Hub : Genes

RSPH9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.220	0.0780	4.3e-03	-0.003	NA	0.001	NA	0.002	6.5e-01	NA	0.26000	NA	0.21000
2	GTEx	Artery Tibial	0.237	0.0746	4.4e-03	-0.002	NA	-0.004	NA	-0.003	5.8e-01	NA	0.93000	NA	0.76000
3	GTEx	Breast Mammary Tissue	0.347	0.1060	9.7e-03	0.084	NA	0.020	NA	0.037	4.3e-05	NA	0.03200	NA	0.00550
4	GTEx	Breast Mammary Tissue (Male)	0.489	0.1508	2.7e-02	-0.010	NA	-0.001	NA	-0.012	6.1e-01	NA	0.35000	NA	0.83000
5	GTEx	Esophagus Gastroesophageal Junction	0.589	0.0880	2.1e-05	0.082	NA	0.078	NA	0.091	6.5e-04	NA	0.00089	NA	0.00036
6	GTEx	Nerve Tibial	0.227	0.0710	1.5e-03	0.002	NA	0.006	NA	0.008	2.4e-01	NA	0.11000	NA	0.08000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	0.9	2.2	-1.2	0.0	-1.1	0.3	-1.5	0.4
Bipolar Disorder or Schizophrenia	0.8	1.9	5.0	-1.7	1.1	-2.2	0.6	0.7	-1.2
Depressed Affect (Nagel 2018)	1.0	2.2	8.3	0.4	-0.8	-0.2	2.9	0.9	-1.8
Depression (Nagel 2018)	0.5	0.7	2.5	0.8	0.1	-0.1	-0.0	1.6	-1.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	7.8	2.8	-2.1	0.2	-0.2	-0.8	0.2
Neuroticism (Nagel 2018)	0.6	1.5	4.8	-0.4	-0.4	0.5	2.2	1.0	-1.6
Schizophrenia (2018)	1.1	2.2	5.3	-1.3	1.3	-2.0	0.4	0.8	-2.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	0.2	0.0	-0.6	0.5	0.6	-1.3
Worry (Nagel 2018)	0.8	1.7	4.0	-0.8	1.1	2.0	1.2	1.7	0.1
Alzheimer’s Disease (in mother)	1.8	2.1	6.0	1.0	-1.2	-2.5	-0.9	-1.4	-1.1
Alzheimer’s Disease (in father)	2.6	2.8	6.9	-1.2	1.9	0.1	0.8	2.6	2.1
Alzheimer’s Disease (including proxy)	0.4	0.5	2.5	0.2	0.1	-1.6	-0.8	0.3	0.1
Crohns Disease (2017)	1.7	3.7	6.6	1.2	-2.0	-2.2	-0.4	-2.3	-2.6
Irritable Bowel Disease (IBD)	1.0	2.4	6.3	-0.7	-0.9	-2.5	-0.5	-1.6	-2.0
Ulcerative Colitis (UC)	0.8	1.5	4.2	-1.4	0.2	-2.1	-0.4	-0.7	-1.3
Major Depression (MDD)	1.1	1.4	6.0	-0.2	0.3	0.1	2.5	0.7	1.2
Reaction Time	0.4	0.8	1.3	-1.0	0.7	1.1	0.8	0.2	1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.3	5.3	2.3	-0.6	0.7	-1.2	-0.5	0.2
Breast Cancer	0.7	1.8	6.2	1.6	0.1	1.2	-0.3	-0.3	2.5
Ovarian Cancer	0.5	0.6	1.5	1.2	-0.6	0.4	-0.3	-1.1	-0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	2.5	0.7	-0.2	1.0	-0.2	0.5	1.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	2.3	0.4	-0.5	0.2	1.5	0.1	0.1
Coronary Artery Disease (CAD)	0.2	0.2	1.0	0.3	0.0	0.2	-1.0	0.0	-0.2
Crohns Disease (2012)	0.3	0.5	1.4	0.2	-1.0	-1.2	0.2	-0.6	-0.5
Mean Putamen Volume	0.4	0.4	1.7	0.2	-0.3	0.3	0.1	-0.8	-1.3
Fasting Glucose	1.3	1.5	3.5	-0.4	-1.2	1.9	0.8	-1.5	-1.2
HbA1C	1.9	2.2	6.9	-0.6	1.3	2.6	-1.1	1.0	1.4
HDL Cholesterol	0.3	0.5	2.0	0.2	0.0	0.8	-0.6	-0.2	1.4
LDL Cholesterol	0.5	0.8	2.5	-1.6	0.0	1.2	1.0	-0.1	-0.0
Lupus	0.9	1.4	4.2	-1.6	-0.5	2.1	0.8	-0.6	0.7
Neuroticism (2016)	0.3	0.4	1.4	-0.6	-0.8	0.1	-1.2	-0.0	-0.5
Primary Biliary Cirrhosis	0.7	1.0	3.6	-0.4	1.3	-1.9	0.6	0.7	0.0
Rheumatoid Arthritis	0.2	0.3	0.7	0.8	0.3	-0.6	0.7	0.4	0.2
Schizophrenia (2014)	0.9	2.0	5.2	-1.4	0.9	-2.3	0.5	0.0	-1.9
Triglycerides	0.6	0.9	2.7	-0.1	0.0	-1.2	1.7	1.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.9	3.6	-1.9	0.0	1.0	-0.7	-0.2	-0.3
Ulcerative Colitis	0.8	1.1	3.6	-1.9	0.2	-1.7	0.1	-0.6	-0.1
Blood Eosinophil Count	0.1	0.8	2.9	1.1	-0.4	0.5	-0.2	-1.7	0.1
Blood Platelet Count	0.4	5.0	20.2	4.5	1.5	-0.4	-2.4	0.2	-1.3
Blood Red Count	1.5	14.5	48.2	-6.9	-0.9	-4.6	2.9	1.7	-2.4
Blood White Count	0.5	4.0	11.8	3.4	-0.6	-0.1	0.8	-0.0	-3.3
Heel T-Score	0.4	3.3	8.7	-1.4	-0.6	-0.9	3.0	1.6	-2.4
BMI	0.4	2.4	6.4	0.6	2.0	1.6	0.8	2.5	0.6
Height	0.4	7.0	12.7	-1.4	-1.2	-3.2	2.5	-3.6	-3.0
Waist Hip Ratio (WHR)	0.8	3.5	15.1	-1.6	0.1	-1.2	0.4	1.4	-3.9
Systolic Blood Pressure	0.7	3.5	9.0	-1.6	1.5	0.7	2.1	3.0	-1.5
Smoking Status	0.5	1.1	3.4	-1.1	0.3	1.4	1.8	0.5	-0.2
Allergy or Eczema	0.2	0.6	1.4	0.9	0.4	-0.9	0.4	-0.2	-1.2
Cardiovascular Disease	0.8	2.7	10.4	0.1	0.3	2.4	0.6	3.2	-0.2
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.6	0.1	0.4	0.7	-0.3	0.7
Respiratory disease	0.5	1.1	2.7	-0.7	1.4	0.7	1.7	0.7	0.0
Type 2 Diabetes (T2D) (2018)	2.4	4.4	16.9	1.6	2.5	-0.1	-0.8	4.1	0.5
Lung FEV1/FVC ratio	0.4	1.8	4.4	1.9	0.2	-1.4	-0.8	2.1	0.5
Lung FVC	0.4	2.1	7.0	-1.1	2.6	-2.0	0.2	0.1	0.2
Neuroticism	0.8	2.0	5.0	-1.4	0.6	0.7	2.2	1.6	-1.1
Chronotype (morning person)	0.3	0.8	1.7	-0.7	0.9	1.3	-0.8	0.3	0.9
Hair Pigment	0.1	2.5	7.3	-2.7	-1.6	-0.4	0.2	-1.9	1.2
Tanning	0.1	0.9	1.6	-0.5	-1.0	-1.3	-1.1	-0.6	0.9
Hand grip strength (left)	0.0	0.1	0.3	-0.5	-0.0	-0.1	-0.0	-0.3	-0.5
Number of treatments/medications taken	0.9	1.6	3.6	1.1	0.8	0.1	1.9	1.8	-0.9
Average weekly spirits intake	0.7	0.8	2.2	-0.3	-0.5	-1.3	1.0	0.0	-1.5
Sensitivity / hurt feelings	1.2	2.0	5.5	-2.4	-2.0	-0.7	1.1	-0.6	-0.3
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.9	0.4	0.0	-1.3	0.8	1.0	-1.4
Hearing difficulty/problems: Yes	1.4	2.1	8.4	1.6	-0.4	-2.9	-0.3	-1.1	0.3
Relative age of first facial hair	0.5	1.1	2.8	-1.6	0.4	-0.7	1.7	0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	5.9	-0.0	0.6	-0.6	0.6	2.4	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	-1.1	-0.1	-0.5	-0.9	-0.0	-0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	-1.3	-1.1	0.4	-0.8	-0.8	-0.2
Systolic blood pressure, automated reading	0.3	1.0	2.8	-0.9	0.6	-0.5	1.7	1.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.5	-1.9	0.3	-0.3	1.0	0.1	-0.8
Angina	1.1	1.4	5.6	2.4	0.6	0.7	0.2	1.0	-0.9
Medication for hormone replacement therapy	0.6	0.7	1.3	0.8	-1.0	-0.7	-0.7	-0.0	1.1
Vitamin and mineral supplements	0.4	0.5	1.9	0.4	0.2	1.4	-0.5	0.3	-0.9
Supplements: Zinc	0.7	0.8	1.7	1.1	0.0	-1.2	0.4	-0.4	-1.3
Medication: Co-codamol	1.1	1.2	3.0	0.6	0.7	-1.0	-1.7	0.6	-1.5
Medication: Metformin	1.1	1.6	3.9	1.2	1.8	0.4	-0.5	2.0	0.7
Diabetes (father)	0.4	0.5	1.6	0.6	0.2	0.3	-1.2	0.5	0.7
Diabetes (mother)	2.1	2.6	6.7	1.2	1.8	-0.1	2.0	2.6	-0.1
Severe depression (siblings)	0.2	0.3	0.6	-0.2	-0.5	-0.4	0.1	0.7	-0.7
Pack years adult smoking proportion	0.7	1.1	1.6	1.3	0.7	1.1	1.1	1.3	-0.8
Impedance of leg (right)	0.7	3.2	8.8	2.3	-3.0	-0.1	-0.5	-2.3	0.3
Leg fat-free mass (left)	0.1	0.7	1.9	-1.2	0.7	-0.2	1.4	-0.0	-0.7
Trunk fat percentage	0.5	1.8	5.4	2.3	-0.9	0.1	2.0	0.0	-0.7
Hand grip strength (right)	0.1	0.3	0.8	0.7	0.1	-0.9	0.2	-0.2	-0.6
Townsend deprivation index at recruitment	0.6	0.9	1.9	-0.4	0.6	-1.2	-0.4	1.4	1.2
Current tobacco smoking	1.3	2.1	4.9	-0.5	1.4	1.2	2.2	2.1	0.3
Average weekly fortified wine intake	0.4	0.5	1.7	0.2	1.3	-0.1	-0.1	1.1	-0.2
Maternal smoking around birth	0.6	0.9	1.7	0.9	-0.1	-0.8	1.3	0.9	-1.3
Fed-up feelings	1.1	2.1	3.9	-1.4	0.2	-1.7	2.0	1.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.7	0.4	-0.8	-0.7	-0.1	-0.4	-1.3
Relative age voice broke	0.4	0.6	1.7	-1.3	0.1	-0.3	1.1	0.8	-0.2
Taking other prescription medications	0.5	0.8	1.7	0.4	0.4	0.2	0.9	1.3	-1.3
Age when periods started (menarche)	0.7	1.6	5.9	-1.1	-0.5	-1.3	-0.0	-0.8	2.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.2	0.5	0.1	-0.2	-0.4	1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.2	3.7	0.3	-0.2	-0.2	1.9	0.4	-1.9
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	5.6	0.9	1.2	-2.0	1.5	2.4	-0.8
Qualifications: CSEs or equivalent	0.5	0.7	2.4	0.7	0.2	-0.2	-0.3	1.0	1.6
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.1	0.7	-0.4	0.8	0.9	-0.4
High blood pressure	0.8	2.1	6.0	1.6	0.6	1.4	1.2	2.4	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.8	0.5	-1.3	-0.1	0.1	-0.7
Multivitamins +/- minerals	0.3	0.4	1.6	0.5	-0.1	-0.7	-0.3	-0.5	1.3
Stomach or abdominal pain in last month	1.0	1.2	3.1	0.8	1.2	-0.8	0.6	1.8	-1.0
Supplements: Glucosamine	0.8	1.0	5.8	0.4	0.3	-2.4	-0.1	-0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.6	-0.0	0.3	0.2	0.3	-0.1
Medication: Atenolol	0.8	1.0	2.7	1.5	1.1	-0.1	0.3	1.6	0.2
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.4	0.2	-0.4	0.3	0.0	0.1
Sitting height	0.3	2.2	4.2	-0.8	-1.6	-1.3	0.7	-2.0	-1.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	-0.8	1.2	0.3	-0.0	0.8	1.3
High blood pressure (mother)	0.5	0.7	1.8	-1.2	0.3	-0.4	0.1	0.8	-1.3
Body mass index (BMI)	0.3	1.4	3.1	1.8	0.7	0.2	1.6	1.4	-0.6
Impedance of leg (left)	0.6	2.7	7.5	2.1	-2.7	0.3	-0.5	-2.0	0.3
Leg predicted mass (left)	0.1	0.7	1.9	-1.1	0.7	-0.2	1.4	0.0	-0.6
Trunk fat mass	0.4	1.6	4.6	2.0	-0.6	-0.2	2.1	0.0	-0.8
Waist circumference	0.4	1.4	2.5	1.6	0.5	0.4	1.3	1.3	-1.4
Number of incorrect matches in round	1.2	2.0	4.7	-2.2	-0.7	-0.6	2.0	-1.0	-1.1
Past tobacco smoking	0.6	1.0	3.5	1.5	0.4	-0.3	-1.9	0.4	-0.1
Alcohol usually taken with meals	1.0	1.6	4.5	2.1	-1.3	-0.0	-0.7	-1.6	0.5
Nervous feelings	0.8	1.5	4.8	-2.2	1.2	0.7	1.0	0.7	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.3	-0.6	-0.7	0.4	0.2	-0.5
Hearing difficulty/problems with background noise	1.4	2.2	7.5	1.9	-0.5	-2.7	-0.5	-1.0	0.9
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	0.2	-0.1	1.3	0.7	-0.5	1.4
Had menopause	0.5	0.7	1.4	-1.2	0.4	0.5	0.3	-1.1	1.0
Had other major operations	1.1	1.4	2.4	0.5	-1.5	-0.2	-1.5	-1.2	1.4
Forced vital capacity (FVC)	0.2	0.9	2.0	-1.4	1.4	-0.0	-0.0	-0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.8	-0.5	-0.2	0.2	1.9	0.4	-1.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	5.8	-1.0	-1.2	-0.3	-0.5	-0.1	-2.4
Qualifications: None of the above	0.4	0.9	2.8	-1.7	0.6	-0.8	0.9	0.8	0.2
Financial difficulties in last 2 years	0.6	0.8	3.0	-0.8	0.7	-0.6	0.1	1.7	0.3
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	0.6	0.5	-0.8	0.0	0.2
Heart attack	0.4	0.5	1.1	0.7	-0.5	1.0	0.8	-0.6	-0.6
Allergy	0.2	0.6	2.2	-0.1	-1.5	0.5	-0.0	-0.5	0.8
Pain all over the body in last month	0.8	0.9	1.8	0.0	-1.2	-1.0	-0.8	0.6	-1.3
Diabetes (self-reported)	1.5	2.3	8.1	1.5	1.7	-0.3	-0.9	2.9	-0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.1	0.1	0.2	-0.3	0.5	0.3	-1.0
Medication: Ramipril	1.6	2.0	5.4	2.3	1.1	-0.9	1.1	1.6	-1.0
Medication: Simvastatin	2.1	3.1	12.6	1.0	0.8	1.6	-0.3	3.5	1.3
Fluid intelligence score	0.9	1.8	5.3	1.8	-0.6	1.1	-2.3	0.4	0.3
Illnesses of siblings	1.4	1.9	7.1	-0.5	-1.8	-0.2	-0.9	-2.7	-0.0
Neuroticism score	1.0	2.0	6.1	-1.9	-0.1	0.4	2.5	1.2	-1.0
Weight	0.2	1.0	3.1	0.8	0.2	-0.4	1.8	0.1	-1.3
Impedance of arm (right)	0.3	1.6	5.3	0.4	-1.9	0.6	0.4	-2.3	0.4
Arm fat percentage (right)	0.5	2.1	6.5	2.3	-0.3	0.3	2.5	0.4	-0.5
Trunk fat-free mass	0.2	1.3	2.3	-1.3	0.3	-1.4	1.3	-0.5	-1.5
Hip circumference	0.3	1.2	4.6	2.1	0.1	0.9	1.1	0.4	0.7
Time employed in main current job	2.1	2.4	4.5	2.1	2.1	1.3	-1.3	1.2	0.7
Alcohol intake versus 10 years previously	0.3	0.4	1.2	0.0	-1.1	0.7	-0.5	-0.2	0.7
Father’s age at death	1.3	1.8	5.2	0.2	-1.1	-0.8	-1.9	-2.3	0.3
Worrier / anxious feelings	1.1	2.1	6.4	-1.4	-0.1	2.5	-0.8	1.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.3	1.2	-0.5	-1.1	1.1	1.5	-0.5
Falls in the last year	0.7	0.9	2.4	1.5	-0.2	0.5	1.0	1.3	-0.3
Hair/balding pattern: Pattern 3	0.8	1.2	3.9	-1.2	-0.3	-2.0	-0.9	-1.1	-0.0
Number of live births	0.8	1.1	3.9	-0.6	-0.2	-2.0	-0.3	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	-0.2	1.1	0.0	-1.3	-0.3	1.4
Pulse rate	1.3	2.2	6.7	-0.8	-0.4	2.2	-0.8	-0.6	2.6
Happiness	1.0	1.3	1.9	-0.4	-1.4	-1.1	1.1	-1.1	-1.3
Noisy workplace	0.8	1.0	3.2	-0.2	0.1	-1.8	0.0	-1.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.6	-0.2	-0.3	1.0	0.0	-0.1	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.2	1.0	-0.2	-0.3	0.1	1.5	-0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	2.9	0.5	-1.7	-0.8	0.9	-1.1	-0.1
Asthma	0.3	0.7	2.2	-1.1	1.5	0.5	0.3	0.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	-0.1	-0.0	0.2	-0.0	-0.2	-0.7
Medication: Cholesterol lowering	1.5	2.3	8.5	2.9	0.5	-0.7	0.1	2.0	-0.7
Depression (self-reported)	0.9	1.1	3.0	-0.8	-1.6	-0.5	-0.1	-0.5	-1.7
Medication: Lansoprazole	0.9	1.0	2.5	0.1	-0.5	-0.8	0.9	1.6	-1.4
Prospective memory result	1.7	2.1	4.6	-2.0	-0.7	1.4	2.1	-1.0	0.8
Lung cancer (father)	0.6	0.8	1.6	0.6	-1.0	0.3	1.2	-1.2	-0.5
Illnesses of mother	0.6	0.7	2.2	0.7	-0.1	1.5	-0.2	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.5	-0.5	0.2	-1.0	-1.2	-1.1	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.5	-0.1	-0.5	0.6	1.2	0.9	-1.0
Impedance of arm (left)	0.2	1.0	2.8	0.3	-1.4	0.8	-0.1	-1.7	0.6
Arm fat mass (right)	0.4	1.6	6.1	1.6	-0.2	0.0	2.5	0.4	-0.8
Trunk predicted mass	0.2	1.4	2.3	-1.3	0.2	-1.4	1.4	-0.6	-1.5
Standing height	0.3	3.1	7.6	-1.8	-0.9	-1.8	1.0	-2.8	-1.8
Length of working week for main job	0.8	0.9	2.0	0.7	-0.9	-0.7	1.4	-1.0	-0.7
Exposure to tobacco smoke at home	1.1	1.2	3.9	1.5	-0.2	2.0	0.6	0.7	-0.0
Breastfed as a baby	1.0	1.3	3.4	0.4	1.8	-0.3	0.9	1.8	-0.2
Tense / ‘highly strung’	1.0	1.6	4.2	-1.3	0.4	0.6	2.0	0.8	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.8	-0.2	0.5	-0.2	1.1	0.9	-1.3
Hair/balding pattern: Pattern 4	0.7	1.6	3.8	-0.5	0.9	-2.0	-0.9	0.9	-1.8
Birth weight of first child	1.1	2.0	5.3	-1.4	-1.5	0.1	1.4	-2.3	-0.7
Peak expiratory flow (PEF)	0.4	1.0	3.6	1.9	0.6	0.1	-0.6	1.1	0.7
Pulse wave reflection index	0.7	0.8	2.1	1.1	0.1	-0.1	1.2	0.4	-1.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.1	0.5	-1.8	-0.5	0.5	-1.0	-1.8
Loud music exposure frequency	0.2	0.2	1.1	-1.1	0.3	-0.1	0.0	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.1	0.9	0.7	1.3	-0.9	-0.3	1.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.7	0.7	-0.2	0.2	0.1	0.8
Blood clot in the leg (DVT)	0.2	0.3	1.1	0.6	0.2	0.1	-0.1	0.0	-1.1
Medication: Paracetamol	0.2	0.3	1.2	0.6	0.2	-1.1	0.3	0.0	0.1
Headache pain in last month	0.4	0.7	1.4	-0.3	1.2	-0.8	0.8	0.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	10.9	-2.1	-1.5	0.3	-0.9	-3.3	0.2
Glaucoma (self-reported)	0.3	0.3	0.8	0.3	0.9	-0.0	0.3	-0.5	-0.8
Gout (self-reported)	1.5	2.1	6.3	-0.7	1.4	0.2	1.1	2.5	-1.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	0.3	0.4	-0.8	0.2	-0.1	-0.3
Medication: Amlodipine	1.8	2.6	6.5	0.2	1.7	2.4	0.7	2.5	-0.3
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.5	-2.1	1.4	-0.0	1.9	0.2	-0.7
Birth weight	0.6	1.3	4.5	-2.1	-0.2	-1.5	0.4	-1.0	0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	-1.0	-1.3	-0.3	0.9	-0.1	-1.1
High blood pressure (siblings)	0.8	1.1	3.3	1.8	0.0	0.7	0.4	1.7	0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	4.0	-1.4	0.1	-0.4	-0.3	-2.0	0.4
Body fat percentage	0.6	2.2	7.8	2.8	-0.9	0.1	2.1	0.2	-0.5
Leg fat percentage (right)	0.9	3.2	14.8	3.9	-0.8	0.2	1.8	0.7	0.1
Arm fat-free mass (right)	0.1	0.7	1.4	-0.8	0.2	-1.2	0.9	-0.2	-1.1
Exposure to tobacco smoke outside home	1.3	1.7	4.7	0.3	-0.1	2.2	-1.2	0.2	2.1
Comparative body size at age 10	0.5	1.5	4.2	-1.4	1.6	0.2	-0.1	2.1	-0.0
Number of full brothers	1.0	1.3	3.2	0.4	0.6	-1.8	1.3	0.9	-1.1
Worry too long after embarrassment	0.5	0.9	2.3	-1.5	0.2	0.5	1.4	0.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	6.4	0.1	0.9	0.1	2.5	1.9	-1.2
Wheeze or whistling in the chest in last year	0.6	1.0	2.4	-0.7	1.6	0.9	0.2	1.0	-1.2
Number of children fathered	0.6	0.6	2.7	-0.1	0.7	0.4	0.3	1.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	4.6	0.3	0.7	1.1	-2.1	0.5	-0.2
Age at first live birth	1.2	2.2	5.4	-0.1	-0.6	2.3	-1.6	-1.8	1.2
Pulse wave peak to peak time	0.5	0.6	1.4	-0.1	0.4	-0.5	-1.0	-1.2	0.8
Health satisfaction	1.0	1.3	2.0	0.2	-1.3	-1.1	-1.1	-1.4	-1.4
Shortness of breath walking on level ground	0.9	1.1	2.7	-0.2	-1.6	-1.0	-1.1	-1.3	-0.1
Qualifications: College or University degree	0.2	0.6	1.7	1.0	-0.3	1.3	0.3	0.1	1.0
Eye problems/disorders: None of the above	1.0	1.1	2.8	0.8	-0.5	0.5	-1.6	-1.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	-0.4	1.2	0.5	0.8	1.1	0.6
Emphysema/chronic bronchitis	0.9	1.0	2.2	-0.7	-1.5	-1.4	0.5	-0.5	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.6	1.4	-0.2	-0.8	0.7	-0.4	-0.8	1.2
Neck or shoulder pain in last month	0.3	0.4	1.4	0.1	0.1	1.2	-0.9	-0.2	-0.3
Medication: Blood pressure	1.3	2.3	6.7	0.8	1.7	0.3	1.8	2.6	-0.5
Angina (self-reported)	0.8	1.1	5.1	2.3	0.3	0.5	0.1	0.7	-0.8
Migraine (self-reported)	1.5	1.9	7.7	-2.8	-0.6	0.6	1.5	-0.2	-0.8
Medication: Ibuprofen	0.3	0.3	1.8	0.3	0.0	0.2	1.3	0.2	-0.2
Medication: Allopurinol	2.6	3.4	9.8	0.5	1.5	-0.8	1.5	3.1	-2.3
Medication: Omeprazole	2.2	2.6	10.3	-0.1	0.0	-3.2	-0.7	0.1	-2.2
Medication: Seretide 50 evohaler	0.9	1.0	2.0	-1.2	1.4	0.9	-0.6	1.0	0.7
Mean time to correctly identify matches	0.2	0.4	1.0	-0.9	0.7	-0.4	1.0	-0.2	0.4
Heart disease (mother)	0.6	0.7	2.8	1.7	-0.7	0.8	-0.6	0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.5	-0.6	0.5	-0.4	-1.2	0.8	0.3
Whole body fat mass	0.4	1.6	4.8	2.0	-0.4	-0.1	2.2	0.3	-0.5
Leg fat mass (right)	0.6	2.1	8.8	3.0	-0.5	0.2	1.9	0.3	-0.1
Arm predicted mass (right)	0.2	0.9	2.0	-0.7	0.4	-1.4	1.0	-0.0	-1.3
Pulse rate, automated reading	0.8	2.6	7.3	-1.4	0.7	2.7	-0.8	0.4	2.3
Alcohol intake frequency.	0.2	0.6	1.9	-0.1	0.7	0.6	0.8	1.4	-0.2
Comparative height size at age 10	0.2	0.9	3.0	-0.6	0.4	0.5	0.4	-1.3	-1.7
Number of full sisters	0.7	0.8	1.7	-1.3	0.6	0.6	1.0	0.8	0.9
Suffer from ‘nerves’	0.7	1.2	2.1	-0.9	1.1	1.4	1.4	0.9	-0.0
Overall health rating	0.7	1.4	5.3	2.3	0.2	0.9	0.6	1.4	-0.6
Chest pain or discomfort	0.5	0.8	1.6	0.8	0.8	-0.3	0.3	1.3	-1.1
Had major operations	1.1	1.3	5.9	2.4	0.1	0.6	0.2	1.3	-0.4
Age at last live birth	1.8	2.6	7.5	-0.2	-1.1	0.4	-2.7	-2.3	1.0
Family relationship satisfaction	0.5	0.6	1.6	0.2	-0.6	-0.5	1.3	0.2	-1.2
Leg pain on walking	0.8	1.0	2.5	0.4	-0.4	-1.6	0.9	-0.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.5	-0.4	-0.6	0.1	-1.0	-0.8
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.5	-0.4	0.7	1.5	-0.6	0.3	1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	-0.3	-0.1	0.2	-0.7	-1.2	0.9
Medication: Aspirin	0.9	1.1	2.7	1.6	0.4	1.2	0.2	1.6	0.1
Supplements: Vitamin C	0.4	0.5	1.7	-1.3	-0.3	0.8	-0.6	-0.5	0.0
Knee pain experienced in last month	0.9	1.5	6.3	-1.3	0.1	-0.4	2.5	0.4	-0.6
Hypertension (Self-reported)	0.7	1.8	5.0	1.1	0.5	1.7	1.1	2.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.0	-0.6	0.8	-1.4	0.5	1.2	-1.4
Illnesses of father: Heart disease	0.5	0.7	1.7	1.3	0.4	0.8	-0.4	1.2	0.3
Illnesses of siblings: Diabetes	2.3	2.8	6.8	-1.0	2.6	-0.4	1.0	2.5	-1.3
Smoking status: Previous	0.7	1.1	2.7	-1.6	-0.8	0.7	1.3	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	9.7	-1.6	-1.5	0.8	-2.2	-3.1	0.3
Whole body fat-free mass	0.2	1.1	2.2	-1.2	0.6	-0.9	1.5	-0.3	-1.2
Leg fat-free mass (right)	0.2	1.0	2.5	-1.6	0.9	-0.0	1.4	0.1	-0.7
Arm fat percentage (left)	0.5	1.8	5.2	2.3	-0.3	0.5	2.2	0.6	-0.3
Average weekly red wine intake	0.9	1.4	4.3	0.1	-1.8	0.0	0.9	-2.1	-0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	5.0	-1.0	-1.1	0.0	-1.3	-2.2	-0.6
Mood swings	1.0	1.8	5.8	-0.9	-1.2	-0.8	1.4	-0.3	-2.4
Loneliness, isolation	0.0	0.1	0.2	0.0	0.2	-0.4	0.3	0.2	-0.2
Long-standing illness, disability or infirmity	0.7	1.0	4.0	0.4	-0.5	-0.7	2.0	0.5	-0.9
Ever had bowel cancer screening	0.8	1.0	4.2	2.0	0.3	0.5	-0.1	0.7	-0.9
Diabetes diagnosed by doctor	1.7	2.8	8.9	1.4	2.0	-0.2	-1.2	3.0	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.3	0.0	0.8	2.1	1.4	1.1	0.2
Friendships satisfaction	1.6	1.9	4.9	-0.3	-1.7	-2.2	1.4	-0.5	-1.2
Qualifications: nursing, teaching	1.1	1.7	3.3	1.8	-0.7	-1.1	1.8	-1.0	-1.0
Commuting to job workplace: Walk	0.6	0.6	1.0	-0.6	-0.9	-0.6	0.5	-1.0	-0.9
Eye problems/disorders: Cataract	1.2	1.4	5.5	-0.5	0.4	0.2	0.2	2.4	1.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.5	0.8	-1.3	-0.2	0.3	-0.6
Medication for cholesterol	1.0	1.4	4.1	-1.0	0.5	-2.0	-0.1	-1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	6.9	-1.1	-2.6	-0.5	-0.7	-1.7	-1.9
Back pain experienced in last month	0.2	0.3	1.1	-0.4	-0.2	1.0	-0.4	0.5	-0.0
Mineral and other dietary supplements	1.0	1.4	4.4	0.2	0.6	1.6	0.2	2.1	-1.1
Breast cancer (self-reported)	0.4	0.5	1.3	0.2	-1.1	0.6	0.3	-1.1	-0.4
Asthma (self-reported)	0.4	0.8	2.7	-1.1	1.6	0.6	0.5	0.5	-0.4
Osteoporosis (self-reported)	2.0	2.5	9.1	-0.7	3.0	-0.6	1.0	2.0	-0.1
Osteoarthritis (self-reported)	1.3	1.7	6.3	0.3	-2.5	0.2	0.0	-1.8	0.6
Medication: Aspirin	1.2	1.5	4.1	1.4	0.6	1.4	0.9	2.0	0.2
Medication: Gliclazide	0.8	0.9	3.2	1.8	0.1	0.2	-1.3	0.7	-0.3
Illnesses of father: None of the above (group 1)	2.2	2.8	5.1	0.7	-0.9	-2.2	1.1	-2.0	-2.3
Smoking status: Current	0.9	1.5	3.2	-0.5	1.1	0.9	1.8	1.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.2	-0.9	0.6	-1.5	-1.2	-0.5	-0.5
Whole body water mass	0.2	1.1	2.0	-1.3	0.5	-1.0	1.4	-0.2	-1.2
Leg predicted mass (right)	0.2	1.0	2.6	-1.6	0.9	-0.0	1.4	0.1	-0.7
Arm fat mass (left)	0.3	1.4	5.0	1.7	-0.2	0.0	2.2	0.6	-0.7
Number of self-reported non-cancer illnesses	1.3	2.3	5.9	-0.8	0.4	0.2	2.1	1.6	-2.4
Average weekly champagne plus white wine intake	1.9	2.6	9.9	1.2	0.4	1.2	-1.3	1.1	3.1
Miserableness	1.6	2.8	8.9	0.9	-0.5	-2.1	3.0	1.2	-1.0
Guilty feelings	1.4	2.0	4.2	-2.0	0.2	-0.8	2.0	0.7	-1.7
Wears glasses or contact lenses	1.0	1.2	4.1	2.0	0.4	0.5	1.4	-0.2	-0.7
Ever taken oral contraceptive pill	1.0	1.2	4.5	0.6	0.2	2.1	-0.1	-0.6	1.3
Hearing aid user	0.5	0.6	1.3	-0.0	0.8	-0.4	-1.1	-1.0	-0.6
Mother’s age at death	1.6	1.9	4.9	0.8	2.2	-1.0	-0.7	1.2	1.8
Financial situation satisfaction	0.4	0.4	1.1	-1.0	-0.9	0.1	-0.5	-0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.5	0.9	0.3	-1.6	0.1	-0.6	0.4
Commuting to job workplace: Public transport	1.0	1.2	6.2	0.7	0.3	0.6	-2.5	0.4	-0.1
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	0.1	1.0	0.5	0.1	-0.3	0.3
Medication: Blood pressure	1.5	2.8	11.7	0.5	0.8	3.4	0.5	2.1	0.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.1	1.0	-0.6	1.6	-2.7	-0.6	0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.0	-0.8	-1.0	-0.6	0.6	-2.2	0.7
High cholesterol (Self-reported)	0.4	0.7	1.8	0.3	-1.4	-0.4	-0.8	0.8	-1.1
Medication: Bendroflumethiazide	1.5	2.2	4.9	-0.0	1.8	2.2	-0.3	2.2	0.4
Medication: Paracetamol	0.2	0.3	1.0	0.3	0.1	-0.2	1.0	-0.1	0.9
Medication: Lisinopril	0.2	0.3	0.8	-0.3	-0.2	0.5	0.9	-0.5	0.5
Medication: Atorvastatin	1.6	1.9	4.9	1.0	0.1	-2.1	0.9	0.6	-2.2
Illnesses of father: High blood pressure	0.5	0.6	1.9	1.0	-0.6	1.4	-0.6	0.3	-0.1
Alcohol drinker status: Never	0.5	0.6	2.7	0.7	0.5	0.5	-0.1	1.6	-0.1
Ever smoked	0.3	0.5	1.4	-0.7	0.2	0.3	1.2	0.1	1.0
Basal metabolic rate	0.2	1.0	2.8	-0.8	0.3	-0.8	1.7	-0.2	-1.3
Leg fat percentage (left)	0.7	2.7	11.7	3.4	-0.5	0.5	1.7	0.9	0.1
Arm fat-free mass (left)	0.2	1.2	2.8	-0.4	0.3	-1.5	1.7	0.0	-1.4
Number of operations (self-reported)	0.7	1.1	2.9	1.7	0.5	-1.0	0.4	1.3	-0.8
Average weekly beer plus cider intake	1.0	1.4	5.2	-2.3	0.2	-0.3	1.3	0.1	-1.2
Irritability	0.5	0.8	1.8	-0.3	0.3	1.0	1.3	1.3	-0.1
Risk taking	2.8	4.0	10.6	-0.3	-3.2	-1.1	0.0	-1.4	-3.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.0	1.3	-0.8	-0.8	1.2	0.5	-1.4
Fractured/broken bones in last 5 years	0.8	1.0	4.6	0.1	-0.2	2.1	1.0	-0.2	0.6
Age started oral contraceptive pill	0.6	0.7	2.2	-0.9	0.6	-0.6	-1.5	-0.6	0.1
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.8	-0.1	0.6	0.9	-0.1	-0.3
Ever depressed for a whole week	0.3	0.4	1.2	-0.5	-0.6	-0.2	0.5	0.5	-1.1
Unable to work because of sickness or disability	0.4	0.5	1.5	0.5	-0.9	0.7	-1.2	0.4	-0.0
Commuting to job workplace: Cycle	0.4	0.5	2.2	-1.5	-0.1	0.2	-0.0	-0.3	-0.8
Myopia	0.9	1.3	3.2	1.3	-0.6	-0.3	1.4	0.7	-1.8
Vascular/heart problems diagnosed by doctor	0.9	2.6	6.1	-2.1	-0.5	-1.5	-1.4	-2.5	0.5
Cholesterol lowering medication	1.0	1.5	5.0	-0.6	-0.6	2.2	0.4	1.8	0.5
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	8.7	0.1	-0.6	-3.0	-1.3	-0.1	-2.4
Pain experienced in last month	0.2	0.4	1.1	-0.1	-0.9	-0.1	0.2	-1.1	0.5
Supplements: Calcium	1.1	1.2	3.8	0.3	-0.5	0.5	-2.0	-1.6	0.3
Basal cell carcinoma (self-reported)	1.3	1.6	3.5	-0.9	-0.6	-0.5	1.7	-1.3	-1.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	0.8	-0.6	0.9	1.0	-0.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.5	0.2	0.2	-0.3	-0.2	-0.9
Heart disease (siblings)	1.3	1.5	4.6	1.4	1.1	-0.7	0.9	2.1	-0.3
Alcohol drinker status: Previous	2.1	2.4	5.0	-0.6	2.2	-1.1	1.6	2.2	-0.7
Pack years of smoking	0.6	0.9	1.4	1.2	0.8	0.9	1.1	1.0	-0.7
Impedance of whole body	0.4	1.8	4.8	1.2	-2.2	0.4	-0.3	-2.0	0.5
Leg fat mass (left)	0.4	1.7	6.5	2.5	-0.2	0.3	1.8	0.6	-0.0
Arm predicted mass (left)	0.3	1.3	2.9	-0.9	0.3	-1.2	1.7	-0.1	-1.6