 1.6 0.9 0.3 -1.2 0.8 -1.1
Friendships satisfaction 0.2 0.3 0.6 -0.2 0.5 0.4 0.4 -0.5 0.8
Qualifications: nursing, teaching 0.3 0.4 1.7 1.3 0.6 0.4 -0.7 -0.0 0.0
Commuting to job workplace: Walk 0.7 0.7 2.7 1.7 0.1 -1.3 0.2 -0.1 -0.1
Eye problems/disorders: Cataract 0.4 0.5 1.7 0.8 -0.3 -1.3 0.4 0.1 0.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 2.7 1.1 1.3 0.7 -1.6 1.2 0.3
Medication for cholesterol 0.5 0.8 1.9 1.1 0.5 -1.4 -0.3 0.3 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 4.1 -0.1 -0.0 0.4 1.0 -1.1 2.0
Back pain experienced in last month 0.9 1.4 5.2 -0.3 0.0 -0.8 1.4 -0.6 -2.3
Mineral and other dietary supplements 1.2 1.7 6.2 -2.5 -1.1 1.5 0.1 -0.3 -0.2
Breast cancer (self-reported) 0.8 1.0 3.9 -1.0 -0.7 0.3 0.2 -0.4 2.0
Asthma (self-reported) 0.3 0.5 1.2 -1.1 -0.8 1.0 -0.5 0.3 0.2
Osteoporosis (self-reported) 0.4 0.5 1.7 -0.1 0.4 -1.3 -0.6 -0.1 0.9
Osteoarthritis (self-reported) 0.2 0.3 0.7 -0.7 0.7 0.3 -0.1 0.1 0.9
Medication: Aspirin 0.2 0.3 0.6 0.7 0.4 -0.8 0.1 -0.3 0.7
Medication: Gliclazide 0.8 0.9 3.4 -0.8 -0.1 -0.9 0.5 -0.6 -1.8
Illnesses of father: None of the above (group 1) 0.5 0.7 3.2 0.1 0.1 -0.6 -0.2 -0.5 1.8
Smoking status: Current 0.4 0.6 1.7 1.0 -0.1 -0.7 -0.7 0.1 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 5.5 2.3 0.0 0.7 0.3 -0.0 0.3
Whole body water mass 0.8 4.8 19.8 -4.5 1.4 1.5 -1.6 1.4 -0.3
Leg predicted mass (right) 1.1 6.1 22.4 -4.7 1.9 1.6 -2.1 2.0 -0.4
Arm fat mass (left) 0.8 3.4 5.8 -2.0 1.8 1.9 -2.4 2.0 0.4
Number of self-reported non-cancer illnesses 0.8 1.4 3.3 0.5 -1.3 -0.2 1.1 -1.5 -1.8
Average weekly champagne plus white wine intake 1.6 2.2 8.9 -1.9 -0.2 0.9 -0.2 0.1 3.0
Miserableness 0.2 0.3 1.0 -0.1 1.0 -0.5 -0.4 0.3 -0.6
Guilty feelings 0.4 0.6 2.0 0.8 -1.0 -0.2 0.1 -1.4 -0.1
Wears glasses or contact lenses 1.7 2.0 4.2 0.4 -2.0 -0.3 2.0 -1.8 0.2
Ever taken oral contraceptive pill 0.3 0.3 1.1 0.7 0.2 -0.3 0.2 -1.0 -0.1
Hearing aid user 0.3 0.4 0.9 0.9 -0.6 0.8 0.3 0.1 0.5
Mother’s age at death 0.7 0.8 3.1 -0.3 -1.8 -1.0 0.2 -0.8 0.2
Financial situation satisfaction 0.5 0.6 2.7 0.1 1.6 -0.2 -0.4 -0.8 -0.1
Tinnitus: Yes, now most or all of the time 0.8 1.0 3.2 -0.5 -0.5 1.8 0.4 -0.3 -1.4
Commuting to job workplace: Public transport 2.2 2.6 4.7 0.2 2.2 -1.1 -1.3 2.1 1.8
Eye problems/disorders: Glaucoma 0.3 0.3 1.3 0.4 1.1 0.3 -0.6 -0.2 0.2
Medication: Blood pressure 1.0 2.0 3.6 -0.5 -1.7 1.5 1.2 -1.3 -1.9
Pain type(s) experienced in last month: Hip pain 1.7 2.1 4.3 -0.2 -1.9 0.6 1.7 -2.1 -1.4
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.2 2.0 1.0 -1.6 0.2 0.6 -0.3
High cholesterol (Self-reported) 0.2 0.3 1.3 0.1 -0.6 1.1 -0.2 0.3 0.5
Medication: Bendroflumethiazide 0.5 0.8 1.9 -0.9 -0.1 0.2 -1.4 1.2 0.8
Medication: Paracetamol 0.1 0.2 0.5 -0.4 0.4 -0.3 -0.2 0.3 -0.7
Medication: Lisinopril 1.3 1.7 5.5 1.3 -0.9 -0.7 1.0 -2.4 -0.7
Medication: Atorvastatin 0.7 0.9 1.7 0.4 -1.0 1.3 -0.6 1.0 1.0
Illnesses of father: High blood pressure 2.0 2.5 5.5 0.8 1.8 -0.1 -2.2 2.3 -0.8
Alcohol drinker status: Never 1.3 1.6 3.9 -1.5 1.3 0.7 0.8 0.5 -2.0
Ever smoked 0.4 0.7 1.1 0.7 -0.6 -1.1 -0.5 -1.1 0.9
Basal metabolic rate 0.9 4.9 19.0 -4.4 1.5 1.7 -1.7 1.4 -0.3
Leg fat percentage (left) 0.5 1.8 4.6 0.5 0.8 1.8 -2.1 1.0 0.9
Arm fat-free mass (left) 0.7 3.7 16.6 -4.1 0.7 1.8 -1.0 0.9 -0.0
Number of operations (self-reported) 0.2 0.2 1.0 -0.1 -0.3 -0.5 -0.3 -1.0 -0.2
Average weekly beer plus cider intake 1.3 1.9 6.8 -0.2 1.0 0.7 -1.3 1.1 -2.6
Irritability 0.6 1.0 3.9 -2.0 1.3 -0.6 -0.5 -0.0 -0.1
Risk taking 0.9 1.3 2.4 -1.3 1.1 -0.7 -1.5 1.3 0.5
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.0 1.3 1.7 -1.2 0.5 -0.5 -1.1
Fractured/broken bones in last 5 years 0.5 0.6 3.2 0.2 1.8 -0.3 -0.6 0.1 0.3
Age started oral contraceptive pill 0.7 0.9 2.8 1.7 -0.5 1.0 -0.7 0.7 0.8
Diastolic blood pressure, automated reading 1.0 3.2 7.3 -2.7 1.8 2.2 -1.1 1.0 1.1
Ever depressed for a whole week 0.8 0.9 4.5 -0.3 0.1 0.8 0.6 0.3 -2.1
Unable to work because of sickness or disability 0.3 0.4 1.0 1.0 0.8 -0.1 -0.4 0.3 -0.7
Commuting to job workplace: Cycle 0.4 0.5 1.0 -0.8 0.4 -1.0 -0.4 -0.8 0.6
Myopia 0.3 0.5 0.8 0.5 -0.9 0.2 0.9 -0.9 0.3
Vascular/heart problems diagnosed by doctor 1.3 3.5 7.5 0.3 2.7 -1.1 -1.9 2.0 2.2
Cholesterol lowering medication 0.7 1.0 2.6 0.2 -0.2 1.5 -0.6 1.6 0.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.4 -0.7 0.0 0.8 1.2 -1.1 -0.6
Pain experienced in last month 0.5 0.8 1.8 -0.5 -1.0 -0.5 -0.9 0.7 1.4
Supplements: Calcium 0.5 0.6 2.1 0.8 0.3 -1.5 -0.7 0.1 0.2
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 0.1 -0.1 -0.3 0.8 -0.4 -1.1
Heart attack/myocardial infarction (self-reported) 0.4 0.6 2.4 0.2 -1.6 -0.1 0.5 -0.3 0.7
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 4.1 -1.2 2.0 -0.0 -2.0 0.7 -0.2
Heart disease (siblings) 0.8 1.0 1.7 0.0 -1.2 -1.3 1.2 -1.0 -0.6
Alcohol drinker status: Previous 0.3 0.3 1.0 0.1 0.5 -0.4 -0.6 1.0 -0.6
Pack years of smoking 1.2 1.8 6.1 -2.5 1.6 0.3 -0.5 0.6 1.2
Impedance of whole body 0.7 3.7 5.9 1.7 -2.4 -1.1 2.3 -2.2 -1.6
Leg fat mass (left) 0.5 2.1 4.6 -1.1 1.2 1.9 -2.1 1.3 0.5
Arm predicted mass (left) 0.9 4.3 18.3 -4.3 1.0 1.7 -1.4 1.4 0.1