Hub : Genes

RSL1D1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0850 0.0310 0.0023 0.045 NA 0.028 NA 0.03 0.00013 NA 0.0022 NA 0.0016
2 YFS Blood 0.0191 0.0092 0.0150 -0.001 0.002 -0.001 0.002 0.00 0.86000 0.056 0.9700 0.06 0.4200

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.2 3.5 6.7 -0.6 2.6
Bipolar Disorder or Schizophrenia 0.9 2.2 2.9 -1.7 1.2
Depressed Affect (Nagel 2018) 2.5 5.2 9.2 3.0 -1.1
Depression (Nagel 2018) 3.5 5.2 7.8 2.8 -1.6
Intelligence (Savage-Jansen 2018) 1.4 4.3 8.6 0.2 2.9
Neuroticism (Nagel 2018) 0.5 1.3 1.7 1.3 -0.9
Schizophrenia (2018) 0.8 1.7 3.1 -1.8 -0.5
Schizophrenia vs Biploar Disorder 0.5 0.7 1.4 0.0 -1.2
Worry (Nagel 2018) 0.3 0.6 0.7 -0.7 -0.8
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.2 -0.6
Alzheimer’s Disease (in father) 0.2 0.3 0.5 0.7 0.1
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 0.3 -0.6
Crohns Disease (2017) 0.7 1.5 2.7 -1.6 0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.3 -1.1 0.4
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.1 0.3
Major Depression (MDD) 0.1 0.2 0.3 0.6 -0.1
Reaction Time 0.6 1.1 1.2 -1.0 1.1
Verbal and Numeric Reasoning (VNR) 1.0 2.3 4.1 0.7 2.0
Breast Cancer 1.7 4.1 5.4 1.7 2.3
Ovarian Cancer 0.1 0.1 0.2 0.4 0.0
Prostate Cancer 1.2 1.7 3.2 -1.8 0.4
Age at First Birth 0.2 0.4 0.6 0.8 -0.3
Bipolar Disorder (2011) 3.5 3.4 3.5 -1.9 1.8
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 -0.1 -0.3
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.3 0.3
Crohns Disease (2012) 1.6 2.6 4.2 -2.0 1.1
Mean Putamen Volume 1.3 1.4 1.7 -1.3 1.1
Fasting Glucose 1.1 1.3 2.6 1.6 0.1
HbA1C 0.6 0.6 1.0 -0.5 1.0
HDL Cholesterol 0.3 0.6 0.9 0.9 0.5
LDL Cholesterol 2.3 3.7 5.1 -1.5 2.3
Lupus 3.1 4.7 6.1 -2.5 1.8
Neuroticism (2016) 0.5 0.7 0.7 -0.8 0.9
Primary Biliary Cirrhosis 3.8 5.4 10.4 -0.6 -3.2
Rheumatoid Arthritis 1.3 1.8 3.7 -0.1 -1.9
Schizophrenia (2014) 0.2 0.5 0.7 -0.8 -0.5
Triglycerides 0.3 0.4 0.8 -0.1 -0.9
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.1 0.2
Ulcerative Colitis 0.0 0.0 0.0 -0.0 -0.0
Blood Eosinophil Count 0.1 0.4 0.5 0.7 -0.6
Blood Platelet Count 1.1 12.4 24.3 4.9 0.7
Blood Red Count 1.1 10.5 15.2 -3.9 -2.4
Blood White Count 0.5 4.0 6.1 1.4 -2.5
Heel T-Score 1.1 9.0 17.0 4.1 1.0
BMI 0.8 4.6 9.2 3.0 -0.1
Height 0.0 0.9 1.7 1.3 -0.3
Waist Hip Ratio (WHR) 0.6 2.8 5.6 -0.2 -2.4
Systolic Blood Pressure 3.3 16.4 27.6 -5.2 2.3
Smoking Status 0.1 0.2 0.3 -0.5 -0.4
Allergy or Eczema 0.8 2.0 3.9 -0.4 -2.0
Cardiovascular Disease 0.3 0.9 1.7 -1.3 0.4
Hypothyroidism (self reported) 0.1 0.3 0.4 0.3 -0.7
Respiratory disease 0.2 0.4 0.8 0.9 -0.2
Type 2 Diabetes (T2D) (2018) 2.0 3.7 4.1 2.0 -1.8
Lung FEV1/FVC ratio 0.1 0.3 0.6 -0.1 -0.8
Lung FVC 0.5 2.8 5.5 -2.4 -0.0
Neuroticism 1.0 2.5 4.3 2.1 -0.8
Chronotype (morning person) 0.3 0.6 1.1 0.3 1.1
Hair Pigment 0.0 0.7 1.5 -1.2 -0.1
Tanning 0.1 1.1 1.5 -0.8 1.2
Hand grip strength (left) 0.1 0.2 0.3 -0.6 -0.3
Number of treatments/medications taken 0.6 1.0 1.2 -1.1 0.9
Average weekly spirits intake 4.0 5.0 7.1 -1.7 -2.7
Sensitivity / hurt feelings 1.1 1.9 3.8 0.1 -2.0
Frequency of depressed mood in last 2 weeks 5.9 8.2 11.5 3.4 -2.2
Hearing difficulty/problems: Yes 0.1 0.2 0.3 -0.6 -0.4
Relative age of first facial hair 0.2 0.5 0.9 -0.2 -0.9
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.8 0.5 -1.4
Ever used hormone-replacement therapy (HRT) 2.3 2.9 3.0 1.6 -1.7
Ever had hysterectomy (womb removed) 0.7 0.8 1.5 0.2 -1.2
Systolic blood pressure, automated reading 2.9 8.6 15.1 -3.9 1.4
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.4 -0.4 -1.5
Angina 0.3 0.4 0.7 -0.8 0.5
Medication for hormone replacement therapy 0.1 0.1 0.2 0.1 -0.4
Vitamin and mineral supplements 0.0 0.0 0.1 -0.1 0.2
Supplements: Zinc 0.2 0.2 0.4 0.6 -0.1
Medication: Co-codamol 0.6 0.7 1.4 -0.1 1.2
Medication: Metformin 4.0 5.7 8.3 1.7 -2.9
Diabetes (father) 0.9 1.2 1.9 0.6 -1.4
Diabetes (mother) 0.4 0.5 0.5 -0.7 -0.7
Severe depression (siblings) 0.4 0.4 0.7 0.9 -0.3
Pack years adult smoking proportion 0.9 1.3 2.5 -0.3 -1.6
Impedance of leg (right) 0.1 0.4 0.7 -0.5 -0.8
Leg fat-free mass (left) 0.4 2.4 4.7 2.2 -0.0
Trunk fat percentage 0.8 3.2 6.3 2.5 0.3
Hand grip strength (right) 0.1 0.3 0.5 -0.2 -0.7
Townsend deprivation index at recruitment 3.0 4.2 7.2 1.1 -2.7
Current tobacco smoking 0.5 0.8 1.7 0.1 1.3
Average weekly fortified wine intake 0.8 0.9 1.8 -0.3 -1.3
Maternal smoking around birth 0.1 0.1 0.2 0.5 0.1
Fed-up feelings 2.8 5.0 8.5 2.9 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 4.9 2.2 -0.8
Relative age voice broke 1.6 2.4 4.0 -0.9 -2.0
Taking other prescription medications 0.5 0.8 1.3 -1.1 0.6
Age when periods started (menarche) 1.2 2.9 4.6 -1.1 2.1
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.1 -1.5 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.8 5.7 2.4 -0.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.3 0.7 1.1
Qualifications: CSEs or equivalent 0.5 0.6 1.2 0.2 -1.1
Serious illness, injury or assault to yourself 2.3 2.8 5.4 0.3 -2.3
High blood pressure 0.9 2.6 5.2 -2.3 0.0
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.6 0.7 -1.6
Multivitamins +/- minerals 0.1 0.1 0.1 -0.2 0.4
Stomach or abdominal pain in last month 1.0 1.3 2.4 0.3 1.6
Supplements: Glucosamine 0.5 0.6 1.2 -0.0 1.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 1.8 0.9 1.3
Medication: Atenolol 0.5 0.6 0.8 -0.9 -0.7
Medication: Levothyroxine sodium 0.1 0.2 0.2 -0.4 0.3
Sitting height 0.1 0.4 0.8 0.9 0.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 0.2 -0.8
High blood pressure (mother) 0.3 0.4 0.7 -0.8 0.2
Body mass index (BMI) 0.6 2.4 4.5 2.1 -0.6
Impedance of leg (left) 0.1 0.5 0.6 -0.8 -0.7
Leg predicted mass (left) 0.4 2.3 4.6 2.1 0.0
Trunk fat mass 0.8 3.3 6.4 2.5 0.4
Waist circumference 0.2 0.8 1.3 1.2 -0.5
Number of incorrect matches in round 0.1 0.2 0.3 -0.3 0.6
Past tobacco smoking 0.6 1.1 1.8 1.4 0.6
Alcohol usually taken with meals 0.0 0.0 0.0 -0.1 0.1
Nervous feelings 1.7 3.2 6.2 -2.5 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.4 1.2 -0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.3 -0.5 0.6
Hair/balding pattern: Pattern 2 0.6 0.7 1.4 -1.2 -0.1
Had menopause 6.1 7.6 8.8 3.0 -2.5
Had other major operations 1.0 1.2 2.4 -0.2 -1.5
Forced vital capacity (FVC) 0.3 1.2 1.9 -0.7 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 2.6 1.6 1.3
Ever unenthusiastic/disinterested for a whole week 2.5 3.1 6.0 2.4 -0.4
Qualifications: None of the above 0.9 1.8 2.5 1.1 -1.6
Financial difficulties in last 2 years 1.7 2.2 3.1 1.8 -1.2
Mouth/teeth dental problems 1.2 1.8 3.4 0.5 1.8
Heart attack 0.3 0.4 0.6 -0.8 -0.4
Allergy 1.1 2.5 3.2 -1.4 1.8
Pain all over the body in last month 0.5 0.5 0.6 0.7 0.7
Diabetes (self-reported) 0.8 1.2 1.6 0.9 -1.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.7 0.8 0.6
Medication: Ramipril 1.0 1.3 1.9 -0.9 1.4
Medication: Simvastatin 1.6 2.4 3.8 -1.9 1.0
Fluid intelligence score 1.5 3.1 6.0 0.6 2.4
Illnesses of siblings 0.2 0.3 0.4 0.3 0.6
Neuroticism score 2.0 4.2 6.3 2.5 -1.5
Weight 0.6 3.1 6.2 2.5 -0.2
Impedance of arm (right) 0.2 0.9 1.7 0.2 1.3
Arm fat percentage (right) 0.7 2.8 5.6 2.4 0.2
Trunk fat-free mass 0.0 0.3 0.5 0.7 0.0
Hip circumference 0.4 1.8 3.1 1.8 0.8
Time employed in main current job 0.4 0.5 1.0 -0.1 1.0
Alcohol intake versus 10 years previously 0.3 0.5 0.8 0.9 -0.3
Father’s age at death 1.2 1.5 2.1 1.4 -1.0
Worrier / anxious feelings 0.1 0.3 0.5 0.7 -0.0
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 3.2 0.8 -1.8
Falls in the last year 2.1 2.8 5.4 -0.5 -2.3
Hair/balding pattern: Pattern 3 0.4 0.5 0.9 1.0 0.3
Number of live births 0.3 0.4 0.7 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.2 -0.6 -1.8
Pulse rate 0.4 0.6 1.0 1.0 -0.5
Happiness 3.0 3.6 5.6 2.4 1.3
Noisy workplace 0.5 0.6 0.8 -0.9 -0.7
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.3 1.5 -0.9
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.7 2.8 -1.6 -1.7
Mouth/teeth dental problems: Dentures 1.2 2.0 2.4 -1.5 -1.3
Asthma 0.2 0.3 0.6 0.3 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 0.9 1.0 0.7
Medication: Cholesterol lowering 0.2 0.3 0.4 0.7 0.3
Depression (self-reported) 0.0 0.0 0.1 0.1 -0.2
Medication: Lansoprazole 0.1 0.1 0.2 0.4 0.2
Prospective memory result 1.2 1.5 3.0 -1.7 0.0
Lung cancer (father) 0.7 0.8 1.4 -1.2 0.4
Illnesses of mother 0.8 0.9 1.4 1.2 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 4.2 -1.2 -2.1
Pulse wave Arterial Stiffness index 1.2 1.4 2.5 0.5 -1.6
Impedance of arm (left) 0.3 1.2 1.5 0.9 1.2
Arm fat mass (right) 0.6 2.4 4.8 2.2 -0.0
Trunk predicted mass 0.1 0.3 0.6 0.8 -0.0
Standing height 0.1 0.5 0.6 0.8 0.7
Length of working week for main job 1.2 1.4 2.7 -0.2 1.6
Exposure to tobacco smoke at home 4.0 4.5 8.3 2.9 -0.9
Breastfed as a baby 1.2 1.4 2.4 0.7 -1.5
Tense / ‘highly strung’ 1.0 1.7 2.7 -0.8 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.5 -0.6
Hair/balding pattern: Pattern 4 1.0 2.4 4.8 2.2 -0.2
Birth weight of first child 0.3 0.5 1.0 1.0 -0.0
Peak expiratory flow (PEF) 1.9 4.4 8.1 0.9 -2.8
Pulse wave reflection index 0.6 0.8 1.4 -0.4 -1.2
Ever highly irritable/argumentative for 2 days 1.5 1.8 2.6 1.0 -1.6
Loud music exposure frequency 0.4 0.4 0.8 0.2 -0.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 0.3 -0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.6 -0.7 -1.3
Blood clot in the leg (DVT) 0.3 0.4 0.5 0.7 -0.5
Medication: Paracetamol 0.3 0.6 0.9 0.9 0.5
Headache pain in last month 1.6 2.7 3.3 1.4 -1.8
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.2 0.3 -0.5
Glaucoma (self-reported) 1.9 2.2 3.9 -2.0 0.8
Gout (self-reported) 0.1 0.1 0.2 -0.2 0.4
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 0.1 -0.3
Medication: Amlodipine 1.0 1.4 2.8 -1.7 -0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 -0.6 -0.0
Birth weight 3.0 6.5 11.3 3.4 -1.3
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.3 -0.1
High blood pressure (siblings) 0.9 1.3 2.5 -0.1 -1.6
Forced vital capacity (FVC), Best measure 0.5 1.8 1.9 -1.4 -1.3
Body fat percentage 0.8 3.3 6.6 2.6 -0.3
Leg fat percentage (right) 0.9 3.2 5.4 2.3 -1.0
Arm fat-free mass (right) 0.2 1.0 1.7 1.3 -0.5
Exposure to tobacco smoke outside home 2.5 3.3 6.6 0.3 -2.6
Comparative body size at age 10 0.3 0.7 1.2 -1.1 -0.4
Number of full brothers 2.1 2.7 5.2 0.3 -2.3
Worry too long after embarrassment 0.7 1.2 2.4 1.6 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.3 0.6 -0.2
Wheeze or whistling in the chest in last year 0.3 0.6 1.0 1.0 -0.5
Number of children fathered 0.2 0.2 0.4 -0.7 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.2 0.5 0.4
Age at first live birth 0.6 1.0 1.1 1.0 1.0
Pulse wave peak to peak time 1.4 1.7 2.9 -0.7 1.7
Health satisfaction 0.3 0.4 0.5 0.4 0.7
Shortness of breath walking on level ground 1.6 1.9 2.2 1.2 -1.5
Qualifications: College or University degree 1.5 4.6 9.1 3.0 0.3
Eye problems/disorders: None of the above 0.2 0.3 0.5 -0.3 0.7
Mouth/teeth dental problems: Loose teeth 0.0 0.1 0.1 0.1 -0.3
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.4 -0.7
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 -0.6 -0.1
Neck or shoulder pain in last month 1.5 2.2 3.6 -0.8 -1.9
Medication: Blood pressure 0.2 0.3 0.6 -0.7 0.2
Angina (self-reported) 0.4 0.6 0.6 -0.8 0.7
Migraine (self-reported) 0.4 0.5 0.6 -0.6 0.8
Medication: Ibuprofen 0.7 0.9 1.6 1.3 0.3
Medication: Allopurinol 0.5 0.7 1.0 0.6 -1.0
Medication: Omeprazole 1.7 2.0 2.4 -1.3 1.5
Medication: Seretide 50 evohaler 1.1 1.3 2.5 1.6 -0.2
Mean time to correctly identify matches 0.2 0.3 0.5 -0.7 0.4
Heart disease (mother) 0.2 0.3 0.5 -0.7 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.5 2.9 3.1 1.7 -1.8
Whole body fat mass 0.7 3.0 6.0 2.4 -0.0
Leg fat mass (right) 0.9 3.5 6.5 2.5 -0.7
Arm predicted mass (right) 0.2 1.1 2.0 1.4 -0.5
Pulse rate, automated reading 0.1 0.4 0.9 -0.9 0.1
Alcohol intake frequency. 0.1 0.2 0.4 -0.2 -0.6
Comparative height size at age 10 0.4 2.3 4.6 2.1 0.2
Number of full sisters 2.2 2.7 5.3 0.2 -2.3
Suffer from ‘nerves’ 0.2 0.3 0.5 -0.7 0.0
Overall health rating 0.3 0.7 0.7 -0.9 -0.9
Chest pain or discomfort 1.1 1.6 2.2 1.5 -1.0
Had major operations 1.4 1.6 1.9 1.1 1.4
Age at last live birth 0.6 0.9 1.8 1.3 -0.1
Family relationship satisfaction 0.5 0.7 0.9 -1.0 0.7
Leg pain on walking 1.8 2.3 4.5 -0.2 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.1 -1.4 0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.5 0.7 -0.7
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.8 0.0 2.0
Medication: Aspirin 0.6 0.8 1.5 -0.4 -1.2
Supplements: Vitamin C 0.0 0.1 0.1 -0.0 -0.3
Knee pain experienced in last month 1.1 1.7 2.6 -1.6 0.9
Hypertension (Self-reported) 0.7 2.0 4.0 -2.0 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.2 -0.3
Illnesses of father: Heart disease 0.0 0.0 0.1 -0.2 0.0
Illnesses of siblings: Diabetes 0.8 1.0 1.1 -1.0 1.1
Smoking status: Previous 1.0 1.5 1.8 -1.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 3.2 1.8 -1.0
Whole body fat-free mass 0.1 0.8 1.6 1.3 -0.0
Leg fat-free mass (right) 0.3 1.8 3.5 1.9 0.1
Arm fat percentage (left) 0.9 3.4 6.8 2.6 0.2
Average weekly red wine intake 0.1 0.1 0.2 0.5 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.6 0.3
Mood swings 1.1 1.9 3.8 1.9 -0.3
Loneliness, isolation 2.5 3.5 5.5 2.4 -1.2
Long-standing illness, disability or infirmity 0.4 0.6 1.2 -1.1 -0.2
Ever had bowel cancer screening 1.4 1.7 2.4 -1.5 1.0
Diabetes diagnosed by doctor 0.8 1.3 1.9 0.9 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.4 -0.4
Friendships satisfaction 1.7 2.1 4.1 0.3 2.0
Qualifications: nursing, teaching 0.2 0.3 0.4 0.7 0.3
Commuting to job workplace: Walk 0.1 0.1 0.1 0.0 0.3
Eye problems/disorders: Cataract 1.7 2.0 2.2 1.3 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.0 -0.5
Medication for cholesterol 2.9 4.4 8.3 2.9 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.0 0.3 1.0
Back pain experienced in last month 0.8 1.1 1.7 -1.3 -0.7
Mineral and other dietary supplements 0.5 0.7 0.7 0.8 -0.8
Breast cancer (self-reported) 0.1 0.1 0.2 -0.4 -0.4
Asthma (self-reported) 0.1 0.2 0.2 0.3 -0.5
Osteoporosis (self-reported) 0.3 0.4 0.7 0.2 0.9
Osteoarthritis (self-reported) 1.3 1.7 1.9 -1.2 1.4
Medication: Aspirin 0.6 0.8 1.5 -0.5 -1.2
Medication: Gliclazide 0.2 0.3 0.5 0.2 -0.7
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 -0.9 0.2
Smoking status: Current 0.6 1.0 2.0 -0.0 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 4.1 -1.7 -2.0
Whole body water mass 0.2 0.9 1.7 1.3 -0.1
Leg predicted mass (right) 0.3 1.8 3.5 1.9 0.1
Arm fat mass (left) 0.8 3.2 6.5 2.5 -0.1
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 0.1 0.1
Average weekly champagne plus white wine intake 0.7 0.9 1.9 -1.4 -0.1
Miserableness 0.3 0.6 1.1 1.1 0.1
Guilty feelings 2.0 3.0 4.0 2.0 -1.4
Wears glasses or contact lenses 2.0 2.3 3.4 1.8 -1.1
Ever taken oral contraceptive pill 2.7 3.0 3.3 1.8 -1.7
Hearing aid user 1.2 1.3 2.5 -1.6 -0.4
Mother’s age at death 0.9 1.2 2.3 0.2 1.5
Financial situation satisfaction 2.6 3.2 6.2 2.5 -0.5
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.9 0.5 -1.4
Commuting to job workplace: Public transport 1.0 1.2 2.4 1.5 0.3
Eye problems/disorders: Glaucoma 3.0 3.5 5.5 -2.3 1.3
Medication: Blood pressure 2.9 5.6 11.1 -3.3 -0.2
Pain type(s) experienced in last month: Hip pain 1.8 2.2 3.3 -1.8 1.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.6 -0.4 0.7
High cholesterol (Self-reported) 2.6 4.7 8.7 -0.8 2.9
Medication: Bendroflumethiazide 0.6 0.9 1.4 -1.2 -0.6
Medication: Paracetamol 0.6 0.9 1.2 0.7 1.1
Medication: Lisinopril 0.7 0.9 1.4 -1.2 0.5
Medication: Atorvastatin 2.0 2.5 5.0 2.2 -0.2
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.1 0.5
Alcohol drinker status: Never 0.4 0.5 0.8 -0.5 0.9
Ever smoked 0.5 0.9 1.7 -1.3 0.1
Basal metabolic rate 0.3 1.4 2.9 1.7 -0.0
Leg fat percentage (left) 0.6 2.1 3.8 1.9 -0.7
Arm fat-free mass (left) 0.1 0.5 1.0 1.0 -0.4
Number of operations (self-reported) 0.2 0.3 0.3 0.5 0.6
Average weekly beer plus cider intake 0.6 0.9 1.0 -1.0 1.0
Irritability 1.1 1.8 3.6 1.9 -0.2
Risk taking 0.2 0.3 0.3 -0.5 0.6
Ever had prostate specific antigen (PSA) test 1.8 2.1 4.2 -0.0 2.1
Fractured/broken bones in last 5 years 2.4 3.1 5.2 2.3 -1.0
Age started oral contraceptive pill 0.2 0.3 0.4 -0.5 0.6
Diastolic blood pressure, automated reading 1.6 4.9 9.6 -3.1 0.5
Ever depressed for a whole week 0.6 0.8 1.2 0.6 1.1
Unable to work because of sickness or disability 0.9 1.1 2.2 1.5 0.2
Commuting to job workplace: Cycle 0.5 0.6 1.1 0.3 1.1
Myopia 0.2 0.3 0.5 0.7 -0.0
Vascular/heart problems diagnosed by doctor 1.1 3.0 6.0 2.5 0.2
Cholesterol lowering medication 3.1 4.6 5.2 -2.0 2.3
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 1.6 -0.9 1.3
Pain experienced in last month 2.4 4.0 5.6 2.4 -1.5
Supplements: Calcium 0.1 0.1 0.2 -0.4 -0.0
Basal cell carcinoma (self-reported) 0.2 0.3 0.6 -0.1 0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 -0.7 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.8 0.9 -0.4
Heart disease (siblings) 0.0 0.0 0.1 0.2 0.2
Alcohol drinker status: Previous 0.6 0.7 1.1 -0.5 -1.0
Pack years of smoking 0.9 1.3 2.4 -0.4 -1.6
Impedance of whole body 0.0 0.1 0.1 0.4 0.2
Leg fat mass (left) 0.7 2.7 5.2 2.3 -0.4
Arm predicted mass (left) 0.1 0.6 1.0 1.0 -0.4