TWAS hub - RPS6KA4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.085	0.0420	0.0032	0.078	NA	0.058	NA	0.058	1.1e-07	NA	4.6e-06	NA	4.8e-06
2	YFS	Blood	0.309	0.0438	0.0000	0.278	0.26	0.281	0.014	0.048	1.7e-91	1.1e-84	9.2e-93	1.9e-05	2.2e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Gout (self-reported)	7.8	10.8	13.1	-2.9	-3.6
Hearing difficulty/problems: Yes	7.7	11.7	11.7	-3.4	-3.4
Hearing difficulty/problems with background noise	6.4	10.2	10.2	-3.2	-3.2
Had other major operations	6.0	7.4	9.0	3.0	2.4
Illnesses of father: None of the above (group 1)	6.0	7.4	8.5	2.9	2.5
Allergy or Eczema	5.4	14.3	15.1	-3.7	-3.9
HbA1C	4.9	5.4	5.7	-2.4	-2.3
Average weekly spirits intake	4.7	5.9	5.9	2.4	2.4
Body Mass Index (BMI) (2010)	4.6	6.3	6.8	2.6	2.4
Medication: Allopurinol	4.6	6.1	7.8	-2.1	-2.8
Sensitivity / hurt feelings	4.4	7.6	7.9	2.7	2.8
Shortness of breath walking on level ground	4.4	5.2	5.2	-2.3	-2.3
Medication: Atenolol	4.3	5.4	5.6	-2.3	-2.4
Had menopause	4.2	5.3	5.6	-2.2	-2.4
Commuting to job workplace: Walk	4.0	4.3	5.1	-1.9	-2.3
Medication: Lansoprazole	3.8	4.3	5.0	-2.2	-1.9
Noisy workplace	3.7	4.6	5.4	-1.9	-2.3
Blood Red Count	3.5	33.9	34.1	-5.8	-5.8
Financial situation satisfaction	3.5	4.4	4.9	-2.0	-2.2
Qualifications: A levels/AS levels or equivalent	3.4	7.4	8.3	2.6	2.9
Hayfever, allergic rhinitis or eczema	3.3	7.1	7.8	-2.5	-2.8
Qualifications: College or University degree	3.2	10.0	11.3	2.9	3.4
Respiratory disease	2.7	6.1	6.7	-2.6	-2.4
Age at last live birth	2.7	3.9	4.8	2.2	1.7
Medication: Atorvastatin	2.7	3.3	3.8	-1.7	-2.0
Bipolar Disorder or Schizophrenia	2.5	6.2	6.9	-2.6	-2.3
Number of children fathered	2.5	2.8	2.9	1.7	1.7
Miserableness	2.5	4.4	5.5	-1.8	-2.4
Depressed Affect (Nagel 2018)	2.4	5.0	6.4	-1.9	-2.5
Age at first live birth	2.4	4.2	4.9	1.9	2.2
Heart disease (mother)	2.4	2.9	3.3	-1.6	-1.8
Pulse wave Arterial Stiffness index	2.3	2.7	3.2	-1.5	-1.8
Breastfed as a baby	2.3	2.9	3.5	-1.9	-1.5
Ever used hormone-replacement therapy (HRT)	2.2	2.8	3.6	-1.4	-1.9
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	2.6	1.6	1.5
Allergy	2.2	5.1	5.3	2.2	2.3
Headache pain in last month	2.2	3.7	4.1	-2.0	-1.8
Medication: Ventolin 100micrograms inhaler	2.2	2.9	3.1	-1.6	-1.8
Suffer from ‘nerves’	2.2	3.5	3.7	1.8	1.9
Maternal smoking around birth	2.1	3.0	4.0	-1.4	-2.0
Exposure to tobacco smoke outside home	2.1	2.8	3.3	1.8	1.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	3.6	1.8	1.9
Medication for cholesterol	2.1	3.2	3.9	1.6	2.0
Breast Cancer	2.0	4.8	5.8	-2.0	-2.4
Hand grip strength (left)	2.0	5.3	6.8	-2.0	-2.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	2.4	-1.5	-1.6
Lung cancer (father)	2.0	2.3	2.3	1.5	1.5
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.4	1.5	1.4
Hand grip strength (right)	1.8	5.0	5.2	-2.2	-2.3
Fed-up feelings	1.8	3.3	4.7	-1.4	-2.2
Length of working week for main job	1.8	2.0	2.2	1.5	1.3
Pulse wave peak to peak time	1.8	2.1	2.6	1.3	1.6
Bipolar Disorder (2018)	1.7	2.7	3.5	-1.9	-1.4
Schizophrenia (2018)	1.7	3.5	3.5	-1.9	-1.9
Blood Eosinophil Count	1.7	13.3	15.4	-3.9	-3.3
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	3.5	-1.5	-1.9
Comparative body size at age 10	1.7	4.6	5.5	1.9	2.3
Financial difficulties in last 2 years	1.6	2.1	2.8	-1.2	-1.7
Ever highly irritable/argumentative for 2 days	1.6	2.0	2.7	-1.1	-1.6
Wheeze or whistling in the chest in last year	1.6	2.8	2.9	-1.6	-1.7
Osteoporosis (self-reported)	1.6	2.0	2.5	1.6	1.3
Irritable Bowel Disease (IBD)	1.5	3.6	4.2	-1.7	-2.1
Illnesses of father: Heart disease	1.5	2.1	2.5	-1.6	-1.3
Medication: Blood pressure	1.5	2.8	3.1	-1.6	-1.8
Commuting to job workplace: Cycle	1.5	1.8	2.4	1.0	1.6
Blood White Count	1.4	10.7	11.8	-3.1	-3.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.0	-1.4	-1.4
Diabetes (mother)	1.4	1.7	1.9	1.2	1.4
Relative age voice broke	1.4	2.1	2.8	1.7	1.2
Serious illness, injury or assault to yourself	1.4	1.7	1.8	-1.3	-1.3
Illnesses of siblings	1.4	1.9	2.3	1.5	1.2
High cholesterol (Self-reported)	1.4	2.5	3.2	-1.3	-1.8
Ever smoked	1.4	2.5	3.0	-1.4	-1.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	1.9	-1.1	-1.4
Depression (Nagel 2018)	1.3	1.9	2.0	-1.4	-1.4
Fluid intelligence score	1.3	2.7	3.7	1.3	1.9
Loud music exposure frequency	1.3	1.4	1.8	-1.0	-1.4
Risk taking	1.3	2.0	2.2	1.3	1.5
Fractured/broken bones in last 5 years	1.3	1.6	2.7	-0.7	-1.6
Myopia	1.3	1.8	2.4	-1.1	-1.5
Primary Biliary Cirrhosis	1.2	1.8	2.8	1.7	0.9
Schizophrenia (2014)	1.2	2.6	2.7	-1.6	-1.6
Type 2 Diabetes (T2D) (2018)	1.2	2.2	2.6	-1.3	-1.6
Supplements: Vitamin C	1.2	1.5	1.5	1.2	1.2
Smoking status: Previous	1.2	1.8	2.2	-1.2	-1.5
Crohns Disease (2017)	1.1	2.4	3.3	-1.2	-1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.8	-1.3	-0.9
Qualifications: None of the above	1.1	2.3	3.2	-1.2	-1.8
Asthma	1.1	2.2	2.6	-1.6	-1.4
Number of operations (self-reported)	1.1	1.6	2.0	1.4	1.1
Prostate Cancer	1.0	1.4	1.6	1.1	1.3
Blood clot in the leg (DVT)	1.0	1.3	1.7	1.3	1.0
Medication for pain relief, constipation, heartburn	1.0	1.7	2.2	-1.1	-1.5
Knee pain experienced in last month	1.0	1.5	1.5	1.2	1.2
Ever had bowel cancer screening	1.0	1.2	1.3	-1.1	-1.1
Asthma (self-reported)	1.0	2.0	2.3	-1.5	-1.3
Number of self-reported non-cancer illnesses	1.0	1.7	2.0	-1.4	-1.2
Heart disease (siblings)	1.0	1.2	1.3	-1.1	-1.1
Intelligence (Savage-Jansen 2018)	0.9	2.7	3.2	1.5	1.8
Major Depression (MDD)	0.9	1.1	2.0	1.4	0.6
Illnesses of siblings: Diabetes	0.9	1.1	1.4	-1.2	-0.9
Hearing aid user	0.9	1.1	1.1	-1.0	-1.0
Age started oral contraceptive pill	0.9	1.1	1.6	0.8	1.2
Cholesterol lowering medication	0.9	1.4	1.8	-0.9	-1.4
Ulcerative Colitis (UC)	0.8	1.5	1.6	-1.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.2	1.2	1.5
Severe depression (siblings)	0.8	0.8	0.9	0.9	1.0
Past tobacco smoking	0.8	1.5	2.0	1.0	1.4
High blood pressure (siblings)	0.8	1.2	1.4	-1.2	-1.0
Leg pain on walking	0.8	0.9	1.0	0.9	1.0
Qualifications: nursing, teaching	0.8	1.3	1.6	1.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.3	1.1	0.9
BMI	0.7	4.1	4.8	2.2	1.8
Ever had hysterectomy (womb removed)	0.7	0.8	1.0	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.1	-0.8	-1.0
Medication: Ibuprofen	0.7	0.9	1.0	0.8	1.0
Eye problems/disorders: Cataract	0.7	0.8	1.0	0.8	1.0
Average weekly champagne plus white wine intake	0.7	1.0	1.2	-0.9	-1.1
Systolic blood pressure, automated reading	0.6	1.9	1.9	-1.4	-1.3
Medication: Metformin	0.6	0.9	1.0	1.0	0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.0	-1.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.6	-0.6	-1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	0.8	-0.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	0.9	0.9	0.9
Worry too long after embarrassment	0.6	0.9	1.0	1.0	0.9
Neck or shoulder pain in last month	0.6	0.9	1.2	-0.7	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	0.7	-0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	0.9	0.7	1.0
Average weekly red wine intake	0.6	0.9	1.3	0.7	1.1
Back pain experienced in last month	0.6	0.9	1.1	1.0	0.8
Crohns Disease (2012)	0.5	0.9	1.4	-0.6	-1.2
Blood Platelet Count	0.5	5.5	7.1	2.7	2.0
Angina	0.5	0.7	0.9	-0.7	-0.9
Number of live births	0.5	0.7	1.4	-0.2	-1.2
Impedance of arm (left)	0.5	2.4	2.8	-1.5	-1.7
Angina (self-reported)	0.5	0.7	0.8	-0.7	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.6	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	-0.9	-0.5
Wears glasses or contact lenses	0.5	0.6	0.6	0.8	0.7
Alzheimer’s Disease (in father)	0.4	0.4	0.5	-0.6	-0.7
LDL Cholesterol	0.4	0.6	0.7	0.9	0.6
Ulcerative Colitis	0.4	0.7	0.7	-0.8	-0.8
Average weekly fortified wine intake	0.4	0.5	0.8	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.5	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	0.4	-0.7	-0.7
Number of incorrect matches in round	0.4	0.6	1.0	-1.0	-0.4
Impedance of arm (right)	0.4	1.7	2.0	-1.2	-1.4
Hip circumference	0.4	1.8	2.7	1.6	1.0
Depression (self-reported)	0.4	0.5	0.7	-0.8	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	1.1	0.8	1.0
Medication: Amlodipine	0.4	0.5	0.7	-0.6	-0.8
Number of full brothers	0.4	0.5	0.8	-0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.5	-0.7	-0.6
Family relationship satisfaction	0.4	0.4	0.7	0.9	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.5	-0.7	-0.6
Friendships satisfaction	0.4	0.5	0.7	0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.6	0.6	0.8
Osteoarthritis (self-reported)	0.4	0.5	0.7	0.8	0.6
Medication: Gliclazide	0.4	0.4	0.4	0.6	0.7
Average weekly beer plus cider intake	0.4	0.6	0.7	0.7	0.9
Supplements: Calcium	0.4	0.5	0.7	-0.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.6	-0.7	-0.8
Impedance of whole body	0.4	2.1	2.3	-1.4	-1.5
Bipolar Disorder (2011)	0.3	0.3	0.4	-0.6	-0.4
Triglycerides	0.3	0.5	0.7	-0.8	-0.6
Medication: Co-codamol	0.3	0.3	0.4	0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.1	-1.0	-0.6
Impedance of leg (left)	0.3	1.6	1.6	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	-1.0	-0.5
Mouth/teeth dental problems	0.3	0.4	0.7	-0.8	-0.4
Illnesses of mother	0.3	0.4	0.6	0.4	0.8
Tense / ‘highly strung’	0.3	0.5	0.5	0.7	0.7
Birth weight	0.3	0.6	1.0	1.0	0.4
Migraine (self-reported)	0.3	0.4	0.7	-0.9	0.0
Overall health rating	0.3	0.6	0.6	-0.8	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	0.4	0.7
Alcohol drinker status: Previous	0.3	0.4	0.5	-0.7	-0.5
Age at First Birth	0.2	0.3	0.6	0.3	0.7
Height	0.2	4.7	5.8	-1.9	-2.4
Cardiovascular Disease	0.2	0.7	1.0	-0.6	-1.0
Lung FEV1/FVC ratio	0.2	0.9	1.0	0.9	1.0
Neuroticism	0.2	0.5	0.6	-0.6	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.6	0.4
Impedance of leg (right)	0.2	1.1	1.1	-1.0	-1.0
Age when periods started (menarche)	0.2	0.5	0.8	-0.4	-0.9
High blood pressure	0.2	0.4	0.6	-0.5	-0.8
Multivitamins +/- minerals	0.2	0.3	0.3	-0.5	-0.5
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.7	0.5
High blood pressure (mother)	0.2	0.2	0.4	-0.1	-0.6
Body mass index (BMI)	0.2	1.0	1.3	1.2	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	0.4	0.6
Diabetes (self-reported)	0.2	0.2	0.4	0.6	0.3
Worrier / anxious feelings	0.2	0.4	0.6	0.4	0.8
Falls in the last year	0.2	0.2	0.4	-0.2	-0.6
Pulse rate	0.2	0.3	0.5	0.7	0.5
Medication: Cholesterol lowering	0.2	0.3	0.4	-0.5	-0.6
Standing height	0.2	2.1	2.5	-1.3	-1.6
Peak expiratory flow (PEF)	0.2	0.6	0.9	0.9	0.5
Pulse wave reflection index	0.2	0.2	0.2	-0.5	-0.4
Medication: Paracetamol	0.2	0.4	0.4	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.7	-0.3
Mean time to correctly identify matches	0.2	0.4	0.8	-0.9	-0.2
Mood swings	0.2	0.4	0.7	-0.4	-0.8
Guilty feelings	0.2	0.3	0.5	0.7	0.4
Mother’s age at death	0.2	0.2	0.3	-0.3	-0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.7	0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.4	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.5	0.0
Worry (Nagel 2018)	0.1	0.1	0.2	-0.4	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	0.3	0.3
Reaction Time	0.1	0.1	0.2	-0.2	0.5
Ovarian Cancer	0.1	0.1	0.1	0.3	-0.2
HDL Cholesterol	0.1	0.2	0.3	0.6	-0.3
Lupus	0.1	0.1	0.1	0.3	-0.4
Neuroticism (2016)	0.1	0.1	0.2	0.4	0.3
Heel T-Score	0.1	1.1	1.6	-1.3	-0.7
Waist Hip Ratio (WHR)	0.1	0.4	0.6	-0.8	-0.4
Systolic Blood Pressure	0.1	0.5	0.7	-0.8	-0.5
Smoking Status	0.1	0.2	0.5	-0.1	-0.7
Chronotype (morning person)	0.1	0.3	0.5	0.4	0.7
Tanning	0.1	0.8	1.3	-1.2	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.5
Diabetes (father)	0.1	0.1	0.2	-0.4	-0.2
Trunk fat percentage	0.1	0.5	0.9	-0.3	-1.0
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.5	-0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	-0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.2	-0.5	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.4	-0.2
Sitting height	0.1	1.0	1.0	-1.0	-1.0
Trunk fat mass	0.1	0.4	0.7	-0.2	-0.9
Heart attack	0.1	0.2	0.2	-0.4	-0.4
Medication: Ramipril	0.1	0.1	0.2	0.5	0.2
Medication: Simvastatin	0.1	0.1	0.2	-0.0	-0.5
Time employed in main current job	0.1	0.2	0.3	-0.2	-0.6
Father’s age at death	0.1	0.2	0.2	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.4	0.7	0.7
Prospective memory result	0.1	0.1	0.1	0.4	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.2	0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.0	-0.5
Body fat percentage	0.1	0.3	0.6	-0.2	-0.8
Health satisfaction	0.1	0.1	0.2	-0.2	-0.4
Pulse rate, automated reading	0.1	0.3	0.5	0.7	0.5
Alcohol intake frequency.	0.1	0.2	0.3	0.6	0.2
Comparative height size at age 10	0.1	0.7	0.9	-0.8	-0.9
Chest pain or discomfort	0.1	0.1	0.3	0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	0.0
Mineral and other dietary supplements	0.1	0.1	0.1	0.4	0.0
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	0.3	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.3	0.4
Medication: Paracetamol	0.1	0.2	0.2	-0.4	-0.4
Medication: Lisinopril	0.1	0.2	0.3	0.5	0.4
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	0.2
Irritability	0.1	0.2	0.3	-0.1	-0.6
Diastolic blood pressure, automated reading	0.1	0.2	0.2	-0.5	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3
Pain experienced in last month	0.1	0.2	0.3	0.2	0.5
Pack years of smoking	0.1	0.2	0.2	-0.5	-0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.1	0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.0
Mean Putamen Volume	0.0	0.0	0.0	0.0	0.2
Fasting Glucose	0.0	0.0	0.1	-0.3	-0.0
Rheumatoid Arthritis	0.0	0.0	0.0	-0.2	-0.2
Hypothyroidism (self reported)	0.0	0.1	0.2	0.4	0.0
Lung FVC	0.0	0.2	0.3	-0.3	-0.5
Hair Pigment	0.0	0.0	0.1	0.1	-0.3
Number of treatments/medications taken	0.0	0.1	0.1	0.3	0.2
Relative age of first facial hair	0.0	0.0	0.0	0.2	-0.1
Vitamin and mineral supplements	0.0	0.1	0.1	0.1	0.3
Supplements: Zinc	0.0	0.0	0.0	-0.1	0.1
Pack years adult smoking proportion	0.0	0.0	0.0	-0.2	-0.0
Leg fat-free mass (left)	0.0	0.1	0.2	0.5	0.1
Current tobacco smoking	0.0	0.0	0.1	0.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.0	-0.2
Taking other prescription medications	0.0	0.0	0.0	-0.0	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.0
Leg predicted mass (left)	0.0	0.1	0.2	0.5	0.1
Waist circumference	0.0	0.1	0.3	0.5	0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	-0.1
Nervous feelings	0.0	0.0	0.0	-0.1	0.1
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.3	0.1
Pain all over the body in last month	0.0	0.0	0.0	-0.0	-0.1
Neuroticism score	0.0	0.0	0.0	0.2	0.0
Weight	0.0	0.1	0.3	0.5	-0.0
Arm fat percentage (right)	0.0	0.1	0.1	0.2	-0.4
Trunk fat-free mass	0.0	0.1	0.1	0.3	0.0
Alcohol intake versus 10 years previously	0.0	0.1	0.1	0.1	0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.2	0.0
Happiness	0.0	0.0	0.0	0.1	-0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.3	0.2
Arm fat mass (right)	0.0	0.1	0.2	0.4	-0.1
Trunk predicted mass	0.0	0.1	0.2	0.4	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.1	-0.0
Birth weight of first child	0.0	0.1	0.1	-0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.2	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.0	-0.0	-0.2
Leg fat percentage (right)	0.0	0.1	0.1	0.3	-0.2
Arm fat-free mass (right)	0.0	0.0	0.1	0.3	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	0.1
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.0	-0.0
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.2	0.2
Medication: Blood pressure	0.0	0.1	0.1	0.3	0.2
Medication: Omeprazole	0.0	0.0	0.1	-0.3	0.1
Whole body fat mass	0.0	0.2	0.4	-0.0	-0.6
Leg fat mass (right)	0.0	0.1	0.2	0.1	-0.4
Arm predicted mass (right)	0.0	0.0	0.1	0.1	-0.3
Number of full sisters	0.0	0.0	0.1	0.1	-0.2
Had major operations	0.0	0.0	0.0	0.0	-0.1
Medication: Aspirin	0.0	0.1	0.1	-0.3	0.0
Hypertension (Self-reported)	0.0	0.1	0.2	-0.2	-0.5
Whole body fat-free mass	0.0	0.1	0.2	0.4	0.0
Leg fat-free mass (right)	0.0	0.1	0.1	0.3	-0.0
Arm fat percentage (left)	0.0	0.1	0.1	0.2	-0.3
Loneliness, isolation	0.0	0.1	0.1	0.3	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.2	-0.3
Diabetes diagnosed by doctor	0.0	0.1	0.1	0.3	-0.0
Medication: Aspirin	0.0	0.0	0.1	-0.2	0.1
Smoking status: Current	0.0	0.1	0.1	0.3	0.2
Whole body water mass	0.0	0.1	0.2	0.4	0.0
Leg predicted mass (right)	0.0	0.1	0.1	0.4	0.0
Arm fat mass (left)	0.0	0.1	0.1	0.3	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.0	-0.0
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.0	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	-0.2
Basal metabolic rate	0.0	0.1	0.3	0.5	0.1
Leg fat percentage (left)	0.0	0.1	0.1	0.2	-0.3
Arm fat-free mass (left)	0.0	0.1	0.3	0.5	0.2
Ever depressed for a whole week	0.0	0.0	0.0	0.2	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.2	0.4
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.3	0.0
Leg fat mass (left)	0.0	0.2	0.3	0.0	-0.6
Arm predicted mass (left)	0.0	0.0	0.1	0.1	-0.3

Hub : Genes

RPS6KA4

Models

Trait associations