Hub : Genes

SDCBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1940	0.0610	2.0e-04	0.172	NA	0.108	NA	0.151	3.7e-08	NA	1.4e-05	NA	2.7e-07
2	GTEx	Spleen	0.4730	0.0990	4.1e-06	0.225	NA	0.322	NA	0.265	1.8e-06	NA	4.9e-09	NA	1.7e-07
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0409	0.0232	9.9e-04	0.023	0.03	0.031	NA	0.031	1.1e-03	0.00024	1.8e-04	NA	2.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.3	0.8	0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.3	0.2	0.4
Depressed Affect (Nagel 2018)	0.4	0.9	1.6	-0.3	-0.9	-1.2
Depression (Nagel 2018)	0.3	0.5	0.9	0.2	-0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	0.6	-0.7	0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.5	-0.1	-0.4	-1.2
Schizophrenia (2018)	0.0	0.1	0.2	-0.2	-0.4	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	1.7	0.7	-1.3	-0.6
Worry (Nagel 2018)	0.2	0.4	0.7	-0.8	0.7	0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.5	-0.3	-0.4
Alzheimer’s Disease (in father)	0.2	0.3	0.8	0.9	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.6	0.5	-0.1
Crohns Disease (2017)	0.2	0.5	1.4	-1.2	-0.1	0.2
Irritable Bowel Disease (IBD)	0.3	0.8	2.0	-1.4	0.3	0.6
Ulcerative Colitis (UC)	0.9	1.7	2.0	-1.4	1.1	1.4
Major Depression (MDD)	3.6	4.4	9.1	1.7	-3.0	-1.1
Reaction Time	0.1	0.2	0.4	-0.1	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.0	1.0	-0.7	-0.7
Breast Cancer	2.5	6.1	8.5	2.9	-2.6	-1.7
Ovarian Cancer	0.9	1.2	1.8	0.9	-1.3	-1.0
Prostate Cancer	1.3	1.8	3.1	1.2	-1.0	-1.8
Age at First Birth	0.0	0.0	0.0	0.1	0.0	-0.0
Bipolar Disorder (2011)	0.4	0.4	0.9	0.5	-0.9	-0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.6	0.0	0.5
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.4	-0.4	-0.7
Crohns Disease (2012)	0.7	1.1	2.4	-1.6	0.4	0.9
Mean Putamen Volume	6.9	7.9	8.9	2.7	-3.0	-2.8
Fasting Glucose	1.1	1.3	2.0	1.2	-1.4	-0.8
HbA1C	0.4	0.5	1.0	1.0	-0.7	-0.1
HDL Cholesterol	0.0	0.0	0.1	-0.1	-0.2	0.2
LDL Cholesterol	12.5	19.8	26.1	-5.1	3.9	4.3
Lupus	0.6	0.9	2.5	-1.6	0.4	0.2
Neuroticism (2016)	0.4	0.6	1.5	-1.2	-0.5	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.0	-0.5	-0.2
Rheumatoid Arthritis	0.0	0.0	0.1	0.0	-0.4	-0.0
Schizophrenia (2014)	0.0	0.1	0.2	0.1	-0.2	0.4
Triglycerides	5.5	9.0	15.2	-3.9	2.9	1.9
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.1	1.8	-1.6	-1.3
Ulcerative Colitis	0.3	0.4	0.5	-0.6	-0.5	0.7
Blood Eosinophil Count	1.0	8.0	9.3	-2.8	2.6	3.1
Blood Platelet Count	0.3	3.1	4.7	-2.2	1.8	1.3
Blood Red Count	1.2	11.7	14.7	-3.8	3.8	2.4
Blood White Count	1.2	8.8	10.0	-3.1	3.2	2.6
Heel T-Score	0.3	2.6	4.8	-1.6	2.2	0.7
BMI	2.0	11.6	14.1	-3.3	3.2	3.8
Height	0.7	12.7	14.1	3.2	-3.7	-3.8
Waist Hip Ratio (WHR)	0.5	2.2	3.8	-1.4	0.8	2.0
Systolic Blood Pressure	0.1	0.7	2.1	0.2	-1.5	0.2
Smoking Status	3.3	8.0	12.0	2.2	-3.5	-2.7
Allergy or Eczema	3.0	7.9	10.1	-3.2	2.6	2.6
Cardiovascular Disease	4.4	14.4	19.5	-4.4	4.2	2.5
Hypothyroidism (self reported)	0.1	0.3	0.8	-0.9	0.4	-0.1
Respiratory disease	1.1	2.5	4.6	-1.4	0.9	2.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.5	-0.4	0.2	1.6
Lung FEV1/FVC ratio	0.6	3.2	4.7	-2.2	2.1	0.7
Lung FVC	0.4	2.2	4.4	-2.1	0.9	1.1
Neuroticism	0.2	0.6	1.0	-0.8	0.1	-1.0
Chronotype (morning person)	0.0	0.0	0.0	-0.1	-0.2	0.1
Hair Pigment	0.6	17.3	21.2	4.6	-3.8	-4.0
Tanning	0.0	0.6	1.5	-1.2	0.2	0.4
Hand grip strength (left)	0.1	0.3	0.4	-0.6	0.7	-0.0
Number of treatments/medications taken	1.7	3.0	5.1	-2.3	1.4	1.4
Average weekly spirits intake	0.3	0.4	0.6	-0.8	0.6	0.4
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.0	0.2	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.4	-0.6	0.0
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.0	-0.4	-0.8
Relative age of first facial hair	0.3	0.6	1.5	-0.7	1.2	0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.0	0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.2	-0.3	-0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.1	0.1	0.5
Systolic blood pressure, automated reading	0.6	1.9	3.0	-1.6	0.3	1.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	-0.5	-0.3
Angina	0.2	0.2	0.6	-0.3	0.1	-0.8
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.7	0.9	-0.0
Vitamin and mineral supplements	0.2	0.2	0.5	-0.7	0.3	0.3
Supplements: Zinc	0.8	0.9	1.6	0.8	-0.6	-1.3
Medication: Co-codamol	1.5	1.7	2.2	1.5	-1.5	-0.8
Medication: Metformin	1.6	2.2	3.4	-1.5	1.0	1.8
Diabetes (father)	3.0	3.7	4.5	1.9	-2.1	-1.7
Diabetes (mother)	1.2	1.5	2.0	1.4	-1.3	-0.9
Severe depression (siblings)	0.3	0.3	0.9	-1.0	-0.1	0.3
Pack years adult smoking proportion	0.4	0.6	1.7	-0.1	1.3	-0.3
Impedance of leg (right)	2.7	13.0	15.3	3.9	-3.5	-3.4
Leg fat-free mass (left)	0.2	1.2	1.7	-1.3	0.8	1.2
Trunk fat percentage	0.1	0.2	0.6	0.0	0.3	0.7
Hand grip strength (right)	0.0	0.1	0.2	-0.5	0.4	0.1
Townsend deprivation index at recruitment	2.7	3.8	4.1	2.0	-2.0	-1.8
Current tobacco smoking	2.2	3.6	3.9	1.9	-2.0	-1.8
Average weekly fortified wine intake	3.9	4.6	5.7	-1.9	2.1	2.4
Maternal smoking around birth	1.6	2.4	3.6	1.8	-1.9	-0.4
Fed-up feelings	0.5	0.9	1.7	0.4	-1.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.6	0.6	-1.1	-1.6
Relative age voice broke	2.6	4.0	5.7	-2.4	2.2	1.1
Taking other prescription medications	1.1	1.7	3.3	-1.2	0.6	1.8
Age when periods started (menarche)	0.3	0.7	1.0	0.7	-1.0	-0.8
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	6.7	-1.6	1.9	2.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-1.0	-0.0	0.3
Tinnitus: Yes, but not now, but have in the past	5.0	5.3	6.4	2.5	-2.0	-2.3
Qualifications: CSEs or equivalent	1.8	2.4	4.0	2.0	-0.9	-1.5
Serious illness, injury or assault to yourself	0.9	1.1	1.9	-1.4	0.9	-0.7
High blood pressure	1.3	3.5	6.3	-2.5	1.4	1.5
Hayfever, allergic rhinitis or eczema	1.7	3.6	5.0	-2.2	1.5	1.9
Multivitamins +/- minerals	0.9	1.2	1.6	-1.1	1.2	0.9
Stomach or abdominal pain in last month	0.8	1.0	1.4	1.0	-1.2	-0.7
Supplements: Glucosamine	0.8	1.0	1.6	1.3	-0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.6	-0.4	0.3
Medication: Atenolol	1.8	2.3	2.9	-1.7	1.3	1.5
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.2	-0.3	-0.0
Sitting height	0.7	5.0	7.3	2.2	-2.7	-1.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.2	0.5
High blood pressure (mother)	0.6	0.8	1.3	0.9	-1.2	-0.5
Body mass index (BMI)	2.7	11.4	14.3	-3.8	3.1	3.2
Impedance of leg (left)	2.3	11.3	13.4	3.7	-3.2	-3.2
Leg predicted mass (left)	0.2	1.3	1.8	-1.4	0.8	1.2
Trunk fat mass	0.2	0.7	1.1	-0.7	0.7	1.0
Waist circumference	1.4	5.0	6.3	-2.5	2.1	2.1
Number of incorrect matches in round	0.3	0.5	0.8	0.8	0.4	-0.9
Past tobacco smoking	1.1	2.0	3.9	-0.8	2.0	1.2
Alcohol usually taken with meals	0.4	0.7	1.2	-0.5	1.1	0.8
Nervous feelings	0.5	1.0	1.1	-1.0	1.0	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.0	1.0	-1.0	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.3	0.5	-0.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.2	0.4	-1.1	-0.8
Had menopause	0.6	0.8	1.4	-0.8	1.2	0.5
Had other major operations	8.3	10.1	14.6	-3.2	3.8	2.4
Forced vital capacity (FVC)	0.4	1.6	2.7	1.0	-1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.0	-1.7	0.8	1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.5	-0.7	-0.8	-1.2
Qualifications: None of the above	0.6	1.3	2.7	0.7	-0.8	-1.7
Financial difficulties in last 2 years	1.1	1.4	3.3	0.5	-1.8	-0.9
Mouth/teeth dental problems	0.7	1.1	2.7	0.7	-0.3	1.7
Heart attack	0.0	0.0	0.1	-0.1	-0.3	0.2
Allergy	2.0	4.5	5.6	2.4	-1.8	-2.1
Pain all over the body in last month	0.2	0.2	0.2	-0.3	-0.5	-0.5
Diabetes (self-reported)	2.0	3.1	4.5	-1.5	1.6	2.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.1	-0.5	0.4
Medication: Ramipril	0.2	0.2	0.6	-0.2	-0.1	0.8
Medication: Simvastatin	1.5	2.2	3.4	-1.9	1.8	-0.1
Fluid intelligence score	0.0	0.0	0.1	0.3	-0.1	0.0
Illnesses of siblings	0.7	1.0	1.9	1.4	-0.6	-0.8
Neuroticism score	0.3	0.6	1.3	0.2	-0.6	-1.1
Weight	0.6	2.8	4.3	-2.1	1.2	1.6
Impedance of arm (right)	4.3	20.1	29.8	5.5	-4.2	-3.6
Arm fat percentage (right)	0.9	3.5	3.7	-1.9	1.9	1.9
Trunk fat-free mass	0.8	4.7	9.3	-3.0	1.6	1.4
Hip circumference	0.1	0.4	0.8	-0.9	0.5	0.6
Time employed in main current job	3.2	3.7	5.6	-2.4	1.3	2.0
Alcohol intake versus 10 years previously	0.3	0.5	1.1	0.3	-0.6	-1.1
Father’s age at death	0.9	1.2	2.1	-0.8	1.5	0.9
Worrier / anxious feelings	0.0	0.1	0.3	-0.1	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	2.6	0.9	-1.6	-1.5
Falls in the last year	0.5	0.7	1.2	-0.9	1.1	-0.2
Hair/balding pattern: Pattern 3	1.1	1.7	1.9	-1.4	1.2	1.4
Number of live births	1.1	1.5	2.5	0.8	-1.2	-1.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.9	0.3	-1.0	-0.6
Pulse rate	2.3	3.9	5.2	-2.1	2.3	1.4
Happiness	1.2	1.4	1.9	0.8	-1.3	-1.4
Noisy workplace	1.6	1.9	3.9	1.1	-2.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.8	-0.7	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.5	1.1	-1.2	-1.2
Mouth/teeth dental problems: Dentures	1.0	1.6	3.3	-1.8	1.3	0.1
Asthma	0.4	0.8	1.5	-0.8	0.5	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.5	0.3	0.1
Medication: Cholesterol lowering	4.4	6.8	13.4	-3.7	2.3	1.4
Depression (self-reported)	2.0	2.4	3.5	1.4	-1.9	-1.3
Medication: Lansoprazole	1.5	1.7	3.6	-1.9	1.0	0.8
Prospective memory result	0.3	0.4	0.8	0.1	-0.9	-0.5
Lung cancer (father)	1.1	1.3	2.1	-0.9	1.0	1.4
Illnesses of mother	0.3	0.4	1.0	-1.0	0.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	-0.5	-0.5	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.2	0.7	-0.0
Impedance of arm (left)	5.2	24.1	37.1	6.1	-4.4	-4.0
Arm fat mass (right)	1.3	5.4	5.9	-2.4	2.2	2.3
Trunk predicted mass	0.7	4.2	8.7	-2.9	1.5	1.3
Standing height	1.1	10.7	13.5	3.1	-3.7	-3.0
Length of working week for main job	2.6	2.9	4.0	1.4	-1.6	-2.0
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.0	0.3	0.2
Breastfed as a baby	0.3	0.4	0.8	-0.4	0.9	0.4
Tense / ‘highly strung’	0.6	1.0	2.1	0.4	-1.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.1	-1.0	0.7	0.6
Hair/balding pattern: Pattern 4	0.4	1.0	1.6	0.8	-0.9	-1.3
Birth weight of first child	0.0	0.0	0.1	-0.3	0.2	-0.1
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.7	0.2	0.6
Pulse wave reflection index	0.2	0.2	0.4	-0.6	0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.5	-0.9	0.3
Loud music exposure frequency	1.4	1.5	4.3	0.4	-2.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.3	0.5	-1.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-1.4	0.6	0.3
Blood clot in the leg (DVT)	0.5	0.7	1.1	-1.1	0.5	-0.8
Medication: Paracetamol	0.3	0.5	1.5	0.1	-0.4	-1.2
Headache pain in last month	1.0	1.7	4.0	0.7	-0.8	-2.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	5.7	2.4	-1.7	-1.3
Glaucoma (self-reported)	1.7	2.0	3.7	-1.4	1.9	0.6
Gout (self-reported)	1.0	1.4	1.9	0.7	-1.4	-1.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	0.4	0.2
Medication: Amlodipine	0.9	1.3	2.8	-0.8	1.7	0.7
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.9	-2.0	1.5	0.8
Birth weight	0.2	0.4	0.8	0.4	0.6	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	0.6	1.3	0.4
High blood pressure (siblings)	2.4	3.5	4.8	-2.2	1.8	1.5
Forced vital capacity (FVC), Best measure	0.3	1.0	2.3	0.4	-1.5	-0.7
Body fat percentage	0.2	0.8	1.1	-0.7	0.8	1.1
Leg fat percentage (right)	1.1	3.8	4.6	-2.1	1.7	2.0
Arm fat-free mass (right)	0.4	2.2	4.6	-2.1	1.1	0.9
Exposure to tobacco smoke outside home	3.0	4.0	5.5	-1.9	1.7	2.3
Comparative body size at age 10	0.2	0.6	1.0	1.0	-0.6	-0.7
Number of full brothers	2.1	2.6	3.6	1.9	-1.2	-1.7
Worry too long after embarrassment	0.2	0.4	0.6	-0.5	0.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.2	-0.5	0.6
Wheeze or whistling in the chest in last year	0.6	1.1	1.5	1.0	-1.2	-1.0
Number of children fathered	1.2	1.3	2.3	-1.5	-0.0	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.6	-0.7	0.3
Age at first live birth	0.1	0.1	0.2	0.4	-0.3	0.1
Pulse wave peak to peak time	0.3	0.4	0.9	0.4	-1.0	-0.3
Health satisfaction	0.3	0.4	0.6	-0.3	-0.7	-0.8
Shortness of breath walking on level ground	1.5	1.8	2.8	-1.7	1.2	1.1
Qualifications: College or University degree	0.6	2.0	4.1	-0.9	2.0	1.0
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.1	-0.9	0.3
Mouth/teeth dental problems: Loose teeth	3.4	4.1	5.8	1.6	-2.0	-2.4
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.7	0.2	-0.1
Medication for pain relief, constipation, heartburn	2.5	4.2	8.1	2.8	-1.8	-1.1
Neck or shoulder pain in last month	1.0	1.4	2.7	1.0	-0.7	-1.6
Medication: Blood pressure	0.2	0.4	0.4	-0.7	0.6	0.6
Angina (self-reported)	0.1	0.1	0.2	-0.4	0.3	-0.5
Migraine (self-reported)	0.7	0.9	1.8	0.6	-0.7	-1.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.3	0.4	-0.2
Medication: Allopurinol	0.1	0.1	0.2	-0.5	-0.0	0.2
Medication: Omeprazole	2.5	2.9	3.2	-1.8	1.7	1.6
Medication: Seretide 50 evohaler	0.9	1.1	1.4	-0.9	1.0	1.2
Mean time to correctly identify matches	0.5	1.0	2.2	-0.8	1.5	0.5
Heart disease (mother)	0.1	0.1	0.3	-0.1	0.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	0.4	-0.6	-0.6
Whole body fat mass	0.3	1.4	1.6	-1.2	1.1	1.2
Leg fat mass (right)	0.6	2.3	2.9	-1.7	1.3	1.6
Arm predicted mass (right)	0.6	3.0	5.6	-2.4	1.4	1.2
Pulse rate, automated reading	3.2	10.2	13.1	-3.6	3.4	2.5
Alcohol intake frequency.	0.2	0.4	0.7	0.1	0.7	-0.8
Comparative height size at age 10	0.1	0.5	0.7	0.7	-0.6	-0.8
Number of full sisters	0.1	0.2	0.3	0.4	-0.5	-0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.5	0.1	0.3
Overall health rating	0.5	1.0	2.4	-1.6	0.8	0.0
Chest pain or discomfort	1.0	1.5	2.5	-1.2	1.6	0.6
Had major operations	0.0	0.0	0.0	-0.2	-0.0	-0.0
Age at last live birth	0.1	0.1	0.3	0.3	-0.6	-0.1
Family relationship satisfaction	0.2	0.3	0.5	-0.4	-0.4	0.7
Leg pain on walking	0.2	0.3	0.5	-0.7	0.6	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	0.1	0.3
Commuting to job workplace: Car/motor vehicle	3.5	4.0	4.8	1.7	-2.0	-2.2
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.2	-0.7	1.1	2.1
Medication: Aspirin	3.0	3.9	4.5	-2.1	2.0	1.8
Supplements: Vitamin C	0.7	0.8	0.8	0.9	-0.8	-0.9
Knee pain experienced in last month	0.2	0.3	0.4	-0.6	0.3	0.6
Hypertension (Self-reported)	1.3	3.6	6.4	-2.5	1.5	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.0	5.9	9.0	-3.0	2.7	1.2
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.1	-0.6	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.8	-0.9	0.1
Smoking status: Previous	0.8	1.2	2.1	0.4	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.8	9.8	2.2	-3.1	-2.5
Whole body fat-free mass	0.6	3.3	5.9	-2.4	1.4	1.4
Leg fat-free mass (right)	0.3	1.4	2.0	-1.4	0.8	1.2
Arm fat percentage (left)	0.7	2.9	3.1	-1.6	1.8	1.8
Average weekly red wine intake	0.2	0.2	0.7	-0.3	0.8	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	0.1	1.2	0.6
Mood swings	0.6	1.1	2.2	0.6	-1.5	-0.9
Loneliness, isolation	0.4	0.6	1.5	-0.1	-0.4	-1.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.0	0.3	-0.5
Ever had bowel cancer screening	1.0	1.2	1.8	1.3	-1.1	-0.7
Diabetes diagnosed by doctor	0.8	1.2	2.0	-0.9	1.0	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.8	-0.9	1.4	0.6
Friendships satisfaction	0.2	0.2	0.5	-0.1	-0.7	0.2
Qualifications: nursing, teaching	0.2	0.3	0.4	0.2	-0.6	0.6
Commuting to job workplace: Walk	0.5	0.6	1.1	-0.2	0.7	1.0
Eye problems/disorders: Cataract	0.6	0.7	1.9	1.4	-0.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	0.0	0.6	-1.5
Medication for cholesterol	2.0	3.1	4.6	2.1	-2.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.5	0.6	-0.0
Back pain experienced in last month	0.4	0.5	1.2	-1.1	0.3	-0.5
Mineral and other dietary supplements	1.4	1.8	3.3	-1.8	1.2	0.9
Breast cancer (self-reported)	0.8	1.0	1.5	-1.2	0.7	0.9
Asthma (self-reported)	0.4	0.7	1.3	-0.8	0.6	1.1
Osteoporosis (self-reported)	0.5	0.7	1.0	1.0	-0.9	-0.3
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.4	-0.8	-0.8
Medication: Aspirin	3.2	4.2	5.1	-2.3	2.1	1.7
Medication: Gliclazide	0.8	0.9	2.2	-0.5	0.4	1.5
Illnesses of father: None of the above (group 1)	1.2	1.4	3.0	-0.9	1.7	0.7
Smoking status: Current	1.3	2.0	2.5	1.4	-1.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	-1.5	0.8	0.1
Whole body water mass	0.6	3.2	5.9	-2.4	1.4	1.4
Leg predicted mass (right)	0.3	1.5	2.2	-1.5	0.9	1.3
Arm fat mass (left)	1.2	5.1	5.7	-2.4	2.1	2.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-1.0	0.0	0.2
Average weekly champagne plus white wine intake	2.5	3.4	6.6	-1.9	2.6	0.5
Miserableness	0.1	0.1	0.2	-0.3	-0.5	-0.3
Guilty feelings	0.0	0.0	0.1	-0.1	0.3	-0.1
Wears glasses or contact lenses	1.6	1.9	3.0	-1.7	1.5	0.5
Ever taken oral contraceptive pill	1.5	1.7	3.8	0.1	-1.2	-1.9
Hearing aid user	0.2	0.3	0.8	-0.1	0.2	-0.9
Mother’s age at death	2.7	3.4	6.4	-1.3	2.5	1.4
Financial situation satisfaction	2.9	3.6	7.2	1.3	-2.7	-1.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	0.4	-0.9	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.5	0.0	-0.0
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	-0.9	1.9	1.2
Medication: Blood pressure	0.7	1.2	1.6	-1.2	1.2	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.7	1.0	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	-0.4	0.8	0.9
High cholesterol (Self-reported)	8.8	15.6	23.0	-4.8	4.6	1.7
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.2	0.2	-0.2
Medication: Paracetamol	0.2	0.3	0.9	-0.1	-0.1	-1.0
Medication: Lisinopril	0.1	0.2	0.5	-0.1	-0.7	0.2
Medication: Atorvastatin	6.1	7.6	12.3	-3.5	2.7	1.7
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	-0.3	-0.2
Alcohol drinker status: Never	1.0	1.2	1.7	1.1	-0.8	-1.3
Ever smoked	1.0	1.8	3.4	1.1	-1.9	-0.8
Basal metabolic rate	0.6	3.1	5.4	-2.3	1.3	1.4
Leg fat percentage (left)	1.3	4.6	5.4	-2.3	2.0	2.2
Arm fat-free mass (left)	1.1	5.8	10.3	-3.2	1.8	2.0
Number of operations (self-reported)	1.1	1.6	2.0	-1.3	1.4	1.1
Average weekly beer plus cider intake	5.5	7.9	9.2	3.0	-3.0	-2.4
Irritability	0.1	0.2	0.3	0.2	-0.6	-0.6
Risk taking	1.3	1.8	2.2	-1.4	1.5	1.1
Ever had prostate specific antigen (PSA) test	4.9	5.6	8.8	-1.8	3.0	2.2
Fractured/broken bones in last 5 years	5.0	6.4	8.2	2.9	-2.2	-2.5
Age started oral contraceptive pill	0.6	0.7	1.8	-0.4	1.3	0.5
Diastolic blood pressure, automated reading	0.4	1.1	2.5	-1.6	0.1	0.9
Ever depressed for a whole week	1.6	2.0	3.5	0.6	-1.9	-1.4
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.7	-0.1	0.2
Commuting to job workplace: Cycle	1.0	1.2	1.6	0.9	-1.3	-1.1
Myopia	0.0	0.0	0.0	0.0	0.1	-0.0
Vascular/heart problems diagnosed by doctor	1.0	2.7	5.6	2.4	-1.1	-1.1
Cholesterol lowering medication	5.3	7.7	12.3	-3.0	3.5	1.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	-0.7	0.6	0.7
Pain experienced in last month	2.2	3.7	7.1	-1.1	1.6	2.7
Supplements: Calcium	0.7	0.8	1.8	1.4	-0.6	-0.5
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	0.3	-0.5	-1.4
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.7	0.1	-1.1
Heart disease (siblings)	0.8	0.9	2.2	-0.6	0.5	1.5
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.2	0.5	0.4
Pack years of smoking	0.8	1.1	3.2	-0.4	1.8	-0.1
Impedance of whole body	4.8	24.4	34.5	5.9	-4.6	-4.2
Leg fat mass (left)	0.7	2.7	3.4	-1.8	1.4	1.7
Arm predicted mass (left)	1.1	5.7	10.4	-3.2	1.8	1.8