Hub : Genes

RUFY2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1240	0.0350	1.9e-08	0.144	NA	0.136	NA	0.126	6.2e-11	NA	2.1e-10	NA	1.0e-09
2	GTEx	Esophagus Muscularis	0.0580	0.0290	6.4e-03	0.018	NA	0.020	NA	0.021	2.7e-02	NA	2.2e-02	NA	2.0e-02
3	GTEx	Muscle Skeletal	0.0758	0.0308	4.3e-04	0.046	NA	0.034	NA	0.034	2.4e-05	NA	2.5e-04	NA	2.6e-04
4	GTEx	Skin Sun Exposed Lower leg	0.0500	0.0250	6.0e-03	0.062	NA	0.039	NA	0.041	7.9e-06	NA	3.6e-04	NA	2.5e-04
5	METSIM	Adipose	0.0864	0.0280	3.0e-10	0.085	0.061	0.061	0.064	0.079	1.0e-12	1.8e-09	1.9e-09	7.1e-10	6.2e-12
6	ROSMAP	Brain Pre-frontal Cortex	0.0522	0.0226	4.6e-04	0.040	0.024	0.040	0.034	0.039	6.6e-06	3.5e-04	6.9e-06	2.6e-05	7.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	1.9	-1.4	-1.3	-1.1	1.2	-0.8	-1.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.5	0.0	-0.7	0.0	0.0	0.3	-0.1
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.1	0.4	-0.2	-0.0	0.3
Depression (Nagel 2018)	1.5	2.2	4.2	1.4	2.1	1.4	-1.3	1.0	1.5
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.4	-1.3	-2.1	-1.3	1.6	-1.0	-1.7
Neuroticism (Nagel 2018)	1.2	2.8	4.1	1.3	1.1	2.0	-1.8	2.0	1.7
Schizophrenia (2018)	0.4	0.7	1.2	1.1	0.1	0.9	-0.9	1.0	0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.3	-0.1	-0.8	0.6	-0.7	-0.4
Worry (Nagel 2018)	3.5	7.4	10.2	2.4	2.2	2.9	-2.9	3.2	2.7
Alzheimer’s Disease (in mother)	1.8	2.1	2.7	1.3	1.4	1.6	-1.6	1.2	1.6
Alzheimer’s Disease (in father)	1.0	1.1	1.7	0.7	0.8	1.3	-1.1	1.0	1.1
Alzheimer’s Disease (including proxy)	2.0	2.9	4.1	1.4	1.4	2.0	-1.8	1.5	1.9
Crohns Disease (2017)	0.1	0.1	0.3	-0.5	-0.5	-0.0	0.1	-0.2	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.5	-0.9	-0.2	0.3	-0.0	-0.5
Ulcerative Colitis (UC)	0.1	0.1	0.6	-0.2	-0.8	-0.2	0.2	-0.1	-0.3
Major Depression (MDD)	0.4	0.5	0.9	-0.7	-0.2	-0.8	0.8	-0.7	-0.9
Reaction Time	4.3	8.2	9.7	2.8	3.1	2.9	-2.7	3.1	2.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.4	-0.6	-1.2	-0.6	0.7	0.1	-1.0
Breast Cancer	1.6	3.9	4.8	2.0	2.2	1.9	-1.8	2.0	1.8
Ovarian Cancer	0.0	0.0	0.2	0.1	0.4	0.2	0.0	0.2	0.1
Prostate Cancer	0.1	0.2	0.4	-0.6	-0.5	-0.2	0.3	-0.6	-0.1
Age at First Birth	0.9	1.4	1.8	1.3	0.9	1.1	-1.2	1.3	1.2
Bipolar Disorder (2011)	1.3	1.2	1.9	-1.4	-1.4	-0.9	0.9	-1.0	-1.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.1	-0.4	0.4	-0.2	-0.5
Coronary Artery Disease (CAD)	0.2	0.3	0.4	0.2	0.6	0.6	-0.6	0.3	0.6
Crohns Disease (2012)	0.1	0.1	0.2	-0.1	-0.3	0.4	-0.5	0.4	0.2
Mean Putamen Volume	0.1	0.2	0.5	-0.3	0.3	-0.3	0.4	-0.7	-0.2
Fasting Glucose	1.9	2.2	2.8	-1.7	-1.3	-1.2	1.6	-1.5	-1.6
HbA1C	0.2	0.2	0.5	-0.5	-0.4	-0.7	0.4	-0.4	-0.5
HDL Cholesterol	2.2	3.7	4.6	2.1	1.9	1.8	-1.9	1.8	2.0
LDL Cholesterol	0.7	1.1	2.1	-0.9	-0.2	-1.1	1.1	-1.4	-1.0
Lupus	2.0	3.1	4.3	1.9	1.0	1.8	-1.9	2.1	1.7
Neuroticism (2016)	0.9	1.3	2.2	1.1	0.9	1.5	-1.1	1.1	1.0
Primary Biliary Cirrhosis	1.7	2.4	2.8	-1.6	-1.4	-1.5	1.5	-1.7	-1.6
Rheumatoid Arthritis	0.1	0.2	0.5	-0.6	-0.7	-0.3	0.2	-0.1	-0.4
Schizophrenia (2014)	0.0	0.1	0.1	0.2	-0.2	0.2	-0.2	0.2	0.3
Triglycerides	0.3	0.4	0.6	-0.8	-0.7	-0.5	0.6	-0.7	-0.7
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.5	-1.0	-1.0	-1.1	1.2	-1.2	-1.1
Ulcerative Colitis	0.0	0.0	0.1	-0.2	0.0	-0.3	0.1	0.2	-0.3
Blood Eosinophil Count	1.7	13.5	17.4	3.5	3.1	4.2	-3.8	3.7	3.7
Blood Platelet Count	0.0	0.1	0.4	-0.1	0.2	-0.5	0.2	-0.6	-0.1
Blood Red Count	0.4	3.9	5.3	-2.3	-2.3	-1.5	1.9	-1.7	-2.0
Blood White Count	0.0	0.0	0.2	-0.1	-0.4	-0.2	0.0	-0.1	0.2
Heel T-Score	1.4	11.5	13.2	-3.0	-3.3	-3.6	3.5	-3.5	-3.4
BMI	0.9	4.9	7.2	-2.3	-1.0	-2.4	2.4	-2.7	-2.2
Height	5.8	111.9	134.6	-10.1	-11.6	-10.1	10.6	-10.6	-10.4
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	0.3	0.1
Systolic Blood Pressure	0.5	2.4	4.0	1.5	2.0	1.4	-1.5	1.3	1.5
Smoking Status	0.8	2.0	5.7	1.3	2.4	1.1	-1.1	0.9	1.2
Allergy or Eczema	0.9	2.3	3.4	1.7	1.8	1.2	-1.4	1.8	1.2
Cardiovascular Disease	0.6	2.0	3.0	1.4	1.7	1.6	-1.3	1.1	1.3
Hypothyroidism (self reported)	0.3	0.7	1.2	0.8	1.1	0.7	-0.9	0.6	0.9
Respiratory disease	2.5	5.6	6.7	2.6	2.5	2.2	-2.3	2.3	2.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.8	-0.6	-0.3	0.1	-0.2	-0.2
Lung FEV1/FVC ratio	1.2	5.8	6.2	-2.5	-2.2	-2.4	2.5	-2.5	-2.4
Lung FVC	3.4	17.3	33.4	3.6	5.8	3.7	-3.8	4.0	3.7
Neuroticism	0.3	0.8	1.3	0.5	0.4	1.1	-1.0	1.1	0.9
Chronotype (morning person)	0.3	0.6	1.3	0.7	0.4	1.2	-0.8	0.7	0.8
Hair Pigment	0.1	1.4	1.9	1.0	1.4	1.1	-1.2	1.0	1.3
Tanning	0.1	1.6	2.1	1.2	0.9	1.2	-1.4	1.3	1.4
Hand grip strength (left)	0.4	1.0	1.4	-0.7	-1.2	-1.0	0.9	-1.2	-0.7
Number of treatments/medications taken	0.9	1.5	6.0	0.9	2.5	0.8	-0.8	0.5	0.9
Average weekly spirits intake	0.1	0.2	0.6	-0.2	-0.8	-0.1	-0.1	0.6	-0.2
Sensitivity / hurt feelings	3.4	5.8	7.1	2.4	1.4	2.5	-2.6	2.7	2.6
Frequency of depressed mood in last 2 weeks	1.5	2.2	4.2	1.4	2.1	1.3	-1.3	1.0	1.5
Hearing difficulty/problems: Yes	1.3	2.0	2.3	1.4	1.4	1.4	-1.5	1.4	1.5
Relative age of first facial hair	0.0	0.1	0.1	0.2	-0.4	0.2	-0.2	0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	1.0	1.1	0.9	-0.8	0.6	0.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	-1.2	-0.3	-0.7	0.7	-0.5	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	-1.0	-0.4	-0.7	1.1	-0.9	-1.2
Systolic blood pressure, automated reading	0.1	0.3	1.4	0.4	1.2	0.1	-0.2	0.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	0.5	0.1	-0.2	-0.2	0.2
Angina	0.3	0.3	1.8	-0.3	1.4	-0.1	0.0	-0.2	-0.0
Medication for hormone replacement therapy	0.5	0.5	0.9	-0.9	-0.9	-0.5	0.5	-0.9	-0.5
Vitamin and mineral supplements	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.1	-0.2	0.1
Supplements: Zinc	0.1	0.1	0.3	0.1	-0.5	-0.2	0.0	0.5	-0.2
Medication: Co-codamol	1.0	1.1	2.2	-1.2	-0.3	-1.1	1.0	-1.5	-0.9
Medication: Metformin	0.2	0.2	0.5	-0.5	-0.2	-0.6	0.4	-0.7	-0.3
Diabetes (father)	0.6	0.7	1.3	-1.1	-0.5	-0.9	0.8	-0.9	-0.8
Diabetes (mother)	0.6	0.8	1.7	-0.9	-0.2	-0.8	1.0	-1.3	-0.8
Severe depression (siblings)	0.1	0.1	0.4	-0.1	-0.6	-0.3	0.3	-0.4	-0.2
Pack years adult smoking proportion	2.1	3.2	3.9	1.5	1.7	1.9	-1.7	2.0	1.8
Impedance of leg (right)	0.1	0.4	0.6	0.2	0.8	0.4	-0.7	0.7	0.6
Leg fat-free mass (left)	2.5	13.5	17.3	-3.5	-4.2	-3.2	3.7	-3.9	-3.5
Trunk fat percentage	0.8	3.2	5.0	-2.2	-1.0	-1.8	1.7	-2.2	-1.6
Hand grip strength (right)	0.7	2.0	2.7	-1.2	-1.6	-1.5	1.3	-1.5	-1.2
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.0	-0.3	0.1	-0.2	-0.1	0.2
Current tobacco smoking	0.2	0.4	0.8	0.4	0.9	0.4	-0.5	0.6	0.6
Average weekly fortified wine intake	0.2	0.3	0.5	0.2	-0.4	0.6	-0.7	0.5	0.6
Maternal smoking around birth	0.1	0.2	0.9	-0.2	-1.0	0.3	-0.3	0.1	0.2
Fed-up feelings	0.1	0.2	0.4	-0.6	-0.4	-0.4	0.4	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.6	1.3	1.6	1.1	-1.2	1.0	1.3
Relative age voice broke	0.1	0.2	0.6	0.3	-0.2	0.4	-0.5	0.8	0.4
Taking other prescription medications	3.8	5.8	8.0	2.2	2.8	2.5	-2.4	2.0	2.5
Age when periods started (menarche)	5.4	13.1	16.0	3.5	2.3	4.0	-3.9	3.7	3.9
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.3	0.6	-0.1	0.3	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	2.2	-1.2	-1.5	-1.5	1.4	-1.2	-1.5
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1	0.0	-0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	-0.3	-0.1
Serious illness, injury or assault to yourself	1.9	2.3	2.8	-1.6	-1.7	-1.3	1.6	-1.3	-1.6
High blood pressure	0.5	1.4	2.2	1.1	1.3	1.5	-1.0	0.8	1.1
Hayfever, allergic rhinitis or eczema	1.2	2.5	4.2	1.8	2.0	1.2	-1.3	1.8	1.2
Multivitamins +/- minerals	0.1	0.1	0.3	0.5	0.6	-0.1	0.1	0.1	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.1	0.7	-0.0	0.0	-0.3	0.1
Supplements: Glucosamine	0.0	0.0	0.1	-0.0	0.1	-0.3	0.1	-0.3	0.0
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	6.1	-2.0	-2.5	-1.8	1.7	-2.1	-1.5
Medication: Atenolol	0.3	0.4	0.8	0.5	0.7	0.6	-0.7	0.1	0.9
Medication: Levothyroxine sodium	0.3	0.6	0.9	0.8	1.0	0.5	-0.8	0.5	0.8
Sitting height	10.4	73.8	97.4	-8.4	-9.9	-7.9	8.4	-8.6	-8.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.1	0.7	0.6	-0.5	0.3	0.5
High blood pressure (mother)	0.0	0.0	0.1	0.0	0.3	-0.2	0.1	-0.1	-0.2
Body mass index (BMI)	0.4	1.6	3.0	-1.4	-0.1	-1.3	1.3	-1.7	-1.1
Impedance of leg (left)	0.1	0.3	0.9	0.1	0.9	0.3	-0.6	0.6	0.5
Leg predicted mass (left)	2.6	13.8	17.2	-3.5	-4.1	-3.3	3.7	-4.0	-3.6
Trunk fat mass	2.1	9.1	12.4	-3.4	-2.3	-2.9	3.0	-3.5	-2.8
Waist circumference	1.8	6.5	9.9	-2.8	-1.6	-2.5	2.6	-3.1	-2.4
Number of incorrect matches in round	0.2	0.4	1.8	0.5	1.3	-0.2	0.1	-0.1	-0.2
Past tobacco smoking	0.1	0.2	0.4	0.2	-0.6	0.1	-0.2	0.6	0.2
Alcohol usually taken with meals	1.1	1.8	3.1	1.3	0.5	1.4	-1.4	1.8	1.3
Nervous feelings	3.7	6.8	7.7	2.4	2.7	2.6	-2.6	2.8	2.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.4	0.9	0.5	-0.7	0.6	0.7
Hearing difficulty/problems with background noise	0.9	1.5	1.6	1.2	1.2	1.1	-1.2	1.3	1.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.6	-0.4	-0.8	-0.1	0.1	0.1	-0.3
Had menopause	0.1	0.1	0.2	-0.3	0.2	0.1	-0.3	0.5	0.0
Had other major operations	0.1	0.2	0.4	-0.6	-0.2	-0.1	0.3	-0.7	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.1	-0.4	-0.0	-0.0	0.2	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	2.2	-1.2	-1.4	-1.3	1.4	-1.1	-1.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.4	-1.1	-0.8	-1.1	1.2	-1.0	-1.1
Qualifications: None of the above	0.4	0.8	1.1	0.6	1.0	0.8	-1.1	0.6	1.1
Financial difficulties in last 2 years	0.2	0.2	0.8	-0.4	-0.9	-0.1	0.3	-0.4	-0.1
Mouth/teeth dental problems	0.3	0.4	1.9	0.0	-1.4	-0.3	0.4	-0.1	-0.4
Heart attack	5.2	6.7	8.4	-2.7	-2.9	-2.6	2.4	-2.4	-2.5
Allergy	1.4	3.3	5.6	-1.9	-2.4	-1.6	1.6	-1.8	-1.6
Pain all over the body in last month	0.9	1.0	1.5	1.2	1.0	0.9	-0.9	0.7	1.1
Diabetes (self-reported)	0.5	0.7	1.4	-1.2	-1.2	-0.6	0.6	-0.8	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.0	0.2	-0.2	0.4	-0.1	-0.4
Medication: Ramipril	0.3	0.4	0.8	0.6	0.1	0.9	-0.7	0.3	0.7
Medication: Simvastatin	0.3	0.4	0.6	0.2	0.7	0.8	-0.7	0.6	0.7
Fluid intelligence score	0.3	0.6	1.8	-0.5	-1.3	-0.7	0.7	-0.3	-0.8
Illnesses of siblings	1.1	1.6	2.0	-1.0	-0.9	-1.3	1.4	-1.4	-1.4
Neuroticism score	1.9	4.0	4.7	1.7	1.5	2.2	-2.2	2.2	2.1
Weight	3.0	14.8	19.5	-3.9	-3.4	-3.7	3.9	-4.4	-3.7
Impedance of arm (right)	0.5	2.2	2.8	1.3	0.9	1.5	-1.7	1.6	1.7
Arm fat percentage (right)	0.4	1.7	3.4	-1.6	-0.1	-1.4	1.2	-1.8	-1.0
Trunk fat-free mass	3.7	21.1	24.6	-4.3	-5.0	-4.2	4.7	-4.8	-4.6
Hip circumference	1.8	7.7	12.8	-2.8	-2.1	-2.7	2.7	-3.6	-2.5
Time employed in main current job	3.3	3.8	5.0	2.0	1.9	1.9	-1.9	2.2	1.8
Alcohol intake versus 10 years previously	1.0	1.5	3.1	-1.0	-0.5	-1.2	1.3	-1.8	-1.2
Father’s age at death	3.2	4.3	5.5	1.9	1.7	2.1	-2.2	2.3	2.1
Worrier / anxious feelings	3.1	5.9	6.4	2.3	2.4	2.3	-2.5	2.5	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	1.2	1.0	0.9	-1.0	0.7	1.2
Falls in the last year	0.2	0.2	0.4	0.2	-0.6	0.6	-0.5	0.2	0.5
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.1	-0.2	-0.5	0.5	-0.9	-0.4
Number of live births	1.0	1.4	2.2	1.0	1.0	1.5	-1.3	0.8	1.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.4	-1.2	-0.7	-0.9	1.0	-1.0	-1.0
Pulse rate	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1	-0.3	-0.1
Happiness	0.7	0.8	1.2	-0.8	0.1	-1.0	1.0	-1.1	-1.1
Noisy workplace	0.9	1.1	1.7	-1.3	0.4	-1.3	1.0	-1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.5	-0.6	-0.6	0.9	-0.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.4	1.2	0.7	1.1	-1.0	1.1	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	1.6	1.1	1.3	1.1	-1.2	1.1	1.1
Asthma	5.4	10.6	11.8	3.4	3.1	3.3	-3.3	3.0	3.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.1	-0.5	0.0	-0.9	1.0	-0.9	-1.0
Medication: Cholesterol lowering	0.7	1.1	1.5	0.8	1.2	0.9	-1.0	1.2	1.0
Depression (self-reported)	0.2	0.2	0.5	0.2	0.7	0.6	-0.3	0.3	0.3
Medication: Lansoprazole	4.9	5.6	7.2	2.1	2.7	2.4	-2.4	2.1	2.5
Prospective memory result	0.4	0.5	1.4	0.8	1.2	0.5	-0.5	0.7	0.3
Lung cancer (father)	0.1	0.1	0.2	-0.2	0.4	-0.3	0.3	-0.5	-0.2
Illnesses of mother	1.4	1.8	2.3	-1.3	-1.5	-1.2	1.4	-1.0	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.1	0.5	0.1	-0.2	0.1	0.2
Pulse wave Arterial Stiffness index	0.8	0.9	1.3	-1.1	-1.0	-0.7	1.0	-0.6	-1.1
Impedance of arm (left)	0.4	1.8	2.5	1.1	0.8	1.3	-1.6	1.5	1.5
Arm fat mass (right)	1.5	6.0	9.0	-2.7	-1.6	-2.4	2.5	-3.0	-2.3
Trunk predicted mass	3.6	20.8	24.2	-4.3	-4.9	-4.2	4.7	-4.7	-4.5
Standing height	3.8	37.6	55.4	-5.7	-7.4	-5.5	6.0	-6.0	-5.9
Length of working week for main job	0.2	0.2	0.3	0.4	0.5	0.5	-0.5	0.6	0.5
Exposure to tobacco smoke at home	2.3	2.6	3.6	1.4	1.6	1.9	-1.7	1.4	1.7
Breastfed as a baby	1.4	1.7	2.2	-1.5	-1.4	-1.3	1.2	-1.3	-1.2
Tense / ‘highly strung’	2.5	4.1	6.6	1.8	1.1	2.2	-2.2	2.6	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.0	-0.1	0.3	-0.1	0.3	0.0
Hair/balding pattern: Pattern 4	0.4	1.0	1.9	-0.9	-0.7	-1.4	1.0	-0.8	-1.1
Birth weight of first child	0.5	1.0	1.2	1.0	0.8	1.0	-1.0	1.1	1.1
Peak expiratory flow (PEF)	1.0	2.4	3.3	-1.8	-1.3	-1.6	1.5	-1.7	-1.5
Pulse wave reflection index	0.1	0.1	0.2	-0.3	0.1	0.0	0.3	0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.3	-0.2	-0.2
Loud music exposure frequency	0.1	0.1	0.4	-0.2	-0.6	-0.2	-0.0	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	2.3	-1.4	-1.5	-0.9	1.3	-1.2	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-1.1	-0.4	-0.7	0.8	-0.9	-0.8
Blood clot in the leg (DVT)	0.4	0.5	2.0	-0.8	-1.4	-0.3	0.2	-0.4	-0.2
Medication: Paracetamol	0.1	0.2	0.3	-0.5	0.2	-0.3	0.5	-0.2	-0.5
Headache pain in last month	0.1	0.1	0.5	0.2	0.7	-0.2	0.2	-0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.3	-0.5	-0.5	0.2	-0.5	-0.3
Glaucoma (self-reported)	0.2	0.2	0.5	0.4	-0.3	0.4	-0.4	0.7	0.4
Gout (self-reported)	0.5	0.6	1.6	0.6	1.3	0.5	-0.8	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.4	0.8	0.6	-0.6	0.4	0.7
Medication: Amlodipine	0.5	0.7	1.1	-1.0	-0.8	-0.8	0.9	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	6.1	7.8	9.2	2.6	2.5	3.0	-2.9	2.7	2.9
Birth weight	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.4	-0.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.3	-0.5	0.3	-0.5	0.6	0.5
High blood pressure (siblings)	1.6	2.3	3.9	1.6	2.0	1.3	-1.4	1.4	1.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	0.5	1.0	0.5	-0.6	0.5	0.6
Body fat percentage	1.0	4.0	6.4	-2.5	-0.7	-2.0	1.9	-2.5	-1.8
Leg fat percentage (right)	0.9	3.3	5.5	-2.3	-0.0	-2.0	1.7	-2.3	-1.5
Arm fat-free mass (right)	3.7	19.1	20.6	-4.2	-4.5	-4.0	4.5	-4.5	-4.4
Exposure to tobacco smoke outside home	1.1	1.5	1.7	-1.3	-1.3	-1.3	1.2	-0.8	-1.3
Comparative body size at age 10	0.3	0.7	1.3	-0.8	-0.1	-0.8	1.0	-0.7	-1.1
Number of full brothers	1.0	1.2	2.4	0.9	-0.2	1.5	-1.2	1.1	1.3
Worry too long after embarrassment	1.0	1.6	2.2	1.2	0.0	1.4	-1.4	1.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.4	-0.3	-0.6	0.8	-0.6	-0.8
Wheeze or whistling in the chest in last year	1.1	2.0	2.7	1.3	1.5	1.5	-1.6	0.9	1.7
Number of children fathered	0.0	0.0	0.1	-0.3	0.2	-0.3	0.2	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.2	-0.2	0.2	-0.1	-0.0	0.3
Age at first live birth	0.1	0.1	0.7	-0.1	-0.9	-0.2	-0.0	0.2	0.1
Pulse wave peak to peak time	0.3	0.4	0.7	0.8	0.5	0.4	-0.7	0.2	0.8
Health satisfaction	4.5	5.8	7.3	-2.5	-1.5	-2.5	2.6	-2.4	-2.7
Shortness of breath walking on level ground	0.9	1.1	1.3	1.0	1.1	1.1	-1.1	1.0	1.0
Qualifications: College or University degree	0.1	0.4	1.3	0.5	-1.2	0.1	-0.0	0.8	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.2	0.5	0.3	-0.1	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.3	0.6	1.5	0.7	-0.9	0.7	1.1
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.1	0.5	0.1	-0.3	0.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.4	2.5	0.2	-1.6	0.1	-0.3	0.2	0.2
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.1	0.6	0.2	-0.2	-0.1	0.2
Medication: Blood pressure	0.0	0.1	0.2	0.1	-0.0	0.4	-0.1	0.4	0.1
Angina (self-reported)	0.3	0.3	1.9	-0.2	1.4	-0.0	-0.0	-0.2	0.1
Migraine (self-reported)	9.2	11.4	12.5	-3.5	-2.7	-3.4	3.5	-3.5	-3.5
Medication: Ibuprofen	1.0	1.2	1.9	-0.8	0.1	-1.2	1.4	-1.2	-1.3
Medication: Allopurinol	0.3	0.4	0.9	0.5	1.0	0.4	-0.6	0.6	0.5
Medication: Omeprazole	0.7	0.8	4.1	0.4	2.0	0.3	-0.4	0.2	0.6
Medication: Seretide 50 evohaler	2.0	2.3	3.3	1.8	1.6	1.4	-1.4	1.2	1.6
Mean time to correctly identify matches	3.5	6.7	8.2	2.5	2.9	2.5	-2.5	2.8	2.3
Heart disease (mother)	0.2	0.2	0.7	0.2	0.8	0.3	-0.4	0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.1	0.2	0.0
Whole body fat mass	1.8	7.7	11.2	-3.1	-2.0	-2.7	2.7	-3.4	-2.5
Leg fat mass (right)	1.9	7.5	11.0	-3.1	-1.7	-2.8	2.7	-3.3	-2.5
Arm predicted mass (right)	3.9	20.1	21.8	-4.3	-4.6	-4.2	4.6	-4.7	-4.5
Pulse rate, automated reading	0.3	0.8	1.5	0.7	0.2	1.1	-1.1	0.7	1.2
Alcohol intake frequency.	0.0	0.0	0.2	-0.1	0.2	0.1	0.1	-0.4	-0.0
Comparative height size at age 10	4.0	22.0	28.3	-4.5	-5.3	-4.3	4.7	-4.6	-4.7
Number of full sisters	0.6	0.8	1.7	0.9	1.3	0.8	-0.8	0.3	0.9
Suffer from ‘nerves’	3.6	5.7	8.6	2.0	1.7	2.6	-2.6	2.9	2.2
Overall health rating	0.0	0.1	0.2	-0.4	0.1	-0.1	0.1	-0.5	0.0
Chest pain or discomfort	1.0	1.4	3.6	0.7	1.9	1.1	-1.1	0.5	1.3
Had major operations	6.5	7.6	8.9	-2.8	-2.7	-2.7	2.8	-3.0	-2.5
Age at last live birth	0.1	0.1	0.2	0.2	-0.5	0.3	-0.3	0.5	0.3
Family relationship satisfaction	0.3	0.4	1.2	0.8	1.1	0.5	-0.3	0.4	0.2
Leg pain on walking	3.8	4.7	5.7	-2.4	-2.2	-2.0	2.1	-2.3	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.3	0.0	0.5	0.0	-0.1	-0.2	0.2
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.1	-1.8	-0.7	-1.5	1.5	-1.4	-1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.5	0.2	-0.7	0.5	-0.8	-0.5
Medication: Aspirin	1.8	2.4	4.8	1.2	2.2	1.4	-1.4	1.4	1.4
Supplements: Vitamin C	0.4	0.5	0.6	0.8	0.6	0.7	-0.6	0.7	0.7
Knee pain experienced in last month	2.8	4.3	5.9	-2.4	-1.8	-2.0	2.0	-2.3	-1.9
Hypertension (Self-reported)	0.4	1.0	1.8	1.0	1.0	1.4	-0.8	0.7	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	5.7	0.3	2.4	0.7	-0.9	0.4	0.9
Illnesses of father: Heart disease	2.3	3.2	3.9	2.0	1.7	1.9	-1.8	1.4	1.8
Illnesses of siblings: Diabetes	0.2	0.3	1.3	-0.4	-1.1	-0.2	0.1	-0.2	-0.1
Smoking status: Previous	0.2	0.3	1.3	0.4	1.1	0.4	-0.2	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	7.9	-2.1	-2.8	-1.9	2.0	-1.9	-2.0
Whole body fat-free mass	3.3	18.9	22.3	-4.1	-4.7	-4.0	4.4	-4.5	-4.3
Leg fat-free mass (right)	2.5	13.4	16.9	-3.4	-4.1	-3.2	3.7	-3.9	-3.5
Arm fat percentage (left)	0.5	1.9	3.4	-1.7	-0.1	-1.4	1.3	-1.8	-1.1
Average weekly red wine intake	0.1	0.2	0.4	0.6	0.3	0.3	-0.2	0.6	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.2	-0.2	-0.2	0.1	0.2	-0.4	-0.1
Mood swings	2.3	4.2	5.3	2.2	1.3	2.0	-2.2	2.1	2.3
Loneliness, isolation	1.5	2.0	3.4	1.3	1.8	1.4	-1.3	1.3	1.4
Long-standing illness, disability or infirmity	0.4	0.6	1.5	0.7	1.2	0.6	-0.7	0.4	0.7
Ever had bowel cancer screening	1.8	2.1	2.5	-1.4	-1.3	-1.5	1.4	-1.6	-1.4
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.8	-0.6	-0.2	0.1	-0.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.1	-0.2	0.1	-0.0	0.4	0.1
Friendships satisfaction	0.4	0.4	0.6	0.6	0.5	0.8	-0.8	0.6	0.7
Qualifications: nursing, teaching	0.2	0.3	0.7	0.9	0.3	0.4	-0.4	0.6	0.4
Commuting to job workplace: Walk	0.9	0.9	1.3	1.1	1.1	0.9	-0.9	0.9	0.9
Eye problems/disorders: Cataract	0.7	0.8	1.0	-1.0	-1.0	-0.8	0.9	-1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.2	-0.0	1.1	0.3	-0.4	0.2	0.4
Medication for cholesterol	0.2	0.3	1.3	0.1	-1.1	-0.4	0.2	0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	6.6	-2.2	-1.8	-1.8	1.8	-2.6	-1.6
Back pain experienced in last month	0.7	1.0	2.5	1.0	1.6	0.9	-0.8	0.6	0.8
Mineral and other dietary supplements	0.0	0.0	0.1	0.0	-0.3	0.3	-0.0	-0.0	-0.0
Breast cancer (self-reported)	0.3	0.3	0.4	-0.7	-0.6	-0.6	0.6	-0.6	-0.5
Asthma (self-reported)	5.5	11.0	12.2	3.4	3.1	3.4	-3.4	3.1	3.5
Osteoporosis (self-reported)	6.1	7.6	11.3	2.4	3.4	2.7	-2.7	2.6	2.6
Osteoarthritis (self-reported)	0.0	0.0	0.3	-0.1	0.5	0.1	0.0	0.1	-0.0
Medication: Aspirin	2.1	2.7	4.0	1.4	2.0	1.5	-1.6	1.6	1.7
Medication: Gliclazide	0.1	0.1	0.2	-0.2	-0.4	-0.5	0.2	-0.4	-0.2
Illnesses of father: None of the above (group 1)	3.5	4.4	5.0	-2.2	-2.0	-2.2	2.1	-1.8	-2.1
Smoking status: Current	0.2	0.4	0.6	0.4	0.8	0.4	-0.6	0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.9	0.8	1.4	1.0	-1.1	1.1	1.1
Whole body water mass	3.3	18.7	22.0	-4.1	-4.7	-3.9	4.4	-4.5	-4.3
Leg predicted mass (right)	2.6	13.7	17.2	-3.5	-4.2	-3.2	3.7	-4.0	-3.6
Arm fat mass (left)	1.4	5.8	8.9	-2.7	-1.6	-2.4	2.4	-3.0	-2.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.4	0.3	1.2	0.6	-0.3	-0.1	0.4
Average weekly champagne plus white wine intake	0.7	1.0	1.3	-1.0	-1.2	-1.0	1.0	-0.7	-1.1
Miserableness	0.5	0.9	1.2	0.8	0.8	1.1	-0.9	1.0	1.0
Guilty feelings	0.7	1.1	1.5	0.9	0.4	1.2	-1.2	1.2	1.1
Wears glasses or contact lenses	0.4	0.4	0.5	0.6	0.7	0.7	-0.6	0.6	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.5	-0.2	-0.3	0.4	-0.2	-0.4
Hearing aid user	0.0	0.0	0.1	-0.2	0.3	-0.1	0.2	-0.1	-0.3
Mother’s age at death	0.4	0.6	1.3	1.1	0.7	0.6	-0.6	0.8	0.5
Financial situation satisfaction	0.0	0.1	0.2	-0.2	-0.4	-0.1	0.1	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.0	0.1	0.1	-0.1	0.1	-0.3	0.2	-0.3	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.2	-0.5	0.3	-0.2	0.3	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.8	-0.5	-1.4	-0.6	0.5	-0.1	-0.5
Medication: Blood pressure	0.4	0.8	1.3	0.8	1.1	1.1	-0.8	0.5	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-0.5	1.2	-0.6	0.5	-0.8	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.4	0.6	-0.5	0.3	-0.6	-0.2
High cholesterol (Self-reported)	0.9	1.6	2.0	1.1	1.4	1.3	-1.3	1.1	1.3
Medication: Bendroflumethiazide	0.3	0.4	1.3	-0.6	-0.1	-0.5	0.6	-1.1	-0.6
Medication: Paracetamol	1.0	1.6	2.0	-1.4	-0.3	-1.3	1.4	-1.3	-1.4
Medication: Lisinopril	0.5	0.7	1.1	0.5	1.0	0.9	-0.8	0.6	0.8
Medication: Atorvastatin	4.4	5.5	5.9	2.4	2.4	2.4	-2.4	2.1	2.4
Illnesses of father: High blood pressure	0.7	0.9	1.6	1.1	1.3	0.8	-0.9	0.7	0.8
Alcohol drinker status: Never	0.6	0.8	1.1	-0.9	-0.3	-0.9	1.0	-0.9	-1.0
Ever smoked	0.3	0.5	1.1	-0.8	-0.2	-0.6	0.7	-1.1	-0.6
Basal metabolic rate	3.3	18.5	21.2	-4.1	-4.5	-3.9	4.4	-4.6	-4.2
Leg fat percentage (left)	1.1	3.9	6.6	-2.4	-0.0	-2.1	1.9	-2.6	-1.7
Arm fat-free mass (left)	4.1	21.0	22.8	-4.4	-4.6	-4.3	4.8	-4.8	-4.7
Number of operations (self-reported)	2.6	3.8	4.5	-2.1	-1.6	-1.8	2.0	-2.0	-2.0
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.7	0.1	-0.3	0.2	-0.4	-0.1
Irritability	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	0.1	-0.2
Risk taking	0.7	1.1	1.4	0.9	0.6	1.0	-1.1	1.2	1.2
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	-1.0	-1.0	-1.1	0.9	-1.2	-0.8
Fractured/broken bones in last 5 years	2.2	2.8	3.4	-1.7	-1.8	-1.4	1.7	-1.6	-1.7
Age started oral contraceptive pill	0.2	0.3	1.4	0.2	1.2	-0.1	-0.1	0.2	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.4	0.1	0.6	0.2	-0.2	-0.1	0.2
Ever depressed for a whole week	0.1	0.2	0.9	0.1	0.9	0.3	-0.2	0.3	0.1
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	0.5	-0.2	0.2	-0.4	-0.0
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.6	0.1	0.1	-0.2	0.5	0.0
Myopia	0.0	0.0	0.1	-0.0	-0.3	0.3	0.1	-0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.0	-0.5	-0.7	-1.0	0.6	-0.3	-0.7
Cholesterol lowering medication	1.2	1.8	3.1	1.0	1.8	1.6	-1.2	1.0	1.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.4	0.6	2.1	0.6	-0.8	0.6	0.9
Pain experienced in last month	0.4	0.6	1.7	-0.5	-1.3	-0.6	0.7	-0.3	-0.8
Supplements: Calcium	0.2	0.2	1.1	0.3	1.0	-0.2	-0.2	0.4	0.1
Basal cell carcinoma (self-reported)	0.9	1.1	1.8	1.0	1.3	0.9	-0.9	1.1	1.0
Heart attack/myocardial infarction (self-reported)	5.8	7.5	8.5	-2.9	-2.9	-2.8	2.6	-2.5	-2.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.3	-0.5	-1.1	-0.0	-0.1	-0.1	0.1
Heart disease (siblings)	1.2	1.5	1.9	-1.4	-1.2	-1.2	1.2	-0.9	-1.3
Alcohol drinker status: Previous	0.2	0.2	0.3	0.6	0.3	0.5	-0.4	0.3	0.5
Pack years of smoking	1.9	2.8	3.5	1.4	1.7	1.8	-1.6	1.9	1.7
Impedance of whole body	0.2	1.2	1.7	0.8	0.7	1.1	-1.3	1.3	1.2
Leg fat mass (left)	2.2	8.5	12.5	-3.3	-1.8	-2.9	2.9	-3.5	-2.7
Arm predicted mass (left)	3.8	19.4	21.0	-4.3	-4.4	-4.1	4.6	-4.6	-4.5