Hub : Genes

SCML4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0790 0.0230 2.5e-06 0.027 0.050 0.065 0.050 0.063 2.5e-04 9.9e-07 2.3e-08 9.6e-07 3.7e-08
2 ROSMAP Brain Pre-frontal Cortex 0.0846 0.0247 5.0e-06 0.016 0.046 0.024 0.044 0.035 2.9e-03 1.4e-06 3.5e-04 2.4e-06 2.5e-05
3 YFS Blood 0.2733 0.0334 0.0e+00 0.118 0.246 0.255 0.248 0.260 1.5e-36 1.2e-79 8.3e-83 3.3e-80 1.4e-84
4 TCGA Liver Hepatocellular Carcinoma 0.0880 0.0460 5.6e-03 0.014 0.025 0.065 NA 0.067 7.1e-02 2.5e-02 5.6e-04 NA 4.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.8 0.4 -0.2 -0.9 -0.5
Bipolar Disorder or Schizophrenia 0.5 1.3 4.8 0.7 0.2 -2.2 -0.2
Depressed Affect (Nagel 2018) 1.2 2.6 7.6 -0.9 -1.4 0.3 2.8
Depression (Nagel 2018) 0.6 0.8 1.4 -0.8 -1.2 -1.1 0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.7 -0.1 -0.6 1.1 -1.3
Neuroticism (Nagel 2018) 1.3 3.1 7.0 -1.0 -1.8 -1.2 2.6
Schizophrenia (2018) 0.6 1.3 4.4 0.6 0.6 -2.1 0.1
Schizophrenia vs Biploar Disorder 4.5 5.9 9.8 3.1 1.3 -2.4 -2.5
Worry (Nagel 2018) 0.9 1.9 3.6 -0.7 -0.8 -1.9 1.7
Alzheimer’s Disease (in mother) 0.4 0.5 1.5 -0.2 0.3 1.2 -0.5
Alzheimer’s Disease (in father) 0.6 0.7 1.3 -1.1 -0.8 -0.3 0.8
Alzheimer’s Disease (including proxy) 0.8 1.2 3.3 -0.9 -0.8 1.8 0.2
Crohns Disease (2017) 0.1 0.2 0.4 -0.7 -0.5 -0.4 -0.1
Irritable Bowel Disease (IBD) 0.3 0.6 1.2 -0.6 -0.5 -1.1 0.8
Ulcerative Colitis (UC) 0.3 0.6 1.3 -0.7 -0.6 -0.6 1.1
Major Depression (MDD) 1.1 1.3 4.0 -1.0 -2.0 0.4 0.5
Reaction Time 1.6 3.1 4.9 1.6 2.2 -1.2 -1.9
Verbal and Numeric Reasoning (VNR) 1.6 3.8 11.5 -1.1 -1.5 3.4 -0.3
Breast Cancer 0.3 0.7 1.3 -0.1 1.1 1.1 -0.3
Ovarian Cancer 0.8 1.1 4.0 -0.4 0.2 -0.5 2.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 0.9 2.1 -1.1 -1.5 0.5 0.4
Bipolar Disorder (2011) 0.4 0.4 0.8 -0.6 -0.9 0.4 0.4
Body Mass Index (BMI) (2010) 0.8 1.1 1.6 0.9 1.3 0.5 -1.3
Coronary Artery Disease (CAD) 0.3 0.4 0.9 -0.5 0.9 0.6 0.1
Crohns Disease (2012) 0.1 0.2 0.5 -0.7 -0.5 0.0 0.2
Mean Putamen Volume 1.9 2.2 4.9 1.4 0.9 -2.2 -1.0
Fasting Glucose 0.2 0.3 0.5 0.7 -0.3 -0.6 -0.4
HbA1C 0.5 0.6 1.5 0.5 0.5 -0.7 -1.2
HDL Cholesterol 0.2 0.4 1.1 0.3 0.3 -1.0 -0.5
LDL Cholesterol 0.5 0.8 1.2 1.0 1.0 -1.1 -0.1
Lupus 0.4 0.7 1.5 -0.8 -1.2 0.7 0.3
Neuroticism (2016) 0.7 1.0 2.2 -1.5 -0.5 0.4 1.1
Primary Biliary Cirrhosis 0.0 0.0 0.1 0.3 -0.3 -0.1 -0.1
Rheumatoid Arthritis 0.5 0.7 2.6 0.1 -0.3 1.6 -0.2
Schizophrenia (2014) 1.7 3.7 8.8 1.3 1.4 -3.0 -1.5
Triglycerides 0.2 0.3 0.9 -0.3 0.2 -0.3 0.9
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.4 0.4 -1.2 -0.0 -0.3
Ulcerative Colitis 0.5 0.8 2.7 -0.0 0.5 0.2 1.7
Blood Eosinophil Count 0.7 5.1 7.7 -2.3 -0.9 2.8 2.5
Blood Platelet Count 0.1 1.2 1.8 -0.5 -1.2 1.2 -1.4
Blood Red Count 0.0 0.3 0.7 0.0 0.9 -0.3 -0.5
Blood White Count 2.2 16.1 25.2 4.9 5.0 -2.9 -2.6
Heel T-Score 0.2 1.2 2.2 -1.5 1.1 0.7 0.9
BMI 0.9 5.1 17.1 1.7 4.1 -0.0 -0.5
Height 0.5 8.9 20.2 -2.4 -4.5 -1.1 2.9
Waist Hip Ratio (WHR) 1.0 4.7 12.5 -2.5 -3.5 0.1 0.1
Systolic Blood Pressure 2.0 10.0 19.7 3.2 2.1 -2.3 -4.4
Smoking Status 1.0 2.3 3.7 1.7 -0.5 -1.9 -1.5
Allergy or Eczema 7.7 20.2 26.7 -5.2 -5.0 4.4 3.0
Cardiovascular Disease 0.1 0.2 0.3 0.3 0.5 0.5 -0.4
Hypothyroidism (self reported) 0.4 1.0 2.2 -0.9 -0.9 1.5 -0.2
Respiratory disease 5.8 13.0 23.8 -4.9 -3.6 3.2 2.3
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.9 0.6 0.7 -1.4 0.7
Lung FEV1/FVC ratio 0.6 2.9 6.9 2.6 0.8 -1.6 -1.3
Lung FVC 0.7 3.7 6.5 1.6 2.3 -2.5 -0.4
Neuroticism 0.6 1.5 5.2 -0.7 -0.1 -0.4 2.3
Chronotype (morning person) 0.4 1.0 2.2 -1.1 1.5 0.7 -0.3
Hair Pigment 0.0 1.4 2.7 1.6 1.1 1.1 -0.8
Tanning 0.0 0.5 2.0 0.0 0.0 -1.4 0.3
Hand grip strength (left) 0.6 1.5 3.5 1.6 1.9 0.1 0.3
Number of treatments/medications taken 0.2 0.4 1.5 -0.1 0.2 0.4 -1.2
Average weekly spirits intake 0.4 0.4 1.3 0.1 -0.6 0.4 -1.1
Sensitivity / hurt feelings 0.2 0.3 0.8 -0.5 0.4 0.1 0.9
Frequency of depressed mood in last 2 weeks 1.2 1.7 3.3 -1.8 -1.5 0.1 1.2
Hearing difficulty/problems: Yes 2.2 3.4 10.8 -0.1 -3.3 -1.5 0.8
Relative age of first facial hair 0.8 1.7 5.6 -1.1 -2.4 -0.0 0.1
Other serious medical condition/disability diagnosed by doctor 3.0 3.9 7.8 -2.8 -2.5 0.5 1.1
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.5 -0.0 -0.2 -0.5
Ever had hysterectomy (womb removed) 0.7 0.8 1.9 -0.9 -1.4 -0.7 -0.4
Systolic blood pressure, automated reading 2.6 7.6 9.7 2.6 2.0 -3.1 -3.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.8 0.9 0.8 -0.2 -0.8
Angina 0.1 0.1 0.2 -0.4 -0.2 0.4 0.1
Medication for hormone replacement therapy 3.2 3.6 5.8 2.4 1.2 -2.3 -1.4
Vitamin and mineral supplements 1.0 1.4 3.3 1.2 0.8 -0.0 -1.8
Supplements: Zinc 1.1 1.2 1.7 -0.6 -1.3 -1.2 1.2
Medication: Co-codamol 0.7 0.8 3.1 -1.8 -0.0 0.1 -0.1
Medication: Metformin 0.5 0.8 2.3 0.5 0.5 -1.5 0.6
Diabetes (father) 1.3 1.7 3.1 1.3 1.8 -0.4 -1.3
Diabetes (mother) 1.2 1.5 5.3 0.9 -0.1 -2.3 0.1
Severe depression (siblings) 1.5 1.7 5.3 1.0 0.1 -2.3 -0.6
Pack years adult smoking proportion 0.6 0.9 3.1 0.6 1.8 -0.6 0.0
Impedance of leg (right) 0.3 1.3 2.0 -0.9 -1.3 0.7 -1.4
Leg fat-free mass (left) 0.4 2.3 4.8 1.3 2.2 -1.0 1.2
Trunk fat percentage 0.5 2.2 6.9 1.2 2.6 -0.6 -0.2
Hand grip strength (right) 0.8 2.1 4.5 1.6 2.1 -1.1 0.2
Townsend deprivation index at recruitment 4.6 6.4 7.2 2.5 2.7 -2.4 -2.5
Current tobacco smoking 2.2 3.6 7.0 2.2 1.0 -2.6 -1.2
Average weekly fortified wine intake 0.9 1.0 2.6 -0.7 -1.6 0.4 0.9
Maternal smoking around birth 1.1 1.6 5.6 -0.2 -0.7 0.2 2.4
Fed-up feelings 1.3 2.3 7.0 -1.0 -0.7 0.8 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.0 -0.8 -0.5 -0.8 1.0
Relative age voice broke 0.7 1.1 3.7 -0.5 -1.9 -0.1 -0.7
Taking other prescription medications 0.2 0.4 1.0 -1.0 -0.5 0.0 -0.5
Age when periods started (menarche) 0.1 0.1 0.3 0.5 -0.5 -0.1 -0.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.1 -0.2 -0.8 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 6.2 -2.5 -0.4 1.9 2.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.0 1.0 0.9 -0.4 -0.5
Qualifications: CSEs or equivalent 0.4 0.6 1.1 -1.0 0.8 -0.1 0.7
Serious illness, injury or assault to yourself 0.4 0.4 0.9 -0.3 -0.5 -1.0 0.7
High blood pressure 0.2 0.5 1.0 1.0 0.5 0.1 -0.8
Hayfever, allergic rhinitis or eczema 6.6 14.4 19.6 -4.4 -4.3 3.7 2.4
Multivitamins +/- minerals 0.3 0.4 1.4 -0.4 0.2 0.1 1.2
Stomach or abdominal pain in last month 2.7 3.4 6.5 2.5 1.2 -1.7 -1.7
Supplements: Glucosamine 0.3 0.4 0.8 -0.6 -0.8 0.9 0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 1.1 0.4 -0.8 -0.3
Medication: Atenolol 0.1 0.2 0.3 -0.5 -0.6 -0.2 0.1
Medication: Levothyroxine sodium 0.6 1.1 2.7 -1.1 -1.6 0.1 0.6
Sitting height 0.2 1.2 4.1 0.3 0.1 -2.0 0.8
Chronic bronchitis/emphysema (father) 3.1 3.7 7.8 -1.8 -2.8 0.1 1.9
High blood pressure (mother) 0.7 1.0 1.7 1.3 0.3 -1.0 -1.2
Body mass index (BMI) 1.3 5.7 17.4 2.1 4.2 -0.8 -0.7
Impedance of leg (left) 0.3 1.5 3.1 -1.1 -1.8 0.6 -1.1
Leg predicted mass (left) 0.4 2.3 5.0 1.4 2.2 -1.0 1.2
Trunk fat mass 0.5 2.1 6.2 1.2 2.5 -0.8 0.2
Waist circumference 0.4 1.3 3.7 0.9 1.9 -0.8 -0.5
Number of incorrect matches in round 0.9 1.5 3.0 -0.5 -1.5 -1.7 0.6
Past tobacco smoking 1.1 2.0 7.1 -0.2 2.7 -0.5 0.8
Alcohol usually taken with meals 0.8 1.3 2.4 -0.6 -1.5 -0.4 1.6
Nervous feelings 0.2 0.4 1.3 -0.5 0.0 -1.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.5 5.9 -2.3 -1.6 -0.0 2.4
Hearing difficulty/problems with background noise 3.1 5.0 11.0 -2.5 -3.3 0.7 1.5
Hair/balding pattern: Pattern 2 1.6 2.0 4.3 -2.1 -0.5 1.5 1.1
Had menopause 0.8 1.1 1.9 0.3 -1.3 -1.4 0.7
Had other major operations 0.9 1.1 3.0 -0.9 -1.7 -0.4 0.7
Forced vital capacity (FVC) 0.5 2.0 7.3 0.6 0.0 -2.7 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.2 -0.9 0.9 1.8 1.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 0.5 -0.6 -0.5 -0.7
Qualifications: None of the above 0.3 0.7 1.2 1.1 0.9 -0.2 -0.9
Financial difficulties in last 2 years 0.7 0.9 2.0 0.2 1.3 -1.4 0.0
Mouth/teeth dental problems 2.7 4.1 7.2 -1.9 -1.6 1.8 2.7
Heart attack 0.5 0.6 2.3 -0.4 1.5 -0.0 0.2
Allergy 7.3 16.9 27.2 5.2 4.5 -3.7 -2.6
Pain all over the body in last month 0.3 0.3 0.9 -0.9 -0.5 0.3 0.3
Diabetes (self-reported) 0.7 1.0 2.2 -0.0 0.4 -1.5 1.3
Hayfever/allergic rhinitis (self-reported) 7.2 9.5 16.2 -4.0 -3.3 2.8 1.8
Medication: Ramipril 0.1 0.2 0.4 0.5 0.0 -0.6 0.3
Medication: Simvastatin 0.2 0.2 0.5 0.5 0.5 -0.7 0.2
Fluid intelligence score 1.1 2.4 5.4 -1.1 -1.7 2.3 0.1
Illnesses of siblings 1.9 2.6 4.1 -1.5 -1.0 2.0 1.8
Neuroticism score 0.6 1.2 3.9 -0.7 -0.5 -0.0 2.0
Weight 0.5 2.2 7.0 1.1 2.6 -0.9 0.3
Impedance of arm (right) 0.9 4.1 10.2 -2.2 -3.2 0.8 0.9
Arm fat percentage (right) 0.5 1.8 6.5 0.8 2.5 -0.2 0.0
Trunk fat-free mass 0.2 0.9 1.6 0.7 1.1 -1.3 0.8
Hip circumference 1.0 4.3 11.5 2.0 3.4 -1.3 -0.4
Time employed in main current job 0.3 0.4 1.3 0.2 0.1 -1.1 0.5
Alcohol intake versus 10 years previously 0.4 0.6 2.0 0.7 1.4 -0.2 0.0
Father’s age at death 2.3 3.1 6.0 2.5 1.0 -0.8 -2.1
Worrier / anxious feelings 0.9 1.6 2.6 -1.6 -1.1 -0.2 1.6
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 4.9 -2.2 -0.6 0.8 2.1
Falls in the last year 1.6 2.1 4.8 -1.4 -1.2 0.7 2.2
Hair/balding pattern: Pattern 3 2.1 3.1 5.6 1.5 1.0 -1.9 -2.4
Number of live births 0.7 1.0 2.2 0.9 1.5 -0.9 -0.4
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 7.7 1.4 0.7 -2.8 0.2
Pulse rate 0.8 1.3 3.2 1.8 1.2 -0.7 -0.3
Happiness 0.1 0.1 0.5 0.7 0.3 0.0 -0.1
Noisy workplace 0.3 0.4 1.0 0.6 1.0 0.0 0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.3 -0.5 -0.2 0.6 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.0 0.9 0.4 -0.2 -1.0
Mouth/teeth dental problems: Dentures 1.0 1.7 3.4 0.7 1.8 -1.0 -1.4
Asthma 5.6 11.1 21.6 -4.6 -3.1 2.5 2.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.6 -0.5 -1.0 1.3 0.9
Medication: Cholesterol lowering 0.3 0.5 1.6 0.3 1.2 0.4 -0.4
Depression (self-reported) 0.9 1.0 1.7 1.3 1.3 -0.5 -0.7
Medication: Lansoprazole 0.9 1.0 2.0 1.4 0.6 -1.2 -0.4
Prospective memory result 0.0 0.0 0.0 -0.2 0.1 0.1 -0.2
Lung cancer (father) 0.5 0.6 1.8 0.7 0.3 -1.3 -0.3
Illnesses of mother 0.8 0.9 1.9 -1.4 -0.0 0.5 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 8.5 1.5 1.3 -2.9 0.3
Pulse wave Arterial Stiffness index 3.3 3.8 5.3 2.3 2.0 -2.0 -1.4
Impedance of arm (left) 0.9 4.2 10.0 -2.3 -3.2 0.9 0.8
Arm fat mass (right) 0.6 2.4 8.3 1.0 2.9 -0.6 0.1
Trunk predicted mass 0.2 0.9 1.5 0.6 1.0 -1.2 0.9
Standing height 0.4 4.4 8.6 -1.8 -2.9 -0.7 2.3
Length of working week for main job 0.4 0.4 1.5 -0.1 1.2 0.0 -0.3
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.2 -0.4 -0.6 -0.5
Breastfed as a baby 0.2 0.3 0.6 -0.8 -0.2 0.7 -0.2
Tense / ‘highly strung’ 0.7 1.2 3.4 -0.4 -0.5 -1.8 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.2 8.0 -0.6 -2.8 0.2 0.7
Hair/balding pattern: Pattern 4 0.4 1.1 3.6 0.3 -0.7 1.9 -0.0
Birth weight of first child 0.8 1.4 2.2 -1.2 -1.5 0.4 1.4
Peak expiratory flow (PEF) 0.4 0.9 1.4 1.2 0.9 -1.2 -0.5
Pulse wave reflection index 0.6 0.7 1.0 0.8 1.0 0.2 -1.0
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 -0.3 -1.1 1.1 0.4
Loud music exposure frequency 0.3 0.3 0.8 -0.6 0.2 0.9 0.4
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 2.4 1.4 1.5 -1.5 -1.5
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 1.5 1.0 0.7 -1.2 -0.9
Blood clot in the leg (DVT) 0.2 0.2 0.5 0.2 0.0 -0.6 -0.7
Medication: Paracetamol 1.1 1.8 3.6 -1.9 -1.6 1.0 0.4
Headache pain in last month 0.3 0.5 1.7 -0.2 0.4 -1.3 0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.0 -0.4 -0.6 0.4
Glaucoma (self-reported) 0.4 0.5 1.0 0.3 -1.0 -0.3 -0.9
Gout (self-reported) 6.3 8.7 11.4 -2.8 -2.4 3.4 3.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 1.7 -1.2 -1.3 1.1 0.7
Medication: Amlodipine 0.7 1.0 1.4 0.9 1.2 0.8 -1.0
Medication: Ventolin 100micrograms inhaler 5.3 6.8 14.3 -3.8 -1.1 3.0 1.6
Birth weight 0.6 1.4 2.2 -1.3 -0.9 1.5 0.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 0.6 0.4 -0.1 0.1
High blood pressure (siblings) 0.6 0.8 2.4 0.6 0.0 -1.5 -0.8
Forced vital capacity (FVC), Best measure 0.5 1.7 5.9 0.7 0.1 -2.4 0.7
Body fat percentage 0.7 2.6 8.4 1.2 2.9 -0.6 -0.4
Leg fat percentage (right) 0.9 3.4 9.5 1.7 3.1 -0.4 -1.1
Arm fat-free mass (right) 0.5 2.4 6.1 1.4 2.5 -1.2 0.3
Exposure to tobacco smoke outside home 1.0 1.4 3.9 -0.6 -0.6 -0.9 2.0
Comparative body size at age 10 0.1 0.3 0.5 -0.3 0.6 -0.1 0.7
Number of full brothers 0.3 0.4 0.7 0.5 -0.0 -0.9 0.8
Worry too long after embarrassment 0.2 0.3 0.5 0.7 -0.1 -0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 6.7 -1.0 -2.6 0.9 0.9
Wheeze or whistling in the chest in last year 1.2 2.2 3.0 -1.7 -1.6 1.7 0.2
Number of children fathered 0.2 0.2 0.4 -0.2 -0.6 -0.5 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 -0.9 -1.0 0.3 -0.1
Age at first live birth 1.5 2.7 6.2 -1.7 -1.0 2.5 0.9
Pulse wave peak to peak time 3.6 4.3 6.0 -2.4 -2.3 1.9 1.6
Health satisfaction 1.0 1.2 2.4 -1.3 -0.0 0.9 1.6
Shortness of breath walking on level ground 0.8 1.0 2.2 -1.5 -0.2 1.2 0.3
Qualifications: College or University degree 1.5 4.7 4.9 -2.2 -2.1 2.2 2.2
Eye problems/disorders: None of the above 0.7 0.8 1.5 -0.8 1.1 -0.1 1.2
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 0.5 -0.7 -0.5 -0.9
Emphysema/chronic bronchitis 6.5 7.3 10.6 -3.3 -2.7 3.1 1.3
Medication for pain relief, constipation, heartburn 0.5 0.9 2.3 1.5 0.6 0.7 -0.6
Neck or shoulder pain in last month 0.6 0.9 2.6 -1.6 -0.4 -0.5 0.7
Medication: Blood pressure 0.2 0.3 0.5 0.5 0.4 -0.5 -0.7
Angina (self-reported) 0.0 0.0 0.1 0.2 0.2 0.1 -0.3
Migraine (self-reported) 0.1 0.1 0.1 0.4 -0.3 -0.0 -0.1
Medication: Ibuprofen 1.3 1.5 2.5 -1.1 -1.2 1.6 1.0
Medication: Allopurinol 2.5 3.4 5.9 -1.6 -1.6 1.6 2.4
Medication: Omeprazole 0.2 0.3 1.0 -0.1 -1.0 -0.1 0.3
Medication: Seretide 50 evohaler 4.0 4.6 7.9 -2.8 -1.6 1.7 2.3
Mean time to correctly identify matches 2.1 4.1 8.6 1.9 1.7 -1.1 -2.9
Heart disease (mother) 0.3 0.4 0.7 0.2 -0.5 0.8 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 4.6 2.1 0.8 -2.0 -1.9
Whole body fat mass 0.7 3.0 8.8 1.4 3.0 -1.0 -0.1
Leg fat mass (right) 0.9 3.4 10.3 1.6 3.2 -0.7 -0.3
Arm predicted mass (right) 0.5 2.5 6.3 1.2 2.5 -1.3 0.5
Pulse rate, automated reading 1.8 5.9 10.3 3.2 2.8 -1.6 -1.7
Alcohol intake frequency. 0.3 0.6 1.0 -1.0 0.9 0.4 0.7
Comparative height size at age 10 0.5 3.0 5.3 -0.8 -2.3 -1.9 1.5
Number of full sisters 0.3 0.4 1.2 0.4 0.2 -0.4 -1.1
Suffer from ‘nerves’ 0.1 0.2 0.2 0.4 0.4 -0.4 0.3
Overall health rating 0.4 1.0 2.7 -0.5 1.6 0.5 0.9
Chest pain or discomfort 3.9 5.7 10.7 -2.4 -2.0 1.4 3.3
Had major operations 1.1 1.3 2.0 -1.4 -1.3 0.9 0.8
Age at last live birth 0.8 1.2 4.1 -0.5 0.4 2.0 -0.4
Family relationship satisfaction 1.7 2.0 3.6 -1.0 -1.8 1.9 0.5
Leg pain on walking 0.7 0.8 1.7 0.7 0.9 0.5 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.3 0.1 -0.6 -0.3
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.1 -1.2 -1.0 0.5 1.5
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.7 -0.9 -1.3 1.1 0.6
Medication: Aspirin 0.1 0.1 0.2 0.1 0.5 -0.4 -0.4
Supplements: Vitamin C 3.0 3.6 6.2 -2.1 -2.5 1.1 1.6
Knee pain experienced in last month 0.5 0.8 1.6 -1.1 0.3 1.3 0.3
Hypertension (Self-reported) 0.1 0.3 0.8 0.9 0.4 -0.2 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.2 0.9 0.3 -1.5 0.6
Illnesses of father: Heart disease 0.5 0.7 1.3 0.8 0.3 1.1 -0.7
Illnesses of siblings: Diabetes 2.9 3.6 6.8 1.9 2.0 -0.4 -2.6
Smoking status: Previous 1.1 1.7 6.5 -0.3 -2.5 0.1 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.5 -0.7 -0.7 0.2 0.3
Whole body fat-free mass 0.3 1.6 2.9 1.0 1.7 -1.3 0.9
Leg fat-free mass (right) 0.3 1.8 3.2 1.0 1.8 -1.0 1.4
Arm fat percentage (left) 0.5 2.0 7.4 0.8 2.7 -0.1 0.0
Average weekly red wine intake 6.3 9.3 19.8 -2.9 -4.5 1.4 2.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.1 -0.3 -0.6 0.2 1.4
Mood swings 0.2 0.4 1.1 0.3 -0.2 1.0 0.6
Loneliness, isolation 0.5 0.7 2.2 -0.3 -0.5 0.6 1.5
Long-standing illness, disability or infirmity 0.4 0.5 1.7 -1.3 -0.5 -0.5 -0.1
Ever had bowel cancer screening 0.6 0.7 2.4 -0.4 -1.6 0.1 -0.1
Diabetes diagnosed by doctor 1.0 1.7 3.2 1.4 1.2 -1.8 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.6 -0.6 -1.9 0.0 0.9
Friendships satisfaction 2.0 2.4 3.5 -1.9 -1.2 1.7 1.4
Qualifications: nursing, teaching 1.0 1.5 3.5 -0.8 -1.4 0.3 1.9
Commuting to job workplace: Walk 1.8 2.0 4.8 1.4 1.1 -0.4 -2.2
Eye problems/disorders: Cataract 0.6 0.7 2.5 -0.3 -1.6 0.3 0.2
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.0 1.3 0.8 0.4 -2.0
Medication for cholesterol 0.6 1.0 1.5 -1.2 -1.0 0.5 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.1 -1.2 -1.4 0.2 1.4
Back pain experienced in last month 0.8 1.2 2.2 -1.0 0.5 -1.1 1.5
Mineral and other dietary supplements 0.9 1.2 2.6 1.6 1.1 -0.9 -0.6
Breast cancer (self-reported) 0.7 0.8 1.7 1.3 0.5 0.1 -1.1
Asthma (self-reported) 5.8 11.6 21.5 -4.6 -3.2 2.9 2.6
Osteoporosis (self-reported) 2.4 2.9 8.5 -1.1 -1.4 2.9 -0.1
Osteoarthritis (self-reported) 0.2 0.3 0.7 -0.5 -0.9 0.2 -0.0
Medication: Aspirin 0.1 0.1 0.2 0.0 0.4 -0.3 -0.3
Medication: Gliclazide 0.2 0.2 0.3 0.1 0.3 -0.5 0.6
Illnesses of father: None of the above (group 1) 0.3 0.4 1.1 -1.1 -0.1 -0.7 0.0
Smoking status: Current 1.9 3.0 5.9 2.1 0.9 -2.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.3 6.7 2.2 2.1 -2.6 -1.0
Whole body water mass 0.3 1.6 3.2 1.0 1.8 -1.2 0.9
Leg predicted mass (right) 0.3 1.8 3.2 1.1 1.8 -1.0 1.4
Arm fat mass (left) 0.6 2.4 8.6 0.9 2.9 -0.4 0.2
Number of self-reported non-cancer illnesses 0.1 0.1 0.2 -0.4 -0.5 -0.4 -0.1
Average weekly champagne plus white wine intake 2.1 2.8 8.0 -1.4 -2.8 0.8 0.8
Miserableness 0.4 0.8 1.0 -0.7 -1.0 -0.9 0.9
Guilty feelings 0.9 1.3 1.9 -1.3 -1.4 0.5 1.2
Wears glasses or contact lenses 0.4 0.4 0.7 -0.6 -0.7 0.8 -0.5
Ever taken oral contraceptive pill 0.8 0.9 2.4 0.0 -0.0 1.5 1.0
Hearing aid user 0.6 0.7 1.8 -0.1 -1.3 -0.7 -0.7
Mother’s age at death 0.4 0.5 1.3 -0.7 -1.1 0.4 0.2
Financial situation satisfaction 0.4 0.5 1.0 0.5 1.0 -0.8 0.2
Tinnitus: Yes, now most or all of the time 1.2 1.4 4.1 -0.0 -2.0 -0.3 1.2
Commuting to job workplace: Public transport 0.1 0.2 0.4 -0.3 -0.3 0.6 -0.3
Eye problems/disorders: Glaucoma 0.6 0.7 2.1 -0.7 -1.4 0.2 -0.0
Medication: Blood pressure 0.3 0.5 1.7 0.1 0.1 1.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.5 -0.9 -1.2 -0.2 1.0
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.5 -0.6 -0.7 0.3 0.4
High cholesterol (Self-reported) 0.3 0.6 1.0 0.4 1.0 0.5 -1.0
Medication: Bendroflumethiazide 0.5 0.8 2.3 0.9 0.1 0.3 -1.5
Medication: Paracetamol 2.3 3.6 7.7 -2.8 -2.1 1.2 0.9
Medication: Lisinopril 0.2 0.3 0.8 -0.6 -0.3 -0.9 -0.1
Medication: Atorvastatin 1.5 1.8 5.4 -1.2 -0.3 2.3 0.7
Illnesses of father: High blood pressure 0.3 0.4 0.7 0.3 -0.2 0.9 -0.8
Alcohol drinker status: Never 0.3 0.4 1.1 0.0 1.1 0.4 -0.3
Ever smoked 1.1 1.9 5.2 0.8 -2.3 -0.0 -1.3
Basal metabolic rate 0.3 1.8 4.1 1.1 2.0 -1.1 0.8
Leg fat percentage (left) 0.7 2.5 7.2 1.4 2.7 -0.5 -0.8
Arm fat-free mass (left) 0.5 2.3 6.4 1.2 2.5 -1.2 0.6
Number of operations (self-reported) 1.5 2.2 7.5 -1.0 -2.7 0.1 0.7
Average weekly beer plus cider intake 1.9 2.7 4.8 1.7 2.2 -0.8 -1.7
Irritability 3.5 5.9 8.2 -2.5 -2.9 2.1 2.2
Risk taking 1.4 2.0 5.8 -0.8 -1.1 -0.7 2.4
Ever had prostate specific antigen (PSA) test 3.9 4.5 13.0 -1.4 -3.6 1.2 1.1
Fractured/broken bones in last 5 years 0.1 0.1 0.1 0.3 0.3 0.2 0.2
Age started oral contraceptive pill 0.4 0.6 1.3 0.5 -0.3 0.8 -1.1
Diastolic blood pressure, automated reading 1.9 5.8 6.8 2.3 2.6 -2.2 -2.6
Ever depressed for a whole week 0.9 1.2 2.3 0.7 -1.5 0.0 -1.3
Unable to work because of sickness or disability 1.2 1.6 3.6 1.3 1.1 -1.9 0.4
Commuting to job workplace: Cycle 0.5 0.7 1.6 -0.6 -1.3 0.8 -0.2
Myopia 2.0 2.9 6.8 -1.3 -2.6 1.7 0.4
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.8 -0.8 -0.9 -0.1 0.7
Cholesterol lowering medication 0.1 0.1 0.2 0.2 -0.1 -0.5 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.8 0.1 -0.9 -0.7 0.7
Pain experienced in last month 0.2 0.4 0.8 0.7 -0.9 0.1 -0.5
Supplements: Calcium 0.9 1.0 2.2 -0.6 -0.9 1.5 0.9
Basal cell carcinoma (self-reported) 2.0 2.3 6.6 -1.3 -1.1 -0.0 2.6
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.4 -0.4 1.5 -0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.2 -0.1 -0.8 -0.7
Heart disease (siblings) 0.2 0.2 0.5 -0.5 -0.1 0.1 -0.7
Alcohol drinker status: Previous 1.9 2.1 4.8 -1.2 -1.2 2.2 0.9
Pack years of smoking 0.4 0.6 2.3 0.2 1.5 -0.0 0.2
Impedance of whole body 0.6 2.8 7.3 -1.9 -2.7 0.5 0.1
Leg fat mass (left) 0.7 2.9 8.6 1.5 2.9 -0.8 -0.1
Arm predicted mass (left) 0.4 2.0 5.0 1.1 2.2 -1.2 0.6