Hub : Genes

RRP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.055	0.0240	6.6e-03	0.017	0.008	0.000	0.012	0.008	3.3e-03	0.0310	3.4e-01	0.012	3.6e-02
2	GTEx	Adipose Subcutaneous	0.182	0.0470	3.6e-06	0.095	NA	0.063	NA	0.041	3.7e-08	NA	7.5e-06	NA	2.6e-04
3	GTEx	Esophagus Gastroesophageal Junction	0.194	0.0750	3.6e-03	0.012	NA	-0.008	NA	-0.008	1.1e-01	NA	9.1e-01	NA	9.5e-01
4	GTEx	Esophagus Mucosa	0.189	0.0600	9.4e-04	0.011	NA	0.005	NA	0.015	6.0e-02	NA	1.3e-01	NA	3.0e-02
5	GTEx	Lung	0.118	0.0388	2.1e-04	0.044	NA	0.088	NA	0.090	2.6e-04	NA	3.0e-07	NA	2.3e-07
6	GTEx	Muscle Skeletal	0.151	0.0374	1.1e-06	0.052	NA	0.077	NA	0.040	7.1e-06	NA	5.6e-08	NA	7.9e-05
7	GTEx	Nerve Tibial	0.130	0.0415	6.0e-04	0.069	NA	0.026	NA	0.011	1.3e-05	NA	6.0e-03	NA	4.9e-02
8	GTEx	Skin Not Sun Exposed Suprapubic	0.227	0.0760	2.8e-03	0.107	NA	0.079	NA	0.095	1.8e-06	NA	4.2e-05	NA	6.7e-06
9	GTEx	Skin Sun Exposed Lower leg	0.151	0.0520	5.7e-04	0.016	NA	0.030	NA	0.022	1.6e-02	NA	1.4e-03	NA	5.6e-03
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.069	0.0380	3.2e-03	-0.001	0.038	0.024	NA	0.007	3.7e-01	0.0014	9.5e-03	NA	9.7e-02
11	TCGA	Stomach Adenocarcinoma	0.055	0.0330	6.4e-03	0.011	0.026	0.033	NA	0.017	4.7e-02	0.0053	1.9e-03	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	2.2	-1.4	-1.5	-0.5	-0.8	0.3	-0.6	0.2	-0.7	-0.9	-1.3	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-0.4	-0.4	0.9	0.5	0.7	0.0	1.0	-0.4	0.0	-1.1	-0.6
Depressed Affect (Nagel 2018)	1.3	2.6	7.5	1.4	2.3	0.3	0.4	2.7	1.9	2.1	1.5	1.3	-0.3	1.4
Depression (Nagel 2018)	0.7	1.1	3.1	0.2	1.1	1.2	0.5	1.7	1.6	-0.0	1.0	0.8	0.0	1.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	10.0	-0.5	-1.1	-0.7	-0.0	-1.0	-0.3	-0.5	-1.0	-3.2	-0.4	-1.1
Neuroticism (Nagel 2018)	1.2	2.7	5.8	0.9	2.3	0.4	1.0	2.4	2.1	1.6	1.9	1.2	-0.6	2.1
Schizophrenia (2018)	0.3	0.6	2.6	0.7	0.6	1.6	1.0	0.6	0.5	1.1	0.1	0.7	-0.4	-0.0
Schizophrenia vs Biploar Disorder	1.0	1.3	2.5	0.7	1.3	1.1	1.6	0.8	1.4	0.9	1.5	1.0	-0.4	1.2
Worry (Nagel 2018)	0.9	2.0	4.4	0.5	1.6	-0.0	0.6	2.0	1.8	1.2	1.4	1.4	-1.2	2.1
Alzheimer’s Disease (in mother)	5.2	6.1	11.8	2.2	3.4	0.7	2.0	3.1	3.1	2.6	2.3	3.0	0.5	2.4
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-1.0	-0.5	0.9	-0.1	1.2	0.3	0.3	0.3	0.6	-1.0	0.3
Alzheimer’s Disease (including proxy)	3.1	4.5	8.8	1.3	2.8	1.2	1.5	3.0	2.8	2.0	1.9	2.4	-0.2	2.5
Crohns Disease (2017)	1.0	2.2	8.8	0.4	-0.3	-1.6	-0.2	-1.7	-3.0	2.5	-1.1	-0.7	1.1	-1.0
Irritable Bowel Disease (IBD)	0.7	1.7	12.3	0.5	0.2	0.0	0.2	-1.1	-1.9	3.5	-0.6	0.5	0.9	-0.2
Ulcerative Colitis (UC)	0.8	1.5	11.4	0.7	0.6	1.3	0.5	-0.4	-0.2	3.4	0.2	1.2	0.1	0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.4	0.8	2.4	-0.8	-0.8	1.3	-0.7	0.4	-0.5	-0.8	-0.1	1.5	1.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.7	1.7	8.5	-0.5	-0.9	-0.6	-0.8	-1.9	-1.1	-0.7	-1.4	-2.9	-0.0	-1.1
Breast Cancer	0.5	1.1	5.8	2.4	1.1	-0.9	1.8	0.7	0.7	0.6	0.3	0.0	0.5	-0.0
Ovarian Cancer	0.7	1.0	2.7	1.6	1.3	0.1	1.2	0.1	1.1	1.0	0.0	1.1	-0.8	0.9
Prostate Cancer	0.2	0.3	0.9	0.7	0.3	-0.1	-0.2	0.8	0.3	0.1	-1.0	-0.3	-0.6	-0.6
Age at First Birth	0.3	0.4	2.4	0.2	0.3	0.1	-0.4	0.3	0.7	-0.2	0.7	1.5	0.6	0.4
Bipolar Disorder (2011)	0.4	0.4	4.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-2.1	-0.2
Body Mass Index (BMI) (2010)	2.7	3.7	8.0	2.5	1.9	-1.6	0.3	2.2	2.4	1.7	1.8	2.8	-0.2	1.8
Coronary Artery Disease (CAD)	1.2	1.5	5.3	1.9	-0.0	-2.3	-0.8	0.3	-1.0	2.0	-0.7	0.7	0.0	-0.8
Crohns Disease (2012)	1.3	2.1	9.2	0.3	-0.4	-2.1	0.5	-2.0	-3.0	1.8	-1.0	-0.1	0.9	0.1
Mean Putamen Volume	0.8	0.9	4.6	-1.3	-0.3	-0.5	1.2	-0.6	0.3	-0.4	-0.5	-0.8	-2.2	-0.1
Fasting Glucose	0.5	0.6	2.6	-0.1	-0.0	0.7	-0.6	1.0	-1.6	-0.1	-0.3	0.3	0.7	-1.3
HbA1C	1.7	1.9	3.9	-1.8	-1.6	-0.1	0.3	-0.8	-2.0	-1.8	-1.5	-1.1	-1.2	-1.4
HDL Cholesterol	0.5	0.8	2.8	1.2	0.9	0.3	0.7	-0.7	0.4	1.0	0.2	0.5	-1.7	-1.2
LDL Cholesterol	0.9	1.4	3.7	-1.9	-1.7	1.3	-1.2	-0.3	-1.2	-0.2	-0.5	-0.9	-0.2	-1.7
Lupus	0.3	0.5	2.8	0.5	-0.5	1.7	0.4	-1.0	0.6	-0.3	0.2	0.4	-0.6	0.1
Neuroticism (2016)	0.4	0.6	1.2	0.9	0.6	-0.9	0.3	1.1	1.0	0.4	0.7	0.0	-1.0	0.3
Primary Biliary Cirrhosis	0.5	0.8	3.0	-1.1	0.3	1.0	-0.2	-0.6	1.7	0.9	-0.7	1.0	-0.6	-0.3
Rheumatoid Arthritis	0.6	0.9	2.3	-1.3	0.4	-0.4	-1.1	1.2	-0.1	0.3	-0.9	1.5	1.3	0.4
Schizophrenia (2014)	0.3	0.7	2.0	0.7	0.4	1.2	1.1	0.6	0.8	1.4	0.1	0.5	-0.8	0.2
Triglycerides	0.9	1.5	4.7	-1.7	-1.4	-2.2	-0.9	0.3	-1.3	-1.2	-1.1	-0.6	0.7	-0.3
Type 2 Diabetes (T2D) (2012)	1.5	1.7	6.7	-2.6	-1.7	-0.8	-0.5	0.2	-2.2	-1.7	-0.2	-0.4	1.0	-0.1
Ulcerative Colitis	1.4	2.0	8.9	0.7	1.7	2.1	1.4	-0.3	0.8	3.0	0.7	1.1	0.6	0.8
Blood Eosinophil Count	1.0	7.7	13.4	3.3	3.6	-0.2	-2.0	2.6	3.6	3.0	1.7	2.1	2.6	3.7
Blood Platelet Count	0.2	2.7	10.8	-1.1	-2.0	-1.4	3.3	-2.3	-1.1	-1.3	-1.3	-0.9	-0.7	-0.6
Blood Red Count	0.2	2.2	11.9	0.7	0.9	-3.5	-1.8	0.7	0.8	0.2	-0.7	-0.5	1.9	1.3
Blood White Count	0.1	0.8	3.8	0.9	-0.1	-1.4	2.0	-0.4	1.2	0.3	-0.3	-0.2	-0.3	-0.4
Heel T-Score	0.1	0.7	3.6	0.1	-0.2	0.1	-1.0	0.6	-0.1	0.3	-0.2	1.9	0.6	1.3
BMI	0.3	2.0	7.0	0.6	0.6	2.1	2.0	-1.5	0.6	1.2	1.0	2.6	-0.4	0.2
Height	0.1	1.7	6.6	0.8	1.9	-0.8	0.1	2.2	0.6	1.1	0.5	-0.1	-2.6	-0.4
Waist Hip Ratio (WHR)	0.2	0.8	2.8	1.5	-0.5	0.0	-1.7	0.6	-1.0	0.7	0.6	0.1	0.6	0.7
Systolic Blood Pressure	0.8	4.0	16.6	2.4	0.7	-2.1	-4.1	1.7	-1.2	1.4	0.2	1.0	2.4	2.0
Smoking Status	0.2	0.5	1.7	0.9	0.8	-0.9	-0.4	-1.3	-0.1	0.5	1.0	-0.5	0.5	0.2
Allergy or Eczema	0.8	2.0	11.6	-3.4	-0.4	2.1	-0.1	0.8	1.2	-0.6	-1.1	0.5	1.3	0.5
Cardiovascular Disease	0.2	0.8	2.4	0.6	0.1	-1.0	-1.6	0.0	-1.3	0.9	0.7	-0.2	0.9	1.0
Hypothyroidism (self reported)	0.2	0.4	2.6	1.6	-0.3	-0.3	-0.5	-0.3	-0.1	0.5	0.3	-0.4	-0.0	-0.3
Respiratory disease	2.1	4.7	12.6	0.5	2.6	1.9	0.6	3.5	3.1	1.6	2.9	2.3	0.0	1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.9	0.1	-1.4	-0.3	-1.2	-1.0	-1.7	-0.5	0.2	0.2	0.0	-1.4
Lung FEV1/FVC ratio	0.7	3.3	6.2	-2.4	-2.3	1.4	0.5	-1.2	-2.5	-1.7	-2.3	-0.9	-0.9	-2.5
Lung FVC	0.1	0.7	2.5	-1.0	0.7	0.4	0.0	1.1	1.6	0.4	-1.1	-0.1	-0.8	-1.0
Neuroticism	0.5	1.3	3.9	0.9	1.2	-0.3	-0.3	1.5	1.4	1.0	1.1	0.9	-0.5	2.0
Chronotype (morning person)	0.2	0.5	1.8	0.8	0.8	-1.0	-0.2	1.2	-0.3	-0.2	-0.3	0.1	1.3	0.1
Hair Pigment	0.4	10.4	48.2	1.0	3.3	-6.9	5.5	-1.5	2.2	0.2	1.3	-3.5	-1.5	0.4
Tanning	0.1	0.7	2.1	1.1	0.1	0.5	0.2	-1.3	-1.0	-0.6	-0.4	-0.3	1.4	0.6
Hand grip strength (left)	1.5	4.0	9.6	1.6	2.0	0.3	0.5	3.1	3.0	2.6	1.7	2.3	-1.8	0.3
Number of treatments/medications taken	1.2	2.2	5.8	1.7	2.4	1.2	0.2	1.1	0.8	1.7	1.6	0.8	1.7	1.9
Average weekly spirits intake	0.6	0.7	2.8	0.1	0.4	1.0	0.9	-0.8	1.7	0.1	0.7	-0.5	-0.4	1.1
Sensitivity / hurt feelings	0.1	0.2	1.5	1.2	0.6	-0.3	0.4	-0.1	-0.2	-0.0	-0.3	0.3	-0.0	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	0.3	1.2	0.4	-0.5	1.0	0.7	0.2	0.5	-0.6	-0.5	-0.5
Hearing difficulty/problems: Yes	0.5	0.7	4.0	0.0	-0.3	-2.0	0.4	-0.0	0.7	-0.4	-0.2	0.4	-1.6	-0.4
Relative age of first facial hair	1.8	3.8	12.5	0.2	-2.0	-3.5	-0.0	-1.6	-1.1	-1.6	-2.1	-0.9	-2.3	-2.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	-0.4	-0.2	0.6	-0.3	-0.0	-0.6	0.4	0.3	1.1	1.1	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.2	0.9	0.7	-0.4	0.4	0.8	0.3	1.0	1.5	0.2	0.9	1.1
Ever had hysterectomy (womb removed)	0.7	0.7	2.3	0.6	0.8	-0.9	0.2	0.8	0.4	0.6	0.8	1.2	0.9	1.5
Systolic blood pressure, automated reading	0.5	1.5	3.3	1.0	1.4	0.2	-1.8	0.4	-0.1	1.8	0.2	1.4	1.6	1.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.2	0.4	-0.3	-1.1	-1.2	0.8	-0.8	0.1	0.4	-0.2	-0.5	-1.5
Angina	1.6	2.1	8.2	-0.1	-0.9	-0.3	-2.9	-0.5	-1.3	-1.1	1.2	0.2	2.7	1.3
Medication for hormone replacement therapy	0.9	1.0	3.3	1.6	-0.0	-1.4	1.8	-0.6	0.3	-0.5	-0.2	-1.6	-0.3	-0.4
Vitamin and mineral supplements	2.3	3.1	9.8	0.4	-2.2	0.1	-2.2	-1.1	-2.4	-0.5	-1.8	-1.6	1.1	-3.1
Supplements: Zinc	1.6	1.7	5.2	-1.0	0.6	0.1	2.3	-0.6	2.3	0.4	0.7	0.8	-1.9	1.3
Medication: Co-codamol	0.6	0.7	2.9	0.1	-0.8	-1.2	-1.7	0.4	-0.5	-0.6	0.6	0.2	0.8	0.7
Medication: Metformin	0.7	1.0	2.6	1.3	0.2	0.1	-1.5	0.5	-1.6	0.2	1.2	0.8	1.4	0.0
Diabetes (father)	1.0	1.2	2.7	-0.8	-0.6	-1.4	0.2	-1.0	-0.8	-1.1	-1.7	-0.3	-1.1	-1.7
Diabetes (mother)	1.9	2.4	7.2	1.9	2.0	0.9	2.1	1.0	2.7	1.0	1.5	0.5	-1.3	0.1
Severe depression (siblings)	1.1	1.2	6.5	-0.3	0.0	0.2	2.5	-1.0	0.3	-0.4	-1.5	-0.6	-1.7	-0.3
Pack years adult smoking proportion	0.5	0.8	4.3	0.5	0.4	0.5	1.0	-0.4	0.5	0.4	1.2	0.1	0.8	2.1
Impedance of leg (right)	0.7	3.2	8.1	-0.5	-0.8	-0.8	-2.9	-0.3	-2.4	-1.9	-2.0	-2.8	1.9	-0.7
Leg fat-free mass (left)	0.9	4.8	12.4	0.5	1.8	1.2	3.2	0.3	2.8	2.5	1.9	2.9	-3.5	0.2
Trunk fat percentage	0.7	2.7	11.1	-0.1	1.2	3.3	2.5	-1.8	1.3	1.7	0.7	1.0	-0.9	1.0
Hand grip strength (right)	1.1	3.1	8.9	2.0	1.8	-0.1	0.3	3.0	2.0	2.4	1.5	1.5	-1.8	-0.1
Townsend deprivation index at recruitment	1.6	2.2	7.1	-1.2	-1.6	-1.1	0.8	-2.7	-0.7	-2.0	-1.5	-2.0	-0.6	-1.0
Current tobacco smoking	0.9	1.5	4.2	1.7	2.0	0.6	0.5	0.0	0.7	1.6	1.6	0.1	0.9	1.5
Average weekly fortified wine intake	0.6	0.7	3.5	-0.2	-0.9	1.2	-0.5	-1.1	-0.2	-0.4	-0.6	-1.9	0.3	-0.0
Maternal smoking around birth	0.1	0.2	0.9	0.4	-0.2	0.0	-0.2	-0.3	-0.0	-0.5	1.0	0.3	-0.2	0.6
Fed-up feelings	0.4	0.7	2.3	1.1	0.8	-1.0	1.2	0.5	0.6	0.0	-0.0	-0.4	-1.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	5.5	0.0	1.2	0.2	0.2	1.7	2.3	-0.1	0.9	0.6	-1.6	0.6
Relative age voice broke	0.7	1.1	3.6	-1.3	-1.6	-0.1	0.7	-0.5	-0.7	-0.5	-1.4	0.2	-1.2	-1.9
Taking other prescription medications	0.8	1.3	3.8	1.9	1.4	0.8	1.0	0.3	1.5	1.6	1.0	0.1	0.1	1.0
Age when periods started (menarche)	0.2	0.5	2.1	0.2	0.7	-0.9	1.5	0.3	0.0	0.2	0.2	-0.7	-1.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.0	0.5	0.3	0.5	-0.3	1.4	0.9	0.4	0.5	-0.6	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.5	1.1	-0.5	-1.9	-0.8	-0.3	0.8	0.2	-0.7	-0.3	-1.2	-0.4
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.8	0.5	0.7	1.9	-1.2	2.0	1.3	1.5	1.5	0.6	0.1	-0.1
Qualifications: CSEs or equivalent	2.3	3.1	13.1	0.9	1.4	3.6	-0.0	2.1	0.5	1.6	1.3	2.8	-0.1	1.1
Serious illness, injury or assault to yourself	0.5	0.6	2.5	0.3	0.1	0.3	-0.0	0.9	1.6	0.3	0.5	1.5	-0.8	-0.2
High blood pressure	0.5	1.3	6.6	-0.2	0.1	-1.3	-2.6	0.3	-0.6	0.7	0.3	0.4	0.9	1.9
Hayfever, allergic rhinitis or eczema	1.0	2.3	7.6	-2.8	0.1	2.6	-0.2	1.1	1.8	0.3	-0.0	1.2	1.4	1.5
Multivitamins +/- minerals	1.3	1.6	5.4	0.1	1.4	0.6	0.8	0.5	1.9	0.4	1.7	1.7	-0.1	2.3
Stomach or abdominal pain in last month	0.5	0.6	3.3	-1.1	-0.7	0.7	0.8	0.0	-0.5	-0.2	0.4	1.8	-0.2	0.1
Supplements: Glucosamine	1.1	1.4	3.3	-1.7	-1.8	-0.7	-1.1	-1.4	-1.0	-1.4	-1.1	-0.3	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.2	0.4	-0.3	1.1	-1.5	0.2	-1.2	0.4	0.1	0.3	2.3	-0.4
Medication: Atenolol	0.7	0.9	4.8	0.1	-0.8	-0.8	-0.2	-0.4	-2.2	-1.3	0.8	-0.3	1.0	0.2
Medication: Levothyroxine sodium	0.7	1.1	3.7	0.0	0.0	0.6	1.3	-1.9	-0.3	-0.5	-1.3	-1.7	-1.1	-0.8
Sitting height	0.6	4.4	11.2	0.7	2.9	1.1	1.1	2.6	3.3	2.0	1.6	1.4	-3.3	0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.3	-0.5	-0.4	0.2	-0.4	-0.9	0.5	-0.3	-1.0	0.6	-0.5
High blood pressure (mother)	1.1	1.6	6.4	1.2	1.1	-0.2	-0.7	1.9	0.1	1.3	1.1	2.5	0.8	0.3
Body mass index (BMI)	0.9	3.9	10.4	0.2	1.2	3.0	3.2	-1.1	2.0	2.3	1.5	2.5	-1.7	0.5
Impedance of leg (left)	0.5	2.3	7.3	-0.3	-0.3	-0.7	-2.7	-0.1	-1.8	-1.3	-1.7	-2.2	2.0	-0.2
Leg predicted mass (left)	0.9	4.8	13.1	0.5	1.7	1.2	3.2	0.3	2.7	2.4	1.8	2.9	-3.6	0.1
Trunk fat mass	0.9	3.7	9.9	0.2	1.7	3.1	2.9	-1.2	2.0	2.3	1.2	1.7	-1.9	0.8
Waist circumference	0.8	2.8	7.4	0.3	1.3	2.6	1.9	-0.2	1.4	1.9	1.8	2.7	-1.4	0.6
Number of incorrect matches in round	1.2	2.0	5.5	0.9	2.1	-1.6	0.5	1.3	1.5	1.3	1.1	2.3	-1.4	0.3
Past tobacco smoking	1.8	3.4	6.8	0.5	2.2	1.7	2.1	2.6	2.6	1.6	0.8	2.1	-0.2	2.0
Alcohol usually taken with meals	0.5	0.8	4.2	1.0	0.5	0.6	0.7	0.9	1.2	0.3	-0.0	2.0	0.2	0.6
Nervous feelings	0.4	0.7	2.9	-0.3	0.9	0.4	1.7	0.5	0.3	0.1	0.9	-0.3	-0.7	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.7	1.0	1.7	1.2	0.7	1.4	1.7	1.9	0.9	0.4	-0.3	1.1
Hearing difficulty/problems with background noise	1.6	2.6	7.4	1.8	1.8	-0.3	0.3	2.7	1.7	1.8	2.1	1.6	-1.1	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	3.5	-0.7	0.6	-0.8	-0.3	1.5	1.4	-0.2	0.0	0.7	-1.9	-0.6
Had menopause	0.9	1.1	2.3	0.9	1.5	0.8	-0.3	1.2	0.5	1.4	1.3	1.3	0.9	1.0
Had other major operations	0.4	0.5	1.6	-1.0	-1.0	-1.3	-0.7	-0.1	-0.1	-0.6	-0.3	0.5	0.5	0.3
Forced vital capacity (FVC)	0.5	2.0	6.9	0.4	1.3	-0.0	0.5	1.9	1.9	1.4	-0.9	0.5	-2.6	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	0.7	-0.4	-1.1	-1.0	-0.1	0.2	0.3	-0.3	-0.5	-0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	4.6	-0.4	-0.3	-0.2	2.1	-0.2	-0.3	-0.2	0.2	-1.4	-0.7	-0.5
Qualifications: None of the above	0.1	0.3	0.8	0.3	-0.2	-0.3	0.0	-0.9	-0.0	-0.2	0.3	-0.7	0.9	0.8
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.0	0.4	-0.5	0.9	0.9	1.1	-0.2	0.2	0.2	-1.0	0.5
Mouth/teeth dental problems	0.9	1.4	7.4	-1.6	-0.7	-0.7	0.5	-0.4	0.1	-2.7	-1.4	-0.2	-1.3	-0.7
Heart attack	0.6	0.7	5.7	0.3	0.4	0.1	0.1	-0.4	-0.3	0.3	0.9	0.9	-0.3	2.4
Allergy	1.4	3.1	7.6	1.8	-0.8	-2.8	-0.2	-1.8	-2.6	-1.0	-1.0	-2.3	-0.8	-2.3
Pain all over the body in last month	0.2	0.3	0.9	0.8	0.4	-0.0	-0.4	0.2	-0.3	-0.0	0.5	0.1	1.0	-0.7
Diabetes (self-reported)	0.6	0.9	3.2	0.5	0.3	-1.0	-1.8	0.3	-0.9	0.4	1.1	1.3	0.6	-1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.0	-1.8	0.7	2.0	-0.9	1.4	1.3	0.1	0.4	0.4	0.4	0.3
Medication: Ramipril	2.3	2.9	7.7	1.5	2.8	0.7	-0.2	1.4	1.0	1.7	2.1	2.4	0.3	2.4
Medication: Simvastatin	0.7	1.0	3.9	1.0	-0.5	-0.8	-2.0	-0.6	-1.6	0.1	0.3	-0.9	1.4	0.3
Fluid intelligence score	1.8	3.7	9.4	-1.3	-2.0	-1.0	-2.0	-1.9	-2.6	-1.3	-1.7	-3.1	2.4	-0.9
Illnesses of siblings	0.6	0.9	1.8	-0.9	-1.0	1.3	1.2	-0.8	-0.1	-0.2	-0.9	0.6	-1.1	-1.2
Neuroticism score	0.6	1.2	2.7	0.7	1.2	-0.5	0.6	1.6	1.2	1.0	0.6	0.8	-1.6	1.4
Weight	1.1	5.2	10.4	0.7	2.3	2.5	3.2	0.1	2.7	2.9	1.9	2.8	-2.8	0.6
Impedance of arm (right)	0.4	1.8	5.9	-0.4	-0.6	0.7	-1.8	-0.9	-1.1	-1.1	-1.2	-2.4	2.1	0.9
Arm fat percentage (right)	0.9	3.6	13.9	0.1	1.0	3.7	3.0	-1.9	1.5	2.0	1.0	1.4	-1.1	1.0
Trunk fat-free mass	0.8	4.7	11.5	0.9	2.1	0.1	2.1	2.0	2.7	2.5	2.2	2.9	-3.4	0.0
Hip circumference	0.9	4.0	11.9	-0.4	1.3	1.8	3.5	-0.6	2.1	1.6	1.1	2.7	-3.2	-0.3
Time employed in main current job	0.7	0.8	2.6	1.1	1.3	-1.6	1.2	-0.0	0.4	0.3	-0.4	-0.8	-0.7	-0.3
Alcohol intake versus 10 years previously	1.1	1.6	4.3	0.6	1.8	-1.7	0.1	1.4	-0.2	0.7	1.6	0.4	2.1	1.6
Father’s age at death	0.4	0.6	2.1	-0.6	-0.7	0.3	1.0	0.1	-0.9	-0.6	-1.0	0.1	-0.3	-1.4
Worrier / anxious feelings	0.6	1.2	4.8	-0.3	1.0	-1.1	-0.8	2.2	1.1	0.5	0.2	1.2	-1.4	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.1	0.3	1.4	0.1	0.4	0.6	0.8	0.5	0.5	0.7	-1.4	-0.4
Falls in the last year	0.8	1.1	3.7	0.8	1.5	0.2	0.9	-0.6	0.8	0.2	1.2	1.6	0.3	1.9
Hair/balding pattern: Pattern 3	0.6	0.8	3.8	0.4	-0.3	-0.8	1.9	-0.6	-1.5	0.0	-0.7	-0.8	0.5	-0.7
Number of live births	0.5	0.7	1.8	0.7	-0.2	0.9	-0.6	0.9	0.2	1.3	-0.7	1.3	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	7.3	-0.2	0.2	0.4	0.8	1.2	1.0	0.9	-1.5	0.4	-2.7	-2.3
Pulse rate	1.0	1.6	4.6	0.3	-1.2	0.2	-1.3	-1.4	-1.7	-0.5	-0.4	-1.8	2.2	-1.2
Happiness	1.1	1.4	3.8	-1.9	-1.0	0.4	-0.8	-0.7	-0.7	-1.2	-1.2	-1.6	-1.2	-1.3
Noisy workplace	0.8	1.0	4.0	0.5	1.3	0.7	0.2	2.0	0.8	1.0	1.5	0.5	-0.5	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.5	-1.6	-0.4	0.6	0.9	0.3	0.3	-0.7	0.0	0.9	-1.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	5.6	0.2	0.9	1.0	2.1	-0.8	0.7	0.3	-1.4	-0.4	-2.4	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.9	8.2	2.5	-0.0	-0.8	-0.5	-1.1	-1.5	1.0	0.5	-0.2	2.9	0.9
Asthma	0.8	1.6	3.8	-0.4	1.1	1.5	0.5	1.8	2.0	0.4	1.6	1.7	-0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	5.6	1.6	2.3	1.6	2.4	0.2	1.5	1.3	1.0	1.0	0.8	2.1
Medication: Cholesterol lowering	1.1	1.7	5.1	2.3	1.9	-0.1	-0.6	0.5	0.9	1.3	1.8	1.2	0.0	1.4
Depression (self-reported)	1.1	1.3	4.4	1.4	2.1	-0.6	1.2	1.3	1.2	0.4	0.7	-0.1	-1.3	0.1
Medication: Lansoprazole	1.1	1.2	6.9	0.1	0.8	0.1	1.2	0.2	1.6	0.1	1.2	-0.3	0.7	2.6
Prospective memory result	1.0	1.3	2.8	1.0	1.7	-0.9	0.3	0.9	1.2	1.2	0.8	1.6	-0.2	1.6
Lung cancer (father)	2.5	2.9	14.4	0.8	0.6	0.7	-2.4	0.6	-1.3	1.0	1.3	-1.8	3.8	1.5
Illnesses of mother	3.3	4.1	8.6	-2.2	-2.2	0.5	-0.9	-2.3	-1.3	-1.8	-2.2	-2.9	-2.1	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.9	0.0	0.8	0.6	1.0	1.8	1.1	1.7	-1.3	0.5	-2.6	-2.2
Pulse wave Arterial Stiffness index	1.3	1.5	4.7	2.2	0.9	0.7	0.6	1.2	1.0	1.2	1.6	1.5	0.2	1.3
Impedance of arm (left)	0.5	2.5	9.6	-0.7	-0.9	-0.2	-1.3	-1.8	-1.6	-1.7	-2.1	-3.1	1.3	0.1
Arm fat mass (right)	1.0	4.1	10.9	0.5	1.4	3.3	3.3	-1.2	2.0	2.4	1.4	2.1	-1.9	0.9
Trunk predicted mass	0.8	4.7	11.6	0.9	2.1	0.1	2.1	2.0	2.6	2.5	2.2	2.9	-3.4	-0.0
Standing height	0.2	2.4	5.8	1.0	2.4	-0.7	0.4	2.4	1.8	1.5	1.0	1.0	-2.4	0.2
Length of working week for main job	1.0	1.1	4.7	-0.8	-2.2	-0.1	0.2	-2.0	-0.8	-1.3	-0.1	-0.3	-0.2	-0.8
Exposure to tobacco smoke at home	1.1	1.3	2.7	-1.0	-1.3	-1.5	0.9	-0.6	-1.1	-1.6	-1.1	-1.2	-0.9	-0.7
Breastfed as a baby	0.3	0.4	1.1	-0.2	0.5	-0.3	-0.9	1.0	0.5	0.8	0.2	0.4	0.8	0.3
Tense / ‘highly strung’	0.6	1.0	2.6	-0.0	0.7	-1.4	0.2	1.6	0.1	1.6	1.1	0.5	-1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.6	2.1	0.6	-1.2	1.2	0.4	0.2	1.0	0.1	-0.9	-0.3	0.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.9	1.1	0.7	0.5	1.1	-1.5	-0.7	-0.6	-0.3	-1.7	0.5	-0.5
Birth weight of first child	0.2	0.4	1.4	-0.0	-0.1	-0.9	0.6	-0.7	0.4	0.5	0.5	0.4	-1.2	1.0
Peak expiratory flow (PEF)	0.5	1.3	5.3	-0.3	-0.1	-0.2	0.5	0.6	0.5	0.7	-1.8	-0.3	-2.3	-2.0
Pulse wave reflection index	0.6	0.7	2.5	0.4	-0.0	-1.0	1.1	0.3	1.4	-0.2	0.3	0.8	-1.6	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	0.1	0.2	0.2	1.4	-1.0	-0.1	1.0	0.3	-1.0	-0.7	0.6
Loud music exposure frequency	1.3	1.4	3.0	1.7	1.5	0.2	0.2	1.2	1.0	0.8	1.6	-1.5	1.5	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.4	-0.0	-0.0	1.2	0.8	0.3	1.0	-0.4	0.3	0.8	-0.8	-0.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.8	0.4	0.4	0.5	0.7	0.4	1.5	1.7	1.4	0.7	-0.6	0.9
Blood clot in the leg (DVT)	0.4	0.6	1.7	0.1	-1.3	0.0	0.2	-1.2	-0.6	-0.7	-0.7	-0.3	-0.4	-1.1
Medication: Paracetamol	1.3	2.2	5.2	0.9	1.8	2.3	2.0	0.3	2.3	1.6	0.8	0.2	-0.6	1.4
Headache pain in last month	2.7	4.6	10.8	2.6	2.9	1.0	-0.0	2.9	1.6	3.3	2.2	2.2	0.9	1.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.6	-1.9	-1.7	1.0	0.7	-0.1	-0.8	-1.0	-1.5	-1.5	-0.0	-2.1
Glaucoma (self-reported)	0.5	0.6	1.9	0.3	0.5	0.4	-0.6	-0.3	1.3	0.8	-0.4	0.6	0.6	1.4
Gout (self-reported)	0.9	1.3	2.6	0.5	-1.4	-1.5	0.4	-1.6	-1.5	-0.6	-1.4	-1.0	-0.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.4	1.1	-0.4	-0.4	0.2	-1.0	-0.3	0.3	-0.4	-1.2	-0.5	-0.7
Medication: Amlodipine	0.3	0.4	2.0	0.1	-0.1	-0.8	0.3	0.4	0.2	-0.4	0.8	0.9	0.1	1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.6	0.2	0.6	-0.3	0.3	1.9	1.4	0.6	0.5	1.2	-1.1	0.6
Birth weight	0.1	0.3	0.8	0.4	0.5	-0.0	-0.7	0.7	0.1	0.5	0.1	0.9	-0.4	-0.5
Chronic bronchitis/emphysema (mother)	2.8	3.2	6.2	-1.9	-2.5	-2.3	-0.3	-2.0	-1.1	-2.4	-2.1	-1.0	-0.9	-1.7
High blood pressure (siblings)	0.8	1.2	5.2	0.4	-0.4	-2.3	-1.7	0.2	-1.3	0.0	0.1	-1.1	1.4	0.4
Forced vital capacity (FVC), Best measure	0.6	2.2	7.5	0.1	1.2	-0.1	0.5	1.9	1.8	1.7	-1.1	0.1	-2.7	-2.1
Body fat percentage	0.7	3.0	11.5	0.0	1.2	3.4	2.7	-2.0	1.3	1.8	0.7	1.1	-1.0	0.8
Leg fat percentage (right)	0.8	2.9	11.8	0.2	1.5	3.4	2.3	-1.1	1.5	2.1	1.1	1.4	-1.2	0.6
Arm fat-free mass (right)	1.0	5.0	12.0	0.8	2.1	0.7	2.4	1.6	2.4	2.7	2.1	3.5	-3.4	-0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.4	-0.5	-1.2	-0.4	0.6	-0.8	-0.6	-1.1	-0.8	0.6	-0.9	-0.3
Comparative body size at age 10	0.5	1.5	6.8	-0.5	-1.0	-2.1	0.3	-0.3	-0.5	-1.0	-0.7	-0.9	-2.6	-1.1
Number of full brothers	1.0	1.2	6.8	0.3	-0.1	2.6	-1.5	0.7	1.0	1.0	0.7	-0.5	0.9	0.5
Worry too long after embarrassment	0.4	0.6	1.9	-1.0	-0.7	-1.3	0.2	-0.3	-0.1	-1.4	0.6	-0.6	-0.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.6	0.0	0.4	-1.6	1.4	0.4	0.3	0.9	0.6	-1.2	-0.7	-0.1
Wheeze or whistling in the chest in last year	2.8	5.0	13.5	0.1	2.7	1.0	1.3	2.8	3.7	1.7	2.3	2.8	-1.5	2.3
Number of children fathered	0.7	0.8	3.1	1.6	0.7	0.0	-1.7	0.0	-0.4	0.4	-0.1	-1.1	1.1	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	6.3	2.4	0.4	-2.5	-1.4	1.0	-0.5	1.7	-0.2	-1.4	2.1	-0.3
Age at first live birth	0.3	0.5	2.0	-1.0	0.5	-0.1	-0.2	0.6	-0.0	-0.9	0.4	0.5	-1.4	-0.6
Pulse wave peak to peak time	1.1	1.3	5.1	-2.3	-0.8	-0.8	-0.5	-1.0	-0.7	-0.9	-1.6	-1.1	-0.6	-1.1
Health satisfaction	0.2	0.2	1.1	-0.5	0.1	1.0	-0.4	0.1	0.1	-0.0	-0.0	0.9	-0.6	-0.1
Shortness of breath walking on level ground	0.4	0.5	1.7	0.0	0.9	0.3	-0.3	0.5	1.3	0.2	0.7	0.4	-0.3	1.3
Qualifications: College or University degree	0.4	1.4	5.0	-2.2	-1.2	-0.7	-0.8	0.3	-0.0	-1.8	-1.0	-0.9	-0.6	-1.5
Eye problems/disorders: None of the above	0.5	0.6	1.4	1.0	0.9	1.2	0.8	0.4	1.1	0.1	0.9	-0.5	0.2	0.9
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.0	1.4	1.3	1.7	0.8	0.8	1.0	1.4	1.6	-1.3	-0.6	-0.9
Emphysema/chronic bronchitis	1.4	1.6	3.7	-0.0	1.9	0.9	0.5	1.8	1.4	1.2	1.5	1.7	0.1	1.0
Medication for pain relief, constipation, heartburn	1.2	2.1	7.0	-1.6	-1.7	-1.9	-0.7	-0.2	-1.2	-2.7	-0.8	-0.6	-0.7	-1.8
Neck or shoulder pain in last month	0.4	0.6	2.7	1.0	0.6	-0.8	-0.1	0.4	0.8	1.6	-0.5	0.3	-0.0	0.6
Medication: Blood pressure	0.7	1.2	4.7	1.3	0.9	-1.7	-0.3	0.1	0.3	0.6	1.0	0.9	-0.0	2.2
Angina (self-reported)	1.3	1.8	6.9	-0.1	-0.8	-0.4	-2.6	-0.8	-1.2	-1.0	1.1	-0.1	2.4	1.2
Migraine (self-reported)	0.5	0.7	1.6	0.7	1.1	0.2	0.2	0.8	0.9	1.2	-0.2	-0.3	-1.3	-1.0
Medication: Ibuprofen	1.0	1.2	2.8	1.5	1.3	1.5	1.1	0.0	0.6	0.7	0.6	0.7	1.4	1.7
Medication: Allopurinol	0.6	0.9	4.2	0.2	-1.2	-1.0	0.3	-2.0	-1.0	-0.4	-0.7	-0.7	0.7	0.0
Medication: Omeprazole	6.2	7.4	12.6	2.4	3.5	2.3	0.2	3.1	3.1	3.6	2.5	3.3	0.9	2.8
Medication: Seretide 50 evohaler	0.5	0.5	2.0	0.9	0.8	0.4	1.4	0.6	1.2	0.2	0.7	0.0	-0.6	0.2
Mean time to correctly identify matches	0.8	1.6	3.6	-1.9	-1.7	0.9	-1.9	-0.4	-1.3	-1.7	-0.5	0.5	1.3	-0.3
Heart disease (mother)	1.0	1.3	3.0	1.2	0.5	-0.5	1.5	1.1	1.0	0.2	1.5	1.6	-0.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	6.6	0.8	1.1	-0.7	-0.6	2.6	1.1	0.5	1.6	1.5	0.5	0.6
Whole body fat mass	0.9	3.8	10.3	0.4	1.6	3.1	3.2	-1.4	1.8	2.2	1.1	1.9	-2.0	0.7
Leg fat mass (right)	1.0	3.9	8.6	0.4	1.8	2.9	2.9	-0.7	2.2	2.4	1.4	2.1	-2.1	0.6
Arm predicted mass (right)	1.0	5.3	12.0	1.0	2.3	0.6	2.7	1.6	2.5	2.8	2.1	3.2	-3.5	-0.3
Pulse rate, automated reading	0.4	1.3	4.1	1.0	1.5	0.5	0.6	1.3	0.9	2.0	1.2	0.5	1.5	0.6
Alcohol intake frequency.	0.1	0.3	2.0	0.2	0.7	-0.1	1.4	-0.2	0.0	-0.0	0.3	0.8	-0.5	0.1
Comparative height size at age 10	0.1	0.5	2.5	0.0	0.6	-0.2	-0.4	1.6	0.4	0.4	1.2	-0.3	-0.0	0.5
Number of full sisters	0.7	0.8	2.3	0.3	0.2	1.1	1.5	-1.2	-0.1	0.5	-0.6	-1.0	0.3	-1.4
Suffer from ‘nerves’	0.5	0.9	2.1	-0.3	1.0	0.9	0.4	1.2	1.5	0.8	1.2	-0.1	-0.8	1.1
Overall health rating	0.8	1.7	5.4	0.4	1.7	0.6	1.0	0.6	1.7	0.7	1.5	2.3	-0.7	1.5
Chest pain or discomfort	0.2	0.3	1.2	-0.9	-0.3	0.8	-0.1	-0.1	-0.8	-0.2	-0.5	1.1	-0.1	-0.0
Had major operations	0.9	1.0	4.4	2.1	0.5	-1.8	0.6	-0.2	-0.6	0.4	-0.5	0.3	-1.5	0.2
Age at last live birth	0.8	1.1	5.0	-1.6	0.0	-0.5	-0.5	1.0	1.2	-0.8	0.3	1.2	-2.2	0.1
Family relationship satisfaction	0.5	0.6	4.3	-1.0	-0.4	0.3	-0.1	0.0	0.5	-0.1	-1.0	0.0	-2.1	-0.6
Leg pain on walking	0.4	0.5	3.1	0.2	0.4	1.8	-0.9	0.3	-0.7	0.4	0.5	-0.6	0.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	6.7	1.3	0.9	2.6	1.3	0.2	0.8	1.6	0.7	1.5	-1.0	-0.1
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.8	1.5	2.0	0.5	0.8	2.6	1.8	1.9	1.9	1.7	0.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.9	-0.3	-0.3	-0.4	-1.0	-0.2	-1.3	-0.4	0.6	-0.7	2.0	0.3
Medication: Aspirin	1.5	2.0	7.3	-0.5	-1.6	-0.7	-2.7	-0.6	-2.4	0.2	-0.5	-1.1	1.9	0.0
Supplements: Vitamin C	0.9	1.0	3.5	-0.2	1.1	-0.3	1.9	1.4	0.8	1.2	0.5	0.3	-1.1	0.9
Knee pain experienced in last month	0.4	0.6	1.7	-0.1	-0.1	1.3	-0.6	0.8	-0.4	1.0	1.1	-0.2	0.7	1.0
Hypertension (Self-reported)	0.3	1.0	4.5	-0.6	0.0	-1.6	-2.1	-0.2	-0.3	0.4	0.1	0.4	0.0	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.5	-0.6	-0.3	-0.8	-0.3	1.3	0.6	-0.3	1.6	0.5	0.9	1.2
Illnesses of father: Heart disease	0.4	0.6	2.7	-0.2	0.7	-0.7	0.1	0.8	1.2	0.7	0.1	1.6	-0.5	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.1	1.1	0.0	-0.2	1.1	-0.3	0.0	-1.0	0.8	0.5	-0.8	0.4
Smoking status: Previous	3.2	4.8	9.8	-1.4	-3.1	-2.0	-2.3	-2.5	-2.9	-2.5	-1.4	-2.1	0.4	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	0.8	1.7	-1.1	0.5	0.4	0.5	0.8	-0.3	-0.9	-1.6	-1.1
Whole body fat-free mass	0.9	5.4	13.0	0.8	2.2	0.5	2.8	1.5	2.8	2.7	2.2	3.2	-3.6	0.0
Leg fat-free mass (right)	1.0	5.5	12.5	0.5	2.0	1.2	3.3	0.6	3.0	2.6	1.9	3.3	-3.5	0.4
Arm fat percentage (left)	0.9	3.5	11.1	-0.1	0.8	3.3	3.3	-2.4	1.4	1.7	0.6	1.3	-1.7	0.7
Average weekly red wine intake	0.5	0.7	3.6	-0.7	-1.3	1.9	-0.2	0.6	-0.7	-0.4	-0.7	0.3	0.6	-0.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	5.7	0.6	0.6	2.4	-0.5	0.4	-0.7	1.2	0.9	1.5	1.6	1.1
Mood swings	1.1	2.0	5.5	1.6	1.8	-0.2	-0.5	2.3	1.2	2.2	1.3	0.7	-0.7	1.5
Loneliness, isolation	0.9	1.3	3.8	1.6	1.3	-1.4	-0.9	1.9	0.4	0.8	0.7	1.2	-0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.3	0.6	0.8	0.5	-1.0	0.1	0.7	0.3	-0.3	-0.2	0.1
Ever had bowel cancer screening	0.4	0.4	1.2	-0.7	-0.3	0.0	-0.2	0.2	-1.0	-0.3	-1.1	-1.0	-0.4	-0.6
Diabetes diagnosed by doctor	0.5	0.9	2.9	0.7	-0.5	-0.0	-1.7	-0.3	-1.5	0.2	1.0	0.8	1.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.0	-0.4	-0.1	-0.8	0.0	-0.5	-0.2	-0.1	0.4	-0.7	-0.5
Friendships satisfaction	0.9	1.1	4.4	-2.1	0.1	0.6	-0.3	0.6	0.1	0.1	-1.2	-0.2	-2.0	-1.2
Qualifications: nursing, teaching	0.3	0.5	1.4	-0.4	0.3	-1.1	-0.3	-0.1	-0.1	-0.8	1.1	-0.3	1.2	1.0
Commuting to job workplace: Walk	1.1	1.2	2.9	-0.5	-1.5	1.7	-1.5	-1.0	-0.8	-0.1	-0.8	-1.3	0.9	-0.9
Eye problems/disorders: Cataract	0.7	0.8	3.1	-0.6	-0.1	0.6	-0.6	0.7	-1.5	0.8	0.6	0.9	1.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.0	-0.2	-0.0	-0.4	-0.6	0.5	-0.8	0.6	0.0	-1.4	0.7	-0.7
Medication for cholesterol	0.3	0.5	1.8	-1.3	-0.6	-0.0	0.4	-0.3	0.1	-1.0	-0.2	0.3	-1.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	0.2	0.8	-0.7	-0.0	-0.1	0.5	1.1	-0.8	-0.8	-0.9	-0.4
Back pain experienced in last month	0.5	0.7	3.2	-1.8	-0.8	1.1	-0.2	-0.5	-0.5	-0.6	-0.3	-0.5	-0.2	-1.2
Mineral and other dietary supplements	0.7	1.0	3.0	1.6	1.4	0.8	0.6	0.9	0.1	0.8	1.7	0.1	0.9	-0.0
Breast cancer (self-reported)	0.7	0.9	2.7	-1.6	-0.6	1.7	-0.6	-0.2	-0.5	-0.5	0.2	-0.4	0.6	-1.6
Asthma (self-reported)	0.8	1.7	3.8	-0.3	1.3	1.6	0.7	1.6	1.9	0.5	1.7	1.7	-0.6	1.1
Osteoporosis (self-reported)	1.0	1.3	3.5	1.9	0.3	-1.5	-0.4	1.6	0.7	1.8	0.3	-1.1	0.3	0.0
Osteoarthritis (self-reported)	0.8	1.0	3.2	0.5	0.8	0.2	-0.2	0.8	0.6	1.0	1.5	0.7	1.8	1.6
Medication: Aspirin	1.2	1.6	6.6	-0.3	-1.3	-0.8	-2.6	-0.8	-2.1	0.3	-0.5	-0.7	1.5	0.3
Medication: Gliclazide	0.6	0.7	2.8	1.1	0.6	-0.1	-0.9	0.7	0.6	0.1	0.8	1.7	0.3	0.7
Illnesses of father: None of the above (group 1)	1.0	1.2	3.2	1.6	0.9	1.1	-0.1	0.1	0.9	0.4	1.1	-0.9	1.5	1.8
Smoking status: Current	0.9	1.5	4.6	1.6	2.1	0.5	0.3	-0.0	0.9	1.9	1.4	0.4	0.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.8	-0.8	0.2	1.0	0.0	2.2	1.8	1.1	-0.8	-1.0	-1.9	-2.1
Whole body water mass	0.9	5.2	12.7	0.8	2.1	0.6	2.7	1.6	2.7	2.7	2.3	3.1	-3.6	0.1
Leg predicted mass (right)	1.0	5.5	12.3	0.6	2.1	1.2	3.3	0.6	3.0	2.7	1.9	3.2	-3.5	0.5
Arm fat mass (left)	1.1	4.4	13.0	0.5	1.5	3.0	3.6	-1.2	2.0	2.4	1.4	2.1	-2.4	0.8
Number of self-reported non-cancer illnesses	0.9	1.6	4.3	1.6	1.9	0.6	-0.6	0.7	0.3	1.4	1.1	0.0	2.1	1.6
Average weekly champagne plus white wine intake	1.5	2.0	10.3	1.3	-0.8	-1.1	-3.2	1.1	-1.4	0.8	0.4	-0.7	2.0	-0.2
Miserableness	0.7	1.2	3.0	-0.2	1.2	1.1	0.2	1.7	1.4	1.2	-0.1	-0.6	-1.7	-0.2
Guilty feelings	1.1	1.6	6.0	1.0	2.5	-1.1	-0.4	1.9	1.2	1.3	0.6	-0.1	0.0	1.6
Wears glasses or contact lenses	2.6	3.0	5.4	2.3	1.9	1.6	-0.8	2.2	0.7	1.8	1.7	1.7	1.8	1.7
Ever taken oral contraceptive pill	0.4	0.5	1.1	-0.5	0.7	0.1	0.1	0.9	1.0	0.5	-0.5	0.3	-1.0	-1.0
Hearing aid user	1.9	2.1	6.1	-2.0	-1.5	-0.7	1.0	-2.5	-0.8	-2.0	-1.5	-0.3	-1.3	-0.8
Mother’s age at death	0.9	1.1	4.1	-0.9	-1.3	-0.1	-0.5	-0.1	-1.6	-1.1	0.4	-1.0	2.0	-0.0
Financial situation satisfaction	0.4	0.5	1.9	-0.2	1.3	1.4	-0.2	0.4	0.7	-0.6	0.2	-0.5	0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.2	-1.0	-1.2	-0.7	-0.6	-0.8	-0.9	0.2	-0.3	-0.1	0.9
Commuting to job workplace: Public transport	2.7	3.2	7.4	-1.5	-2.0	-0.8	-0.9	-2.3	-2.7	-1.4	-2.2	-1.8	0.9	-1.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	0.1	-0.3	-0.4	-0.9	-0.9	0.2	0.3	-1.0	-0.3	0.4	0.5
Medication: Blood pressure	1.0	1.8	5.5	0.6	0.5	-1.0	-2.2	1.2	-0.5	1.0	1.2	0.9	1.9	2.4
Pain type(s) experienced in last month: Hip pain	2.7	3.4	9.0	-0.8	2.1	1.7	-0.6	2.7	1.3	1.6	1.4	3.0	1.2	2.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.4	-2.1	-1.4	0.4	-0.9	-0.8	-0.4	-0.9	-1.2	-0.5	-0.1	0.2
High cholesterol (Self-reported)	1.1	2.0	9.2	0.0	-0.4	0.4	-3.0	-0.0	-2.6	-1.2	0.5	-1.0	1.8	-0.2
Medication: Bendroflumethiazide	0.9	1.4	4.0	0.4	0.9	0.5	-0.8	2.0	1.1	1.0	0.9	1.6	-0.1	1.9
Medication: Paracetamol	0.8	1.2	3.9	0.8	1.4	2.0	0.7	0.5	1.4	1.4	0.6	-0.2	-0.4	1.1
Medication: Lisinopril	0.7	0.9	1.9	0.5	0.2	-0.6	-1.2	1.4	-0.3	1.0	0.0	1.3	1.4	1.1
Medication: Atorvastatin	0.8	1.0	2.9	0.4	1.7	1.3	-0.4	1.0	0.4	0.3	1.5	1.2	-0.6	1.0
Illnesses of father: High blood pressure	1.1	1.4	4.8	-1.4	-1.0	-2.2	-1.5	-0.7	-0.8	-1.4	-0.8	-0.8	-0.8	-0.1
Alcohol drinker status: Never	0.3	0.3	1.4	0.6	-0.1	0.1	1.2	-0.7	0.3	0.1	-0.0	-0.6	0.8	0.5
Ever smoked	0.6	1.0	3.3	0.5	-0.5	-1.1	-1.4	-1.8	-1.2	-0.6	-0.0	-1.1	0.2	-0.7
Basal metabolic rate	1.0	5.4	12.4	0.9	2.2	1.0	3.1	1.0	2.8	2.8	2.2	3.0	-3.5	0.2
Leg fat percentage (left)	0.9	3.2	10.6	0.4	1.7	3.3	2.5	-1.2	1.7	2.3	1.2	1.6	-1.2	0.6
Arm fat-free mass (left)	1.1	5.5	11.4	1.2	2.4	1.1	2.5	2.1	2.6	3.0	2.6	3.4	-2.8	0.3
Number of operations (self-reported)	0.5	0.7	1.7	-0.8	-0.8	-1.2	-0.7	-0.8	-1.0	-1.1	-1.3	-0.2	0.3	-0.2
Average weekly beer plus cider intake	0.3	0.4	1.7	-0.1	0.5	-0.0	-0.0	0.3	0.5	0.8	1.0	0.8	0.1	1.3
Irritability	0.1	0.2	1.5	0.1	-0.4	-1.2	0.3	-0.0	0.1	0.1	-0.2	0.4	-0.7	0.1
Risk taking	0.2	0.3	1.5	1.2	-0.0	0.1	-0.3	-0.3	0.4	0.3	0.2	0.6	-1.0	-0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	0.9	-0.0	-1.1	-0.7	-0.1	0.4	0.0	-0.0	-1.4	0.9	1.0
Fractured/broken bones in last 5 years	0.6	0.8	2.7	-0.5	-1.5	-1.2	-0.3	-0.7	-0.8	-1.6	0.1	-0.8	0.4	-0.2
Age started oral contraceptive pill	0.5	0.7	4.7	-0.5	0.2	-2.2	0.7	0.5	1.1	-0.4	0.1	-0.0	-0.6	0.5
Diastolic blood pressure, automated reading	0.8	2.4	6.1	1.1	2.0	-0.2	-0.1	0.8	1.9	2.5	0.4	2.3	-0.6	2.0
Ever depressed for a whole week	0.5	0.6	2.1	0.7	0.5	-0.7	1.4	0.6	0.3	0.4	1.4	-0.8	-0.7	-0.3
Unable to work because of sickness or disability	0.2	0.3	1.4	0.3	0.8	0.1	0.4	0.2	0.1	-0.2	1.2	0.3	0.6	0.5
Commuting to job workplace: Cycle	1.2	1.5	6.7	-1.0	-1.5	-1.4	-0.9	-0.4	0.0	-2.6	-0.6	-1.5	-1.0	-0.1
Myopia	0.7	1.0	3.1	0.2	1.4	1.8	0.5	0.4	1.6	1.3	0.2	0.4	0.5	1.0
Vascular/heart problems diagnosed by doctor	0.6	1.7	6.7	-0.0	-0.1	1.3	2.6	-0.1	0.8	-0.7	-0.6	-0.5	-1.5	-2.4
Cholesterol lowering medication	1.4	2.1	7.8	-1.1	-1.3	0.8	-2.0	-1.2	-2.8	-1.5	-0.3	-1.3	1.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	4.2	5.1	8.2	1.8	2.8	2.1	-1.0	2.8	2.6	2.9	2.1	2.3	1.4	2.4
Pain experienced in last month	0.3	0.5	1.5	0.1	-0.5	-1.0	-0.2	-0.8	-0.1	-0.7	-0.9	-1.2	-0.7	0.0
Supplements: Calcium	0.8	0.9	2.4	-0.2	1.0	0.2	1.0	1.2	1.5	0.7	1.4	0.6	-1.0	-0.1
Basal cell carcinoma (self-reported)	2.2	2.6	12.7	0.0	0.5	1.3	0.9	2.1	1.9	0.8	1.3	3.6	-1.1	1.5
Heart attack/myocardial infarction (self-reported)	0.6	0.7	5.9	-0.1	0.3	0.3	0.1	-0.3	-0.4	0.1	1.0	0.9	-0.3	2.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	-0.1	-1.4	-0.2	-0.2	-1.4	-0.9	-0.8	-1.1	-0.7	-0.3	-1.4
Heart disease (siblings)	1.2	1.4	6.2	-0.8	0.1	-0.7	-2.5	1.4	-0.6	-0.2	0.5	-0.6	1.9	1.4
Alcohol drinker status: Previous	0.6	0.6	2.6	-1.5	-0.3	-0.6	0.2	0.7	0.8	-0.5	-0.4	0.5	-1.6	-0.1
Pack years of smoking	0.6	0.8	4.9	0.3	0.4	0.5	0.3	-0.1	0.3	0.4	1.2	0.4	1.3	2.2
Impedance of whole body	0.4	2.2	6.9	-0.6	-0.5	-0.2	-2.0	-0.8	-1.6	-1.5	-2.0	-2.6	1.7	-0.0
Leg fat mass (left)	1.0	4.1	9.3	0.5	1.8	2.8	3.1	-0.9	2.3	2.5	1.4	2.3	-2.2	0.6
Arm predicted mass (left)	1.1	5.7	12.0	1.2	2.4	1.3	2.5	2.1	2.6	3.1	2.5	3.5	-3.0	0.2