Hub : Genes

SCN1B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2950	0.1110	8.5e-03	0.002	NA	-0.004	NA	0.013	2.8e-01	NA	4.1e-01	NA	1.4e-01
2	GTEx	Cells Transformed fibroblasts	0.2130	0.0540	3.5e-06	0.095	NA	0.137	NA	0.116	1.4e-07	NA	2.0e-10	NA	5.4e-09
3	YFS	Blood	0.0199	0.0078	2.5e-03	-0.001	0.012	0.000	0.012	0.000	8.3e-01	4.4e-05	2.9e-01	5.9e-05	3.3e-01
4	TCGA	Pancreatic Adenocarcinoma	0.1790	0.0920	6.9e-03	0.097	0.000	0.014	NA	0.057	7.1e-05	3.3e-01	8.0e-02	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	3.7	0.3	0.0	-0.1	-1.9
Bipolar Disorder or Schizophrenia	0.6	1.4	5.2	0.2	-0.1	0.5	-2.3
Depressed Affect (Nagel 2018)	0.4	0.7	1.8	0.2	-1.3	0.1	-1.1
Depression (Nagel 2018)	0.5	0.8	2.6	0.5	-0.4	0.4	-1.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	0.4	-0.5	1.0	-1.0
Neuroticism (Nagel 2018)	0.5	1.1	1.4	-0.8	-1.2	-1.1	-1.1
Schizophrenia (2018)	0.3	0.5	1.6	-0.0	-0.1	0.7	-1.3
Schizophrenia vs Biploar Disorder	1.0	1.4	4.1	-2.0	-1.1	-0.4	0.0
Worry (Nagel 2018)	0.1	0.2	0.6	-0.4	-0.1	-0.8	-0.2
Alzheimer’s Disease (in mother)	2.1	2.4	6.9	-1.6	-2.6	-0.5	-0.3
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.5	0.6	0.6	0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	2.9	-1.7	-1.7	-0.6	0.6
Crohns Disease (2017)	0.6	1.3	2.6	1.2	-0.5	-0.9	1.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	1.5	-0.8	-0.4	0.9
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.9	-0.8	0.5	-0.1
Major Depression (MDD)	1.2	1.5	3.5	0.5	-0.5	1.4	-1.9
Reaction Time	1.5	2.8	4.4	-2.1	-1.8	1.0	-1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	0.4	0.0	1.7	-0.8
Breast Cancer	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4
Ovarian Cancer	1.1	1.5	2.6	1.6	0.7	1.5	-0.8
Prostate Cancer	0.2	0.2	0.8	0.9	0.1	-0.3	0.1
Age at First Birth	0.9	1.4	2.4	1.0	1.5	-0.1	1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	-1.4	-0.1	0.1	1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-1.3	-0.6	-0.5	0.0
Crohns Disease (2012)	0.6	0.9	2.0	0.0	-1.4	-0.6	1.1
Mean Putamen Volume	1.9	2.2	5.9	1.0	0.3	-2.4	1.3
Fasting Glucose	0.5	0.6	1.3	1.1	0.0	0.6	-0.8
HbA1C	0.2	0.2	0.5	-0.7	-0.2	-0.3	-0.5
HDL Cholesterol	2.7	4.4	8.6	-1.3	-2.6	-1.0	-2.9
LDL Cholesterol	0.6	1.0	1.7	1.3	1.2	0.5	0.7
Lupus	0.3	0.4	1.0	1.0	-0.5	0.4	0.6
Neuroticism (2016)	0.2	0.2	0.5	0.2	-0.7	-0.1	-0.6
Primary Biliary Cirrhosis	0.3	0.4	1.4	0.4	1.2	0.2	-0.1
Rheumatoid Arthritis	0.6	0.9	1.8	0.6	0.5	1.0	-1.3
Schizophrenia (2014)	0.3	0.7	1.5	0.4	0.3	1.0	-1.2
Triglycerides	1.0	1.7	4.1	2.0	1.4	0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	-0.8	0.1	-1.2	0.0
Ulcerative Colitis	0.2	0.3	0.6	0.0	-0.8	0.7	-0.3
Blood Eosinophil Count	0.2	1.5	4.5	0.0	-2.1	-1.0	-0.8
Blood Platelet Count	0.1	1.7	4.9	-1.0	-0.8	-2.2	-0.5
Blood Red Count	1.5	14.8	19.4	4.4	3.4	4.4	3.0
Blood White Count	1.0	7.1	21.4	-1.4	-4.6	-0.6	-2.2
Heel T-Score	0.1	1.1	2.6	0.4	1.1	0.7	1.6
BMI	0.4	2.6	4.9	1.7	0.6	1.4	2.2
Height	0.6	11.4	26.3	-0.5	-4.1	-1.4	-5.1
Waist Hip Ratio (WHR)	0.2	1.0	1.3	-1.1	-1.1	-0.8	-1.0
Systolic Blood Pressure	0.1	0.3	0.6	0.3	-0.8	-0.5	0.5
Smoking Status	0.3	0.7	1.8	-0.5	-0.7	0.4	-1.3
Allergy or Eczema	0.9	2.3	5.2	1.5	1.3	2.3	0.5
Cardiovascular Disease	0.2	0.7	2.2	0.1	-1.5	0.6	0.1
Hypothyroidism (self reported)	0.5	1.2	2.4	-1.5	0.3	-1.6	0.0
Respiratory disease	0.5	1.2	2.0	0.9	1.3	1.4	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.7	-0.9	0.5	0.5
Lung FEV1/FVC ratio	0.1	0.4	0.7	-0.5	-0.5	-0.9	0.5
Lung FVC	0.8	4.3	6.7	2.6	2.0	-0.2	-2.6
Neuroticism	0.6	1.5	4.0	-0.7	-1.2	-0.2	-2.0
Chronotype (morning person)	0.6	1.4	3.2	-0.9	-0.7	-1.8	-1.1
Hair Pigment	0.1	2.9	7.7	0.5	0.9	2.8	1.7
Tanning	0.1	1.4	5.1	-0.2	-0.5	0.3	-2.3
Hand grip strength (left)	0.7	1.9	3.5	-1.9	-1.2	-1.3	-0.9
Number of treatments/medications taken	1.1	2.0	4.7	-0.2	-2.2	-1.7	-0.7
Average weekly spirits intake	0.4	0.5	0.8	0.6	0.6	0.7	0.9
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.8	-0.4	-1.1	0.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.6	-0.1	-0.2	0.3	-1.9
Hearing difficulty/problems: Yes	2.1	3.3	7.1	2.7	2.3	0.6	0.3
Relative age of first facial hair	0.3	0.6	1.1	-0.8	0.2	0.8	-1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.2	-1.1	0.5	-0.9	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.6	-0.1	0.2
Ever had hysterectomy (womb removed)	3.3	3.7	9.7	-1.1	-1.9	-0.8	-3.1
Systolic blood pressure, automated reading	0.3	1.0	1.9	1.2	-0.2	0.8	1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	-1.2	-0.8	-0.9	-1.3
Angina	0.7	0.9	1.8	0.3	-0.2	-1.2	-1.3
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	-0.4	0.5	-0.1
Vitamin and mineral supplements	1.3	1.8	3.9	0.8	1.0	1.3	2.0
Supplements: Zinc	0.1	0.1	0.3	0.2	0.1	-0.4	-0.6
Medication: Co-codamol	0.9	1.1	3.2	-0.3	-1.8	0.6	-0.8
Medication: Metformin	0.2	0.3	1.0	-0.2	-1.0	-0.4	0.1
Diabetes (father)	0.2	0.3	0.5	0.5	0.6	-0.7	0.1
Diabetes (mother)	1.2	1.6	3.6	0.4	1.6	-0.1	1.9
Severe depression (siblings)	1.1	1.2	2.7	-1.6	-0.2	0.0	-1.5
Pack years adult smoking proportion	0.6	0.9	2.5	1.6	-0.7	0.9	-0.1
Impedance of leg (right)	0.3	1.7	4.1	-2.0	-1.0	-1.2	-0.5
Leg fat-free mass (left)	0.0	0.2	0.4	0.3	-0.6	0.1	-0.6
Trunk fat percentage	0.2	0.7	1.9	0.1	-1.0	0.2	1.4
Hand grip strength (right)	0.3	0.9	2.4	-1.5	-0.6	-0.9	0.1
Townsend deprivation index at recruitment	0.7	0.9	3.1	0.2	-0.5	0.5	-1.8
Current tobacco smoking	0.6	1.1	1.6	1.3	1.2	1.1	0.1
Average weekly fortified wine intake	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1
Maternal smoking around birth	0.4	0.5	0.9	0.4	0.5	-1.0	1.0
Fed-up feelings	1.0	1.7	3.2	-0.6	-1.8	-0.4	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	4.4	-0.0	-0.8	0.2	-2.1
Relative age voice broke	0.4	0.6	2.1	-0.0	1.5	0.5	0.0
Taking other prescription medications	1.3	1.9	4.0	-1.1	-1.6	-2.0	-0.4
Age when periods started (menarche)	0.7	1.8	6.0	2.5	0.3	1.0	-0.1
Bilateral oophorectomy (both ovaries removed)	3.0	3.4	9.2	-0.4	-1.9	-0.9	-3.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.3	0.6	1.8	0.4	0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-1.2	-0.4	-0.9	0.6
Qualifications: CSEs or equivalent	0.4	0.5	1.7	-1.3	0.2	-0.5	-0.1
Serious illness, injury or assault to yourself	1.1	1.4	2.4	-0.5	-1.5	-0.7	-1.6
High blood pressure	0.3	0.7	2.7	0.0	-1.6	-0.0	-0.5
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.1	1.5	1.1	1.5	0.4
Multivitamins +/- minerals	0.4	0.5	0.8	-0.2	0.6	-0.8	-0.9
Stomach or abdominal pain in last month	0.7	0.9	2.1	-0.5	-1.0	0.5	-1.4
Supplements: Glucosamine	1.2	1.6	3.0	-0.4	-0.8	-1.6	-1.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	4.1	2.0	0.9	0.4	0.9
Medication: Atenolol	2.1	2.6	3.8	1.9	2.0	-1.7	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.9	-1.0	-0.5	-0.4	0.2
Sitting height	0.5	3.8	5.9	-0.6	-2.4	-1.9	-2.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.4	0.5	-1.6	-0.3	0.9
High blood pressure (mother)	0.6	0.8	2.2	0.1	-0.3	-1.0	1.5
Body mass index (BMI)	0.3	1.2	3.1	0.8	0.0	0.9	1.8
Impedance of leg (left)	0.2	0.9	2.5	-1.6	-0.6	-0.8	-0.1
Leg predicted mass (left)	0.0	0.2	0.5	0.2	-0.6	0.1	-0.7
Trunk fat mass	0.1	0.5	1.2	0.2	-0.8	0.1	1.1
Waist circumference	0.1	0.3	0.7	-0.2	-0.8	0.3	0.6
Number of incorrect matches in round	0.3	0.5	0.7	-0.8	-0.8	-0.8	-0.3
Past tobacco smoking	0.8	1.4	2.9	-0.1	1.6	-0.7	1.7
Alcohol usually taken with meals	0.1	0.1	0.2	0.3	0.0	0.5	-0.4
Nervous feelings	0.5	0.9	1.9	-0.6	-0.6	-1.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	-0.1	-0.4	-0.1	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.8	0.4	1.3	-0.6	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.5	-0.0	-1.1	0.3
Had menopause	1.5	1.8	5.0	2.2	1.3	-0.7	0.4
Had other major operations	0.8	1.0	1.4	-0.8	-1.1	-0.9	-1.2
Forced vital capacity (FVC)	0.2	0.7	1.6	0.7	0.2	-0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.9	0.6	1.4	-0.0	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	-0.9	-0.4	0.1	-0.6
Qualifications: None of the above	0.2	0.4	1.2	0.7	-0.2	-0.0	1.1
Financial difficulties in last 2 years	0.9	1.2	2.1	-0.7	-0.6	1.4	-1.4
Mouth/teeth dental problems	0.9	1.3	2.0	1.3	1.4	1.3	0.0
Heart attack	0.8	1.0	2.0	-0.7	-1.4	-1.2	-0.5
Allergy	0.2	0.4	0.7	-0.8	-0.0	-0.8	0.3
Pain all over the body in last month	0.6	0.6	2.0	0.4	0.2	1.4	0.5
Diabetes (self-reported)	0.3	0.5	0.9	0.6	-1.0	0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.8	1.0	-0.0	1.9	0.7
Medication: Ramipril	1.9	2.4	7.8	1.1	-0.7	-0.3	-2.8
Medication: Simvastatin	0.2	0.3	0.7	-0.1	-0.8	-0.8	0.1
Fluid intelligence score	0.5	1.0	3.5	0.4	0.3	1.9	-0.3
Illnesses of siblings	0.7	0.9	2.9	-0.3	0.7	1.7	0.5
Neuroticism score	0.6	1.3	3.5	-0.9	-0.9	0.0	-1.9
Weight	0.0	0.2	0.3	0.5	-0.4	0.4	0.5
Impedance of arm (right)	0.2	1.0	1.8	-1.4	-1.1	-0.8	-0.4
Arm fat percentage (right)	0.2	0.9	2.9	0.4	-0.6	0.6	1.7
Trunk fat-free mass	0.1	0.5	1.4	0.4	-0.4	-0.2	-1.2
Hip circumference	0.1	0.3	0.8	0.4	-0.1	0.5	0.9
Time employed in main current job	1.4	1.6	4.5	1.3	0.4	-0.2	2.1
Alcohol intake versus 10 years previously	0.4	0.7	1.5	0.7	0.6	1.2	-0.5
Father’s age at death	0.2	0.3	1.1	-0.4	-1.1	-0.2	0.2
Worrier / anxious feelings	0.3	0.5	1.0	0.2	0.9	1.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	5.5	-0.3	-0.3	-1.6	-2.3
Falls in the last year	1.1	1.5	4.7	-0.4	-1.1	0.0	-2.2
Hair/balding pattern: Pattern 3	1.8	2.7	5.6	-1.7	-1.1	-2.4	1.1
Number of live births	1.1	1.6	5.5	2.4	-0.5	0.6	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	0.0	-0.3	-1.2	-0.9
Pulse rate	0.5	0.8	1.4	-0.8	-1.2	0.1	-1.0
Happiness	1.7	2.0	6.7	-0.4	-1.0	-0.4	-2.6
Noisy workplace	0.4	0.5	1.4	1.2	0.4	-0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.4	-1.8	-0.5	-0.4	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.1	-1.5	-0.1	-2.0	1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	2.6	-0.1	-1.6	0.9	-0.9
Asthma	1.3	2.5	4.5	1.3	1.5	2.1	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	0.1	1.1	-1.1	0.3
Medication: Cholesterol lowering	0.1	0.1	0.2	0.2	-0.1	-0.5	-0.4
Depression (self-reported)	1.3	1.5	2.0	-1.4	-1.4	-0.3	-1.4
Medication: Lansoprazole	0.8	1.0	1.9	0.8	-0.8	1.4	-0.8
Prospective memory result	0.2	0.3	0.7	0.9	-0.4	0.3	0.2
Lung cancer (father)	1.0	1.2	2.2	1.1	0.5	1.0	1.5
Illnesses of mother	1.7	2.1	4.6	1.0	2.1	1.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	0.8	0.8	-0.7	-1.1
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	-0.5	-1.2	-1.1	-1.1
Impedance of arm (left)	0.4	1.7	4.3	-2.1	-1.3	-0.4	-0.8
Arm fat mass (right)	0.1	0.6	1.4	0.5	-0.3	0.7	1.2
Trunk predicted mass	0.1	0.5	1.5	0.4	-0.4	-0.1	-1.2
Standing height	0.3	3.0	7.5	-0.9	-1.4	-1.4	-2.7
Length of working week for main job	1.1	1.2	3.6	0.2	1.0	0.1	1.9
Exposure to tobacco smoke at home	1.1	1.2	2.0	1.1	1.0	0.9	1.4
Breastfed as a baby	0.4	0.5	1.5	-0.2	1.2	0.3	0.8
Tense / ‘highly strung’	0.1	0.2	0.5	-0.3	-0.3	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.8	-0.4	0.6	-0.4
Birth weight of first child	0.1	0.1	0.4	0.6	-0.1	0.1	0.3
Peak expiratory flow (PEF)	0.4	1.0	1.9	-0.3	-1.4	-1.4	-0.5
Pulse wave reflection index	0.1	0.1	0.3	0.2	-0.5	0.1	-0.3
Ever highly irritable/argumentative for 2 days	1.5	1.8	5.6	-0.7	-1.0	-0.6	-2.4
Loud music exposure frequency	1.5	1.7	4.6	-0.8	-2.1	-1.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.0	-1.0	-0.6	-0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	-1.4	-0.8	-0.8	0.7
Blood clot in the leg (DVT)	1.1	1.4	5.0	-0.2	-2.2	0.4	-0.7
Medication: Paracetamol	0.5	0.8	2.4	1.6	0.9	-0.1	0.1
Headache pain in last month	0.7	1.2	2.6	-0.1	1.4	1.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	-0.0	1.3	0.2	1.0
Glaucoma (self-reported)	0.6	0.7	1.6	-0.5	0.9	-1.3	0.5
Gout (self-reported)	0.8	1.2	2.8	1.7	1.3	-0.2	-0.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.3	-1.5	-0.6	-1.5	0.7
Medication: Amlodipine	0.5	0.7	1.7	1.3	-0.7	0.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	0.4	-1.2	0.4	-0.4
Birth weight	0.3	0.7	1.9	-0.7	-1.4	0.5	-0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.4	-1.2	-0.7	-1.5	-0.9
High blood pressure (siblings)	0.7	1.0	2.7	0.2	-0.2	-1.6	-1.2
Forced vital capacity (FVC), Best measure	0.4	1.6	2.8	1.7	1.1	-0.4	-1.5
Body fat percentage	0.3	1.0	3.4	0.3	-0.7	0.4	1.8
Leg fat percentage (right)	0.4	1.4	4.8	0.7	-0.2	0.4	2.2
Arm fat-free mass (right)	0.0	0.2	0.7	0.4	-0.4	-0.1	-0.8
Exposure to tobacco smoke outside home	0.7	0.9	2.8	-0.2	-0.3	0.8	-1.7
Comparative body size at age 10	0.7	2.0	5.4	-1.2	-0.1	-2.3	1.1
Number of full brothers	0.8	1.0	3.7	-0.2	0.5	-1.9	-0.2
Worry too long after embarrassment	0.3	0.5	0.8	-0.3	0.8	-0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.4	-0.8	-0.2	-0.5
Wheeze or whistling in the chest in last year	0.6	1.1	2.6	0.3	0.5	1.6	1.3
Number of children fathered	0.2	0.3	0.8	0.9	-0.4	-0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.8	0.5	0.8	0.3	2.2
Age at first live birth	0.4	0.6	2.0	0.7	0.2	-0.2	-1.4
Pulse wave peak to peak time	0.7	0.9	1.3	0.6	1.1	0.9	1.0
Health satisfaction	1.3	1.6	3.1	-0.3	-0.7	-1.8	-1.7
Shortness of breath walking on level ground	1.4	1.7	3.2	-0.9	-1.6	-1.8	-0.6
Qualifications: College or University degree	0.8	2.6	6.6	0.9	2.6	1.7	-0.1
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.2	-0.5	0.1	0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.5	-0.3	0.1	-1.6	1.4
Emphysema/chronic bronchitis	0.8	0.9	3.2	-0.4	-0.4	0.1	-1.8
Medication for pain relief, constipation, heartburn	0.5	0.8	2.1	-1.0	0.4	1.4	0.3
Neck or shoulder pain in last month	0.5	0.7	1.4	0.8	0.4	-0.8	1.2
Medication: Blood pressure	0.9	1.5	4.6	-0.2	-2.1	-0.6	-1.1
Angina (self-reported)	0.7	0.9	1.8	0.3	-0.1	-1.4	-1.2
Migraine (self-reported)	0.3	0.4	0.8	-0.9	0.4	-0.6	0.6
Medication: Ibuprofen	0.5	0.6	1.5	0.5	0.7	-1.2	0.3
Medication: Allopurinol	0.5	0.7	2.3	0.4	1.5	-0.1	0.5
Medication: Omeprazole	0.1	0.1	0.2	0.2	0.5	0.0	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.2	-0.6	0.5	-0.4	1.1
Mean time to correctly identify matches	0.7	1.2	3.4	-0.4	-0.8	0.8	-1.8
Heart disease (mother)	1.0	1.2	3.4	0.1	-0.6	-1.9	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	-0.3	-0.6	-0.3	1.1
Whole body fat mass	0.1	0.5	1.5	0.4	-0.3	0.3	1.2
Leg fat mass (right)	0.1	0.6	1.8	0.7	-0.1	0.2	1.3
Arm predicted mass (right)	0.1	0.3	0.7	0.2	-0.6	-0.2	-0.8
Pulse rate, automated reading	0.2	0.7	2.2	-0.2	-1.5	0.7	0.2
Alcohol intake frequency.	0.3	0.8	2.2	0.8	1.5	0.2	0.4
Comparative height size at age 10	0.4	2.0	3.1	0.7	-1.8	-1.3	-1.6
Number of full sisters	1.0	1.2	3.3	-0.2	-1.8	-0.8	-0.9
Suffer from ‘nerves’	0.1	0.2	0.4	0.3	-0.5	-0.6	-0.3
Overall health rating	1.0	2.1	5.8	0.0	-1.2	-1.2	-2.4
Chest pain or discomfort	0.5	0.8	1.2	1.1	1.0	0.7	-0.6
Had major operations	0.7	0.9	1.9	1.4	1.0	0.5	0.5
Age at last live birth	0.9	1.3	3.1	0.9	0.7	0.9	-1.8
Family relationship satisfaction	1.0	1.2	2.5	-0.3	-1.5	0.1	-1.6
Leg pain on walking	0.4	0.5	1.1	1.0	0.1	-0.0	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.9	0.0	1.2	-0.3	-1.4
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.2	-1.2	-2.3	-0.8	-1.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	0.5	0.9	0.3	0.3
Medication: Aspirin	1.0	1.4	3.5	0.2	-1.9	-1.4	-0.0
Supplements: Vitamin C	0.3	0.3	0.9	0.2	0.2	-0.9	0.5
Knee pain experienced in last month	0.2	0.3	1.3	-0.2	-0.1	0.0	-1.1
Hypertension (Self-reported)	0.3	0.9	3.2	-0.1	-1.8	-0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.7	-0.7	-2.2	-0.8	-1.1
Illnesses of father: Heart disease	0.7	0.9	2.6	-1.6	-0.8	-0.7	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.8	-0.9	0.5	0.6
Smoking status: Previous	1.1	1.6	2.9	-0.6	-1.6	0.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.7	-0.5	1.1	2.2	0.1
Whole body fat-free mass	0.1	0.4	1.1	0.5	-0.5	-0.1	-1.0
Leg fat-free mass (right)	0.0	0.2	0.6	0.4	-0.4	0.3	-0.7
Arm fat percentage (left)	0.2	0.9	2.6	0.3	-0.6	0.8	1.6
Average weekly red wine intake	0.3	0.5	1.2	0.7	0.5	-1.1	0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.7	0.9	-0.3	0.6
Mood swings	0.8	1.5	4.1	-0.9	-2.0	0.4	-1.1
Loneliness, isolation	0.2	0.2	0.5	0.7	0.2	0.5	-0.3
Long-standing illness, disability or infirmity	2.1	3.3	4.7	-1.0	-2.1	-2.2	-1.7
Ever had bowel cancer screening	0.1	0.1	0.4	0.0	0.3	-0.1	0.6
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.8	-0.4	0.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.1	1.4	1.3	0.1	0.5
Friendships satisfaction	0.0	0.0	0.1	0.2	-0.1	0.3	-0.1
Qualifications: nursing, teaching	0.7	1.1	1.5	1.2	1.0	1.2	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	-0.4	0.2	0.3
Eye problems/disorders: Cataract	0.5	0.5	1.4	0.6	0.4	0.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.9	-0.4	0.1	-2.0	0.6
Medication for cholesterol	0.1	0.2	0.6	-0.7	-0.0	-0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.6	0.8	0.1	0.1
Back pain experienced in last month	0.1	0.2	0.3	-0.1	0.3	-0.6	-0.5
Mineral and other dietary supplements	0.8	1.1	1.9	-1.3	0.0	0.8	1.4
Breast cancer (self-reported)	1.5	1.8	5.7	2.4	1.2	0.3	-0.2
Asthma (self-reported)	1.1	2.3	3.7	1.1	1.5	1.9	1.3
Osteoporosis (self-reported)	0.1	0.1	0.4	0.3	-0.2	-0.6	-0.1
Osteoarthritis (self-reported)	0.6	0.8	1.8	1.1	-0.0	-1.3	-0.1
Medication: Aspirin	1.1	1.4	2.8	0.3	-1.6	-1.7	0.3
Medication: Gliclazide	0.3	0.3	0.7	0.6	0.2	-0.8	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	0.0	0.3	0.8	-1.3
Smoking status: Current	0.3	0.5	0.9	0.9	0.6	0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.3	-0.4	-0.1	-0.7
Whole body water mass	0.1	0.3	1.1	0.4	-0.4	-0.0	-1.0
Leg predicted mass (right)	0.0	0.2	0.5	0.4	-0.3	0.4	-0.7
Arm fat mass (left)	0.1	0.5	1.1	0.4	-0.5	0.6	1.1
Number of self-reported non-cancer illnesses	1.7	3.0	6.3	-1.3	-2.5	-1.5	-1.3
Average weekly champagne plus white wine intake	0.5	0.7	2.2	-0.4	-0.8	1.5	-0.0
Miserableness	0.6	1.0	3.7	0.6	0.1	0.1	-1.9
Guilty feelings	0.8	1.1	1.6	-0.2	-1.2	-1.3	-1.2
Wears glasses or contact lenses	0.2	0.2	0.5	-0.7	0.2	0.5	0.4
Ever taken oral contraceptive pill	1.4	1.6	4.1	-0.7	0.7	2.0	1.0
Hearing aid user	0.2	0.2	0.8	0.0	0.0	-0.9	-0.4
Mother’s age at death	1.2	1.5	3.8	-2.0	-1.5	0.1	0.2
Financial situation satisfaction	0.9	1.1	2.1	0.8	0.5	1.4	-1.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.9	1.7	1.5	0.3	0.2
Commuting to job workplace: Public transport	1.2	1.4	4.3	1.1	2.1	0.4	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	-0.5	-0.1	-1.1	0.9
Medication: Blood pressure	0.2	0.4	0.6	0.6	-0.5	-0.8	0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.7	1.1	-0.3	-1.3	-1.2
Supplements: Fish oil (including cod liver oil)	1.9	2.5	3.2	1.7	-1.2	-1.6	-1.8
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.0	-0.0	0.3	1.1
Medication: Bendroflumethiazide	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.0
Medication: Paracetamol	0.2	0.4	1.3	1.2	-0.2	-0.0	-0.0
Medication: Lisinopril	1.5	1.9	2.8	-1.4	-1.1	-1.7	1.2
Medication: Atorvastatin	0.4	0.5	1.5	1.2	0.3	0.0	-0.5
Illnesses of father: High blood pressure	0.5	0.6	2.4	1.5	-0.1	0.0	-0.2
Alcohol drinker status: Never	0.6	0.8	1.6	0.8	0.9	1.3	0.2
Ever smoked	0.2	0.3	0.9	0.9	0.2	0.4	-0.3
Basal metabolic rate	0.0	0.2	0.5	0.4	-0.5	0.0	-0.7
Leg fat percentage (left)	0.5	1.7	5.4	1.0	0.0	0.8	2.3
Arm fat-free mass (left)	0.0	0.2	0.6	0.8	-0.2	-0.1	-0.4
Number of operations (self-reported)	0.1	0.2	0.2	0.5	0.1	-0.5	-0.5
Average weekly beer plus cider intake	1.2	1.7	3.8	-0.9	-1.5	-0.3	-2.0
Irritability	1.9	3.3	5.7	-2.4	-1.7	0.5	-2.1
Risk taking	0.7	1.1	1.4	1.1	1.1	0.7	1.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.3	-0.0	0.3	1.1	-0.4
Fractured/broken bones in last 5 years	2.2	2.8	6.6	-1.5	-2.6	-0.5	-1.4
Age started oral contraceptive pill	0.6	0.7	1.5	0.3	1.1	1.2	0.3
Diastolic blood pressure, automated reading	0.4	1.4	3.6	-0.7	-1.9	-0.0	1.2
Ever depressed for a whole week	0.4	0.4	1.0	-0.8	-1.0	-0.2	0.1
Unable to work because of sickness or disability	2.0	2.6	8.5	0.0	-1.1	0.7	-2.9
Commuting to job workplace: Cycle	1.8	2.2	5.4	0.1	2.3	0.8	1.7
Myopia	1.3	1.8	4.7	0.3	2.2	0.8	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.4	0.2	2.1	0.6	0.9
Cholesterol lowering medication	0.2	0.3	0.9	0.3	0.4	-0.4	1.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.0	0.4	0.1	0.6
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.4
Supplements: Calcium	0.4	0.4	1.2	-0.0	-1.1	-0.2	-0.6
Basal cell carcinoma (self-reported)	0.8	0.9	2.9	1.7	0.2	0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.9	-0.6	-1.4	-1.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	5.7	-0.5	-2.4	-0.0	-0.7
Heart disease (siblings)	2.1	2.6	5.5	-0.2	-1.5	-2.3	-1.6
Alcohol drinker status: Previous	1.2	1.3	2.5	-1.6	-1.2	-1.0	-0.6
Pack years of smoking	0.6	0.8	2.2	1.5	-0.9	0.5	-0.2
Impedance of whole body	0.3	1.8	4.7	-2.2	-1.4	-0.6	-0.4
Leg fat mass (left)	0.2	0.7	2.2	0.6	-0.1	0.4	1.5
Arm predicted mass (left)	0.0	0.2	0.5	0.7	-0.4	0.0	-0.5