Hub : Genes

SEC11A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2680	0.0990	7.5e-03	0.091	NA	0.000	NA	0.108	7.0e-04	NA	3.2e-01	NA	2.2e-04
2	METSIM	Adipose	0.0494	0.0213	8.8e-04	0.008	0.018	0.026	0.020	0.008	2.0e-02	8.1e-04	7.9e-05	0.00041	1.8e-02
3	YFS	Blood	0.0192	0.0075	4.4e-05	0.014	0.013	0.018	0.014	0.017	1.5e-05	3.2e-05	9.3e-07	0.00002	1.5e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.2	1.1	0.6	0.2
Bipolar Disorder or Schizophrenia	1.1	2.7	4.3	2.1	1.6	1.1
Depressed Affect (Nagel 2018)	0.6	1.3	2.2	-0.4	-1.5	-1.2
Depression (Nagel 2018)	0.1	0.1	0.2	0.3	-0.4	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	0.8	-1.2	-0.1
Neuroticism (Nagel 2018)	0.7	1.6	2.9	1.1	-1.7	-0.8
Schizophrenia (2018)	1.1	2.4	3.2	1.8	1.6	1.2
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	1.2	-0.4	0.9
Worry (Nagel 2018)	1.0	2.1	4.8	2.2	-1.2	-0.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.2	1.1	0.3	1.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.2	2.7	1.7	0.3	0.9
Crohns Disease (2017)	0.2	0.5	1.0	-0.7	0.2	-1.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	-1.9	0.0	-1.2
Ulcerative Colitis (UC)	0.9	1.7	3.0	-1.7	-0.8	-1.2
Major Depression (MDD)	0.1	0.1	0.2	0.5	-0.3	0.2
Reaction Time	1.0	1.9	3.1	1.8	-1.6	0.4
Verbal and Numeric Reasoning (VNR)	1.4	3.4	5.5	2.3	-2.1	-0.5
Breast Cancer	0.1	0.2	0.3	-0.4	-0.1	0.5
Ovarian Cancer	0.3	0.4	0.8	-0.9	0.7	-0.0
Prostate Cancer	0.7	1.0	1.3	-0.8	1.1	0.9
Age at First Birth	0.7	1.0	1.3	-1.0	1.1	-0.9
Bipolar Disorder (2011)	5.4	5.2	8.4	0.7	2.6	2.9
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	-0.2	-1.3	-0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.5	-0.5	-0.6
Crohns Disease (2012)	0.1	0.2	0.4	-0.4	0.7	-0.2
Mean Putamen Volume	0.8	0.9	1.8	0.7	0.6	-1.4
Fasting Glucose	0.8	1.0	2.5	-1.6	0.3	0.7
HbA1C	0.6	0.6	0.9	-0.9	-0.4	-0.9
HDL Cholesterol	0.6	1.1	2.1	-1.0	1.4	-0.4
LDL Cholesterol	1.0	1.5	2.4	1.5	-1.5	0.2
Lupus	0.3	0.4	0.8	0.7	0.3	-0.9
Neuroticism (2016)	2.1	3.1	7.9	2.8	0.1	1.2
Primary Biliary Cirrhosis	0.2	0.2	0.7	0.0	-0.1	0.8
Rheumatoid Arthritis	0.9	1.2	3.0	-1.7	-0.7	-0.2
Schizophrenia (2014)	0.8	1.8	2.4	1.5	1.4	1.1
Triglycerides	0.7	1.2	2.9	1.7	-0.3	0.7
Type 2 Diabetes (T2D) (2012)	1.7	2.0	3.5	1.9	-1.5	0.3
Ulcerative Colitis	0.6	0.8	1.9	-1.4	0.7	0.4
Blood Eosinophil Count	0.1	0.8	1.9	-0.4	-0.5	-1.4
Blood Platelet Count	0.2	2.6	3.9	2.0	-1.2	-1.6
Blood Red Count	0.0	0.4	1.2	1.1	-0.3	0.3
Blood White Count	0.3	2.6	3.9	1.3	-1.5	-2.0
Heel T-Score	0.8	6.5	7.6	2.5	-2.8	2.4
BMI	0.8	4.8	7.1	1.2	-2.4	-2.7
Height	0.7	14.4	30.4	-2.8	-5.5	-2.3
Waist Hip Ratio (WHR)	0.3	1.2	3.2	1.8	0.5	0.4
Systolic Blood Pressure	0.2	0.8	2.0	1.4	0.0	0.7
Smoking Status	0.4	1.0	1.8	-1.3	1.1	0.3
Allergy or Eczema	1.0	2.6	5.0	-1.5	2.2	0.8
Cardiovascular Disease	0.7	2.4	5.5	2.3	-1.1	0.7
Hypothyroidism (self reported)	0.7	1.6	2.5	-1.4	0.7	1.6
Respiratory disease	0.8	1.8	5.3	2.3	0.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.7	0.4	-1.9	-0.3
Lung FEV1/FVC ratio	0.7	3.3	8.6	-0.1	-2.9	-1.2
Lung FVC	2.0	10.3	22.4	-1.2	-2.7	-4.7
Neuroticism	0.3	0.7	0.9	0.8	-0.8	-1.0
Chronotype (morning person)	1.1	2.5	3.8	-1.8	-2.0	0.4
Hair Pigment	0.0	0.2	0.3	-0.6	-0.6	-0.0
Tanning	0.1	1.5	3.6	-1.9	0.0	0.9
Hand grip strength (left)	1.2	3.2	7.5	0.6	-1.3	-2.7
Number of treatments/medications taken	0.2	0.4	1.1	0.3	-0.3	1.1
Average weekly spirits intake	1.6	2.0	3.7	1.9	-1.2	-0.9
Sensitivity / hurt feelings	0.1	0.2	0.4	0.4	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.3	0.8	0.7
Hearing difficulty/problems: Yes	0.9	1.4	2.7	1.7	-0.9	-0.8
Relative age of first facial hair	0.6	1.3	2.0	-1.4	0.0	-1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	0.7	-0.6	-1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	1.2	0.1	1.6
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	1.1	-1.0	0.2
Systolic blood pressure, automated reading	0.6	1.7	3.5	0.9	1.0	1.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.7	0.7	-0.8	-0.8
Angina	0.2	0.2	0.6	0.2	-0.3	0.8
Medication for hormone replacement therapy	3.2	3.6	6.9	2.6	-2.0	-0.1
Vitamin and mineral supplements	0.5	0.7	2.0	0.3	-0.2	-1.4
Supplements: Zinc	1.0	1.0	1.9	-1.4	0.6	0.9
Medication: Co-codamol	0.3	0.3	0.9	-0.0	-1.0	-0.0
Medication: Metformin	0.3	0.4	0.5	0.6	-0.7	-0.6
Diabetes (father)	2.3	2.8	4.8	-0.5	-1.8	-2.2
Diabetes (mother)	1.1	1.4	3.3	0.2	-1.8	-1.0
Severe depression (siblings)	0.9	1.0	2.7	-1.7	0.3	0.5
Pack years adult smoking proportion	2.1	3.2	5.3	-2.3	1.5	1.4
Impedance of leg (right)	2.4	11.5	29.1	2.3	-5.4	-0.1
Leg fat-free mass (left)	0.7	3.6	8.5	-2.9	0.4	-1.5
Trunk fat percentage	2.4	9.6	20.5	2.0	-4.5	-2.1
Hand grip strength (right)	0.8	2.3	6.4	-0.1	-0.7	-2.5
Townsend deprivation index at recruitment	0.5	0.7	1.3	0.6	0.6	1.1
Current tobacco smoking	0.2	0.3	0.4	-0.5	0.5	-0.6
Average weekly fortified wine intake	0.1	0.1	0.2	-0.2	-0.5	0.1
Maternal smoking around birth	0.2	0.2	0.7	-0.1	0.8	0.0
Fed-up feelings	0.5	0.9	2.1	0.2	-1.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.4	-0.2	1.1
Relative age voice broke	0.0	0.1	0.2	0.1	-0.1	-0.5
Taking other prescription medications	0.6	1.0	2.9	1.7	-0.0	0.3
Age when periods started (menarche)	0.5	1.3	3.7	-1.9	0.4	0.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.2	1.5	-1.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.2	1.0	-1.0	1.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.0	0.1	-0.1
Qualifications: CSEs or equivalent	0.7	0.9	1.8	-1.0	1.3	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.5	1.2	0.2	0.1
High blood pressure	0.3	0.9	2.1	1.4	0.2	0.7
Hayfever, allergic rhinitis or eczema	0.9	1.9	2.9	-1.7	1.7	0.1
Multivitamins +/- minerals	1.4	1.8	2.4	-1.6	1.0	1.4
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.9	0.3	-0.0
Supplements: Glucosamine	1.5	2.0	4.0	-2.0	-0.4	-1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	-0.8	0.4	-0.6
Medication: Atenolol	2.5	3.1	4.7	0.1	2.1	2.2
Medication: Levothyroxine sodium	0.3	0.6	1.1	-0.5	0.7	1.0
Sitting height	0.7	5.2	8.7	-3.0	-2.4	-1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	0.9	1.1	0.6
High blood pressure (mother)	1.6	2.2	6.1	-0.3	-2.5	-0.7
Body mass index (BMI)	0.5	2.2	3.4	1.2	-1.3	-1.8
Impedance of leg (left)	2.1	10.1	26.9	1.7	-5.2	-0.7
Leg predicted mass (left)	0.7	3.7	8.6	-2.9	0.3	-1.5
Trunk fat mass	1.9	8.3	17.5	1.1	-4.2	-2.5
Waist circumference	1.3	4.8	6.2	1.8	-2.5	-2.2
Number of incorrect matches in round	0.2	0.3	0.6	0.4	0.2	0.8
Past tobacco smoking	0.1	0.2	0.2	-0.4	0.5	0.3
Alcohol usually taken with meals	0.3	0.5	0.8	0.5	0.9	0.8
Nervous feelings	1.0	1.8	5.0	2.2	0.0	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.4	0.7	0.5	0.6
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.3	-0.3	0.2
Hair/balding pattern: Pattern 2	1.3	1.7	3.6	-1.9	-0.4	-1.2
Had menopause	0.7	0.8	1.7	1.3	0.6	0.6
Had other major operations	0.8	0.9	1.7	-1.3	-0.6	-0.9
Forced vital capacity (FVC)	2.0	7.6	11.2	-1.7	-2.9	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.3	-0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	0.8	0.5	0.8
Qualifications: None of the above	0.1	0.1	0.3	0.0	-0.6	0.2
Financial difficulties in last 2 years	1.0	1.3	2.2	-0.3	1.5	1.2
Mouth/teeth dental problems	0.1	0.2	0.4	-0.2	-0.7	-0.3
Heart attack	0.3	0.4	1.1	-1.0	0.3	0.2
Allergy	0.2	0.5	1.6	0.2	-1.2	0.1
Pain all over the body in last month	0.9	1.0	1.4	-0.9	-0.9	-1.2
Diabetes (self-reported)	0.3	0.5	1.0	-1.0	-0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.3	-0.2	-1.2
Medication: Ramipril	1.0	1.3	1.8	0.9	-1.3	-1.1
Medication: Simvastatin	0.6	0.9	2.3	0.6	-0.0	1.5
Fluid intelligence score	1.5	3.0	5.0	2.2	-1.9	0.7
Illnesses of siblings	1.1	1.6	2.6	-1.6	1.4	0.5
Neuroticism score	0.1	0.3	0.3	0.5	-0.5	-0.5
Weight	1.1	5.4	8.0	-0.7	-2.8	-2.8
Impedance of arm (right)	0.9	4.2	9.2	1.7	-3.0	0.7
Arm fat percentage (right)	1.4	5.6	7.7	2.6	-2.8	-1.5
Trunk fat-free mass	0.8	4.6	9.9	-3.1	-0.3	-2.0
Hip circumference	1.9	8.2	15.8	0.8	-4.0	-2.9
Time employed in main current job	0.2	0.2	0.5	0.4	0.1	0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.0	-0.8	-0.3	-1.0
Father’s age at death	0.5	0.7	1.8	0.2	1.3	-0.5
Worrier / anxious feelings	1.5	2.8	4.5	1.8	-2.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	-0.0	0.7
Falls in the last year	1.3	1.8	3.8	-1.9	-0.2	-1.3
Hair/balding pattern: Pattern 3	2.2	3.2	5.6	0.8	2.4	1.8
Number of live births	0.0	0.1	0.1	0.3	-0.0	0.2
Forced expiratory volume in 1-second (FEV1)	2.9	9.7	14.6	-1.3	-3.8	-3.6
Pulse rate	0.6	1.0	2.6	0.6	0.2	1.6
Happiness	0.2	0.2	0.3	-0.6	0.2	0.5
Noisy workplace	0.6	0.7	1.5	0.2	0.8	1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.0	-0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	0.6	0.3	-0.1
Mouth/teeth dental problems: Dentures	1.4	2.4	5.8	-0.4	2.4	1.1
Asthma	0.7	1.5	4.0	2.0	0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	3.3	-1.1	-1.8	-1.4
Medication: Cholesterol lowering	0.1	0.2	0.6	-0.1	-0.8	0.3
Depression (self-reported)	0.2	0.2	0.6	0.1	0.0	0.8
Medication: Lansoprazole	0.5	0.5	0.6	0.6	-0.8	-0.8
Prospective memory result	0.7	0.8	1.3	1.1	1.0	0.3
Lung cancer (father)	0.4	0.5	1.5	0.1	0.2	1.2
Illnesses of mother	0.6	0.8	1.9	-0.5	1.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.2	9.3	-1.9	-3.0	-3.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	1.3	0.8	0.5
Impedance of arm (left)	0.8	3.6	9.8	0.9	-3.1	0.2
Arm fat mass (right)	1.1	4.5	7.7	1.4	-2.8	-2.0
Trunk predicted mass	0.8	4.5	9.8	-3.1	-0.2	-1.9
Standing height	1.2	12.1	19.1	-4.4	-3.3	-2.5
Length of working week for main job	1.9	2.1	3.4	-1.8	1.1	-1.3
Exposure to tobacco smoke at home	1.5	1.7	2.4	-0.9	1.3	1.5
Breastfed as a baby	0.6	0.8	2.1	0.4	-0.2	-1.4
Tense / ‘highly strung’	0.3	0.6	1.2	1.1	0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.6	1.6	-0.3	0.9
Hair/balding pattern: Pattern 4	0.8	2.0	4.3	0.4	-2.1	-1.3
Birth weight of first child	0.9	1.7	2.1	1.3	-1.1	-1.4
Peak expiratory flow (PEF)	1.0	2.3	3.3	-0.8	-1.7	-1.8
Pulse wave reflection index	0.1	0.2	0.3	0.3	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.8	-0.7	1.1	1.7
Loud music exposure frequency	0.4	0.5	0.7	0.4	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.6	0.5	1.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.3	0.1	-0.6
Blood clot in the leg (DVT)	0.6	0.7	1.7	-0.6	0.4	-1.3
Medication: Paracetamol	1.0	1.6	4.4	-2.1	0.2	-0.6
Headache pain in last month	0.6	1.1	1.9	1.1	-1.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.5	-0.3	-1.0
Glaucoma (self-reported)	0.3	0.4	1.0	0.3	-0.1	1.0
Gout (self-reported)	0.2	0.2	0.4	0.2	0.7	-0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.5	-0.8	0.9	1.2
Medication: Amlodipine	0.5	0.7	1.4	0.8	1.2	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	1.2	0.1	0.1
Birth weight	2.0	4.3	6.4	-1.7	1.9	2.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.8	-0.7	0.9	0.7
High blood pressure (siblings)	0.3	0.4	0.6	0.8	-0.7	0.4
Forced vital capacity (FVC), Best measure	1.8	6.6	7.9	-2.7	-2.2	-2.8
Body fat percentage	2.4	9.6	19.0	2.1	-4.4	-2.3
Leg fat percentage (right)	2.9	10.4	17.6	3.1	-4.2	-2.0
Arm fat-free mass (right)	0.9	4.4	7.8	-2.8	-0.8	-2.2
Exposure to tobacco smoke outside home	0.5	0.7	1.2	0.5	0.8	1.1
Comparative body size at age 10	1.1	3.0	9.0	-0.1	-0.4	-3.0
Number of full brothers	0.2	0.3	0.7	0.2	0.1	-0.8
Worry too long after embarrassment	1.3	2.2	6.2	0.3	-2.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	0.4	0.3
Wheeze or whistling in the chest in last year	1.2	2.1	5.1	2.2	1.0	-0.3
Number of children fathered	1.2	1.3	2.2	-1.5	1.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.4	-0.4	-0.8	-1.6
Age at first live birth	0.3	0.5	0.7	-0.8	0.8	0.5
Pulse wave peak to peak time	1.0	1.2	2.6	-1.6	-0.9	-0.5
Health satisfaction	0.6	0.8	2.0	1.4	-0.5	-0.5
Shortness of breath walking on level ground	0.4	0.4	1.1	-0.2	0.4	-1.0
Qualifications: College or University degree	0.6	2.0	5.0	-1.0	-0.0	-2.2
Eye problems/disorders: None of the above	1.7	2.0	3.3	0.8	-1.8	-1.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.0	2.0	0.0	1.0
Emphysema/chronic bronchitis	1.1	1.2	3.4	1.8	-0.5	0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	0.3	1.2	1.4
Neck or shoulder pain in last month	0.4	0.6	1.4	-0.2	0.5	-1.2
Medication: Blood pressure	0.3	0.5	0.9	1.0	-0.2	0.6
Angina (self-reported)	0.1	0.1	0.3	0.3	-0.2	0.5
Migraine (self-reported)	1.5	1.9	3.1	1.0	-1.8	-1.3
Medication: Ibuprofen	2.8	3.4	4.6	-1.1	-2.0	-2.1
Medication: Allopurinol	0.1	0.1	0.2	0.0	0.2	-0.5
Medication: Omeprazole	0.1	0.1	0.2	0.2	-0.5	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.6	-0.7	0.1
Mean time to correctly identify matches	1.1	2.1	4.8	2.2	-1.2	-0.0
Heart disease (mother)	0.5	0.6	1.3	1.1	-0.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.0	0.2	-0.7
Whole body fat mass	1.6	6.6	13.8	0.9	-3.7	-2.3
Leg fat mass (right)	1.5	5.9	11.6	1.2	-3.4	-2.1
Arm predicted mass (right)	0.7	3.8	8.2	-2.9	-0.4	-1.8
Pulse rate, automated reading	0.8	2.7	6.4	2.5	0.6	1.1
Alcohol intake frequency.	0.4	0.9	2.8	1.7	0.2	0.1
Comparative height size at age 10	1.4	7.4	9.1	-2.7	-3.0	-2.4
Number of full sisters	2.5	3.1	5.3	-0.7	2.3	1.9
Suffer from ‘nerves’	0.3	0.4	0.8	0.9	-0.5	-0.5
Overall health rating	0.8	1.6	4.3	2.1	-0.8	0.0
Chest pain or discomfort	0.7	1.0	2.8	0.3	0.3	1.7
Had major operations	0.8	0.9	2.1	0.7	-1.5	-0.2
Age at last live birth	0.5	0.7	1.0	-0.9	1.0	-0.3
Family relationship satisfaction	1.1	1.3	2.1	-1.4	1.2	0.7
Leg pain on walking	1.7	2.1	5.7	2.4	0.8	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.7	-0.5	-1.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.2	-0.5	0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	-1.8	1.2	0.1
Medication: Aspirin	0.3	0.4	0.6	0.7	0.4	0.6
Supplements: Vitamin C	0.3	0.4	0.6	0.7	-0.8	-0.3
Knee pain experienced in last month	0.1	0.1	0.3	0.1	0.5	-0.0
Hypertension (Self-reported)	0.4	1.1	2.8	1.7	0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.6	-0.3	-1.0
Illnesses of father: Heart disease	0.3	0.4	0.5	0.7	-0.7	-0.5
Illnesses of siblings: Diabetes	0.8	0.9	2.1	-0.3	-0.8	-1.5
Smoking status: Previous	0.5	0.8	1.3	0.9	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	-0.5	-0.9	0.3
Whole body fat-free mass	0.8	4.5	10.0	-3.2	0.1	-1.9
Leg fat-free mass (right)	0.8	4.5	10.1	-3.2	0.7	-1.7
Arm fat percentage (left)	1.2	4.8	7.1	2.2	-2.7	-1.6
Average weekly red wine intake	0.4	0.6	1.1	1.0	-0.9	-0.2
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.1	-1.4	-0.4	-1.4
Mood swings	0.1	0.2	0.5	-0.7	-0.2	0.2
Loneliness, isolation	0.3	0.5	0.6	-0.5	-0.8	-0.8
Long-standing illness, disability or infirmity	1.0	1.5	2.3	1.5	-0.2	1.5
Ever had bowel cancer screening	1.2	1.4	4.1	2.0	-0.4	-0.2
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.1	-1.0	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.9	-0.4	1.7	-0.1
Friendships satisfaction	0.1	0.2	0.4	0.6	0.0	0.4
Qualifications: nursing, teaching	1.1	1.6	2.8	-0.6	-1.7	-1.3
Commuting to job workplace: Walk	0.6	0.7	1.2	-0.9	1.1	0.1
Eye problems/disorders: Cataract	1.3	1.6	2.1	-1.3	1.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	-0.0	-0.6	0.3
Medication for cholesterol	2.4	3.6	8.6	-2.9	1.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	0.1	-0.1	-1.2
Back pain experienced in last month	1.1	1.6	2.2	-0.9	-1.5	-1.3
Mineral and other dietary supplements	0.7	0.9	2.1	0.6	-0.5	-1.5
Breast cancer (self-reported)	3.6	4.3	7.7	-0.2	2.8	2.3
Asthma (self-reported)	0.8	1.5	4.2	2.0	0.4	-0.6
Osteoporosis (self-reported)	0.3	0.3	0.6	0.6	0.8	0.2
Osteoarthritis (self-reported)	1.2	1.5	2.8	-1.3	-0.0	-1.7
Medication: Aspirin	0.4	0.6	1.0	0.5	0.7	1.0
Medication: Gliclazide	0.3	0.4	0.6	-0.2	-0.7	-0.8
Illnesses of father: None of the above (group 1)	1.5	1.8	2.8	-1.2	1.7	1.2
Smoking status: Current	0.2	0.4	0.7	-0.5	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.0	0.8	-2.2	-1.4
Whole body water mass	0.7	4.0	8.6	-2.9	-0.0	-1.8
Leg predicted mass (right)	0.8	4.5	10.3	-3.2	0.7	-1.6
Arm fat mass (left)	0.9	3.8	6.8	0.9	-2.6	-1.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.7	0.4	0.1
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-0.1	-1.0	-0.3
Miserableness	0.1	0.2	0.4	0.0	-0.5	0.6
Guilty feelings	1.7	2.5	4.4	0.2	-2.1	-1.8
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	-0.0	0.5
Ever taken oral contraceptive pill	1.1	1.2	2.0	1.3	-0.3	1.4
Hearing aid user	2.2	2.4	2.9	1.3	-1.7	-1.7
Mother’s age at death	0.7	0.9	2.5	-1.6	0.4	-0.3
Financial situation satisfaction	0.3	0.4	1.0	-0.2	1.0	-0.3
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.7	0.3	2.2	2.0
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.7	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	0.6	-0.4	0.8	0.8
Medication: Blood pressure	1.2	2.3	5.4	2.3	-0.7	1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.3	-0.2	-0.3
Supplements: Fish oil (including cod liver oil)	2.1	2.8	4.8	-1.6	0.9	2.2
High cholesterol (Self-reported)	0.2	0.3	0.7	-0.1	-0.5	0.8
Medication: Bendroflumethiazide	1.0	1.6	3.4	1.8	-0.1	1.1
Medication: Paracetamol	0.8	1.3	3.4	-1.8	0.2	-0.6
Medication: Lisinopril	0.1	0.2	0.4	-0.4	-0.6	-0.2
Medication: Atorvastatin	0.2	0.2	0.6	0.8	-0.1	0.1
Illnesses of father: High blood pressure	0.3	0.4	0.5	-0.6	-0.7	0.4
Alcohol drinker status: Never	0.9	1.1	1.6	1.3	-0.8	-1.0
Ever smoked	0.1	0.1	0.3	-0.1	-0.5	0.2
Basal metabolic rate	0.7	4.0	6.8	-2.6	-0.7	-2.2
Leg fat percentage (left)	2.7	9.6	16.2	2.5	-4.0	-2.5
Arm fat-free mass (left)	0.8	4.0	6.9	-2.6	-0.7	-2.1
Number of operations (self-reported)	0.2	0.4	0.8	0.1	-0.9	0.5
Average weekly beer plus cider intake	0.9	1.4	2.0	-1.4	1.4	0.5
Irritability	1.4	2.4	3.4	-1.1	1.8	1.6
Risk taking	0.8	1.1	1.8	-1.3	1.4	0.2
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.8	-1.4	0.2	-1.1
Fractured/broken bones in last 5 years	0.8	1.0	1.4	-1.2	-0.7	-1.1
Age started oral contraceptive pill	0.2	0.3	0.6	0.5	0.1	0.8
Diastolic blood pressure, automated reading	0.3	0.9	2.0	0.5	0.6	1.4
Ever depressed for a whole week	0.6	0.8	1.2	1.1	0.7	0.8
Unable to work because of sickness or disability	1.2	1.5	2.4	0.8	-1.5	-1.3
Commuting to job workplace: Cycle	2.5	3.1	5.6	-2.4	1.9	-0.2
Myopia	0.3	0.4	0.7	0.7	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	-1.4	-0.5	-1.0
Cholesterol lowering medication	0.6	0.9	1.5	1.2	-0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.0	-0.3	-1.0
Pain experienced in last month	0.8	1.3	2.4	0.8	0.9	1.6
Supplements: Calcium	0.3	0.4	0.7	-0.8	0.6	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	-1.2	0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.6	-0.7	0.3	-1.6
Heart disease (siblings)	0.4	0.5	0.8	0.9	0.4	-0.8
Alcohol drinker status: Previous	1.7	1.9	2.8	1.4	-1.7	-1.0
Pack years of smoking	1.8	2.7	4.9	-2.2	1.0	1.4
Impedance of whole body	1.4	6.9	19.4	1.2	-4.4	-0.1
Leg fat mass (left)	1.5	5.8	10.9	0.9	-3.3	-2.4
Arm predicted mass (left)	0.6	3.0	4.7	-2.2	-0.8	-1.9