Hub : Genes

RUNX1T1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0290	0.00090	0.019	0.027	0.009	0.026	0.025	0.00210	0.00025	0.0250	3e-04	0.0004
2	GTEx	Heart Left Ventricle	0.1712	0.0630	0.00044	-0.005	NA	-0.001	NA	0.000	0.70000	NA	0.3500	NA	0.3300
3	GTEx	Nerve Tibial	0.0669	0.0321	0.00360	0.025	NA	-0.003	NA	0.003	0.00640	NA	0.6700	NA	0.1800
4	TCGA	Brain Lower Grade Glioma	0.0285	0.0185	0.00120	0.027	0.025	0.020	NA	0.020	0.00044	0.00068	0.0023	NA	0.0022

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.7	2.6	7.9	-0.3	-0.2	-2.8	1.6
Bipolar Disorder or Schizophrenia	0.4	0.9	1.9	0.9	-0.3	-1.4	1.0
Depressed Affect (Nagel 2018)	1.1	2.4	9.2	-0.5	-3.0	0.5	-0.2
Depression (Nagel 2018)	2.3	3.5	5.6	0.2	-2.4	-2.0	2.1
Intelligence (Savage-Jansen 2018)	7.4	22.7	53.7	1.0	-1.9	-7.3	5.7
Neuroticism (Nagel 2018)	0.3	0.8	2.2	-0.5	-1.5	0.9	0.1
Schizophrenia (2018)	0.3	0.5	1.9	1.4	-0.2	0.5	-0.0
Schizophrenia vs Biploar Disorder	1.5	2.0	4.6	-0.3	-1.8	2.1	-0.1
Worry (Nagel 2018)	1.1	2.3	5.3	-0.0	1.2	2.3	-1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	0.8	1.1	-0.1	-0.0
Alzheimer’s Disease (in father)	0.8	0.9	3.1	1.8	-0.1	0.2	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	4.1	2.0	0.6	0.3	-0.4
Crohns Disease (2017)	0.5	1.1	4.2	0.5	-2.1	0.3	-0.1
Irritable Bowel Disease (IBD)	0.5	1.1	2.4	1.4	-1.6	-0.3	-0.2
Ulcerative Colitis (UC)	0.8	1.6	5.4	2.3	-0.6	-0.2	-0.7
Major Depression (MDD)	1.7	2.1	7.9	-0.4	-2.8	-0.6	0.1
Reaction Time	0.6	1.1	2.2	1.5	-0.0	1.2	-0.7
Verbal and Numeric Reasoning (VNR)	3.7	8.9	19.8	0.7	-2.0	-4.5	3.4
Breast Cancer	0.4	0.9	2.2	-0.6	1.5	-0.5	0.8
Ovarian Cancer	4.4	5.8	16.7	1.2	4.1	-1.6	1.6
Prostate Cancer	1.3	1.8	5.8	-2.4	1.0	-0.2	0.4
Age at First Birth	2.2	3.3	6.5	-1.1	-0.0	2.5	-2.3
Bipolar Disorder (2011)	1.4	1.4	3.5	1.2	0.3	0.6	-1.9
Body Mass Index (BMI) (2010)	1.0	1.3	3.5	0.5	-0.7	-1.0	1.9
Coronary Artery Disease (CAD)	1.2	1.4	3.2	-1.8	-1.6	-0.1	-0.1
Crohns Disease (2012)	0.9	1.4	5.3	0.3	-2.3	-0.4	0.1
Mean Putamen Volume	0.6	0.7	1.7	-1.0	1.3	-0.5	0.1
Fasting Glucose	0.4	0.5	0.9	1.0	0.8	-0.5	0.2
HbA1C	2.0	2.3	3.2	-0.5	1.7	-1.6	1.8
HDL Cholesterol	0.4	0.7	1.7	-1.3	-1.0	-0.4	0.0
LDL Cholesterol	0.9	1.5	2.3	-0.2	-1.3	1.4	-1.5
Lupus	3.5	5.3	8.5	-1.1	1.8	-2.9	2.9
Neuroticism (2016)	0.2	0.2	0.5	0.7	-0.2	0.4	-0.5
Primary Biliary Cirrhosis	2.8	4.0	5.7	1.7	-2.4	2.0	-1.9
Rheumatoid Arthritis	0.8	1.1	1.3	-0.8	-1.1	-1.1	1.1
Schizophrenia (2014)	0.3	0.8	1.7	1.3	-0.9	-0.4	0.7
Triglycerides	1.3	2.1	4.7	-1.3	0.0	-1.5	2.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.1	0.4	-0.8	0.8
Ulcerative Colitis	0.6	0.8	2.5	1.6	-0.7	-0.6	-0.0
Blood Eosinophil Count	0.1	0.7	1.2	1.1	0.2	1.0	-0.8
Blood Platelet Count	0.3	3.8	7.1	1.2	-0.5	2.5	-2.7
Blood Red Count	0.3	2.9	11.1	-0.5	-3.3	-0.2	0.2
Blood White Count	0.1	0.5	1.3	1.1	-0.7	-0.2	-0.0
Heel T-Score	1.0	7.8	28.5	5.3	1.4	-0.8	0.1
BMI	1.8	10.4	14.9	1.8	-3.7	-3.2	3.9
Height	0.1	1.0	2.1	-0.7	1.4	-0.4	1.1
Waist Hip Ratio (WHR)	1.7	7.4	11.7	-2.1	1.4	-3.4	3.4
Systolic Blood Pressure	1.2	6.2	14.1	-3.1	3.8	-0.0	1.1
Smoking Status	3.0	7.1	16.0	2.5	-4.0	-2.0	1.6
Allergy or Eczema	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.4
Cardiovascular Disease	1.6	5.4	10.0	-1.5	-0.4	-3.0	3.2
Hypothyroidism (self reported)	0.5	1.1	1.9	-0.6	0.5	1.4	-1.4
Respiratory disease	1.3	2.8	4.3	-2.1	-1.9	-1.0	1.6
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.2	1.0	0.1	-2.3	1.5
Lung FEV1/FVC ratio	1.1	5.5	9.1	0.8	-2.5	3.0	-2.5
Lung FVC	0.8	3.9	11.5	1.8	3.4	-0.7	0.6
Neuroticism	0.1	0.3	0.8	0.1	-0.9	-0.0	0.8
Chronotype (morning person)	3.7	8.5	14.5	-2.4	3.8	3.0	-2.2
Hair Pigment	0.0	0.5	1.0	-0.4	0.9	0.3	1.0
Tanning	0.0	0.0	0.1	0.2	-0.1	0.3	0.3
Hand grip strength (left)	0.4	0.9	1.6	1.3	-1.1	-0.2	0.9
Number of treatments/medications taken	1.3	2.4	4.6	-2.0	-2.1	-0.9	0.7
Average weekly spirits intake	0.3	0.4	1.2	0.3	-1.1	-0.0	-0.4
Sensitivity / hurt feelings	1.6	2.8	6.3	-0.5	1.6	-1.4	2.5
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.5	-0.6	-0.1	-1.1	1.6
Hearing difficulty/problems: Yes	0.0	0.1	0.2	0.4	0.1	-0.2	0.1
Relative age of first facial hair	0.1	0.2	0.5	-0.5	-0.7	-0.1	0.1
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	8.2	-1.3	-1.4	-2.9	2.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	1.0	-1.4	0.0	0.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.7	0.8	-0.2	0.9	-1.3
Systolic blood pressure, automated reading	0.4	1.1	2.4	-1.0	1.6	0.3	0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.0	1.2	1.4	0.8	-0.7
Angina	1.6	2.1	3.7	-1.4	0.5	-1.6	1.9
Medication for hormone replacement therapy	0.5	0.5	0.7	0.8	-0.8	0.7	-0.5
Vitamin and mineral supplements	0.9	1.2	2.6	1.4	-1.6	0.0	-0.6
Supplements: Zinc	1.8	2.0	3.3	0.6	-1.1	-1.8	1.7
Medication: Co-codamol	0.2	0.2	0.7	0.3	0.9	-0.4	0.0
Medication: Metformin	1.4	1.9	4.2	0.1	0.5	-2.0	1.8
Diabetes (father)	0.1	0.1	0.3	0.4	0.1	-0.5	-0.1
Diabetes (mother)	0.3	0.4	1.1	-0.4	-0.3	-0.4	1.1
Severe depression (siblings)	0.1	0.1	0.4	0.2	0.6	-0.2	0.3
Pack years adult smoking proportion	0.9	1.3	1.9	-1.4	-0.6	-1.2	1.3
Impedance of leg (right)	0.9	4.1	10.3	-3.2	1.9	1.1	-1.1
Leg fat-free mass (left)	1.1	5.6	8.5	2.4	-2.0	-2.1	2.9
Trunk fat percentage	1.7	6.6	11.4	0.4	-2.4	-3.1	3.4
Hand grip strength (right)	0.3	0.8	2.6	0.2	-0.4	-0.6	1.6
Townsend deprivation index at recruitment	1.1	1.5	2.0	1.4	1.4	1.1	-1.0
Current tobacco smoking	0.2	0.4	0.7	0.6	-0.7	-0.8	0.4
Average weekly fortified wine intake	0.9	1.1	3.1	0.4	-1.8	-1.1	0.2
Maternal smoking around birth	8.6	12.4	25.4	-0.1	-0.9	-4.9	5.0
Fed-up feelings	0.3	0.5	1.7	-0.3	-1.3	0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.0	0.6	-1.4	-1.2	0.9
Relative age voice broke	0.1	0.2	0.5	-0.0	-0.7	0.3	-0.4
Taking other prescription medications	2.3	3.6	8.0	-2.3	-2.8	-0.7	0.8
Age when periods started (menarche)	0.2	0.6	1.8	0.6	1.4	-0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.0	0.9	-0.7	0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	10.0	3.2	1.2	-1.1	1.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-1.2	0.1	-1.0	0.5
Qualifications: CSEs or equivalent	1.2	1.5	5.0	-2.2	-0.3	0.9	-0.5
Serious illness, injury or assault to yourself	2.0	2.4	5.3	0.9	-0.2	-2.3	1.9
High blood pressure	1.7	4.6	7.7	-1.8	-0.7	-2.7	2.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	-0.0	0.1	0.8	-0.3
Multivitamins +/- minerals	1.1	1.4	3.1	0.0	1.8	-0.8	1.4
Stomach or abdominal pain in last month	0.3	0.3	0.8	0.4	-0.9	0.6	-0.3
Supplements: Glucosamine	0.4	0.5	1.6	0.4	1.3	-0.2	0.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	4.5	-1.2	-1.2	-2.1	1.9
Medication: Atenolol	0.9	1.1	1.8	-0.9	-0.8	-1.3	1.1
Medication: Levothyroxine sodium	1.4	2.4	4.6	-0.2	1.1	2.0	-2.1
Sitting height	0.1	0.4	1.2	-0.4	-0.4	1.1	-0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	1.8	0.3	0.9	-1.3	0.7
High blood pressure (mother)	1.1	1.6	3.5	-0.7	-0.4	1.9	-1.4
Body mass index (BMI)	2.2	9.2	13.7	1.6	-3.1	-3.4	3.7
Impedance of leg (left)	0.9	4.3	10.3	-3.2	1.9	1.2	-1.3
Leg predicted mass (left)	1.1	5.6	8.1	2.5	-2.0	-2.0	2.8
Trunk fat mass	2.0	8.6	14.9	0.7	-2.9	-3.3	3.9
Waist circumference	2.2	8.0	13.3	0.2	-2.6	-3.4	3.7
Number of incorrect matches in round	1.3	2.2	3.2	1.0	1.8	1.5	-1.5
Past tobacco smoking	3.8	6.9	14.6	-2.0	3.8	2.5	-1.6
Alcohol usually taken with meals	0.4	0.7	2.3	-0.3	-1.5	0.5	-0.3
Nervous feelings	1.7	3.2	8.4	0.2	0.9	2.9	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.3	-0.9	-0.3	1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.9	-0.3	0.5	-0.0
Hair/balding pattern: Pattern 2	1.4	1.7	6.5	-0.0	2.5	0.2	0.7
Had menopause	0.2	0.2	0.4	0.7	0.1	-0.1	-0.5
Had other major operations	3.1	3.8	11.2	-0.7	-3.3	-1.1	1.5
Forced vital capacity (FVC)	0.6	2.4	8.7	0.9	3.0	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	20.2	4.5	0.7	-0.8	0.9
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	8.8	-0.4	-3.0	0.8	-1.8
Qualifications: None of the above	0.9	1.9	3.6	0.5	1.1	1.9	-1.6
Financial difficulties in last 2 years	1.0	1.4	3.2	0.1	-0.4	-1.8	1.4
Mouth/teeth dental problems	1.0	1.6	4.2	-0.8	-2.1	1.1	-0.4
Heart attack	1.2	1.6	3.7	0.2	-0.0	-1.6	1.9
Allergy	0.1	0.2	0.5	0.0	0.7	-0.2	-0.3
Pain all over the body in last month	0.1	0.1	0.2	0.4	-0.3	-0.4	0.2
Diabetes (self-reported)	1.6	2.5	6.1	0.8	0.0	-2.5	1.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	0.1	0.2	-0.8	1.3
Medication: Ramipril	2.3	2.9	5.3	0.4	1.0	-2.3	2.3
Medication: Simvastatin	0.2	0.3	0.8	0.2	0.7	-0.9	0.1
Fluid intelligence score	3.1	6.5	14.1	1.6	-1.8	-3.8	2.5
Illnesses of siblings	0.1	0.1	0.2	-0.3	-0.3	0.1	0.4
Neuroticism score	0.1	0.1	0.3	-0.3	-0.2	0.6	0.2
Weight	1.7	8.5	14.2	1.3	-2.9	-3.1	3.8
Impedance of arm (right)	0.8	3.9	13.7	-0.7	3.7	0.7	-0.9
Arm fat percentage (right)	1.9	7.5	12.3	1.8	-2.2	-3.2	3.5
Trunk fat-free mass	0.5	2.8	3.6	1.7	-1.9	-1.1	1.9
Hip circumference	0.8	3.4	6.2	1.2	-2.5	-1.5	1.9
Time employed in main current job	1.2	1.4	4.3	-0.8	2.1	0.8	-0.2
Alcohol intake versus 10 years previously	1.4	2.2	5.6	0.8	-2.4	-1.2	1.0
Father’s age at death	0.1	0.2	0.4	-0.6	0.1	0.5	-0.2
Worrier / anxious feelings	0.8	1.6	2.8	-0.6	1.7	1.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.3	1.2	-1.0	-0.9	0.7
Falls in the last year	0.4	0.6	1.0	-0.6	0.6	-0.8	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	-1.0	-0.4	-0.0	0.6
Number of live births	1.0	1.4	2.4	-1.0	0.2	-1.4	1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.6	0.9	2.4	1.3	-0.6
Pulse rate	0.4	0.6	1.4	0.9	-1.2	0.5	-0.2
Happiness	1.8	2.2	4.3	0.4	-2.1	-1.6	1.3
Noisy workplace	0.2	0.2	0.5	-0.4	-0.7	-0.5	0.0
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.5	0.2	-1.2	-2.4	1.6
Serious illness, injury or assault of a close relative in last 2 years	4.2	4.8	9.5	-0.2	-0.6	-3.1	3.0
Mouth/teeth dental problems: Dentures	0.9	1.5	3.7	1.3	0.5	-1.9	0.7
Asthma	1.9	3.7	7.9	-1.5	-1.0	-1.9	2.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	0.3	-1.5	-0.3	0.6
Medication: Cholesterol lowering	1.4	2.2	3.5	-1.4	-0.6	-1.9	1.7
Depression (self-reported)	2.0	2.4	8.5	0.2	-2.9	-0.6	0.7
Medication: Lansoprazole	0.3	0.3	0.8	-0.1	0.3	0.7	-0.9
Prospective memory result	0.1	0.2	0.3	0.6	-0.5	0.0	-0.3
Lung cancer (father)	2.5	2.9	5.7	-0.5	0.4	-2.4	2.4
Illnesses of mother	0.5	0.6	1.1	0.8	-1.0	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.5	0.7	1.9	1.1	-0.5
Pulse wave Arterial Stiffness index	1.4	1.7	2.9	-0.3	-1.0	-1.7	1.7
Impedance of arm (left)	0.9	4.0	12.5	-1.6	3.5	0.7	-0.7
Arm fat mass (right)	2.0	8.3	13.8	1.7	-2.6	-3.1	3.7
Trunk predicted mass	0.5	3.0	3.7	1.8	-1.9	-1.2	1.9
Standing height	0.0	0.1	0.2	-0.2	0.2	0.3	0.4
Length of working week for main job	1.3	1.5	4.0	2.0	-1.0	-0.1	0.9
Exposure to tobacco smoke at home	1.1	1.2	3.4	-0.3	-1.8	-0.7	1.0
Breastfed as a baby	0.7	0.9	1.7	0.7	-1.3	0.4	-1.0
Tense / ‘highly strung’	0.2	0.3	0.7	-0.0	0.6	0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	7.2	0.5	-2.7	-1.7	0.9
Hair/balding pattern: Pattern 4	0.6	1.4	3.0	1.7	-1.0	-1.2	-0.2
Birth weight of first child	0.6	1.2	2.6	1.1	-0.3	-1.6	0.9
Peak expiratory flow (PEF)	0.6	1.3	2.5	-0.2	1.3	-0.9	1.6
Pulse wave reflection index	0.3	0.4	0.8	-0.6	-0.3	-0.7	0.9
Ever highly irritable/argumentative for 2 days	1.4	1.6	6.3	-0.1	-2.5	0.2	-0.5
Loud music exposure frequency	1.1	1.2	2.7	0.1	-0.4	-1.6	1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	-0.2	-1.2	-1.0	0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	2.5	-0.9	1.6	-1.2	1.0
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.1	0.6	-0.1	-0.1
Medication: Paracetamol	2.5	4.1	14.5	0.5	-3.8	0.8	-1.1
Headache pain in last month	1.5	2.6	5.0	-1.3	-1.5	1.2	-2.2
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	6.2	2.3	0.6	2.5	-2.5
Glaucoma (self-reported)	0.3	0.3	0.9	0.5	1.0	0.2	-0.3
Gout (self-reported)	0.2	0.3	1.2	-0.0	1.1	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.6	0.6	0.3	-0.5
Medication: Amlodipine	0.6	0.8	1.7	0.6	-1.3	-0.8	0.8
Medication: Ventolin 100micrograms inhaler	2.3	2.9	7.8	-2.8	-0.1	-0.8	1.8
Birth weight	0.4	0.9	1.2	0.6	-1.0	0.9	-1.1
Chronic bronchitis/emphysema (mother)	5.9	6.8	12.5	-0.6	1.5	-3.5	3.5
High blood pressure (siblings)	0.5	0.7	1.4	0.5	1.2	-0.8	0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	5.0	0.6	2.2	-0.1	0.5
Body fat percentage	2.2	8.7	14.9	0.3	-2.8	-3.5	3.9
Leg fat percentage (right)	3.1	11.1	19.0	0.2	-3.1	-4.0	4.4
Arm fat-free mass (right)	1.0	5.0	9.1	1.1	-3.0	-1.8	2.5
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.3	-1.0	0.2	-0.2
Comparative body size at age 10	0.2	0.5	1.0	0.1	-0.5	-0.9	1.0
Number of full brothers	0.1	0.2	0.6	0.2	-0.1	-0.7	0.3
Worry too long after embarrassment	0.7	1.2	4.0	-2.0	-0.1	1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	5.7	-0.0	-2.4	-0.3	-0.4
Wheeze or whistling in the chest in last year	1.6	2.8	4.1	-0.8	-2.0	-1.8	1.8
Number of children fathered	2.0	2.2	4.6	-2.1	1.2	1.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	0.2	-1.4	1.0	-0.5
Age at first live birth	1.4	2.5	3.7	-1.1	1.9	1.9	-1.3
Pulse wave peak to peak time	1.5	1.7	3.1	0.3	1.0	1.8	-1.7
Health satisfaction	1.5	2.0	3.3	-1.6	0.5	-1.4	1.8
Shortness of breath walking on level ground	1.9	2.2	8.0	-0.9	-2.8	-0.3	0.2
Qualifications: College or University degree	0.7	2.1	3.9	1.1	0.6	-2.0	1.7
Eye problems/disorders: None of the above	1.0	1.1	3.7	-1.9	-0.8	-0.1	0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.2	0.6	-1.0	-1.8	1.1
Emphysema/chronic bronchitis	1.8	2.1	5.4	-0.0	-2.3	-1.1	1.4
Medication for pain relief, constipation, heartburn	0.9	1.6	5.5	0.5	2.3	0.5	-0.6
Neck or shoulder pain in last month	0.2	0.3	0.6	0.1	-0.6	0.5	-0.8
Medication: Blood pressure	1.1	2.0	3.2	-1.8	-0.7	-1.3	1.5
Angina (self-reported)	1.8	2.3	3.9	-1.4	0.7	-1.7	2.0
Migraine (self-reported)	0.6	0.7	2.0	-1.4	0.2	0.5	-0.7
Medication: Ibuprofen	0.2	0.3	0.6	0.7	-0.8	0.1	0.1
Medication: Allopurinol	0.5	0.7	1.8	-0.6	-0.2	-0.6	1.4
Medication: Omeprazole	1.4	1.7	2.7	-0.6	-1.6	-1.4	1.3
Medication: Seretide 50 evohaler	1.3	1.5	2.6	-0.1	-1.6	-1.4	1.2
Mean time to correctly identify matches	0.4	0.8	1.8	0.5	-0.3	1.3	-1.0
Heart disease (mother)	0.9	1.1	2.0	-0.8	1.4	-0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	0.1	-0.0	0.0
Whole body fat mass	2.3	9.6	16.5	0.8	-3.1	-3.4	4.1
Leg fat mass (right)	3.1	11.9	20.3	0.6	-3.6	-3.8	4.5
Arm predicted mass (right)	1.0	5.1	9.2	0.8	-3.0	-1.8	2.7
Pulse rate, automated reading	0.5	1.6	3.2	0.4	-1.8	-1.0	1.3
Alcohol intake frequency.	2.4	5.7	12.8	-1.1	0.8	2.9	-3.6
Comparative height size at age 10	0.2	1.0	1.6	-1.2	-0.9	1.3	-0.5
Number of full sisters	0.8	1.0	3.7	1.9	0.2	-0.1	0.5
Suffer from ‘nerves’	3.5	5.4	10.2	1.4	0.4	3.2	-3.1
Overall health rating	1.9	4.2	9.5	-1.1	0.4	-2.4	3.1
Chest pain or discomfort	1.5	2.2	4.2	1.4	-2.1	-1.3	0.9
Had major operations	2.6	3.1	6.1	0.7	-1.0	-2.5	2.2
Age at last live birth	0.7	1.1	1.6	-0.4	1.3	1.2	-1.0
Family relationship satisfaction	0.7	0.9	3.1	0.3	-1.8	-0.5	0.1
Leg pain on walking	2.4	3.0	4.2	-0.6	-1.9	2.0	-2.0
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.8	6.9	1.7	-2.6	1.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.5	-1.6	-0.6	-0.5	0.8
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	5.0	-1.3	0.6	2.2	-1.6
Medication: Aspirin	0.1	0.1	0.3	-0.1	0.0	-0.3	0.5
Supplements: Vitamin C	1.0	1.2	1.8	1.3	0.8	1.0	-1.3
Knee pain experienced in last month	0.3	0.5	1.1	1.1	-0.5	0.5	-0.5
Hypertension (Self-reported)	1.5	4.2	6.3	-2.0	-0.9	-2.4	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.8	-0.6	0.5	-0.0
Illnesses of father: Heart disease	0.5	0.6	2.4	-1.5	0.2	0.3	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.1	-0.9	-0.0	0.1
Smoking status: Previous	3.8	5.7	17.5	2.2	-4.2	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.3	-0.0	1.5	0.2	0.5
Whole body fat-free mass	0.7	4.0	5.5	1.9	-2.1	-1.5	2.3
Leg fat-free mass (right)	0.8	4.4	6.4	2.2	-1.8	-1.8	2.5
Arm fat percentage (left)	2.4	9.5	16.1	1.3	-2.6	-3.6	4.0
Average weekly red wine intake	0.2	0.2	0.4	0.3	0.6	-0.4	0.5
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.1	2.2	-0.5	1.8	-1.9
Mood swings	1.7	3.1	5.5	0.2	-2.4	1.9	-1.8
Loneliness, isolation	1.4	1.9	3.2	-0.7	-1.3	-1.5	1.8
Long-standing illness, disability or infirmity	1.0	1.6	3.0	-0.2	-1.3	-1.7	1.3
Ever had bowel cancer screening	0.9	1.0	2.9	-0.1	-1.7	-0.8	0.7
Diabetes diagnosed by doctor	2.1	3.5	8.8	0.8	0.4	-3.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.1	1.5	-0.9	0.4	-0.7
Friendships satisfaction	0.6	0.8	0.9	1.0	-0.7	-0.9	0.8
Qualifications: nursing, teaching	0.2	0.2	0.5	-0.2	0.7	-0.6	0.3
Commuting to job workplace: Walk	1.9	2.1	5.9	-0.5	2.4	-1.3	0.6
Eye problems/disorders: Cataract	0.7	0.9	2.1	0.2	-0.2	-1.1	1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.3	-0.1	0.7	-0.8
Medication for cholesterol	0.4	0.7	1.6	-0.8	1.3	0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.3	-0.6	-0.2	-0.0
Back pain experienced in last month	2.4	3.4	6.7	-1.3	-2.6	1.7	-1.6
Mineral and other dietary supplements	1.0	1.4	3.4	1.4	-1.9	-0.4	0.0
Breast cancer (self-reported)	1.8	2.1	5.9	0.8	0.2	1.4	-2.4
Asthma (self-reported)	2.3	4.6	10.0	-1.4	-1.0	-2.3	3.2
Osteoporosis (self-reported)	0.9	1.1	1.7	-1.1	-0.6	-1.3	1.0
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.3	-1.0	-0.8	0.8
Medication: Aspirin	0.0	0.0	0.0	0.2	0.0	0.0	0.2
Medication: Gliclazide	0.6	0.7	2.6	1.6	-0.1	0.3	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	0.4	0.1	0.1
Smoking status: Current	0.2	0.3	0.5	0.5	-0.4	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.9	1.6	0.5	1.7	-1.1
Whole body water mass	0.7	3.9	5.1	2.1	-2.0	-1.4	2.3
Leg predicted mass (right)	0.8	4.5	6.5	2.3	-1.8	-1.8	2.5
Arm fat mass (left)	2.2	9.0	14.3	1.6	-2.9	-3.2	3.8
Number of self-reported non-cancer illnesses	4.3	7.4	10.8	-2.3	-1.7	-3.3	3.3
Average weekly champagne plus white wine intake	2.6	3.5	7.2	2.7	-2.4	0.4	-1.0
Miserableness	0.4	0.7	2.6	0.1	-1.6	0.3	-0.3
Guilty feelings	0.2	0.2	0.5	-0.6	-0.7	-0.0	0.3
Wears glasses or contact lenses	1.0	1.2	3.8	0.2	-2.0	0.0	-0.9
Ever taken oral contraceptive pill	2.1	2.3	4.0	-0.4	-1.6	-1.5	2.0
Hearing aid user	0.5	0.5	1.2	-0.6	-0.3	1.1	-0.7
Mother’s age at death	0.7	0.9	1.5	-1.1	0.0	1.2	-0.9
Financial situation satisfaction	0.4	0.5	0.8	-0.9	-0.9	-0.4	-0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	0.5	-1.4	0.4	-0.4
Commuting to job workplace: Public transport	1.6	1.9	6.6	2.6	-0.2	-0.1	-1.1
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.6	0.8	0.6	-0.3
Medication: Blood pressure	0.3	0.5	1.2	0.0	-0.5	-1.1	0.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	-1.4	-1.1	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	2.1	2.8	4.8	-1.8	2.2	1.5	-0.9
High cholesterol (Self-reported)	0.1	0.1	0.4	0.3	0.2	-0.6	-0.0
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.4	-0.3	-0.9	0.8
Medication: Paracetamol	2.6	4.0	13.4	0.9	-3.7	0.7	-1.2
Medication: Lisinopril	0.7	0.9	1.3	0.4	-1.1	1.0	-1.2
Medication: Atorvastatin	0.6	0.8	2.1	1.5	-0.8	-0.2	-0.4
Illnesses of father: High blood pressure	1.6	1.9	4.3	0.1	0.1	-1.8	2.1
Alcohol drinker status: Never	3.2	3.9	8.2	0.5	1.6	2.2	-2.9
Ever smoked	4.6	8.1	19.8	2.2	-4.4	-2.4	1.5
Basal metabolic rate	0.8	4.7	7.3	1.9	-2.1	-1.9	2.7
Leg fat percentage (left)	2.9	10.4	17.2	0.3	-3.1	-3.9	4.2
Arm fat-free mass (left)	1.0	5.0	7.1	1.5	-2.7	-1.9	2.6
Number of operations (self-reported)	3.4	5.0	7.1	-0.8	-2.3	-2.6	2.7
Average weekly beer plus cider intake	4.1	5.9	11.9	-1.0	2.3	-2.3	3.5
Irritability	1.7	2.8	6.3	0.8	-2.5	-1.3	1.7
Risk taking	4.8	7.0	14.8	-0.1	-2.4	-3.9	2.8
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.0	-1.4	-1.3	-0.8	0.7
Fractured/broken bones in last 5 years	1.2	1.6	2.4	-1.2	0.8	-1.6	1.4
Age started oral contraceptive pill	0.3	0.4	0.7	0.2	0.8	0.3	-0.9
Diastolic blood pressure, automated reading	1.3	4.0	10.2	-0.2	1.1	-2.1	3.2
Ever depressed for a whole week	2.0	2.4	5.6	-0.1	-1.0	1.8	-2.4
Unable to work because of sickness or disability	1.9	2.5	5.6	0.8	-1.3	-2.4	1.4
Commuting to job workplace: Cycle	0.7	0.9	1.4	-1.0	0.3	-1.2	1.0
Myopia	1.2	1.7	4.9	-0.4	-2.2	-1.1	0.7
Vascular/heart problems diagnosed by doctor	2.0	5.5	9.6	1.6	1.1	2.9	-3.1
Cholesterol lowering medication	0.5	0.8	2.2	1.5	0.2	-0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.1	-1.2	-0.9	-1.4	1.0
Pain experienced in last month	1.0	1.7	2.3	1.5	1.5	-1.0	1.1
Supplements: Calcium	0.8	0.9	3.6	1.9	0.1	0.0	-0.2
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	-0.5	0.4	0.9	-1.7
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.0	0.4	0.1	-1.3	1.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.0	0.5	0.0	-0.4
Heart disease (siblings)	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.2
Alcohol drinker status: Previous	1.5	1.7	5.6	-2.4	0.9	-0.3	0.0
Pack years of smoking	0.9	1.3	2.1	-1.5	-0.6	-1.2	1.2
Impedance of whole body	0.9	4.4	8.3	-2.6	2.9	1.0	-1.1
Leg fat mass (left)	2.8	11.1	18.5	0.8	-3.5	-3.6	4.3
Arm predicted mass (left)	1.0	5.3	7.2	1.9	-2.6	-2.0	2.7