TWAS hub - RRAGC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0539	0.0225	0.0051	0.009	0.015	0.001	0.015	0.003	0.021	0.0044	0.240	0.004	0.130
2	TCGA	Lung Adenocarcinoma	0.0314	0.0210	0.0034	0.012	0.020	0.004	NA	0.005	0.013	0.0018	0.094	NA	0.076

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Diabetes diagnosed by doctor	7.5	12.4	18.1	4.2	2.6
Type 2 Diabetes (T2D) (2018)	6.3	11.8	14.7	3.8	3.0
Diabetes (self-reported)	6.0	9.3	16.9	4.1	1.3
HDL Cholesterol	5.4	9.1	17.9	-4.2	-0.5
Medication: Metformin	5.3	7.4	12.4	3.5	1.6
Happiness	4.6	5.5	8.8	-1.5	-3.0
Ovarian Cancer	4.5	5.9	9.9	3.1	-1.4
Heart attack/myocardial infarction (self-reported)	4.0	5.1	7.5	2.7	1.6
Prostate Cancer	3.9	5.5	10.3	3.2	-0.8
Hearing difficulty/problems: Yes	3.7	5.7	9.4	-3.1	1.4
Medication for cholesterol	3.1	4.6	5.7	-2.4	-1.9
Blood White Count	3.0	22.0	36.0	2.8	6.0
Family relationship satisfaction	3.0	3.7	6.5	-1.0	-2.5
Maternal smoking around birth	2.9	4.2	8.4	0.3	2.9
Medication: Aspirin	2.9	3.9	4.7	1.7	2.2
Waist Hip Ratio (WHR)	2.8	12.6	15.8	3.1	4.0
Heart attack	2.8	3.6	5.4	2.3	1.4
Rheumatoid Arthritis	2.7	3.7	6.6	-0.9	-2.6
Medication: Gliclazide	2.7	3.0	6.1	2.5	-0.1
Medication: Aspirin	2.6	3.4	4.0	1.7	2.0
Ever had hysterectomy (womb removed)	2.5	2.8	5.2	-2.3	-0.7
Severe depression (siblings)	2.4	2.6	2.9	-1.7	-1.5
Financial difficulties in last 2 years	2.3	3.1	3.5	1.9	-1.6
Ever highly irritable/argumentative for 2 days	2.3	2.7	3.1	-1.8	-1.5
Birth weight	2.3	5.1	10.0	-3.2	0.3
Pulse rate, automated reading	2.3	7.3	13.5	3.7	1.1
Loneliness, isolation	2.3	3.1	3.3	-1.7	-1.8
Friendships satisfaction	2.3	2.9	3.0	-1.7	-1.7
Number of children fathered	2.2	2.5	3.5	-1.2	-1.9
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.9	2.0	-0.9
Medication: Ramipril	2.1	2.7	3.3	1.4	1.8
Commuting to job workplace: Car/motor vehicle	2.1	2.5	4.0	-2.0	0.9
Commuting to job workplace: Public transport	2.1	2.6	2.7	1.6	-1.6
Pain experienced in last month	2.0	3.3	4.3	-1.5	2.1
Type 2 Diabetes (T2D) (2012)	1.9	2.2	2.6	1.6	1.3
Medication: Atenolol	1.9	2.4	3.8	2.0	0.9
Alcohol intake versus 10 years previously	1.9	2.8	3.6	1.9	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	2.7	1.4	1.6
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.2	0.4	2.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.0	1.4	1.7
Diabetes (father)	1.8	2.2	4.4	2.1	-0.1
Hearing difficulty/problems with background noise	1.8	2.8	5.5	-2.4	0.3
Mineral and other dietary supplements	1.8	2.4	2.6	-1.6	-1.5
Ever used hormone-replacement therapy (HRT)	1.7	2.2	2.5	-1.4	-1.6
Had other major operations	1.7	2.1	3.4	-1.9	0.9
Commuting to job workplace: Walk	1.7	1.8	2.8	1.7	-0.9
Fractured/broken bones in last 5 years	1.7	2.2	4.0	-2.0	0.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.9	-1.7	1.0
Chronic bronchitis/emphysema (father)	1.6	1.9	3.0	-0.9	-1.7
Medication: Simvastatin	1.6	2.4	3.0	1.7	1.4
Mouth/teeth dental problems: Dentures	1.6	2.7	3.8	1.3	2.0
Cholesterol lowering medication	1.6	2.4	2.6	1.6	1.5
Alcohol drinker status: Previous	1.6	1.8	2.9	-0.8	1.7
Average weekly spirits intake	1.5	1.9	3.6	0.3	1.9
Glaucoma (self-reported)	1.5	1.7	3.4	1.9	-0.2
Neck or shoulder pain in last month	1.5	2.2	2.4	1.5	-1.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	2.5	-1.6	1.1
Supplements: Calcium	1.5	1.6	2.2	-1.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	4.6	2.1	-1.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.8	-1.7	1.0
Prospective memory result	1.4	1.7	3.3	0.1	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	1.7	-1.3	-1.3
Hearing aid user	1.4	1.6	2.2	-1.5	-1.0
Diabetes (mother)	1.3	1.6	3.0	1.7	0.4
Impedance of leg (left)	1.3	6.2	12.2	-3.5	0.3
Alcohol intake frequency.	1.3	3.1	6.1	0.2	2.5
Leg pain on walking	1.3	1.6	2.8	-1.7	0.6
Pack years of smoking	1.3	1.9	3.2	1.8	0.8
Alzheimer’s Disease (in mother)	1.2	1.4	2.8	0.2	-1.7
Systolic blood pressure, automated reading	1.2	3.5	6.6	0.7	2.6
Impedance of leg (right)	1.2	6.1	12.0	-3.5	0.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.4	-1.2	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	2.2	-1.2	-1.5
Illnesses of mother	1.2	1.5	2.0	-1.0	1.4
Breastfed as a baby	1.2	1.5	2.9	-1.7	0.2
Worry too long after embarrassment	1.2	2.0	3.4	-0.8	-1.8
Leg fat-free mass (right)	1.2	6.5	12.8	3.6	-0.3
Illnesses of father: None of the above (group 1)	1.2	1.5	1.6	-1.1	1.3
Mother’s age at death	1.2	1.5	2.3	-0.9	-1.5
Vascular/heart problems diagnosed by doctor	1.2	3.4	3.6	-1.8	-1.9
Bipolar Disorder (2018)	1.1	1.8	2.6	-1.6	-0.9
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.1	-0.2	-1.8
Angina	1.1	1.5	2.4	1.5	0.7
Leg fat-free mass (left)	1.1	5.8	11.4	3.4	-0.3
Stomach or abdominal pain in last month	1.1	1.4	2.2	-0.7	-1.5
Headache pain in last month	1.1	1.8	3.1	1.8	-0.7
Angina (self-reported)	1.1	1.5	2.2	1.5	0.9
Ever had bowel cancer screening	1.1	1.3	1.3	-1.1	1.1
Leg predicted mass (right)	1.1	6.0	12.0	3.5	-0.3
Schizophrenia vs Biploar Disorder	1.0	1.3	1.4	-1.1	-1.2
Systolic Blood Pressure	1.0	5.1	9.8	0.6	3.1
Pack years adult smoking proportion	1.0	1.6	2.8	1.7	0.6
Leg predicted mass (left)	1.0	5.3	10.6	3.3	-0.3
Forced vital capacity (FVC)	1.0	4.0	6.0	2.4	-1.5
Fluid intelligence score	1.0	2.0	3.7	1.9	-0.6
Arm fat percentage (right)	1.0	3.9	7.0	0.8	-2.7
Father’s age at death	1.0	1.3	2.2	-0.6	-1.5
High blood pressure (siblings)	1.0	1.5	1.5	1.2	1.2
Arm fat percentage (left)	1.0	3.8	6.7	1.0	-2.6
Medication: Blood pressure	1.0	2.0	2.5	1.6	1.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.6	1.0	1.2
Age started oral contraceptive pill	1.0	1.3	2.4	-0.3	1.6
Blood Red Count	0.9	8.5	11.0	2.5	3.3
Hand grip strength (left)	0.9	2.3	3.6	1.9	1.0
Number of treatments/medications taken	0.9	1.6	2.2	1.5	1.0
Townsend deprivation index at recruitment	0.9	1.2	1.4	1.2	-1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.6	1.9	-0.5
Trunk fat-free mass	0.9	5.0	8.2	2.9	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	4.2	2.0	-1.3
Peak expiratory flow (PEF)	0.9	2.0	3.9	0.2	-2.0
Eye problems/disorders: None of the above	0.9	1.1	1.9	-1.4	0.4
Medication: Omeprazole	0.9	1.1	1.6	1.3	0.7
Medication: Seretide 50 evohaler	0.9	1.0	1.8	-0.4	-1.3
Knee pain experienced in last month	0.9	1.4	2.5	1.6	0.5
Breast cancer (self-reported)	0.9	1.1	1.8	-0.5	1.4
Guilty feelings	0.9	1.4	2.6	-1.6	-0.4
Medication: Atorvastatin	0.9	1.1	1.6	0.8	1.3
Number of operations (self-reported)	0.9	1.3	1.4	-1.1	1.2
Impedance of whole body	0.9	4.7	8.2	-2.9	-1.1
Neuroticism (2016)	0.8	1.1	1.6	-1.3	-0.8
Trunk fat percentage	0.8	3.2	6.3	0.4	-2.5
Hand grip strength (right)	0.8	2.2	4.4	2.1	0.3
High blood pressure	0.8	2.2	2.9	1.2	1.7
Sitting height	0.8	5.3	10.1	3.2	0.7
Waist circumference	0.8	3.1	6.1	2.5	-0.2
Falls in the last year	0.8	1.0	1.9	-0.4	1.4
Medication: Cholesterol lowering	0.8	1.3	1.3	1.1	1.1
Trunk predicted mass	0.8	4.8	7.6	2.8	1.4
Exposure to tobacco smoke at home	0.8	0.9	1.6	-0.4	1.2
Number of full sisters	0.8	0.9	1.0	1.0	-0.9
Whole body fat-free mass	0.8	4.7	8.9	3.0	0.8
Average weekly red wine intake	0.8	1.3	1.4	-1.0	-1.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.1	-1.0	-1.1
Back pain experienced in last month	0.8	1.1	2.2	-0.0	-1.5
Osteoporosis (self-reported)	0.8	1.0	1.8	-1.4	-0.4
Whole body water mass	0.8	4.7	8.9	3.0	0.7
Medication: Paracetamol	0.8	1.2	2.0	0.6	1.4
Basal metabolic rate	0.8	4.3	8.5	2.9	0.3
Basal cell carcinoma (self-reported)	0.8	0.9	1.0	1.0	0.9
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.6	0.9	-1.9
Alzheimer’s Disease (in father)	0.7	0.7	1.5	0.1	-1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	0.5	-1.4
Blood Platelet Count	0.7	8.3	15.4	1.0	3.9
BMI	0.7	4.1	4.7	2.2	-1.9
Allergy or Eczema	0.7	1.9	3.8	-1.9	0.0
Hypothyroidism (self reported)	0.7	1.7	2.6	-1.6	-0.8
Neuroticism	0.7	1.8	3.0	-0.8	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.9	-0.1	-1.4
Neuroticism score	0.7	1.5	2.0	-0.9	-1.4
Weight	0.7	3.2	5.6	2.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.8	1.3	-0.6
Tense / ‘highly strung’	0.7	1.1	1.8	-0.7	1.3
Birth weight of first child	0.7	1.2	2.2	1.5	0.5
Loud music exposure frequency	0.7	0.7	1.2	0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.6	0.5	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	4.3	2.1	-0.8
Body fat percentage	0.7	2.7	5.5	0.1	-2.3
Arm predicted mass (right)	0.7	3.4	6.4	2.5	0.7
Suffer from ‘nerves’	0.7	1.1	1.4	-0.9	-1.2
Risk taking	0.7	1.1	1.8	-0.6	-1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	0.8	-0.9	-0.9
Neuroticism (Nagel 2018)	0.6	1.5	1.8	-1.1	-1.4
Crohns Disease (2017)	0.6	1.3	2.4	1.6	0.5
Irritable Bowel Disease (IBD)	0.6	1.5	2.7	1.6	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.0	0.8	-1.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	1.2	0.5
Cardiovascular Disease	0.6	2.0	3.1	1.8	1.0
Sensitivity / hurt feelings	0.6	1.1	2.0	-0.4	-1.4
Relative age voice broke	0.6	0.9	1.2	-0.7	-1.1
Trunk fat mass	0.6	2.7	4.1	1.1	-2.0
Had menopause	0.6	0.7	1.4	0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	0.9	-0.9	-0.7
Number of live births	0.6	0.9	1.7	1.3	-0.1
Pulse rate	0.6	1.0	1.7	1.3	0.6
Noisy workplace	0.6	0.8	1.0	1.0	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.0	1.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.3	1.8	-0.5
Arm fat mass (right)	0.6	2.4	2.8	1.4	-1.7
Arm fat-free mass (right)	0.6	2.9	5.0	2.2	0.9
Hypertension (Self-reported)	0.6	1.7	1.8	1.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	0.3	1.1
Financial situation satisfaction	0.6	0.8	1.4	-0.4	-1.2
Eye problems/disorders: Glaucoma	0.6	0.8	1.5	1.2	0.2
Medication: Lisinopril	0.6	0.8	0.8	0.9	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	1.1	0.4
Heart disease (siblings)	0.6	0.8	1.0	0.8	1.0
Lupus	0.5	0.8	1.1	0.7	-1.0
Medication: Co-codamol	0.5	0.6	0.9	0.5	0.9
Taking other prescription medications	0.5	0.7	1.1	-0.5	-1.1
High blood pressure (mother)	0.5	0.7	1.0	1.0	-0.6
Body mass index (BMI)	0.5	2.0	2.1	1.5	-1.4
Illnesses of siblings	0.5	0.7	1.3	-1.1	-0.3
Impedance of arm (right)	0.5	2.3	2.6	-1.4	-1.6
Hip circumference	0.5	2.2	2.3	1.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-0.1	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.8	0.6	-0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.4	-0.6	-1.2
Medication: Amlodipine	0.5	0.7	1.1	-0.5	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.5	-0.9
Exposure to tobacco smoke outside home	0.5	0.7	1.3	1.2	-0.3
Comparative body size at age 10	0.5	1.4	2.7	-0.3	1.6
Number of full brothers	0.5	0.7	0.9	0.7	-0.9
Medication: Blood pressure	0.5	0.9	1.5	0.6	1.2
Mean time to correctly identify matches	0.5	0.9	1.4	-1.2	0.6
Whole body fat mass	0.5	2.1	3.2	1.0	-1.8
Comparative height size at age 10	0.5	2.9	4.9	0.9	2.2
Overall health rating	0.5	1.0	1.0	1.0	1.0
Chest pain or discomfort	0.5	0.7	0.9	1.0	-0.7
Long-standing illness, disability or infirmity	0.5	0.7	1.4	1.2	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.0	-1.0	-0.8
Arm fat mass (left)	0.5	2.2	2.6	1.3	-1.6
Alcohol drinker status: Never	0.5	0.6	0.8	-0.5	0.9
Arm predicted mass (left)	0.5	2.3	4.5	2.1	0.5
Depressed Affect (Nagel 2018)	0.4	0.8	1.7	-0.0	-1.3
Fasting Glucose	0.4	0.5	0.9	0.3	0.9
Ulcerative Colitis	0.4	0.6	0.6	-0.7	0.8
Relative age of first facial hair	0.4	0.8	1.5	0.2	-1.2
Vitamin and mineral supplements	0.4	0.5	0.6	-0.8	0.6
Average weekly fortified wine intake	0.4	0.5	1.0	0.2	1.0
Age when periods started (menarche)	0.4	0.9	1.6	-0.4	-1.3
Time employed in main current job	0.4	0.5	0.7	-0.9	-0.5
Worrier / anxious feelings	0.4	0.7	1.1	-1.0	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-1.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.6	0.6	-0.8
Impedance of arm (left)	0.4	2.0	2.2	-1.3	-1.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.1	-1.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.9	-0.6
Wheeze or whistling in the chest in last year	0.4	0.6	1.3	-0.0	-1.1
Medication: Allopurinol	0.4	0.5	0.9	-0.2	1.0
Had major operations	0.4	0.4	0.7	0.3	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	-0.5	-0.9
Arm fat-free mass (left)	0.4	2.0	3.7	1.9	0.6
Average weekly beer plus cider intake	0.4	0.5	1.0	1.0	-0.2
Commuting to job workplace: Cycle	0.4	0.4	0.8	0.3	-0.9
Leg fat mass (left)	0.4	1.4	1.8	1.0	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.6	0.9	-0.9	-0.6
Depression (Nagel 2018)	0.3	0.4	0.8	-0.1	-0.9
Worry (Nagel 2018)	0.3	0.6	0.7	-0.8	-0.7
Heel T-Score	0.3	2.0	3.1	1.0	-1.8
Lung FVC	0.3	1.5	2.1	1.5	-0.9
Supplements: Glucosamine	0.3	0.4	0.7	0.9	0.1
Alcohol usually taken with meals	0.3	0.5	0.9	-1.0	-0.1
Mouth/teeth dental problems	0.3	0.4	0.5	-0.7	-0.6
Pain all over the body in last month	0.3	0.3	0.6	-0.8	0.3
Medication: Lansoprazole	0.3	0.4	0.4	-0.6	-0.6
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.2	-0.8
Leg fat percentage (right)	0.3	1.1	2.0	-0.4	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.1	-0.8
Age at first live birth	0.3	0.5	1.0	0.2	-1.0
Pulse wave peak to peak time	0.3	0.3	0.6	0.8	0.3
Leg fat mass (right)	0.3	1.2	1.7	0.8	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.0	-0.8
Mood swings	0.3	0.5	0.8	0.5	-0.9
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.9	0.1
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.9	0.5
Leg fat percentage (left)	0.3	1.1	2.1	-0.2	-1.4
Ever depressed for a whole week	0.3	0.3	0.4	0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.4	0.5	-0.7
Age at First Birth	0.2	0.3	0.5	0.3	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.3	-0.5
Mean Putamen Volume	0.2	0.2	0.3	0.6	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.3	-0.6	0.5
Blood Eosinophil Count	0.2	1.4	2.0	-0.9	1.4
Height	0.2	4.5	5.7	2.4	1.8
Respiratory disease	0.2	0.3	0.5	0.4	-0.7
Tanning	0.2	2.4	4.2	-2.0	0.8
Supplements: Zinc	0.2	0.2	0.4	-0.6	-0.0
Current tobacco smoking	0.2	0.3	0.6	0.1	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	0.6
Multivitamins +/- minerals	0.2	0.3	0.6	0.7	-0.3
Past tobacco smoking	0.2	0.5	0.9	0.2	0.9
Qualifications: None of the above	0.2	0.4	0.8	0.2	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	0.7	0.5
Standing height	0.2	2.0	3.0	1.7	1.0
Length of working week for main job	0.2	0.2	0.3	0.6	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.7	-0.3
Gout (self-reported)	0.2	0.3	0.5	-0.4	0.7
Health satisfaction	0.2	0.2	0.4	-0.6	-0.1
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.4	0.6
Qualifications: College or University degree	0.2	0.5	1.0	0.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.3	-0.6	0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.7	0.1
Medication: Ibuprofen	0.2	0.3	0.5	0.7	0.3
Age at last live birth	0.2	0.3	0.4	0.7	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	0.3	-0.7
Asthma (self-reported)	0.2	0.5	0.6	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.4	0.7	0.5
Miserableness	0.2	0.3	0.5	0.3	-0.7
Wears glasses or contact lenses	0.2	0.2	0.2	-0.5	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.1	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.5	0.4	0.7
Medication: Bendroflumethiazide	0.2	0.2	0.5	-0.2	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.8	-0.2
Irritability	0.2	0.4	0.6	-0.8	-0.4
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	-0.4
Ulcerative Colitis (UC)	0.1	0.3	0.5	0.3	0.7
Major Depression (MDD)	0.1	0.2	0.3	-0.6	-0.1
Reaction Time	0.1	0.1	0.2	-0.5	-0.1
Breast Cancer	0.1	0.3	0.3	-0.6	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.5	0.0
Crohns Disease (2012)	0.1	0.2	0.3	0.6	0.3
HbA1C	0.1	0.1	0.3	-0.1	0.5
Smoking Status	0.1	0.3	0.4	0.4	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.7	0.4
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.1
Hair Pigment	0.1	3.2	5.2	2.3	1.1
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.4	0.3
Fed-up feelings	0.1	0.2	0.2	0.4	-0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.3	-0.3
Number of incorrect matches in round	0.1	0.1	0.2	0.4	0.3
Nervous feelings	0.1	0.2	0.4	-0.1	0.6
Allergy	0.1	0.2	0.2	0.4	-0.5
Asthma	0.1	0.3	0.4	0.6	-0.4
Depression (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Lung cancer (father)	0.1	0.2	0.3	0.5	0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.6	0.1
Pulse wave reflection index	0.1	0.2	0.3	0.1	-0.6
Medication: Paracetamol	0.1	0.2	0.2	0.5	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	-0.4
Migraine (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Heart disease (mother)	0.1	0.1	0.1	0.3	-0.2
Smoking status: Previous	0.1	0.2	0.3	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	0.2	0.5
Qualifications: nursing, teaching	0.1	0.2	0.2	-0.5	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.1	0.4
Smoking status: Current	0.1	0.2	0.4	0.1	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.4	0.2
Ever smoked	0.1	0.2	0.2	-0.4	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.3	0.9
Myopia	0.1	0.1	0.2	0.4	0.2
Schizophrenia (2018)	0.0	0.0	0.0	0.2	0.0
LDL Cholesterol	0.0	0.1	0.1	-0.4	-0.1
Schizophrenia (2014)	0.0	0.0	0.1	-0.3	-0.1
Triglycerides	0.0	0.1	0.1	0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.1	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	-0.1	-0.2
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.4	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.2	0.1
Supplements: Vitamin C	0.0	0.0	0.1	0.1	0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

RRAGC

Models

Trait associations