Hub : Genes

SEC11A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.2680 0.0990 7.5e-03 0.091 NA 0.000 NA 0.108 7.0e-04 NA 3.2e-01 NA 2.2e-04
2 METSIM Adipose 0.0494 0.0213 8.8e-04 0.008 0.018 0.026 0.020 0.008 2.0e-02 8.1e-04 7.9e-05 0.00041 1.8e-02
3 YFS Blood 0.0192 0.0075 4.4e-05 0.014 0.013 0.018 0.014 0.017 1.5e-05 3.2e-05 9.3e-07 0.00002 1.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 1.2 1.1 0.6 0.2
Bipolar Disorder or Schizophrenia 1.1 2.7 4.3 2.1 1.6 1.1
Depressed Affect (Nagel 2018) 0.6 1.3 2.2 -0.4 -1.5 -1.2
Depression (Nagel 2018) 0.1 0.1 0.2 0.3 -0.4 0.2
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 0.8 -1.2 -0.1
Neuroticism (Nagel 2018) 0.7 1.6 2.9 1.1 -1.7 -0.8
Schizophrenia (2018) 1.1 2.4 3.2 1.8 1.6 1.2
Schizophrenia vs Biploar Disorder 0.6 0.8 1.4 1.2 -0.4 0.9
Worry (Nagel 2018) 1.0 2.1 4.8 2.2 -1.2 -0.0
Alzheimer’s Disease (in mother) 0.7 0.8 1.2 1.1 0.3 1.1
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.2 0.1 -0.5
Alzheimer’s Disease (including proxy) 0.9 1.2 2.7 1.7 0.3 0.9
Crohns Disease (2017) 0.2 0.5 1.0 -0.7 0.2 -1.0
Irritable Bowel Disease (IBD) 0.7 1.7 3.6 -1.9 0.0 -1.2
Ulcerative Colitis (UC) 0.9 1.7 3.0 -1.7 -0.8 -1.2
Major Depression (MDD) 0.1 0.1 0.2 0.5 -0.3 0.2
Reaction Time 1.0 1.9 3.1 1.8 -1.6 0.4
Verbal and Numeric Reasoning (VNR) 1.4 3.4 5.5 2.3 -2.1 -0.5
Breast Cancer 0.1 0.2 0.3 -0.4 -0.1 0.5
Ovarian Cancer 0.3 0.4 0.8 -0.9 0.7 -0.0
Prostate Cancer 0.7 1.0 1.3 -0.8 1.1 0.9
Age at First Birth 0.7 1.0 1.3 -1.0 1.1 -0.9
Bipolar Disorder (2011) 5.4 5.2 8.4 0.7 2.6 2.9
Body Mass Index (BMI) (2010) 0.4 0.6 1.6 -0.2 -1.3 -0.4
Coronary Artery Disease (CAD) 0.2 0.2 0.3 -0.5 -0.5 -0.6
Crohns Disease (2012) 0.1 0.2 0.4 -0.4 0.7 -0.2
Mean Putamen Volume 0.8 0.9 1.8 0.7 0.6 -1.4
Fasting Glucose 0.8 1.0 2.5 -1.6 0.3 0.7
HbA1C 0.6 0.6 0.9 -0.9 -0.4 -0.9
HDL Cholesterol 0.6 1.1 2.1 -1.0 1.4 -0.4
LDL Cholesterol 1.0 1.5 2.4 1.5 -1.5 0.2
Lupus 0.3 0.4 0.8 0.7 0.3 -0.9
Neuroticism (2016) 2.1 3.1 7.9 2.8 0.1 1.2
Primary Biliary Cirrhosis 0.2 0.2 0.7 0.0 -0.1 0.8
Rheumatoid Arthritis 0.9 1.2 3.0 -1.7 -0.7 -0.2
Schizophrenia (2014) 0.8 1.8 2.4 1.5 1.4 1.1
Triglycerides 0.7 1.2 2.9 1.7 -0.3 0.7
Type 2 Diabetes (T2D) (2012) 1.7 2.0 3.5 1.9 -1.5 0.3
Ulcerative Colitis 0.6 0.8 1.9 -1.4 0.7 0.4
Blood Eosinophil Count 0.1 0.8 1.9 -0.4 -0.5 -1.4
Blood Platelet Count 0.2 2.6 3.9 2.0 -1.2 -1.6
Blood Red Count 0.0 0.4 1.2 1.1 -0.3 0.3
Blood White Count 0.3 2.6 3.9 1.3 -1.5 -2.0
Heel T-Score 0.8 6.5 7.6 2.5 -2.8 2.4
BMI 0.8 4.8 7.1 1.2 -2.4 -2.7
Height 0.7 14.4 30.4 -2.8 -5.5 -2.3
Waist Hip Ratio (WHR) 0.3 1.2 3.2 1.8 0.5 0.4
Systolic Blood Pressure 0.2 0.8 2.0 1.4 0.0 0.7
Smoking Status 0.4 1.0 1.8 -1.3 1.1 0.3
Allergy or Eczema 1.0 2.6 5.0 -1.5 2.2 0.8
Cardiovascular Disease 0.7 2.4 5.5 2.3 -1.1 0.7
Hypothyroidism (self reported) 0.7 1.6 2.5 -1.4 0.7 1.6
Respiratory disease 0.8 1.8 5.3 2.3 0.2 -0.2
Type 2 Diabetes (T2D) (2018) 0.7 1.3 3.7 0.4 -1.9 -0.3
Lung FEV1/FVC ratio 0.7 3.3 8.6 -0.1 -2.9 -1.2
Lung FVC 2.0 10.3 22.4 -1.2 -2.7 -4.7
Neuroticism 0.3 0.7 0.9 0.8 -0.8 -1.0
Chronotype (morning person) 1.1 2.5 3.8 -1.8 -2.0 0.4
Hair Pigment 0.0 0.2 0.3 -0.6 -0.6 -0.0
Tanning 0.1 1.5 3.6 -1.9 0.0 0.9
Hand grip strength (left) 1.2 3.2 7.5 0.6 -1.3 -2.7
Number of treatments/medications taken 0.2 0.4 1.1 0.3 -0.3 1.1
Average weekly spirits intake 1.6 2.0 3.7 1.9 -1.2 -0.9
Sensitivity / hurt feelings 0.1 0.2 0.4 0.4 -0.6 0.3
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.7 -0.3 0.8 0.7
Hearing difficulty/problems: Yes 0.9 1.4 2.7 1.7 -0.9 -0.8
Relative age of first facial hair 0.6 1.3 2.0 -1.4 0.0 -1.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.4 0.7 -0.6 -1.2
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.6 1.2 0.1 1.6
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 1.1 -1.0 0.2
Systolic blood pressure, automated reading 0.6 1.7 3.5 0.9 1.0 1.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 0.7 0.7 -0.8 -0.8
Angina 0.2 0.2 0.6 0.2 -0.3 0.8
Medication for hormone replacement therapy 3.2 3.6 6.9 2.6 -2.0 -0.1
Vitamin and mineral supplements 0.5 0.7 2.0 0.3 -0.2 -1.4
Supplements: Zinc 1.0 1.0 1.9 -1.4 0.6 0.9
Medication: Co-codamol 0.3 0.3 0.9 -0.0 -1.0 -0.0
Medication: Metformin 0.3 0.4 0.5 0.6 -0.7 -0.6
Diabetes (father) 2.3 2.8 4.8 -0.5 -1.8 -2.2
Diabetes (mother) 1.1 1.4 3.3 0.2 -1.8 -1.0
Severe depression (siblings) 0.9 1.0 2.7 -1.7 0.3 0.5
Pack years adult smoking proportion 2.1 3.2 5.3 -2.3 1.5 1.4
Impedance of leg (right) 2.4 11.5 29.1 2.3 -5.4 -0.1
Leg fat-free mass (left) 0.7 3.6 8.5 -2.9 0.4 -1.5
Trunk fat percentage 2.4 9.6 20.5 2.0 -4.5 -2.1
Hand grip strength (right) 0.8 2.3 6.4 -0.1 -0.7 -2.5
Townsend deprivation index at recruitment 0.5 0.7 1.3 0.6 0.6 1.1
Current tobacco smoking 0.2 0.3 0.4 -0.5 0.5 -0.6
Average weekly fortified wine intake 0.1 0.1 0.2 -0.2 -0.5 0.1
Maternal smoking around birth 0.2 0.2 0.7 -0.1 0.8 0.0
Fed-up feelings 0.5 0.9 2.1 0.2 -1.5 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.2 0.4 -0.2 1.1
Relative age voice broke 0.0 0.1 0.2 0.1 -0.1 -0.5
Taking other prescription medications 0.6 1.0 2.9 1.7 -0.0 0.3
Age when periods started (menarche) 0.5 1.3 3.7 -1.9 0.4 0.0
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.2 1.5 -1.2 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 1.2 1.0 -1.0 1.1
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 0.0 0.1 -0.1
Qualifications: CSEs or equivalent 0.7 0.9 1.8 -1.0 1.3 0.2
Serious illness, injury or assault to yourself 0.4 0.5 1.5 1.2 0.2 0.1
High blood pressure 0.3 0.9 2.1 1.4 0.2 0.7
Hayfever, allergic rhinitis or eczema 0.9 1.9 2.9 -1.7 1.7 0.1
Multivitamins +/- minerals 1.4 1.8 2.4 -1.6 1.0 1.4
Stomach or abdominal pain in last month 0.3 0.3 0.9 0.9 0.3 -0.0
Supplements: Glucosamine 1.5 2.0 4.0 -2.0 -0.4 -1.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.6 -0.8 0.4 -0.6
Medication: Atenolol 2.5 3.1 4.7 0.1 2.1 2.2
Medication: Levothyroxine sodium 0.3 0.6 1.1 -0.5 0.7 1.0
Sitting height 0.7 5.2 8.7 -3.0 -2.4 -1.0
Chronic bronchitis/emphysema (father) 0.7 0.8 1.3 0.9 1.1 0.6
High blood pressure (mother) 1.6 2.2 6.1 -0.3 -2.5 -0.7
Body mass index (BMI) 0.5 2.2 3.4 1.2 -1.3 -1.8
Impedance of leg (left) 2.1 10.1 26.9 1.7 -5.2 -0.7
Leg predicted mass (left) 0.7 3.7 8.6 -2.9 0.3 -1.5
Trunk fat mass 1.9 8.3 17.5 1.1 -4.2 -2.5
Waist circumference 1.3 4.8 6.2 1.8 -2.5 -2.2
Number of incorrect matches in round 0.2 0.3 0.6 0.4 0.2 0.8
Past tobacco smoking 0.1 0.2 0.2 -0.4 0.5 0.3
Alcohol usually taken with meals 0.3 0.5 0.8 0.5 0.9 0.8
Nervous feelings 1.0 1.8 5.0 2.2 0.0 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.4 0.7 0.5 0.6
Hearing difficulty/problems with background noise 0.0 0.1 0.1 0.3 -0.3 0.2
Hair/balding pattern: Pattern 2 1.3 1.7 3.6 -1.9 -0.4 -1.2
Had menopause 0.7 0.8 1.7 1.3 0.6 0.6
Had other major operations 0.8 0.9 1.7 -1.3 -0.6 -0.9
Forced vital capacity (FVC) 2.0 7.6 11.2 -1.7 -2.9 -3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.6 -0.3 -0.5 0.8
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.7 0.8 0.5 0.8
Qualifications: None of the above 0.1 0.1 0.3 0.0 -0.6 0.2
Financial difficulties in last 2 years 1.0 1.3 2.2 -0.3 1.5 1.2
Mouth/teeth dental problems 0.1 0.2 0.4 -0.2 -0.7 -0.3
Heart attack 0.3 0.4 1.1 -1.0 0.3 0.2
Allergy 0.2 0.5 1.6 0.2 -1.2 0.1
Pain all over the body in last month 0.9 1.0 1.4 -0.9 -0.9 -1.2
Diabetes (self-reported) 0.3 0.5 1.0 -1.0 -0.7 0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.4 -0.3 -0.2 -1.2
Medication: Ramipril 1.0 1.3 1.8 0.9 -1.3 -1.1
Medication: Simvastatin 0.6 0.9 2.3 0.6 -0.0 1.5
Fluid intelligence score 1.5 3.0 5.0 2.2 -1.9 0.7
Illnesses of siblings 1.1 1.6 2.6 -1.6 1.4 0.5
Neuroticism score 0.1 0.3 0.3 0.5 -0.5 -0.5
Weight 1.1 5.4 8.0 -0.7 -2.8 -2.8
Impedance of arm (right) 0.9 4.2 9.2 1.7 -3.0 0.7
Arm fat percentage (right) 1.4 5.6 7.7 2.6 -2.8 -1.5
Trunk fat-free mass 0.8 4.6 9.9 -3.1 -0.3 -2.0
Hip circumference 1.9 8.2 15.8 0.8 -4.0 -2.9
Time employed in main current job 0.2 0.2 0.5 0.4 0.1 0.7
Alcohol intake versus 10 years previously 0.4 0.6 1.0 -0.8 -0.3 -1.0
Father’s age at death 0.5 0.7 1.8 0.2 1.3 -0.5
Worrier / anxious feelings 1.5 2.8 4.5 1.8 -2.1 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.3 -0.0 0.7
Falls in the last year 1.3 1.8 3.8 -1.9 -0.2 -1.3
Hair/balding pattern: Pattern 3 2.2 3.2 5.6 0.8 2.4 1.8
Number of live births 0.0 0.1 0.1 0.3 -0.0 0.2
Forced expiratory volume in 1-second (FEV1) 2.9 9.7 14.6 -1.3 -3.8 -3.6
Pulse rate 0.6 1.0 2.6 0.6 0.2 1.6
Happiness 0.2 0.2 0.3 -0.6 0.2 0.5
Noisy workplace 0.6 0.7 1.5 0.2 0.8 1.2
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.2 -0.0 -0.4 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 0.6 0.3 -0.1
Mouth/teeth dental problems: Dentures 1.4 2.4 5.8 -0.4 2.4 1.1
Asthma 0.7 1.5 4.0 2.0 0.5 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 3.3 -1.1 -1.8 -1.4
Medication: Cholesterol lowering 0.1 0.2 0.6 -0.1 -0.8 0.3
Depression (self-reported) 0.2 0.2 0.6 0.1 0.0 0.8
Medication: Lansoprazole 0.5 0.5 0.6 0.6 -0.8 -0.8
Prospective memory result 0.7 0.8 1.3 1.1 1.0 0.3
Lung cancer (father) 0.4 0.5 1.5 0.1 0.2 1.2
Illnesses of mother 0.6 0.8 1.9 -0.5 1.4 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.2 9.3 -1.9 -3.0 -3.1
Pulse wave Arterial Stiffness index 0.7 0.8 1.6 1.3 0.8 0.5
Impedance of arm (left) 0.8 3.6 9.8 0.9 -3.1 0.2
Arm fat mass (right) 1.1 4.5 7.7 1.4 -2.8 -2.0
Trunk predicted mass 0.8 4.5 9.8 -3.1 -0.2 -1.9
Standing height 1.2 12.1 19.1 -4.4 -3.3 -2.5
Length of working week for main job 1.9 2.1 3.4 -1.8 1.1 -1.3
Exposure to tobacco smoke at home 1.5 1.7 2.4 -0.9 1.3 1.5
Breastfed as a baby 0.6 0.8 2.1 0.4 -0.2 -1.4
Tense / ‘highly strung’ 0.3 0.6 1.2 1.1 0.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.6 1.6 -0.3 0.9
Hair/balding pattern: Pattern 4 0.8 2.0 4.3 0.4 -2.1 -1.3
Birth weight of first child 0.9 1.7 2.1 1.3 -1.1 -1.4
Peak expiratory flow (PEF) 1.0 2.3 3.3 -0.8 -1.7 -1.8
Pulse wave reflection index 0.1 0.2 0.3 0.3 -0.2 -0.6
Ever highly irritable/argumentative for 2 days 1.3 1.5 2.8 -0.7 1.1 1.7
Loud music exposure frequency 0.4 0.5 0.7 0.4 -0.7 -0.9
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.1 -0.6 0.5 1.1
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.4 0.3 0.1 -0.6
Blood clot in the leg (DVT) 0.6 0.7 1.7 -0.6 0.4 -1.3
Medication: Paracetamol 1.0 1.6 4.4 -2.1 0.2 -0.6
Headache pain in last month 0.6 1.1 1.9 1.1 -1.4 -0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.1 -0.5 -0.3 -1.0
Glaucoma (self-reported) 0.3 0.4 1.0 0.3 -0.1 1.0
Gout (self-reported) 0.2 0.2 0.4 0.2 0.7 -0.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.5 -0.8 0.9 1.2
Medication: Amlodipine 0.5 0.7 1.4 0.8 1.2 0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 1.2 0.1 0.1
Birth weight 2.0 4.3 6.4 -1.7 1.9 2.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.8 -0.7 0.9 0.7
High blood pressure (siblings) 0.3 0.4 0.6 0.8 -0.7 0.4
Forced vital capacity (FVC), Best measure 1.8 6.6 7.9 -2.7 -2.2 -2.8
Body fat percentage 2.4 9.6 19.0 2.1 -4.4 -2.3
Leg fat percentage (right) 2.9 10.4 17.6 3.1 -4.2 -2.0
Arm fat-free mass (right) 0.9 4.4 7.8 -2.8 -0.8 -2.2
Exposure to tobacco smoke outside home 0.5 0.7 1.2 0.5 0.8 1.1
Comparative body size at age 10 1.1 3.0 9.0 -0.1 -0.4 -3.0
Number of full brothers 0.2 0.3 0.7 0.2 0.1 -0.8
Worry too long after embarrassment 1.3 2.2 6.2 0.3 -2.5 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.8 0.4 0.3
Wheeze or whistling in the chest in last year 1.2 2.1 5.1 2.2 1.0 -0.3
Number of children fathered 1.2 1.3 2.2 -1.5 1.4 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.4 -0.4 -0.8 -1.6
Age at first live birth 0.3 0.5 0.7 -0.8 0.8 0.5
Pulse wave peak to peak time 1.0 1.2 2.6 -1.6 -0.9 -0.5
Health satisfaction 0.6 0.8 2.0 1.4 -0.5 -0.5
Shortness of breath walking on level ground 0.4 0.4 1.1 -0.2 0.4 -1.0
Qualifications: College or University degree 0.6 2.0 5.0 -1.0 -0.0 -2.2
Eye problems/disorders: None of the above 1.7 2.0 3.3 0.8 -1.8 -1.4
Mouth/teeth dental problems: Loose teeth 1.4 1.7 4.0 2.0 0.0 1.0
Emphysema/chronic bronchitis 1.1 1.2 3.4 1.8 -0.5 0.2
Medication for pain relief, constipation, heartburn 0.7 1.2 2.0 0.3 1.2 1.4
Neck or shoulder pain in last month 0.4 0.6 1.4 -0.2 0.5 -1.2
Medication: Blood pressure 0.3 0.5 0.9 1.0 -0.2 0.6
Angina (self-reported) 0.1 0.1 0.3 0.3 -0.2 0.5
Migraine (self-reported) 1.5 1.9 3.1 1.0 -1.8 -1.3
Medication: Ibuprofen 2.8 3.4 4.6 -1.1 -2.0 -2.1
Medication: Allopurinol 0.1 0.1 0.2 0.0 0.2 -0.5
Medication: Omeprazole 0.1 0.1 0.2 0.2 -0.5 -0.3
Medication: Seretide 50 evohaler 0.3 0.3 0.6 0.6 -0.7 0.1
Mean time to correctly identify matches 1.1 2.1 4.8 2.2 -1.2 -0.0
Heart disease (mother) 0.5 0.6 1.3 1.1 -0.5 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 0.0 0.2 -0.7
Whole body fat mass 1.6 6.6 13.8 0.9 -3.7 -2.3
Leg fat mass (right) 1.5 5.9 11.6 1.2 -3.4 -2.1
Arm predicted mass (right) 0.7 3.8 8.2 -2.9 -0.4 -1.8
Pulse rate, automated reading 0.8 2.7 6.4 2.5 0.6 1.1
Alcohol intake frequency. 0.4 0.9 2.8 1.7 0.2 0.1
Comparative height size at age 10 1.4 7.4 9.1 -2.7 -3.0 -2.4
Number of full sisters 2.5 3.1 5.3 -0.7 2.3 1.9
Suffer from ‘nerves’ 0.3 0.4 0.8 0.9 -0.5 -0.5
Overall health rating 0.8 1.6 4.3 2.1 -0.8 0.0
Chest pain or discomfort 0.7 1.0 2.8 0.3 0.3 1.7
Had major operations 0.8 0.9 2.1 0.7 -1.5 -0.2
Age at last live birth 0.5 0.7 1.0 -0.9 1.0 -0.3
Family relationship satisfaction 1.1 1.3 2.1 -1.4 1.2 0.7
Leg pain on walking 1.7 2.1 5.7 2.4 0.8 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 -0.7 -0.5 -1.0
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.2 -0.5 0.1
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.3 -1.8 1.2 0.1
Medication: Aspirin 0.3 0.4 0.6 0.7 0.4 0.6
Supplements: Vitamin C 0.3 0.4 0.6 0.7 -0.8 -0.3
Knee pain experienced in last month 0.1 0.1 0.3 0.1 0.5 -0.0
Hypertension (Self-reported) 0.4 1.1 2.8 1.7 0.1 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 -0.6 -0.3 -1.0
Illnesses of father: Heart disease 0.3 0.4 0.5 0.7 -0.7 -0.5
Illnesses of siblings: Diabetes 0.8 0.9 2.1 -0.3 -0.8 -1.5
Smoking status: Previous 0.5 0.8 1.3 0.9 -1.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.8 -0.5 -0.9 0.3
Whole body fat-free mass 0.8 4.5 10.0 -3.2 0.1 -1.9
Leg fat-free mass (right) 0.8 4.5 10.1 -3.2 0.7 -1.7
Arm fat percentage (left) 1.2 4.8 7.1 2.2 -2.7 -1.6
Average weekly red wine intake 0.4 0.6 1.1 1.0 -0.9 -0.2
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.1 -1.4 -0.4 -1.4
Mood swings 0.1 0.2 0.5 -0.7 -0.2 0.2
Loneliness, isolation 0.3 0.5 0.6 -0.5 -0.8 -0.8
Long-standing illness, disability or infirmity 1.0 1.5 2.3 1.5 -0.2 1.5
Ever had bowel cancer screening 1.2 1.4 4.1 2.0 -0.4 -0.2
Diabetes diagnosed by doctor 0.3 0.5 1.0 -0.1 -1.0 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.9 -0.4 1.7 -0.1
Friendships satisfaction 0.1 0.2 0.4 0.6 0.0 0.4
Qualifications: nursing, teaching 1.1 1.6 2.8 -0.6 -1.7 -1.3
Commuting to job workplace: Walk 0.6 0.7 1.2 -0.9 1.1 0.1
Eye problems/disorders: Cataract 1.3 1.6 2.1 -1.3 1.4 0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 -0.0 -0.6 0.3
Medication for cholesterol 2.4 3.6 8.6 -2.9 1.3 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.6 0.1 -0.1 -1.2
Back pain experienced in last month 1.1 1.6 2.2 -0.9 -1.5 -1.3
Mineral and other dietary supplements 0.7 0.9 2.1 0.6 -0.5 -1.5
Breast cancer (self-reported) 3.6 4.3 7.7 -0.2 2.8 2.3
Asthma (self-reported) 0.8 1.5 4.2 2.0 0.4 -0.6
Osteoporosis (self-reported) 0.3 0.3 0.6 0.6 0.8 0.2
Osteoarthritis (self-reported) 1.2 1.5 2.8 -1.3 -0.0 -1.7
Medication: Aspirin 0.4 0.6 1.0 0.5 0.7 1.0
Medication: Gliclazide 0.3 0.4 0.6 -0.2 -0.7 -0.8
Illnesses of father: None of the above (group 1) 1.5 1.8 2.8 -1.2 1.7 1.2
Smoking status: Current 0.2 0.4 0.7 -0.5 0.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 5.0 0.8 -2.2 -1.4
Whole body water mass 0.7 4.0 8.6 -2.9 -0.0 -1.8
Leg predicted mass (right) 0.8 4.5 10.3 -3.2 0.7 -1.6
Arm fat mass (left) 0.9 3.8 6.8 0.9 -2.6 -1.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 0.7 0.4 0.1
Average weekly champagne plus white wine intake 0.3 0.4 1.0 -0.1 -1.0 -0.3
Miserableness 0.1 0.2 0.4 0.0 -0.5 0.6
Guilty feelings 1.7 2.5 4.4 0.2 -2.1 -1.8
Wears glasses or contact lenses 0.1 0.1 0.2 -0.3 -0.0 0.5
Ever taken oral contraceptive pill 1.1 1.2 2.0 1.3 -0.3 1.4
Hearing aid user 2.2 2.4 2.9 1.3 -1.7 -1.7
Mother’s age at death 0.7 0.9 2.5 -1.6 0.4 -0.3
Financial situation satisfaction 0.3 0.4 1.0 -0.2 1.0 -0.3
Tinnitus: Yes, now most or all of the time 2.5 2.9 4.7 0.3 2.2 2.0
Commuting to job workplace: Public transport 0.2 0.3 0.4 0.7 -0.5 -0.4
Eye problems/disorders: Glaucoma 0.4 0.5 0.6 -0.4 0.8 0.8
Medication: Blood pressure 1.2 2.3 5.4 2.3 -0.7 1.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.1 0.3 -0.2 -0.3
Supplements: Fish oil (including cod liver oil) 2.1 2.8 4.8 -1.6 0.9 2.2
High cholesterol (Self-reported) 0.2 0.3 0.7 -0.1 -0.5 0.8
Medication: Bendroflumethiazide 1.0 1.6 3.4 1.8 -0.1 1.1
Medication: Paracetamol 0.8 1.3 3.4 -1.8 0.2 -0.6
Medication: Lisinopril 0.1 0.2 0.4 -0.4 -0.6 -0.2
Medication: Atorvastatin 0.2 0.2 0.6 0.8 -0.1 0.1
Illnesses of father: High blood pressure 0.3 0.4 0.5 -0.6 -0.7 0.4
Alcohol drinker status: Never 0.9 1.1 1.6 1.3 -0.8 -1.0
Ever smoked 0.1 0.1 0.3 -0.1 -0.5 0.2
Basal metabolic rate 0.7 4.0 6.8 -2.6 -0.7 -2.2
Leg fat percentage (left) 2.7 9.6 16.2 2.5 -4.0 -2.5
Arm fat-free mass (left) 0.8 4.0 6.9 -2.6 -0.7 -2.1
Number of operations (self-reported) 0.2 0.4 0.8 0.1 -0.9 0.5
Average weekly beer plus cider intake 0.9 1.4 2.0 -1.4 1.4 0.5
Irritability 1.4 2.4 3.4 -1.1 1.8 1.6
Risk taking 0.8 1.1 1.8 -1.3 1.4 0.2
Ever had prostate specific antigen (PSA) test 0.9 1.1 1.8 -1.4 0.2 -1.1
Fractured/broken bones in last 5 years 0.8 1.0 1.4 -1.2 -0.7 -1.1
Age started oral contraceptive pill 0.2 0.3 0.6 0.5 0.1 0.8
Diastolic blood pressure, automated reading 0.3 0.9 2.0 0.5 0.6 1.4
Ever depressed for a whole week 0.6 0.8 1.2 1.1 0.7 0.8
Unable to work because of sickness or disability 1.2 1.5 2.4 0.8 -1.5 -1.3
Commuting to job workplace: Cycle 2.5 3.1 5.6 -2.4 1.9 -0.2
Myopia 0.3 0.4 0.7 0.7 -0.9 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.0 -1.4 -0.5 -1.0
Cholesterol lowering medication 0.6 0.9 1.5 1.2 -0.0 1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 0.0 -0.3 -1.0
Pain experienced in last month 0.8 1.3 2.4 0.8 0.9 1.6
Supplements: Calcium 0.3 0.4 0.7 -0.8 0.6 0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.5 -0.2 -0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 -1.2 0.3 0.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.6 -0.7 0.3 -1.6
Heart disease (siblings) 0.4 0.5 0.8 0.9 0.4 -0.8
Alcohol drinker status: Previous 1.7 1.9 2.8 1.4 -1.7 -1.0
Pack years of smoking 1.8 2.7 4.9 -2.2 1.0 1.4
Impedance of whole body 1.4 6.9 19.4 1.2 -4.4 -0.1
Leg fat mass (left) 1.5 5.8 10.9 0.9 -3.3 -2.4
Arm predicted mass (left) 0.6 3.0 4.7 -2.2 -0.8 -1.9