Hub : Genes

SCML4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0230	2.5e-06	0.027	0.050	0.065	0.050	0.063	2.5e-04	9.9e-07	2.3e-08	9.6e-07	3.7e-08
2	ROSMAP	Brain Pre-frontal Cortex	0.0846	0.0247	5.0e-06	0.016	0.046	0.024	0.044	0.035	2.9e-03	1.4e-06	3.5e-04	2.4e-06	2.5e-05
3	YFS	Blood	0.2733	0.0334	0.0e+00	0.118	0.246	0.255	0.248	0.260	1.5e-36	1.2e-79	8.3e-83	3.3e-80	1.4e-84
4	TCGA	Liver Hepatocellular Carcinoma	0.0880	0.0460	5.6e-03	0.014	0.025	0.065	NA	0.067	7.1e-02	2.5e-02	5.6e-04	NA	4.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.8	0.4	-0.2	-0.9	-0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	4.8	0.7	0.2	-2.2	-0.2
Depressed Affect (Nagel 2018)	1.2	2.6	7.6	-0.9	-1.4	0.3	2.8
Depression (Nagel 2018)	0.6	0.8	1.4	-0.8	-1.2	-1.1	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.7	-0.1	-0.6	1.1	-1.3
Neuroticism (Nagel 2018)	1.3	3.1	7.0	-1.0	-1.8	-1.2	2.6
Schizophrenia (2018)	0.6	1.3	4.4	0.6	0.6	-2.1	0.1
Schizophrenia vs Biploar Disorder	4.5	5.9	9.8	3.1	1.3	-2.4	-2.5
Worry (Nagel 2018)	0.9	1.9	3.6	-0.7	-0.8	-1.9	1.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.2	0.3	1.2	-0.5
Alzheimer’s Disease (in father)	0.6	0.7	1.3	-1.1	-0.8	-0.3	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	-0.9	-0.8	1.8	0.2
Crohns Disease (2017)	0.1	0.2	0.4	-0.7	-0.5	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	-0.6	-0.5	-1.1	0.8
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.7	-0.6	-0.6	1.1
Major Depression (MDD)	1.1	1.3	4.0	-1.0	-2.0	0.4	0.5
Reaction Time	1.6	3.1	4.9	1.6	2.2	-1.2	-1.9
Verbal and Numeric Reasoning (VNR)	1.6	3.8	11.5	-1.1	-1.5	3.4	-0.3
Breast Cancer	0.3	0.7	1.3	-0.1	1.1	1.1	-0.3
Ovarian Cancer	0.8	1.1	4.0	-0.4	0.2	-0.5	2.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.7	0.9	2.1	-1.1	-1.5	0.5	0.4
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.6	-0.9	0.4	0.4
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	0.9	1.3	0.5	-1.3
Coronary Artery Disease (CAD)	0.3	0.4	0.9	-0.5	0.9	0.6	0.1
Crohns Disease (2012)	0.1	0.2	0.5	-0.7	-0.5	0.0	0.2
Mean Putamen Volume	1.9	2.2	4.9	1.4	0.9	-2.2	-1.0
Fasting Glucose	0.2	0.3	0.5	0.7	-0.3	-0.6	-0.4
HbA1C	0.5	0.6	1.5	0.5	0.5	-0.7	-1.2
HDL Cholesterol	0.2	0.4	1.1	0.3	0.3	-1.0	-0.5
LDL Cholesterol	0.5	0.8	1.2	1.0	1.0	-1.1	-0.1
Lupus	0.4	0.7	1.5	-0.8	-1.2	0.7	0.3
Neuroticism (2016)	0.7	1.0	2.2	-1.5	-0.5	0.4	1.1
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.1
Rheumatoid Arthritis	0.5	0.7	2.6	0.1	-0.3	1.6	-0.2
Schizophrenia (2014)	1.7	3.7	8.8	1.3	1.4	-3.0	-1.5
Triglycerides	0.2	0.3	0.9	-0.3	0.2	-0.3	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.4	0.4	-1.2	-0.0	-0.3
Ulcerative Colitis	0.5	0.8	2.7	-0.0	0.5	0.2	1.7
Blood Eosinophil Count	0.7	5.1	7.7	-2.3	-0.9	2.8	2.5
Blood Platelet Count	0.1	1.2	1.8	-0.5	-1.2	1.2	-1.4
Blood Red Count	0.0	0.3	0.7	0.0	0.9	-0.3	-0.5
Blood White Count	2.2	16.1	25.2	4.9	5.0	-2.9	-2.6
Heel T-Score	0.2	1.2	2.2	-1.5	1.1	0.7	0.9
BMI	0.9	5.1	17.1	1.7	4.1	-0.0	-0.5
Height	0.5	8.9	20.2	-2.4	-4.5	-1.1	2.9
Waist Hip Ratio (WHR)	1.0	4.7	12.5	-2.5	-3.5	0.1	0.1
Systolic Blood Pressure	2.0	10.0	19.7	3.2	2.1	-2.3	-4.4
Smoking Status	1.0	2.3	3.7	1.7	-0.5	-1.9	-1.5
Allergy or Eczema	7.7	20.2	26.7	-5.2	-5.0	4.4	3.0
Cardiovascular Disease	0.1	0.2	0.3	0.3	0.5	0.5	-0.4
Hypothyroidism (self reported)	0.4	1.0	2.2	-0.9	-0.9	1.5	-0.2
Respiratory disease	5.8	13.0	23.8	-4.9	-3.6	3.2	2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.9	0.6	0.7	-1.4	0.7
Lung FEV1/FVC ratio	0.6	2.9	6.9	2.6	0.8	-1.6	-1.3
Lung FVC	0.7	3.7	6.5	1.6	2.3	-2.5	-0.4
Neuroticism	0.6	1.5	5.2	-0.7	-0.1	-0.4	2.3
Chronotype (morning person)	0.4	1.0	2.2	-1.1	1.5	0.7	-0.3
Hair Pigment	0.0	1.4	2.7	1.6	1.1	1.1	-0.8
Tanning	0.0	0.5	2.0	0.0	0.0	-1.4	0.3
Hand grip strength (left)	0.6	1.5	3.5	1.6	1.9	0.1	0.3
Number of treatments/medications taken	0.2	0.4	1.5	-0.1	0.2	0.4	-1.2
Average weekly spirits intake	0.4	0.4	1.3	0.1	-0.6	0.4	-1.1
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.5	0.4	0.1	0.9
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.3	-1.8	-1.5	0.1	1.2
Hearing difficulty/problems: Yes	2.2	3.4	10.8	-0.1	-3.3	-1.5	0.8
Relative age of first facial hair	0.8	1.7	5.6	-1.1	-2.4	-0.0	0.1
Other serious medical condition/disability diagnosed by doctor	3.0	3.9	7.8	-2.8	-2.5	0.5	1.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	-0.9	-1.4	-0.7	-0.4
Systolic blood pressure, automated reading	2.6	7.6	9.7	2.6	2.0	-3.1	-3.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.9	0.8	-0.2	-0.8
Angina	0.1	0.1	0.2	-0.4	-0.2	0.4	0.1
Medication for hormone replacement therapy	3.2	3.6	5.8	2.4	1.2	-2.3	-1.4
Vitamin and mineral supplements	1.0	1.4	3.3	1.2	0.8	-0.0	-1.8
Supplements: Zinc	1.1	1.2	1.7	-0.6	-1.3	-1.2	1.2
Medication: Co-codamol	0.7	0.8	3.1	-1.8	-0.0	0.1	-0.1
Medication: Metformin	0.5	0.8	2.3	0.5	0.5	-1.5	0.6
Diabetes (father)	1.3	1.7	3.1	1.3	1.8	-0.4	-1.3
Diabetes (mother)	1.2	1.5	5.3	0.9	-0.1	-2.3	0.1
Severe depression (siblings)	1.5	1.7	5.3	1.0	0.1	-2.3	-0.6
Pack years adult smoking proportion	0.6	0.9	3.1	0.6	1.8	-0.6	0.0
Impedance of leg (right)	0.3	1.3	2.0	-0.9	-1.3	0.7	-1.4
Leg fat-free mass (left)	0.4	2.3	4.8	1.3	2.2	-1.0	1.2
Trunk fat percentage	0.5	2.2	6.9	1.2	2.6	-0.6	-0.2
Hand grip strength (right)	0.8	2.1	4.5	1.6	2.1	-1.1	0.2
Townsend deprivation index at recruitment	4.6	6.4	7.2	2.5	2.7	-2.4	-2.5
Current tobacco smoking	2.2	3.6	7.0	2.2	1.0	-2.6	-1.2
Average weekly fortified wine intake	0.9	1.0	2.6	-0.7	-1.6	0.4	0.9
Maternal smoking around birth	1.1	1.6	5.6	-0.2	-0.7	0.2	2.4
Fed-up feelings	1.3	2.3	7.0	-1.0	-0.7	0.8	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	-0.8	-0.5	-0.8	1.0
Relative age voice broke	0.7	1.1	3.7	-0.5	-1.9	-0.1	-0.7
Taking other prescription medications	0.2	0.4	1.0	-1.0	-0.5	0.0	-0.5
Age when periods started (menarche)	0.1	0.1	0.3	0.5	-0.5	-0.1	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.1	-0.2	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	6.2	-2.5	-0.4	1.9	2.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.0	1.0	0.9	-0.4	-0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.1	-1.0	0.8	-0.1	0.7
Serious illness, injury or assault to yourself	0.4	0.4	0.9	-0.3	-0.5	-1.0	0.7
High blood pressure	0.2	0.5	1.0	1.0	0.5	0.1	-0.8
Hayfever, allergic rhinitis or eczema	6.6	14.4	19.6	-4.4	-4.3	3.7	2.4
Multivitamins +/- minerals	0.3	0.4	1.4	-0.4	0.2	0.1	1.2
Stomach or abdominal pain in last month	2.7	3.4	6.5	2.5	1.2	-1.7	-1.7
Supplements: Glucosamine	0.3	0.4	0.8	-0.6	-0.8	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	1.1	0.4	-0.8	-0.3
Medication: Atenolol	0.1	0.2	0.3	-0.5	-0.6	-0.2	0.1
Medication: Levothyroxine sodium	0.6	1.1	2.7	-1.1	-1.6	0.1	0.6
Sitting height	0.2	1.2	4.1	0.3	0.1	-2.0	0.8
Chronic bronchitis/emphysema (father)	3.1	3.7	7.8	-1.8	-2.8	0.1	1.9
High blood pressure (mother)	0.7	1.0	1.7	1.3	0.3	-1.0	-1.2
Body mass index (BMI)	1.3	5.7	17.4	2.1	4.2	-0.8	-0.7
Impedance of leg (left)	0.3	1.5	3.1	-1.1	-1.8	0.6	-1.1
Leg predicted mass (left)	0.4	2.3	5.0	1.4	2.2	-1.0	1.2
Trunk fat mass	0.5	2.1	6.2	1.2	2.5	-0.8	0.2
Waist circumference	0.4	1.3	3.7	0.9	1.9	-0.8	-0.5
Number of incorrect matches in round	0.9	1.5	3.0	-0.5	-1.5	-1.7	0.6
Past tobacco smoking	1.1	2.0	7.1	-0.2	2.7	-0.5	0.8
Alcohol usually taken with meals	0.8	1.3	2.4	-0.6	-1.5	-0.4	1.6
Nervous feelings	0.2	0.4	1.3	-0.5	0.0	-1.2	0.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	5.9	-2.3	-1.6	-0.0	2.4
Hearing difficulty/problems with background noise	3.1	5.0	11.0	-2.5	-3.3	0.7	1.5
Hair/balding pattern: Pattern 2	1.6	2.0	4.3	-2.1	-0.5	1.5	1.1
Had menopause	0.8	1.1	1.9	0.3	-1.3	-1.4	0.7
Had other major operations	0.9	1.1	3.0	-0.9	-1.7	-0.4	0.7
Forced vital capacity (FVC)	0.5	2.0	7.3	0.6	0.0	-2.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.2	-0.9	0.9	1.8	1.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	0.5	-0.6	-0.5	-0.7
Qualifications: None of the above	0.3	0.7	1.2	1.1	0.9	-0.2	-0.9
Financial difficulties in last 2 years	0.7	0.9	2.0	0.2	1.3	-1.4	0.0
Mouth/teeth dental problems	2.7	4.1	7.2	-1.9	-1.6	1.8	2.7
Heart attack	0.5	0.6	2.3	-0.4	1.5	-0.0	0.2
Allergy	7.3	16.9	27.2	5.2	4.5	-3.7	-2.6
Pain all over the body in last month	0.3	0.3	0.9	-0.9	-0.5	0.3	0.3
Diabetes (self-reported)	0.7	1.0	2.2	-0.0	0.4	-1.5	1.3
Hayfever/allergic rhinitis (self-reported)	7.2	9.5	16.2	-4.0	-3.3	2.8	1.8
Medication: Ramipril	0.1	0.2	0.4	0.5	0.0	-0.6	0.3
Medication: Simvastatin	0.2	0.2	0.5	0.5	0.5	-0.7	0.2
Fluid intelligence score	1.1	2.4	5.4	-1.1	-1.7	2.3	0.1
Illnesses of siblings	1.9	2.6	4.1	-1.5	-1.0	2.0	1.8
Neuroticism score	0.6	1.2	3.9	-0.7	-0.5	-0.0	2.0
Weight	0.5	2.2	7.0	1.1	2.6	-0.9	0.3
Impedance of arm (right)	0.9	4.1	10.2	-2.2	-3.2	0.8	0.9
Arm fat percentage (right)	0.5	1.8	6.5	0.8	2.5	-0.2	0.0
Trunk fat-free mass	0.2	0.9	1.6	0.7	1.1	-1.3	0.8
Hip circumference	1.0	4.3	11.5	2.0	3.4	-1.3	-0.4
Time employed in main current job	0.3	0.4	1.3	0.2	0.1	-1.1	0.5
Alcohol intake versus 10 years previously	0.4	0.6	2.0	0.7	1.4	-0.2	0.0
Father’s age at death	2.3	3.1	6.0	2.5	1.0	-0.8	-2.1
Worrier / anxious feelings	0.9	1.6	2.6	-1.6	-1.1	-0.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.9	-2.2	-0.6	0.8	2.1
Falls in the last year	1.6	2.1	4.8	-1.4	-1.2	0.7	2.2
Hair/balding pattern: Pattern 3	2.1	3.1	5.6	1.5	1.0	-1.9	-2.4
Number of live births	0.7	1.0	2.2	0.9	1.5	-0.9	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.7	1.4	0.7	-2.8	0.2
Pulse rate	0.8	1.3	3.2	1.8	1.2	-0.7	-0.3
Happiness	0.1	0.1	0.5	0.7	0.3	0.0	-0.1
Noisy workplace	0.3	0.4	1.0	0.6	1.0	0.0	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	-0.5	-0.2	0.6	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.9	0.4	-0.2	-1.0
Mouth/teeth dental problems: Dentures	1.0	1.7	3.4	0.7	1.8	-1.0	-1.4
Asthma	5.6	11.1	21.6	-4.6	-3.1	2.5	2.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-0.5	-1.0	1.3	0.9
Medication: Cholesterol lowering	0.3	0.5	1.6	0.3	1.2	0.4	-0.4
Depression (self-reported)	0.9	1.0	1.7	1.3	1.3	-0.5	-0.7
Medication: Lansoprazole	0.9	1.0	2.0	1.4	0.6	-1.2	-0.4
Prospective memory result	0.0	0.0	0.0	-0.2	0.1	0.1	-0.2
Lung cancer (father)	0.5	0.6	1.8	0.7	0.3	-1.3	-0.3
Illnesses of mother	0.8	0.9	1.9	-1.4	-0.0	0.5	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	8.5	1.5	1.3	-2.9	0.3
Pulse wave Arterial Stiffness index	3.3	3.8	5.3	2.3	2.0	-2.0	-1.4
Impedance of arm (left)	0.9	4.2	10.0	-2.3	-3.2	0.9	0.8
Arm fat mass (right)	0.6	2.4	8.3	1.0	2.9	-0.6	0.1
Trunk predicted mass	0.2	0.9	1.5	0.6	1.0	-1.2	0.9
Standing height	0.4	4.4	8.6	-1.8	-2.9	-0.7	2.3
Length of working week for main job	0.4	0.4	1.5	-0.1	1.2	0.0	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.2	-0.4	-0.6	-0.5
Breastfed as a baby	0.2	0.3	0.6	-0.8	-0.2	0.7	-0.2
Tense / ‘highly strung’	0.7	1.2	3.4	-0.4	-0.5	-1.8	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	8.0	-0.6	-2.8	0.2	0.7
Hair/balding pattern: Pattern 4	0.4	1.1	3.6	0.3	-0.7	1.9	-0.0
Birth weight of first child	0.8	1.4	2.2	-1.2	-1.5	0.4	1.4
Peak expiratory flow (PEF)	0.4	0.9	1.4	1.2	0.9	-1.2	-0.5
Pulse wave reflection index	0.6	0.7	1.0	0.8	1.0	0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	-0.3	-1.1	1.1	0.4
Loud music exposure frequency	0.3	0.3	0.8	-0.6	0.2	0.9	0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.4	1.4	1.5	-1.5	-1.5
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.5	1.0	0.7	-1.2	-0.9
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.2	0.0	-0.6	-0.7
Medication: Paracetamol	1.1	1.8	3.6	-1.9	-1.6	1.0	0.4
Headache pain in last month	0.3	0.5	1.7	-0.2	0.4	-1.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.0	-0.4	-0.6	0.4
Glaucoma (self-reported)	0.4	0.5	1.0	0.3	-1.0	-0.3	-0.9
Gout (self-reported)	6.3	8.7	11.4	-2.8	-2.4	3.4	3.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.7	-1.2	-1.3	1.1	0.7
Medication: Amlodipine	0.7	1.0	1.4	0.9	1.2	0.8	-1.0
Medication: Ventolin 100micrograms inhaler	5.3	6.8	14.3	-3.8	-1.1	3.0	1.6
Birth weight	0.6	1.4	2.2	-1.3	-0.9	1.5	0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.6	0.4	-0.1	0.1
High blood pressure (siblings)	0.6	0.8	2.4	0.6	0.0	-1.5	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.7	5.9	0.7	0.1	-2.4	0.7
Body fat percentage	0.7	2.6	8.4	1.2	2.9	-0.6	-0.4
Leg fat percentage (right)	0.9	3.4	9.5	1.7	3.1	-0.4	-1.1
Arm fat-free mass (right)	0.5	2.4	6.1	1.4	2.5	-1.2	0.3
Exposure to tobacco smoke outside home	1.0	1.4	3.9	-0.6	-0.6	-0.9	2.0
Comparative body size at age 10	0.1	0.3	0.5	-0.3	0.6	-0.1	0.7
Number of full brothers	0.3	0.4	0.7	0.5	-0.0	-0.9	0.8
Worry too long after embarrassment	0.2	0.3	0.5	0.7	-0.1	-0.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	6.7	-1.0	-2.6	0.9	0.9
Wheeze or whistling in the chest in last year	1.2	2.2	3.0	-1.7	-1.6	1.7	0.2
Number of children fathered	0.2	0.2	0.4	-0.2	-0.6	-0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.9	-1.0	0.3	-0.1
Age at first live birth	1.5	2.7	6.2	-1.7	-1.0	2.5	0.9
Pulse wave peak to peak time	3.6	4.3	6.0	-2.4	-2.3	1.9	1.6
Health satisfaction	1.0	1.2	2.4	-1.3	-0.0	0.9	1.6
Shortness of breath walking on level ground	0.8	1.0	2.2	-1.5	-0.2	1.2	0.3
Qualifications: College or University degree	1.5	4.7	4.9	-2.2	-2.1	2.2	2.2
Eye problems/disorders: None of the above	0.7	0.8	1.5	-0.8	1.1	-0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	0.5	-0.7	-0.5	-0.9
Emphysema/chronic bronchitis	6.5	7.3	10.6	-3.3	-2.7	3.1	1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	2.3	1.5	0.6	0.7	-0.6
Neck or shoulder pain in last month	0.6	0.9	2.6	-1.6	-0.4	-0.5	0.7
Medication: Blood pressure	0.2	0.3	0.5	0.5	0.4	-0.5	-0.7
Angina (self-reported)	0.0	0.0	0.1	0.2	0.2	0.1	-0.3
Migraine (self-reported)	0.1	0.1	0.1	0.4	-0.3	-0.0	-0.1
Medication: Ibuprofen	1.3	1.5	2.5	-1.1	-1.2	1.6	1.0
Medication: Allopurinol	2.5	3.4	5.9	-1.6	-1.6	1.6	2.4
Medication: Omeprazole	0.2	0.3	1.0	-0.1	-1.0	-0.1	0.3
Medication: Seretide 50 evohaler	4.0	4.6	7.9	-2.8	-1.6	1.7	2.3
Mean time to correctly identify matches	2.1	4.1	8.6	1.9	1.7	-1.1	-2.9
Heart disease (mother)	0.3	0.4	0.7	0.2	-0.5	0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	4.6	2.1	0.8	-2.0	-1.9
Whole body fat mass	0.7	3.0	8.8	1.4	3.0	-1.0	-0.1
Leg fat mass (right)	0.9	3.4	10.3	1.6	3.2	-0.7	-0.3
Arm predicted mass (right)	0.5	2.5	6.3	1.2	2.5	-1.3	0.5
Pulse rate, automated reading	1.8	5.9	10.3	3.2	2.8	-1.6	-1.7
Alcohol intake frequency.	0.3	0.6	1.0	-1.0	0.9	0.4	0.7
Comparative height size at age 10	0.5	3.0	5.3	-0.8	-2.3	-1.9	1.5
Number of full sisters	0.3	0.4	1.2	0.4	0.2	-0.4	-1.1
Suffer from ‘nerves’	0.1	0.2	0.2	0.4	0.4	-0.4	0.3
Overall health rating	0.4	1.0	2.7	-0.5	1.6	0.5	0.9
Chest pain or discomfort	3.9	5.7	10.7	-2.4	-2.0	1.4	3.3
Had major operations	1.1	1.3	2.0	-1.4	-1.3	0.9	0.8
Age at last live birth	0.8	1.2	4.1	-0.5	0.4	2.0	-0.4
Family relationship satisfaction	1.7	2.0	3.6	-1.0	-1.8	1.9	0.5
Leg pain on walking	0.7	0.8	1.7	0.7	0.9	0.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.3	0.1	-0.6	-0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.1	-1.2	-1.0	0.5	1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	-0.9	-1.3	1.1	0.6
Medication: Aspirin	0.1	0.1	0.2	0.1	0.5	-0.4	-0.4
Supplements: Vitamin C	3.0	3.6	6.2	-2.1	-2.5	1.1	1.6
Knee pain experienced in last month	0.5	0.8	1.6	-1.1	0.3	1.3	0.3
Hypertension (Self-reported)	0.1	0.3	0.8	0.9	0.4	-0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.2	0.9	0.3	-1.5	0.6
Illnesses of father: Heart disease	0.5	0.7	1.3	0.8	0.3	1.1	-0.7
Illnesses of siblings: Diabetes	2.9	3.6	6.8	1.9	2.0	-0.4	-2.6
Smoking status: Previous	1.1	1.7	6.5	-0.3	-2.5	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.7	-0.7	0.2	0.3
Whole body fat-free mass	0.3	1.6	2.9	1.0	1.7	-1.3	0.9
Leg fat-free mass (right)	0.3	1.8	3.2	1.0	1.8	-1.0	1.4
Arm fat percentage (left)	0.5	2.0	7.4	0.8	2.7	-0.1	0.0
Average weekly red wine intake	6.3	9.3	19.8	-2.9	-4.5	1.4	2.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	-0.3	-0.6	0.2	1.4
Mood swings	0.2	0.4	1.1	0.3	-0.2	1.0	0.6
Loneliness, isolation	0.5	0.7	2.2	-0.3	-0.5	0.6	1.5
Long-standing illness, disability or infirmity	0.4	0.5	1.7	-1.3	-0.5	-0.5	-0.1
Ever had bowel cancer screening	0.6	0.7	2.4	-0.4	-1.6	0.1	-0.1
Diabetes diagnosed by doctor	1.0	1.7	3.2	1.4	1.2	-1.8	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.6	-0.6	-1.9	0.0	0.9
Friendships satisfaction	2.0	2.4	3.5	-1.9	-1.2	1.7	1.4
Qualifications: nursing, teaching	1.0	1.5	3.5	-0.8	-1.4	0.3	1.9
Commuting to job workplace: Walk	1.8	2.0	4.8	1.4	1.1	-0.4	-2.2
Eye problems/disorders: Cataract	0.6	0.7	2.5	-0.3	-1.6	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.0	1.3	0.8	0.4	-2.0
Medication for cholesterol	0.6	1.0	1.5	-1.2	-1.0	0.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.1	-1.2	-1.4	0.2	1.4
Back pain experienced in last month	0.8	1.2	2.2	-1.0	0.5	-1.1	1.5
Mineral and other dietary supplements	0.9	1.2	2.6	1.6	1.1	-0.9	-0.6
Breast cancer (self-reported)	0.7	0.8	1.7	1.3	0.5	0.1	-1.1
Asthma (self-reported)	5.8	11.6	21.5	-4.6	-3.2	2.9	2.6
Osteoporosis (self-reported)	2.4	2.9	8.5	-1.1	-1.4	2.9	-0.1
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.5	-0.9	0.2	-0.0
Medication: Aspirin	0.1	0.1	0.2	0.0	0.4	-0.3	-0.3
Medication: Gliclazide	0.2	0.2	0.3	0.1	0.3	-0.5	0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	-1.1	-0.1	-0.7	0.0
Smoking status: Current	1.9	3.0	5.9	2.1	0.9	-2.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	6.7	2.2	2.1	-2.6	-1.0
Whole body water mass	0.3	1.6	3.2	1.0	1.8	-1.2	0.9
Leg predicted mass (right)	0.3	1.8	3.2	1.1	1.8	-1.0	1.4
Arm fat mass (left)	0.6	2.4	8.6	0.9	2.9	-0.4	0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.4	-0.5	-0.4	-0.1
Average weekly champagne plus white wine intake	2.1	2.8	8.0	-1.4	-2.8	0.8	0.8
Miserableness	0.4	0.8	1.0	-0.7	-1.0	-0.9	0.9
Guilty feelings	0.9	1.3	1.9	-1.3	-1.4	0.5	1.2
Wears glasses or contact lenses	0.4	0.4	0.7	-0.6	-0.7	0.8	-0.5
Ever taken oral contraceptive pill	0.8	0.9	2.4	0.0	-0.0	1.5	1.0
Hearing aid user	0.6	0.7	1.8	-0.1	-1.3	-0.7	-0.7
Mother’s age at death	0.4	0.5	1.3	-0.7	-1.1	0.4	0.2
Financial situation satisfaction	0.4	0.5	1.0	0.5	1.0	-0.8	0.2
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.1	-0.0	-2.0	-0.3	1.2
Commuting to job workplace: Public transport	0.1	0.2	0.4	-0.3	-0.3	0.6	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.1	-0.7	-1.4	0.2	-0.0
Medication: Blood pressure	0.3	0.5	1.7	0.1	0.1	1.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.5	-0.9	-1.2	-0.2	1.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.6	-0.7	0.3	0.4
High cholesterol (Self-reported)	0.3	0.6	1.0	0.4	1.0	0.5	-1.0
Medication: Bendroflumethiazide	0.5	0.8	2.3	0.9	0.1	0.3	-1.5
Medication: Paracetamol	2.3	3.6	7.7	-2.8	-2.1	1.2	0.9
Medication: Lisinopril	0.2	0.3	0.8	-0.6	-0.3	-0.9	-0.1
Medication: Atorvastatin	1.5	1.8	5.4	-1.2	-0.3	2.3	0.7
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.3	-0.2	0.9	-0.8
Alcohol drinker status: Never	0.3	0.4	1.1	0.0	1.1	0.4	-0.3
Ever smoked	1.1	1.9	5.2	0.8	-2.3	-0.0	-1.3
Basal metabolic rate	0.3	1.8	4.1	1.1	2.0	-1.1	0.8
Leg fat percentage (left)	0.7	2.5	7.2	1.4	2.7	-0.5	-0.8
Arm fat-free mass (left)	0.5	2.3	6.4	1.2	2.5	-1.2	0.6
Number of operations (self-reported)	1.5	2.2	7.5	-1.0	-2.7	0.1	0.7
Average weekly beer plus cider intake	1.9	2.7	4.8	1.7	2.2	-0.8	-1.7
Irritability	3.5	5.9	8.2	-2.5	-2.9	2.1	2.2
Risk taking	1.4	2.0	5.8	-0.8	-1.1	-0.7	2.4
Ever had prostate specific antigen (PSA) test	3.9	4.5	13.0	-1.4	-3.6	1.2	1.1
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.3	0.3	0.2	0.2
Age started oral contraceptive pill	0.4	0.6	1.3	0.5	-0.3	0.8	-1.1
Diastolic blood pressure, automated reading	1.9	5.8	6.8	2.3	2.6	-2.2	-2.6
Ever depressed for a whole week	0.9	1.2	2.3	0.7	-1.5	0.0	-1.3
Unable to work because of sickness or disability	1.2	1.6	3.6	1.3	1.1	-1.9	0.4
Commuting to job workplace: Cycle	0.5	0.7	1.6	-0.6	-1.3	0.8	-0.2
Myopia	2.0	2.9	6.8	-1.3	-2.6	1.7	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	-0.8	-0.9	-0.1	0.7
Cholesterol lowering medication	0.1	0.1	0.2	0.2	-0.1	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	0.1	-0.9	-0.7	0.7
Pain experienced in last month	0.2	0.4	0.8	0.7	-0.9	0.1	-0.5
Supplements: Calcium	0.9	1.0	2.2	-0.6	-0.9	1.5	0.9
Basal cell carcinoma (self-reported)	2.0	2.3	6.6	-1.3	-1.1	-0.0	2.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.4	-0.4	1.5	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.2	-0.1	-0.8	-0.7
Heart disease (siblings)	0.2	0.2	0.5	-0.5	-0.1	0.1	-0.7
Alcohol drinker status: Previous	1.9	2.1	4.8	-1.2	-1.2	2.2	0.9
Pack years of smoking	0.4	0.6	2.3	0.2	1.5	-0.0	0.2
Impedance of whole body	0.6	2.8	7.3	-1.9	-2.7	0.5	0.1
Leg fat mass (left)	0.7	2.9	8.6	1.5	2.9	-0.8	-0.1
Arm predicted mass (left)	0.4	2.0	5.0	1.1	2.2	-1.2	0.6