TWAS hub - SCARA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.360	0.0640	7.0e-12	0.209	NA	0.230	NA	0.141	1.0e-11	NA	6.9e-13	NA	3.4e-08
2	GTEx	Artery Tibial	0.124	0.0431	8.3e-04	0.030	NA	0.029	NA	0.027	1.9e-03	NA	2.2e-03	NA	3.0e-03
3	GTEx	Colon Transverse	0.245	0.0960	8.8e-03	0.010	NA	-0.001	NA	-0.001	1.0e-01	NA	3.5e-01	NA	3.4e-01
4	GTEx	Esophagus Muscularis	0.124	0.0500	2.6e-03	0.096	NA	0.037	NA	0.065	1.9e-06	NA	2.7e-03	NA	8.3e-05
5	GTEx	Thyroid	0.202	0.0460	9.0e-08	0.153	NA	0.154	NA	0.151	9.5e-12	NA	7.4e-12	NA	1.2e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alzheimer’s Disease (including proxy)	4.5	6.5	13.5	-2.3	-3.0	3.7	1.4	1.6
Alzheimer’s Disease (in mother)	3.9	4.6	6.9	-2.3	-2.6	1.9	2.1	1.7
Fasting Glucose	3.9	4.7	9.0	-0.8	-0.6	2.8	3.0	2.3
Diabetes (father)	3.9	4.9	11.8	-0.7	-0.5	-1.3	3.4	3.2
Happiness	3.4	4.2	8.6	1.2	1.3	0.6	-2.9	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	7.5	-2.2	-1.9	-2.7	0.4	1.4
High blood pressure (mother)	3.0	4.2	8.8	-2.1	-2.1	-0.0	1.9	3.0
Time employed in main current job	3.0	3.5	6.5	1.7	1.4	-0.9	2.5	2.3
Commuting to job workplace: Public transport	3.0	3.6	5.2	-1.5	-2.2	-1.6	1.8	2.3
Current tobacco smoking	2.3	3.7	9.0	-0.2	-0.1	0.9	-3.0	-3.0
Alcohol intake frequency.	2.3	5.4	16.3	4.0	2.7	-0.0	-0.9	-1.6
Hair/balding pattern: Pattern 2	2.2	2.8	12.7	-0.1	-0.3	3.6	-0.2	-1.1
Ever taken oral contraceptive pill	2.2	2.4	3.7	-1.2	-1.3	1.9	1.6	1.7
Medication: Ramipril	2.1	2.7	7.9	0.4	0.2	-1.0	-2.1	-2.8
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.7	1.3	1.9	1.2	1.2	1.7
Supplements: Calcium	2.0	2.2	3.1	-1.8	-1.1	1.4	1.4	1.6
Medication: Co-codamol	1.9	2.2	6.7	0.2	0.9	-2.6	-1.2	-1.3
Smoking status: Current	1.9	3.0	7.4	-0.2	-0.1	1.1	-2.7	-2.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	6.3	1.6	0.7	2.5	-1.1	-1.1
Bipolar Disorder or Schizophrenia	1.8	4.4	9.9	-3.1	-2.6	1.8	0.5	1.3
Diabetes diagnosed by doctor	1.8	3.0	7.0	1.8	1.2	-2.6	1.7	0.7
Medication: Gliclazide	1.8	2.0	5.6	1.0	1.0	-2.4	1.4	0.7
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.2	-1.7	-2.0	-1.2	-0.7	-0.9
Heart disease (siblings)	1.7	2.1	3.3	1.8	1.7	-0.8	-1.5	-1.3
Schizophrenia (2018)	1.6	3.3	6.2	-2.5	-2.5	1.8	0.4	1.0
HbA1C	1.6	1.8	5.3	1.0	1.1	2.3	-0.2	-1.2
Schizophrenia (2014)	1.6	3.5	9.1	-3.0	-2.7	0.9	-0.4	-0.1
Height	1.6	31.3	81.4	1.1	0.7	-0.6	-9.0	-8.6
Ever had hysterectomy (womb removed)	1.6	1.8	4.6	0.3	-0.7	2.1	1.5	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.9	0.9	1.7	-1.2	1.4	1.4
Eye problems/disorders: Cataract	1.6	1.9	3.0	1.7	1.3	-1.1	-0.9	-1.7
Mean Putamen Volume	1.5	1.7	4.3	0.4	-0.1	0.5	-2.1	-1.9
Townsend deprivation index at recruitment	1.5	2.1	6.6	-1.3	-1.4	-2.6	-0.1	-0.2
Standing height	1.5	14.8	36.9	1.4	1.3	-0.8	-6.1	-5.7
Loud music exposure frequency	1.5	1.7	4.1	0.9	0.4	0.6	2.0	1.7
Loneliness, isolation	1.5	2.1	4.3	2.1	1.3	0.6	1.7	1.1
Average weekly beer plus cider intake	1.5	2.2	5.1	-1.6	-1.8	-2.3	0.1	-0.1
Smoking Status	1.4	3.4	7.2	-1.2	-1.3	1.0	-2.7	-2.4
Medication: Levothyroxine sodium	1.4	2.4	6.4	1.2	0.9	0.8	-1.6	-2.5
Lung cancer (father)	1.4	1.6	7.2	0.0	-0.9	2.7	-0.4	-0.2
Pulse wave reflection index	1.4	1.8	4.5	-2.1	-0.6	-1.2	0.6	1.5
Comparative height size at age 10	1.4	7.5	18.1	1.7	1.5	-0.3	-3.8	-4.3
Illnesses of siblings: Diabetes	1.4	1.7	3.2	1.8	1.7	0.5	1.3	0.7
Ever had bowel cancer screening	1.4	1.6	3.6	-1.1	-1.9	1.8	0.1	-0.3
Ulcerative Colitis (UC)	1.3	2.5	6.2	-0.7	-0.4	-1.6	1.8	2.5
Major Depression (MDD)	1.3	1.6	5.4	-1.1	-2.3	-0.5	-0.8	-0.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.4	-0.2	-0.9	-1.8	1.6	0.4
Medication: Atenolol	1.3	1.6	3.7	0.4	0.8	-0.9	-1.6	-1.9
Diabetes (self-reported)	1.3	2.1	4.4	1.6	1.0	-2.1	1.5	0.3
Alcohol intake versus 10 years previously	1.3	1.9	3.2	-1.5	-1.8	-1.0	-1.4	-1.1
Prospective memory result	1.3	1.5	4.5	-0.4	-0.4	-2.1	1.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.2	-1.0	-1.8	-1.2	1.4	0.9
Shortness of breath walking on level ground	1.3	1.6	2.6	1.6	1.4	-0.2	-1.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.8	1.2	0.9	-0.4	-1.1	-2.0
Long-standing illness, disability or infirmity	1.3	2.0	2.6	-1.2	-1.6	-1.5	-1.3	-1.4
Number of self-reported non-cancer illnesses	1.3	2.2	5.8	-2.4	-2.2	-0.5	0.2	-0.2
Irritable Bowel Disease (IBD)	1.2	2.8	7.1	-1.9	-1.0	-2.7	0.6	1.5
Bipolar Disorder (2011)	1.2	1.2	2.6	-0.7	-0.0	-1.0	1.6	1.3
Hand grip strength (left)	1.2	3.1	7.4	0.7	1.1	0.3	-2.5	-2.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.2	-0.9	-0.5	-0.3	-1.5	-2.1
Vitamin and mineral supplements	1.2	1.7	5.5	1.5	2.3	-0.6	-0.0	-0.2
Diabetes (mother)	1.2	1.5	5.8	0.6	0.6	-2.4	0.9	-0.5
Hand grip strength (right)	1.2	3.3	7.6	0.7	0.9	0.7	-2.7	-2.8
Fed-up feelings	1.2	2.3	3.8	1.3	2.0	0.1	1.8	1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	4.5	-1.1	-1.0	-2.1	-0.5	-0.8
Gout (self-reported)	1.2	1.7	4.3	-0.4	-0.7	-0.9	-1.7	-2.1
Heart disease (mother)	1.2	1.5	4.9	0.5	1.3	-2.2	-0.3	-0.7
High cholesterol (Self-reported)	1.2	2.2	5.4	-2.3	-2.0	0.4	0.7	0.9
Reaction Time	1.1	2.0	3.7	-0.9	-0.9	-1.6	1.6	1.9
Primary Biliary Cirrhosis	1.1	1.6	3.6	-1.8	-1.0	1.9	-0.2	0.4
Sensitivity / hurt feelings	1.1	1.9	3.7	1.1	1.1	0.6	-1.9	-1.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.8	-0.2	-0.7	2.4	-0.4	-0.6
Multivitamins +/- minerals	1.1	1.4	3.3	-0.7	-0.9	0.4	-1.8	-1.5
Mouth/teeth dental problems	1.1	1.8	4.4	0.6	1.2	1.0	1.2	2.1
Breastfed as a baby	1.1	1.4	3.7	1.4	1.9	-1.0	-0.6	-0.3
Exposure to tobacco smoke outside home	1.1	1.4	2.5	-1.2	-1.3	-1.2	1.6	0.3
Hearing aid user	1.1	1.2	3.2	-1.5	-1.8	-0.2	0.8	0.2
Unable to work because of sickness or disability	1.1	1.4	3.3	0.6	0.7	0.7	1.5	1.8
Body Mass Index (BMI) (2010)	1.0	1.3	5.2	1.0	2.3	-0.3	0.5	0.3
Cardiovascular Disease	1.0	3.4	4.8	-2.1	-1.8	-0.2	2.2	2.1
Number of treatments/medications taken	1.0	1.8	4.5	-2.1	-1.7	-0.7	0.7	0.9
Supplements: Zinc	1.0	1.1	2.7	-1.0	-1.1	1.6	0.4	0.8
Chronic bronchitis/emphysema (father)	1.0	1.2	3.9	2.0	0.7	0.4	1.0	-0.7
Had other major operations	1.0	1.2	3.1	-1.8	-1.7	-0.3	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.5	-1.5	-1.3	-0.4	2.1	1.7
Migraine (self-reported)	1.0	1.2	2.8	-1.7	-1.5	0.8	-0.4	-0.2
Medication: Allopurinol	1.0	1.3	3.4	-0.0	-0.0	-0.4	-1.8	-1.7
Mean time to correctly identify matches	1.0	2.0	3.1	-0.9	-1.4	-1.6	1.2	1.8
Number of full sisters	1.0	1.2	3.4	0.5	0.7	-1.8	-1.0	-0.9
Had major operations	1.0	1.2	5.5	-0.6	-0.5	-2.4	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.0	0.1	-0.8	1.4	1.3	0.9
Crohns Disease (2017)	0.9	1.9	4.9	-2.2	-1.4	-1.6	-0.6	0.1
Ovarian Cancer	0.9	1.2	2.1	1.1	1.3	-0.4	1.4	0.9
Triglycerides	0.9	1.5	2.8	-1.3	-0.6	0.5	1.5	1.7
Allergy or Eczema	0.9	2.3	6.7	-1.5	-2.6	0.9	1.1	0.8
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.6	1.9	1.3	0.7	0.6	-0.1
Average weekly fortified wine intake	0.9	1.1	3.1	1.1	1.8	-0.1	1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.9	-1.4	-1.3	-0.6	2.0	1.5
Had menopause	0.9	1.1	3.0	0.9	0.5	1.7	-0.7	-0.9
Medication: Amlodipine	0.9	1.3	2.5	-1.3	-1.6	-0.9	1.0	0.8
Average weekly champagne plus white wine intake	0.9	1.2	2.7	-1.7	-1.0	0.6	1.0	1.1
Financial situation satisfaction	0.9	1.1	2.5	1.6	1.3	-0.1	-0.7	-0.8
Bipolar Disorder (2018)	0.8	1.3	3.9	-2.0	-1.1	0.6	0.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.0	1.1	0.8	1.4	0.7	0.7
Supplements: Glucosamine	0.8	1.0	2.4	-0.9	-0.5	0.3	1.2	1.5
Sitting height	0.8	5.7	13.3	1.2	0.6	-0.5	-3.6	-3.6
Forced vital capacity (FVC)	0.8	3.2	7.3	0.7	1.0	1.1	-2.7	-2.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.2	1.4	1.6	0.9	-2.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.1	-0.2	-0.1	0.2	1.5	1.7
Forced vital capacity (FVC), Best measure	0.8	3.0	9.4	-0.5	0.0	-0.9	-3.1	-2.1
Health satisfaction	0.8	1.1	1.6	1.3	1.2	0.9	-0.8	-0.9
Age at last live birth	0.8	1.2	2.1	0.6	0.6	-1.5	-1.1	-1.3
Leg pain on walking	0.8	0.9	2.1	1.4	1.0	-0.5	-0.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	0.5	0.2	0.1	1.7	1.2
Friendships satisfaction	0.8	1.0	3.2	0.6	0.9	1.8	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	1.7	1.7	0.6	0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.4	0.3	-0.1	-0.2	1.9	1.2
Mineral and other dietary supplements	0.8	1.1	3.0	-0.1	0.3	-1.1	-1.2	-1.7
Breast cancer (self-reported)	0.8	1.0	3.2	-0.8	-0.7	-1.8	-0.5	-0.4
Miserableness	0.8	1.4	4.2	0.1	0.2	-0.3	2.0	1.6
Wears glasses or contact lenses	0.8	0.9	1.7	0.8	0.6	-1.3	1.3	0.7
Diastolic blood pressure, automated reading	0.8	2.6	6.3	-0.5	0.7	-0.4	2.4	2.5
Schizophrenia vs Biploar Disorder	0.7	1.0	3.6	0.2	-0.4	-0.5	-0.9	-1.9
Breast Cancer	0.7	1.6	2.7	0.3	1.2	-1.6	1.5	1.2
Ulcerative Colitis	0.7	1.1	2.9	0.2	0.7	-1.7	1.0	1.0
Blood Red Count	0.7	7.2	16.6	3.9	4.1	-0.1	-0.3	-2.1
Relative age of first facial hair	0.7	1.3	3.5	-0.2	-0.6	0.6	1.6	1.9
Severe depression (siblings)	0.7	0.8	2.2	-1.5	-0.8	-0.0	0.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	1.3	1.1	-0.6	0.9	0.7
Age when periods started (menarche)	0.7	1.6	3.6	1.1	0.8	-1.2	-1.9	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.8	-0.2	0.1	-1.7	1.0	0.1
Nervous feelings	0.7	1.4	3.2	-0.3	-1.7	1.8	-0.5	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	3.1	1.2	1.0	1.8	0.3	0.3
Falls in the last year	0.7	1.0	2.1	-1.4	-1.4	0.9	0.1	-0.3
Hair/balding pattern: Pattern 4	0.7	1.7	3.7	0.9	1.7	-1.9	-0.9	-0.8
Number of full brothers	0.7	0.9	2.3	1.5	1.5	0.1	0.0	-0.1
Worry too long after embarrassment	0.7	1.2	3.0	-0.1	-0.2	1.7	1.0	1.3
Number of children fathered	0.7	0.8	2.5	-0.9	-0.7	1.6	0.1	0.3
Average weekly red wine intake	0.7	1.0	3.4	-1.1	-0.3	1.8	-0.8	0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	1.2	0.2	0.5	1.5	0.3
Depression (Nagel 2018)	0.6	0.9	3.1	1.8	1.1	0.4	0.4	-0.1
Worry (Nagel 2018)	0.6	1.3	3.8	-1.0	-1.9	1.2	-0.2	-0.3
LDL Cholesterol	0.6	0.9	2.4	-0.7	-0.5	0.2	1.6	1.2
Lupus	0.6	0.9	2.0	-1.0	-0.8	-0.3	1.0	1.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	1.6	1.2	-1.0	0.7	0.1
Systolic blood pressure, automated reading	0.6	1.7	3.3	-1.8	-1.3	0.0	1.3	1.4
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.2	-1.2	0.6	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.0	-0.9	-1.7	1.1	0.5	0.8
Stomach or abdominal pain in last month	0.6	0.7	1.7	1.1	1.3	0.6	0.2	0.1
Body mass index (BMI)	0.6	2.7	6.0	0.8	0.5	-2.3	2.4	1.3
Alcohol usually taken with meals	0.6	1.0	2.9	-0.7	0.3	-0.2	1.2	1.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.0	1.0	0.7	-0.6	0.9	1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.8	-0.6	-1.9	0.2	0.3	0.2
Arm fat percentage (right)	0.6	2.3	4.9	0.9	1.0	-2.2	2.0	1.0
Trunk fat-free mass	0.6	3.7	10.4	0.9	0.1	-1.5	-2.2	-3.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.6	0.0	0.4	-0.5	1.0	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	6.5	0.0	0.4	-0.6	-2.5	-1.7
Trunk predicted mass	0.6	3.6	10.3	1.0	0.2	-1.5	-2.2	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	-0.0	-1.0	1.3	1.0	1.0
Birth weight of first child	0.6	1.0	2.2	-1.1	-1.5	-1.3	-0.3	-0.2
Comparative body size at age 10	0.6	1.7	3.5	1.2	1.9	-0.7	1.5	0.8
Wheeze or whistling in the chest in last year	0.6	1.0	1.7	0.9	1.3	0.9	1.3	0.3
Eye problems/disorders: None of the above	0.6	0.7	2.4	0.7	1.5	0.3	-0.7	0.2
Neck or shoulder pain in last month	0.6	0.9	2.2	0.2	0.2	1.0	-1.1	-1.5
Medication: Omeprazole	0.6	0.7	1.9	0.9	0.3	0.2	-0.7	-1.4
Family relationship satisfaction	0.6	0.7	1.2	1.1	0.9	-0.9	-0.5	-0.7
Hypertension (Self-reported)	0.6	1.7	4.1	-0.4	-0.2	-0.8	2.0	1.8
Arm fat percentage (left)	0.6	2.2	5.2	0.5	0.6	-2.3	2.0	1.1
Back pain experienced in last month	0.6	0.9	2.6	1.0	0.7	1.6	0.4	0.3
Guilty feelings	0.6	0.9	1.7	1.3	1.2	1.0	-0.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.9	0.2	-0.3	0.2	-0.8	-1.7
Pack years of smoking	0.6	0.9	3.6	-0.7	-0.3	-1.9	-0.4	-0.0
Crohns Disease (2012)	0.5	0.8	1.5	-1.2	-1.2	-0.5	0.7	0.6
HDL Cholesterol	0.5	0.8	2.4	-0.7	-0.6	0.3	-1.6	-0.7
Neuroticism (2016)	0.5	0.7	1.5	1.2	1.1	0.4	-0.9	-0.3
Heel T-Score	0.5	4.2	6.5	-2.1	-2.0	-0.8	2.5	2.4
Systolic Blood Pressure	0.5	2.6	3.5	-1.8	-1.4	1.3	1.6	1.9
Medication for hormone replacement therapy	0.5	0.5	1.3	0.1	0.4	1.1	-0.1	-1.1
Medication: Metformin	0.5	0.6	1.8	0.6	-0.1	-1.4	1.0	-0.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	0.5	1.2	0.8	-0.2	-0.4
High blood pressure	0.5	1.4	3.5	-0.6	-0.3	-0.5	1.9	1.6
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-1.3	-1.4	0.3	0.4	0.0
Qualifications: None of the above	0.5	1.0	2.0	1.4	0.4	0.1	-0.9	-1.4
Pain all over the body in last month	0.5	0.5	1.4	-1.2	-0.6	0.4	0.2	0.9
Fluid intelligence score	0.5	1.0	1.5	-1.1	-0.9	1.2	-1.0	-0.5
Worrier / anxious feelings	0.5	0.9	2.8	1.2	0.4	1.7	-0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-0.2	0.1	0.6	1.6	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	2.8	0.3	0.3	0.6	0.7	1.7
Noisy workplace	0.5	0.7	1.4	0.3	-1.2	-0.9	1.0	-0.3
Depression (self-reported)	0.5	0.6	2.2	0.0	-0.7	-1.5	-0.5	-0.5
Illnesses of mother	0.5	0.7	2.1	0.7	0.2	1.4	-0.5	-0.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.2	-0.7	0.1	-1.5	0.1	-0.3
Headache pain in last month	0.5	0.9	1.8	0.4	1.3	1.1	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.7	2.4	0.7	1.0	1.5	-0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	0.8	0.2	1.1	-0.6	-1.4
High blood pressure (siblings)	0.5	0.7	1.4	-0.3	-0.3	-0.9	1.2	1.0
Arm fat-free mass (right)	0.5	2.6	7.5	1.0	0.1	-1.5	-1.5	-2.7
Age at first live birth	0.5	0.9	1.8	0.2	0.6	-1.1	-1.1	-1.3
Pulse wave peak to peak time	0.5	0.6	2.1	0.8	0.1	1.5	-0.7	-0.2
Medication: Ibuprofen	0.5	0.7	2.0	-0.5	-0.4	-0.4	0.8	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.6	-0.0	0.6	1.1	1.0
Whole body fat-free mass	0.5	2.7	6.8	0.9	0.1	-1.9	-1.5	-2.6
Mood swings	0.5	0.9	3.2	1.2	1.8	0.2	0.0	0.0
Whole body water mass	0.5	2.6	6.4	1.0	0.2	-1.9	-1.4	-2.5
Medication: Bendroflumethiazide	0.5	0.7	1.7	-0.3	-0.0	-0.9	1.3	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.3	0.1	-0.5	1.1	-0.9	-0.6
Ever depressed for a whole week	0.5	0.6	1.7	0.0	-0.3	-0.8	1.3	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-1.3	-0.9	-0.2	-0.6	-0.0
Alzheimer’s Disease (in father)	0.4	0.4	1.0	-0.3	-1.0	0.5	0.4	0.6
Waist Hip Ratio (WHR)	0.4	1.8	3.6	-1.2	-1.5	0.6	1.9	1.1
Pack years adult smoking proportion	0.4	0.7	2.5	-0.7	-0.4	-1.6	-0.4	-0.1
Relative age voice broke	0.4	0.5	2.2	0.5	0.1	1.5	-0.1	0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.2	-0.5	0.0	1.1	0.8	0.7
Trunk fat mass	0.4	1.5	5.6	1.0	0.8	-2.4	0.2	-0.5
Waist circumference	0.4	1.4	4.6	0.5	0.2	-2.1	1.4	0.3
Heart attack	0.4	0.5	1.1	0.0	0.2	0.9	-1.1	-0.8
Neuroticism score	0.4	0.9	1.6	0.2	-0.5	1.3	1.2	1.1
Weight	0.4	2.0	6.1	1.3	0.8	-2.5	-0.3	-1.2
Hip circumference	0.4	1.8	4.2	1.3	1.3	-2.0	-0.3	-1.1
Number of live births	0.4	0.5	1.2	-0.0	0.3	-0.9	1.1	0.8
Pulse rate	0.4	0.6	1.3	1.2	0.6	-0.8	0.3	-0.8
Arm fat mass (right)	0.4	1.6	4.8	1.1	0.8	-2.2	1.2	0.0
Tense / ‘highly strung’	0.4	0.6	1.2	-0.0	-1.0	1.1	0.7	0.6
Medication: Paracetamol	0.4	0.6	1.5	1.2	1.0	0.5	0.4	0.5
Body fat percentage	0.4	1.7	4.2	0.8	0.9	-2.0	1.5	0.8
Leg fat percentage (right)	0.4	1.3	2.2	0.7	1.1	-1.4	1.5	0.7
Whole body fat mass	0.4	1.6	5.6	1.0	0.7	-2.4	0.9	-0.0
Leg fat mass (right)	0.4	1.6	4.5	1.1	1.1	-2.1	1.1	0.0
Arm predicted mass (right)	0.4	2.0	5.7	0.9	0.0	-1.3	-1.2	-2.4
Chest pain or discomfort	0.4	0.6	1.1	0.5	0.8	0.8	-0.3	-1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	0.1	1.3	0.4	0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	0.0	-0.2	0.2	-1.2	-1.0
Supplements: Vitamin C	0.4	0.5	0.9	-0.1	-0.6	0.7	0.7	0.9
Osteoporosis (self-reported)	0.4	0.5	1.1	0.4	1.0	0.9	0.2	0.6
Medication: Aspirin	0.4	0.5	0.9	-0.8	-0.8	-0.9	0.0	-0.4
Arm fat mass (left)	0.4	1.5	4.4	0.8	0.6	-2.1	1.4	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.5	-0.1	0.1	0.5	1.3
Medication: Lisinopril	0.4	0.5	1.5	0.4	0.3	-1.2	0.7	0.3
Alcohol drinker status: Never	0.4	0.4	1.0	-0.2	0.0	-0.9	1.0	0.6
Basal metabolic rate	0.4	2.1	4.8	1.0	0.2	-1.9	-1.1	-2.2
Arm fat-free mass (left)	0.4	2.3	5.8	1.5	0.7	-1.3	-1.1	-2.4
Fractured/broken bones in last 5 years	0.4	0.6	1.0	0.6	1.0	-0.9	-0.6	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.3	-1.1	-0.5	0.6	-0.2	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.2	0.4	0.8	-1.1	-0.9
Leg fat mass (left)	0.4	1.5	4.7	1.1	1.0	-2.2	0.8	-0.3
Arm predicted mass (left)	0.4	2.0	5.2	1.3	0.4	-1.3	-1.1	-2.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.2	0.9	1.0	1.1	0.7	-0.3
Prostate Cancer	0.3	0.4	1.0	-1.0	-0.3	1.0	-0.0	0.1
Blood White Count	0.3	2.5	11.8	-0.3	0.3	-3.4	0.6	0.1
BMI	0.3	2.0	7.6	-0.3	-0.3	-2.7	1.4	0.1
Lung FEV1/FVC ratio	0.3	1.4	4.8	1.3	0.5	2.2	-0.3	-0.3
Impedance of leg (right)	0.3	1.5	4.2	-0.6	0.9	2.1	-1.4	-0.3
Trunk fat percentage	0.3	1.3	3.5	0.9	0.9	-1.9	1.0	0.5
Maternal smoking around birth	0.3	0.4	0.9	-1.0	-0.6	0.4	-0.3	-0.6
Impedance of leg (left)	0.3	1.5	4.1	-0.3	1.0	2.0	-1.5	-0.6
Leg predicted mass (left)	0.3	1.4	4.4	0.7	-0.2	-2.1	-0.3	-1.3
Number of incorrect matches in round	0.3	0.5	1.8	-1.3	0.1	0.3	0.3	0.8
Past tobacco smoking	0.3	0.5	1.3	0.8	1.2	-0.5	0.5	0.1
Financial difficulties in last 2 years	0.3	0.4	1.1	0.2	-0.1	0.8	-0.2	-1.1
Illnesses of siblings	0.3	0.5	1.1	-1.0	-0.6	0.2	-0.9	-0.3
Father’s age at death	0.3	0.4	1.3	-0.3	-0.3	-0.7	0.3	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.1	-0.7	-0.7	-0.8	-0.9
Asthma	0.3	0.7	2.0	0.3	1.4	-0.8	0.7	0.3
Length of working week for main job	0.3	0.4	0.7	-0.6	-0.1	-0.0	-0.8	-0.8
Peak expiratory flow (PEF)	0.3	0.7	1.7	0.4	0.7	1.3	-0.7	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.6	0.2	1.0	0.1	-0.6
Birth weight	0.3	0.6	2.6	0.0	0.5	-1.6	-0.6	-0.0
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.2	0.1	0.5	-0.7	-0.9
Medication: Blood pressure	0.3	0.6	2.1	-0.1	-0.7	-1.4	-0.4	-0.6
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.2	0.6	-0.9	-0.6	-0.4
Medication: Aspirin	0.3	0.4	0.7	-0.8	-0.8	-0.6	-0.2	-0.6
Knee pain experienced in last month	0.3	0.5	1.3	1.1	0.9	-0.0	-0.3	-0.7
Smoking status: Previous	0.3	0.4	1.3	-0.8	-1.1	0.0	-0.2	0.5
Leg fat-free mass (right)	0.3	1.4	3.9	0.7	-0.2	-2.0	-0.4	-1.4
Qualifications: nursing, teaching	0.3	0.5	1.2	0.2	0.4	1.0	-1.1	-0.2
Commuting to job workplace: Walk	0.3	0.4	1.0	1.0	0.2	-0.1	-0.8	-0.2
Asthma (self-reported)	0.3	0.6	1.9	0.1	1.4	-0.6	0.6	0.3
Osteoarthritis (self-reported)	0.3	0.3	1.1	-0.5	-1.0	0.2	0.5	0.4
Leg predicted mass (right)	0.3	1.4	4.1	0.7	-0.2	-2.0	-0.4	-1.4
Mother’s age at death	0.3	0.4	0.9	0.2	0.6	-0.6	-1.0	0.7
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-0.4	-0.5	-0.2	0.4	1.0
Leg fat percentage (left)	0.3	1.3	2.7	0.8	1.0	-1.6	1.4	0.5
Irritability	0.3	0.5	2.2	-0.1	-0.3	-1.5	-0.0	0.0
Myopia	0.3	0.5	0.8	0.9	0.6	-0.7	-0.2	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.8	0.6	0.0	0.6	-1.3	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.5	-1.2	-0.7	0.6	-1.0	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	2.0	0.2	-0.2	1.4	0.1	-0.3
Age at First Birth	0.2	0.3	0.8	0.1	0.9	0.1	-0.7	0.1
Blood Platelet Count	0.2	2.1	5.0	0.8	0.7	-1.1	1.8	2.2
Hypothyroidism (self reported)	0.2	0.5	1.4	0.3	-0.7	0.6	-0.6	-1.2
Neuroticism	0.2	0.5	1.9	-0.1	-0.7	1.4	-0.2	-0.3
Chronotype (morning person)	0.2	0.4	1.3	-0.4	0.7	-0.1	-0.2	1.2
Angina	0.2	0.2	0.4	0.5	0.6	0.0	-0.3	-0.5
Leg fat-free mass (left)	0.2	1.3	4.2	0.7	-0.1	-2.0	-0.3	-1.3
Taking other prescription medications	0.2	0.2	0.4	-0.5	-0.2	-0.6	-0.3	-0.7
Allergy	0.2	0.5	1.0	0.6	1.0	-0.9	0.4	0.3
Medication: Simvastatin	0.2	0.3	0.8	-0.7	0.1	0.9	0.5	-0.2
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.6	-0.2	-0.8	0.5	0.5
Medication: Lansoprazole	0.2	0.3	0.8	0.4	0.6	0.9	-0.0	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.6	0.1	-1.0	0.2	0.1
Qualifications: College or University degree	0.2	0.7	2.5	-0.9	-0.1	-1.6	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	0.1	0.3	0.4	-1.1	-0.7
Angina (self-reported)	0.2	0.2	0.8	0.3	0.3	0.1	-0.5	-0.9
Pulse rate, automated reading	0.2	0.7	1.9	0.2	-0.3	-0.5	1.4	1.0
Suffer from ‘nerves’	0.2	0.3	0.7	-0.6	-0.8	-0.2	0.7	0.2
Illnesses of father: Heart disease	0.2	0.3	0.6	0.5	0.6	-0.2	-0.0	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.0	-0.2	-0.5	-1.0	-0.1	0.2
Medication for cholesterol	0.2	0.3	0.8	0.2	-0.7	-0.9	-0.3	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.3	0.3	0.6	-0.7	-0.5
Medication: Paracetamol	0.2	0.3	0.8	0.3	0.3	0.4	0.7	0.9
Medication: Atorvastatin	0.2	0.3	0.5	-0.2	-0.6	-0.7	0.7	0.2
Ever smoked	0.2	0.4	0.8	-0.9	-0.8	0.4	-0.4	-0.1
Number of operations (self-reported)	0.2	0.4	1.3	0.6	-0.2	-1.1	0.2	-0.2
Risk taking	0.2	0.3	0.6	-0.5	-0.2	-0.4	0.8	0.7
Pain experienced in last month	0.2	0.4	1.1	-1.0	-0.7	-0.3	-0.3	-0.4
Impedance of whole body	0.2	1.1	2.7	-0.4	0.8	1.6	-1.4	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.6	-0.6	-0.6	-0.4	-0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.5	0.1	-0.0	-0.5	-0.1	-0.7
Rheumatoid Arthritis	0.1	0.2	0.4	0.4	0.0	0.4	0.4	0.6
Blood Eosinophil Count	0.1	0.7	2.3	-0.3	-1.5	-1.0	-0.1	0.4
Respiratory disease	0.1	0.3	1.3	0.4	1.1	-0.4	-0.1	-0.1
Lung FVC	0.1	0.5	1.3	-0.7	0.3	-0.0	-0.6	1.2
Average weekly spirits intake	0.1	0.2	0.4	-0.6	0.2	0.4	-0.1	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.0	-0.1	0.2	0.5	-0.3
Impedance of arm (right)	0.1	0.4	0.6	-0.1	0.7	0.6	-0.8	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.7	-0.3	0.0	0.1	0.6
Impedance of arm (left)	0.1	0.5	1.1	-0.8	0.2	0.8	-1.1	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.3	0.1	-0.3	-0.5	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.4	0.2	-0.5	0.1	0.1	-0.7
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	0.3	0.0	-0.3	0.5
Overall health rating	0.1	0.3	0.6	0.6	0.8	-0.5	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.3	0.3	-0.0	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.2	0.1	0.7	-0.6	-0.3
Medication: Blood pressure	0.1	0.2	0.5	0.4	0.7	-0.2	0.6	0.0
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.0	-0.2	-0.1	0.5	0.6
Age started oral contraceptive pill	0.1	0.2	0.6	0.2	-0.2	0.8	0.3	0.4
Cholesterol lowering medication	0.1	0.1	0.3	-0.5	-0.0	-0.0	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	-0.0	-0.7	0.3	0.1	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	-0.2	0.5	-0.1	-0.5
Hair Pigment	0.0	1.4	1.8	-1.1	-1.0	-1.4	-1.2	-1.2
Tanning	0.0	0.3	0.6	-0.1	-0.8	0.3	-0.7	-0.8
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.1	0.2	0.1	-0.2	-0.2

Hub : Genes

SCARA3

Models

Trait associations