TWAS hub - SAMHD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0377	0.0129	4.2e-06	0.001	0.017	0.013	0.017	0.004	0.2000	2.6e-06	3.6e-05	2.9e-06	0.01400
2	ROSMAP	Brain Pre-frontal Cortex	0.0466	0.0186	3.8e-04	0.017	0.029	0.014	0.030	0.026	0.0023	1.2e-04	5.1e-03	7.3e-05	0.00025

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Tanning	9.5	115.6	231.0	15.2	0.3
Financial situation satisfaction	9.2	11.4	13.0	-3.1	-3.6
Prospective memory result	7.2	8.9	12.4	-2.3	-3.5
Alcohol intake frequency.	7.2	16.8	28.3	-2.3	-5.3
Comparative height size at age 10	6.7	36.9	60.1	-3.7	-7.8
Qualifications: O levels/GCSEs or equivalent	6.5	10.4	11.3	3.1	3.4
Pain experienced in last month	6.2	10.3	19.3	1.1	4.4
Back pain experienced in last month	6.1	8.9	14.1	-1.9	-3.8
Qualifications: NVQ or HND or HNC or equivalent	5.5	6.6	7.4	-2.4	-2.7
Bilateral oophorectomy (both ovaries removed)	4.9	5.6	6.6	-2.6	-2.1
Glaucoma (self-reported)	4.9	5.7	8.7	2.9	1.7
Alcohol drinker status: Previous	4.9	5.5	10.3	-0.9	-3.2
Exposure to tobacco smoke outside home	4.8	6.4	10.3	-1.6	-3.2
Smoking status: Previous	4.8	7.2	10.6	-3.3	-1.9
Height	4.6	88.9	146.4	-5.6	-12.1
Overall health rating	4.1	8.7	13.8	-1.9	-3.7
Alcohol intake versus 10 years previously	4.0	5.9	11.0	-0.9	-3.3
Stomach or abdominal pain in last month	3.9	4.9	5.9	-2.0	-2.4
Hair Pigment	3.8	109.5	205.5	-14.3	3.7
HbA1C	3.7	4.1	6.2	-2.5	-1.4
Frequency of depressed mood in last 2 weeks	3.7	5.2	6.3	-2.5	-2.0
Qualifications: A levels/AS levels or equivalent	3.7	8.1	8.3	2.8	2.9
Primary Biliary Cirrhosis	3.6	5.1	5.6	-2.1	-2.4
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.8	9.6	-1.4	-3.1
Verbal and Numeric Reasoning (VNR)	3.4	8.2	10.5	3.2	2.5
Intelligence (Savage-Jansen 2018)	3.2	10.0	14.0	3.7	2.4
Ovarian Cancer	3.2	4.2	8.2	2.9	0.4
Trunk fat-free mass	3.2	18.3	36.5	-0.2	-6.0
Ever taken oral contraceptive pill	3.2	3.6	5.7	1.2	2.4
Trunk predicted mass	3.1	17.7	35.3	-0.1	-5.9
Average weekly red wine intake	3.1	4.5	8.3	0.9	2.9
Fasting Glucose	3.0	3.6	4.1	1.7	2.0
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	4.8	-1.3	-2.2
Whole body water mass	3.0	17.0	33.9	-0.4	-5.8
Average weekly champagne plus white wine intake	3.0	4.1	4.7	2.2	1.9
Maternal smoking around birth	2.9	4.1	4.6	-1.9	-2.1
Financial difficulties in last 2 years	2.9	3.9	7.0	-1.0	-2.6
Fluid intelligence score	2.9	6.1	8.2	2.9	2.0
Whole body fat-free mass	2.9	16.3	32.5	-0.4	-5.7
Standing height	2.8	28.2	52.5	-1.9	-7.2
Health satisfaction	2.8	3.6	5.1	-1.5	-2.2
Shortness of breath walking on level ground	2.8	3.3	5.1	2.3	1.2
Basal metabolic rate	2.8	15.8	31.2	-0.5	-5.6
Mouth/teeth dental problems: Dentures	2.7	4.5	5.2	-1.9	-2.3
Arm fat-free mass (right)	2.7	13.7	27.4	0.4	-5.2
Arm predicted mass (right)	2.7	13.6	27.2	0.3	-5.2
Knee pain experienced in last month	2.7	4.2	7.4	-1.0	-2.7
Commuting to job workplace: Walk	2.7	3.0	5.8	0.4	2.4
Arm fat-free mass (left)	2.7	13.8	27.6	-0.1	-5.3
Arm predicted mass (left)	2.7	13.8	27.7	-0.1	-5.3
Medication: Metformin	2.6	3.6	7.1	-0.4	-2.7
Relative age voice broke	2.6	4.0	8.0	0.3	2.8
Qualifications: CSEs or equivalent	2.6	3.5	4.8	-1.5	-2.2
Illnesses of father: Heart disease	2.6	3.6	6.8	2.6	0.7
Leg predicted mass (right)	2.6	14.1	27.7	-0.8	-5.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	5.0	1.0	2.2
Fed-up feelings	2.5	4.5	5.9	-1.8	-2.4
Past tobacco smoking	2.5	4.5	7.6	2.8	1.2
Chest pain or discomfort	2.5	3.5	5.8	-1.1	-2.4
Leg fat-free mass (right)	2.5	13.5	26.7	-0.6	-5.2
Leg fat-free mass (left)	2.4	12.6	24.9	-0.6	-5.0
Leg predicted mass (left)	2.4	12.6	24.8	-0.6	-5.0
Medication: Paracetamol	2.4	4.0	6.5	-1.2	-2.5
Medication: Atenolol	2.3	2.9	5.8	0.1	-2.4
Weight	2.2	11.0	21.2	-0.9	-4.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	4.8	-0.9	-2.2
Alzheimer’s Disease (in mother)	2.0	2.3	3.0	-1.7	-1.3
Long-standing illness, disability or infirmity	2.0	3.1	3.3	-1.8	-1.7
Medication: Paracetamol	2.0	3.2	4.5	-1.4	-2.1
Father’s age at death	1.9	2.6	2.6	1.6	1.6
Supplements: Vitamin C	1.9	2.3	4.4	2.1	-0.3
Mood swings	1.9	3.5	5.3	-2.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.5	-1.0	-1.9
Medication: Gliclazide	1.9	2.1	3.5	-0.8	-1.9
Medication: Bendroflumethiazide	1.9	2.9	3.7	-1.9	-1.4
Relative age of first facial hair	1.8	3.7	4.6	1.7	2.1
Allergy	1.8	4.1	6.7	-2.6	-1.2
Exposure to tobacco smoke at home	1.8	2.0	2.5	-1.6	-1.2
Emphysema/chronic bronchitis	1.8	2.0	2.1	1.4	1.4
Breast cancer (self-reported)	1.8	2.1	3.8	1.9	0.7
High cholesterol (Self-reported)	1.8	3.1	4.3	-1.4	-2.1
Mean Putamen Volume	1.7	1.9	3.9	2.0	0.1
Lupus	1.7	2.5	5.1	-0.0	2.3
Townsend deprivation index at recruitment	1.7	2.4	3.4	-1.9	-1.2
Sitting height	1.7	11.8	23.6	-0.2	-4.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.3	1.8	1.1
Illnesses of mother	1.7	2.1	2.7	1.2	1.6
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.9	-2.0	-0.5
Pain all over the body in last month	1.6	1.7	3.3	-1.8	-0.3
Falls in the last year	1.6	2.2	4.3	-0.2	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.1	0.8	1.8
Neck or shoulder pain in last month	1.6	2.3	4.2	-0.6	-2.1
Medication: Aspirin	1.6	2.1	3.5	1.9	0.8
Type 2 Diabetes (T2D) (2018)	1.5	2.7	3.0	1.6	-1.7
Number of treatments/medications taken	1.5	2.6	5.1	-0.4	-2.3
Waist circumference	1.5	5.3	9.1	-1.3	-3.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	8.5	-1.2	-2.9
Depression (self-reported)	1.5	1.8	3.0	-0.8	-1.7
Had major operations	1.5	1.8	2.2	1.5	1.2
Friendships satisfaction	1.5	1.9	2.7	-1.1	-1.6
Smoking Status	1.4	3.2	4.7	-1.3	-2.2
Hearing difficulty/problems with background noise	1.4	2.2	4.3	-2.1	-0.4
Illnesses of siblings	1.4	2.0	2.3	-1.5	1.3
Happiness	1.4	1.7	2.2	-1.1	-1.5
Pulse wave reflection index	1.4	1.8	2.6	-1.6	-1.0
Alcohol drinker status: Never	1.4	1.7	2.5	-1.0	-1.6
Depressed Affect (Nagel 2018)	1.3	2.6	3.3	-1.8	-1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.2	-1.5	-1.1
Pack years adult smoking proportion	1.3	2.0	2.9	1.1	-1.7
Trunk fat mass	1.3	5.7	8.4	-1.7	-2.9
Leg pain on walking	1.3	1.6	3.0	-0.4	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.4	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	5.6	0.1	-2.4
Diabetes diagnosed by doctor	1.3	2.1	2.9	1.1	-1.7
Arm fat mass (left)	1.3	5.2	8.1	-1.5	-2.8
Risk taking	1.3	1.9	3.6	-0.5	-1.9
Bipolar Disorder (2018)	1.2	1.9	3.6	1.9	-0.6
Crohns Disease (2012)	1.2	1.9	2.7	-1.6	-1.1
Forced vital capacity (FVC)	1.2	4.6	7.9	-1.1	-2.8
Diabetes (self-reported)	1.2	1.9	2.6	1.6	-1.1
High blood pressure (siblings)	1.2	1.8	3.6	1.9	-0.0
Whole body fat mass	1.2	5.2	8.7	-1.3	-2.9
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.7	1.1	-1.3
Illnesses of siblings: Diabetes	1.2	1.5	3.0	1.7	-0.2
Medication for cholesterol	1.2	1.8	2.1	1.4	1.2
Ever smoked	1.2	2.2	3.5	-1.9	-0.9
Basal cell carcinoma (self-reported)	1.2	1.4	1.6	-1.3	-1.1
HDL Cholesterol	1.1	1.9	3.2	-1.8	-0.8
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.0	2.0	1.0
Mouth/teeth dental problems	1.1	1.7	3.3	0.3	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-0.0	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.4	-1.2	-2.3
Peak expiratory flow (PEF)	1.1	2.5	5.1	-0.1	-2.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.8	-0.2	-1.7
Medication for pain relief, constipation, heartburn	1.1	1.8	3.6	-0.3	1.9
Miserableness	1.1	2.0	2.1	-1.4	-1.5
Age started oral contraceptive pill	1.1	1.3	2.0	-0.8	1.4
Heart disease (siblings)	1.1	1.4	2.4	1.6	-0.6
Pack years of smoking	1.1	1.6	2.2	1.0	-1.5
Heart attack	1.0	1.3	2.5	1.6	0.1
Hair/balding pattern: Pattern 3	1.0	1.6	2.0	-1.4	-1.1
Pulse wave Arterial Stiffness index	1.0	1.2	1.4	-1.0	-1.2
Arm fat mass (right)	1.0	4.3	7.0	-1.2	-2.7
Medication: Blood pressure	1.0	1.7	3.4	0.1	-1.8
Medication: Omeprazole	1.0	1.2	2.1	0.5	-1.4
Family relationship satisfaction	1.0	1.3	2.0	-0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.2	-0.1	-1.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.7	1.6	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.5	1.6	0.1
Bipolar Disorder or Schizophrenia	0.9	2.2	3.7	1.9	-0.9
Blood Eosinophil Count	0.9	7.2	14.3	-0.2	-3.8
Diabetes (mother)	0.9	1.1	2.1	-0.4	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.8	2.0	-0.4
Chronic bronchitis/emphysema (father)	0.9	1.1	1.6	-1.3	-0.7
Impedance of arm (right)	0.9	4.2	6.2	-2.5	1.5
Hip circumference	0.9	4.0	8.1	-0.1	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.6	0.2	-1.6
Qualifications: nursing, teaching	0.9	1.4	1.4	1.2	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.5	0.9	-1.2
Depression (Nagel 2018)	0.8	1.2	1.7	-1.3	-0.8
Prostate Cancer	0.8	1.2	1.2	-1.1	1.1
Allergy or Eczema	0.8	2.0	3.6	1.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.8	-0.9	-1.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	0.3	1.4
Asthma	0.8	1.6	2.2	1.1	1.5
Impedance of arm (left)	0.8	3.8	6.6	-2.6	1.0
Breastfed as a baby	0.8	1.0	1.3	-1.2	0.9
Qualifications: College or University degree	0.8	2.6	3.1	1.4	1.8
Medication: Aspirin	0.8	1.0	1.9	1.4	0.3
Ever had bowel cancer screening	0.8	0.9	1.0	-0.9	1.0
Supplements: Calcium	0.8	0.9	1.3	-0.7	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.6	1.3	-0.7
Leg fat mass (left)	0.8	3.0	5.8	-0.5	-2.4
Schizophrenia vs Biploar Disorder	0.7	0.9	1.0	-1.0	-0.9
Rheumatoid Arthritis	0.7	1.0	2.0	-0.1	1.4
Blood Red Count	0.7	6.8	7.6	-2.8	-2.4
Hand grip strength (left)	0.7	1.7	3.5	-0.1	-1.9
Trunk fat percentage	0.7	3.0	3.7	-1.9	-1.5
Taking other prescription medications	0.7	1.0	2.0	-0.4	-1.4
Alcohol usually taken with meals	0.7	1.1	1.6	0.8	1.3
Had other major operations	0.7	0.8	1.4	-0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	-0.2	-1.3
Blood clot in the leg (DVT)	0.7	1.0	1.7	1.3	-0.5
Medication: Amlodipine	0.7	1.0	1.9	1.4	0.2
Medication: Ibuprofen	0.7	0.9	1.8	-0.1	-1.3
Leg fat mass (right)	0.7	2.7	5.3	-0.4	-2.3
Number of full sisters	0.7	0.8	1.0	-1.0	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	-0.4	1.2
Asthma (self-reported)	0.7	1.3	1.8	0.9	1.3
Mother’s age at death	0.7	0.9	1.2	1.1	0.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.6	1.3	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	1.8	-0.1	1.3
Ever depressed for a whole week	0.7	0.9	1.0	-0.9	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.2	0.8	1.8
Alzheimer’s Disease (in father)	0.6	0.7	1.0	-0.6	1.0
Breast Cancer	0.6	1.4	2.0	0.9	-1.4
BMI	0.6	3.4	4.7	1.4	-2.2
Chronotype (morning person)	0.6	1.4	2.0	-1.4	0.8
Sensitivity / hurt feelings	0.6	1.1	2.2	-1.5	0.0
Diabetes (father)	0.6	0.7	1.4	1.2	0.3
Age when periods started (menarche)	0.6	1.4	2.0	0.9	1.4
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-0.3	-1.2
High blood pressure	0.6	1.6	1.6	-1.2	-1.3
Time employed in main current job	0.6	0.7	1.2	1.1	0.5
Forced vital capacity (FVC), Best measure	0.6	2.2	3.8	-0.8	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.3	0.5	-1.1
Pulse wave peak to peak time	0.6	0.7	0.8	0.9	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.2	-1.1	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	-1.2	-0.3
Osteoporosis (self-reported)	0.6	0.7	1.4	0.3	1.2
Impedance of whole body	0.6	3.1	3.9	-2.0	1.5
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	-1.0	0.3
Supplements: Zinc	0.5	0.5	1.0	1.0	-0.3
Medication: Levothyroxine sodium	0.5	0.8	1.6	0.1	-1.3
Had menopause	0.5	0.6	1.0	1.0	0.5
Worrier / anxious feelings	0.5	1.0	1.9	0.3	1.4
Headache pain in last month	0.5	0.8	1.6	0.3	-1.3
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.8	0.9	-0.5
Medication: Atorvastatin	0.5	0.6	1.0	1.0	0.4
Unable to work because of sickness or disability	0.5	0.6	0.8	-0.9	-0.7
Myopia	0.5	0.8	1.0	0.7	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	0.9	0.7	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	-1.1	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.9	-0.0
Lung FVC	0.4	2.0	3.2	-1.8	-0.9
Medication: Co-codamol	0.4	0.5	0.6	-0.6	-0.8
Impedance of leg (right)	0.4	1.9	3.5	-0.6	1.9
Supplements: Glucosamine	0.4	0.5	0.8	0.9	-0.4
High blood pressure (mother)	0.4	0.5	1.1	0.0	-1.0
Qualifications: None of the above	0.4	0.9	1.6	-1.3	-0.5
Medication: Ramipril	0.4	0.5	0.9	0.4	-0.9
Medication: Simvastatin	0.4	0.6	1.1	-0.3	-1.1
Arm fat percentage (right)	0.4	1.7	2.6	-1.6	-0.9
Noisy workplace	0.4	0.5	0.7	-0.6	-0.8
Medication: Lansoprazole	0.4	0.5	0.7	-0.5	-0.8
Length of working week for main job	0.4	0.4	0.6	0.8	0.5
Body fat percentage	0.4	1.7	2.1	-1.4	-1.1
Worry too long after embarrassment	0.4	0.7	1.1	-1.0	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.0	0.7	-1.0
Heart disease (mother)	0.4	0.5	0.9	-0.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.9	-0.5
Pulse rate, automated reading	0.4	1.3	2.0	1.4	0.8
Hypertension (Self-reported)	0.4	1.0	1.2	-0.9	-1.1
Arm fat percentage (left)	0.4	1.8	2.4	-1.5	-1.1
Mineral and other dietary supplements	0.4	0.6	0.8	-0.9	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.4	0.7	-0.9	-0.4
Guilty feelings	0.4	0.6	1.0	-1.0	-0.4
Wears glasses or contact lenses	0.4	0.4	0.6	-0.8	-0.5
Number of operations (self-reported)	0.4	0.6	1.1	-0.3	-1.0
Irritability	0.4	0.7	0.9	-0.7	1.0
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.1	0.9
Neuroticism (Nagel 2018)	0.3	0.8	1.5	-1.2	-0.2
Schizophrenia (2018)	0.3	0.7	0.9	1.0	-0.7
Major Depression (MDD)	0.3	0.3	0.6	-0.8	-0.1
Schizophrenia (2014)	0.3	0.6	0.9	0.5	-1.0
Blood Platelet Count	0.3	3.0	5.2	-2.3	0.9
Heel T-Score	0.3	2.3	4.0	0.8	2.0
Waist Hip Ratio (WHR)	0.3	1.2	2.2	-1.5	-0.5
Lung FEV1/FVC ratio	0.3	1.5	1.6	1.2	-1.3
Neuroticism	0.3	0.8	1.2	-1.1	-0.6
Severe depression (siblings)	0.3	0.3	0.6	0.3	0.8
Hand grip strength (right)	0.3	0.7	1.5	-0.0	-1.2
Body mass index (BMI)	0.3	1.4	2.7	-0.3	-1.6
Impedance of leg (left)	0.3	1.4	2.2	-0.8	1.5
Neuroticism score	0.3	0.7	1.4	-1.2	0.0
Number of live births	0.3	0.5	0.5	-0.7	-0.7
Medication: Cholesterol lowering	0.3	0.5	0.7	0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-0.3	-1.0
Number of full brothers	0.3	0.4	0.8	-0.1	-0.9
Age at first live birth	0.3	0.6	0.6	0.8	0.7
Angina (self-reported)	0.3	0.4	0.6	0.8	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.1	-0.3	-1.0
Cholesterol lowering medication	0.3	0.4	0.8	0.2	-0.9
Worry (Nagel 2018)	0.2	0.3	0.6	0.3	0.8
Crohns Disease (2017)	0.2	0.4	0.5	-0.7	-0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.5	0.3
LDL Cholesterol	0.2	0.3	0.6	0.2	0.8
Ulcerative Colitis	0.2	0.3	0.4	-0.3	-0.7
Cardiovascular Disease	0.2	0.7	1.4	0.0	-1.2
Respiratory disease	0.2	0.4	0.8	0.2	0.9
Average weekly spirits intake	0.2	0.3	0.5	-0.7	-0.4
Angina	0.2	0.3	0.3	0.6	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.6	-0.1
Current tobacco smoking	0.2	0.4	0.6	0.5	-0.7
Average weekly fortified wine intake	0.2	0.2	0.3	0.2	-0.6
Multivitamins +/- minerals	0.2	0.2	0.4	0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.2	-0.5	0.5
Nervous feelings	0.2	0.4	0.6	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.1	1.1	0.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.0	-0.6
Number of children fathered	0.2	0.2	0.4	-0.1	-0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.1	-0.6
Age at last live birth	0.2	0.3	0.5	-0.0	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.8	-0.0
Osteoarthritis (self-reported)	0.2	0.3	0.3	0.5	-0.5
Smoking status: Current	0.2	0.3	0.6	0.2	-0.8
Medication: Lisinopril	0.2	0.2	0.3	0.4	-0.5
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.3	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.7	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.3	0.5
Reaction Time	0.1	0.2	0.3	0.5	-0.4
Age at First Birth	0.1	0.1	0.1	-0.2	0.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.1	-0.6
Blood White Count	0.1	0.5	0.9	-0.2	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.3	-0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.7	0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	0.4
Number of incorrect matches in round	0.1	0.1	0.3	0.5	-0.1
Pulse rate	0.1	0.1	0.2	0.5	-0.1
Tense / ‘highly strung’	0.1	0.2	0.3	-0.1	0.6
Loud music exposure frequency	0.1	0.1	0.1	-0.3	-0.2
Gout (self-reported)	0.1	0.2	0.3	-0.6	-0.3
Migraine (self-reported)	0.1	0.1	0.1	0.4	-0.0
Medication: Allopurinol	0.1	0.1	0.3	0.1	-0.5
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	0.2
Loneliness, isolation	0.1	0.2	0.2	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.3	-0.4
Hearing aid user	0.1	0.1	0.1	-0.1	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.5	0.0
Medication: Blood pressure	0.1	0.2	0.3	-0.6	0.2
Leg fat percentage (left)	0.1	0.2	0.4	-0.2	-0.6
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.5	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.6	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	-0.1	0.1
Triglycerides	0.0	0.0	0.1	0.2	0.2
Systolic Blood Pressure	0.0	0.1	0.1	-0.4	0.2
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.2
Vitamin and mineral supplements	0.0	0.1	0.1	-0.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.1	0.0
Lung cancer (father)	0.0	0.0	0.1	-0.3	0.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	-0.1	-0.1
Birth weight of first child	0.0	0.0	0.0	-0.1	-0.1
Birth weight	0.0	0.1	0.1	0.1	-0.4
Leg fat percentage (right)	0.0	0.1	0.2	-0.2	-0.4
Comparative body size at age 10	0.0	0.1	0.1	0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	0.3	0.1
Mean time to correctly identify matches	0.0	0.1	0.1	0.1	-0.4

Hub : Genes

SAMHD1

Models

Trait associations