TWAS hub - SELL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.164	0.0380	7.8e-10	0.122	0.079	0.090	0.082	0.102	1.1e-14	7.8e-10	4.7e-11	3.0e-10	2.1e-12
2	GTEx	Whole Blood	0.156	0.0440	2.7e-05	0.050	NA	0.077	NA	0.041	2.0e-05	NA	1.4e-07	NA	1.0e-04
3	NTR	Blood	0.325	0.0419	0.0e+00	0.128	0.201	0.233	0.242	0.236	5.2e-39	8.8e-63	5.6e-74	5.9e-77	8.3e-75
4	YFS	Blood	0.547	0.0366	0.0e+00	0.272	0.402	0.439	0.449	0.445	3.1e-89	5.8e-143	1.6e-160	1.1e-165	9.9e-164
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.199	0.0684	9.2e-08	0.084	0.077	0.088	NA	0.086	1.1e-09	5.4e-09	4.2e-10	NA	6.1e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Eye problems/disorders: None of the above	3.2	3.8	7.4	2.7	1.2	1.9	1.7	1.9
Medication for hormone replacement therapy	3.1	3.5	10.0	-1.3	-0.0	-1.6	-1.8	-3.2
Father’s age at death	3.1	4.2	8.4	-0.1	-1.4	-2.7	-2.9	-1.8
Illnesses of siblings: Diabetes	3.1	3.8	5.9	-1.9	-0.3	-2.3	-2.4	-2.1
Mouth/teeth dental problems: Mouth ulcers	3.1	4.9	8.6	2.4	0.7	2.5	1.8	2.9
Crohns Disease (2017)	3.0	6.6	10.8	-1.5	1.9	3.3	3.2	2.5
Blood clot in the leg (DVT)	2.7	3.5	5.9	1.0	-1.4	2.4	2.2	2.0
Breast Cancer	2.6	6.2	12.4	1.0	3.5	2.9	2.7	1.2
Bipolar Disorder (2011)	2.6	2.5	4.5	-0.8	-1.2	-1.9	-2.1	-1.6
Angina (self-reported)	2.6	3.4	4.4	-2.1	-1.7	-1.8	-1.7	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	4.8	1.2	-1.4	2.2	1.9	1.9
Irritable Bowel Disease (IBD)	2.4	5.7	7.6	-2.1	1.4	2.8	2.7	2.7
Blood White Count	2.4	18.1	40.3	1.1	2.0	5.8	6.3	3.3
Blood Eosinophil Count	2.3	17.8	27.1	-3.5	-2.0	-4.4	-5.2	-5.1
Smoking Status	2.3	5.5	10.0	1.0	2.4	2.8	3.2	1.7
HDL Cholesterol	2.2	3.6	5.1	-1.6	-1.7	-2.3	-2.1	-1.8
Lupus	2.2	3.4	9.5	0.7	-3.1	-2.0	-1.6	-0.4
Hearing difficulty/problems with background noise	2.2	3.6	5.5	0.9	2.1	2.2	2.3	1.5
Hair/balding pattern: Pattern 4	2.2	5.4	11.6	-1.3	1.1	-2.5	-2.6	-3.4
Primary Biliary Cirrhosis	2.1	3.1	4.4	-0.2	-1.8	-2.1	-1.8	-2.0
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.9	-0.6	1.7	2.2	1.7	0.5
Emphysema/chronic bronchitis	2.0	2.2	5.6	-2.4	-0.2	-0.9	-1.1	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	4.4	-0.1	-1.2	-1.7	-2.1	-1.8
Angina	1.9	2.5	3.2	-1.8	-1.7	-1.6	-1.4	-1.5
Had major operations	1.9	2.2	5.0	-2.2	0.7	-1.2	-1.3	-1.5
Back pain experienced in last month	1.9	2.8	4.6	2.1	-0.5	1.8	1.4	2.0
Ever had hysterectomy (womb removed)	1.8	2.1	4.9	-0.3	2.2	1.7	1.5	-0.0
Qualifications: CSEs or equivalent	1.8	2.3	5.1	2.3	-0.6	1.4	1.2	1.7
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.6	1.5	-1.3	-1.9	-2.1	-0.2
Time employed in main current job	1.8	2.0	4.6	-0.5	-0.3	-2.1	-1.7	-1.5
Mouth/teeth dental problems: Dentures	1.8	3.0	5.9	-1.8	2.4	1.8	1.4	-0.8
Mouth/teeth dental problems	1.7	2.6	6.4	-0.6	-1.3	-2.5	-1.9	-0.9
Number of full brothers	1.7	2.1	3.3	1.4	0.2	1.8	1.8	1.5
Miserableness	1.7	3.0	6.5	0.8	1.5	1.9	1.5	2.5
Average weekly spirits intake	1.6	2.0	3.7	-1.5	0.9	-1.5	-1.0	-1.9
Ever used hormone-replacement therapy (HRT)	1.6	2.1	7.7	-1.2	0.9	-0.5	-0.2	-2.8
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.8	1.0	0.7	1.9	1.8	0.9
Shortness of breath walking on level ground	1.6	1.9	4.0	-2.0	0.2	-1.3	-1.5	-1.3
Hearing aid user	1.6	1.8	3.0	-1.5	-0.7	-1.7	-1.6	-0.8
Alzheimer’s Disease (in father)	1.5	1.6	4.1	0.2	-1.5	-1.2	-2.0	-0.3
Alzheimer’s Disease (including proxy)	1.5	2.1	4.1	-0.9	-2.0	-1.6	-1.6	-0.9
Diabetes (father)	1.5	1.8	4.2	-0.1	0.3	-1.4	-2.0	-1.7
Had other major operations	1.5	1.8	3.2	-1.1	-1.4	-1.8	-1.4	-0.7
Mood swings	1.5	2.6	5.1	1.7	0.3	1.5	1.7	2.3
Pain experienced in last month	1.5	2.5	3.7	-1.7	-0.0	-1.9	-1.8	-1.6
Medication: Co-codamol	1.4	1.6	3.1	-0.8	-0.4	-1.6	-1.3	-1.8
Alcohol drinker status: Never	1.4	1.6	2.8	-1.7	-1.1	-1.4	-1.3	-0.6
LDL Cholesterol	1.3	2.1	3.9	-0.7	-0.2	-1.4	-2.0	-1.9
Supplements: Zinc	1.3	1.4	2.6	1.6	-0.7	1.3	0.9	1.2
Hand grip strength (right)	1.3	3.5	5.9	-0.0	-2.4	-2.2	-2.4	-0.9
Serious illness, injury or assault to yourself	1.3	1.5	5.5	-2.4	1.2	-0.5	-0.4	-0.6
Hair/balding pattern: Pattern 2	1.3	1.6	5.1	2.3	0.7	0.6	-0.2	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.5	0.9	-0.3	1.6	1.4	1.4
Ever depressed for a whole week	1.3	1.7	3.3	-0.6	-1.8	-1.2	-1.4	-1.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.8	-0.9	1.9	1.4	1.0	0.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.3	2.3	-1.4	-0.2	-0.3	0.7
Medication: Allopurinol	1.2	1.6	2.9	-1.7	0.3	-1.5	-1.0	-1.3
Qualifications: nursing, teaching	1.2	1.8	3.1	-1.1	-0.1	-1.8	-1.6	-1.5
Commuting to job workplace: Walk	1.2	1.3	2.3	-0.9	-0.7	-1.5	-1.4	-1.0
Financial difficulties in last 2 years	1.1	1.5	5.5	2.3	-0.9	0.2	0.2	1.0
Medication: Simvastatin	1.1	1.6	4.5	0.8	2.1	1.3	1.1	0.3
Alcohol intake versus 10 years previously	1.1	1.7	3.6	-0.0	0.2	1.8	1.9	1.2
Number of live births	1.1	1.6	4.9	-0.4	-2.2	-0.9	-1.3	-0.4
Pulse rate	1.1	1.9	3.5	-0.2	-1.3	-1.9	-1.4	-1.4
Noisy workplace	1.1	1.4	3.1	0.0	-0.0	1.4	1.4	1.8
Lung cancer (father)	1.1	1.3	1.8	1.2	1.3	1.2	1.2	0.4
High blood pressure (siblings)	1.1	1.6	3.6	1.9	1.2	1.0	1.5	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.2	0.8	-0.8	1.1	1.5	1.5
Eye problems/disorders: Cataract	1.1	1.3	2.1	-1.5	-0.9	-1.0	-0.9	-1.4
Medication for cholesterol	1.1	1.7	5.0	0.9	0.1	0.9	1.4	2.2
Osteoporosis (self-reported)	1.1	1.3	2.5	1.6	1.2	1.0	1.0	0.7
Irritability	1.1	1.9	3.3	1.0	0.6	1.8	1.7	1.3
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.8	-0.8	0.5	-1.4	-1.5	-2.0
Mother’s age at death	1.0	1.2	2.3	-0.1	1.5	1.5	1.2	-0.3
Number of operations (self-reported)	1.0	1.5	2.3	-1.3	0.1	-1.3	-1.5	-1.4
Alcohol drinker status: Previous	1.0	1.2	1.9	0.3	1.4	1.4	1.3	0.3
Pack years of smoking	1.0	1.5	1.9	-1.3	-1.2	-1.4	-1.1	-1.3
Ulcerative Colitis (UC)	0.9	1.7	3.5	-1.9	0.1	0.9	1.0	1.8
Neuroticism	0.9	2.1	3.5	1.0	1.9	1.6	1.4	1.2
Average weekly fortified wine intake	0.9	1.0	3.1	-0.2	-1.8	-1.1	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	7.0	2.6	0.8	1.4	0.9	0.1
Multivitamins +/- minerals	0.9	1.2	4.3	0.3	-2.1	-1.0	-0.8	0.2
Medication: Atenolol	0.9	1.1	2.4	-1.5	-0.2	-1.0	-0.6	-1.3
Depression (self-reported)	0.9	1.0	2.4	1.5	-0.5	0.1	0.6	1.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.6	1.1	0.4	1.6	1.2	1.4
Number of children fathered	0.9	1.0	4.0	0.6	2.0	0.7	-0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.0	1.7	1.0	1.0	0.5	-0.2
Medication: Blood pressure	0.9	1.6	2.9	-1.0	-1.3	-1.7	-1.1	-1.0
Medication: Seretide 50 evohaler	0.9	1.0	1.9	0.0	-1.4	-1.1	-0.8	-1.2
Diabetes diagnosed by doctor	0.9	1.6	3.0	-0.7	-0.9	-1.7	-1.5	-1.1
Average weekly champagne plus white wine intake	0.9	1.2	2.2	-1.0	-0.9	-1.1	-0.9	-1.5
Hearing difficulty/problems: Yes	0.8	1.2	2.9	-0.1	1.7	1.2	1.3	0.2
Pack years adult smoking proportion	0.8	1.2	1.5	-0.9	-1.2	-1.2	-1.0	-1.0
Townsend deprivation index at recruitment	0.8	1.1	2.4	0.7	0.4	1.6	1.4	0.7
Pain all over the body in last month	0.8	0.9	1.7	-1.3	0.1	-0.7	-0.7	-1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.6	0.7	-2.1	-1.5	-1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.3	-1.5	0.1	0.3	-0.5	-1.5
Migraine (self-reported)	0.8	0.9	3.0	-1.2	1.7	-0.1	-0.3	-0.2
Ever had bowel cancer screening	0.8	0.9	2.1	-1.4	0.2	0.9	1.1	0.6
Breast cancer (self-reported)	0.8	1.0	2.1	-0.4	0.6	-1.4	-0.7	-1.5
Financial situation satisfaction	0.8	0.9	2.1	-0.5	1.1	1.0	1.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.2	1.5	-0.9	0.7	0.6	0.9
Heart disease (siblings)	0.8	1.0	3.0	0.5	1.7	0.8	1.0	0.2
Had menopause	0.7	0.9	2.3	0.6	1.5	0.8	0.9	-0.6
Worrier / anxious feelings	0.7	1.3	2.7	-0.0	1.6	1.3	1.1	0.9
Tense / ‘highly strung’	0.7	1.1	4.1	-0.5	0.7	-0.2	-0.7	-2.0
Medication: Omeprazole	0.7	0.8	2.4	-0.3	0.1	-0.7	-1.0	-1.5
Pulse rate, automated reading	0.7	2.3	5.9	-0.3	-1.1	-1.7	-1.2	-2.4
Basal cell carcinoma (self-reported)	0.7	0.9	3.0	-0.6	-0.2	-0.8	-0.4	-1.7
Ulcerative Colitis	0.6	0.9	3.4	-1.8	0.2	0.4	0.6	0.7
Blood Platelet Count	0.6	6.5	10.2	-2.7	-2.5	-2.3	-2.0	-3.2
Sensitivity / hurt feelings	0.6	1.0	1.9	-0.2	0.6	1.4	1.3	1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-1.6	0.5	0.2	-0.1	-1.0
Nervous feelings	0.6	1.1	2.7	-0.1	0.9	1.6	1.3	-0.3
Diabetes (self-reported)	0.6	0.9	1.7	-0.8	0.2	-1.2	-1.3	-0.8
Illnesses of siblings	0.6	0.8	1.8	-1.0	-1.3	-0.5	-0.8	0.6
Neuroticism score	0.6	1.3	2.5	0.7	0.8	1.6	1.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	-1.3	-0.5	-0.4	-0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	0.7	-1.0	0.8	0.7	1.3
Exposure to tobacco smoke at home	0.6	0.6	1.2	-0.8	0.6	-0.6	-0.7	-1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	-0.9	-0.8	-1.2	-0.8	-0.2
Alcohol intake frequency.	0.6	1.5	2.4	0.8	0.7	1.4	1.5	1.4
Loneliness, isolation	0.6	0.8	1.7	-0.9	0.1	-0.9	-1.3	-0.8
Friendships satisfaction	0.6	0.8	1.4	0.6	0.4	1.2	0.9	1.0
Commuting to job workplace: Public transport	0.6	0.8	2.0	-0.8	1.0	0.4	0.1	-1.4
Supplements: Calcium	0.6	0.7	1.4	1.2	0.1	0.8	0.8	0.9
Bipolar Disorder (2018)	0.5	0.8	1.2	-0.5	-0.6	-1.1	-1.1	-1.0
Prostate Cancer	0.5	0.7	2.2	-1.5	1.2	-0.0	0.3	-0.1
Crohns Disease (2012)	0.5	0.8	1.3	-0.7	0.3	1.1	1.1	1.0
HbA1C	0.5	0.6	1.2	-0.8	0.5	1.1	0.9	-0.1
Neuroticism (2016)	0.5	0.7	2.6	0.5	1.6	0.6	0.4	0.1
Allergy or Eczema	0.5	1.4	2.9	0.7	1.3	-0.8	-1.2	-1.7
Lung FVC	0.5	2.4	3.8	0.2	-1.8	-1.9	-1.9	-1.3
Vitamin and mineral supplements	0.5	0.6	1.5	-1.2	1.1	0.3	0.2	-0.5
Medication: Metformin	0.5	0.7	1.6	-0.7	-0.1	-0.9	-1.3	-0.8
Severe depression (siblings)	0.5	0.5	1.0	-1.0	-0.3	-0.8	-0.9	-0.3
Current tobacco smoking	0.5	0.8	1.7	0.9	-0.1	1.2	1.3	0.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.5	0.5	1.6	-0.9	-1.3	-0.8
Alcohol usually taken with meals	0.5	0.8	1.5	1.2	-0.9	-0.8	-0.4	0.9
Heart attack	0.5	0.6	2.0	-0.1	0.7	-0.7	-0.2	-1.4
Medication: Lansoprazole	0.5	0.6	1.6	-0.7	1.3	-0.2	-0.6	-0.7
Impedance of arm (left)	0.5	2.4	7.0	-0.6	2.6	1.2	1.8	0.2
Length of working week for main job	0.5	0.5	1.1	1.1	-0.4	0.4	0.7	0.8
Birth weight of first child	0.5	1.0	2.6	0.2	-1.6	-1.0	-1.1	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.6	1.3	-0.7	1.0	0.6	0.2
Glaucoma (self-reported)	0.5	0.6	1.8	-1.4	-0.2	0.0	0.4	-1.0
Worry too long after embarrassment	0.5	0.9	2.8	0.5	-0.1	0.7	0.8	1.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.0	-1.0	-0.7	-1.0	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	0.9	1.1	0.4	0.5	0.5
Smoking status: Previous	0.5	0.7	1.5	-0.1	1.2	0.7	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.9	1.4	-1.0	0.0	-0.3	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	-0.8	-0.6	-0.7	-0.9	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.5	-0.1	0.7	1.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	1.0	-0.3	-0.8	-0.8	-1.0
Illnesses of father: None of the above (group 1)	0.5	0.7	2.9	-1.7	-0.1	-0.1	-0.4	-0.5
Fractured/broken bones in last 5 years	0.5	0.7	1.1	0.4	-1.0	-1.0	-0.6	0.8
Commuting to job workplace: Cycle	0.5	0.6	1.0	-0.9	0.6	-0.5	-0.7	-1.0
Cholesterol lowering medication	0.5	0.8	1.9	-0.7	1.1	0.6	0.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	0.5	0.7	-0.4	-0.8	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.0	0.1	1.0	-0.5	-0.2	-1.4
Impedance of whole body	0.5	2.3	7.2	-1.5	2.7	0.7	1.1	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.1	1.8	-1.2	-1.4	-0.7	-0.8	-0.9
Reaction Time	0.4	0.7	2.3	0.0	-0.4	-0.7	-0.8	-1.5
Blood Red Count	0.4	3.6	8.2	2.9	1.0	1.8	1.7	1.6
Impedance of leg (right)	0.4	2.2	4.8	-2.2	1.9	0.0	0.1	-1.5
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	0.8	-0.5	-0.1	-0.4	-1.0
Impedance of leg (left)	0.4	1.9	4.9	-1.8	2.2	0.6	0.7	-0.8
Peak expiratory flow (PEF)	0.4	0.8	3.6	0.5	-0.3	0.3	-0.4	1.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.3	-0.3	-1.0	-0.7	-0.6	1.2
Gout (self-reported)	0.4	0.5	2.0	-1.4	0.2	-0.4	0.0	-0.7
Wheeze or whistling in the chest in last year	0.4	0.8	2.3	-0.2	1.2	0.1	-0.4	-1.5
Medication: Ibuprofen	0.4	0.5	1.2	0.5	-0.8	0.3	0.4	1.1
Comparative height size at age 10	0.4	2.2	4.7	0.2	2.2	1.7	1.6	1.1
Number of full sisters	0.4	0.5	0.9	0.8	0.2	0.6	0.7	0.9
Age at last live birth	0.4	0.5	1.0	1.0	0.5	1.0	0.7	-0.2
Family relationship satisfaction	0.4	0.5	1.1	-0.6	-0.8	0.4	0.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	1.1	-0.6	0.4	0.2	0.9
Average weekly red wine intake	0.4	0.5	1.4	0.8	-0.4	0.6	0.5	1.2
Mineral and other dietary supplements	0.4	0.6	2.2	-1.5	-0.2	-0.5	-0.6	-0.1
Medication: Aspirin	0.4	0.5	1.1	0.9	1.0	0.6	0.7	0.1
Guilty feelings	0.4	0.6	1.2	-0.0	-0.1	1.1	0.8	1.0
Ever taken oral contraceptive pill	0.4	0.4	1.2	-1.1	-0.9	-0.3	0.1	-0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-1.3	-0.6	-0.1	0.2	-0.8
Medication: Blood pressure	0.4	0.7	1.3	-0.3	-0.4	-0.9	-1.1	-1.1
Depression (Nagel 2018)	0.3	0.5	1.3	1.2	0.5	0.6	0.7	0.0
Schizophrenia (2018)	0.3	0.6	1.5	-1.2	-1.2	0.0	-0.2	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.5	0.9	-1.0	-0.4	-0.4	-0.8	-0.6
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.7	-1.0	-0.2	0.3	-0.2
Major Depression (MDD)	0.3	0.3	0.8	0.9	0.5	0.5	-0.3	-0.5
Ovarian Cancer	0.3	0.4	1.3	-1.1	-0.3	-0.5	-0.3	0.2
Mean Putamen Volume	0.3	0.4	1.1	-0.1	-1.0	-0.7	-0.5	-0.3
Fasting Glucose	0.3	0.3	0.6	-0.1	-0.3	0.7	0.7	0.8
Rheumatoid Arthritis	0.3	0.5	0.9	0.1	-0.6	-1.0	-0.9	-0.3
Schizophrenia (2014)	0.3	0.7	1.2	-0.9	-0.8	-0.5	-0.9	-1.1
Waist Hip Ratio (WHR)	0.3	1.4	4.0	-1.0	2.0	0.7	0.4	-1.2
Lung FEV1/FVC ratio	0.3	1.3	3.9	-0.9	0.8	-0.6	-0.9	-2.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.2	0.0	-0.8	-0.7	-1.0
Systolic blood pressure, automated reading	0.3	1.0	2.7	-0.8	-1.6	-0.8	-0.3	-0.9
Relative age voice broke	0.3	0.4	1.1	-0.6	-0.1	1.0	0.7	0.4
Age when periods started (menarche)	0.3	0.7	2.1	1.4	-1.1	0.3	-0.1	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.7	-1.3	-0.6	0.1	-0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.6	1.3	0.2	1.1	0.6	-0.0
Allergy	0.3	0.7	1.8	-0.0	-0.2	0.7	1.0	1.3
Impedance of arm (right)	0.3	1.6	5.4	-0.9	2.3	0.5	1.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.5	0.2	-0.1	1.0	1.2	0.4
Falls in the last year	0.3	0.3	1.1	0.1	1.1	0.6	0.4	-0.3
Comparative body size at age 10	0.3	0.9	1.8	1.3	-0.7	0.5	0.9	1.0
Neck or shoulder pain in last month	0.3	0.4	1.2	1.1	-0.5	0.7	0.3	0.0
Mean time to correctly identify matches	0.3	0.6	2.1	0.6	-0.1	-0.6	-0.6	-1.5
Arm predicted mass (right)	0.3	1.5	2.9	1.3	-1.7	0.4	-0.1	1.6
Suffer from ‘nerves’	0.3	0.5	0.9	1.0	-0.2	-0.7	-0.6	-0.8
Chest pain or discomfort	0.3	0.4	1.3	-1.1	0.2	0.2	0.7	-0.3
Supplements: Vitamin C	0.3	0.3	0.6	0.3	0.7	0.6	0.2	0.7
Leg fat-free mass (right)	0.3	1.7	3.5	1.7	-1.5	0.4	0.2	1.9
Leg predicted mass (right)	0.3	1.8	3.5	1.7	-1.6	0.4	0.2	1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.2	-0.3	-0.9	-0.6	-0.8
Medication: Lisinopril	0.3	0.4	1.4	1.2	0.1	0.7	-0.1	-0.2
Medication: Atorvastatin	0.3	0.4	0.9	-0.9	-0.1	-0.2	-0.2	-1.0
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.4	-0.6	-0.9	-1.0	-0.3
Risk taking	0.3	0.5	2.3	-1.5	-0.1	-0.2	-0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	0.4	-0.4	-0.4	-0.5	-0.9
Diastolic blood pressure, automated reading	0.3	0.9	2.3	-0.2	-1.1	-0.8	-0.6	-1.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	1.1	0.3	0.3	0.4	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.7	0.5	1.3	0.5	0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.4	0.8	0.1	-0.0	-0.1	1.2
Coronary Artery Disease (CAD)	0.2	0.3	0.6	0.4	0.8	-0.5	-0.5	-0.5
Triglycerides	0.2	0.3	0.9	0.4	0.9	0.5	-0.0	0.3
BMI	0.2	0.9	1.9	0.8	-1.4	-0.6	-0.7	-1.1
Systolic Blood Pressure	0.2	1.0	1.8	0.1	-1.4	-1.1	-1.1	-1.0
Hypothyroidism (self reported)	0.2	0.5	1.6	-0.5	-0.8	-0.3	-0.2	-1.3
Hand grip strength (left)	0.2	0.6	1.3	-0.2	-1.1	-0.7	-1.0	0.3
Relative age of first facial hair	0.2	0.5	1.0	-1.0	-0.9	0.6	0.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.1	-0.7	-0.5	-0.6	-0.1
Diabetes (mother)	0.2	0.3	0.5	0.4	-0.7	-0.3	-0.7	-0.3
Leg fat-free mass (left)	0.2	1.2	2.8	1.3	-1.7	-0.0	-0.1	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	0.5	-0.4	-0.6	-0.5	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.9	0.2	-0.8	-0.6	-0.1	-0.9
Body mass index (BMI)	0.2	1.0	2.7	1.3	-1.6	-0.5	-0.5	-0.3
Leg predicted mass (left)	0.2	1.2	2.7	1.4	-1.6	0.1	-0.1	1.3
Past tobacco smoking	0.2	0.3	0.9	0.7	-0.9	-0.2	-0.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.9	0.0	0.6	0.6	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.9	0.5	0.1	-0.2	-0.5
Qualifications: None of the above	0.2	0.3	1.2	0.0	1.1	0.1	0.4	-0.6
Fluid intelligence score	0.2	0.5	1.2	1.1	0.0	0.3	0.5	0.9
Arm fat percentage (right)	0.2	0.6	1.0	0.7	-1.0	-0.7	-0.5	-1.0
Trunk fat-free mass	0.2	0.9	1.8	1.1	-1.2	0.4	-0.2	1.3
Hair/balding pattern: Pattern 3	0.2	0.3	1.3	-1.2	0.4	0.2	0.2	-0.0
Happiness	0.2	0.2	0.5	-0.1	-0.7	0.0	0.6	0.2
Asthma	0.2	0.4	1.1	1.1	0.4	0.6	-0.1	-0.7
Illnesses of mother	0.2	0.3	0.6	0.3	0.7	-0.4	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	3.4	0.6	-0.1	0.5	0.0	1.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.6	-0.4	0.2	0.4	-0.4
Trunk predicted mass	0.2	0.9	1.7	1.1	-1.2	0.4	-0.2	1.3
Breastfed as a baby	0.2	0.3	0.5	0.3	-0.4	0.5	0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.1	0.3	0.9	0.5	-0.3
Pulse wave reflection index	0.2	0.3	0.6	-0.2	0.3	0.7	0.8	0.1
Loud music exposure frequency	0.2	0.2	0.3	0.2	0.5	0.4	0.2	-0.6
Headache pain in last month	0.2	0.3	0.7	-0.3	-0.8	-0.6	-0.4	0.1
Medication: Amlodipine	0.2	0.3	0.7	0.2	-0.2	-0.5	-0.6	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.6	2.3	0.1	-0.5	0.1	-0.5	1.5
Leg fat percentage (right)	0.2	0.6	1.6	0.1	-0.7	-0.6	-0.6	-1.3
Arm fat-free mass (right)	0.2	0.9	2.0	0.9	-1.4	0.3	-0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	1.1	0.1	0.4	0.2	-0.4
Pulse wave peak to peak time	0.2	0.2	0.5	-0.6	0.7	0.0	-0.4	0.5
Health satisfaction	0.2	0.3	0.9	-0.5	-1.0	-0.1	-0.4	-0.3
Qualifications: College or University degree	0.2	0.5	1.2	-0.2	-1.1	-0.1	-0.8	-0.7
Overall health rating	0.2	0.5	1.3	-0.0	1.2	0.4	0.3	-1.0
Leg pain on walking	0.2	0.3	1.1	-0.1	-1.1	0.1	-0.2	0.6
Medication: Aspirin	0.2	0.3	1.0	1.0	0.5	0.3	0.5	0.1
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.1	0.5	-0.6	-0.3	-0.9
Whole body fat-free mass	0.2	1.1	2.0	1.2	-1.4	0.3	-0.2	1.4
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.8	0.5	-0.1	-0.4	-0.8
Asthma (self-reported)	0.2	0.5	1.7	1.3	0.1	0.7	-0.1	-0.5
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.9	-0.5	-0.2	-0.1	-0.5
Smoking status: Current	0.2	0.3	0.8	0.2	-0.0	0.8	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	-0.3	-0.5	-0.6	-1.2	0.3
Whole body water mass	0.2	1.1	2.0	1.2	-1.4	0.2	-0.2	1.3
Wears glasses or contact lenses	0.2	0.2	0.6	0.4	-0.3	0.1	0.8	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.5	0.3	0.2	0.1	0.8
High cholesterol (Self-reported)	0.2	0.3	0.5	0.6	0.5	0.5	0.5	-0.7
Medication: Bendroflumethiazide	0.2	0.3	1.4	1.2	0.2	-0.0	-0.0	-0.1
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.8	0.1	-0.6	-0.3	0.0
Basal metabolic rate	0.2	1.0	1.9	1.3	-1.4	0.3	-0.1	1.2
Age started oral contraceptive pill	0.2	0.3	1.0	-1.0	-0.5	0.2	0.5	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.5	0.3	0.7	-0.3	-0.1	-0.6
Arm predicted mass (left)	0.2	1.1	2.5	1.2	-1.6	0.1	-0.5	1.1
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.3	0.6	0.6	0.6	0.3
Worry (Nagel 2018)	0.1	0.2	0.3	0.5	0.5	0.5	0.4	-0.4
Age at First Birth	0.1	0.1	0.2	0.3	0.3	0.0	-0.1	0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	-0.1	0.5	0.7	0.2	0.0
Height	0.1	2.7	4.7	0.0	0.8	2.2	1.8	2.2
Cardiovascular Disease	0.1	0.2	0.3	-0.1	-0.4	-0.6	-0.4	-0.6
Respiratory disease	0.1	0.3	0.9	0.1	0.5	0.2	-0.4	-0.9
Chronotype (morning person)	0.1	0.3	0.8	0.2	-0.9	-0.5	-0.6	0.1
Tanning	0.1	1.4	2.3	0.6	-1.4	0.8	1.5	1.3
Number of treatments/medications taken	0.1	0.2	0.3	-0.1	0.6	-0.5	-0.5	-0.6
Maternal smoking around birth	0.1	0.2	0.8	-0.3	0.4	-0.1	0.1	-0.9
Fed-up feelings	0.1	0.1	0.2	0.4	-0.5	-0.1	0.2	0.3
Taking other prescription medications	0.1	0.1	0.3	0.5	0.5	-0.0	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.4	0.2	-0.0	0.3
Supplements: Glucosamine	0.1	0.1	0.6	0.8	-0.2	0.1	-0.2	0.2
Sitting height	0.1	0.4	0.7	-0.8	0.4	-0.4	-0.8	0.5
High blood pressure (mother)	0.1	0.1	0.3	0.5	-0.5	-0.1	0.2	0.1
Number of incorrect matches in round	0.1	0.2	0.9	-0.5	0.1	-0.1	-0.0	-1.0
Forced vital capacity (FVC)	0.1	0.5	1.2	0.3	-0.4	-0.5	-0.9	1.1
Weight	0.1	0.5	1.2	1.1	-0.9	0.3	0.1	0.5
Hip circumference	0.1	0.3	1.0	1.0	-0.6	0.2	0.0	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	0.3	-0.2	-0.4	-0.8	1.1
Prospective memory result	0.1	0.1	0.3	-0.3	-0.1	0.3	0.6	0.0
Arm fat mass (right)	0.1	0.5	1.2	1.0	-1.1	-0.3	-0.3	-0.4
Standing height	0.1	1.2	2.2	-0.3	1.1	1.3	1.0	1.5
Medication: Paracetamol	0.1	0.1	0.3	0.4	0.0	-0.5	-0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	-0.3	-0.9	-0.2	0.4	-0.6
Birth weight	0.1	0.3	0.8	-0.0	0.8	-0.1	0.2	0.9
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.2	-0.4	-0.6	-0.3	0.0
Age at first live birth	0.1	0.2	0.4	0.5	-0.6	0.6	0.5	0.2
Heart disease (mother)	0.1	0.2	0.4	0.4	0.5	0.0	-0.2	-0.7
Whole body fat mass	0.1	0.3	0.9	0.8	-1.0	-0.0	0.0	-0.3
Leg fat mass (right)	0.1	0.4	1.1	1.0	-1.0	-0.1	-0.1	-0.1
Knee pain experienced in last month	0.1	0.1	0.3	-0.2	-0.3	-0.2	-0.4	-0.5
Arm fat percentage (left)	0.1	0.4	1.1	1.1	-0.8	-0.1	0.0	-0.3
Medication: Gliclazide	0.1	0.1	0.2	-0.4	-0.1	0.3	0.4	0.4
Arm fat mass (left)	0.1	0.5	1.6	1.3	-1.0	-0.2	-0.2	-0.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.2	-0.6	-0.3	-0.2	-0.2
Medication: Paracetamol	0.1	0.2	0.6	0.3	-0.2	-0.8	-0.5	-0.1
Ever smoked	0.1	0.2	0.5	-0.7	0.3	-0.3	-0.2	-0.5
Leg fat percentage (left)	0.1	0.3	0.8	0.3	-0.7	-0.2	-0.3	-0.9
Arm fat-free mass (left)	0.1	0.7	1.4	1.0	-1.2	0.1	-0.5	0.9
Myopia	0.1	0.1	0.3	0.1	-0.1	0.5	0.2	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.6	0.1	0.4	-0.1	0.5
Leg fat mass (left)	0.1	0.4	1.2	1.1	-0.9	0.2	0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.1	0.1	0.3	0.3	0.2
Heel T-Score	0.0	0.2	0.7	0.2	-0.8	0.0	-0.4	-0.1
Hair Pigment	0.0	1.2	3.4	0.9	-1.9	0.3	0.8	1.0
Trunk fat percentage	0.0	0.2	0.8	0.1	-0.3	-0.1	0.1	-0.9
High blood pressure	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.2	-0.1
Trunk fat mass	0.0	0.2	0.4	0.3	-0.7	-0.0	0.0	-0.6
Waist circumference	0.0	0.1	0.2	0.4	-0.2	0.2	-0.0	-0.3
Medication: Ramipril	0.0	0.1	0.3	0.1	0.1	-0.5	-0.1	-0.1
Medication: Cholesterol lowering	0.0	0.1	0.3	0.1	0.6	0.0	0.1	-0.1
Body fat percentage	0.0	0.2	0.8	0.3	-0.3	-0.1	-0.0	-0.9
Hypertension (Self-reported)	0.0	0.1	0.2	-0.3	-0.3	-0.4	-0.0	-0.2

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