TWAS hub - S1PR3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1326	0.0439	1.1e-03	0.000	NA	0.027	NA	0.005	3.1e-01	NA	3.4e-03	NA	1.3e-01
2	GTEx	Pancreas	0.1700	0.0610	3.1e-03	0.010	NA	-0.007	NA	-0.003	1.2e-01	NA	9.6e-01	NA	4.7e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1570	0.0570	2.9e-03	-0.001	NA	-0.003	NA	-0.004	4.0e-01	NA	5.0e-01	NA	7.0e-01
4	GTEx	Skin Sun Exposed Lower leg	0.2490	0.0780	1.9e-04	0.000	NA	-0.003	NA	0.007	3.2e-01	NA	6.3e-01	NA	7.2e-02
5	YFS	Blood	0.0752	0.0179	3.7e-10	0.032	0.044	0.046	0.046	0.046	1.3e-10	3.2e-14	7.1e-15	8e-15	9.3e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Commuting to job workplace: Car/motor vehicle	5.4	6.2	12.8	-0.8	-1.3	-3.3	-2.3	-3.6
LDL Cholesterol	2.8	4.5	16.7	0.4	0.8	1.8	1.2	4.1
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	10.3	0.2	-1.9	0.9	3.2	0.3
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	9.1	-0.2	0.4	2.7	0.8	3.0
Blood White Count	2.4	18.0	55.5	-0.4	-2.5	5.1	1.4	7.5
Serious illness, injury or assault to yourself	2.4	2.9	7.2	-1.1	-1.3	-1.6	-1.4	-2.7
Ever had prostate specific antigen (PSA) test	2.3	2.6	5.8	1.7	-2.0	-2.4	0.1	0.3
Blood clot in the leg (DVT)	2.2	2.8	6.9	-2.4	-0.6	-2.6	-1.1	-0.1
Emphysema/chronic bronchitis	2.2	2.5	7.4	0.5	2.7	2.2	0.3	0.1
Average weekly spirits intake	2.1	2.6	5.5	-2.4	-1.5	-1.0	-1.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.3	-2.2	-0.5	-2.7	-1.2	-0.0
Qualifications: CSEs or equivalent	2.0	2.7	7.6	2.8	2.0	-1.1	-0.4	0.8
Neck or shoulder pain in last month	2.0	2.9	8.3	-1.2	-1.7	-1.1	-0.6	-2.9
HbA1C	1.9	2.1	4.7	0.9	-1.3	-1.0	2.2	1.4
Migraine (self-reported)	1.9	2.4	6.9	0.1	-2.6	-0.4	2.1	-0.5
Pack years adult smoking proportion	1.8	2.7	4.9	-1.8	-1.7	-2.2	0.1	-1.6
Ever had bowel cancer screening	1.8	2.1	6.3	2.5	-0.1	-0.4	-0.7	1.8
Commuting to job workplace: Public transport	1.8	2.2	4.3	-0.7	1.6	2.1	-0.0	1.9
Systolic Blood Pressure	1.7	8.3	14.1	1.2	3.4	3.7	0.6	3.8
Pack years of smoking	1.7	2.4	4.7	-1.5	-1.9	-2.2	-0.1	-1.3
Vitamin and mineral supplements	1.6	2.1	7.3	-2.7	0.7	-1.5	0.8	-0.2
Severe depression (siblings)	1.6	1.8	3.4	1.3	1.8	1.6	0.9	0.7
Hair/balding pattern: Pattern 3	1.6	2.4	4.9	0.3	-1.9	-0.6	2.2	1.7
Number of full brothers	1.6	2.0	7.1	2.7	1.4	0.3	0.7	0.6
Osteoporosis (self-reported)	1.6	2.0	9.2	0.3	-0.1	-0.9	-3.0	0.3
Happiness	1.5	1.8	4.8	0.1	-0.7	0.3	-2.2	-1.9
Supplements: Fish oil (including cod liver oil)	1.5	1.9	4.6	1.7	0.2	1.2	-2.1	0.7
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.6	-0.6	-0.3	-1.5	-2.4	-1.6
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.9	-0.7	-0.7	-0.4	-2.0	-1.7
Irritability	1.4	2.3	4.9	2.2	-1.1	1.8	1.0	1.2
Fractured/broken bones in last 5 years	1.4	1.8	5.8	-0.5	-0.1	-2.4	0.3	-1.6
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	3.9	-0.2	-0.5	-0.9	-1.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	4.7	1.3	0.5	2.2	-0.2	0.3
Waist circumference	1.3	4.6	11.6	0.4	-1.2	-3.1	-0.4	-3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	5.8	0.7	-0.7	2.4	0.3	1.4
Medication: Omeprazole	1.3	1.6	4.8	1.4	0.9	-0.5	-2.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.0	-1.2	-0.8	-0.1	-1.5	-1.7
Medication: Bendroflumethiazide	1.3	2.0	6.8	-0.7	-0.5	-2.6	-0.6	-1.4
Townsend deprivation index at recruitment	1.2	1.7	4.5	1.3	0.2	2.1	-0.5	1.4
Glaucoma (self-reported)	1.2	1.4	3.8	1.9	0.2	1.0	-0.6	1.3
Leg fat mass (right)	1.2	4.8	13.0	0.4	-0.7	-3.6	0.0	-3.2
Chest pain or discomfort	1.2	1.8	3.1	0.7	1.0	1.6	1.8	1.2
Age at last live birth	1.2	1.7	6.2	-0.1	0.1	1.1	1.2	2.5
Commuting to job workplace: Walk	1.2	1.3	2.8	0.5	1.6	1.7	0.6	0.7
Leg fat mass (left)	1.2	4.7	11.6	0.1	-1.1	-3.4	0.1	-3.3
Rheumatoid Arthritis	1.1	1.5	3.8	0.7	-0.1	1.5	1.0	2.0
Blood Platelet Count	1.1	12.8	29.7	-3.8	-1.0	3.1	3.0	5.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.7	-1.2	-1.9	-0.0	-1.0	-0.6
Gout (self-reported)	1.1	1.6	4.8	-0.5	-2.2	-0.5	-0.8	-1.3
Whole body fat mass	1.1	4.8	12.0	-0.1	-1.0	-3.3	-0.5	-3.5
Supplements: Vitamin C	1.1	1.3	5.0	2.2	-0.3	0.7	0.1	-1.0
Illnesses of father: Heart disease	1.1	1.5	2.5	-1.3	0.0	-0.9	-1.5	-1.6
Schizophrenia vs Biploar Disorder	1.0	1.3	4.2	0.1	1.4	2.0	0.3	0.5
Major Depression (MDD)	1.0	1.2	3.9	0.1	-2.0	0.5	0.5	1.2
Age at First Birth	1.0	1.4	4.3	-2.1	1.2	0.4	1.0	-0.2
Systolic blood pressure, automated reading	1.0	2.9	5.6	1.4	2.3	2.4	0.4	1.2
Trunk fat percentage	1.0	4.0	12.5	-0.2	-0.5	-2.6	-0.7	-3.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.9	-1.3	-2.2	0.2	0.3	-0.3
Trunk fat mass	1.0	4.4	11.6	-0.1	-0.8	-3.0	-0.5	-3.4
Forced vital capacity (FVC)	1.0	3.9	13.7	0.7	1.2	0.6	3.7	1.9
Hip circumference	1.0	4.3	10.2	0.3	-1.2	-3.1	0.2	-3.2
Lung cancer (father)	1.0	1.1	2.0	0.4	-0.3	-1.3	1.4	-1.4
Birth weight	1.0	2.1	5.7	-1.4	0.4	-2.4	-1.2	-1.1
High blood pressure (siblings)	1.0	1.4	2.9	1.4	0.4	-1.7	-0.8	-1.2
Body fat percentage	1.0	4.0	12.0	-0.0	-0.6	-2.7	-0.6	-3.5
Leg fat percentage (right)	1.0	3.7	8.9	0.7	-0.5	-3.0	-0.6	-3.0
Eye problems/disorders: None of the above	1.0	1.2	2.9	-0.2	1.7	0.1	-1.4	-1.1
Illnesses of siblings: Diabetes	1.0	1.2	3.7	0.9	1.1	1.9	0.2	0.7
Loneliness, isolation	1.0	1.4	6.4	0.4	-0.1	2.5	-0.7	0.3
Qualifications: nursing, teaching	1.0	1.6	3.8	-1.0	-0.4	-1.9	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.7	1.1	0.9	0.5	2.2	1.8
Medication: Paracetamol	1.0	1.6	4.5	1.5	-2.1	0.9	-0.4	-0.4
Leg fat percentage (left)	1.0	3.7	10.0	0.3	-1.1	-2.6	-0.4	-3.2
Number of operations (self-reported)	1.0	1.4	5.7	1.1	-2.4	-0.2	0.2	0.5
Average weekly beer plus cider intake	1.0	1.5	4.5	1.3	1.1	-0.0	-2.1	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	4.0	-1.0	2.0	0.2	-0.1	1.0
Coronary Artery Disease (CAD)	0.9	1.1	3.2	1.8	-0.7	-0.6	0.6	1.0
Lung FEV1/FVC ratio	0.9	4.7	9.9	-2.2	-2.5	-3.1	1.1	-1.2
Taking other prescription medications	0.9	1.5	3.5	1.9	-1.8	-0.6	0.0	0.4
Body mass index (BMI)	0.9	3.7	8.1	0.5	-1.5	-2.8	0.3	-2.8
Financial difficulties in last 2 years	0.9	1.2	3.8	2.0	-0.2	0.4	1.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	13.0	0.4	0.6	-0.4	3.6	1.2
Arm fat mass (right)	0.9	3.5	8.9	0.3	-0.7	-2.9	-0.2	-3.0
Breastfed as a baby	0.9	1.1	2.3	1.5	-1.1	-0.1	0.0	1.4
Medication: Paracetamol	0.9	1.5	4.3	1.0	-2.1	1.3	0.1	-0.6
Comparative body size at age 10	0.9	2.5	6.1	0.7	-0.8	-2.2	0.7	-2.5
Age at first live birth	0.9	1.6	3.3	0.7	0.2	0.9	1.8	1.8
Medication for pain relief, constipation, heartburn	0.9	1.5	4.6	-0.4	2.1	-0.4	1.6	0.2
Leg pain on walking	0.9	1.1	2.1	1.4	-0.6	0.5	1.5	0.9
Medication: Aspirin	0.9	1.2	3.3	1.3	-0.6	0.4	-0.8	1.8
Average weekly red wine intake	0.9	1.3	5.3	0.4	-2.3	0.3	0.9	0.0
Eye problems/disorders: Cataract	0.9	1.1	2.1	0.6	-0.7	1.3	0.8	1.4
Medication for cholesterol	0.9	1.4	2.4	1.5	-1.2	-0.3	1.4	1.1
Medication: Aspirin	0.9	1.1	3.2	1.1	-0.1	0.3	-1.0	1.8
Arm fat mass (left)	0.9	3.8	9.3	0.2	-0.9	-3.0	-0.1	-3.1
Wears glasses or contact lenses	0.9	1.0	2.5	1.6	-0.7	0.4	-0.3	1.4
Alcohol drinker status: Never	0.9	1.0	3.7	1.9	0.9	0.8	-0.1	0.0
Supplements: Calcium	0.9	1.0	1.8	0.7	-1.2	-1.3	-0.6	0.9
Bipolar Disorder or Schizophrenia	0.8	1.9	3.4	0.5	0.7	1.6	-1.8	1.6
Crohns Disease (2012)	0.8	1.3	3.8	2.0	0.7	-0.3	-1.4	0.1
HDL Cholesterol	0.8	1.3	4.2	-2.0	0.3	0.4	-0.8	-1.2
Lung FVC	0.8	4.0	8.5	1.1	0.5	1.6	2.7	2.9
Sensitivity / hurt feelings	0.8	1.4	3.3	-0.2	-1.8	0.3	-1.7	-1.0
Medication for hormone replacement therapy	0.8	0.9	3.3	-1.0	0.1	-0.2	-1.8	-0.0
Alcohol usually taken with meals	0.8	1.3	6.0	0.4	-2.4	-0.6	-0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.2	-0.2	-1.5	-1.8	0.5	-1.7
Qualifications: None of the above	0.8	1.8	4.5	2.1	0.9	1.1	1.4	0.3
Heart attack	0.8	1.0	3.6	-1.0	1.9	0.1	-0.1	0.8
Weight	0.8	3.8	9.6	0.4	-0.9	-3.1	0.3	-2.9
Alcohol intake versus 10 years previously	0.8	1.2	4.5	0.9	-0.8	0.3	-2.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	-0.4	-1.3	-0.8	1.3	-1.5
Depression (self-reported)	0.8	0.9	3.0	-1.1	-0.4	1.7	0.2	0.5
Prospective memory result	0.8	1.0	1.7	1.3	-0.2	0.3	1.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	11.2	-0.1	0.8	0.3	3.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.6	1.3	-1.9	0.8	0.2	-0.6
Peak expiratory flow (PEF)	0.8	1.8	5.7	0.6	-0.9	-0.9	2.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.6	1.1	-1.1	0.3	-0.6	1.3
Health satisfaction	0.8	1.0	3.5	-1.9	-0.3	-0.9	-0.2	-0.8
Medication: Allopurinol	0.8	1.0	3.9	-2.0	-0.7	0.4	0.7	-0.5
Heart disease (mother)	0.8	1.0	3.2	1.3	0.3	1.8	0.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.2	-0.1	0.8	-0.7	-1.3	-1.5
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.5	-1.2	-1.4	-0.8	0.5
Financial situation satisfaction	0.8	1.0	2.0	-0.1	1.0	-1.4	0.2	-1.4
Risk taking	0.8	1.2	4.4	1.0	0.3	-0.4	2.1	-0.2
Commuting to job workplace: Cycle	0.8	1.0	2.8	0.9	0.8	0.1	-1.7	0.8
Basal cell carcinoma (self-reported)	0.8	1.0	2.5	1.2	-0.5	0.4	-1.6	0.9
Bipolar Disorder (2018)	0.7	1.0	2.9	0.2	-0.4	1.2	-0.7	1.7
Alzheimer’s Disease (in father)	0.7	0.8	3.1	-1.8	0.7	0.4	0.3	-0.4
Ovarian Cancer	0.7	1.0	1.8	-1.2	0.5	1.1	1.4	-0.5
Triglycerides	0.7	1.1	3.1	-0.7	1.8	-0.4	-0.1	1.3
BMI	0.7	4.0	9.7	0.9	-2.0	-3.1	0.2	-2.4
Supplements: Zinc	0.7	0.7	1.6	0.3	0.8	0.6	-0.9	-1.3
Medication: Co-codamol	0.7	0.8	3.4	-0.2	-0.4	0.2	0.6	1.9
Maternal smoking around birth	0.7	1.1	4.2	0.4	1.0	0.0	2.0	-0.1
Medication: Atenolol	0.7	0.9	1.7	-1.3	-0.7	-0.7	1.0	-0.8
Had other major operations	0.7	0.8	3.4	1.8	-0.3	0.5	-0.5	0.2
Diabetes (self-reported)	0.7	1.1	3.5	1.1	-0.5	0.7	0.4	1.9
Arm fat percentage (right)	0.7	2.9	8.5	0.1	-0.6	-2.4	-0.6	-2.9
Pulse rate	0.7	1.1	2.6	-1.6	0.5	0.6	1.5	0.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	-0.4	-0.4	0.9	-0.9	-1.3
Exposure to tobacco smoke at home	0.7	0.7	1.6	1.1	0.0	-0.7	1.3	-0.7
Pulse wave reflection index	0.7	0.9	2.2	0.2	-1.0	1.5	-0.2	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.6	7.9	0.6	1.3	1.0	2.8	1.5
Alcohol intake frequency.	0.7	1.6	6.3	2.5	0.7	0.6	-0.9	-0.3
Suffer from ‘nerves’	0.7	1.1	2.6	-1.3	-0.2	1.0	-1.6	0.4
Family relationship satisfaction	0.7	0.8	2.5	0.4	-0.1	1.2	-1.6	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	0.8	1.5	0.4	-0.8	0.5
Arm fat percentage (left)	0.7	2.8	8.1	-0.1	-0.4	-2.4	-0.5	-2.8
Mood swings	0.7	1.3	3.6	0.8	-1.1	-0.5	-0.9	-1.9
Diabetes diagnosed by doctor	0.7	1.1	3.1	0.4	-0.8	1.1	0.7	1.8
Mineral and other dietary supplements	0.7	1.0	3.0	-1.1	0.0	-0.2	1.7	-0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	0.9	-0.5	1.5	0.7	0.7
Medication: Atorvastatin	0.7	0.9	3.2	-0.5	-1.8	-0.8	-0.3	-0.5
Diastolic blood pressure, automated reading	0.7	2.3	8.3	1.0	2.9	1.2	0.7	-0.5
Myopia	0.7	1.0	2.0	1.4	-1.0	-0.5	-1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	0.8	1.0	0.4	-1.5	-0.1
Schizophrenia (2018)	0.6	1.2	2.6	0.5	1.2	1.1	-1.6	0.7
Worry (Nagel 2018)	0.6	1.2	3.3	-0.1	-0.3	1.6	-0.3	1.8
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	0.3	-1.6	-0.9	-0.4	-0.1
Crohns Disease (2017)	0.6	1.4	3.8	1.9	1.3	-0.7	1.0	0.4
Blood Red Count	0.6	5.4	10.1	1.8	0.2	2.4	3.2	2.8
Number of treatments/medications taken	0.6	1.1	3.1	0.7	-1.3	-0.6	-1.8	0.1
Diabetes (mother)	0.6	0.7	1.8	0.4	1.3	1.2	-0.4	-0.0
Average weekly fortified wine intake	0.6	0.7	2.8	-1.7	-0.1	-0.7	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	-0.3	-1.3	0.7	0.9	0.5
Fluid intelligence score	0.6	1.3	6.3	-2.5	-0.1	0.1	-0.1	-0.3
Worrier / anxious feelings	0.6	1.1	2.6	-1.4	-1.6	-0.0	-0.9	-0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.9	-1.2	-1.4	-0.8	-1.7	0.3
Illnesses of mother	0.6	0.7	1.3	-0.8	1.1	-1.1	-0.6	-0.4
Length of working week for main job	0.6	0.6	1.9	-1.4	0.7	0.3	-0.4	-0.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	1.4	1.2	1.4	0.4	0.1
Pulse wave peak to peak time	0.6	0.7	1.9	0.3	0.6	-0.7	0.8	1.4
Medication: Seretide 50 evohaler	0.6	0.7	2.0	-0.6	-1.4	-0.4	-0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.6	-0.6	-0.3	1.6	0.5	0.6
Had major operations	0.6	0.7	1.6	0.8	-1.3	-0.2	0.7	0.7
Breast cancer (self-reported)	0.6	0.7	1.6	-0.3	-1.3	-1.0	-1.0	0.1
Miserableness	0.6	1.1	2.3	0.5	-1.3	-0.1	-1.2	-1.5
Depressed Affect (Nagel 2018)	0.5	1.1	3.0	-0.2	-1.4	-0.3	-0.5	-1.7
Depression (Nagel 2018)	0.5	0.7	2.1	-0.5	-1.4	0.6	0.0	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	4.2	-0.2	-2.0	0.8	-0.7	-0.1
Breast Cancer	0.5	1.3	3.5	-1.5	0.3	0.7	1.9	0.1
Body Mass Index (BMI) (2010)	0.5	0.6	3.1	-0.2	-0.1	-1.7	-0.4	-0.0
Allergy or Eczema	0.5	1.4	3.9	2.0	-0.2	1.2	0.6	1.0
Cardiovascular Disease	0.5	1.7	5.8	0.9	2.4	0.9	-0.1	1.1
Hand grip strength (left)	0.5	1.2	5.3	-0.4	0.3	-0.3	2.3	0.8
Relative age of first facial hair	0.5	1.0	2.1	0.6	-0.3	-1.0	-1.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	-0.7	-0.6	-1.2	0.6	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.8	1.3	-0.4	1.9	0.1	0.4
Multivitamins +/- minerals	0.5	0.6	1.7	1.3	-0.2	1.0	0.0	0.6
Number of incorrect matches in round	0.5	0.8	3.3	1.8	0.2	-0.1	0.0	0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.9	0.4	-0.8	0.7	1.4	0.8
Mouth/teeth dental problems	0.5	0.8	2.8	-0.7	0.6	-0.6	-0.3	-1.7
Pain all over the body in last month	0.5	0.5	0.8	0.4	0.7	-0.8	-0.9	-0.7
Neuroticism score	0.5	1.0	1.9	0.9	-1.3	1.4	-0.6	-0.2
Impedance of arm (left)	0.5	2.3	4.5	-1.8	2.1	1.1	-1.6	-0.3
Loud music exposure frequency	0.5	0.5	2.3	-1.5	-0.2	-0.3	0.1	0.3
Headache pain in last month	0.5	0.9	2.7	-0.3	-1.6	-0.4	-0.9	-0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	-0.5	1.2	1.0	0.2	0.4
Exposure to tobacco smoke outside home	0.5	0.7	2.4	1.5	0.5	-0.5	-0.2	-0.7
Shortness of breath walking on level ground	0.5	0.6	0.9	0.7	-0.6	-1.0	0.8	-0.6
Qualifications: College or University degree	0.5	1.6	5.8	-2.4	-1.1	-0.7	0.6	0.5
Mean time to correctly identify matches	0.5	0.9	1.8	0.7	1.4	0.2	-1.1	1.0
Osteoarthritis (self-reported)	0.5	0.7	1.6	1.3	-0.1	0.6	0.2	1.2
Medication: Gliclazide	0.5	0.5	2.1	1.4	0.1	0.3	-0.6	0.4
Hearing aid user	0.5	0.5	2.0	0.4	-0.6	1.4	-0.1	0.0
Mother’s age at death	0.5	0.6	1.0	-0.8	-1.0	1.0	0.7	0.4
Medication: Lisinopril	0.5	0.7	2.7	-1.6	0.3	-0.1	-0.8	-0.5
Age started oral contraceptive pill	0.5	0.6	1.0	-0.9	-1.0	-0.1	0.9	0.6
Ever depressed for a whole week	0.5	0.6	1.7	-0.3	0.5	0.7	1.3	-0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.2	1.0	1.0	-0.9	1.1	0.6
Neuroticism (2016)	0.4	0.5	1.1	0.3	-1.0	1.1	-0.7	0.1
Blood Eosinophil Count	0.4	3.1	9.4	-0.4	0.7	2.3	0.2	3.1
Respiratory disease	0.4	0.9	2.3	1.5	-0.1	1.1	-0.2	1.0
Neuroticism	0.4	0.8	3.5	0.8	-1.9	0.4	-0.0	-0.0
Chronotype (morning person)	0.4	0.9	3.1	0.9	0.3	0.1	0.6	1.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.4	-1.2	0.3	0.3	-1.1
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	0.2	-0.1	-0.7	-0.5	-1.1
Hand grip strength (right)	0.4	1.2	4.7	-0.9	-0.2	-0.4	2.2	-0.3
Fed-up feelings	0.4	0.7	1.4	1.0	-1.2	-0.1	-0.5	-1.0
Age when periods started (menarche)	0.4	1.1	2.9	1.7	-0.9	-0.6	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	-0.2	-0.7	-0.8	1.0	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.0	-0.5	-1.4	-0.5	-0.7	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	0.5	0.5	-0.1	-1.1	-0.7
Medication: Ramipril	0.4	0.5	0.8	-0.9	-0.7	0.5	-0.4	-0.9
Impedance of arm (right)	0.4	2.0	3.9	-1.3	2.0	1.2	-1.7	-0.2
Father’s age at death	0.4	0.6	1.2	1.1	-0.6	-0.4	-0.9	0.4
Falls in the last year	0.4	0.6	1.0	0.5	-1.0	1.0	0.4	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.2	1.1	-0.0	1.5	0.2	0.4
Arm fat-free mass (right)	0.4	2.2	6.2	0.5	-0.6	-2.5	1.3	-1.5
Arm predicted mass (right)	0.4	2.3	6.6	0.7	-0.7	-2.6	1.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.9	0.3	1.2	-0.4	0.9	-1.4
Long-standing illness, disability or infirmity	0.4	0.6	1.7	0.2	-0.4	-0.4	-1.3	-0.9
Friendships satisfaction	0.4	0.6	1.4	0.2	-0.8	0.4	-1.2	-0.8
Back pain experienced in last month	0.4	0.6	1.4	-0.6	0.4	0.7	0.9	1.2
Guilty feelings	0.4	0.5	1.3	0.8	-1.1	0.4	0.5	-0.6
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	0.7	-0.5	0.7	-0.8	0.5
Ever smoked	0.4	0.6	1.5	-0.1	1.2	-0.6	-1.0	-0.6
Basal metabolic rate	0.4	2.2	6.9	0.5	-0.6	-2.6	0.8	-1.7
Arm fat-free mass (left)	0.4	2.2	5.8	1.1	-0.7	-2.4	1.1	-1.5
Unable to work because of sickness or disability	0.4	0.5	2.1	0.2	0.2	0.6	1.5	-0.3
Alcohol drinker status: Previous	0.4	0.4	0.8	0.6	0.9	0.1	-0.1	0.9
Arm predicted mass (left)	0.4	2.2	4.9	1.1	-1.0	-2.2	1.4	-1.3
Ulcerative Colitis (UC)	0.3	0.5	1.1	-0.3	0.4	-0.7	1.1	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	-1.4	-0.2	0.6	0.4	1.0
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	-0.6	0.7	0.1	0.1
Fasting Glucose	0.3	0.4	1.1	-0.2	-1.1	0.4	0.0	-0.7
Schizophrenia (2014)	0.3	0.6	1.0	0.5	0.5	1.0	-1.0	0.9
Hypothyroidism (self reported)	0.3	0.7	2.9	0.8	-0.0	1.7	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	0.5	0.0	1.0	0.9	1.0
Medication: Metformin	0.3	0.4	1.0	-0.3	-0.7	0.2	-0.5	1.0
Leg fat-free mass (left)	0.3	1.7	5.8	0.2	-0.2	-2.4	0.4	-1.6
Current tobacco smoking	0.3	0.5	1.4	-0.3	1.2	-0.7	-0.1	-0.7
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.8	-0.9	-0.1	-0.7	-0.3
Medication: Levothyroxine sodium	0.3	0.6	1.9	0.7	0.1	1.4	0.7	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.8	-0.2	0.8	0.4	0.1
High blood pressure (mother)	0.3	0.4	0.7	0.4	-0.7	0.8	0.1	0.7
Leg predicted mass (left)	0.3	1.8	6.0	0.2	-0.2	-2.4	0.5	-1.6
Nervous feelings	0.3	0.5	1.2	-0.1	-0.3	1.1	-0.5	1.1
Had menopause	0.3	0.3	0.5	-0.7	0.7	-0.4	0.7	0.1
Medication: Simvastatin	0.3	0.5	1.6	-0.7	1.3	0.2	-0.4	0.4
Illnesses of siblings	0.3	0.5	0.9	-0.9	-0.8	0.6	-0.1	0.7
Trunk fat-free mass	0.3	1.5	5.5	0.6	-0.6	-2.3	0.9	-0.8
Medication: Lansoprazole	0.3	0.4	1.2	0.5	-0.3	-1.1	0.4	-0.0
Trunk predicted mass	0.3	1.5	5.4	0.7	-0.6	-2.3	0.8	-0.8
Tense / ‘highly strung’	0.3	0.5	1.1	0.4	-0.5	1.1	-0.6	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.0	1.4	0.1	0.4	-0.6	1.1
Birth weight of first child	0.3	0.6	1.6	-0.8	1.2	-0.3	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	0.5	0.9	1.1	0.3	0.2
Worry too long after embarrassment	0.3	0.4	1.0	-0.9	-1.0	0.2	-0.5	-0.3
Medication: Blood pressure	0.3	0.5	0.8	-0.9	-0.6	-0.8	0.3	-0.8
Medication: Ibuprofen	0.3	0.4	1.4	0.4	-1.2	-0.3	0.5	0.0
Pulse rate, automated reading	0.3	0.9	3.1	0.4	0.2	0.3	1.8	0.9
Number of full sisters	0.3	0.4	1.3	0.6	0.1	1.1	0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.1	0.9	0.2	0.4	1.0
Hypertension (Self-reported)	0.3	0.8	2.6	1.6	0.6	0.7	-0.6	0.0
Smoking status: Previous	0.3	0.5	1.0	0.6	0.3	0.7	0.7	1.0
Whole body fat-free mass	0.3	1.7	5.8	0.4	-0.6	-2.4	0.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.2	0.4	-1.1	-0.2	-0.5	1.0
Smoking status: Current	0.3	0.5	1.0	0.5	1.0	-0.9	-0.3	-0.6
Whole body water mass	0.3	1.7	5.4	0.5	-0.5	-2.3	0.9	-1.2
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-1.0	-0.1	-0.2	0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.4	-0.4	0.1	-1.1	0.4
Heart disease (siblings)	0.3	0.4	1.0	0.7	-0.2	-1.0	-0.5	-0.4
Impedance of whole body	0.3	1.5	3.5	-1.0	1.9	0.9	-1.3	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.2	-1.8	-0.1	0.1	-0.0	0.7
Alzheimer’s Disease (including proxy)	0.2	0.4	1.3	-0.1	-0.7	-0.2	0.1	-1.1
Reaction Time	0.2	0.5	1.3	0.2	1.1	-0.2	-1.0	0.1
Lupus	0.2	0.2	0.5	0.7	-0.7	-0.1	0.3	-0.2
Ulcerative Colitis	0.2	0.3	0.8	-0.3	-0.5	-0.9	-0.4	-0.1
Smoking Status	0.2	0.4	0.8	-0.0	0.9	-0.5	-0.8	-0.5
Tanning	0.2	2.3	5.2	-1.5	0.7	1.7	2.3	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.3	-0.5	-0.8	-0.6	-0.3
High blood pressure	0.2	0.5	2.0	1.4	0.2	0.5	-0.6	-0.3
Supplements: Glucosamine	0.2	0.3	0.5	0.3	-0.5	-0.7	-0.7	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.6	-0.5	0.2	0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.9	0.9	-0.0	0.2	0.0
Time employed in main current job	0.2	0.3	0.6	-0.6	0.8	0.5	-0.3	-0.4
Number of live births	0.2	0.3	0.9	1.0	0.1	-0.0	0.6	-0.4
Noisy workplace	0.2	0.2	0.8	-0.3	0.9	-0.4	-0.4	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.1	-0.3	-1.0	-0.4	-0.8
Asthma	0.2	0.4	0.9	1.0	-0.9	-0.3	-0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.1	-0.7	-0.4	0.3	0.5
Medication: Amlodipine	0.2	0.3	0.6	-0.8	-0.7	-0.3	-0.5	-0.2
Number of children fathered	0.2	0.3	0.5	-0.7	0.3	0.1	0.5	0.6
Angina (self-reported)	0.2	0.2	0.4	0.4	0.0	-0.1	-0.6	0.7
Comparative height size at age 10	0.2	1.2	5.1	-0.5	2.3	-0.1	-0.8	-0.2
Leg fat-free mass (right)	0.2	1.3	3.4	-0.0	-0.4	-1.8	0.6	-1.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.7	0.0	-0.3	0.7	0.4
Leg predicted mass (right)	0.2	1.3	3.4	-0.1	-0.4	-1.8	0.7	-1.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	1.1	-0.6	-0.1	-0.3	0.5
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.3	-0.2	-0.4	-0.4	-0.7
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	0.3	0.0	-0.5	-0.5
Pain experienced in last month	0.2	0.4	1.4	0.3	1.2	0.4	0.2	0.2
Mean Putamen Volume	0.1	0.1	0.3	0.1	-0.6	0.1	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.6	0.1	-0.1	0.3	0.3
Heel T-Score	0.1	0.8	3.0	0.2	1.7	-0.3	0.8	-0.3
Waist Hip Ratio (WHR)	0.1	0.6	1.7	-0.0	-0.7	-0.5	-1.3	-0.6
Hair Pigment	0.1	2.1	8.4	1.2	0.0	-0.7	-2.9	-0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.0	-0.7	0.2	0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.1	-0.1	-0.4	0.2	0.5
Angina	0.1	0.2	0.5	0.4	-0.1	-0.0	-0.5	0.7
Diabetes (father)	0.1	0.1	0.2	-0.1	0.4	0.2	0.4	-0.4
Impedance of leg (right)	0.1	0.6	2.5	-0.2	1.6	-0.0	-0.6	-0.3
Relative age voice broke	0.1	0.1	0.3	0.3	-0.4	0.4	0.5	-0.0
Impedance of leg (left)	0.1	0.4	0.6	-0.6	0.8	0.6	-0.5	-0.6
Past tobacco smoking	0.1	0.3	0.6	-0.8	-0.7	0.5	0.2	0.1
Allergy	0.1	0.3	0.8	-0.8	0.2	-0.9	0.3	0.1
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.5	-0.3	-0.6	-0.4	0.2
Standing height	0.1	0.7	1.6	-0.2	1.1	-1.3	-0.0	-0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	0.3	0.0	0.3	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	-0.5	-0.1	0.1	-0.4	0.7
Overall health rating	0.1	0.1	0.3	-0.0	-0.0	-0.3	-0.5	-0.5
Knee pain experienced in last month	0.1	0.2	0.6	-0.3	0.8	0.1	-0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.5	0.1	-0.2	0.2	-0.5
Asthma (self-reported)	0.1	0.3	0.9	0.6	-0.9	0.1	-0.3	0.3
Medication: Blood pressure	0.1	0.2	0.4	-0.1	-0.2	0.2	-0.6	-0.7
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.2	0.3	-0.8	0.3	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.8	-0.2	-0.3	0.8	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.2	0.4	-0.0	-0.3	-0.1	0.0
Height	0.0	0.4	1.8	0.2	-0.5	-1.4	0.4	-0.1
Sitting height	0.0	0.3	0.5	-0.2	-0.6	-0.7	0.5	-0.6

Hub : Genes

S1PR3

Models

Trait associations