TWAS hub - SCIN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0970	0.0273	1.1e-07	0.069	0.065	0.067	0.067	0.069	1.5e-10	6.0e-10	2.7e-10	3.0e-10	1.5e-10
2	ROSMAP	Brain Pre-frontal Cortex	0.0778	0.0280	6.8e-04	0.052	0.024	0.056	0.049	0.066	3.1e-07	3.5e-04	9.4e-08	6.1e-07	6.8e-09
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0467	0.0203	4.5e-04	0.003	0.031	0.023	NA	0.013	1.3e-01	1.8e-04	1.0e-03	NA	1.2e-02
4	TCGA	Prostate Adenocarcinoma	0.0787	0.0333	2.7e-03	0.041	0.022	0.008	NA	0.022	4.0e-05	2.1e-03	4.5e-02	NA	2.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Angina (self-reported)	5.0	6.5	15.5	-3.2	0.4	3.9	-0.5
Medication: Gliclazide	4.0	4.6	8.7	-2.7	1.4	2.9	0.3
Angina	3.8	5.0	11.9	-2.8	0.3	3.4	-0.5
Neck or shoulder pain in last month	2.9	4.1	6.6	1.9	-2.6	-2.3	1.0
Myopia	2.8	4.1	9.6	2.3	-3.1	-1.0	-0.6
Had major operations	2.7	3.2	7.5	2.2	-0.3	-2.7	-0.6
Hearing difficulty/problems with background noise	2.5	4.0	4.9	2.1	-2.2	-1.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	7.6	-1.8	-0.7	2.8	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	4.2	2.0	-1.5	-1.9	-1.5
Ever had prostate specific antigen (PSA) test	2.3	2.7	6.5	1.9	-0.1	-2.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	5.8	2.3	-2.4	-1.5	-0.7
Medication: Lisinopril	2.2	2.8	10.7	-0.3	0.5	0.4	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.6	1.1	-2.1	-0.8	-2.1
Alcohol intake frequency.	2.0	4.6	9.8	-1.3	-0.2	3.1	-2.6
Age started oral contraceptive pill	2.0	2.5	4.8	2.1	-0.9	-2.2	0.3
Reaction Time	1.9	3.6	10.7	-3.3	0.5	1.6	-1.1
Medication: Co-codamol	1.9	2.2	4.8	-2.2	1.9	0.7	0.3
Emphysema/chronic bronchitis	1.9	2.1	3.2	-1.8	1.5	1.0	-1.4
Long-standing illness, disability or infirmity	1.9	2.9	10.3	-0.3	-0.4	1.0	-3.2
Ever had bowel cancer screening	1.9	2.2	4.1	2.0	-1.4	-1.3	-0.9
Tinnitus: Yes, now most or all of the time	1.9	2.3	7.5	-0.8	0.9	0.3	-2.7
Alzheimer’s Disease (in mother)	1.8	2.1	4.3	2.0	-0.2	-2.1	0.2
Supplements: Glucosamine	1.8	2.3	3.8	1.9	-0.7	-1.9	1.2
Knee pain experienced in last month	1.8	2.8	4.9	1.7	-2.2	-1.9	0.1
LDL Cholesterol	1.7	2.6	5.1	-2.2	1.2	1.9	0.7
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	6.2	0.4	-1.2	1.1	-2.5
Sitting height	1.7	12.1	18.7	4.3	-3.5	-4.2	0.2
Chronic bronchitis/emphysema (father)	1.7	2.0	4.1	2.0	-1.8	-0.1	0.9
Shortness of breath walking on level ground	1.7	2.0	4.5	-1.4	-0.1	2.1	-1.3
Alcohol drinker status: Never	1.7	2.0	5.4	-1.2	-0.6	2.3	-0.9
Relative age voice broke	1.6	2.5	8.2	-0.6	1.2	-0.0	2.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.2	-1.3	2.3	0.9	0.6
Number of full brothers	1.6	2.0	5.8	0.2	-2.4	0.2	1.5
Illnesses of father: Heart disease	1.6	2.2	3.2	-1.8	0.7	1.7	1.6
Average weekly red wine intake	1.6	2.3	3.6	-1.9	1.7	1.7	-0.2
Major Depression (MDD)	1.5	1.9	3.2	-1.8	0.9	0.7	-1.7
Crohns Disease (2012)	1.5	2.5	4.3	2.0	-1.2	-2.1	-0.4
Diabetes (self-reported)	1.5	2.3	6.6	-1.5	-0.2	2.6	-0.7
Medication: Amlodipine	1.5	2.1	3.6	0.1	-1.2	1.8	-1.9
Mean time to correctly identify matches	1.5	2.8	7.5	-2.7	0.3	1.7	-0.9
Number of self-reported non-cancer illnesses	1.5	2.7	4.3	1.3	-2.1	0.9	-2.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.6	-0.4	-1.4	2.1	0.9
Taking other prescription medications	1.4	2.1	6.3	0.8	-1.2	0.4	-2.5
Heart attack	1.4	1.8	4.3	-0.5	-1.3	2.1	0.9
Standing height	1.4	13.9	30.4	4.4	-2.3	-5.5	0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	5.2	0.6	1.2	-2.3	1.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	7.1	-0.4	-2.7	1.8	0.4
Coronary Artery Disease (CAD)	1.3	1.5	2.7	1.6	-0.9	-1.5	-0.4
Medication: Simvastatin	1.3	1.8	6.2	0.5	-0.9	-0.3	-2.5
Alcohol intake versus 10 years previously	1.3	2.0	5.4	-0.5	0.5	1.4	-2.3
Medication: Lansoprazole	1.3	1.5	4.3	-0.6	-0.1	1.2	-2.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.1	-0.2	1.6	-2.0	-0.6
Eye problems/disorders: None of the above	1.3	1.5	3.2	0.6	0.7	-1.8	1.4
Cholesterol lowering medication	1.3	1.9	4.9	-1.4	0.8	-0.4	-2.2
Supplements: Calcium	1.3	1.4	4.3	-0.7	0.0	2.1	-0.8
Ovarian Cancer	1.2	1.6	2.6	1.2	-1.6	-1.3	-0.7
Relative age of first facial hair	1.2	2.4	3.6	-1.8	1.9	1.6	0.4
Average weekly fortified wine intake	1.2	1.4	2.4	-1.2	-0.3	1.5	1.2
Nervous feelings	1.2	2.2	4.7	2.2	-1.2	-1.3	-1.1
Pain all over the body in last month	1.2	1.2	4.0	-0.9	-0.0	2.0	-0.3
Depression (self-reported)	1.2	1.4	2.4	1.3	-1.6	-0.8	-0.9
Exposure to tobacco smoke at home	1.2	1.4	3.9	-0.8	2.0	-0.5	-0.9
Family relationship satisfaction	1.2	1.4	3.2	1.8	-1.3	-1.0	-0.1
Friendships satisfaction	1.2	1.4	2.2	1.4	-1.5	-0.7	-1.1
Ever taken oral contraceptive pill	1.2	1.3	2.4	0.4	-1.5	-1.3	1.0
Pain experienced in last month	1.2	1.9	3.3	-1.4	1.8	1.4	0.6
HDL Cholesterol	1.1	1.8	3.0	1.6	-1.1	-1.7	0.8
Medication: Ramipril	1.1	1.5	2.9	-0.4	-0.9	1.4	1.7
Asthma	1.1	2.1	4.0	-2.0	1.8	0.9	0.7
Blood clot in the leg (DVT)	1.1	1.4	3.0	1.3	-1.7	0.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.3	1.1	-0.9	-1.5	-0.9
Age at First Birth	1.0	1.4	3.7	-1.9	0.7	1.2	0.4
Mean Putamen Volume	1.0	1.1	3.6	-0.3	-0.7	0.6	1.9
Cardiovascular Disease	1.0	3.4	10.2	1.3	-1.4	0.1	-3.2
Diabetes (mother)	1.0	1.3	1.6	-1.2	-1.0	1.3	-1.1
Had other major operations	1.0	1.3	2.3	0.8	0.3	-1.5	-1.5
Tense / ‘highly strung’	1.0	1.6	3.1	1.5	-1.8	-0.8	-0.8
Birth weight of first child	1.0	1.9	4.3	2.1	-1.5	-0.9	-0.2
Loud music exposure frequency	1.0	1.1	1.7	-0.4	-1.3	1.3	-0.9
Medication: Paracetamol	1.0	1.6	5.0	0.9	0.6	-2.2	-0.5
Medication: Seretide 50 evohaler	1.0	1.2	2.9	-1.4	1.7	-0.1	0.2
Comparative height size at age 10	1.0	5.5	13.2	2.8	-1.0	-3.6	-0.2
Number of full sisters	1.0	1.2	4.1	-0.3	0.2	0.7	-2.0
Diabetes diagnosed by doctor	1.0	1.7	5.1	-1.1	-0.2	2.3	-0.5
Back pain experienced in last month	1.0	1.4	5.6	0.5	-2.4	0.0	0.0
Asthma (self-reported)	1.0	2.1	4.3	-2.1	1.7	0.8	0.6
Smoking status: Current	1.0	1.6	2.9	1.3	-1.1	-1.7	-0.7
Medication: Paracetamol	1.0	1.5	4.1	1.0	0.3	-2.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.5	1.5	-1.6	-0.2	0.5
Height	0.9	16.6	26.4	4.7	-3.1	-5.1	2.9
Medication: Metformin	0.9	1.3	3.1	-0.3	-1.3	1.7	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.9	0.8	-0.6	0.7	-2.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	0.9	-1.0	-1.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.0	1.2	-0.6	-2.0	1.2
Mood swings	0.9	1.7	3.0	-1.2	1.4	0.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	4.4	-1.7	0.9	2.1	0.2
Ever depressed for a whole week	0.9	1.1	2.4	-1.0	0.1	1.6	-1.0
Vascular/heart problems diagnosed by doctor	0.9	2.3	5.7	0.5	0.5	-1.8	2.4
Smoking Status	0.8	1.9	3.4	1.9	-1.4	-1.4	-0.4
Respiratory disease	0.8	1.8	3.3	-1.7	1.8	0.8	0.6
Lung FVC	0.8	3.9	6.7	-2.3	1.6	0.8	2.6
Ever had hysterectomy (womb removed)	0.8	0.9	3.3	0.0	-0.2	0.5	1.8
Length of working week for main job	0.8	0.9	1.8	-1.2	-0.4	1.3	0.5
Breastfed as a baby	0.8	1.0	2.7	0.6	-0.9	0.2	-1.6
Pulse wave reflection index	0.8	0.9	2.2	1.1	-1.5	-0.3	0.5
Medication: Blood pressure	0.8	1.4	3.8	-0.7	-0.8	1.9	-0.9
Medication: Allopurinol	0.8	1.1	2.4	0.8	-0.9	0.8	1.6
Financial situation satisfaction	0.8	1.0	1.8	1.0	-0.7	-0.8	-1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	-0.4	-0.9	1.0	-1.4
Irritability	0.8	1.3	2.1	1.4	-1.4	-1.0	-0.3
Risk taking	0.8	1.2	2.0	0.5	-1.4	-0.9	-1.3
Neuroticism (2016)	0.7	1.0	1.9	1.1	0.5	-1.4	-0.8
Rheumatoid Arthritis	0.7	1.0	2.9	1.0	-0.0	-1.7	0.1
Hearing difficulty/problems: Yes	0.7	1.1	1.5	1.1	-1.2	-0.8	-0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.4	0.1	-1.0	1.2	-0.7
Impedance of leg (right)	0.7	3.3	9.4	1.7	-0.1	-3.1	0.9
Current tobacco smoking	0.7	1.1	1.4	1.1	-1.2	-1.1	-0.9
High blood pressure	0.7	1.9	6.6	0.2	-0.4	0.9	-2.6
Forced vital capacity (FVC)	0.7	2.6	4.1	1.5	-0.6	-2.0	1.9
Financial difficulties in last 2 years	0.7	1.0	1.3	1.1	-1.1	0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.9	0.8	-1.4	-1.3	0.5
Trunk predicted mass	0.7	3.7	7.5	2.2	-1.6	-2.7	0.5
Number of children fathered	0.7	0.8	2.3	-0.6	1.5	-0.1	-0.8
Migraine (self-reported)	0.7	0.8	3.0	0.0	-0.5	1.7	-0.2
Hypertension (Self-reported)	0.7	2.0	7.8	0.3	0.1	0.5	-2.8
Medication for cholesterol	0.7	1.0	3.1	0.1	-0.3	1.0	1.8
Eye problems/disorders: Glaucoma	0.7	0.9	1.9	-1.1	-0.3	1.4	-0.4
Medication: Blood pressure	0.7	1.4	2.4	1.1	-0.3	-1.5	-1.4
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.9	0.6	-0.3	-0.7	1.7
High cholesterol (Self-reported)	0.7	1.2	4.5	-0.0	-0.6	0.3	-2.1
Fractured/broken bones in last 5 years	0.7	0.9	2.5	-0.3	-0.7	0.6	1.6
Pack years of smoking	0.7	1.0	2.5	-0.7	-0.7	1.6	0.9
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.1	-0.9	-0.3	1.7	1.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	5.4	-0.0	-0.2	-0.1	2.3
Fasting Glucose	0.6	0.7	2.3	0.3	0.7	-0.0	-1.5
Primary Biliary Cirrhosis	0.6	0.9	1.6	-0.7	1.2	-0.2	-1.2
Hand grip strength (left)	0.6	1.5	3.6	0.1	1.2	-1.9	1.0
Number of treatments/medications taken	0.6	1.1	2.1	0.8	-1.2	-0.2	-1.4
Maternal smoking around birth	0.6	0.9	2.6	0.1	0.5	-0.8	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	-0.6	1.1	-0.5	0.8
Medication: Atenolol	0.6	0.8	1.0	0.9	-1.0	-0.8	0.8
Medication: Levothyroxine sodium	0.6	1.0	2.0	-0.8	-1.2	1.4	-0.3
Trunk fat mass	0.6	2.5	4.3	1.9	-2.1	-0.8	-1.1
Impedance of arm (right)	0.6	3.0	4.3	2.1	-1.2	-2.0	1.5
Trunk fat-free mass	0.6	3.5	7.1	2.1	-1.6	-2.7	0.3
Time employed in main current job	0.6	0.7	1.3	0.8	-1.1	-0.0	0.8
Medication: Cholesterol lowering	0.6	0.9	1.5	0.8	-1.2	0.7	-0.9
Pulse wave Arterial Stiffness index	0.6	0.8	2.2	1.5	-0.6	-0.6	0.3
Glaucoma (self-reported)	0.6	0.8	1.7	-0.6	-0.6	0.8	-1.3
Suffer from ‘nerves’	0.6	0.9	1.6	1.1	-1.3	-0.9	-0.2
Overall health rating	0.6	1.2	3.9	0.5	-2.0	0.1	0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.3	-0.6	0.7	0.8	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	-1.2	-0.7	0.8	-0.3
Commuting to job workplace: Walk	0.6	0.6	2.1	0.3	-0.3	0.3	1.4
Eye problems/disorders: Cataract	0.6	0.6	2.2	0.4	0.4	-0.1	-1.5
Mineral and other dietary supplements	0.6	0.8	1.2	-1.1	0.7	0.6	-1.1
Breast cancer (self-reported)	0.6	0.7	1.4	0.8	0.7	-0.7	-1.2
Medication: Aspirin	0.6	0.8	3.1	-0.4	0.0	1.8	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.0	0.4	-0.3	-0.7	-1.4
Wears glasses or contact lenses	0.6	0.7	1.2	0.9	-0.8	-0.3	-1.1
Mother’s age at death	0.6	0.8	2.6	-0.8	1.6	-0.0	-0.0
Basal metabolic rate	0.6	3.1	4.8	2.1	-1.8	-2.2	-0.3
Number of operations (self-reported)	0.6	0.9	1.2	1.1	-0.4	-1.1	-1.1
Average weekly beer plus cider intake	0.6	0.9	1.8	1.1	-1.3	-0.8	0.3
Alcohol drinker status: Previous	0.6	0.7	2.5	-0.4	-0.3	1.6	-0.0
Depression (Nagel 2018)	0.5	0.8	0.8	0.9	-0.9	-0.9	-0.9
Schizophrenia (2018)	0.5	1.1	3.6	0.2	-0.6	-0.7	1.9
HbA1C	0.5	0.5	1.5	0.7	0.1	-1.2	-0.1
Schizophrenia (2014)	0.5	1.0	3.1	-0.3	-0.5	-0.8	1.8
Average weekly spirits intake	0.5	0.7	1.4	1.2	-0.8	-0.6	0.5
Pack years adult smoking proportion	0.5	0.8	1.3	-0.6	-0.6	1.0	1.1
Leg fat-free mass (left)	0.5	2.8	4.5	1.9	-2.1	-1.7	-0.2
Townsend deprivation index at recruitment	0.5	0.7	2.1	-0.7	-0.3	0.4	-1.4
Multivitamins +/- minerals	0.5	0.7	1.9	0.6	0.3	-1.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.2	1.1	-0.8	0.4	0.4
Leg predicted mass (left)	0.5	2.7	4.3	1.9	-2.1	-1.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.9	0.8	-1.4	0.3	-0.6
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-1.1	-0.6	0.6	0.7
Had menopause	0.5	0.6	1.2	-0.0	-0.2	1.1	1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.8	1.3	0.5	-0.0
Falls in the last year	0.5	0.7	1.6	1.1	-0.1	-1.3	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	-0.8	1.3	0.4	-0.5
Happiness	0.5	0.5	1.3	0.7	-1.1	0.3	0.6
Gout (self-reported)	0.5	0.6	1.5	-0.4	0.0	1.2	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.5	0.5	0.0	0.6	-1.2
Forced vital capacity (FVC), Best measure	0.5	2.0	4.9	0.6	0.2	-1.7	2.2
Pulse wave peak to peak time	0.5	0.6	1.9	-1.4	0.6	0.4	-0.2
Medication: Ibuprofen	0.5	0.6	1.0	0.2	0.8	-1.0	-0.8
Heart disease (mother)	0.5	0.5	1.0	0.0	-0.5	1.0	-0.9
Chest pain or discomfort	0.5	0.6	1.8	0.0	-0.8	0.3	-1.4
Medication: Aspirin	0.5	0.6	2.3	-0.1	-0.5	1.5	0.2
Whole body fat-free mass	0.5	3.0	5.2	2.0	-1.7	-2.3	-0.0
Whole body water mass	0.5	2.6	4.5	1.9	-1.6	-2.1	-0.2
Miserableness	0.5	0.9	1.7	-0.7	1.3	0.8	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.2	-0.7	1.1	0.7	0.0
Commuting to job workplace: Cycle	0.5	0.6	1.7	0.4	0.8	-1.3	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	0.2	-0.7	-1.3	-0.3
Worry (Nagel 2018)	0.4	0.8	1.6	-0.0	-1.2	1.3	-0.4
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.9	0.1	-0.9	-0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	0.9	0.6	-1.1	-0.1
Crohns Disease (2017)	0.4	1.0	2.5	1.0	-1.6	0.2	-0.5
Breast Cancer	0.4	0.9	2.9	-0.1	0.2	0.7	-1.7
Prostate Cancer	0.4	0.5	1.9	0.4	-0.1	-1.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.4	-0.2	-0.6	-1.2
Blood Red Count	0.4	4.3	8.5	-2.2	0.6	2.9	-1.9
Hypothyroidism (self reported)	0.4	0.9	1.8	-0.4	-1.2	1.3	0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	0.0	-0.5	1.4	-0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	1.1	-0.0	-0.7	-0.8
Diabetes (father)	0.4	0.5	1.3	0.1	1.1	-0.5	-0.8
Trunk fat percentage	0.4	1.6	3.3	1.4	-1.8	-0.1	-1.1
Hand grip strength (right)	0.4	1.2	2.4	0.5	0.6	-1.6	1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.9	0.5	0.5	-0.7
Impedance of leg (left)	0.4	2.0	6.4	1.1	0.5	-2.5	-0.1
Fluid intelligence score	0.4	0.8	2.6	0.6	0.3	-0.1	1.6
Illnesses of siblings	0.4	0.5	1.4	0.2	0.7	-1.2	0.3
Weight	0.4	1.8	3.2	1.5	-1.8	-1.1	-0.7
Father’s age at death	0.4	0.5	0.8	0.7	0.4	-0.9	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	1.5	-0.8	-1.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	0.2	0.7	-1.2	0.1
Illnesses of mother	0.4	0.4	0.8	0.1	-0.9	-0.5	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-0.7	-0.5	1.1	0.4
Body fat percentage	0.4	1.4	2.3	1.2	-1.5	-0.2	-1.3
Arm fat-free mass (right)	0.4	1.9	3.1	1.4	-1.3	-1.8	-0.9
Whole body fat mass	0.4	1.8	2.9	1.5	-1.7	-0.8	-1.3
Arm predicted mass (right)	0.4	2.1	3.4	1.7	-1.4	-1.8	-0.7
Smoking status: Previous	0.4	0.6	1.2	-0.5	-0.2	1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.2	-1.1	0.6	0.5	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.5	-0.3	0.8	-1.1
Illnesses of father: High blood pressure	0.4	0.5	1.5	-1.2	0.3	0.6	0.4
Arm fat-free mass (left)	0.4	1.8	3.8	1.5	-1.1	-1.9	-0.4
Unable to work because of sickness or disability	0.4	0.6	1.7	-1.3	-0.6	0.5	-0.3
Impedance of whole body	0.4	2.0	4.4	1.8	-0.3	-2.1	0.4
Leg fat mass (left)	0.4	1.5	2.5	1.0	-1.5	-0.5	-1.6
Arm predicted mass (left)	0.4	1.8	3.9	1.4	-1.0	-2.0	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	1.4	0.4	-0.4	-1.1	1.2
Schizophrenia vs Biploar Disorder	0.3	0.3	1.2	0.2	0.2	-0.1	1.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	0.8	-1.3	0.0	-0.5
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.8	0.7	0.1	-0.8
Ulcerative Colitis	0.3	0.4	1.0	-1.0	0.6	0.2	-0.5
Lung FEV1/FVC ratio	0.3	1.3	1.8	1.2	-1.3	0.4	-1.3
Chronotype (morning person)	0.3	0.8	1.4	-1.2	-0.5	1.1	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.1	-0.4	0.2	1.1
Vitamin and mineral supplements	0.3	0.4	1.1	-0.7	0.1	1.0	-0.3
Supplements: Zinc	0.3	0.4	1.0	-1.0	0.5	-0.1	0.4
Severe depression (siblings)	0.3	0.3	0.6	-0.6	0.3	0.5	0.8
Fed-up feelings	0.3	0.6	0.9	0.9	-0.7	-0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-0.9	-0.5	0.6	1.2
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.8	0.1	-0.2	-0.8
Body mass index (BMI)	0.3	1.1	2.0	-0.6	-0.6	1.4	-1.2
Mouth/teeth dental problems	0.3	0.4	1.0	-0.7	0.5	1.0	0.1
Arm fat percentage (right)	0.3	1.0	2.7	0.7	-1.6	0.3	-0.8
Worrier / anxious feelings	0.3	0.5	1.4	0.8	-1.2	-0.0	0.3
Number of live births	0.3	0.5	1.7	-0.1	0.3	-0.0	1.3
Prospective memory result	0.3	0.4	0.9	-0.7	-0.5	0.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.3	0.7	-0.2	-1.2	1.5
Impedance of arm (left)	0.3	1.4	2.9	1.7	-0.7	-1.3	0.8
Birth weight	0.3	0.7	2.4	0.6	-1.6	0.0	-0.3
High blood pressure (siblings)	0.3	0.4	1.2	0.4	-1.1	0.6	-0.2
Worry too long after embarrassment	0.3	0.6	1.9	-0.4	1.4	-0.4	0.1
Age at first live birth	0.3	0.5	1.0	-1.0	1.0	0.5	0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.2	-0.7	-0.1	1.1	-0.7
Leg fat mass (right)	0.3	1.3	2.6	1.2	-1.6	-0.6	-1.0
Leg fat-free mass (right)	0.3	1.7	3.1	1.5	-1.8	-1.2	-0.4
Arm fat percentage (left)	0.3	1.3	2.9	0.8	-1.7	0.5	-1.2
Leg predicted mass (right)	0.3	1.6	2.8	1.5	-1.7	-1.2	-0.4
Average weekly champagne plus white wine intake	0.3	0.3	0.8	-0.0	0.2	-0.7	0.9
Guilty feelings	0.3	0.4	1.0	0.0	0.5	-0.6	1.0
Diastolic blood pressure, automated reading	0.3	0.9	1.7	-0.5	1.3	0.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.3	0.4	0.2	1.1
Bipolar Disorder (2018)	0.2	0.3	0.9	0.4	0.1	-0.9	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.2	-0.6	1.0	-0.5
Lupus	0.2	0.3	0.6	-0.8	-0.5	0.5	-0.3
Triglycerides	0.2	0.3	1.0	0.1	0.2	-0.1	-1.0
BMI	0.2	1.4	3.3	-0.9	0.2	1.8	-1.2
Systolic Blood Pressure	0.2	0.9	2.1	-0.2	0.5	1.1	-1.4
High blood pressure (mother)	0.2	0.3	0.5	-0.2	0.7	-0.5	0.5
Waist circumference	0.2	0.7	2.2	0.5	-1.5	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	-0.6	-0.2	0.4	1.1
Hip circumference	0.2	0.9	1.8	0.9	-1.4	-0.6	-0.7
Arm fat mass (right)	0.2	0.9	2.3	0.9	-1.5	-0.2	-0.8
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.2	-0.9	0.5	-0.8
Headache pain in last month	0.2	0.3	0.9	0.2	0.2	-0.5	-1.0
Comparative body size at age 10	0.2	0.6	1.2	-1.1	0.7	0.7	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.1	-0.7	0.2	-1.0
Medication: Omeprazole	0.2	0.3	0.4	-0.6	0.7	0.6	0.2
Age at last live birth	0.2	0.3	0.7	-0.5	0.8	0.4	-0.4
Leg pain on walking	0.2	0.3	0.8	0.2	-0.9	-0.6	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.5	0.4	0.5	-0.3
Supplements: Vitamin C	0.2	0.2	0.6	-0.1	0.3	-0.6	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	-0.0	-0.6	0.8	-0.4
Loneliness, isolation	0.2	0.3	0.8	0.1	-0.9	0.6	-0.3
Arm fat mass (left)	0.2	0.8	1.8	0.8	-1.3	-0.1	-0.9
Medication: Bendroflumethiazide	0.2	0.4	0.7	0.6	-0.8	-0.1	0.7
Medication: Atorvastatin	0.2	0.3	0.5	-0.7	-0.1	0.7	0.4
Leg fat percentage (left)	0.2	0.7	2.5	0.3	-0.5	0.1	-1.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.2	-0.1	0.7	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.4	-0.7	-0.4	0.2
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	-0.5	0.0	0.0
Blood Eosinophil Count	0.1	1.1	3.1	0.8	-1.8	-0.6	-0.4
Blood Platelet Count	0.1	0.7	1.8	-0.5	0.1	0.9	-1.4
Blood White Count	0.1	0.7	2.6	-0.1	-0.2	1.6	-0.5
Heel T-Score	0.1	0.6	1.0	1.0	-1.0	-0.5	-0.3
Allergy or Eczema	0.1	0.2	0.5	-0.6	0.7	0.3	-0.0
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.1	0.7	0.7	-0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.5	0.0	-0.7	0.1	0.0
Number of incorrect matches in round	0.1	0.1	0.4	0.1	0.2	-0.3	0.6
Past tobacco smoking	0.1	0.1	0.2	0.5	0.1	-0.4	-0.2
Alcohol usually taken with meals	0.1	0.2	0.4	-0.7	0.3	0.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.4	0.0	0.6	-0.3
Qualifications: None of the above	0.1	0.2	0.7	-0.0	-0.8	-0.3	0.1
Neuroticism score	0.1	0.1	0.3	0.3	0.0	-0.5	-0.3
Pulse rate	0.1	0.2	0.2	0.4	-0.2	0.4	0.5
Noisy workplace	0.1	0.1	0.2	-0.4	0.2	-0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	0.2	-0.2	-0.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.0	-0.6	0.0	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.6	-0.2	0.2	0.6
Lung cancer (father)	0.1	0.1	0.2	0.2	-0.2	0.2	-0.5
Peak expiratory flow (PEF)	0.1	0.1	0.5	0.7	0.1	-0.1	-0.3
Leg fat percentage (right)	0.1	0.5	0.8	0.6	-0.8	-0.2	-0.9
Health satisfaction	0.1	0.1	0.3	-0.3	0.0	-0.3	-0.5
Qualifications: College or University degree	0.1	0.3	0.6	0.6	-0.2	-0.8	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	0.4	0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	-0.3	0.4	0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.4	-0.2	0.5	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.3	0.1	-0.7	-0.2
Hearing aid user	0.1	0.2	0.3	0.6	0.0	0.3	-0.5
Ever smoked	0.1	0.1	0.2	0.1	-0.3	-0.4	0.3
Heart disease (siblings)	0.1	0.1	0.2	0.1	-0.2	0.3	-0.4
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.0	-0.3	0.0	-0.1
Neuroticism	0.0	0.1	0.2	-0.3	-0.3	0.5	0.2
Hair Pigment	0.0	0.2	0.3	0.4	-0.6	-0.2	-0.5
Tanning	0.0	0.1	0.2	0.2	-0.1	-0.4	0.0
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.1	0.0	0.1	0.3
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	0.3	0.2	-0.2
Age when periods started (menarche)	0.0	0.1	0.2	-0.2	-0.2	0.1	0.4
Qualifications: CSEs or equivalent	0.0	0.1	0.2	-0.2	-0.0	-0.1	-0.5
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.1	0.3	-0.3	0.0
Allergy	0.0	0.1	0.2	0.4	-0.2	0.0	-0.5
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.2	0.0	-0.2	-0.3
Exposure to tobacco smoke outside home	0.0	0.1	0.1	-0.1	0.0	0.3	0.4
Pulse rate, automated reading	0.0	0.1	0.3	0.5	0.2	-0.2	-0.0
Osteoarthritis (self-reported)	0.0	0.1	0.2	0.4	-0.1	-0.2	0.2

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