Hub : Genes

RTN4RL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4310	0.0940	4.2e-06	0.142	NA	0.203	NA	0.301	1.8e-04	NA	6.4e-06	NA	1.9e-08
2	GTEx	Brain Cerebellum	0.3370	0.1040	6.7e-04	0.139	NA	0.202	NA	0.162	6.7e-05	NA	1.2e-06	NA	1.7e-05
3	GTEx	Colon Sigmoid	0.1740	0.0760	7.3e-03	0.002	NA	-0.007	NA	-0.003	2.7e-01	NA	6.6e-01	NA	4.2e-01
4	GTEx	Nerve Tibial	0.0787	0.0345	2.1e-03	0.013	NA	0.027	NA	0.018	4.1e-02	NA	4.8e-03	NA	1.9e-02
5	TCGA	Breast Invasive Carcinoma	0.0117	0.0079	7.4e-03	0.004	0.007	0.003	NA	0.003	4.6e-02	0.013	5.7e-02	NA	7.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	0.4	0.5	0.2	-0.1
Bipolar Disorder or Schizophrenia	2.3	5.5	8.6	-2.5	-2.7	-2.1	1.0	2.9
Depressed Affect (Nagel 2018)	2.9	6.1	14.0	-1.1	-2.2	-3.7	2.5	2.0
Depression (Nagel 2018)	2.9	4.4	6.7	-1.6	-2.3	-2.6	1.9	1.8
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.5	-0.2	-0.2	-0.0	0.2
Neuroticism (Nagel 2018)	3.6	8.5	17.1	-1.6	-2.5	-4.1	3.1	2.6
Schizophrenia (2018)	4.8	9.9	14.7	-3.1	-3.8	-3.1	1.0	3.8
Schizophrenia vs Biploar Disorder	1.8	2.4	3.3	-1.8	-1.7	-1.0	1.3	1.7
Worry (Nagel 2018)	1.6	3.4	8.1	-1.2	-1.5	-2.9	1.6	1.6
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	0.6	0.3	0.3	-0.9	-0.6
Alzheimer’s Disease (in father)	0.9	1.0	1.9	-0.6	-1.4	-1.3	0.5	1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-0.8	-1.0	-0.8	-0.6	0.6
Crohns Disease (2017)	0.1	0.2	0.6	0.1	0.2	-0.5	0.8	0.5
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.4	0.2	-0.4	-0.0	0.1
Ulcerative Colitis (UC)	0.1	0.3	0.7	0.1	-0.5	-0.6	-0.8	0.2
Major Depression (MDD)	2.9	3.5	17.1	-0.0	-0.3	-0.1	4.1	0.4
Reaction Time	0.5	0.9	2.0	-0.1	1.1	1.4	1.0	-0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	-0.2	-1.3	-0.7	1.3	1.2
Breast Cancer	1.3	3.2	4.8	2.0	2.2	0.8	-1.6	-2.1
Ovarian Cancer	1.1	1.4	2.2	1.0	1.3	1.1	1.5	-1.0
Prostate Cancer	0.4	0.5	2.3	-0.1	0.2	0.1	-1.5	-0.5
Age at First Birth	0.8	1.2	4.5	-0.9	-0.6	-0.4	-2.1	0.4
Bipolar Disorder (2011)	0.5	0.4	1.2	-1.1	-0.6	-0.8	-0.3	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	0.7	0.4	0.2	-0.5
Coronary Artery Disease (CAD)	1.5	1.8	2.6	-1.1	-0.9	-1.6	1.5	1.5
Crohns Disease (2012)	0.1	0.1	0.4	0.0	0.6	0.3	0.4	-0.1
Mean Putamen Volume	2.7	3.1	4.9	1.9	2.2	1.6	-0.6	-2.0
Fasting Glucose	1.0	1.2	2.4	0.6	0.9	1.4	-1.5	-0.8
HbA1C	3.7	4.1	10.2	1.4	1.4	3.2	-1.5	-2.0
HDL Cholesterol	0.7	1.2	3.9	0.2	0.8	2.0	-0.6	-0.9
LDL Cholesterol	0.6	0.9	1.7	1.1	0.6	1.0	1.3	-0.6
Lupus	0.3	0.5	1.6	0.4	0.3	0.8	1.3	-0.3
Neuroticism (2016)	0.8	1.2	4.7	0.3	0.0	-2.2	0.9	0.4
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.7	-0.1	0.6	0.3	0.4
Rheumatoid Arthritis	4.4	6.1	11.1	-2.3	-3.3	-2.5	-1.0	2.6
Schizophrenia (2014)	5.0	10.9	16.1	-3.3	-3.8	-3.5	1.1	4.0
Triglycerides	2.5	4.1	6.7	-2.2	-2.1	-2.6	0.3	2.1
Type 2 Diabetes (T2D) (2012)	4.8	5.6	8.4	2.3	2.7	1.8	-1.9	-2.9
Ulcerative Colitis	0.2	0.3	1.3	0.2	-0.3	-0.4	-1.1	0.2
Blood Eosinophil Count	1.3	9.6	17.3	3.4	4.2	2.3	-0.9	-3.7
Blood Platelet Count	2.1	24.1	63.8	1.9	5.1	8.0	2.5	-4.5
Blood Red Count	0.4	4.3	7.3	-2.2	-2.7	-1.8	1.0	2.3
Blood White Count	0.2	1.5	5.4	1.2	0.2	-2.3	0.6	-0.5
Heel T-Score	0.3	2.3	5.8	-2.4	-1.6	0.3	1.0	1.5
BMI	0.2	1.2	2.8	1.7	0.7	-0.4	0.4	-1.6
Height	0.5	8.9	22.2	2.9	1.4	2.6	-4.7	-2.2
Waist Hip Ratio (WHR)	1.3	5.8	13.8	3.7	2.0	0.4	-1.4	-3.0
Systolic Blood Pressure	0.4	1.9	5.1	1.0	0.6	-2.3	1.7	0.1
Smoking Status	0.8	1.8	4.1	2.0	0.3	1.6	-0.9	-1.1
Allergy or Eczema	0.1	0.2	0.6	0.3	0.3	-0.5	0.8	-0.3
Cardiovascular Disease	0.6	2.1	7.5	-0.1	-0.7	-2.7	1.3	1.0
Hypothyroidism (self reported)	4.4	10.0	15.7	-3.3	-4.0	-3.2	1.3	3.4
Respiratory disease	0.3	0.6	1.8	1.3	0.8	0.0	0.0	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	0.5	0.0	-1.2	0.4	0.2
Lung FEV1/FVC ratio	0.4	2.1	8.8	1.0	-0.0	0.2	-3.0	-0.8
Lung FVC	0.1	0.6	1.8	-0.4	0.7	1.4	0.4	-0.7
Neuroticism	2.7	6.6	15.5	-0.9	-1.8	-3.1	3.9	1.9
Chronotype (morning person)	1.6	3.7	5.6	2.4	2.0	0.7	-2.0	-2.0
Hair Pigment	0.0	0.5	1.1	1.0	0.7	-0.5	-0.0	-0.8
Tanning	0.1	1.3	5.2	-0.2	0.4	0.3	-2.3	-0.9
Hand grip strength (left)	1.0	2.5	12.2	-0.2	-0.5	0.0	-3.5	0.2
Number of treatments/medications taken	0.9	1.7	7.6	0.6	-0.6	-2.7	0.1	0.3
Average weekly spirits intake	0.2	0.2	0.4	-0.6	-0.4	0.5	0.1	0.2
Sensitivity / hurt feelings	0.8	1.4	3.4	0.0	-0.9	-1.6	1.9	0.7
Frequency of depressed mood in last 2 weeks	2.6	3.6	8.0	-1.2	-1.7	-2.8	1.9	1.5
Hearing difficulty/problems: Yes	1.5	2.3	4.4	-1.5	-1.1	-2.1	0.6	1.8
Relative age of first facial hair	0.1	0.3	0.6	-0.5	-0.4	0.8	0.7	-0.0
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.9	-1.3	-2.2	-1.6	0.3	1.9
Ever used hormone-replacement therapy (HRT)	3.5	4.5	5.3	-1.7	-2.3	-2.2	2.1	2.3
Ever had hysterectomy (womb removed)	3.5	3.9	5.7	-1.9	-2.4	-2.1	-0.5	2.3
Systolic blood pressure, automated reading	0.6	1.7	6.0	-0.6	-0.4	-2.5	1.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.3	0.5	-0.3	-0.3	-0.6	0.0
Angina	0.2	0.3	1.0	0.3	0.4	-1.0	0.2	-0.1
Medication for hormone replacement therapy	1.7	1.9	2.7	-1.2	-1.6	-1.1	1.2	1.6
Vitamin and mineral supplements	0.4	0.5	1.1	0.6	1.1	0.3	0.1	-0.9
Supplements: Zinc	0.9	1.0	2.5	1.3	0.6	0.5	-1.6	-0.5
Medication: Co-codamol	0.9	1.0	1.5	-1.0	-0.8	-1.2	1.0	1.1
Medication: Metformin	0.4	0.6	1.4	1.2	0.6	-0.9	0.4	-0.6
Diabetes (father)	2.1	2.7	7.8	-0.9	-1.5	-2.8	-0.3	1.5
Diabetes (mother)	0.3	0.4	1.0	-0.5	-1.0	-0.3	-0.4	0.7
Severe depression (siblings)	0.6	0.6	0.9	1.0	0.8	0.8	-0.0	-1.0
Pack years adult smoking proportion	0.4	0.7	2.9	0.2	0.3	0.5	1.7	-0.3
Impedance of leg (right)	0.0	0.1	0.3	-0.6	0.0	-0.1	-0.2	0.3
Leg fat-free mass (left)	0.1	0.5	1.7	1.3	0.0	0.3	-0.7	-0.6
Trunk fat percentage	0.2	0.6	1.9	0.2	-0.4	-1.4	1.1	-0.1
Hand grip strength (right)	0.6	1.6	6.7	-0.4	-0.7	-0.5	-2.6	0.6
Townsend deprivation index at recruitment	0.5	0.7	2.7	0.4	0.6	0.2	1.6	-0.3
Current tobacco smoking	0.1	0.1	0.3	0.5	-0.6	0.1	-0.3	0.0
Average weekly fortified wine intake	0.1	0.1	0.4	-0.1	-0.1	0.2	0.6	0.2
Maternal smoking around birth	0.4	0.6	1.6	-0.2	-0.3	-0.8	1.3	0.7
Fed-up feelings	5.2	9.5	15.2	-1.6	-2.8	-3.9	3.5	3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.5	-1.3	-1.9	-1.7	1.4	1.5
Relative age voice broke	0.3	0.5	1.1	0.3	0.5	1.1	-0.6	-0.7
Taking other prescription medications	0.7	1.1	2.1	1.4	0.7	-1.1	-0.9	-0.9
Age when periods started (menarche)	1.5	3.7	9.9	1.5	1.4	1.1	-3.1	-1.7
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	6.7	-1.4	-1.3	-2.6	0.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	5.0	-0.8	-0.7	-0.4	-2.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.9	-0.1	-0.1	-0.1	-2.0	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.5	0.4	-0.1	-0.6	0.7	0.0
Serious illness, injury or assault to yourself	0.7	0.9	2.0	0.1	-0.6	-1.4	-1.4	0.2
High blood pressure	2.1	6.0	16.2	-1.4	-1.8	-4.0	1.5	2.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.4	0.1	-0.6	0.0	-0.2
Multivitamins +/- minerals	0.9	1.2	2.1	-0.7	-1.4	-1.1	-0.8	1.2
Stomach or abdominal pain in last month	1.0	1.2	2.8	-0.2	-0.8	-1.7	1.2	1.1
Supplements: Glucosamine	0.7	0.9	1.7	0.8	0.9	1.3	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	0.2	-0.1	-0.3	0.8	0.2
Medication: Atenolol	1.1	1.4	3.2	1.8	1.1	0.3	0.5	-1.5
Medication: Levothyroxine sodium	3.3	5.5	8.6	-2.2	-2.6	-2.5	1.1	2.9
Sitting height	0.1	0.9	2.4	0.7	0.4	1.6	-1.3	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	0.4	-0.3	-0.9	-1.6	0.2
High blood pressure (mother)	0.8	1.1	3.5	-0.2	-0.3	-1.9	-1.4	0.2
Body mass index (BMI)	0.1	0.6	1.8	0.6	-0.3	-1.4	0.7	-0.4
Impedance of leg (left)	0.0	0.1	0.3	-0.5	-0.0	-0.3	-0.1	0.4
Leg predicted mass (left)	0.1	0.5	1.7	1.3	0.0	0.3	-0.7	-0.6
Trunk fat mass	0.1	0.5	1.6	0.5	-0.4	-1.3	0.4	-0.2
Waist circumference	0.5	1.8	4.9	2.2	0.5	-0.9	-0.7	-1.5
Number of incorrect matches in round	0.7	1.1	3.7	-0.7	-0.8	-1.9	0.3	0.8
Past tobacco smoking	0.1	0.2	0.7	-0.5	0.3	-0.8	-0.4	-0.2
Alcohol usually taken with meals	0.7	1.1	4.5	-0.2	0.6	0.8	-2.1	-0.3
Nervous feelings	1.6	3.0	6.5	-1.0	-1.3	-2.6	1.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	8.0	-1.3	-2.0	-2.8	2.1	1.7
Hearing difficulty/problems with background noise	1.2	2.0	3.1	-1.8	-1.2	-1.3	0.7	1.7
Hair/balding pattern: Pattern 2	2.2	2.8	13.5	0.2	-0.3	0.6	-3.7	-0.4
Had menopause	2.0	2.5	4.0	-1.7	-1.9	-1.0	1.1	2.0
Had other major operations	0.3	0.4	1.1	0.4	-0.5	0.4	-1.1	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	0.2	0.2	0.5	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.2	-0.4	-0.6	-0.7	-2.0	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.0	-0.4	-0.6	0.4	-0.1
Qualifications: None of the above	3.4	7.4	14.1	-2.8	-2.7	-3.8	0.9	2.7
Financial difficulties in last 2 years	0.3	0.3	1.4	-0.2	-0.4	0.0	1.2	-0.2
Mouth/teeth dental problems	0.1	0.2	0.4	-0.7	-0.4	0.3	0.3	0.4
Heart attack	1.6	2.0	4.4	2.1	1.6	0.7	0.4	-1.5
Allergy	0.1	0.2	0.5	-0.7	-0.5	0.1	-0.1	0.6
Pain all over the body in last month	0.8	0.8	1.7	-0.6	-0.7	-1.0	1.3	0.9
Diabetes (self-reported)	0.3	0.5	1.7	0.8	-0.1	-1.3	-0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.1	0.3	0.4	-0.2	1.1	-0.2
Medication: Ramipril	1.1	1.4	3.7	-0.5	-1.2	-1.9	-0.5	1.2
Medication: Simvastatin	0.4	0.6	1.7	-0.4	-0.7	-1.3	0.6	0.5
Fluid intelligence score	0.5	1.1	2.4	-0.3	-0.9	-0.9	1.5	1.1
Illnesses of siblings	0.8	1.2	4.6	0.1	0.6	0.9	-2.1	-0.4
Neuroticism score	3.4	7.0	15.3	-0.9	-2.1	-3.9	3.2	2.1
Weight	0.1	0.7	2.4	1.5	0.1	-0.5	-0.5	-0.9
Impedance of arm (right)	0.0	0.2	0.7	-0.6	0.3	0.8	-0.1	-0.1
Arm fat percentage (right)	0.1	0.5	2.0	0.1	-0.5	-1.4	0.5	-0.2
Trunk fat-free mass	0.2	1.3	3.5	1.5	0.1	0.6	-1.9	-0.6
Hip circumference	0.1	0.3	0.8	0.5	-0.4	-0.9	-0.6	0.0
Time employed in main current job	0.6	0.7	1.6	-1.3	-0.8	-0.4	-0.5	0.9
Alcohol intake versus 10 years previously	0.6	0.9	2.3	1.5	0.7	0.4	0.1	-1.2
Father’s age at death	0.4	0.6	1.4	0.3	0.4	1.1	-1.2	-0.4
Worrier / anxious feelings	3.4	6.4	14.2	-1.9	-2.0	-3.8	2.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.9	13.1	-1.3	-2.6	-3.6	1.5	2.4
Falls in the last year	0.5	0.7	1.8	0.6	0.7	0.0	-1.4	-0.8
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	0.4	0.4	0.0	-0.6
Number of live births	0.1	0.1	0.3	-0.1	-0.3	-0.6	0.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.8	0.6	0.1	0.1	-1.7	-0.6
Pulse rate	0.6	1.0	1.9	1.1	0.8	0.4	-1.4	-1.0
Happiness	1.4	1.7	2.5	-1.1	-1.3	-1.0	1.6	1.4
Noisy workplace	0.5	0.7	2.0	0.7	0.9	0.2	0.3	-1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.8	1.1	0.9	2.4	-0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.4	0.3	0.1	-0.9	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	1.1	0.0	-0.0	-0.2	1.1	0.0
Asthma	0.5	1.1	2.3	1.5	1.3	0.3	0.4	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	1.2	0.0	-0.4	-1.4	-0.6
Medication: Cholesterol lowering	0.3	0.5	0.8	0.9	0.6	-0.7	0.1	-0.8
Depression (self-reported)	4.2	5.0	8.1	-2.2	-2.4	-2.8	0.9	2.4
Medication: Lansoprazole	0.8	0.9	3.4	0.3	-0.3	-1.8	0.5	0.7
Prospective memory result	1.7	2.1	2.6	-1.6	-1.3	-1.5	1.3	1.5
Lung cancer (father)	0.7	0.8	0.9	1.0	0.8	0.9	-0.8	-1.0
Illnesses of mother	0.2	0.3	0.6	0.6	0.4	0.8	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.6	0.9	0.3	0.1	-1.9	-0.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.6	-0.4	0.3	-0.1	0.7
Impedance of arm (left)	0.0	0.1	0.3	-0.5	0.2	0.3	0.3	0.2
Arm fat mass (right)	0.1	0.6	2.3	0.3	-0.7	-1.5	0.2	0.1
Trunk predicted mass	0.2	1.2	3.2	1.5	0.0	0.6	-1.8	-0.6
Standing height	0.3	3.2	6.8	2.0	0.9	1.7	-2.6	-1.0
Length of working week for main job	1.4	1.6	2.6	1.6	1.6	1.1	0.3	-1.3
Exposure to tobacco smoke at home	1.7	1.9	3.5	-0.8	-0.9	-1.8	1.9	1.1
Breastfed as a baby	0.3	0.4	0.7	0.7	0.7	0.0	-0.8	-0.4
Tense / ‘highly strung’	0.4	0.6	1.7	-0.2	-0.4	-1.0	1.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.1	-0.3	-1.4	-1.8	0.0	0.8
Hair/balding pattern: Pattern 4	0.7	1.7	2.7	-1.0	-1.3	-0.9	1.6	1.4
Birth weight of first child	1.0	1.8	5.5	0.0	0.4	2.3	-1.6	-0.8
Peak expiratory flow (PEF)	0.2	0.5	2.3	0.5	-0.1	0.1	-1.5	-0.2
Pulse wave reflection index	0.9	1.1	1.7	-1.2	-1.1	-0.6	0.8	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	0.5	0.3	-0.2	-1.3	-0.7
Loud music exposure frequency	0.1	0.1	0.3	0.0	-0.1	-0.6	0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.3	0.4	0.7	1.8	-0.8	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	1.2	1.0	-0.0	-1.0	-1.0
Blood clot in the leg (DVT)	0.2	0.2	0.9	-0.9	-0.1	-0.0	0.3	0.5
Medication: Paracetamol	0.5	0.7	1.7	1.1	0.6	-0.5	-0.4	-1.3
Headache pain in last month	0.5	0.9	1.4	1.2	0.8	0.4	-1.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.5	-0.2	0.7	-0.3	0.2
Glaucoma (self-reported)	2.0	2.4	4.1	2.0	1.7	0.1	-1.6	-1.4
Gout (self-reported)	0.2	0.3	1.1	0.0	-0.3	-1.1	0.6	0.3
Hypothyroidism/myxoedema (self-reported)	3.7	7.1	11.0	-2.9	-3.3	-2.7	0.5	3.0
Medication: Amlodipine	3.0	4.2	7.2	-1.6	-2.1	-2.7	1.4	2.2
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.2	2.1	2.5	1.1	0.4	-1.9
Birth weight	1.0	2.1	7.2	0.4	0.3	1.5	-2.7	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.6	-0.5	-0.6	-0.3	1.3	0.6
High blood pressure (siblings)	0.4	0.5	2.0	0.4	0.1	-0.7	1.4	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	0.4	0.2	0.5	-0.8	-0.5
Body fat percentage	0.2	0.8	2.3	0.1	-0.5	-1.5	1.2	0.0
Leg fat percentage (right)	0.3	1.0	3.0	-0.2	-0.8	-1.7	1.1	0.2
Arm fat-free mass (right)	0.1	0.4	1.3	1.1	-0.3	-0.1	-0.6	-0.2
Exposure to tobacco smoke outside home	2.8	3.8	6.8	-1.8	-2.1	-2.6	-0.3	2.1
Comparative body size at age 10	0.9	2.4	4.1	-2.0	-1.8	-0.9	0.5	1.9
Number of full brothers	1.9	2.4	2.9	1.5	1.5	1.7	-1.3	-1.7
Worry too long after embarrassment	2.2	3.7	8.3	-1.3	-1.8	-2.9	1.5	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.7	-0.2	-0.3	-0.1	-0.3
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	1.8	0.5	-0.4	0.5	-0.8
Number of children fathered	1.2	1.3	1.9	1.3	1.4	0.8	1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.2	-0.9	-1.0	0.5	1.5	1.0
Age at first live birth	0.9	1.5	5.7	0.8	0.2	2.4	-0.8	-0.8
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	0.4	-0.2	0.1	-0.7
Health satisfaction	0.4	0.5	1.9	-0.2	-0.6	-1.4	-0.2	0.1
Shortness of breath walking on level ground	1.1	1.4	2.8	1.3	1.7	0.1	-0.1	-1.5
Qualifications: College or University degree	1.2	3.7	9.3	1.6	1.8	3.0	-0.9	-1.6
Eye problems/disorders: None of the above	0.2	0.3	1.1	-1.1	-0.1	0.2	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	7.8	9.3	13.0	-3.3	-3.0	-2.9	2.3	3.6
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.1	-0.7	0.1	-0.6	0.0
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	-1.4	-1.0	0.4	0.9	1.5
Neck or shoulder pain in last month	3.9	5.5	7.5	-2.3	-2.5	-2.7	1.5	2.4
Medication: Blood pressure	0.3	0.5	1.5	0.4	-0.0	-1.2	0.9	0.3
Angina (self-reported)	0.2	0.3	0.4	0.5	0.6	-0.7	0.1	-0.4
Migraine (self-reported)	2.6	3.3	5.8	1.3	1.8	1.5	-2.4	-1.7
Medication: Ibuprofen	0.7	0.8	2.2	1.2	0.2	-0.0	-1.5	-0.7
Medication: Allopurinol	0.8	1.1	1.8	-0.8	-0.7	-1.3	1.2	0.9
Medication: Omeprazole	0.9	1.1	1.9	1.4	1.3	0.0	-0.6	-1.2
Medication: Seretide 50 evohaler	0.6	0.7	2.7	-0.1	0.6	0.7	1.6	0.0
Mean time to correctly identify matches	0.2	0.4	1.7	-0.4	0.4	0.4	1.3	0.1
Heart disease (mother)	0.2	0.2	0.3	0.4	0.6	-0.1	-0.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	6.4	-2.5	-1.8	-1.4	-1.3	1.4
Whole body fat mass	0.1	0.5	1.5	0.6	-0.4	-1.2	0.5	-0.2
Leg fat mass (right)	0.1	0.5	1.9	0.3	-0.7	-1.4	0.5	0.1
Arm predicted mass (right)	0.1	0.4	1.4	1.2	-0.2	0.1	-0.5	-0.3
Pulse rate, automated reading	0.3	1.0	1.5	-1.2	-1.1	-0.1	0.8	1.2
Alcohol intake frequency.	0.3	0.6	1.7	0.5	0.8	0.1	1.3	-0.8
Comparative height size at age 10	0.0	0.1	0.1	0.3	-0.3	0.2	-0.3	0.2
Number of full sisters	1.1	1.4	2.0	1.2	1.3	1.4	-0.1	-1.3
Suffer from ‘nerves’	0.7	1.1	2.1	-1.2	-1.1	-1.5	-0.2	0.9
Overall health rating	2.7	5.8	8.9	-1.9	-2.6	-3.0	2.0	2.3
Chest pain or discomfort	2.4	3.5	6.9	2.6	1.1	-0.8	-2.3	-1.8
Had major operations	0.3	0.4	0.9	0.5	0.5	-0.5	-0.9	-0.6
Age at last live birth	0.7	1.0	3.0	0.9	0.3	1.7	0.8	-0.6
Family relationship satisfaction	0.1	0.2	0.7	0.0	-0.2	-0.2	0.8	-0.1
Leg pain on walking	0.8	1.0	1.4	1.0	0.7	1.0	-1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	-0.1	-0.2	-0.6	-0.1
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.7	1.0	1.0	1.3	-0.1	-1.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	-0.1	0.2	0.7	1.1	0.2
Medication: Aspirin	0.6	0.8	1.5	-1.0	-0.9	-1.2	0.3	0.8
Supplements: Vitamin C	0.4	0.4	1.5	0.3	-0.6	0.2	-1.2	-0.4
Knee pain experienced in last month	2.2	3.4	6.4	-1.5	-2.2	-2.5	-1.1	1.5
Hypertension (Self-reported)	2.3	6.5	16.6	-1.6	-1.9	-4.1	1.6	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	7.2	0.5	-1.1	-2.7	-0.5	1.1
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.4	-0.6	-1.0	0.3	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.2	0.4	-0.7	-1.1	-0.5	0.5
Smoking status: Previous	0.2	0.2	0.8	0.2	0.1	0.9	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	5.3	0.7	0.8	2.3	-2.2	-0.9
Whole body fat-free mass	0.1	0.8	2.1	1.5	0.1	0.5	-1.2	-0.6
Leg fat-free mass (right)	0.1	0.6	1.7	1.3	0.1	0.4	-0.8	-0.6
Arm fat percentage (left)	0.2	0.8	3.0	0.0	-0.7	-1.7	0.7	0.0
Average weekly red wine intake	0.6	0.9	4.0	-0.3	0.0	0.8	-2.0	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.1	0.5	0.0	-0.9	-0.4
Mood swings	0.8	1.5	5.8	0.4	-0.5	-2.4	1.0	0.3
Loneliness, isolation	3.1	4.3	6.4	-1.2	-2.0	-2.5	2.5	1.9
Long-standing illness, disability or infirmity	0.5	0.8	2.3	1.5	0.7	-0.1	-0.3	-1.1
Ever had bowel cancer screening	1.6	1.9	3.8	1.4	2.0	0.9	0.1	-1.6
Diabetes diagnosed by doctor	0.7	1.2	3.7	0.2	-0.7	-1.9	1.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.7	-0.7	-0.2	0.4	0.8
Friendships satisfaction	1.1	1.4	5.5	-0.1	-0.8	-0.7	2.4	0.6
Qualifications: nursing, teaching	0.8	1.2	4.5	2.1	0.5	0.3	-0.4	-1.0
Commuting to job workplace: Walk	1.2	1.3	2.3	-1.3	-1.1	-1.1	0.5	1.5
Eye problems/disorders: Cataract	0.7	0.8	2.7	-0.8	-0.6	-0.0	1.6	0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.5	1.4	1.3	0.5	-1.6	-1.5
Medication for cholesterol	1.6	2.4	5.9	0.8	1.6	2.4	-1.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.9	-1.4	-0.9	-0.5	-0.6	0.9
Back pain experienced in last month	0.9	1.3	2.3	-0.8	-1.4	-1.5	-0.5	1.1
Mineral and other dietary supplements	1.0	1.4	1.9	-1.2	-1.4	-0.7	1.2	1.3
Breast cancer (self-reported)	0.1	0.1	0.4	0.0	-0.1	-0.6	-0.5	-0.1
Asthma (self-reported)	0.7	1.3	3.0	1.7	1.4	0.2	0.4	-1.1
Osteoporosis (self-reported)	4.0	5.0	7.3	-2.0	-2.2	-1.6	2.7	2.5
Osteoarthritis (self-reported)	0.9	1.1	2.7	-1.1	-1.6	-0.7	-0.7	0.9
Medication: Aspirin	0.3	0.4	0.7	-0.7	-0.6	-0.8	-0.0	0.6
Medication: Gliclazide	0.4	0.5	1.6	0.4	-0.2	-0.7	1.3	-0.1
Illnesses of father: None of the above (group 1)	4.1	5.1	9.8	2.1	2.2	3.1	-0.3	-2.5
Smoking status: Current	0.1	0.2	0.7	0.4	-0.8	-0.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.5	1.1	1.4	1.0	-1.1	-1.9
Whole body water mass	0.1	0.7	1.8	1.3	-0.0	0.4	-1.1	-0.5
Leg predicted mass (right)	0.1	0.6	1.9	1.4	0.1	0.4	-0.8	-0.6
Arm fat mass (left)	0.1	0.6	2.3	0.5	-0.7	-1.5	0.3	-0.0
Number of self-reported non-cancer illnesses	1.9	3.2	9.3	-0.9	-1.8	-3.0	0.4	1.7
Average weekly champagne plus white wine intake	0.6	0.9	1.2	0.9	1.1	1.0	0.7	-0.9
Miserableness	0.7	1.2	4.0	-0.1	-0.7	-2.0	1.1	0.7
Guilty feelings	0.9	1.4	3.3	1.1	-0.2	-1.8	1.5	0.2
Wears glasses or contact lenses	0.4	0.4	1.7	-0.6	-0.2	-0.1	-1.3	0.3
Ever taken oral contraceptive pill	0.4	0.4	1.3	1.1	-0.4	-0.2	-0.6	-0.3
Hearing aid user	0.5	0.6	1.4	0.9	0.8	-0.2	-1.2	-0.3
Mother’s age at death	0.3	0.4	1.5	-0.4	0.2	0.4	-1.2	-0.1
Financial situation satisfaction	0.4	0.5	1.1	0.6	0.4	-0.0	1.1	-0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.7	0.0	0.5	0.1	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.5	-0.3	-0.5	-0.2	0.8
Eye problems/disorders: Glaucoma	2.8	3.3	6.3	2.5	2.1	0.9	-1.5	-1.6
Medication: Blood pressure	0.7	1.2	4.1	-0.3	-0.8	-2.0	0.7	0.9
Pain type(s) experienced in last month: Hip pain	2.1	2.7	3.4	-1.4	-1.9	-1.7	1.5	1.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.3	1.2	1.7	0.7	-1.8	-1.7
High cholesterol (Self-reported)	1.0	1.8	3.9	-1.2	-1.2	-2.0	0.7	1.2
Medication: Bendroflumethiazide	1.2	1.8	4.3	-0.8	-1.2	-2.1	1.1	1.1
Medication: Paracetamol	0.1	0.2	0.8	0.3	0.2	-0.9	-0.3	-0.3
Medication: Lisinopril	0.3	0.4	1.1	0.1	0.3	0.7	-1.1	-0.4
Medication: Atorvastatin	0.7	0.9	1.9	1.4	0.7	-0.4	0.4	-1.3
Illnesses of father: High blood pressure	1.3	1.6	3.2	-1.5	-1.2	-1.8	0.0	1.1
Alcohol drinker status: Never	0.1	0.1	0.2	0.5	0.4	-0.4	-0.3	-0.2
Ever smoked	0.2	0.3	0.9	0.5	-0.6	0.9	0.0	0.2
Basal metabolic rate	0.1	0.8	2.2	1.5	0.0	0.1	-1.1	-0.6
Leg fat percentage (left)	0.3	1.2	4.0	-0.2	-0.9	-2.0	1.1	0.3
Arm fat-free mass (left)	0.1	0.4	1.2	1.1	-0.2	0.0	-0.9	-0.3
Number of operations (self-reported)	2.0	3.0	4.6	1.7	1.8	1.0	-2.1	-1.8
Average weekly beer plus cider intake	0.7	1.0	1.5	-0.9	-0.9	-1.2	-1.2	0.6
Irritability	0.5	0.8	2.0	0.6	0.1	-1.4	1.2	0.1
Risk taking	3.1	4.6	6.5	2.5	1.8	1.0	-2.6	-2.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	0.3	-0.0	0.7	0.2	-0.0
Fractured/broken bones in last 5 years	0.6	0.8	1.5	1.2	0.9	0.3	-0.1	-1.2
Age started oral contraceptive pill	1.6	2.0	3.9	1.4	1.3	2.0	-0.4	-1.4
Diastolic blood pressure, automated reading	0.9	2.8	8.1	-1.1	-1.2	-2.9	1.3	1.4
Ever depressed for a whole week	0.6	0.7	1.5	-0.5	-0.8	-1.2	0.8	0.7
Unable to work because of sickness or disability	2.5	3.3	5.1	-2.0	-2.3	-1.5	0.6	2.1
Commuting to job workplace: Cycle	1.1	1.3	1.8	-1.3	-1.3	-1.2	-0.4	1.3
Myopia	0.1	0.1	0.2	-0.1	-0.4	-0.2	0.5	0.4
Vascular/heart problems diagnosed by doctor	1.2	3.4	10.5	0.7	1.0	3.2	-1.6	-1.6
Cholesterol lowering medication	0.6	0.8	1.9	-0.6	-0.9	-1.4	0.9	0.6
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.9	1.4	1.2	-0.5	-0.1	-1.0
Pain experienced in last month	3.1	5.2	7.7	2.4	2.6	2.8	-0.4	-2.3
Supplements: Calcium	1.0	1.1	2.0	-0.8	-0.8	-0.9	1.2	1.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.5	0.2	0.9	-1.1	-0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.1	1.8	1.4	0.6	0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.6	0.3	0.3	0.0	0.0
Heart disease (siblings)	0.4	0.5	2.4	0.0	-0.1	-0.5	1.5	0.2
Alcohol drinker status: Previous	1.9	2.1	3.0	1.3	1.4	1.7	1.2	-1.7
Pack years of smoking	0.3	0.5	2.1	0.1	0.2	0.2	1.4	-0.3
Impedance of whole body	0.0	0.1	0.3	-0.3	0.5	0.5	0.2	-0.0
Leg fat mass (left)	0.1	0.5	1.8	0.4	-0.6	-1.4	0.5	-0.0
Arm predicted mass (left)	0.1	0.3	0.6	0.8	-0.6	-0.3	-0.6	0.1