Hub : Genes

RSPO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Lung Squamous Cell Carcinoma 0.0586 0.0283 5.7e-03 0.004 0.012 -0.001 NA 0.001 0.11000 1.3e-02 5.4e-01 NA 2.7e-01
2 TCGA Prostate Adenocarcinoma 0.0988 0.0385 3.0e-06 0.029 0.047 0.038 NA 0.040 0.00042 1.1e-05 7.2e-05 NA 4.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.3 1.4 -1.1 -1.2
Bipolar Disorder or Schizophrenia 0.3 0.7 1.3 -1.1 -0.4
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 -0.3 -0.1
Depression (Nagel 2018) 0.8 1.2 1.5 -0.9 -1.2
Intelligence (Savage-Jansen 2018) 1.2 3.7 7.4 0.3 2.7
Neuroticism (Nagel 2018) 0.1 0.1 0.2 -0.2 0.5
Schizophrenia (2018) 0.2 0.4 0.6 -0.8 0.5
Schizophrenia vs Biploar Disorder 0.5 0.7 1.3 -0.0 1.1
Worry (Nagel 2018) 0.3 0.6 0.9 -1.0 0.5
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 -0.3 -0.8
Alzheimer’s Disease (in father) 0.4 0.5 0.5 0.7 0.6
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.2 -0.6
Crohns Disease (2017) 0.9 2.0 4.0 -0.1 -2.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.6 -0.2
Ulcerative Colitis (UC) 0.5 1.0 1.3 0.9 1.1
Major Depression (MDD) 5.9 7.2 13.7 -0.8 -3.7
Reaction Time 0.7 1.2 1.3 1.1 -1.1
Verbal and Numeric Reasoning (VNR) 1.0 2.5 4.7 0.5 2.2
Breast Cancer 0.1 0.3 0.6 0.7 -0.0
Ovarian Cancer 5.6 7.4 8.9 3.0 2.4
Prostate Cancer 1.4 2.0 3.9 2.0 0.2
Age at First Birth 0.0 0.1 0.1 -0.3 -0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.0 1.0 -0.6
Coronary Artery Disease (CAD) 0.7 0.8 0.9 1.0 -0.8
Crohns Disease (2012) 0.6 0.9 1.6 -0.5 -1.3
Mean Putamen Volume 0.9 1.1 1.7 -0.7 1.3
Fasting Glucose 0.9 1.1 2.0 1.4 -0.4
HbA1C 1.6 1.7 2.7 -0.9 -1.6
HDL Cholesterol 1.1 1.8 3.5 1.9 -0.1
LDL Cholesterol 0.2 0.4 0.7 -0.0 -0.9
Lupus 0.4 0.6 0.9 -0.6 0.9
Neuroticism (2016) 0.3 0.4 0.8 -0.1 -0.9
Primary Biliary Cirrhosis 0.1 0.2 0.3 -0.4 0.5
Rheumatoid Arthritis 0.4 0.6 0.7 -0.7 -0.8
Schizophrenia (2014) 0.3 0.6 0.6 -0.7 -0.8
Triglycerides 1.3 2.1 2.6 -1.2 -1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.0
Ulcerative Colitis 1.7 2.5 4.1 1.0 2.0
Blood Eosinophil Count 0.3 2.4 4.7 -0.2 2.2
Blood Platelet Count 0.4 5.2 7.7 -1.6 -2.8
Blood Red Count 0.4 3.7 7.2 -0.4 -2.7
Blood White Count 0.4 3.0 3.2 -1.8 -1.7
Heel T-Score 0.8 6.2 12.1 -0.5 -3.5
BMI 0.3 1.9 2.0 1.3 -1.4
Height 0.5 10.2 20.3 0.3 4.5
Waist Hip Ratio (WHR) 0.5 2.2 3.0 -1.2 1.7
Systolic Blood Pressure 0.0 0.2 0.3 -0.5 0.5
Smoking Status 0.6 1.5 3.0 1.7 -0.1
Allergy or Eczema 1.3 3.4 6.2 -2.5 -0.8
Cardiovascular Disease 0.5 1.5 3.0 0.3 -1.7
Hypothyroidism (self reported) 0.5 1.1 1.5 -1.2 0.8
Respiratory disease 0.5 1.0 1.9 1.4 0.4
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 -0.7 0.1
Lung FEV1/FVC ratio 4.3 22.0 39.8 -6.3 -2.1
Lung FVC 0.2 1.2 2.0 -0.7 1.4
Neuroticism 0.3 0.7 1.2 -1.1 -0.3
Chronotype (morning person) 1.6 3.8 6.0 -1.2 -2.5
Hair Pigment 0.0 1.1 2.2 1.5 -0.3
Tanning 0.1 1.7 3.3 0.1 -1.8
Hand grip strength (left) 0.1 0.4 0.8 0.1 0.9
Number of treatments/medications taken 1.0 1.9 3.7 -0.2 -1.9
Average weekly spirits intake 2.7 3.4 4.8 2.2 -1.4
Sensitivity / hurt feelings 0.3 0.5 0.7 -0.8 -0.5
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.9 -0.3 -1.0
Hearing difficulty/problems: Yes 0.8 1.3 1.9 -0.8 -1.4
Relative age of first facial hair 0.3 0.5 1.0 0.2 1.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.2 -1.1 -0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.1 -0.4
Ever had hysterectomy (womb removed) 0.6 0.7 0.8 0.8 -0.9
Systolic blood pressure, automated reading 0.2 0.6 1.0 0.4 1.0
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 -0.8 0.5
Angina 0.4 0.5 0.8 -0.5 -0.9
Medication for hormone replacement therapy 1.4 1.6 2.2 1.5 1.0
Vitamin and mineral supplements 0.1 0.2 0.4 -0.0 0.6
Supplements: Zinc 0.0 0.0 0.1 0.3 0.0
Medication: Co-codamol 5.1 5.9 6.8 -2.6 -2.2
Medication: Metformin 0.8 1.2 2.3 -0.2 -1.5
Diabetes (father) 1.0 1.3 1.6 1.0 1.3
Diabetes (mother) 2.1 2.6 5.1 -2.2 -0.5
Severe depression (siblings) 0.2 0.3 0.5 0.7 0.2
Pack years adult smoking proportion 0.1 0.1 0.1 0.2 -0.4
Impedance of leg (right) 0.0 0.1 0.2 -0.2 -0.4
Leg fat-free mass (left) 0.0 0.1 0.1 -0.2 0.2
Trunk fat percentage 0.9 3.8 7.3 0.5 -2.7
Hand grip strength (right) 0.4 1.1 1.9 0.5 1.4
Townsend deprivation index at recruitment 1.0 1.4 2.6 0.5 -1.6
Current tobacco smoking 1.7 2.8 3.3 1.8 -1.5
Average weekly fortified wine intake 1.4 1.6 2.5 -1.6 -0.9
Maternal smoking around birth 1.7 2.5 4.5 0.7 -2.1
Fed-up feelings 0.2 0.3 0.6 0.2 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.6 -0.8 -0.4
Relative age voice broke 0.5 0.8 1.2 0.6 1.1
Taking other prescription medications 0.4 0.6 1.1 -0.0 -1.1
Age when periods started (menarche) 0.2 0.6 0.9 -0.5 1.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 1.8 -0.8 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.6 -0.2 -1.9
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.7 -1.9 -0.4
Qualifications: CSEs or equivalent 3.5 4.6 6.0 -2.4 -1.8
Serious illness, injury or assault to yourself 3.2 3.9 7.8 -2.8 0.2
High blood pressure 0.5 1.5 1.9 1.1 -1.4
Hayfever, allergic rhinitis or eczema 1.5 3.3 5.9 -2.4 -0.9
Multivitamins +/- minerals 0.1 0.1 0.2 0.0 -0.5
Stomach or abdominal pain in last month 1.1 1.3 2.4 -0.4 -1.6
Supplements: Glucosamine 0.1 0.1 0.2 -0.4 0.2
Diverticular disease/diverticulitis (self-reported) 2.9 3.5 5.3 1.3 2.3
Medication: Atenolol 0.9 1.1 1.4 1.2 0.9
Medication: Levothyroxine sodium 0.0 0.1 0.1 -0.2 -0.3
Sitting height 0.1 0.5 1.0 -0.1 1.0
Chronic bronchitis/emphysema (father) 0.6 0.7 0.9 0.7 -1.0
High blood pressure (mother) 0.1 0.1 0.2 -0.5 -0.2
Body mass index (BMI) 0.5 2.0 2.4 1.6 -1.2
Impedance of leg (left) 0.0 0.0 0.0 0.1 -0.1
Leg predicted mass (left) 0.0 0.1 0.1 -0.3 0.2
Trunk fat mass 0.4 1.8 3.3 0.6 -1.8
Waist circumference 0.1 0.4 0.8 0.9 0.2
Number of incorrect matches in round 3.4 5.7 9.7 -1.3 -3.1
Past tobacco smoking 0.0 0.1 0.1 -0.3 -0.0
Alcohol usually taken with meals 0.4 0.6 1.0 -0.5 1.0
Nervous feelings 0.5 0.9 1.5 1.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 2.4 -1.3 -1.5
Hearing difficulty/problems with background noise 0.8 1.3 1.4 -1.1 -1.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.1 -0.1 1.0
Had menopause 1.7 2.2 4.3 2.1 0.1
Had other major operations 2.9 3.6 7.1 0.2 -2.7
Forced vital capacity (FVC) 1.1 4.2 5.2 -1.8 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.7 -0.0 -1.6
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 0.2 -0.5
Qualifications: None of the above 0.7 1.4 2.9 0.1 -1.7
Financial difficulties in last 2 years 0.7 0.9 1.1 0.8 -1.1
Mouth/teeth dental problems 0.8 1.2 2.4 -0.4 1.5
Heart attack 0.9 1.2 2.3 -0.2 -1.5
Allergy 0.6 1.3 1.7 1.0 1.3
Pain all over the body in last month 0.5 0.5 0.6 0.7 0.8
Diabetes (self-reported) 0.4 0.6 1.3 -1.1 -0.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.2 -0.2 1.5
Medication: Ramipril 1.0 1.3 1.3 -1.1 -1.1
Medication: Simvastatin 0.7 1.1 1.6 -0.7 -1.2
Fluid intelligence score 1.4 3.0 4.0 2.0 1.4
Illnesses of siblings 0.3 0.4 0.4 -0.7 0.5
Neuroticism score 0.4 0.8 1.6 -1.3 0.1
Weight 0.1 0.6 1.2 1.1 -0.0
Impedance of arm (right) 0.8 3.9 5.2 -1.6 -2.3
Arm fat percentage (right) 1.1 4.2 7.5 0.9 -2.7
Trunk fat-free mass 0.6 3.7 6.6 0.9 2.6
Hip circumference 0.2 1.0 1.8 1.4 -0.5
Time employed in main current job 1.0 1.1 1.8 1.3 0.7
Alcohol intake versus 10 years previously 3.0 4.6 7.6 -1.2 -2.8
Father’s age at death 0.6 0.9 0.9 -0.9 0.9
Worrier / anxious feelings 0.7 1.3 2.6 -1.6 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 -1.1 -0.2
Falls in the last year 0.5 0.6 1.2 -1.1 -0.2
Hair/balding pattern: Pattern 3 0.3 0.5 0.6 -0.6 -0.8
Number of live births 0.6 0.9 1.7 0.3 -1.3
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 9.8 -3.1 1.6
Pulse rate 0.6 1.0 1.5 -0.7 -1.2
Happiness 1.6 1.9 2.2 -1.3 -1.5
Noisy workplace 0.5 0.6 0.9 -0.9 0.5
Qualifications: A levels/AS levels or equivalent 3.3 7.4 14.5 -0.5 3.8
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 -0.1 -0.0
Mouth/teeth dental problems: Dentures 0.9 1.5 2.9 -0.4 -1.7
Asthma 0.4 0.7 0.8 0.9 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.4 1.2 -0.8
Medication: Cholesterol lowering 1.6 2.5 3.1 -1.4 -1.8
Depression (self-reported) 1.3 1.6 2.4 -0.9 -1.5
Medication: Lansoprazole 0.8 0.9 1.7 1.3 -0.2
Prospective memory result 0.6 0.7 1.4 0.1 -1.2
Lung cancer (father) 0.1 0.1 0.2 -0.1 0.4
Illnesses of mother 0.8 0.9 1.6 0.5 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.3 12.0 -3.5 0.8
Pulse wave Arterial Stiffness index 0.0 0.1 0.1 0.3 0.1
Impedance of arm (left) 0.9 4.1 5.4 -1.7 -2.3
Arm fat mass (right) 0.4 1.6 2.5 0.8 -1.6
Trunk predicted mass 0.6 3.7 6.5 1.0 2.5
Standing height 0.3 3.4 6.1 -0.8 2.5
Length of working week for main job 1.6 1.7 3.5 -1.9 0.0
Exposure to tobacco smoke at home 0.4 0.5 0.6 -0.6 -0.8
Breastfed as a baby 0.6 0.8 0.8 0.9 0.9
Tense / ‘highly strung’ 0.1 0.2 0.3 -0.6 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 2.3 -0.9 -1.5
Hair/balding pattern: Pattern 4 0.8 1.9 2.8 -1.7 -0.9
Birth weight of first child 0.1 0.2 0.3 -0.2 -0.5
Peak expiratory flow (PEF) 2.2 5.2 7.6 -2.8 1.7
Pulse wave reflection index 1.6 1.9 3.7 1.9 -0.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.5 0.4 -0.7
Loud music exposure frequency 0.9 1.0 1.0 -1.0 -1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 0.8 0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.9 -0.3 -1.4
Blood clot in the leg (DVT) 0.9 1.1 2.1 1.5 -0.4
Medication: Paracetamol 0.2 0.3 0.5 0.7 0.1
Headache pain in last month 0.3 0.6 1.2 1.1 0.0
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 5.7 0.4 2.4
Glaucoma (self-reported) 1.1 1.3 1.9 1.4 0.9
Gout (self-reported) 0.4 0.5 1.0 0.0 1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.9 -0.3 0.9
Medication: Amlodipine 1.2 1.6 1.8 -1.3 -1.2
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.5 -0.6 1.6
Birth weight 0.0 0.0 0.0 -0.0 0.2
Chronic bronchitis/emphysema (mother) 3.7 4.3 8.6 -0.1 -2.9
High blood pressure (siblings) 0.1 0.2 0.3 0.2 0.6
Forced vital capacity (FVC), Best measure 1.1 4.2 5.7 -2.4 1.6
Body fat percentage 1.0 3.8 6.7 0.9 -2.6
Leg fat percentage (right) 1.2 4.3 5.3 2.3 -1.8
Arm fat-free mass (right) 0.3 1.5 2.6 0.6 1.6
Exposure to tobacco smoke outside home 1.5 2.0 3.7 -0.6 -1.9
Comparative body size at age 10 0.8 2.1 4.1 -0.4 2.0
Number of full brothers 3.5 4.4 8.5 -0.6 -2.9
Worry too long after embarrassment 0.6 1.0 1.8 -0.4 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 5.1 6.6 7.2 -2.4 -2.7
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 -0.3 -0.9
Number of children fathered 0.0 0.0 0.0 0.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 3.6 0.8 1.9
Age at first live birth 1.5 2.7 4.4 -1.0 2.1
Pulse wave peak to peak time 0.1 0.2 0.3 -0.5 0.1
Health satisfaction 3.2 4.2 6.0 -2.5 -1.6
Shortness of breath walking on level ground 0.4 0.4 0.9 0.9 -0.2
Qualifications: College or University degree 2.2 6.8 13.6 -0.1 3.7
Eye problems/disorders: None of the above 0.2 0.3 0.5 0.7 0.2
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.2 -0.6
Emphysema/chronic bronchitis 0.7 0.7 1.5 1.2 -0.1
Medication for pain relief, constipation, heartburn 1.0 1.8 2.8 -0.9 1.7
Neck or shoulder pain in last month 0.7 1.0 1.1 -1.1 -1.0
Medication: Blood pressure 2.3 4.1 7.9 -0.5 -2.8
Angina (self-reported) 0.4 0.5 0.8 -0.6 -0.9
Migraine (self-reported) 0.2 0.3 0.5 0.7 -0.2
Medication: Ibuprofen 0.3 0.3 0.6 0.2 -0.7
Medication: Allopurinol 0.3 0.4 0.4 -0.6 0.6
Medication: Omeprazole 1.2 1.4 2.2 -0.8 -1.5
Medication: Seretide 50 evohaler 1.9 2.2 3.8 -0.8 -1.9
Mean time to correctly identify matches 0.4 0.8 0.8 0.9 -0.9
Heart disease (mother) 0.0 0.0 0.0 0.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.5 -0.1 1.2
Whole body fat mass 0.4 1.8 3.3 0.6 -1.8
Leg fat mass (right) 0.5 2.1 3.1 1.0 -1.8
Arm predicted mass (right) 0.4 1.8 3.5 0.4 1.9
Pulse rate, automated reading 1.0 3.4 6.8 -0.1 -2.6
Alcohol intake frequency. 1.6 3.7 4.6 -1.6 -2.1
Comparative height size at age 10 0.0 0.1 0.1 -0.2 0.4
Number of full sisters 0.1 0.2 0.3 -0.6 -0.0
Suffer from ‘nerves’ 0.6 1.0 2.0 -1.4 -0.2
Overall health rating 1.5 3.2 4.0 -2.0 -1.5
Chest pain or discomfort 1.8 2.5 5.0 -2.2 -0.2
Had major operations 0.1 0.1 0.2 -0.1 -0.4
Age at last live birth 0.6 0.9 1.6 -1.3 0.5
Family relationship satisfaction 2.1 2.6 3.3 -1.8 -1.4
Leg pain on walking 1.1 1.4 2.5 -1.6 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 2.3 -1.5 -1.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 -0.3 -0.3
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 2.2 1.4 1.5
Medication: Aspirin 2.2 2.9 4.1 -1.3 -2.0
Supplements: Vitamin C 0.0 0.0 0.0 -0.0 0.0
Knee pain experienced in last month 1.4 2.1 3.4 -1.8 -0.9
Hypertension (Self-reported) 0.3 0.9 1.4 0.7 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.1 0.8 -1.1
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.0 0.5
Illnesses of siblings: Diabetes 0.8 1.0 1.8 -0.4 -1.3
Smoking status: Previous 0.2 0.3 0.6 -0.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 0.0 0.1
Whole body fat-free mass 0.3 1.5 2.8 0.5 1.7
Leg fat-free mass (right) 0.0 0.2 0.3 -0.4 0.6
Arm fat percentage (left) 0.9 3.6 6.4 0.9 -2.5
Average weekly red wine intake 0.7 1.1 1.9 0.5 1.4
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.6 0.8 -0.1
Mood swings 0.6 1.0 1.6 -0.7 1.3
Loneliness, isolation 1.5 2.0 3.5 0.7 -1.9
Long-standing illness, disability or infirmity 7.1 10.9 13.1 -3.6 -2.9
Ever had bowel cancer screening 2.2 2.5 5.0 0.0 -2.2
Diabetes diagnosed by doctor 0.3 0.5 0.7 -0.8 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 2.7 -0.8 -1.6
Friendships satisfaction 0.6 0.8 1.5 -1.2 0.1
Qualifications: nursing, teaching 0.7 1.0 1.1 -1.0 1.1
Commuting to job workplace: Walk 1.4 1.5 2.1 -1.5 -0.9
Eye problems/disorders: Cataract 2.7 3.1 4.3 -1.4 -2.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 -0.8 0.4
Medication for cholesterol 1.0 1.5 2.8 -1.7 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 1.8 -1.0 -1.3
Back pain experienced in last month 0.6 0.9 1.7 -1.3 0.0
Mineral and other dietary supplements 0.7 0.9 1.7 -1.3 -0.3
Breast cancer (self-reported) 0.5 0.6 1.2 0.1 1.1
Asthma (self-reported) 0.4 0.9 1.6 1.3 0.4
Osteoporosis (self-reported) 0.4 0.4 0.6 0.5 0.8
Osteoarthritis (self-reported) 2.8 3.6 4.0 -1.8 -2.0
Medication: Aspirin 1.0 1.3 2.1 -0.7 -1.5
Medication: Gliclazide 2.1 2.3 2.5 -1.5 -1.6
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.7 -0.2
Smoking status: Current 1.8 2.8 3.3 1.8 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.4 8.7 -2.9 0.3
Whole body water mass 0.3 1.5 2.9 0.3 1.7
Leg predicted mass (right) 0.0 0.2 0.2 -0.3 0.5
Arm fat mass (left) 0.3 1.3 1.9 0.9 -1.4
Number of self-reported non-cancer illnesses 0.4 0.8 1.5 -0.0 -1.2
Average weekly champagne plus white wine intake 2.9 4.0 4.3 1.9 2.1
Miserableness 0.5 0.9 1.7 -1.3 -0.2
Guilty feelings 0.1 0.1 0.2 0.1 0.4
Wears glasses or contact lenses 0.2 0.2 0.3 0.5 -0.4
Ever taken oral contraceptive pill 0.2 0.2 0.3 -0.3 0.6
Hearing aid user 3.2 3.7 4.0 1.8 -2.0
Mother’s age at death 0.4 0.5 0.8 -0.9 0.6
Financial situation satisfaction 3.0 3.7 4.1 -2.0 -1.8
Tinnitus: Yes, now most or all of the time 1.0 1.2 1.2 -1.1 -1.1
Commuting to job workplace: Public transport 1.2 1.4 2.1 0.8 1.5
Eye problems/disorders: Glaucoma 1.0 1.2 1.8 0.7 1.4
Medication: Blood pressure 0.8 1.4 2.6 1.6 0.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.3 -0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.3 1.1 -0.6
High cholesterol (Self-reported) 0.4 0.6 1.0 -1.0 -0.5
Medication: Bendroflumethiazide 1.7 2.6 4.1 2.0 -1.1
Medication: Paracetamol 0.3 0.4 0.8 0.9 -0.2
Medication: Lisinopril 0.2 0.2 0.3 0.3 -0.6
Medication: Atorvastatin 0.1 0.1 0.1 -0.3 -0.3
Illnesses of father: High blood pressure 1.0 1.2 1.7 0.8 1.3
Alcohol drinker status: Never 0.3 0.4 0.5 0.7 -0.5
Ever smoked 0.2 0.3 0.5 0.7 -0.2
Basal metabolic rate 0.2 0.9 1.6 0.4 1.3
Leg fat percentage (left) 1.2 4.4 6.4 2.5 -1.5
Arm fat-free mass (left) 0.3 1.6 2.6 0.8 1.6
Number of operations (self-reported) 0.6 1.0 1.5 -0.6 -1.2
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.8 -0.1
Irritability 0.1 0.2 0.4 0.6 0.1
Risk taking 1.7 2.5 3.0 -1.4 1.7
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 0.8 -0.2
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.4 0.3
Age started oral contraceptive pill 0.9 1.1 2.2 1.5 0.1
Diastolic blood pressure, automated reading 0.1 0.3 0.4 0.3 -0.7
Ever depressed for a whole week 0.6 0.8 1.5 1.2 0.3
Unable to work because of sickness or disability 1.8 2.4 4.5 -0.5 -2.1
Commuting to job workplace: Cycle 2.2 2.7 3.1 -1.8 1.5
Myopia 1.7 2.4 3.1 -1.4 -1.8
Vascular/heart problems diagnosed by doctor 0.7 1.9 2.8 -1.0 1.7
Cholesterol lowering medication 0.1 0.1 0.2 -0.4 0.1
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 2.4 -1.2 -1.5
Pain experienced in last month 0.9 1.5 2.9 0.4 1.7
Supplements: Calcium 0.6 0.7 1.2 1.1 0.4
Basal cell carcinoma (self-reported) 1.6 1.8 3.5 -1.9 0.4
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.7 -0.3 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.2 1.5 -0.2
Heart disease (siblings) 0.4 0.5 1.0 1.0 0.1
Alcohol drinker status: Previous 1.9 2.1 4.2 -0.3 -2.0
Pack years of smoking 0.1 0.1 0.2 0.1 -0.5
Impedance of whole body 0.4 1.8 2.6 -1.0 -1.6
Leg fat mass (left) 0.5 1.9 2.5 1.2 -1.6
Arm predicted mass (left) 0.4 1.9 3.3 0.7 1.8