Hub : Genes

SALL4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Squamous Cell Carcinoma	0.0455	0.0205	2.3e-03	0.000	0.024	0.024	NA	0.008	0.33000	7.9e-04	8.2e-04	NA	3.5e-02
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.1040	0.0470	3.5e-03	0.000	0.032	0.026	NA	0.027	0.29000	3.1e-03	6.6e-03	NA	6.3e-03
3	TCGA	Prostate Adenocarcinoma	0.0682	0.0272	3.6e-05	0.029	0.054	0.047	NA	0.056	0.00046	2.4e-06	1.1e-05	NA	1.7e-06
4	TCGA	Thyroid Carcinoma	0.0560	0.0270	3.6e-04	0.013	0.035	0.040	NA	0.031	0.01700	2.4e-04	8.2e-05	NA	4.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.7	2.9	1.7	1.3	1.4	0.1
Bipolar Disorder or Schizophrenia	1.6	3.9	5.0	2.1	2.2	2.0	1.6
Depressed Affect (Nagel 2018)	0.6	1.3	3.6	-1.9	-0.7	-0.7	-0.8
Depression (Nagel 2018)	1.0	1.5	2.3	-1.5	-0.5	-1.5	-1.2
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.5	-0.5	2.3	0.5	1.4
Neuroticism (Nagel 2018)	1.5	3.5	5.7	-2.2	-1.3	-2.4	-1.3
Schizophrenia (2018)	1.3	2.7	3.8	1.2	1.8	1.4	1.9
Schizophrenia vs Biploar Disorder	0.5	0.7	2.4	-1.6	-0.1	-0.6	0.1
Worry (Nagel 2018)	1.5	3.2	4.7	-2.2	-2.1	-1.9	-0.6
Alzheimer’s Disease (in mother)	0.7	0.8	2.9	-0.2	-0.5	-1.7	0.2
Alzheimer’s Disease (in father)	1.4	1.5	5.5	-0.5	2.3	-0.5	0.3
Alzheimer’s Disease (including proxy)	0.8	1.1	3.3	0.3	1.8	-0.7	0.8
Crohns Disease (2017)	0.4	0.8	2.5	-1.6	0.5	-0.5	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-1.0	0.8	-0.1	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.1	0.2	1.0	-0.0	1.0
Major Depression (MDD)	0.6	0.8	2.1	-0.2	0.2	-0.9	-1.5
Reaction Time	1.1	2.1	3.9	2.0	2.0	0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.0	0.4	2.5	0.3	1.1
Breast Cancer	0.4	1.0	2.2	-1.2	0.4	-1.5	-0.4
Ovarian Cancer	1.4	1.9	6.4	2.5	-0.2	0.9	0.6
Prostate Cancer	0.6	0.8	1.2	-1.1	-0.7	1.1	-0.7
Age at First Birth	1.9	2.8	6.6	2.6	0.6	1.4	1.5
Bipolar Disorder (2011)	1.7	1.7	4.8	2.2	0.3	0.8	1.0
Body Mass Index (BMI) (2010)	2.3	3.2	5.8	-2.4	-2.1	-0.8	-1.4
Coronary Artery Disease (CAD)	0.6	0.7	1.4	0.8	-0.5	1.2	-0.8
Crohns Disease (2012)	0.3	0.4	1.0	-1.0	0.5	-0.3	-0.6
Mean Putamen Volume	0.6	0.7	1.7	-0.9	1.3	-0.3	0.1
Fasting Glucose	0.6	0.7	1.2	0.8	0.6	1.1	0.9
HbA1C	1.3	1.5	2.0	-1.4	-1.4	-0.7	-1.1
HDL Cholesterol	3.2	5.4	9.6	2.6	0.8	2.2	3.1
LDL Cholesterol	0.2	0.3	0.5	0.2	-0.6	-0.7	0.6
Lupus	0.2	0.3	0.6	0.3	0.8	0.6	0.1
Neuroticism (2016)	0.4	0.6	1.6	-0.6	-0.5	-1.3	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.5	1.1	0.2	-0.1
Rheumatoid Arthritis	1.7	2.4	3.8	-1.9	1.6	-1.7	-0.5
Schizophrenia (2014)	0.9	1.9	2.2	1.2	1.3	1.5	1.5
Triglycerides	0.2	0.4	0.9	0.2	-0.7	0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.3	0.4	1.1	0.6
Ulcerative Colitis	0.6	0.9	1.8	-1.2	1.3	0.7	-0.1
Blood Eosinophil Count	0.3	2.0	4.0	-2.0	-0.8	0.1	-1.9
Blood Platelet Count	0.2	1.9	4.2	1.4	0.8	2.0	0.9
Blood Red Count	0.3	2.6	5.7	-1.8	-1.0	0.5	-2.4
Blood White Count	0.8	6.0	12.6	-2.6	-1.3	-1.7	-3.5
Heel T-Score	0.1	0.8	2.1	1.1	1.4	0.2	-0.1
BMI	2.4	14.1	26.2	-5.1	-1.8	-2.3	-4.6
Height	0.3	6.7	14.5	3.8	1.9	2.3	1.8
Waist Hip Ratio (WHR)	0.1	0.5	1.3	-0.8	-1.1	0.3	-0.0
Systolic Blood Pressure	0.2	1.2	2.6	1.5	-1.6	0.2	0.5
Smoking Status	0.6	1.5	2.6	-1.1	-1.6	-0.6	-1.3
Allergy or Eczema	0.9	2.3	5.1	-2.3	-0.9	-0.3	-1.8
Cardiovascular Disease	0.4	1.2	2.6	0.8	-1.2	1.6	-0.3
Hypothyroidism (self reported)	0.4	1.0	2.1	-1.2	-1.5	-0.5	-0.2
Respiratory disease	0.3	0.8	1.6	-0.2	0.6	1.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.6	-2.1	0.7	-0.3	0.2
Lung FEV1/FVC ratio	0.1	0.7	1.9	0.1	0.9	1.4	0.4
Lung FVC	0.6	3.2	9.9	-0.2	-1.7	0.2	3.1
Neuroticism	0.9	2.2	3.8	-1.9	-1.2	-1.6	-0.9
Chronotype (morning person)	0.4	0.9	1.7	0.5	-0.6	1.1	1.3
Hair Pigment	0.1	3.1	6.2	-1.5	1.3	-1.5	-2.5
Tanning	0.1	1.3	3.3	1.8	-0.2	1.3	-0.3
Hand grip strength (left)	0.3	0.7	1.1	-1.0	-0.9	-0.5	-0.8
Number of treatments/medications taken	1.9	3.4	4.9	-2.2	-1.7	-2.0	-1.2
Average weekly spirits intake	0.5	0.7	1.1	-0.7	0.1	-1.0	-1.0
Sensitivity / hurt feelings	2.0	3.4	5.6	-2.2	0.0	-1.8	-2.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.7	-0.0	-0.9	0.5
Hearing difficulty/problems: Yes	3.9	6.0	11.0	-3.3	-1.6	-2.9	-1.4
Relative age of first facial hair	1.6	3.3	5.7	2.4	0.8	2.4	1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	-0.6	-1.1	-0.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.7	0.1	-1.3	0.1	-0.1
Ever had hysterectomy (womb removed)	1.8	2.0	3.7	-1.9	-0.7	-0.3	-1.9
Systolic blood pressure, automated reading	0.8	2.4	4.6	0.9	-1.9	-2.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.5	-0.1	0.4	-0.6
Angina	0.9	1.1	3.6	0.2	-1.9	0.1	-1.0
Medication for hormone replacement therapy	4.4	4.9	8.0	-2.8	-1.9	-2.4	-1.5
Vitamin and mineral supplements	1.5	2.0	3.2	1.0	-0.9	1.7	1.8
Supplements: Zinc	1.7	1.8	4.5	-0.6	0.8	1.3	-2.1
Medication: Co-codamol	0.3	0.4	0.9	0.0	-0.8	0.9	0.1
Medication: Metformin	1.2	1.7	3.0	-1.4	-1.7	-0.2	1.3
Diabetes (father)	0.2	0.3	0.5	-0.3	0.4	-0.6	0.7
Diabetes (mother)	0.4	0.5	1.2	-0.2	-1.1	0.1	0.7
Severe depression (siblings)	0.6	0.7	1.7	-0.1	-0.1	1.3	0.9
Pack years adult smoking proportion	3.7	5.7	14.4	-3.8	-0.6	-1.6	-2.3
Impedance of leg (right)	0.6	2.8	7.5	1.7	-0.9	-0.1	2.7
Leg fat-free mass (left)	0.1	0.6	1.6	-1.3	0.3	0.2	-0.8
Trunk fat percentage	0.9	3.5	5.9	-2.2	-2.4	-1.7	-0.5
Hand grip strength (right)	0.1	0.2	0.6	0.2	-0.8	-0.1	0.2
Townsend deprivation index at recruitment	1.2	1.7	5.5	1.1	0.1	2.3	-0.3
Current tobacco smoking	4.2	6.9	14.2	-3.8	-0.3	-2.2	-2.9
Average weekly fortified wine intake	0.8	0.9	1.7	1.3	1.3	-0.5	-0.2
Maternal smoking around birth	0.5	0.8	2.8	-0.1	-1.7	-0.0	-0.5
Fed-up feelings	0.5	0.9	2.6	-1.6	-0.3	-0.4	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.8	-1.7	-0.9	-0.6	-1.7
Relative age voice broke	2.7	4.1	6.9	1.3	2.6	2.2	1.8
Taking other prescription medications	2.2	3.4	5.4	-2.3	-2.3	-1.2	-1.3
Age when periods started (menarche)	0.6	1.3	1.9	0.5	1.3	1.2	1.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-1.4	1.0	0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.4	0.5	-0.0	-1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-1.0	0.5	-0.2	0.7
Qualifications: CSEs or equivalent	1.3	1.7	2.7	-1.2	-1.6	-1.1	-1.2
Serious illness, injury or assault to yourself	1.5	1.8	3.5	-1.9	-1.5	-1.0	-0.8
High blood pressure	0.7	2.0	4.8	1.7	-2.2	0.4	0.2
Hayfever, allergic rhinitis or eczema	1.3	2.9	7.4	-2.7	-1.5	-0.1	-1.5
Multivitamins +/- minerals	2.2	2.8	6.5	-0.6	1.3	-1.6	-2.5
Stomach or abdominal pain in last month	0.8	1.0	2.2	-0.9	1.0	1.5	0.4
Supplements: Glucosamine	2.2	2.9	5.6	-1.6	0.1	-1.8	-2.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	0.3	0.0	-0.9	-0.1
Medication: Atenolol	1.7	2.1	4.2	2.0	-1.9	0.8	0.1
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.2	0.2	0.6	0.8
Sitting height	0.7	4.7	12.0	3.5	1.1	0.4	2.3
Chronic bronchitis/emphysema (father)	2.7	3.2	9.4	-0.7	-3.1	-1.0	-1.4
High blood pressure (mother)	0.5	0.7	1.3	0.8	-1.1	0.5	0.7
Body mass index (BMI)	2.5	10.6	19.7	-4.4	-2.3	-2.4	-3.4
Impedance of leg (left)	0.5	2.4	4.8	1.8	-0.8	0.8	2.2
Leg predicted mass (left)	0.1	0.7	1.8	-1.3	0.2	0.0	-1.0
Trunk fat mass	0.7	2.9	4.7	-2.2	-2.0	-1.4	-0.9
Waist circumference	1.6	6.0	12.5	-3.5	-2.1	-1.3	-2.4
Number of incorrect matches in round	0.1	0.2	0.3	-0.4	-0.3	-0.4	-0.5
Past tobacco smoking	0.9	1.6	3.5	-1.7	1.9	0.2	-0.2
Alcohol usually taken with meals	0.5	0.8	2.2	0.9	1.5	-0.1	0.5
Nervous feelings	1.4	2.5	4.6	-2.1	-0.8	-2.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.5	-0.3	-1.6	-0.4	-0.6
Hearing difficulty/problems with background noise	1.2	1.9	4.1	-1.7	-0.7	-2.0	0.0
Hair/balding pattern: Pattern 2	1.7	2.2	4.9	1.8	0.1	0.8	2.2
Had menopause	0.8	1.0	2.7	0.1	-1.0	-1.6	-0.3
Had other major operations	2.7	3.3	8.1	-2.1	0.4	-2.9	-0.7
Forced vital capacity (FVC)	2.0	7.6	15.7	3.5	-0.1	1.5	4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	0.2	1.1	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.2	-1.5	-0.6	-1.5	-0.1
Qualifications: None of the above	3.1	6.7	13.8	-3.7	-1.3	-2.3	-2.5
Financial difficulties in last 2 years	1.0	1.3	3.8	-2.0	0.1	-0.4	-1.1
Mouth/teeth dental problems	0.6	1.0	2.2	-0.3	0.7	-1.0	-1.5
Heart attack	0.4	0.6	2.0	-0.3	-0.4	0.3	-1.4
Allergy	2.4	5.6	10.4	3.2	1.7	1.0	2.9
Pain all over the body in last month	2.2	2.4	4.1	-1.6	-1.5	-2.0	-0.7
Diabetes (self-reported)	0.5	0.8	2.1	-0.7	-1.4	0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.4	0.1	1.1	0.7	1.2
Medication: Ramipril	0.8	1.1	1.9	0.3	-0.9	1.4	-1.3
Medication: Simvastatin	1.1	1.6	4.8	-0.8	-2.2	-0.2	-1.0
Fluid intelligence score	0.4	0.8	2.5	-0.2	1.6	-0.6	0.5
Illnesses of siblings	0.7	0.9	1.2	0.9	1.0	0.8	1.1
Neuroticism score	1.0	2.0	4.7	-2.2	-0.8	-1.5	-0.7
Weight	0.6	3.1	6.5	-2.6	-1.2	-1.2	-1.7
Impedance of arm (right)	2.0	9.1	15.9	3.8	1.1	2.1	4.0
Arm fat percentage (right)	1.5	5.8	10.5	-3.2	-2.1	-2.0	-2.1
Trunk fat-free mass	0.2	1.1	2.9	-0.9	0.6	-0.3	-1.7
Hip circumference	1.1	4.6	7.5	-2.7	-1.8	-1.3	-2.4
Time employed in main current job	1.0	1.2	3.6	0.7	-1.9	0.7	0.1
Alcohol intake versus 10 years previously	0.6	0.9	2.2	-0.5	-1.0	0.0	1.5
Father’s age at death	0.2	0.2	0.5	0.6	0.2	0.2	0.7
Worrier / anxious feelings	0.9	1.6	5.9	-0.3	-2.4	-0.7	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.8	-0.6	-2.2	-1.0	0.7
Falls in the last year	0.1	0.1	0.4	0.1	0.1	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	-0.2	-0.6	-1.0	0.0
Number of live births	0.5	0.7	1.8	-0.6	-0.3	-1.3	0.8
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	16.3	3.6	0.3	2.4	4.0
Pulse rate	0.9	1.5	3.4	-1.9	-0.7	-0.3	-1.3
Happiness	0.5	0.6	1.2	-0.7	-1.1	0.0	0.8
Noisy workplace	0.8	0.9	3.6	0.1	-1.9	-0.3	0.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.9	2.2	1.8	0.5	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.2	0.6	0.4	0.2	1.1
Mouth/teeth dental problems: Dentures	1.2	2.0	6.6	-0.5	-2.6	-0.8	-0.7
Asthma	1.1	2.1	4.8	-1.7	-0.7	-0.1	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.2	-1.2	-1.5	-0.3	-0.7
Medication: Cholesterol lowering	0.2	0.4	0.9	-1.0	-0.5	-0.5	-0.2
Depression (self-reported)	0.2	0.2	0.5	0.4	-0.7	0.1	0.3
Medication: Lansoprazole	0.7	0.8	1.9	-1.4	-1.0	-0.5	-0.2
Prospective memory result	0.8	1.0	1.5	-1.1	-0.6	-0.8	1.2
Lung cancer (father)	0.6	0.7	1.4	-0.4	0.9	0.5	-1.2
Illnesses of mother	0.7	0.9	2.5	-0.7	1.6	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	11.5	2.8	0.5	1.4	3.4
Pulse wave Arterial Stiffness index	1.1	1.3	3.0	-0.2	-1.1	-1.1	-1.7
Impedance of arm (left)	2.5	11.7	22.0	4.3	0.9	2.3	4.7
Arm fat mass (right)	1.5	6.2	11.2	-3.3	-2.0	-2.0	-2.3
Trunk predicted mass	0.2	1.0	2.7	-1.0	0.6	-0.4	-1.6
Standing height	0.8	7.9	13.5	3.7	1.8	2.1	3.2
Length of working week for main job	0.5	0.5	0.9	0.3	-0.8	0.7	0.9
Exposure to tobacco smoke at home	2.1	2.4	5.2	-2.0	-0.5	-0.4	-2.3
Breastfed as a baby	1.7	2.1	3.3	-1.7	0.3	-1.8	-1.4
Tense / ‘highly strung’	1.3	2.1	6.3	-2.5	0.2	-1.0	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	5.0	-0.5	-1.9	-2.2	0.0
Hair/balding pattern: Pattern 4	0.4	1.0	3.1	-0.8	-0.0	-0.2	-1.8
Birth weight of first child	1.3	2.3	4.2	1.1	0.8	1.8	2.0
Peak expiratory flow (PEF)	1.7	3.9	7.7	2.8	-0.0	1.5	2.4
Pulse wave reflection index	0.5	0.6	2.0	0.4	-0.1	-0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	0.5	0.1	0.6	1.2
Loud music exposure frequency	0.9	1.0	2.6	-0.8	-0.7	1.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	1.8	0.9	-0.4	1.0
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	12.7	0.7	1.4	3.6	1.4
Blood clot in the leg (DVT)	2.1	2.7	6.1	-0.2	-2.5	-1.9	-0.9
Medication: Paracetamol	0.3	0.4	0.9	-0.9	-0.9	-0.1	-0.3
Headache pain in last month	0.5	0.9	2.5	-1.6	0.2	0.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	0.4	1.1	-0.0	0.0
Glaucoma (self-reported)	0.4	0.5	1.3	0.4	-1.1	0.5	-0.5
Gout (self-reported)	1.0	1.4	2.9	1.0	-1.0	1.7	0.9
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.9	-1.4	-1.3	0.0	-0.3
Medication: Amlodipine	1.5	2.1	4.0	-2.0	-0.4	-1.3	-1.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.1	0.4	0.6	1.0	1.1
Birth weight	0.4	0.9	3.0	0.1	-1.7	0.8	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	0.1	-0.1	-1.2	-0.6
High blood pressure (siblings)	0.5	0.7	1.1	-0.7	-1.1	-0.6	-1.0
Forced vital capacity (FVC), Best measure	1.3	4.7	9.9	2.9	0.2	0.8	3.1
Body fat percentage	1.2	4.8	7.9	-2.8	-2.5	-1.9	-1.2
Leg fat percentage (right)	2.5	9.0	15.1	-3.9	-3.0	-2.8	-2.0
Arm fat-free mass (right)	0.2	1.1	2.2	-1.4	-0.2	0.0	-1.5
Exposure to tobacco smoke outside home	0.5	0.6	2.2	-1.5	-0.2	0.0	-0.6
Comparative body size at age 10	0.5	1.4	3.4	0.6	-1.8	-1.3	-0.3
Number of full brothers	0.8	1.0	1.8	0.0	-1.3	-1.3	0.6
Worry too long after embarrassment	2.2	3.7	7.1	-2.6	-0.1	-2.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-1.0	0.2	-0.5	-0.9
Wheeze or whistling in the chest in last year	1.9	3.5	5.0	-1.9	-1.1	-2.2	-2.0
Number of children fathered	0.9	1.0	2.0	1.4	-0.5	0.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.2	-0.0	-0.4	0.0
Age at first live birth	2.3	4.1	9.4	3.1	1.7	1.3	1.5
Pulse wave peak to peak time	1.9	2.3	5.9	0.8	0.9	1.3	2.4
Health satisfaction	2.0	2.6	6.0	-1.8	-1.1	-2.4	0.1
Shortness of breath walking on level ground	1.7	2.0	4.8	-1.4	-0.6	-0.9	-2.2
Qualifications: College or University degree	1.1	3.6	11.1	1.7	3.3	0.4	0.3
Eye problems/disorders: None of the above	1.6	1.9	4.8	-1.5	-0.1	-2.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.4	-0.9	-0.4	-0.2
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.5	1.0	0.5	-0.1
Medication for pain relief, constipation, heartburn	1.4	2.4	3.5	1.9	1.2	1.4	1.6
Neck or shoulder pain in last month	0.5	0.6	1.8	-0.5	-1.4	0.4	0.6
Medication: Blood pressure	0.6	1.1	4.2	0.3	-2.1	0.0	0.1
Angina (self-reported)	0.9	1.2	3.2	-0.0	-1.8	-0.2	-1.3
Migraine (self-reported)	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2
Medication: Ibuprofen	0.3	0.3	0.8	-0.3	-0.5	-0.4	-0.9
Medication: Allopurinol	1.8	2.4	4.7	1.2	-0.9	2.2	1.7
Medication: Omeprazole	0.2	0.3	0.8	-0.9	0.0	-0.0	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.6	-0.3	0.9	-0.0
Mean time to correctly identify matches	0.8	1.5	3.4	1.9	1.3	-0.9	0.2
Heart disease (mother)	0.6	0.8	2.4	-0.1	-1.6	-0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.8	-0.3	-0.1	0.3
Whole body fat mass	1.1	4.5	8.3	-2.9	-2.0	-1.7	-1.6
Leg fat mass (right)	1.6	6.2	11.0	-3.3	-2.3	-2.1	-2.0
Arm predicted mass (right)	0.2	1.2	2.5	-1.4	-0.5	-0.3	-1.6
Pulse rate, automated reading	2.0	6.4	16.4	-4.0	-0.9	-1.6	-2.5
Alcohol intake frequency.	0.5	1.3	2.7	-1.6	-1.2	0.7	-0.7
Comparative height size at age 10	0.5	2.7	6.5	2.5	0.1	0.6	2.0
Number of full sisters	0.5	0.6	1.0	-1.0	-0.0	-0.8	0.7
Suffer from ‘nerves’	1.3	2.0	4.7	-0.9	-2.2	-1.4	-0.8
Overall health rating	2.5	5.3	12.0	-3.5	-1.3	-1.4	-2.4
Chest pain or discomfort	1.1	1.6	3.7	-1.6	-0.2	-0.4	-1.9
Had major operations	0.6	0.7	1.6	-1.3	-1.1	0.2	0.1
Age at last live birth	2.5	3.7	8.7	2.9	1.2	1.9	1.0
Family relationship satisfaction	0.5	0.6	2.0	-0.4	-0.1	-0.3	1.4
Leg pain on walking	1.1	1.4	3.6	0.5	-1.9	-1.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	0.7	-1.7	-0.2	0.9
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.4	-0.3	-2.3	-1.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.3	1.5	-0.8	0.2	0.6
Medication: Aspirin	0.3	0.4	0.7	-0.8	0.3	-0.3	-0.7
Supplements: Vitamin C	0.9	1.1	3.5	-0.3	-0.3	-0.8	-1.9
Knee pain experienced in last month	0.1	0.2	0.3	-0.4	0.3	0.5	0.6
Hypertension (Self-reported)	1.0	2.7	7.5	1.8	-2.7	0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	0.5	-0.7	-0.5	0.9
Illnesses of father: Heart disease	0.3	0.4	0.6	0.5	0.6	0.8	0.7
Illnesses of siblings: Diabetes	1.8	2.3	7.7	-2.8	-0.1	-0.1	-1.2
Smoking status: Previous	2.2	3.3	7.9	2.8	-1.5	0.8	1.5
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.3	9.2	2.9	2.6	2.2	3.0
Whole body fat-free mass	0.2	1.0	2.4	-1.2	0.4	-0.0	-1.5
Leg fat-free mass (right)	0.1	0.6	1.2	-1.1	0.3	0.4	-1.1
Arm fat percentage (left)	1.1	4.5	8.0	-2.8	-2.2	-1.7	-1.5
Average weekly red wine intake	1.6	2.4	5.0	1.7	2.2	-0.6	1.1
Handedness (chirality/laterality): Left-handed	2.0	2.4	6.5	0.7	0.8	2.5	1.4
Mood swings	0.7	1.4	4.6	-0.8	-2.1	-0.3	-0.4
Loneliness, isolation	0.6	0.8	1.7	-1.3	0.7	-0.3	-1.1
Long-standing illness, disability or infirmity	1.1	1.6	4.4	-2.1	-1.3	-0.6	0.0
Ever had bowel cancer screening	0.1	0.2	0.4	0.6	0.0	-0.2	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.1	-1.0	-1.0	0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.3	0.3	-0.5	0.1	1.8
Friendships satisfaction	1.0	1.3	3.3	-0.6	1.8	0.6	1.1
Qualifications: nursing, teaching	1.1	1.6	3.2	0.8	0.1	1.8	1.7
Commuting to job workplace: Walk	3.6	3.9	6.7	1.4	2.4	1.2	2.6
Eye problems/disorders: Cataract	0.4	0.4	1.2	1.1	0.1	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.9	1.7	0.5	0.4	2.0
Medication for cholesterol	0.5	0.7	1.7	0.0	1.3	0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	0.5	-0.8	0.6	0.2
Back pain experienced in last month	0.2	0.2	0.5	-0.7	-0.2	0.2	-0.6
Mineral and other dietary supplements	2.6	3.5	10.0	1.7	0.5	0.9	3.2
Breast cancer (self-reported)	1.3	1.5	3.0	0.9	1.4	0.4	1.7
Asthma (self-reported)	0.8	1.5	3.5	-1.5	-0.6	-0.0	-1.9
Osteoporosis (self-reported)	3.9	4.9	10.2	2.0	0.2	2.3	3.2
Osteoarthritis (self-reported)	0.8	1.0	2.7	-1.6	0.2	-1.2	0.0
Medication: Aspirin	0.5	0.6	1.2	-1.1	0.2	-0.5	-1.0
Medication: Gliclazide	0.3	0.3	0.8	-0.3	-0.4	-0.3	0.9
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.8	0.2	0.1	-0.6
Smoking status: Current	4.4	7.0	14.1	-3.8	-0.4	-2.2	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.6	2.1	1.6	0.9	1.2
Whole body water mass	0.2	1.0	2.3	-1.2	0.3	0.0	-1.5
Leg predicted mass (right)	0.1	0.7	1.3	-1.1	0.3	0.5	-1.1
Arm fat mass (left)	1.5	6.0	10.3	-3.2	-2.0	-2.0	-2.3
Number of self-reported non-cancer illnesses	1.4	2.4	4.2	-1.3	-1.9	-2.0	-0.4
Average weekly champagne plus white wine intake	2.7	3.7	6.2	1.8	2.5	2.3	0.1
Miserableness	0.7	1.3	2.5	-0.4	-1.6	-0.9	-1.2
Guilty feelings	0.5	0.7	2.6	-0.4	-0.1	-1.6	-0.3
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	-0.2	-0.7	-0.7
Ever taken oral contraceptive pill	3.5	3.9	6.0	2.4	1.9	1.0	2.2
Hearing aid user	0.4	0.5	1.2	-0.2	1.1	0.2	0.7
Mother’s age at death	1.2	1.5	4.7	1.0	-0.0	-2.2	-0.7
Financial situation satisfaction	0.7	0.9	2.2	-1.5	0.3	-1.1	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.0	-1.4	0.3	0.0	-1.1
Commuting to job workplace: Public transport	1.9	2.2	7.4	0.3	2.7	1.1	0.5
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	1.0	-0.3	0.8	-0.2
Medication: Blood pressure	0.6	1.1	2.1	1.1	-1.4	0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.0	-0.1	-1.4	-0.8	0.3
Supplements: Fish oil (including cod liver oil)	2.8	3.6	9.5	-1.0	-0.8	-1.9	-3.1
High cholesterol (Self-reported)	0.9	1.5	5.9	-0.0	-2.4	-0.4	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.4	-0.4	-0.7	1.2	-1.0
Medication: Paracetamol	0.5	0.8	1.0	-1.0	-0.6	-1.0	-1.0
Medication: Lisinopril	3.6	4.7	11.3	-1.6	-1.5	-3.4	-1.6
Medication: Atorvastatin	0.1	0.1	0.3	-0.5	-0.1	0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.3	-0.3	0.4	-0.3
Alcohol drinker status: Never	0.4	0.4	0.9	-1.0	0.5	0.4	-0.7
Ever smoked	0.6	1.0	2.1	1.2	-1.4	-0.6	-0.3
Basal metabolic rate	0.3	1.4	2.9	-1.7	-0.1	-0.4	-1.6
Leg fat percentage (left)	2.3	8.2	13.9	-3.7	-2.8	-2.2	-2.5
Arm fat-free mass (left)	0.6	3.1	6.5	-2.3	-0.4	-0.7	-2.6
Number of operations (self-reported)	1.2	1.8	4.6	-2.1	1.5	-0.4	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.5	-0.4	0.1	-0.5
Irritability	0.2	0.3	1.0	-0.5	0.0	-1.0	-0.4
Risk taking	1.1	1.7	2.7	-1.5	1.0	0.9	-1.6
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.3	-2.1	0.3	-0.9	-1.4
Fractured/broken bones in last 5 years	0.9	1.2	2.7	0.9	-1.6	0.8	0.7
Age started oral contraceptive pill	0.2	0.2	0.6	0.8	-0.1	0.6	-0.0
Diastolic blood pressure, automated reading	1.5	4.5	7.1	-1.0	-2.0	-2.5	-2.7
Ever depressed for a whole week	1.2	1.4	3.0	-0.8	-1.7	-1.3	-0.5
Unable to work because of sickness or disability	2.8	3.7	9.9	-1.0	-3.1	-1.9	-0.4
Commuting to job workplace: Cycle	1.7	2.0	3.3	0.9	1.7	0.9	1.8
Myopia	0.2	0.3	0.7	0.6	0.2	0.4	0.9
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.1	-1.7	2.3	-0.1	-0.0
Cholesterol lowering medication	1.0	1.5	3.8	-0.7	-2.0	-0.4	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.7	-0.3	-0.0	-0.5
Pain experienced in last month	0.7	1.2	4.1	2.0	0.3	0.8	-0.2
Supplements: Calcium	0.8	0.9	2.3	0.0	1.5	0.2	-1.1
Basal cell carcinoma (self-reported)	2.3	2.7	6.6	2.6	0.8	1.0	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	-0.1	-0.5	0.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	7.6	-0.3	-2.8	-2.1	-0.9
Heart disease (siblings)	0.4	0.4	1.2	-0.5	0.3	-1.1	-0.5
Alcohol drinker status: Previous	1.2	1.4	3.9	0.5	-0.5	2.0	1.2
Pack years of smoking	4.0	5.9	14.6	-3.8	-0.4	-1.8	-2.4
Impedance of whole body	1.6	8.3	16.0	3.7	0.3	1.8	4.0
Leg fat mass (left)	1.5	6.0	10.7	-3.3	-2.2	-1.7	-2.4
Arm predicted mass (left)	0.4	2.1	4.1	-2.0	-0.5	-0.5	-2.0