Hub : Genes

RSPH9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.220 0.0780 4.3e-03 -0.003 NA 0.001 NA 0.002 6.5e-01 NA 0.26000 NA 0.21000
2 GTEx Artery Tibial 0.237 0.0746 4.4e-03 -0.002 NA -0.004 NA -0.003 5.8e-01 NA 0.93000 NA 0.76000
3 GTEx Breast Mammary Tissue 0.347 0.1060 9.7e-03 0.084 NA 0.020 NA 0.037 4.3e-05 NA 0.03200 NA 0.00550
4 GTEx Breast Mammary Tissue (Male) 0.489 0.1508 2.7e-02 -0.010 NA -0.001 NA -0.012 6.1e-01 NA 0.35000 NA 0.83000
5 GTEx Esophagus Gastroesophageal Junction 0.589 0.0880 2.1e-05 0.082 NA 0.078 NA 0.091 6.5e-04 NA 0.00089 NA 0.00036
6 GTEx Nerve Tibial 0.227 0.0710 1.5e-03 0.002 NA 0.006 NA 0.008 2.4e-01 NA 0.11000 NA 0.08000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 0.9 2.2 -1.2 0.0 -1.1 0.3 -1.5 0.4
Bipolar Disorder or Schizophrenia 0.8 1.9 5.0 -1.7 1.1 -2.2 0.6 0.7 -1.2
Depressed Affect (Nagel 2018) 1.0 2.2 8.3 0.4 -0.8 -0.2 2.9 0.9 -1.8
Depression (Nagel 2018) 0.5 0.7 2.5 0.8 0.1 -0.1 -0.0 1.6 -1.0
Intelligence (Savage-Jansen 2018) 0.7 2.2 7.8 2.8 -2.1 0.2 -0.2 -0.8 0.2
Neuroticism (Nagel 2018) 0.6 1.5 4.8 -0.4 -0.4 0.5 2.2 1.0 -1.6
Schizophrenia (2018) 1.1 2.2 5.3 -1.3 1.3 -2.0 0.4 0.8 -2.3
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 0.2 0.0 -0.6 0.5 0.6 -1.3
Worry (Nagel 2018) 0.8 1.7 4.0 -0.8 1.1 2.0 1.2 1.7 0.1
Alzheimer’s Disease (in mother) 1.8 2.1 6.0 1.0 -1.2 -2.5 -0.9 -1.4 -1.1
Alzheimer’s Disease (in father) 2.6 2.8 6.9 -1.2 1.9 0.1 0.8 2.6 2.1
Alzheimer’s Disease (including proxy) 0.4 0.5 2.5 0.2 0.1 -1.6 -0.8 0.3 0.1
Crohns Disease (2017) 1.7 3.7 6.6 1.2 -2.0 -2.2 -0.4 -2.3 -2.6
Irritable Bowel Disease (IBD) 1.0 2.4 6.3 -0.7 -0.9 -2.5 -0.5 -1.6 -2.0
Ulcerative Colitis (UC) 0.8 1.5 4.2 -1.4 0.2 -2.1 -0.4 -0.7 -1.3
Major Depression (MDD) 1.1 1.4 6.0 -0.2 0.3 0.1 2.5 0.7 1.2
Reaction Time 0.4 0.8 1.3 -1.0 0.7 1.1 0.8 0.2 1.1
Verbal and Numeric Reasoning (VNR) 0.6 1.3 5.3 2.3 -0.6 0.7 -1.2 -0.5 0.2
Breast Cancer 0.7 1.8 6.2 1.6 0.1 1.2 -0.3 -0.3 2.5
Ovarian Cancer 0.5 0.6 1.5 1.2 -0.6 0.4 -0.3 -1.1 -0.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.5 0.7 2.5 0.7 -0.2 1.0 -0.2 0.5 1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 2.3 0.4 -0.5 0.2 1.5 0.1 0.1
Coronary Artery Disease (CAD) 0.2 0.2 1.0 0.3 0.0 0.2 -1.0 0.0 -0.2
Crohns Disease (2012) 0.3 0.5 1.4 0.2 -1.0 -1.2 0.2 -0.6 -0.5
Mean Putamen Volume 0.4 0.4 1.7 0.2 -0.3 0.3 0.1 -0.8 -1.3
Fasting Glucose 1.3 1.5 3.5 -0.4 -1.2 1.9 0.8 -1.5 -1.2
HbA1C 1.9 2.2 6.9 -0.6 1.3 2.6 -1.1 1.0 1.4
HDL Cholesterol 0.3 0.5 2.0 0.2 0.0 0.8 -0.6 -0.2 1.4
LDL Cholesterol 0.5 0.8 2.5 -1.6 0.0 1.2 1.0 -0.1 -0.0
Lupus 0.9 1.4 4.2 -1.6 -0.5 2.1 0.8 -0.6 0.7
Neuroticism (2016) 0.3 0.4 1.4 -0.6 -0.8 0.1 -1.2 -0.0 -0.5
Primary Biliary Cirrhosis 0.7 1.0 3.6 -0.4 1.3 -1.9 0.6 0.7 0.0
Rheumatoid Arthritis 0.2 0.3 0.7 0.8 0.3 -0.6 0.7 0.4 0.2
Schizophrenia (2014) 0.9 2.0 5.2 -1.4 0.9 -2.3 0.5 0.0 -1.9
Triglycerides 0.6 0.9 2.7 -0.1 0.0 -1.2 1.7 1.1 -0.4
Type 2 Diabetes (T2D) (2012) 0.7 0.9 3.6 -1.9 0.0 1.0 -0.7 -0.2 -0.3
Ulcerative Colitis 0.8 1.1 3.6 -1.9 0.2 -1.7 0.1 -0.6 -0.1
Blood Eosinophil Count 0.1 0.8 2.9 1.1 -0.4 0.5 -0.2 -1.7 0.1
Blood Platelet Count 0.4 5.0 20.2 4.5 1.5 -0.4 -2.4 0.2 -1.3
Blood Red Count 1.5 14.5 48.2 -6.9 -0.9 -4.6 2.9 1.7 -2.4
Blood White Count 0.5 4.0 11.8 3.4 -0.6 -0.1 0.8 -0.0 -3.3
Heel T-Score 0.4 3.3 8.7 -1.4 -0.6 -0.9 3.0 1.6 -2.4
BMI 0.4 2.4 6.4 0.6 2.0 1.6 0.8 2.5 0.6
Height 0.4 7.0 12.7 -1.4 -1.2 -3.2 2.5 -3.6 -3.0
Waist Hip Ratio (WHR) 0.8 3.5 15.1 -1.6 0.1 -1.2 0.4 1.4 -3.9
Systolic Blood Pressure 0.7 3.5 9.0 -1.6 1.5 0.7 2.1 3.0 -1.5
Smoking Status 0.5 1.1 3.4 -1.1 0.3 1.4 1.8 0.5 -0.2
Allergy or Eczema 0.2 0.6 1.4 0.9 0.4 -0.9 0.4 -0.2 -1.2
Cardiovascular Disease 0.8 2.7 10.4 0.1 0.3 2.4 0.6 3.2 -0.2
Hypothyroidism (self reported) 0.1 0.3 0.5 -0.6 0.1 0.4 0.7 -0.3 0.7
Respiratory disease 0.5 1.1 2.7 -0.7 1.4 0.7 1.7 0.7 0.0
Type 2 Diabetes (T2D) (2018) 2.4 4.4 16.9 1.6 2.5 -0.1 -0.8 4.1 0.5
Lung FEV1/FVC ratio 0.4 1.8 4.4 1.9 0.2 -1.4 -0.8 2.1 0.5
Lung FVC 0.4 2.1 7.0 -1.1 2.6 -2.0 0.2 0.1 0.2
Neuroticism 0.8 2.0 5.0 -1.4 0.6 0.7 2.2 1.6 -1.1
Chronotype (morning person) 0.3 0.8 1.7 -0.7 0.9 1.3 -0.8 0.3 0.9
Hair Pigment 0.1 2.5 7.3 -2.7 -1.6 -0.4 0.2 -1.9 1.2
Tanning 0.1 0.9 1.6 -0.5 -1.0 -1.3 -1.1 -0.6 0.9
Hand grip strength (left) 0.0 0.1 0.3 -0.5 -0.0 -0.1 -0.0 -0.3 -0.5
Number of treatments/medications taken 0.9 1.6 3.6 1.1 0.8 0.1 1.9 1.8 -0.9
Average weekly spirits intake 0.7 0.8 2.2 -0.3 -0.5 -1.3 1.0 0.0 -1.5
Sensitivity / hurt feelings 1.2 2.0 5.5 -2.4 -2.0 -0.7 1.1 -0.6 -0.3
Frequency of depressed mood in last 2 weeks 0.7 0.9 1.9 0.4 0.0 -1.3 0.8 1.0 -1.4
Hearing difficulty/problems: Yes 1.4 2.1 8.4 1.6 -0.4 -2.9 -0.3 -1.1 0.3
Relative age of first facial hair 0.5 1.1 2.8 -1.6 0.4 -0.7 1.7 0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 5.9 -0.0 0.6 -0.6 0.6 2.4 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 -1.1 -0.1 -0.5 -0.9 -0.0 -0.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.6 -1.3 -1.1 0.4 -0.8 -0.8 -0.2
Systolic blood pressure, automated reading 0.3 1.0 2.8 -0.9 0.6 -0.5 1.7 1.3 -0.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.5 -1.9 0.3 -0.3 1.0 0.1 -0.8
Angina 1.1 1.4 5.6 2.4 0.6 0.7 0.2 1.0 -0.9
Medication for hormone replacement therapy 0.6 0.7 1.3 0.8 -1.0 -0.7 -0.7 -0.0 1.1
Vitamin and mineral supplements 0.4 0.5 1.9 0.4 0.2 1.4 -0.5 0.3 -0.9
Supplements: Zinc 0.7 0.8 1.7 1.1 0.0 -1.2 0.4 -0.4 -1.3
Medication: Co-codamol 1.1 1.2 3.0 0.6 0.7 -1.0 -1.7 0.6 -1.5
Medication: Metformin 1.1 1.6 3.9 1.2 1.8 0.4 -0.5 2.0 0.7
Diabetes (father) 0.4 0.5 1.6 0.6 0.2 0.3 -1.2 0.5 0.7
Diabetes (mother) 2.1 2.6 6.7 1.2 1.8 -0.1 2.0 2.6 -0.1
Severe depression (siblings) 0.2 0.3 0.6 -0.2 -0.5 -0.4 0.1 0.7 -0.7
Pack years adult smoking proportion 0.7 1.1 1.6 1.3 0.7 1.1 1.1 1.3 -0.8
Impedance of leg (right) 0.7 3.2 8.8 2.3 -3.0 -0.1 -0.5 -2.3 0.3
Leg fat-free mass (left) 0.1 0.7 1.9 -1.2 0.7 -0.2 1.4 -0.0 -0.7
Trunk fat percentage 0.5 1.8 5.4 2.3 -0.9 0.1 2.0 0.0 -0.7
Hand grip strength (right) 0.1 0.3 0.8 0.7 0.1 -0.9 0.2 -0.2 -0.6
Townsend deprivation index at recruitment 0.6 0.9 1.9 -0.4 0.6 -1.2 -0.4 1.4 1.2
Current tobacco smoking 1.3 2.1 4.9 -0.5 1.4 1.2 2.2 2.1 0.3
Average weekly fortified wine intake 0.4 0.5 1.7 0.2 1.3 -0.1 -0.1 1.1 -0.2
Maternal smoking around birth 0.6 0.9 1.7 0.9 -0.1 -0.8 1.3 0.9 -1.3
Fed-up feelings 1.1 2.1 3.9 -1.4 0.2 -1.7 2.0 1.3 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.7 0.4 -0.8 -0.7 -0.1 -0.4 -1.3
Relative age voice broke 0.4 0.6 1.7 -1.3 0.1 -0.3 1.1 0.8 -0.2
Taking other prescription medications 0.5 0.8 1.7 0.4 0.4 0.2 0.9 1.3 -1.3
Age when periods started (menarche) 0.7 1.6 5.9 -1.1 -0.5 -1.3 -0.0 -0.8 2.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 1.2 0.5 0.1 -0.2 -0.4 1.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.2 3.7 0.3 -0.2 -0.2 1.9 0.4 -1.9
Tinnitus: Yes, but not now, but have in the past 2.3 2.5 5.6 0.9 1.2 -2.0 1.5 2.4 -0.8
Qualifications: CSEs or equivalent 0.5 0.7 2.4 0.7 0.2 -0.2 -0.3 1.0 1.6
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.1 0.7 -0.4 0.8 0.9 -0.4
High blood pressure 0.8 2.1 6.0 1.6 0.6 1.4 1.2 2.4 -0.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.6 0.8 0.5 -1.3 -0.1 0.1 -0.7
Multivitamins +/- minerals 0.3 0.4 1.6 0.5 -0.1 -0.7 -0.3 -0.5 1.3
Stomach or abdominal pain in last month 1.0 1.2 3.1 0.8 1.2 -0.8 0.6 1.8 -1.0
Supplements: Glucosamine 0.8 1.0 5.8 0.4 0.3 -2.4 -0.1 -0.1 -0.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.6 -0.0 0.3 0.2 0.3 -0.1
Medication: Atenolol 0.8 1.0 2.7 1.5 1.1 -0.1 0.3 1.6 0.2
Medication: Levothyroxine sodium 0.0 0.1 0.2 0.4 0.2 -0.4 0.3 0.0 0.1
Sitting height 0.3 2.2 4.2 -0.8 -1.6 -1.3 0.7 -2.0 -1.9
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 -0.8 1.2 0.3 -0.0 0.8 1.3
High blood pressure (mother) 0.5 0.7 1.8 -1.2 0.3 -0.4 0.1 0.8 -1.3
Body mass index (BMI) 0.3 1.4 3.1 1.8 0.7 0.2 1.6 1.4 -0.6
Impedance of leg (left) 0.6 2.7 7.5 2.1 -2.7 0.3 -0.5 -2.0 0.3
Leg predicted mass (left) 0.1 0.7 1.9 -1.1 0.7 -0.2 1.4 0.0 -0.6
Trunk fat mass 0.4 1.6 4.6 2.0 -0.6 -0.2 2.1 0.0 -0.8
Waist circumference 0.4 1.4 2.5 1.6 0.5 0.4 1.3 1.3 -1.4
Number of incorrect matches in round 1.2 2.0 4.7 -2.2 -0.7 -0.6 2.0 -1.0 -1.1
Past tobacco smoking 0.6 1.0 3.5 1.5 0.4 -0.3 -1.9 0.4 -0.1
Alcohol usually taken with meals 1.0 1.6 4.5 2.1 -1.3 -0.0 -0.7 -1.6 0.5
Nervous feelings 0.8 1.5 4.8 -2.2 1.2 0.7 1.0 0.7 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.5 0.3 -0.6 -0.7 0.4 0.2 -0.5
Hearing difficulty/problems with background noise 1.4 2.2 7.5 1.9 -0.5 -2.7 -0.5 -1.0 0.9
Hair/balding pattern: Pattern 2 0.6 0.7 2.0 0.2 -0.1 1.3 0.7 -0.5 1.4
Had menopause 0.5 0.7 1.4 -1.2 0.4 0.5 0.3 -1.1 1.0
Had other major operations 1.1 1.4 2.4 0.5 -1.5 -0.2 -1.5 -1.2 1.4
Forced vital capacity (FVC) 0.2 0.9 2.0 -1.4 1.4 -0.0 -0.0 -0.9 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.8 -0.5 -0.2 0.2 1.9 0.4 -1.5
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 5.8 -1.0 -1.2 -0.3 -0.5 -0.1 -2.4
Qualifications: None of the above 0.4 0.9 2.8 -1.7 0.6 -0.8 0.9 0.8 0.2
Financial difficulties in last 2 years 0.6 0.8 3.0 -0.8 0.7 -0.6 0.1 1.7 0.3
Mouth/teeth dental problems 0.2 0.3 0.8 -0.9 0.6 0.5 -0.8 0.0 0.2
Heart attack 0.4 0.5 1.1 0.7 -0.5 1.0 0.8 -0.6 -0.6
Allergy 0.2 0.6 2.2 -0.1 -1.5 0.5 -0.0 -0.5 0.8
Pain all over the body in last month 0.8 0.9 1.8 0.0 -1.2 -1.0 -0.8 0.6 -1.3
Diabetes (self-reported) 1.5 2.3 8.1 1.5 1.7 -0.3 -0.9 2.9 -0.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.1 0.1 0.2 -0.3 0.5 0.3 -1.0
Medication: Ramipril 1.6 2.0 5.4 2.3 1.1 -0.9 1.1 1.6 -1.0
Medication: Simvastatin 2.1 3.1 12.6 1.0 0.8 1.6 -0.3 3.5 1.3
Fluid intelligence score 0.9 1.8 5.3 1.8 -0.6 1.1 -2.3 0.4 0.3
Illnesses of siblings 1.4 1.9 7.1 -0.5 -1.8 -0.2 -0.9 -2.7 -0.0
Neuroticism score 1.0 2.0 6.1 -1.9 -0.1 0.4 2.5 1.2 -1.0
Weight 0.2 1.0 3.1 0.8 0.2 -0.4 1.8 0.1 -1.3
Impedance of arm (right) 0.3 1.6 5.3 0.4 -1.9 0.6 0.4 -2.3 0.4
Arm fat percentage (right) 0.5 2.1 6.5 2.3 -0.3 0.3 2.5 0.4 -0.5
Trunk fat-free mass 0.2 1.3 2.3 -1.3 0.3 -1.4 1.3 -0.5 -1.5
Hip circumference 0.3 1.2 4.6 2.1 0.1 0.9 1.1 0.4 0.7
Time employed in main current job 2.1 2.4 4.5 2.1 2.1 1.3 -1.3 1.2 0.7
Alcohol intake versus 10 years previously 0.3 0.4 1.2 0.0 -1.1 0.7 -0.5 -0.2 0.7
Father’s age at death 1.3 1.8 5.2 0.2 -1.1 -0.8 -1.9 -2.3 0.3
Worrier / anxious feelings 1.1 2.1 6.4 -1.4 -0.1 2.5 -0.8 1.5 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.3 1.2 -0.5 -1.1 1.1 1.5 -0.5
Falls in the last year 0.7 0.9 2.4 1.5 -0.2 0.5 1.0 1.3 -0.3
Hair/balding pattern: Pattern 3 0.8 1.2 3.9 -1.2 -0.3 -2.0 -0.9 -1.1 -0.0
Number of live births 0.8 1.1 3.9 -0.6 -0.2 -2.0 -0.3 -0.4 -1.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.0 -0.2 1.1 0.0 -1.3 -0.3 1.4
Pulse rate 1.3 2.2 6.7 -0.8 -0.4 2.2 -0.8 -0.6 2.6
Happiness 1.0 1.3 1.9 -0.4 -1.4 -1.1 1.1 -1.1 -1.3
Noisy workplace 0.8 1.0 3.2 -0.2 0.1 -1.8 0.0 -1.5 -0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.6 -0.2 -0.3 1.0 0.0 -0.1 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.2 1.0 -0.2 -0.3 0.1 1.5 -0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 2.9 0.5 -1.7 -0.8 0.9 -1.1 -0.1
Asthma 0.3 0.7 2.2 -1.1 1.5 0.5 0.3 0.4 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.5 -0.1 -0.0 0.2 -0.0 -0.2 -0.7
Medication: Cholesterol lowering 1.5 2.3 8.5 2.9 0.5 -0.7 0.1 2.0 -0.7
Depression (self-reported) 0.9 1.1 3.0 -0.8 -1.6 -0.5 -0.1 -0.5 -1.7
Medication: Lansoprazole 0.9 1.0 2.5 0.1 -0.5 -0.8 0.9 1.6 -1.4
Prospective memory result 1.7 2.1 4.6 -2.0 -0.7 1.4 2.1 -1.0 0.8
Lung cancer (father) 0.6 0.8 1.6 0.6 -1.0 0.3 1.2 -1.2 -0.5
Illnesses of mother 0.6 0.7 2.2 0.7 -0.1 1.5 -0.2 -0.8 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.5 -0.5 0.2 -1.0 -1.2 -1.1 0.8
Pulse wave Arterial Stiffness index 0.6 0.7 1.5 -0.1 -0.5 0.6 1.2 0.9 -1.0
Impedance of arm (left) 0.2 1.0 2.8 0.3 -1.4 0.8 -0.1 -1.7 0.6
Arm fat mass (right) 0.4 1.6 6.1 1.6 -0.2 0.0 2.5 0.4 -0.8
Trunk predicted mass 0.2 1.4 2.3 -1.3 0.2 -1.4 1.4 -0.6 -1.5
Standing height 0.3 3.1 7.6 -1.8 -0.9 -1.8 1.0 -2.8 -1.8
Length of working week for main job 0.8 0.9 2.0 0.7 -0.9 -0.7 1.4 -1.0 -0.7
Exposure to tobacco smoke at home 1.1 1.2 3.9 1.5 -0.2 2.0 0.6 0.7 -0.0
Breastfed as a baby 1.0 1.3 3.4 0.4 1.8 -0.3 0.9 1.8 -0.2
Tense / ‘highly strung’ 1.0 1.6 4.2 -1.3 0.4 0.6 2.0 0.8 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.8 -0.2 0.5 -0.2 1.1 0.9 -1.3
Hair/balding pattern: Pattern 4 0.7 1.6 3.8 -0.5 0.9 -2.0 -0.9 0.9 -1.8
Birth weight of first child 1.1 2.0 5.3 -1.4 -1.5 0.1 1.4 -2.3 -0.7
Peak expiratory flow (PEF) 0.4 1.0 3.6 1.9 0.6 0.1 -0.6 1.1 0.7
Pulse wave reflection index 0.7 0.8 2.1 1.1 0.1 -0.1 1.2 0.4 -1.4
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.1 0.5 -1.8 -0.5 0.5 -1.0 -1.8
Loud music exposure frequency 0.2 0.2 1.1 -1.1 0.3 -0.1 0.0 0.2 0.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.1 0.9 0.7 1.3 -0.9 -0.3 1.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.7 -0.7 0.7 -0.2 0.2 0.1 0.8
Blood clot in the leg (DVT) 0.2 0.3 1.1 0.6 0.2 0.1 -0.1 0.0 -1.1
Medication: Paracetamol 0.2 0.3 1.2 0.6 0.2 -1.1 0.3 0.0 0.1
Headache pain in last month 0.4 0.7 1.4 -0.3 1.2 -0.8 0.8 0.7 -0.9
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 10.9 -2.1 -1.5 0.3 -0.9 -3.3 0.2
Glaucoma (self-reported) 0.3 0.3 0.8 0.3 0.9 -0.0 0.3 -0.5 -0.8
Gout (self-reported) 1.5 2.1 6.3 -0.7 1.4 0.2 1.1 2.5 -1.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.7 0.3 0.4 -0.8 0.2 -0.1 -0.3
Medication: Amlodipine 1.8 2.6 6.5 0.2 1.7 2.4 0.7 2.5 -0.3
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.5 -2.1 1.4 -0.0 1.9 0.2 -0.7
Birth weight 0.6 1.3 4.5 -2.1 -0.2 -1.5 0.4 -1.0 0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.8 -1.0 -1.3 -0.3 0.9 -0.1 -1.1
High blood pressure (siblings) 0.8 1.1 3.3 1.8 0.0 0.7 0.4 1.7 0.1
Forced vital capacity (FVC), Best measure 0.3 1.0 4.0 -1.4 0.1 -0.4 -0.3 -2.0 0.4
Body fat percentage 0.6 2.2 7.8 2.8 -0.9 0.1 2.1 0.2 -0.5
Leg fat percentage (right) 0.9 3.2 14.8 3.9 -0.8 0.2 1.8 0.7 0.1
Arm fat-free mass (right) 0.1 0.7 1.4 -0.8 0.2 -1.2 0.9 -0.2 -1.1
Exposure to tobacco smoke outside home 1.3 1.7 4.7 0.3 -0.1 2.2 -1.2 0.2 2.1
Comparative body size at age 10 0.5 1.5 4.2 -1.4 1.6 0.2 -0.1 2.1 -0.0
Number of full brothers 1.0 1.3 3.2 0.4 0.6 -1.8 1.3 0.9 -1.1
Worry too long after embarrassment 0.5 0.9 2.3 -1.5 0.2 0.5 1.4 0.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 6.4 0.1 0.9 0.1 2.5 1.9 -1.2
Wheeze or whistling in the chest in last year 0.6 1.0 2.4 -0.7 1.6 0.9 0.2 1.0 -1.2
Number of children fathered 0.6 0.6 2.7 -0.1 0.7 0.4 0.3 1.6 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 4.6 0.3 0.7 1.1 -2.1 0.5 -0.2
Age at first live birth 1.2 2.2 5.4 -0.1 -0.6 2.3 -1.6 -1.8 1.2
Pulse wave peak to peak time 0.5 0.6 1.4 -0.1 0.4 -0.5 -1.0 -1.2 0.8
Health satisfaction 1.0 1.3 2.0 0.2 -1.3 -1.1 -1.1 -1.4 -1.4
Shortness of breath walking on level ground 0.9 1.1 2.7 -0.2 -1.6 -1.0 -1.1 -1.3 -0.1
Qualifications: College or University degree 0.2 0.6 1.7 1.0 -0.3 1.3 0.3 0.1 1.0
Eye problems/disorders: None of the above 1.0 1.1 2.8 0.8 -0.5 0.5 -1.6 -1.7 -0.6
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.5 -0.4 1.2 0.5 0.8 1.1 0.6
Emphysema/chronic bronchitis 0.9 1.0 2.2 -0.7 -1.5 -1.4 0.5 -0.5 -0.9
Medication for pain relief, constipation, heartburn 0.3 0.6 1.4 -0.2 -0.8 0.7 -0.4 -0.8 1.2
Neck or shoulder pain in last month 0.3 0.4 1.4 0.1 0.1 1.2 -0.9 -0.2 -0.3
Medication: Blood pressure 1.3 2.3 6.7 0.8 1.7 0.3 1.8 2.6 -0.5
Angina (self-reported) 0.8 1.1 5.1 2.3 0.3 0.5 0.1 0.7 -0.8
Migraine (self-reported) 1.5 1.9 7.7 -2.8 -0.6 0.6 1.5 -0.2 -0.8
Medication: Ibuprofen 0.3 0.3 1.8 0.3 0.0 0.2 1.3 0.2 -0.2
Medication: Allopurinol 2.6 3.4 9.8 0.5 1.5 -0.8 1.5 3.1 -2.3
Medication: Omeprazole 2.2 2.6 10.3 -0.1 0.0 -3.2 -0.7 0.1 -2.2
Medication: Seretide 50 evohaler 0.9 1.0 2.0 -1.2 1.4 0.9 -0.6 1.0 0.7
Mean time to correctly identify matches 0.2 0.4 1.0 -0.9 0.7 -0.4 1.0 -0.2 0.4
Heart disease (mother) 0.6 0.7 2.8 1.7 -0.7 0.8 -0.6 0.3 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 1.5 -0.6 0.5 -0.4 -1.2 0.8 0.3
Whole body fat mass 0.4 1.6 4.8 2.0 -0.4 -0.1 2.2 0.3 -0.5
Leg fat mass (right) 0.6 2.1 8.8 3.0 -0.5 0.2 1.9 0.3 -0.1
Arm predicted mass (right) 0.2 0.9 2.0 -0.7 0.4 -1.4 1.0 -0.0 -1.3
Pulse rate, automated reading 0.8 2.6 7.3 -1.4 0.7 2.7 -0.8 0.4 2.3
Alcohol intake frequency. 0.2 0.6 1.9 -0.1 0.7 0.6 0.8 1.4 -0.2
Comparative height size at age 10 0.2 0.9 3.0 -0.6 0.4 0.5 0.4 -1.3 -1.7
Number of full sisters 0.7 0.8 1.7 -1.3 0.6 0.6 1.0 0.8 0.9
Suffer from ‘nerves’ 0.7 1.2 2.1 -0.9 1.1 1.4 1.4 0.9 -0.0
Overall health rating 0.7 1.4 5.3 2.3 0.2 0.9 0.6 1.4 -0.6
Chest pain or discomfort 0.5 0.8 1.6 0.8 0.8 -0.3 0.3 1.3 -1.1
Had major operations 1.1 1.3 5.9 2.4 0.1 0.6 0.2 1.3 -0.4
Age at last live birth 1.8 2.6 7.5 -0.2 -1.1 0.4 -2.7 -2.3 1.0
Family relationship satisfaction 0.5 0.6 1.6 0.2 -0.6 -0.5 1.3 0.2 -1.2
Leg pain on walking 0.8 1.0 2.5 0.4 -0.4 -1.6 0.9 -0.4 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.9 0.5 -0.4 -0.6 0.1 -1.0 -0.8
Commuting to job workplace: Car/motor vehicle 0.8 1.0 2.5 -0.4 0.7 1.5 -0.6 0.3 1.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.5 -0.3 -0.1 0.2 -0.7 -1.2 0.9
Medication: Aspirin 0.9 1.1 2.7 1.6 0.4 1.2 0.2 1.6 0.1
Supplements: Vitamin C 0.4 0.5 1.7 -1.3 -0.3 0.8 -0.6 -0.5 0.0
Knee pain experienced in last month 0.9 1.5 6.3 -1.3 0.1 -0.4 2.5 0.4 -0.6
Hypertension (Self-reported) 0.7 1.8 5.0 1.1 0.5 1.7 1.1 2.2 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.0 -0.6 0.8 -1.4 0.5 1.2 -1.4
Illnesses of father: Heart disease 0.5 0.7 1.7 1.3 0.4 0.8 -0.4 1.2 0.3
Illnesses of siblings: Diabetes 2.3 2.8 6.8 -1.0 2.6 -0.4 1.0 2.5 -1.3
Smoking status: Previous 0.7 1.1 2.7 -1.6 -0.8 0.7 1.3 -1.1 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 9.7 -1.6 -1.5 0.8 -2.2 -3.1 0.3
Whole body fat-free mass 0.2 1.1 2.2 -1.2 0.6 -0.9 1.5 -0.3 -1.2
Leg fat-free mass (right) 0.2 1.0 2.5 -1.6 0.9 -0.0 1.4 0.1 -0.7
Arm fat percentage (left) 0.5 1.8 5.2 2.3 -0.3 0.5 2.2 0.6 -0.3
Average weekly red wine intake 0.9 1.4 4.3 0.1 -1.8 0.0 0.9 -2.1 -0.2
Handedness (chirality/laterality): Left-handed 1.3 1.6 5.0 -1.0 -1.1 0.0 -1.3 -2.2 -0.6
Mood swings 1.0 1.8 5.8 -0.9 -1.2 -0.8 1.4 -0.3 -2.4
Loneliness, isolation 0.0 0.1 0.2 0.0 0.2 -0.4 0.3 0.2 -0.2
Long-standing illness, disability or infirmity 0.7 1.0 4.0 0.4 -0.5 -0.7 2.0 0.5 -0.9
Ever had bowel cancer screening 0.8 1.0 4.2 2.0 0.3 0.5 -0.1 0.7 -0.9
Diabetes diagnosed by doctor 1.7 2.8 8.9 1.4 2.0 -0.2 -1.2 3.0 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 4.3 0.0 0.8 2.1 1.4 1.1 0.2
Friendships satisfaction 1.6 1.9 4.9 -0.3 -1.7 -2.2 1.4 -0.5 -1.2
Qualifications: nursing, teaching 1.1 1.7 3.3 1.8 -0.7 -1.1 1.8 -1.0 -1.0
Commuting to job workplace: Walk 0.6 0.6 1.0 -0.6 -0.9 -0.6 0.5 -1.0 -0.9
Eye problems/disorders: Cataract 1.2 1.4 5.5 -0.5 0.4 0.2 0.2 2.4 1.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.7 -0.5 0.8 -1.3 -0.2 0.3 -0.6
Medication for cholesterol 1.0 1.4 4.1 -1.0 0.5 -2.0 -0.1 -1.6 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 6.9 -1.1 -2.6 -0.5 -0.7 -1.7 -1.9
Back pain experienced in last month 0.2 0.3 1.1 -0.4 -0.2 1.0 -0.4 0.5 -0.0
Mineral and other dietary supplements 1.0 1.4 4.4 0.2 0.6 1.6 0.2 2.1 -1.1
Breast cancer (self-reported) 0.4 0.5 1.3 0.2 -1.1 0.6 0.3 -1.1 -0.4
Asthma (self-reported) 0.4 0.8 2.7 -1.1 1.6 0.6 0.5 0.5 -0.4
Osteoporosis (self-reported) 2.0 2.5 9.1 -0.7 3.0 -0.6 1.0 2.0 -0.1
Osteoarthritis (self-reported) 1.3 1.7 6.3 0.3 -2.5 0.2 0.0 -1.8 0.6
Medication: Aspirin 1.2 1.5 4.1 1.4 0.6 1.4 0.9 2.0 0.2
Medication: Gliclazide 0.8 0.9 3.2 1.8 0.1 0.2 -1.3 0.7 -0.3
Illnesses of father: None of the above (group 1) 2.2 2.8 5.1 0.7 -0.9 -2.2 1.1 -2.0 -2.3
Smoking status: Current 0.9 1.5 3.2 -0.5 1.1 0.9 1.8 1.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.2 -0.9 0.6 -1.5 -1.2 -0.5 -0.5
Whole body water mass 0.2 1.1 2.0 -1.3 0.5 -1.0 1.4 -0.2 -1.2
Leg predicted mass (right) 0.2 1.0 2.6 -1.6 0.9 -0.0 1.4 0.1 -0.7
Arm fat mass (left) 0.3 1.4 5.0 1.7 -0.2 0.0 2.2 0.6 -0.7
Number of self-reported non-cancer illnesses 1.3 2.3 5.9 -0.8 0.4 0.2 2.1 1.6 -2.4
Average weekly champagne plus white wine intake 1.9 2.6 9.9 1.2 0.4 1.2 -1.3 1.1 3.1
Miserableness 1.6 2.8 8.9 0.9 -0.5 -2.1 3.0 1.2 -1.0
Guilty feelings 1.4 2.0 4.2 -2.0 0.2 -0.8 2.0 0.7 -1.7
Wears glasses or contact lenses 1.0 1.2 4.1 2.0 0.4 0.5 1.4 -0.2 -0.7
Ever taken oral contraceptive pill 1.0 1.2 4.5 0.6 0.2 2.1 -0.1 -0.6 1.3
Hearing aid user 0.5 0.6 1.3 -0.0 0.8 -0.4 -1.1 -1.0 -0.6
Mother’s age at death 1.6 1.9 4.9 0.8 2.2 -1.0 -0.7 1.2 1.8
Financial situation satisfaction 0.4 0.4 1.1 -1.0 -0.9 0.1 -0.5 -0.6 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.5 0.9 0.3 -1.6 0.1 -0.6 0.4
Commuting to job workplace: Public transport 1.0 1.2 6.2 0.7 0.3 0.6 -2.5 0.4 -0.1
Eye problems/disorders: Glaucoma 0.2 0.2 1.0 0.1 1.0 0.5 0.1 -0.3 0.3
Medication: Blood pressure 1.5 2.8 11.7 0.5 0.8 3.4 0.5 2.1 0.1
Pain type(s) experienced in last month: Hip pain 1.5 1.9 7.1 1.0 -0.6 1.6 -2.7 -0.6 0.2
Supplements: Fish oil (including cod liver oil) 1.0 1.3 5.0 -0.8 -1.0 -0.6 0.6 -2.2 0.7
High cholesterol (Self-reported) 0.4 0.7 1.8 0.3 -1.4 -0.4 -0.8 0.8 -1.1
Medication: Bendroflumethiazide 1.5 2.2 4.9 -0.0 1.8 2.2 -0.3 2.2 0.4
Medication: Paracetamol 0.2 0.3 1.0 0.3 0.1 -0.2 1.0 -0.1 0.9
Medication: Lisinopril 0.2 0.3 0.8 -0.3 -0.2 0.5 0.9 -0.5 0.5
Medication: Atorvastatin 1.6 1.9 4.9 1.0 0.1 -2.1 0.9 0.6 -2.2
Illnesses of father: High blood pressure 0.5 0.6 1.9 1.0 -0.6 1.4 -0.6 0.3 -0.1
Alcohol drinker status: Never 0.5 0.6 2.7 0.7 0.5 0.5 -0.1 1.6 -0.1
Ever smoked 0.3 0.5 1.4 -0.7 0.2 0.3 1.2 0.1 1.0
Basal metabolic rate 0.2 1.0 2.8 -0.8 0.3 -0.8 1.7 -0.2 -1.3
Leg fat percentage (left) 0.7 2.7 11.7 3.4 -0.5 0.5 1.7 0.9 0.1
Arm fat-free mass (left) 0.2 1.2 2.8 -0.4 0.3 -1.5 1.7 0.0 -1.4
Number of operations (self-reported) 0.7 1.1 2.9 1.7 0.5 -1.0 0.4 1.3 -0.8
Average weekly beer plus cider intake 1.0 1.4 5.2 -2.3 0.2 -0.3 1.3 0.1 -1.2
Irritability 0.5 0.8 1.8 -0.3 0.3 1.0 1.3 1.3 -0.1
Risk taking 2.8 4.0 10.6 -0.3 -3.2 -1.1 0.0 -1.4 -3.2
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.0 1.3 -0.8 -0.8 1.2 0.5 -1.4
Fractured/broken bones in last 5 years 0.8 1.0 4.6 0.1 -0.2 2.1 1.0 -0.2 0.6
Age started oral contraceptive pill 0.6 0.7 2.2 -0.9 0.6 -0.6 -1.5 -0.6 0.1
Diastolic blood pressure, automated reading 0.1 0.3 0.8 -0.8 -0.1 0.6 0.9 -0.1 -0.3
Ever depressed for a whole week 0.3 0.4 1.2 -0.5 -0.6 -0.2 0.5 0.5 -1.1
Unable to work because of sickness or disability 0.4 0.5 1.5 0.5 -0.9 0.7 -1.2 0.4 -0.0
Commuting to job workplace: Cycle 0.4 0.5 2.2 -1.5 -0.1 0.2 -0.0 -0.3 -0.8
Myopia 0.9 1.3 3.2 1.3 -0.6 -0.3 1.4 0.7 -1.8
Vascular/heart problems diagnosed by doctor 0.9 2.6 6.1 -2.1 -0.5 -1.5 -1.4 -2.5 0.5
Cholesterol lowering medication 1.0 1.5 5.0 -0.6 -0.6 2.2 0.4 1.8 0.5
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 8.7 0.1 -0.6 -3.0 -1.3 -0.1 -2.4
Pain experienced in last month 0.2 0.4 1.1 -0.1 -0.9 -0.1 0.2 -1.1 0.5
Supplements: Calcium 1.1 1.2 3.8 0.3 -0.5 0.5 -2.0 -1.6 0.3
Basal cell carcinoma (self-reported) 1.3 1.6 3.5 -0.9 -0.6 -0.5 1.7 -1.3 -1.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 0.8 -0.6 0.9 1.0 -0.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.9 0.5 0.2 0.2 -0.3 -0.2 -0.9
Heart disease (siblings) 1.3 1.5 4.6 1.4 1.1 -0.7 0.9 2.1 -0.3
Alcohol drinker status: Previous 2.1 2.4 5.0 -0.6 2.2 -1.1 1.6 2.2 -0.7
Pack years of smoking 0.6 0.9 1.4 1.2 0.8 0.9 1.1 1.0 -0.7
Impedance of whole body 0.4 1.8 4.8 1.2 -2.2 0.4 -0.3 -2.0 0.5
Leg fat mass (left) 0.4 1.7 6.5 2.5 -0.2 0.3 1.8 0.6 -0.0
Arm predicted mass (left) 0.3 1.3 2.9 -0.9 0.3 -1.2 1.7 -0.1 -1.6