Hub : Genes

SBF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.47 0.122 3.1e-03 0.025 NA 0.153 NA 0.039 5.0e-02 NA 1.1e-05 NA 2.0e-02
2 GTEx Cells Transformed fibroblasts 0.16 0.046 3.8e-06 0.136 NA 0.124 NA 0.143 2.3e-10 NA 1.5e-09 NA 6.8e-11
3 GTEx Prostate 0.21 0.087 4.4e-03 0.045 NA -0.005 NA 0.028 2.8e-02 NA 4.4e-01 NA 6.7e-02
4 GTEx Testis 0.10 0.046 9.3e-03 0.012 NA 0.000 NA 0.018 8.9e-02 NA 3.0e-01 NA 5.0e-02
5 GTEx Thyroid 0.11 0.042 1.5e-03 0.015 NA 0.066 NA 0.021 2.4e-02 NA 8.3e-06 NA 9.6e-03
6 NTR Blood 0.02 0.009 1.1e-03 0.001 0.007 0.005 0.007 0.003 1.0e-01 0.002 6.7e-03 0.0018 2.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Alzheimer’s Disease (in mother) 0.4 0.5 1.9 -0.3 0.3 -0.4 0.2 0.6 1.4
Alzheimer’s Disease (in father) 0.9 1.0 2.4 1.0 1.6 -0.8 1.1 -0.5 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 3.8 0.2 1.1 -0.4 0.3 0.2 2.0
Crohns Disease (2017) 1.1 2.5 7.8 0.3 -1.1 0.5 -0.4 -2.8 -2.3
Irritable Bowel Disease (IBD) 0.1 0.3 0.9 -0.0 -1.0 -0.0 0.2 -0.8 -0.1
Ulcerative Colitis (UC) 0.3 0.6 1.8 -0.3 -0.8 0.0 0.2 0.9 1.4
Major Depression (MDD) 0.4 0.5 2.4 0.2 0.4 0.4 -0.2 -0.1 -1.6
Reaction Time 0.7 1.3 5.1 -0.5 0.5 -0.6 0.5 -1.3 -2.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.4 0.6 0.5 -0.7 0.4 -0.8 -1.8
Breast Cancer 3.3 8.0 16.5 -0.4 -0.8 4.1 -4.1 -2.6 -2.8
Ovarian Cancer 0.5 0.7 2.5 1.6 0.4 -0.5 0.5 1.0 -0.2
Prostate Cancer 2.9 4.2 8.9 0.0 2.6 -3.0 2.7 0.7 1.3
Age at First Birth 0.5 0.7 3.3 -0.5 -1.8 -0.1 0.0 0.4 -0.8
Bipolar Disorder 1.0 1.0 2.3 -1.2 -0.6 1.0 -0.6 -0.4 -1.5
Body Mass Index (BMI) (2010) 0.4 0.5 1.7 0.2 -1.3 0.3 0.2 -0.5 1.0
Coronary Artery Disease (CAD) 0.1 0.1 0.4 0.2 -0.1 -0.3 0.4 -0.6 -0.3
Crohns Disease (2012) 0.6 0.9 2.5 0.9 0.2 0.4 -0.3 1.6 1.3
Mean Putamen Volume 0.9 1.0 3.6 -0.1 -1.9 0.8 -0.6 -1.0 -0.4
Fasting Glucose 0.6 0.7 1.3 -1.1 -1.1 -0.7 0.9 0.7 -0.3
HbA1C 4.3 4.8 10.1 0.9 3.2 -1.9 2.0 0.9 3.0
HDL Cholesterol 1.7 2.9 5.4 -0.1 1.1 -2.3 2.2 1.8 1.6
LDL Cholesterol 0.7 1.2 2.6 -0.3 0.8 1.6 -1.3 -0.5 -1.3
Lupus 0.5 0.7 1.2 -0.7 0.5 1.0 -1.1 -0.8 -0.8
Neuroticism 7.4 10.9 27.2 0.8 2.3 -4.8 5.2 0.9 2.9
Primary Biliary Cirrhosis 0.5 0.7 2.9 1.7 0.9 0.2 0.1 0.8 -0.3
Rheumatoid Arthritis 3.0 4.1 7.9 1.0 -2.4 2.8 -2.5 -0.6 -1.9
Schizophrenia 0.1 0.3 0.7 -0.8 0.4 0.4 -0.4 -0.6 -0.2
Triglycerides 1.0 1.6 3.5 0.1 -1.5 1.5 -1.0 -0.9 -1.9
Type 2 Diabetes (T2D) 0.3 0.4 1.1 0.5 -1.1 -0.6 0.5 0.5 -0.3
Ulcerative Colitis 0.9 1.4 3.4 -0.0 0.5 0.7 -1.1 -1.8 -1.7
Blood Eosinophil Count 0.3 2.4 5.8 -0.5 0.3 1.9 -2.2 0.1 -2.4
Blood Platelet Count 0.1 0.6 3.0 0.4 1.7 -0.3 0.4 0.1 0.6
Blood Red Count 6.1 59.7 174.2 0.8 -3.4 12.7 -13.2 -1.9 2.7
Blood White Count 0.8 6.2 27.7 -0.3 0.4 1.7 -1.5 -2.0 -5.3
Heel T-Score 0.6 4.5 8.1 -1.7 2.8 -2.8 2.4 0.9 1.4
BMI 0.2 1.0 3.2 1.0 -0.5 0.1 0.1 -1.8 -1.3
Height 1.2 23.9 66.1 2.3 0.6 7.5 -8.1 -3.5 -1.8
Waist Hip Ratio (WHR) 7.1 32.5 69.4 -0.6 5.6 -8.3 7.6 4.2 4.3
Systolic Blood Pressure 2.8 14.2 28.0 -0.1 -4.0 -3.9 5.1 -5.3 0.3
Smoking Status 0.2 0.6 1.9 0.3 1.2 -0.2 0.1 1.4 -0.1
Allergy or Eczema 1.3 3.4 6.5 -1.7 1.6 -2.6 2.1 0.1 -2.1
Cardiovascular Disease 1.6 5.2 10.1 -1.5 -2.5 -2.0 2.1 -3.2 -2.0
Hypothyroidism (self reported) 0.8 1.9 3.4 1.0 -1.8 1.8 -1.6 -1.1 -0.4
Respiratory disease 0.2 0.4 0.8 0.4 0.5 -0.8 0.9 -0.8 0.5
Type 2 Diabetes (T2D) 1.0 1.9 4.0 -0.9 0.9 -2.0 1.8 1.5 -0.3
Lung FEV1/FVC ratio 2.9 14.7 34.2 1.3 4.2 -5.8 5.8 0.7 -0.7
Lung FVC 0.2 1.2 3.1 0.7 -1.8 1.4 -0.9 -0.3 -1.0
Neuroticism 4.9 12.1 26.5 -1.7 4.5 -5.1 4.7 1.0 0.9
Chronotype (morning person) 0.5 1.2 1.6 -0.9 -0.7 1.2 -1.2 -1.1 -1.3
Hair Pigment 0.6 17.5 46.5 0.0 -3.2 6.8 -6.8 -0.8 -1.4
Tanning 0.2 2.4 7.0 0.3 0.5 -2.1 2.6 -0.6 1.6
Hand grip strength (left) 1.2 3.3 9.0 -0.2 0.9 -3.0 2.9 1.1 0.4
Number of treatments/medications taken 0.3 0.6 0.9 0.8 -0.3 1.0 -0.8 0.8 0.7
Average weekly spirits intake 0.6 0.8 2.6 0.9 1.6 0.5 -1.0 0.2 0.1
Sensitivity / hurt feelings 2.7 4.8 10.3 0.9 -3.2 2.9 -2.9 -0.5 -1.0
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.3 2.3 -0.9 1.8 -1.8 -0.5 1.3
Hearing difficulty/problems: Yes 1.2 1.8 3.3 -0.9 0.0 -1.8 1.7 1.7 1.1
Relative age of first facial hair 2.2 4.6 7.8 -2.0 1.1 -2.6 2.6 2.8 1.2
Other serious medical condition/disability diagnosed by doctor 3.7 4.8 7.9 1.8 -2.8 2.8 -2.5 -1.5 -1.3
Ever used hormone-replacement therapy (HRT) 0.8 1.1 3.8 0.2 -1.0 -0.8 1.0 -0.0 -2.0
Ever had hysterectomy (womb removed) 2.2 2.5 6.0 -0.1 -0.6 2.3 -2.4 -0.1 -1.9
Systolic blood pressure, automated reading 3.0 9.0 19.8 -0.2 2.9 3.5 -4.5 2.7 -2.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 -0.0 0.5 0.3 -0.4 -0.5 0.2
Angina 0.7 0.9 1.7 1.3 -0.2 0.5 -0.5 -1.2 1.3
Medication for hormone replacement therapy 0.8 1.0 2.2 -0.4 0.7 -1.5 1.5 0.1 -0.8
Vitamin and mineral supplements 1.0 1.4 2.2 1.4 -1.2 1.0 -1.1 -0.9 -1.5
Supplements: Zinc 0.8 0.9 3.5 -0.5 0.3 -0.6 1.0 0.1 1.9
Medication: Co-codamol 0.4 0.4 1.2 0.4 -1.1 0.7 -0.7 0.4 -0.1
Medication: Metformin 0.1 0.2 0.5 0.1 0.2 0.1 -0.1 0.7 0.7
Diabetes (father) 1.2 1.5 2.7 1.4 -0.6 1.5 -1.3 -1.6 -0.1
Diabetes (mother) 0.6 0.8 2.0 0.3 -0.3 1.4 -1.3 -0.9 0.1
Severe depression (siblings) 1.1 1.3 3.4 -1.2 0.6 0.5 -0.9 1.8 1.2
Pack years adult smoking proportion 0.7 1.1 3.3 0.8 0.5 -0.6 0.5 1.8 1.3
Impedance of leg (right) 4.6 22.9 49.8 1.4 -6.6 7.1 -5.8 -2.1 -2.1
Leg fat-free mass (left) 2.1 11.1 24.2 -2.4 2.7 -4.9 4.4 2.5 2.0
Trunk fat percentage 3.1 12.8 31.5 -0.7 -4.0 5.6 -5.2 -0.9 -0.9
Hand grip strength (right) 0.9 2.6 6.7 1.1 1.2 -2.6 2.4 0.8 0.1
Townsend deprivation index at recruitment 2.1 3.0 4.8 -0.3 -1.9 2.1 -2.2 -1.7 -1.6
Current tobacco smoking 0.5 0.7 3.7 0.0 -1.9 0.6 -0.6 -0.2 0.1
Average weekly fortified wine intake 0.6 0.8 2.4 1.6 -0.8 0.0 0.2 0.6 -1.1
Maternal smoking around birth 0.4 0.6 1.4 -0.2 -0.4 0.9 -1.1 -0.3 -1.2
Fed-up feelings 1.0 1.9 4.2 0.0 -2.0 2.1 -1.8 -0.3 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 3.9 2.0 -1.3 1.7 -1.6 -0.5 0.2
Relative age voice broke 1.8 2.9 7.0 -0.4 -0.0 -2.4 2.6 2.1 0.3
Taking other prescription medications 1.2 1.9 5.2 1.0 -1.1 2.3 -2.0 -0.0 0.0
Age when periods started (menarche) 0.4 1.0 2.5 -0.3 1.1 0.2 -0.4 1.4 1.6
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.8 -0.6 -1.4 1.1 -1.1 -0.2 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 4.8 -1.6 -2.2 1.2 -0.9 -0.5 -1.2
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.5 -0.4 0.5 -0.5 0.3 2.1 2.1
Qualifications: CSEs or equivalent 0.3 0.4 1.3 -0.0 -0.3 0.8 -0.6 -1.2 0.4
Serious illness, injury or assault to yourself 0.9 1.1 2.0 0.9 0.2 1.0 -1.1 -1.4 -1.1
High blood pressure 1.3 3.6 9.3 0.1 1.7 2.7 -3.0 1.4 0.1
Hayfever, allergic rhinitis or eczema 1.3 2.8 5.1 1.3 -1.8 2.0 -1.5 -0.3 2.3
Multivitamins +/- minerals 0.6 0.8 2.0 -1.4 0.8 -0.3 0.2 0.7 1.2
Stomach or abdominal pain in last month 0.3 0.3 1.2 0.1 -0.6 0.1 -0.2 0.7 -1.1
Supplements: Glucosamine 0.5 0.6 1.2 -0.5 -0.9 -0.7 1.1 0.4 -0.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.0 -0.7 -1.7 1.4 -1.1 0.3 0.3
Medication: Atenolol 0.1 0.2 0.4 0.3 0.5 0.4 -0.7 -0.2 0.3
Medication: Levothyroxine sodium 0.1 0.1 0.3 0.1 0.2 -0.5 0.5 -0.1 0.3
Sitting height 1.7 12.0 22.3 -3.9 -0.5 -4.4 4.7 3.0 2.3
Chronic bronchitis/emphysema (father) 1.0 1.2 2.5 0.9 -0.6 0.9 -0.9 -1.4 -1.6
High blood pressure (mother) 0.3 0.5 0.7 -0.6 0.8 0.6 -0.7 0.5 0.9
Body mass index (BMI) 0.1 0.6 1.4 -1.2 0.4 0.5 -0.8 0.8 0.8
Impedance of leg (left) 4.1 20.5 46.0 1.5 -5.8 6.8 -5.7 -2.0 -2.2
Leg predicted mass (left) 2.1 11.1 24.2 -2.3 2.8 -4.9 4.4 2.5 2.0
Trunk fat mass 0.9 4.1 8.7 -1.3 -2.7 2.9 -2.7 0.1 0.0
Waist circumference 0.2 0.9 1.3 -1.1 -0.8 1.1 -1.0 0.8 0.7
Number of incorrect matches in round 0.3 0.5 1.1 0.7 1.1 -0.7 0.3 -0.1 0.8
Past tobacco smoking 0.3 0.6 0.9 -0.9 0.9 -0.5 0.4 0.9 -0.6
Alcohol usually taken with meals 0.8 1.3 3.4 0.2 -0.8 -1.4 1.8 0.9 0.8
Nervous feelings 4.8 9.1 22.9 1.1 -3.0 4.8 -4.5 -0.9 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.4 1.5 -1.5 1.4 -1.5 -0.7 -0.2
Hearing difficulty/problems with background noise 0.5 0.8 2.2 -1.4 -1.5 -0.0 0.2 0.8 0.0
Hair/balding pattern: Pattern 2 0.9 1.1 2.5 -0.3 -0.0 1.3 -1.3 1.6 0.8
Had menopause 0.2 0.3 1.4 0.2 0.1 0.1 0.1 -0.5 -1.2
Had other major operations 1.2 1.5 3.0 0.2 -1.4 1.4 -0.8 -1.3 -1.7
Forced vital capacity (FVC) 0.5 1.9 5.8 -2.4 0.8 -1.5 1.2 0.8 0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 6.5 -2.5 -1.9 1.3 -1.2 -1.1 -0.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.0 0.6 -1.0 0.1 0.2 -0.1 -0.6
Qualifications: None of the above 0.5 1.0 1.8 0.6 -1.0 -1.3 1.4 0.4 1.1
Financial difficulties in last 2 years 0.9 1.2 3.6 1.9 -0.6 0.9 -1.1 -0.5 1.0
Mouth/teeth dental problems 2.6 3.9 15.4 -0.6 3.9 -2.2 1.6 0.1 0.5
Heart attack 1.0 1.3 2.5 1.1 1.6 -1.3 1.2 0.6 0.6
Allergy 0.2 0.5 1.2 -0.4 0.9 -1.1 0.6 0.3 -0.7
Pain all over the body in last month 0.9 1.0 3.4 0.5 1.1 -0.6 1.0 -0.2 1.8
Diabetes (self-reported) 0.6 1.0 2.9 0.2 0.2 1.5 -1.7 -0.4 -0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 1.1 0.9 0.5 -0.3 -0.2 -0.2
Medication: Ramipril 0.5 0.6 1.4 -1.2 0.5 -0.5 0.3 0.8 1.1
Medication: Simvastatin 0.7 1.0 4.3 -0.3 -0.3 0.4 0.1 2.1 1.3
Fluid intelligence score 0.7 1.6 5.1 -0.7 -1.5 0.6 -0.2 1.1 2.3
Illnesses of siblings 0.2 0.3 0.5 0.4 -0.1 -0.5 0.7 -0.7 -0.6
Neuroticism score 4.6 9.8 22.1 0.9 -3.9 4.7 -4.4 -0.2 -1.0
Weight 0.5 2.7 4.5 -2.1 0.3 -1.8 1.7 1.9 1.5
Impedance of arm (right) 5.4 25.6 62.6 0.8 -4.8 7.9 -7.2 -3.4 -2.0
Arm fat percentage (right) 2.0 8.2 20.5 -1.2 -2.4 4.5 -4.5 -0.8 -0.3
Trunk fat-free mass 4.8 27.9 65.1 -2.8 3.6 -8.1 7.7 3.6 2.9
Hip circumference 2.0 8.6 12.5 -2.0 1.8 -3.5 3.3 3.1 3.5
Time employed in main current job 0.9 1.0 4.2 0.3 -0.5 0.6 -0.4 -2.0 -1.0
Alcohol intake versus 10 years previously 1.0 1.4 4.9 -1.5 2.2 -0.9 0.5 0.6 0.5
Father’s age at death 0.3 0.5 1.2 -0.5 0.2 -1.1 1.1 0.4 0.1
Worrier / anxious feelings 2.4 4.7 9.7 1.8 -2.3 2.8 -3.1 0.7 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 4.2 1.0 -1.3 2.1 -1.9 -1.9 -0.0
Falls in the last year 2.2 3.0 7.2 0.9 -1.6 2.7 -2.6 -0.9 -0.0
Hair/balding pattern: Pattern 3 1.0 1.6 3.6 -1.6 -0.8 1.7 -1.9 -0.3 -0.3
Number of live births 0.6 0.8 2.7 1.0 -0.1 0.7 -1.0 -1.7 -0.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 5.3 -2.3 -0.7 1.1 -1.4 -0.1 0.8
Pulse rate 2.7 4.5 9.6 -0.2 -0.5 2.3 -2.2 -2.7 -3.1
Happiness 2.0 2.4 5.2 1.9 0.5 2.0 -2.3 -0.4 -1.1
Noisy workplace 0.6 0.8 1.6 1.2 1.3 -0.9 0.6 -0.5 0.1
Qualifications: A levels/AS levels or equivalent 0.5 1.1 5.4 -2.3 0.5 -0.5 0.6 -0.1 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.8 1.0 -0.4 1.4 -1.3 -1.2 -1.9
Mouth/teeth dental problems: Dentures 0.8 1.3 4.6 -1.0 -2.1 1.1 -0.7 -0.7 0.4
Asthma 0.3 0.6 1.8 -1.4 -0.0 0.0 -0.1 1.3 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -0.3 -0.7 -0.8 1.1 -1.0 -0.6
Medication: Cholesterol lowering 0.6 0.9 2.9 -0.3 0.1 -0.5 0.6 1.4 1.7
Depression (self-reported) 0.6 0.7 2.5 -0.3 -1.3 -0.1 0.1 1.6 -0.4
Medication: Lansoprazole 0.5 0.6 1.3 1.1 -0.9 0.4 -0.4 -0.0 -1.1
Prospective memory result 0.3 0.4 0.6 0.0 0.6 -0.8 0.8 0.8 0.5
Lung cancer (father) 1.2 1.4 3.1 0.1 0.3 1.4 -1.8 -0.6 -1.7
Illnesses of mother 0.2 0.2 0.5 -0.1 -0.7 -0.2 0.6 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.2 -1.5 -0.1 0.2 -0.4 0.1 1.3
Pulse wave Arterial Stiffness index 1.6 1.9 6.4 2.5 0.9 0.9 -0.9 -1.6 -0.1
Impedance of arm (left) 5.1 24.0 58.0 0.7 -5.2 7.6 -7.0 -2.7 -1.7
Arm fat mass (right) 0.4 1.6 2.9 -1.5 -1.1 1.6 -1.7 0.5 0.7
Trunk predicted mass 4.7 27.5 64.6 -2.7 3.6 -8.0 7.7 3.6 2.8
Standing height 1.3 12.7 31.9 -2.5 0.0 -5.2 5.7 2.7 1.8
Length of working week for main job 0.4 0.5 1.7 1.3 -1.0 0.1 0.0 0.3 -0.2
Exposure to tobacco smoke at home 0.6 0.7 1.8 -1.3 0.7 -0.9 0.9 0.2 0.5
Breastfed as a baby 1.1 1.3 3.1 -1.8 0.2 1.3 -1.1 -1.1 0.8
Tense / ‘highly strung’ 1.7 2.9 7.6 0.7 -1.1 2.7 -2.8 -0.3 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.7 1.6 -0.5 1.6 -1.5 0.2 -1.1
Hair/balding pattern: Pattern 4 0.8 2.1 3.2 1.4 -1.4 1.7 -1.5 -1.8 -0.2
Birth weight of first child 1.2 2.2 7.7 -2.8 -1.2 -1.0 1.0 -0.5 -1.3
Peak expiratory flow (PEF) 2.1 4.9 8.8 -1.3 -2.7 3.0 -2.9 -1.7 0.7
Pulse wave reflection index 2.1 2.6 6.4 1.9 -0.1 1.7 -1.5 -2.5 0.0
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.2 0.9 0.5 1.1 -1.0 0.4 -0.4
Loud music exposure frequency 0.2 0.3 1.1 -0.4 -0.1 0.4 -0.3 -0.3 1.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.3 -0.8 1.1 0.9 -1.0 0.7 0.2
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 9.2 0.8 -3.0 0.6 -0.4 0.5 -1.8
Blood clot in the leg (DVT) 0.4 0.5 2.2 -0.1 0.1 -0.4 0.6 -0.5 -1.5
Medication: Paracetamol 1.7 2.8 4.4 1.7 -1.8 2.1 -1.8 -1.7 -0.5
Headache pain in last month 0.4 0.7 2.0 -1.2 -1.4 0.1 -0.0 0.6 -0.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.3 0.0 -0.4 -0.5 0.4 -0.3 -1.5
Glaucoma (self-reported) 1.1 1.3 5.0 0.2 -2.2 1.0 -1.0 0.2 0.8
Gout (self-reported) 1.5 2.1 10.0 -1.3 3.2 0.4 -0.7 0.0 0.5
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.6 -0.1 1.6 -0.9 0.6 -0.0 0.1
Medication: Amlodipine 0.7 1.0 3.0 -1.2 0.1 0.9 -0.9 1.7 -0.2
Medication: Ventolin 100micrograms inhaler 1.5 1.9 4.0 -0.5 -1.9 2.0 -1.6 0.9 -0.2
Birth weight 2.1 4.7 11.2 -0.9 -0.7 -2.8 3.4 1.7 2.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.3 1.1 0.3 0.5 -0.7 -1.0 -1.1
High blood pressure (siblings) 0.7 1.0 2.5 -1.1 0.4 1.4 -1.6 0.0 0.5
Forced vital capacity (FVC), Best measure 0.6 2.1 3.5 -1.5 0.8 -1.9 1.7 0.9 1.6
Body fat percentage 3.1 12.6 31.1 -0.7 -3.8 5.6 -5.3 -1.0 -0.8
Leg fat percentage (right) 3.1 11.5 27.6 -0.8 -3.8 5.2 -4.9 -1.2 -0.7
Arm fat-free mass (right) 3.6 18.7 44.6 -1.9 2.9 -6.7 6.4 3.1 2.3
Exposure to tobacco smoke outside home 1.3 1.7 3.6 -1.2 -1.9 1.6 -1.2 0.7 1.0
Comparative body size at age 10 0.4 1.2 2.9 -0.3 1.6 -1.1 0.8 -0.2 1.7
Number of full brothers 0.6 0.8 2.7 -0.3 0.1 -0.6 0.7 1.6 1.0
Worry too long after embarrassment 4.1 6.9 13.5 -0.6 -3.7 3.7 -3.6 0.0 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.8 -0.3 0.9 -0.5 -0.4 0.1
Wheeze or whistling in the chest in last year 0.2 0.3 0.9 0.1 -0.7 0.5 -0.4 0.2 1.0
Number of children fathered 0.4 0.5 1.5 1.2 0.5 0.1 0.3 0.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.8 0.0 -0.1 0.4 -0.3 0.2 -1.4
Age at first live birth 1.6 2.9 5.0 -1.6 1.9 -2.2 1.9 1.6 0.9
Pulse wave peak to peak time 2.1 2.5 7.0 -2.6 -1.1 -1.2 1.4 1.9 0.3
Health satisfaction 3.0 3.9 5.8 2.4 -2.2 2.3 -2.0 -0.1 -1.7
Shortness of breath walking on level ground 2.4 2.9 5.8 0.9 -1.7 2.4 -2.4 -1.0 -1.0
Qualifications: College or University degree 0.4 1.2 2.9 -0.3 -1.4 -0.2 0.7 1.7 -1.4
Eye problems/disorders: None of the above 1.8 2.1 4.5 -0.6 1.8 -2.1 2.0 0.6 0.8
Mouth/teeth dental problems: Loose teeth 1.3 1.6 3.3 1.5 -1.0 1.8 -1.5 -0.2 0.6
Emphysema/chronic bronchitis 0.6 0.7 1.5 1.1 0.6 -1.1 1.2 -0.0 0.0
Medication for pain relief, constipation, heartburn 0.2 0.3 1.3 -0.1 0.2 0.2 -0.1 1.1 -0.4
Neck or shoulder pain in last month 0.3 0.5 1.5 -0.1 -0.2 0.3 -0.6 1.2 -0.9
Medication: Blood pressure 0.1 0.3 0.5 0.7 0.6 -0.0 -0.3 -0.4 0.7
Angina (self-reported) 0.7 0.8 1.5 1.1 -0.4 0.6 -0.6 -1.2 1.2
Migraine (self-reported) 0.7 0.8 2.1 -0.1 -0.5 1.2 -1.1 -1.5 -0.1
Medication: Ibuprofen 0.6 0.7 1.8 0.5 -0.6 -1.0 1.3 -0.8 0.5
Medication: Allopurinol 0.9 1.2 5.4 -0.5 2.3 0.5 -0.9 0.6 0.2
Medication: Omeprazole 0.6 0.7 3.6 0.5 -0.7 0.2 -0.3 -0.0 -1.9
Medication: Seretide 50 evohaler 0.1 0.2 0.4 -0.1 0.4 -0.3 0.4 0.6 -0.4
Mean time to correctly identify matches 0.2 0.4 1.9 0.5 -0.2 0.3 -0.3 0.5 1.4
Heart disease (mother) 1.9 2.3 6.3 -0.6 -0.4 2.3 -2.5 -1.2 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 1.5 0.5 1.2 0.8 -1.2 0.3 -1.2
Whole body fat mass 0.7 3.0 6.5 -1.1 -2.0 2.5 -2.4 0.4 0.3
Leg fat mass (right) 0.6 2.4 5.3 -1.2 -1.8 2.3 -2.2 0.1 0.5
Arm predicted mass (right) 3.5 18.2 42.7 -2.1 2.8 -6.5 6.2 3.2 2.3
Pulse rate, automated reading 4.2 13.6 21.6 -1.7 -2.1 4.7 -4.4 -4.5 -3.6
Alcohol intake frequency. 0.4 1.0 2.8 -0.9 0.1 -1.6 1.7 0.1 0.1
Comparative height size at age 10 0.3 1.9 4.4 -1.7 0.0 -2.1 2.0 0.2 -0.5
Number of full sisters 1.2 1.5 4.3 -0.7 -1.8 0.1 0.2 -1.0 2.1
Suffer from ‘nerves’ 3.2 5.1 9.9 1.6 -2.4 3.1 -2.9 -1.2 -1.7
Overall health rating 1.5 3.3 6.0 2.5 -1.4 2.2 -1.9 -1.2 -1.4
Chest pain or discomfort 0.9 1.3 3.0 0.5 -0.8 1.6 -1.7 1.2 0.1
Had major operations 1.4 1.7 3.3 1.4 -0.8 1.5 -1.8 -1.0 -0.8
Age at last live birth 0.6 0.9 2.3 -0.9 1.1 -0.6 0.4 0.7 1.5
Family relationship satisfaction 0.8 1.0 2.7 1.6 0.6 0.5 -0.5 1.3 -0.7
Leg pain on walking 0.6 0.7 1.9 -0.5 -0.8 -0.3 0.2 1.2 1.4
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 3.8 -0.4 -1.7 1.6 -1.6 -2.0 -1.7
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.2 0.7 -0.3 1.0 -0.4 -1.8 0.7
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 7.5 -2.7 0.8 -0.2 0.2 0.8 0.3
Medication: Aspirin 0.4 0.5 1.8 0.5 0.6 0.2 -0.5 0.7 1.3
Supplements: Vitamin C 0.1 0.1 0.2 -0.5 0.0 -0.1 0.1 -0.5 0.2
Knee pain experienced in last month 0.8 1.2 2.7 -0.0 -1.0 1.6 -1.2 -1.0 -1.1
Hypertension (Self-reported) 1.3 3.7 9.2 1.0 1.5 2.7 -3.0 1.5 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.0 1.0 -0.9 -0.1 -0.1 0.8 -0.9
Illnesses of father: Heart disease 0.9 1.3 2.7 1.7 0.1 -0.6 0.4 -1.5 -1.4
Illnesses of siblings: Diabetes 1.8 2.3 4.3 0.4 -1.7 1.8 -2.1 -0.5 -1.7
Smoking status: Previous 0.2 0.3 1.3 0.4 0.1 0.2 -0.4 -1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 6.9 0.1 1.2 -2.4 2.6 -0.4 -1.0
Whole body fat-free mass 3.8 22.3 51.7 -2.6 3.5 -7.2 6.8 3.4 2.5
Leg fat-free mass (right) 2.5 13.8 30.7 -2.3 3.5 -5.5 4.9 2.6 2.0
Arm fat percentage (left) 2.0 8.0 20.0 -1.3 -2.5 4.5 -4.5 -0.5 -0.1
Average weekly red wine intake 0.5 0.7 2.5 0.3 -0.3 -0.7 0.9 0.6 1.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 -0.6 -0.6 -0.2 0.3 -0.8 -0.7
Mood swings 0.5 0.9 2.1 0.9 -0.0 1.5 -1.4 0.6 -0.1
Loneliness, isolation 0.8 1.1 2.5 -0.2 -1.6 1.3 -1.3 -0.5 0.4
Long-standing illness, disability or infirmity 0.6 0.9 2.7 0.5 -0.6 1.1 -1.0 -1.6 0.1
Ever had bowel cancer screening 1.1 1.3 2.9 1.7 -1.2 0.6 -0.4 -1.7 0.2
Diabetes diagnosed by doctor 0.5 0.8 2.2 0.5 0.3 1.3 -1.5 -0.5 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 0.8 1.1 -0.3 -0.1 -0.4 0.6
Friendships satisfaction 0.9 1.2 1.7 1.3 -0.7 1.3 -1.1 1.2 -0.7
Qualifications: nursing, teaching 0.3 0.5 0.9 -0.4 0.9 -0.7 0.9 0.8 -0.1
Commuting to job workplace: Walk 0.5 0.5 1.3 -0.3 1.1 -0.9 0.4 0.6 0.6
Eye problems/disorders: Cataract 1.2 1.4 2.5 0.3 -0.5 1.5 -1.6 -1.0 -1.5
Mouth/teeth dental problems: Mouth ulcers 1.8 2.9 9.3 -0.3 -3.1 2.0 -1.6 -1.0 -0.6
Medication for cholesterol 0.9 1.4 3.2 0.9 -1.8 -0.9 0.9 -1.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.0 1.2 0.4 -1.0 0.9 1.7 1.7
Back pain experienced in last month 0.5 0.8 2.5 0.2 -1.6 0.5 -0.3 -0.6 -1.2
Mineral and other dietary supplements 0.2 0.2 0.7 0.3 -0.2 0.5 -0.9 0.3 0.2
Breast cancer (self-reported) 1.4 1.7 2.8 -1.4 -0.9 1.6 -1.7 -1.3 -0.4
Asthma (self-reported) 0.3 0.7 2.2 -1.5 -0.0 0.1 -0.2 1.3 0.4
Osteoporosis (self-reported) 0.7 0.8 3.0 -0.8 0.4 -0.7 0.7 0.0 1.7
Osteoarthritis (self-reported) 0.6 0.7 2.5 0.0 -0.9 0.6 -0.5 -0.7 -1.6
Medication: Aspirin 0.2 0.3 0.6 0.5 0.6 0.3 -0.6 0.8 0.5
Medication: Gliclazide 0.9 1.0 2.6 -0.3 -1.6 1.4 -1.1 -0.3 0.5
Illnesses of father: None of the above (group 1) 0.2 0.3 0.7 0.8 -0.8 0.5 -0.2 0.1 -0.3
Smoking status: Current 0.3 0.4 2.2 0.1 -1.5 0.4 -0.4 0.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.6 -1.3 0.1 0.7 -1.1 -0.5 -0.4
Whole body water mass 3.9 22.7 52.7 -2.7 3.6 -7.3 6.8 3.3 2.5
Leg predicted mass (right) 2.4 13.3 29.5 -2.4 3.5 -5.4 4.7 2.5 1.9
Arm fat mass (left) 0.4 1.7 3.0 -1.6 -1.0 1.7 -1.7 0.6 0.8
Number of self-reported non-cancer illnesses 1.4 2.4 4.8 1.7 -1.2 2.2 -2.2 0.7 0.5
Average weekly champagne plus white wine intake 0.2 0.3 0.7 -0.8 0.8 -0.4 0.1 0.4 0.3
Miserableness 1.5 2.7 7.2 0.5 -2.0 2.7 -2.0 0.1 0.7
Guilty feelings 1.1 1.6 2.9 0.8 -1.6 1.5 -1.7 1.1 -0.7
Wears glasses or contact lenses 1.8 2.0 6.0 -0.5 -2.5 0.9 -0.5 1.0 -2.0
Ever taken oral contraceptive pill 1.1 1.2 2.1 -0.3 -1.1 1.3 -1.3 -1.5 -0.5
Hearing aid user 2.4 2.8 8.4 0.4 0.1 -2.8 2.9 0.0 0.5
Mother’s age at death 0.1 0.2 0.5 0.7 0.6 0.1 -0.0 -0.2 -0.2
Financial situation satisfaction 0.8 0.9 2.9 1.7 0.3 0.6 -0.6 0.5 1.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.8 1.7 0.4 0.4 -0.3 -0.8 0.3
Commuting to job workplace: Public transport 0.3 0.4 0.9 -0.2 -0.9 0.7 -1.0 -0.3 -0.4
Eye problems/disorders: Glaucoma 1.6 1.9 4.0 0.8 -2.0 1.6 -1.6 0.2 1.3
Medication: Blood pressure 1.9 3.6 8.4 -0.6 2.0 2.8 -2.9 1.0 -0.4
Pain type(s) experienced in last month: Hip pain 1.4 1.8 3.2 1.4 -1.8 1.4 -1.4 -1.1 -0.4
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.0 -0.5 -0.3 -1.4 1.7 0.3 0.5
High cholesterol (Self-reported) 0.7 1.3 2.6 0.8 0.9 -0.6 1.0 1.5 1.6
Medication: Bendroflumethiazide 1.0 1.5 4.7 -0.8 1.7 0.5 -1.0 2.2 0.1
Medication: Paracetamol 2.4 3.7 5.9 1.8 -2.3 2.4 -2.2 -1.9 -0.1
Medication: Lisinopril 1.8 2.4 4.8 2.2 0.6 2.0 -2.1 0.7 0.4
Medication: Atorvastatin 1.0 1.3 3.4 -0.5 0.4 0.7 -0.8 1.6 1.9
Illnesses of father: High blood pressure 1.6 2.0 3.5 -0.4 1.9 -1.5 1.3 1.4 1.6
Alcohol drinker status: Never 0.8 1.0 3.3 -0.1 0.4 -1.5 1.8 0.3 0.3
Ever smoked 0.5 0.8 2.6 0.3 -1.6 0.9 -0.6 -0.2 1.1
Basal metabolic rate 2.7 15.5 34.1 -2.6 2.8 -5.8 5.5 3.0 2.4
Leg fat percentage (left) 2.6 9.6 23.5 -0.8 -3.2 4.8 -4.7 -1.0 -0.5
Arm fat-free mass (left) 3.4 17.5 40.5 -1.9 3.1 -6.4 6.1 3.0 2.3
Number of operations (self-reported) 2.0 3.0 7.5 1.0 -2.7 1.6 -1.1 -1.5 -2.0
Average weekly beer plus cider intake 1.7 2.5 7.0 0.0 -0.4 2.6 -2.6 -0.2 -1.1
Irritability 1.9 3.3 7.4 1.2 -2.3 2.7 -2.3 -0.7 -0.2
Risk taking 0.4 0.6 1.2 0.2 0.5 -1.1 0.9 -0.4 1.0
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.6 1.6 0.3 -1.2 1.5 0.6 -1.1
Fractured/broken bones in last 5 years 0.3 0.4 1.0 0.9 -1.0 0.4 -0.2 0.3 -0.5
Age started oral contraceptive pill 0.2 0.3 0.5 0.6 0.2 0.5 -0.6 0.7 0.1
Diastolic blood pressure, automated reading 2.8 8.8 23.4 -1.0 1.8 4.0 -4.8 2.1 -2.1
Ever depressed for a whole week 0.1 0.2 0.4 0.4 -0.2 -0.2 0.3 -0.7 -0.6
Unable to work because of sickness or disability 1.5 2.0 5.2 1.1 -0.3 0.8 -0.7 -2.3 -2.0
Commuting to job workplace: Cycle 0.2 0.2 0.8 -0.6 -0.3 0.3 -0.3 -0.2 -0.9
Myopia 1.1 1.7 4.1 0.7 -2.0 1.0 -0.7 -2.0 -0.3
Vascular/heart problems diagnosed by doctor 0.8 2.3 5.7 -0.1 -1.8 -2.0 2.4 -1.1 -0.2
Cholesterol lowering medication 0.9 1.3 6.5 -0.2 1.0 -0.1 0.1 2.6 0.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 4.1 0.0 -1.2 0.6 -0.7 0.5 -2.0
Pain experienced in last month 1.1 1.9 4.2 0.6 1.7 -1.4 1.4 0.4 2.0
Supplements: Calcium 1.1 1.2 3.4 -1.9 -0.1 -1.2 1.6 -0.2 0.1
Basal cell carcinoma (self-reported) 1.7 2.1 4.7 -0.0 -0.7 2.2 -2.1 -1.6 0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.8 2.3 1.0 1.5 -0.8 0.7 0.6 0.4
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.7 0.0 -0.2 -0.0 0.3 -0.9 -1.6
Heart disease (siblings) 0.5 0.7 1.4 -0.3 0.8 -1.2 1.0 -0.5 0.8
Alcohol drinker status: Previous 0.9 1.0 4.2 -0.6 -2.1 -0.6 0.7 0.1 -0.8
Pack years of smoking 0.8 1.2 3.5 0.8 0.8 -0.8 0.6 1.9 1.1
Impedance of whole body 5.8 30.3 70.7 1.7 -6.3 8.4 -7.4 -3.0 -2.4
Leg fat mass (left) 0.5 1.9 4.1 -1.0 -1.5 2.0 -2.0 0.2 0.5
Arm predicted mass (left) 3.2 16.8 39.9 -1.9 2.8 -6.3 6.0 2.9 2.0