Hub : Genes

SCARB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1432	0.0406	6.3e-04	0.049	NA	0.054	NA	0.055	1.2e-05	NA	5.5e-06	NA	4.0e-06
2	GTEx	Pancreas	0.2620	0.0820	4.9e-03	0.000	NA	-0.001	NA	0.000	3.3e-01	NA	3.4e-01	NA	3.2e-01
3	GTEx	Testis	0.3130	0.1040	7.7e-03	0.051	NA	0.124	NA	0.147	2.7e-03	NA	4.1e-06	NA	4.8e-07
4	METSIM	Adipose	0.0945	0.0290	1.1e-04	0.018	0.025	0.039	0.035	0.035	9.7e-04	9.3e-05	1.6e-06	5.0e-06	5.2e-06
5	YFS	Blood	0.1646	0.0240	0.0e+00	0.084	0.100	0.131	0.096	0.123	5.1e-26	4.7e-31	1.9e-40	8.8e-30	4.5e-38
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1313	0.0339	1.6e-09	0.120	0.091	0.097	NA	0.109	2.3e-13	1.9e-10	4.7e-11	NA	3.0e-12
7	TCGA	Thyroid Carcinoma	0.0790	0.0280	4.4e-05	-0.003	0.037	0.003	NA	-0.003	1.0e+00	1.5e-04	1.4e-01	NA	8.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.7	2.6	5.7	2.2	1.1	1.4	0.8	1.4	-2.4	1.5
Bipolar Disorder or Schizophrenia	0.5	1.2	2.7	1.6	0.6	1.6	-0.2	1.2	-1.0	-0.7
Depressed Affect (Nagel 2018)	0.5	1.1	1.9	1.4	0.5	0.9	-0.5	-1.3	-1.2	1.1
Depression (Nagel 2018)	0.4	0.6	3.1	0.8	-0.1	0.5	-1.8	-0.5	-0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.7	0.1	0.1	-0.1	0.8	-0.2	-0.4	0.2
Neuroticism (Nagel 2018)	0.5	1.2	3.3	0.5	0.6	-0.3	-0.1	-1.8	-1.1	1.7
Schizophrenia (2018)	0.4	0.8	3.5	0.2	-0.1	1.0	-0.5	0.7	0.6	-1.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	-0.8	-1.4	0.6	-1.0	-1.1	0.5	-0.1
Worry (Nagel 2018)	0.6	1.2	4.5	-0.6	-0.5	-1.6	-0.1	-2.1	-0.2	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	2.5	0.0	0.7	0.9	-0.0	-0.6	0.4	1.6
Alzheimer’s Disease (in father)	0.9	1.0	3.5	0.7	1.9	0.5	-0.7	1.2	0.3	0.8
Alzheimer’s Disease (including proxy)	1.8	2.6	6.9	1.6	2.6	2.1	-0.1	0.5	-0.8	1.9
Crohns Disease (2017)	0.5	1.2	4.0	-0.4	-2.0	-0.0	-0.8	-1.6	-0.4	-0.9
Irritable Bowel Disease (IBD)	0.4	1.0	3.1	-0.3	-1.4	0.1	-1.2	-1.8	-0.5	-0.4
Ulcerative Colitis (UC)	0.3	0.6	2.2	-0.4	-0.2	0.2	-1.5	-1.2	0.1	-0.0
Major Depression (MDD)	0.8	1.0	2.4	0.8	0.6	1.0	0.9	0.7	-1.1	1.6
Reaction Time	1.1	2.0	4.8	-1.1	-1.9	-0.3	-0.8	-1.1	1.6	-2.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.3	0.2	0.0	1.1	0.8	-0.2	-0.2	1.8
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.6	0.8	2.4	-0.6	-1.5	0.0	-0.8	-0.8	0.6	-1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.4	4.7	-1.2	-0.4	-1.1	0.8	-2.2	0.9	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.3	-1.0	-0.1	-0.5	0.9	-0.2	1.1	-1.1
Coronary Artery Disease (CAD)	2.9	3.5	8.4	-2.7	-1.8	-2.9	0.6	-1.6	1.4	-0.8
Crohns Disease (2012)	0.3	0.5	2.3	0.0	-1.5	0.9	0.2	-0.5	-0.4	0.0
Mean Putamen Volume	0.5	0.6	2.7	0.1	0.7	0.4	-0.0	0.5	0.9	1.6
Fasting Glucose	0.8	0.9	3.5	1.2	1.9	0.5	0.1	0.4	-0.9	-0.5
HbA1C	0.8	0.9	2.4	-0.8	1.5	-1.2	0.2	-0.6	0.3	-1.1
HDL Cholesterol	7.2	11.9	25.7	4.0	3.0	4.6	-5.1	-0.3	0.8	3.3
LDL Cholesterol	0.7	1.1	7.2	0.3	2.7	-0.2	0.4	-0.0	-0.4	-0.0
Lupus	0.3	0.5	2.5	-0.3	-0.8	0.2	0.2	-1.6	0.5	-0.1
Neuroticism (2016)	3.7	5.3	9.9	2.8	2.3	1.9	0.6	1.1	-3.0	3.1
Primary Biliary Cirrhosis	1.1	1.6	4.7	-0.3	-0.2	-0.5	-1.8	-1.4	1.0	2.2
Rheumatoid Arthritis	0.3	0.5	2.3	-0.2	1.5	0.2	-0.4	0.3	0.5	-0.6
Schizophrenia (2014)	0.3	0.6	2.2	0.8	-0.2	1.5	-0.2	1.1	-0.1	-0.2
Triglycerides	1.0	1.6	5.8	0.4	1.3	0.4	2.4	0.5	-1.0	1.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.9	0.4	0.6	0.1	1.9	0.9	-0.4	2.2
Ulcerative Colitis	0.1	0.1	0.3	-0.2	-0.6	0.2	-0.1	-0.3	0.2	-0.1
Blood Eosinophil Count	0.2	1.5	5.2	0.4	1.5	-0.2	2.3	1.6	-0.1	0.6
Blood Platelet Count	0.5	5.8	11.8	2.9	3.3	2.5	-0.9	1.6	-0.3	3.4
Blood Red Count	0.5	5.0	12.4	-2.5	-2.1	-3.5	-0.6	-1.9	0.5	-2.7
Blood White Count	0.7	5.0	11.4	3.3	1.0	3.4	0.5	1.6	-1.8	2.3
Heel T-Score	0.4	3.5	15.7	-1.4	4.0	-2.2	0.4	0.6	1.3	-0.3
BMI	0.2	1.2	4.0	1.1	0.2	0.6	0.4	2.0	-1.5	-0.2
Height	0.1	1.2	3.0	1.2	-1.7	-0.3	0.8	-0.2	-0.6	-1.7
Waist Hip Ratio (WHR)	2.7	11.9	22.6	-4.1	-4.8	-4.2	1.2	-3.2	2.5	-2.8
Systolic Blood Pressure	0.4	1.8	4.8	-2.2	-1.6	-1.6	0.6	-0.4	-0.4	1.4
Smoking Status	0.8	2.0	10.0	-0.8	-3.2	-0.4	0.7	-0.8	0.3	-1.5
Allergy or Eczema	0.9	2.4	6.7	-1.8	-0.7	-2.6	0.9	-1.5	0.9	-1.6
Cardiovascular Disease	1.5	4.9	14.2	-3.8	-1.5	-3.5	0.5	-1.9	1.2	-0.6
Hypothyroidism (self reported)	0.3	0.6	1.7	0.6	1.3	1.3	-0.2	0.5	0.1	-0.1
Respiratory disease	0.3	0.6	1.2	-1.1	-0.4	-0.6	1.1	-0.6	0.5	-0.8
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.2	-2.3	-2.0	-1.5	0.1	-0.7	1.5	-1.6
Lung FEV1/FVC ratio	0.6	2.9	7.8	-1.1	-2.5	0.4	-2.8	-0.2	1.6	-1.7
Lung FVC	0.5	2.4	10.8	-1.4	0.8	-1.3	1.5	-0.1	0.1	-3.3
Neuroticism	0.3	0.8	2.5	0.4	0.5	-0.2	-0.3	-1.5	-0.7	1.6
Chronotype (morning person)	0.5	1.1	4.1	0.5	-0.3	0.4	0.9	1.4	-0.2	2.0
Hair Pigment	0.0	0.9	3.2	0.8	-0.2	0.9	-0.8	-0.9	0.4	1.8
Tanning	0.1	1.5	3.8	-0.7	-0.9	-2.0	-1.1	1.4	0.4	1.4
Hand grip strength (left)	0.3	0.9	3.2	0.5	0.9	0.9	-1.8	-0.7	-0.2	-0.7
Number of treatments/medications taken	1.0	1.8	4.1	-2.0	-0.7	-1.8	1.5	-0.5	1.5	0.2
Average weekly spirits intake	0.3	0.4	1.7	0.0	0.3	0.2	-0.7	0.6	0.6	-1.3
Sensitivity / hurt feelings	1.0	1.7	7.4	0.9	1.8	-0.1	0.2	0.6	-0.5	2.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.7	0.3	-0.3	-0.8	-0.7	-0.9	0.1
Hearing difficulty/problems: Yes	0.7	1.0	3.1	0.3	-0.0	1.2	1.4	0.6	0.2	1.8
Relative age of first facial hair	1.4	2.9	10.6	1.5	3.2	0.8	1.5	1.8	-0.4	1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	6.1	0.2	0.2	0.1	2.5	1.0	-0.2	1.9
Ever used hormone-replacement therapy (HRT)	6.6	8.4	16.0	4.0	0.4	3.4	0.9	3.7	-2.5	3.2
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	0.3	1.0	-0.1	0.5	0.4	-0.6	0.3
Systolic blood pressure, automated reading	0.6	1.8	3.4	-1.8	-1.4	-1.7	1.3	0.6	0.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	-0.9	-0.7	-1.2	-0.9	-1.0	0.7	-1.4
Angina	1.7	2.3	5.3	-1.9	-0.4	-2.3	1.2	1.5	0.6	-1.6
Medication for hormone replacement therapy	1.2	1.4	2.9	1.1	-0.6	0.3	1.7	1.3	-0.8	1.7
Vitamin and mineral supplements	0.3	0.5	1.3	-0.9	0.6	-0.3	-0.6	-0.2	-0.5	-1.2
Supplements: Zinc	0.8	0.8	3.3	-0.6	-0.9	-0.3	-0.1	-1.1	-0.1	1.8
Medication: Co-codamol	0.7	0.9	2.0	0.5	0.5	0.7	1.2	1.0	-1.4	0.7
Medication: Metformin	1.0	1.4	3.5	-1.6	-0.8	-1.9	0.6	-0.4	1.5	-0.6
Diabetes (father)	0.2	0.2	0.5	0.2	0.3	0.7	0.5	-0.5	-0.6	-0.0
Diabetes (mother)	0.9	1.2	3.0	-0.9	-0.5	-0.3	-1.1	-1.7	1.4	-1.0
Severe depression (siblings)	0.9	1.0	4.2	-0.0	0.9	0.8	-2.0	-0.4	1.1	0.3
Pack years adult smoking proportion	0.6	1.0	3.1	0.1	-1.4	0.7	-1.0	0.3	-0.4	1.8
Impedance of leg (right)	0.4	1.8	6.0	2.4	0.9	1.9	-0.3	1.1	-0.8	0.6
Leg fat-free mass (left)	0.2	0.9	4.3	-0.6	-0.7	-0.5	0.5	-0.2	-0.6	-2.1
Trunk fat percentage	0.8	3.1	7.0	2.5	1.5	1.3	1.6	2.6	-1.5	0.3
Hand grip strength (right)	0.5	1.4	4.8	-0.5	-0.9	-0.2	-2.2	-1.9	0.4	-0.3
Townsend deprivation index at recruitment	1.6	2.3	5.0	-2.2	-2.2	-1.1	0.6	0.2	1.9	-0.7
Current tobacco smoking	0.5	0.8	2.7	-0.7	-1.6	-0.2	-0.9	-1.1	-0.1	-0.3
Average weekly fortified wine intake	0.5	0.6	1.3	0.1	-0.7	-0.1	-1.2	-1.1	-0.2	1.1
Maternal smoking around birth	0.8	1.2	3.7	0.5	1.3	0.3	-0.6	1.4	-0.4	1.9
Fed-up feelings	0.7	1.3	2.5	1.3	1.3	0.6	-1.6	-1.6	-0.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	0.5	-0.1	0.1	-1.1	0.1	0.0	-1.0
Relative age voice broke	0.5	0.7	2.6	0.6	1.6	-0.1	-0.2	1.3	-0.2	0.3
Taking other prescription medications	0.3	0.4	1.3	-0.2	1.1	-0.2	0.8	0.2	-0.1	-0.9
Age when periods started (menarche)	1.4	3.4	7.5	2.7	-0.0	0.4	1.3	2.7	-2.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	-0.4	0.4	-0.8	1.3	0.3	-0.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	8.0	-1.2	0.4	-2.8	0.2	0.2	-0.2	2.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.7	1.0	0.2	0.3	0.1	1.9	0.2	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.1	-0.6	-0.6	-0.4	0.3	-0.6	0.1
Serious illness, injury or assault to yourself	1.0	1.2	3.0	-1.6	-1.1	-1.2	1.7	0.4	0.2	-0.5
High blood pressure	0.5	1.4	3.8	-1.9	-0.2	-1.8	1.2	-0.7	0.4	1.0
Hayfever, allergic rhinitis or eczema	1.0	2.2	5.6	-1.3	-0.1	-2.2	0.3	-0.9	1.5	-2.4
Multivitamins +/- minerals	0.6	0.7	2.3	1.1	0.2	1.1	0.2	-0.3	0.4	1.5
Stomach or abdominal pain in last month	0.5	0.6	2.0	-0.1	0.3	-0.7	0.7	-0.9	0.7	1.4
Supplements: Glucosamine	0.7	0.9	4.4	0.6	0.2	0.6	-0.0	1.0	0.4	2.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-1.1	-1.4	-0.9	-0.0	-0.4	0.4	-0.7
Medication: Atenolol	0.9	1.1	2.1	-1.3	-1.2	-0.7	1.5	0.5	1.5	0.0
Medication: Levothyroxine sodium	0.4	0.7	3.5	-0.4	1.9	-0.0	0.8	0.1	0.6	0.7
Sitting height	0.0	0.4	0.9	0.6	0.3	0.7	-0.0	-0.7	-0.3	-1.0
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.1	0.0	-0.7	0.1	0.6	-0.9	0.4
High blood pressure (mother)	0.4	0.5	1.5	-0.7	0.1	-0.3	-0.7	-1.2	0.5	-1.0
Body mass index (BMI)	0.1	0.5	2.4	0.0	0.4	0.1	0.6	1.5	-0.4	-0.4
Impedance of leg (left)	0.4	2.0	6.5	2.5	0.8	1.9	0.0	1.3	-0.9	1.0
Leg predicted mass (left)	0.2	0.9	4.3	-0.6	-0.8	-0.5	0.5	-0.2	-0.6	-2.1
Trunk fat mass	0.5	2.2	5.3	2.0	1.0	1.0	1.5	2.3	-1.4	-0.2
Waist circumference	0.2	0.7	2.0	-0.1	-0.8	0.1	1.1	1.4	0.2	-1.2
Number of incorrect matches in round	0.7	1.2	4.2	-1.2	-1.5	0.2	-0.0	0.1	2.1	-0.4
Past tobacco smoking	1.0	1.7	10.0	-0.7	0.7	-0.6	-3.2	-0.9	0.3	0.0
Alcohol usually taken with meals	0.6	1.0	3.4	0.1	-0.1	-1.2	1.8	1.1	-0.1	0.9
Nervous feelings	0.4	0.7	2.3	-0.0	-0.5	-1.5	0.9	-0.9	-0.7	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.9	2.0	0.9	0.5	-0.3	0.3	-1.3	1.9
Hearing difficulty/problems with background noise	1.6	2.5	8.1	0.2	0.6	0.7	2.8	0.8	-0.2	2.9
Hair/balding pattern: Pattern 2	3.8	4.8	7.9	-2.8	-1.9	-1.6	-1.4	-2.8	2.5	-1.9
Had menopause	1.0	1.3	4.6	0.5	0.4	0.9	1.3	0.8	-0.9	2.1
Had other major operations	1.4	1.7	6.7	-0.2	1.2	-0.4	2.6	1.5	-0.4	-1.2
Forced vital capacity (FVC)	0.4	1.7	9.2	-0.5	-0.1	-1.0	-0.4	-1.1	0.1	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	6.7	-1.3	0.6	-2.6	0.3	-0.5	-0.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.9	-0.4	0.6	0.0	-0.9	-1.7	0.5	0.1
Qualifications: None of the above	0.3	0.6	1.7	-0.7	-1.3	-0.3	-0.7	0.2	0.8	-0.9
Financial difficulties in last 2 years	1.2	1.6	2.7	1.4	1.1	1.3	0.6	1.4	-1.2	1.6
Mouth/teeth dental problems	1.2	1.8	4.2	-1.7	-2.1	-0.8	-0.3	-1.8	1.3	-0.4
Heart attack	3.7	4.8	10.4	-2.8	-1.6	-3.2	0.6	-1.3	0.9	-3.1
Allergy	0.8	1.9	4.1	1.8	-0.0	2.0	-0.8	0.9	-1.6	1.4
Pain all over the body in last month	0.8	0.9	2.9	-1.4	-0.2	-0.6	0.4	-0.7	1.7	0.6
Diabetes (self-reported)	1.7	2.7	5.1	-2.3	-1.1	-1.6	0.8	-0.4	2.2	-1.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.9	-0.9	0.7	-1.2	-0.1	-2.0	0.6	-0.6
Medication: Ramipril	1.7	2.2	5.8	-1.5	-1.4	-1.0	2.4	0.3	0.4	-2.0
Medication: Simvastatin	0.8	1.2	3.6	-1.9	-0.2	-1.3	1.1	0.3	1.2	0.4
Fluid intelligence score	0.2	0.4	1.6	0.1	-0.1	0.2	1.3	-0.8	-0.5	-0.3
Illnesses of siblings	0.6	0.8	3.1	0.9	0.0	1.8	0.2	0.5	0.2	-1.2
Neuroticism score	0.5	1.1	3.2	0.9	1.3	0.1	0.1	-0.9	-0.9	1.8
Weight	0.1	0.6	1.8	0.6	-0.0	0.3	0.8	1.4	-0.7	-1.0
Impedance of arm (right)	0.6	2.9	7.9	2.8	1.6	1.9	1.6	1.0	-0.6	1.5
Arm fat percentage (right)	0.5	2.1	4.8	1.7	1.2	1.2	1.5	2.2	-1.2	0.4
Trunk fat-free mass	0.2	1.3	4.6	-1.0	-1.6	-0.7	-0.4	-0.6	-0.1	-2.1
Hip circumference	0.9	4.1	9.8	2.6	1.4	2.6	0.6	3.1	-1.7	0.5
Time employed in main current job	0.5	0.6	3.4	0.4	1.9	0.3	-0.8	0.0	-0.2	-0.3
Alcohol intake versus 10 years previously	1.0	1.5	3.5	1.0	0.5	0.6	1.9	1.6	-1.0	1.3
Father’s age at death	7.4	9.9	18.5	3.7	1.9	2.5	2.3	3.8	-2.7	4.3
Worrier / anxious feelings	0.5	0.9	2.1	0.0	0.2	-0.9	1.5	1.0	0.6	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.4	0.8	-0.4	-0.9	-0.1	-0.3	1.0
Falls in the last year	0.1	0.2	1.0	0.1	-0.3	-0.2	0.0	0.1	-0.2	1.0
Hair/balding pattern: Pattern 3	0.5	0.8	2.4	1.1	-0.3	0.5	-0.7	1.5	-1.0	0.5
Number of live births	1.3	1.9	7.7	1.3	2.8	1.0	0.4	1.2	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	9.1	-1.0	-0.0	-1.2	-0.8	-1.3	0.6	-3.0
Pulse rate	1.3	2.2	3.9	-1.6	-1.4	-2.0	0.2	-1.7	0.6	-1.9
Happiness	0.2	0.3	0.7	0.1	-0.3	0.4	0.6	-0.7	-0.1	-0.9
Noisy workplace	0.5	0.6	2.4	-1.0	0.6	-1.6	-0.5	-0.5	-0.1	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	5.5	-0.3	0.9	0.5	1.2	-2.3	0.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	7.4	0.9	-1.1	1.0	-2.7	0.3	-0.6	-2.3
Mouth/teeth dental problems: Dentures	0.8	1.4	3.1	1.2	1.6	0.8	0.5	1.8	-1.2	0.7
Asthma	0.1	0.2	0.6	-0.4	-0.8	0.5	0.2	-0.1	0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.5	1.6	0.9	1.0	-0.2	1.9	-0.1	0.9
Medication: Cholesterol lowering	1.6	2.5	9.1	-2.5	0.1	-3.0	0.6	-0.1	1.3	-0.5
Depression (self-reported)	0.7	0.8	1.6	0.4	-1.0	1.2	-1.3	-0.2	-0.4	-1.2
Medication: Lansoprazole	0.2	0.2	0.4	0.6	-0.0	0.6	0.4	-0.3	-0.1	0.6
Prospective memory result	0.3	0.4	1.2	-0.3	-1.1	-0.5	-0.5	0.3	0.9	-0.1
Lung cancer (father)	0.7	0.9	2.1	1.3	-0.4	0.1	-0.2	0.8	-1.2	-1.5
Illnesses of mother	0.8	1.0	3.0	1.4	0.6	1.0	0.7	1.7	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	12.9	-0.9	-0.3	-0.3	-1.0	-1.4	0.7	-3.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.6	1.0	0.7	0.5	0.4	-0.6	0.5
Impedance of arm (left)	0.4	2.0	7.0	2.6	1.0	1.7	0.9	0.8	-0.5	1.1
Arm fat mass (right)	0.3	1.2	3.3	1.2	0.7	0.6	1.3	1.8	-1.1	-0.2
Trunk predicted mass	0.2	1.3	4.7	-1.0	-1.6	-0.6	-0.4	-0.6	-0.0	-2.2
Standing height	0.1	0.8	1.8	1.3	-1.0	0.1	0.8	-0.2	-0.8	-1.3
Length of working week for main job	0.5	0.6	1.2	-0.1	0.5	1.0	-0.3	0.8	0.9	-1.1
Exposure to tobacco smoke at home	0.4	0.4	1.5	0.4	1.2	-0.7	-0.5	-0.3	-0.6	0.5
Breastfed as a baby	0.7	0.8	2.9	0.9	0.6	0.8	1.7	0.9	-0.2	0.5
Tense / ‘highly strung’	0.3	0.4	1.0	-1.0	-0.7	-0.8	0.7	-0.6	0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	-0.0	-1.2	-1.2	0.1	-0.7	-0.3	-0.9
Hair/balding pattern: Pattern 4	1.1	2.6	7.8	1.0	2.2	0.6	1.8	0.8	-0.7	2.8
Birth weight of first child	2.3	4.2	10.1	-2.1	-1.8	-2.5	0.1	-2.1	1.0	-3.2
Peak expiratory flow (PEF)	0.3	0.6	2.9	-0.2	0.7	-0.9	0.5	-0.0	0.3	-1.7
Pulse wave reflection index	1.2	1.4	2.8	1.2	1.1	1.2	-0.9	1.4	-0.6	1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	0.3	0.4	-0.3	-1.0	-0.4	-0.4	0.9
Loud music exposure frequency	1.9	2.1	3.8	-1.6	-0.4	-1.1	-1.9	-1.9	1.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.3	-0.3	1.1	0.2	-1.3	-0.7	0.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	7.1	1.8	2.7	1.4	1.1	1.4	-1.1	0.5
Blood clot in the leg (DVT)	0.4	0.5	2.7	-0.5	0.4	-1.6	0.3	0.4	-0.1	-0.2
Medication: Paracetamol	0.1	0.2	0.5	-0.0	-0.4	-0.6	-0.1	0.1	0.5	0.7
Headache pain in last month	0.2	0.3	0.8	0.1	0.1	0.0	-0.5	0.9	0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	1.8	3.1	11.0	2.7	0.6	3.3	-1.2	0.9	-0.9	0.0
Glaucoma (self-reported)	0.6	0.7	3.0	-0.6	-0.1	-1.0	0.4	-0.1	-0.3	-1.7
Gout (self-reported)	1.1	1.5	6.8	0.6	1.4	-0.4	-0.6	-0.5	-0.7	-2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	-0.6	1.2	-0.6	0.9	0.4	0.4	-0.3
Medication: Amlodipine	0.9	1.3	3.6	-1.9	-0.2	-1.2	0.9	-1.7	0.5	-0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.6	6.6	1.2	1.7	2.6	-0.6	0.5	0.1	-0.3
Birth weight	1.0	2.2	5.7	-1.6	-1.6	-0.8	-0.6	-1.7	1.1	-2.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	0.1	0.8	0.2	-1.1	0.9	0.3	0.8
High blood pressure (siblings)	0.6	0.9	3.6	-0.8	-0.8	-1.9	-0.0	-0.6	-0.5	0.7
Forced vital capacity (FVC), Best measure	0.8	2.8	15.8	-0.5	0.1	-0.2	-0.9	-1.5	0.4	-4.0
Body fat percentage	0.8	3.1	7.7	2.2	1.4	1.5	1.5	2.8	-1.6	0.2
Leg fat percentage (right)	0.8	3.0	9.1	1.8	1.4	1.8	1.3	3.0	-1.2	0.2
Arm fat-free mass (right)	0.3	1.3	6.2	-0.7	-1.2	-0.5	-0.5	-0.4	-0.5	-2.5
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-0.2	-0.7	-1.1	-0.8	0.3	0.5	-0.1
Comparative body size at age 10	0.9	2.6	5.4	-2.0	-2.3	-1.6	-0.4	-1.1	1.2	-1.8
Number of full brothers	0.3	0.3	1.6	-0.1	1.3	0.2	0.1	0.5	0.6	-0.3
Worry too long after embarrassment	0.9	1.5	5.9	1.0	2.4	-0.1	1.2	0.2	-0.8	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.3	-0.9	-0.1	-0.8	-0.4	0.7	0.9
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	0.9	0.8	1.2	1.5	0.3	-1.4	-0.2
Number of children fathered	0.6	0.7	1.3	-0.7	-0.9	-0.3	-0.6	-1.1	0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.6	0.3	1.4	-0.1	2.1	0.6	-0.1	-0.0
Age at first live birth	0.6	1.0	4.6	-0.4	-0.8	-0.6	0.8	-2.1	-0.1	0.8
Pulse wave peak to peak time	0.2	0.2	0.6	-0.3	-0.8	-0.4	-0.4	-0.4	0.3	-0.6
Health satisfaction	0.2	0.2	0.7	-0.3	-0.0	0.1	0.1	-0.5	0.8	0.8
Shortness of breath walking on level ground	0.9	1.1	4.3	0.6	0.6	-0.3	2.1	0.9	0.4	1.2
Qualifications: College or University degree	0.3	1.0	2.6	0.1	1.3	1.6	0.1	-0.7	-0.4	-1.5
Eye problems/disorders: None of the above	0.5	0.6	1.4	0.9	-0.1	0.9	-0.5	-0.2	-0.8	1.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.1	-0.5	0.0	-0.1	0.3	0.6	0.3
Emphysema/chronic bronchitis	0.4	0.5	1.2	-0.8	-0.4	-0.8	-1.1	-0.7	0.0	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	1.7	0.2	0.0	1.2	-0.8	-1.3	-0.5	-0.7
Neck or shoulder pain in last month	1.4	2.0	5.1	-1.7	1.1	-2.0	0.7	0.8	2.3	0.1
Medication: Blood pressure	2.8	5.0	12.5	-3.4	-1.4	-3.5	0.9	-1.9	2.1	-0.3
Angina (self-reported)	1.9	2.5	6.1	-2.1	-0.8	-2.5	1.4	1.5	0.6	-1.6
Migraine (self-reported)	0.2	0.3	0.7	-0.2	-0.2	-0.9	0.6	-0.1	-0.7	0.6
Medication: Ibuprofen	0.4	0.5	1.3	1.1	0.2	0.7	-0.7	1.2	0.1	0.2
Medication: Allopurinol	1.4	1.8	7.5	0.6	1.7	-0.4	-0.6	-0.5	-1.1	-2.7
Medication: Omeprazole	1.1	1.3	3.2	-1.3	-0.7	-1.8	1.2	0.1	0.8	-1.3
Medication: Seretide 50 evohaler	0.4	0.4	1.1	0.9	0.2	1.1	-0.5	0.8	-0.1	0.2
Mean time to correctly identify matches	0.7	1.3	4.6	-1.0	-2.1	-0.1	-0.7	-0.4	1.6	-0.8
Heart disease (mother)	0.3	0.4	0.9	-0.1	-0.8	-0.6	-0.4	-0.7	-1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.2	5.0	10.5	3.2	1.9	2.1	0.8	2.8	-2.3	1.7
Whole body fat mass	0.5	1.9	5.3	1.5	0.7	0.9	1.5	2.3	-1.2	-0.6
Leg fat mass (right)	0.4	1.5	5.2	1.0	0.5	1.0	1.1	2.3	-1.0	-0.8
Arm predicted mass (right)	0.3	1.5	7.1	-0.8	-1.3	-0.4	-0.6	-0.5	-0.7	-2.7
Pulse rate, automated reading	0.5	1.7	5.3	-1.0	-1.4	-1.6	0.3	-0.7	-0.4	-2.3
Alcohol intake frequency.	0.7	1.5	3.4	-1.5	-1.5	-0.7	-1.4	-0.4	1.8	-0.5
Comparative height size at age 10	0.1	0.6	2.0	0.5	-0.5	0.1	-1.1	-0.4	-0.8	-1.4
Number of full sisters	0.1	0.2	0.5	-0.4	0.3	-0.7	-0.2	0.4	0.4	0.4
Suffer from ‘nerves’	0.3	0.5	0.9	-0.3	-0.8	-0.7	0.9	-0.8	-0.8	0.6
Overall health rating	0.4	0.9	2.7	-1.6	-0.1	-0.6	-0.2	-1.6	0.6	0.2
Chest pain or discomfort	0.9	1.3	5.6	-0.5	0.5	0.1	-0.1	-1.6	-0.5	-2.4
Had major operations	1.4	1.7	6.3	-1.2	-1.6	-2.5	-0.8	-0.9	0.0	-0.1
Age at last live birth	0.5	0.8	1.7	0.9	0.7	1.3	0.5	-0.6	-1.0	0.9
Family relationship satisfaction	0.6	0.8	3.0	-0.8	-0.7	-0.5	0.3	-1.7	0.9	0.1
Leg pain on walking	1.6	2.0	8.0	0.6	2.8	0.8	-1.0	1.7	1.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.1	-0.9	-1.5	-1.3	-1.4	-1.0	0.2	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	4.3	0.5	-2.1	0.4	-0.6	0.0	-0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	-1.3	0.0	-0.5	-0.4	-1.4	1.6	0.2
Medication: Aspirin	1.7	2.2	5.3	-2.3	-2.2	-1.8	1.0	-0.2	0.8	-0.3
Supplements: Vitamin C	0.4	0.5	1.5	0.2	-1.2	-0.8	0.8	-0.4	-0.4	-0.6
Knee pain experienced in last month	0.5	0.8	2.4	-1.6	0.3	-0.3	0.3	-0.2	1.5	0.8
Hypertension (Self-reported)	0.5	1.5	4.1	-2.0	-0.4	-1.6	1.1	-0.7	0.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	6.1	-0.7	-2.5	-2.1	1.6	-0.7	0.2	-2.2
Illnesses of father: Heart disease	2.0	2.8	7.5	-2.7	-1.9	-1.4	0.0	-2.3	0.4	-1.1
Illnesses of siblings: Diabetes	1.1	1.4	3.5	-1.7	0.3	-1.9	-0.1	-1.5	0.8	0.4
Smoking status: Previous	1.3	1.9	9.4	0.9	-0.5	0.8	3.1	1.2	0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.5	1.1	-0.3	1.6	-0.0	-1.1	-0.3	-1.9
Whole body fat-free mass	0.2	1.3	5.3	-1.0	-1.4	-0.7	-0.1	-0.5	-0.2	-2.3
Leg fat-free mass (right)	0.1	0.8	3.5	-0.7	-0.9	-0.7	0.4	-0.3	-0.4	-1.9
Arm fat percentage (left)	0.4	1.6	4.2	1.6	1.0	1.1	1.2	2.0	-1.1	0.0
Average weekly red wine intake	0.9	1.4	3.6	1.0	1.5	0.6	1.4	0.6	-1.9	-0.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.2	0.1	-1.5	0.8	-0.2	0.7	-0.9	0.8
Mood swings	1.3	2.4	6.6	1.7	-1.1	-0.5	1.3	-0.1	-2.1	2.6
Loneliness, isolation	0.4	0.5	1.6	0.3	1.3	0.7	-0.4	-0.3	-0.3	1.0
Long-standing illness, disability or infirmity	1.1	1.6	3.8	-1.9	0.4	-1.2	0.4	-1.1	1.9	-0.9
Ever had bowel cancer screening	2.2	2.6	9.5	0.4	1.8	-0.1	3.1	2.0	-0.8	0.7
Diabetes diagnosed by doctor	1.1	1.8	3.5	-1.9	-1.3	-1.1	0.2	-0.4	1.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.7	-0.9	0.5	-0.2	0.2	-0.5	1.3	0.0
Friendships satisfaction	0.7	0.9	2.2	0.1	-1.3	0.1	0.4	-1.5	-0.4	-1.4
Qualifications: nursing, teaching	0.7	1.0	2.8	1.3	0.4	0.5	1.0	0.0	-1.7	1.1
Commuting to job workplace: Walk	0.7	0.7	1.8	-1.4	0.5	-1.0	-0.1	-1.3	0.4	-0.4
Eye problems/disorders: Cataract	0.2	0.3	1.1	-0.5	-0.2	-0.3	1.0	0.2	0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	-0.2	0.2	-0.5	0.2	0.3	0.6	0.0
Medication for cholesterol	1.0	1.6	3.0	1.7	1.4	0.4	-1.6	0.6	-1.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.4	0.9	1.6	1.1	-1.3	-0.7	0.4	-0.1
Back pain experienced in last month	0.1	0.2	0.5	-0.1	0.7	-0.6	0.2	0.6	0.3	0.0
Mineral and other dietary supplements	2.1	2.8	14.6	0.7	1.3	1.0	-0.6	0.1	-1.2	-3.8
Breast cancer (self-reported)	0.6	0.7	3.1	0.3	0.3	0.3	1.8	0.5	-0.5	1.0
Asthma (self-reported)	0.3	0.6	1.7	-1.0	-1.3	-0.2	0.2	-0.6	1.0	-0.6
Osteoporosis (self-reported)	0.6	0.8	2.2	0.8	1.1	1.0	-0.6	1.5	-0.2	-0.2
Osteoarthritis (self-reported)	1.2	1.6	3.0	-0.3	1.5	1.3	-0.3	1.0	1.7	1.7
Medication: Aspirin	1.4	1.8	4.8	-2.2	-2.1	-1.3	1.0	0.1	0.7	-0.4
Medication: Gliclazide	0.7	0.8	1.9	-1.3	-0.9	-0.9	0.4	0.2	1.4	-0.0
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	0.7	0.1	0.5	-0.9	0.3	0.7	-0.3
Smoking status: Current	0.5	0.8	1.9	-0.8	-1.4	-0.2	-0.9	-1.1	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.8	-1.7	-0.7	-2.4	0.1	-0.7	0.8	-1.2
Whole body water mass	0.2	1.3	5.2	-0.9	-1.4	-0.7	-0.1	-0.5	-0.3	-2.3
Leg predicted mass (right)	0.2	0.9	3.8	-0.7	-0.8	-0.7	0.5	-0.3	-0.4	-1.9
Arm fat mass (left)	0.2	1.0	2.7	1.1	0.6	0.6	1.1	1.6	-1.0	-0.4
Number of self-reported non-cancer illnesses	2.1	3.6	9.9	-2.9	0.2	-3.2	1.8	-0.4	1.6	-0.9
Average weekly champagne plus white wine intake	0.7	0.9	2.7	0.9	1.6	-0.2	1.0	0.9	-1.0	-0.2
Miserableness	0.3	0.6	1.4	1.2	0.6	0.8	-0.3	-0.6	-0.7	-0.8
Guilty feelings	0.8	1.1	2.3	0.5	1.5	-0.5	-1.5	-0.7	-0.9	1.3
Wears glasses or contact lenses	1.4	1.6	4.2	1.4	0.2	2.0	1.0	1.7	-0.3	0.8
Ever taken oral contraceptive pill	1.7	1.9	4.6	2.0	-0.1	2.1	0.5	0.8	-1.1	1.6
Hearing aid user	0.3	0.4	1.1	-0.7	0.2	-1.1	0.2	-0.1	0.8	0.2
Mother’s age at death	0.3	0.4	2.4	0.4	-0.1	1.6	0.4	-0.1	0.2	-0.1
Financial situation satisfaction	0.4	0.4	1.4	0.3	-0.3	1.0	0.3	0.5	-0.3	1.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	5.8	0.3	2.4	0.5	0.8	0.3	-0.0	0.1
Commuting to job workplace: Public transport	0.8	1.0	3.4	0.6	1.8	0.8	-0.1	1.0	1.1	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	2.1	-0.5	0.2	-1.4	0.6	-0.3	-0.5	-1.4
Medication: Blood pressure	0.5	0.9	2.7	-1.6	-1.0	0.0	0.6	-0.2	1.4	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.8	0.1	1.7	-0.3	0.7	0.9	-0.1	-0.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	9.3	-0.6	-0.5	-0.6	0.5	0.7	1.7	3.1
High cholesterol (Self-reported)	1.9	3.4	11.2	-3.3	-0.5	-3.0	0.8	-0.3	1.7	0.1
Medication: Bendroflumethiazide	0.5	0.8	1.9	-1.1	-1.4	-0.2	-0.0	-0.5	1.1	0.7
Medication: Paracetamol	0.1	0.1	0.5	-0.1	-0.7	0.0	-0.4	0.1	0.5	0.3
Medication: Lisinopril	1.6	2.1	4.9	-1.7	-1.5	-1.5	-0.6	-2.2	1.1	0.8
Medication: Atorvastatin	2.0	2.5	5.3	-2.0	-0.2	-2.3	-0.9	-1.1	1.5	-2.1
Illnesses of father: High blood pressure	0.4	0.5	1.1	0.7	0.4	0.6	0.5	0.2	-1.0	1.0
Alcohol drinker status: Never	1.9	2.3	5.7	-1.1	-1.1	0.6	-1.3	-0.1	2.4	-2.4
Ever smoked	0.7	1.3	5.9	-0.3	-1.5	-0.0	2.4	-0.4	-0.6	-0.5
Basal metabolic rate	0.2	0.9	4.4	-0.5	-1.1	-0.4	0.0	-0.2	-0.4	-2.1
Leg fat percentage (left)	0.8	2.9	9.4	1.7	1.2	1.6	1.6	3.1	-1.2	0.5
Arm fat-free mass (left)	0.2	0.8	3.9	-0.6	-1.0	-0.3	-0.2	-0.1	-0.4	-2.0
Number of operations (self-reported)	0.9	1.4	4.1	-1.5	0.3	-2.0	1.0	0.5	0.9	-0.9
Average weekly beer plus cider intake	0.3	0.5	1.1	-1.1	-0.7	-0.9	0.4	-0.2	0.1	-0.8
Irritability	2.1	3.6	7.9	2.3	1.4	1.7	0.5	-0.0	-2.6	2.8
Risk taking	0.8	1.2	6.3	0.1	1.0	-0.4	0.5	2.5	-0.9	-0.3
Ever had prostate specific antigen (PSA) test	1.6	1.9	8.3	-0.2	0.2	-0.8	2.9	0.8	0.4	1.9
Fractured/broken bones in last 5 years	0.5	0.7	2.4	0.5	-1.6	0.3	-1.1	0.9	-0.1	-0.2
Age started oral contraceptive pill	0.1	0.2	1.1	0.2	1.0	0.0	-0.1	0.1	0.2	-0.1
Diastolic blood pressure, automated reading	0.2	0.8	2.0	0.1	0.1	-0.6	1.4	1.2	-1.1	0.6
Ever depressed for a whole week	0.4	0.5	1.8	-0.1	-0.2	0.8	-0.7	-1.3	-0.3	-0.3
Unable to work because of sickness or disability	0.8	1.1	4.4	-0.5	-2.1	-0.1	-0.7	-0.9	0.1	-1.2
Commuting to job workplace: Cycle	0.2	0.2	0.7	-0.1	0.4	0.8	-0.2	-0.3	-0.2	0.8
Myopia	0.8	1.2	2.7	-1.6	0.6	-1.3	1.2	-0.4	0.6	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	7.0	2.6	0.7	2.5	-1.6	0.7	-0.7	-0.4
Cholesterol lowering medication	1.3	1.9	6.4	-2.5	-1.4	-0.6	0.7	-0.6	1.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.8	-0.7	-0.2	-1.0	1.3	0.8	0.4	-0.5
Pain experienced in last month	1.0	1.6	3.6	1.6	-0.8	1.5	-1.3	-0.4	-1.9	0.3
Supplements: Calcium	1.9	2.0	4.8	1.7	0.3	1.8	-0.5	2.2	-0.4	1.7
Basal cell carcinoma (self-reported)	1.6	1.9	7.3	-1.6	-1.0	-1.1	-0.7	-0.9	2.7	-0.6
Heart attack/myocardial infarction (self-reported)	4.2	5.4	11.0	-3.0	-1.8	-3.3	0.6	-1.4	1.1	-3.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	3.5	-0.8	0.4	-1.9	0.2	0.1	-0.1	-0.6
Heart disease (siblings)	0.3	0.4	1.0	-0.9	0.4	-0.1	-0.0	0.9	1.0	-0.5
Alcohol drinker status: Previous	2.9	3.4	8.6	2.3	1.1	1.4	-0.2	2.0	-1.4	2.9
Pack years of smoking	0.9	1.3	6.0	0.5	-0.8	0.7	-0.8	0.9	-0.3	2.5
Impedance of whole body	0.4	2.0	7.5	2.7	1.0	1.8	0.5	0.9	-0.6	1.0
Leg fat mass (left)	0.4	1.5	5.4	1.1	0.5	1.0	1.2	2.3	-1.1	-0.5
Arm predicted mass (left)	0.2	0.8	4.2	-0.5	-0.8	-0.2	-0.3	-0.2	-0.3	-2.1