Hub : Genes

SELPLG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.3914	0.0362	0.0e+00	0.247	0.275	0.291	0.286	0.291	6.1e-80	2.2e-90	1.1e-96	1.6e-94	2.0e-96
2	TCGA	Breast Invasive Carcinoma	0.0393	0.0163	7.9e-05	-0.001	0.010	0.008	NA	0.001	5.1e-01	3.4e-03	7.4e-03	NA	1.7e-01
3	TCGA	Stomach Adenocarcinoma	0.0810	0.0330	8.1e-04	0.008	0.028	0.005	NA	0.011	8.5e-02	3.6e-03	1.4e-01	NA	4.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.7	0.8	0.3	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.3	-0.0	-0.8
Depressed Affect (Nagel 2018)	1.0	2.1	4.0	-0.5	1.4	2.0
Depression (Nagel 2018)	0.2	0.3	0.5	0.5	-0.4	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	0.3	-1.5	-0.7
Neuroticism (Nagel 2018)	0.5	1.2	2.4	-0.2	1.1	1.5
Schizophrenia (2018)	0.0	0.1	0.2	-0.3	-0.3	-0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	2.4	-1.0	-1.5	0.5
Worry (Nagel 2018)	0.1	0.1	0.2	0.5	-0.0	0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.1	-0.3	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.3	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.5	0.3	0.3
Crohns Disease (2017)	1.5	3.3	6.2	-0.7	2.5	1.8
Irritable Bowel Disease (IBD)	0.8	2.0	2.8	-0.7	1.6	1.7
Ulcerative Colitis (UC)	0.4	0.7	1.0	-0.8	0.6	1.0
Major Depression (MDD)	0.1	0.1	0.1	-0.4	-0.3	0.1
Reaction Time	0.1	0.2	0.4	-0.3	-0.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.0	1.4	-0.5	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	1.1	-0.5	1.1	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	0.9	-0.6	-0.2	0.9
Bipolar Disorder (2011)	1.6	1.6	4.7	2.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.1	0.2	1.1	1.0
Coronary Artery Disease (CAD)	7.0	8.3	11.5	2.0	-3.4	-3.1
Crohns Disease (2012)	0.2	0.4	0.7	0.2	0.8	0.7
Mean Putamen Volume	0.6	0.7	1.4	-1.2	-0.6	-0.5
Fasting Glucose	1.0	1.2	2.1	0.3	-1.4	-1.1
HbA1C	0.6	0.7	1.7	-1.3	0.3	-0.5
HDL Cholesterol	1.6	2.6	4.4	1.1	-1.5	-2.1
LDL Cholesterol	0.5	0.8	1.5	-0.1	-1.2	-1.0
Lupus	0.5	0.8	1.3	1.2	-0.4	-1.0
Neuroticism (2016)	3.0	4.3	6.2	-1.3	2.5	2.3
Primary Biliary Cirrhosis	3.0	4.3	6.3	-1.8	1.8	2.5
Rheumatoid Arthritis	0.2	0.2	0.3	0.6	0.2	0.5
Schizophrenia (2014)	0.1	0.2	0.4	-0.3	-0.6	-0.4
Triglycerides	0.1	0.2	0.6	-0.8	-0.1	0.1
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.8	-2.2	1.3	0.8
Ulcerative Colitis	0.2	0.3	0.5	-0.3	-0.6	0.7
Blood Eosinophil Count	0.2	1.5	3.5	0.9	0.3	1.9
Blood Platelet Count	3.6	41.4	56.1	-4.9	6.7	7.5
Blood Red Count	0.2	2.3	3.0	1.5	-1.2	-1.7
Blood White Count	0.1	0.6	1.1	1.1	-0.9	-0.2
Heel T-Score	0.3	2.3	5.8	-0.8	-0.7	-2.4
BMI	0.1	0.4	0.8	-0.2	0.9	0.6
Height	0.1	2.7	6.4	2.5	0.1	-1.2
Waist Hip Ratio (WHR)	0.0	0.2	0.3	0.6	-0.4	0.1
Systolic Blood Pressure	0.1	0.3	0.6	0.6	0.2	-0.8
Smoking Status	0.5	1.3	2.2	1.0	1.5	-0.8
Allergy or Eczema	0.2	0.5	1.4	0.2	-0.4	1.2
Cardiovascular Disease	1.9	6.2	11.7	1.9	-3.4	-1.8
Hypothyroidism (self reported)	1.6	3.6	6.7	1.6	-2.6	-1.2
Respiratory disease	0.9	2.0	3.9	1.0	-1.0	-2.0
Type 2 Diabetes (T2D) (2018)	1.8	3.3	7.0	1.4	-2.6	-1.1
Lung FEV1/FVC ratio	1.2	5.9	13.7	-1.7	1.1	3.7
Lung FVC	0.8	4.2	8.8	-1.9	3.0	0.7
Neuroticism	0.3	0.7	1.5	-0.4	0.8	1.2
Chronotype (morning person)	1.5	3.4	3.8	-1.8	2.0	1.8
Hair Pigment	0.1	3.8	4.4	-1.7	2.1	2.0
Tanning	0.1	1.1	2.2	0.9	0.6	-1.5
Hand grip strength (left)	0.3	0.9	1.9	0.6	-1.4	-0.6
Number of treatments/medications taken	1.0	1.8	3.0	1.7	-1.5	-0.3
Average weekly spirits intake	0.4	0.5	0.9	-0.9	0.8	0.2
Sensitivity / hurt feelings	0.8	1.4	2.8	-0.6	1.7	1.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.7	-0.0	0.1	1.7
Hearing difficulty/problems: Yes	2.2	3.3	5.7	0.6	-2.0	-2.4
Relative age of first facial hair	0.2	0.4	0.9	-0.4	-0.9	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	-0.1	-1.4	-0.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.8	0.8	-0.9	-0.9
Ever had hysterectomy (womb removed)	4.2	4.7	6.1	1.9	-2.5	-2.1
Systolic blood pressure, automated reading	0.1	0.4	0.9	-0.4	0.9	-0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.2	-0.7	1.0	1.1
Angina	0.4	0.6	1.6	-0.2	-1.3	-0.2
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.4	0.1	0.2
Vitamin and mineral supplements	1.1	1.5	2.3	-1.5	1.4	-0.4
Supplements: Zinc	0.4	0.4	0.6	0.6	-0.8	-0.5
Medication: Co-codamol	0.7	0.8	1.8	-0.3	1.3	0.6
Medication: Metformin	0.1	0.1	0.1	-0.4	0.3	0.2
Diabetes (father)	0.0	0.1	0.1	-0.2	0.0	-0.4
Diabetes (mother)	6.5	8.3	9.9	3.1	-2.6	-2.8
Severe depression (siblings)	1.3	1.4	2.6	0.4	-1.2	-1.6
Pack years adult smoking proportion	0.4	0.6	1.7	-0.0	-0.1	-1.3
Impedance of leg (right)	0.2	1.0	1.9	-1.4	-1.0	0.5
Leg fat-free mass (left)	0.3	1.8	3.8	2.0	1.2	-0.2
Trunk fat percentage	0.1	0.5	1.0	0.2	1.0	0.5
Hand grip strength (right)	0.3	0.7	1.1	0.9	-1.0	-0.6
Townsend deprivation index at recruitment	1.3	1.8	2.9	-0.7	-1.7	-1.4
Current tobacco smoking	0.5	0.8	1.6	0.5	0.6	-1.3
Average weekly fortified wine intake	0.3	0.3	0.6	0.4	-0.4	-0.8
Maternal smoking around birth	0.7	1.1	1.6	0.3	1.3	1.2
Fed-up feelings	0.7	1.2	3.1	-0.2	0.7	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.3	-0.5	-0.0
Relative age voice broke	0.3	0.4	1.0	0.3	-1.0	-0.4
Taking other prescription medications	0.6	0.9	1.8	0.1	-1.3	1.0
Age when periods started (menarche)	0.5	1.2	2.3	-0.7	1.5	0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	0.7	-1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.1	-0.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.3	0.0	-0.8
Qualifications: CSEs or equivalent	1.5	2.0	3.2	-0.9	1.8	1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.7	-0.0	-0.4
High blood pressure	0.7	1.9	3.6	1.2	-1.9	-0.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.2	-1.2	0.8	1.8
Multivitamins +/- minerals	1.2	1.5	3.0	1.7	-1.2	-0.5
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.7	0.4	-0.3
Supplements: Glucosamine	0.5	0.7	1.0	1.0	0.0	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	0.4	-0.9	-0.9
Medication: Atenolol	0.0	0.1	0.2	0.1	0.0	0.4
Medication: Levothyroxine sodium	1.3	2.2	4.4	0.9	-2.1	-1.2
Sitting height	0.5	3.3	5.0	2.2	-1.0	-2.0
Chronic bronchitis/emphysema (father)	1.3	1.5	2.5	0.5	-1.3	-1.6
High blood pressure (mother)	3.2	4.4	9.4	3.1	-1.3	-1.5
Body mass index (BMI)	0.1	0.4	1.0	1.0	0.5	-0.0
Impedance of leg (left)	0.2	0.9	2.2	-1.5	-0.3	0.7
Leg predicted mass (left)	0.3	1.7	3.8	2.0	1.1	-0.2
Trunk fat mass	0.1	0.5	1.2	1.1	0.7	0.1
Waist circumference	0.2	0.7	1.9	1.4	0.2	-0.2
Number of incorrect matches in round	0.5	0.8	1.4	0.3	-1.2	-0.9
Past tobacco smoking	0.4	0.8	1.9	-0.4	-1.4	-0.6
Alcohol usually taken with meals	0.3	0.4	1.1	1.0	-0.2	0.4
Nervous feelings	0.0	0.1	0.1	0.4	-0.4	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.1	-0.2	-0.1
Hearing difficulty/problems with background noise	0.7	1.1	2.7	0.0	-1.6	-0.7
Hair/balding pattern: Pattern 2	1.2	1.5	4.3	-2.1	-0.2	0.3
Had menopause	0.0	0.0	0.1	-0.3	-0.1	0.2
Had other major operations	0.3	0.3	0.6	-0.8	-0.4	-0.5
Forced vital capacity (FVC)	0.5	1.9	5.3	-0.4	2.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.6	0.1	-0.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.9	1.4	-0.8	-0.3
Qualifications: None of the above	0.1	0.2	0.4	-0.5	-0.6	0.0
Financial difficulties in last 2 years	0.3	0.4	0.6	-0.6	0.5	0.8
Mouth/teeth dental problems	0.2	0.3	0.8	-0.9	0.2	0.1
Heart attack	2.6	3.3	6.3	0.6	-2.5	-1.8
Allergy	0.1	0.2	0.3	-0.0	-0.4	-0.6
Pain all over the body in last month	1.1	1.2	1.8	-1.0	0.9	1.3
Diabetes (self-reported)	0.3	0.5	1.3	0.3	-1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.5	-0.7	0.6	0.7
Medication: Ramipril	1.4	1.8	4.4	0.3	-2.1	-0.9
Medication: Simvastatin	1.5	2.1	6.0	-0.3	-2.5	-0.6
Fluid intelligence score	0.2	0.3	0.5	0.7	0.6	0.5
Illnesses of siblings	2.0	2.8	4.5	-2.1	1.6	1.1
Neuroticism score	0.9	1.8	3.7	-0.9	0.9	1.9
Weight	0.3	1.4	3.5	1.9	0.7	-0.3
Impedance of arm (right)	0.3	1.5	2.6	-1.6	0.6	1.3
Arm fat percentage (right)	0.1	0.4	0.5	0.7	0.5	0.6
Trunk fat-free mass	0.7	4.1	9.8	3.1	-0.7	-1.4
Hip circumference	0.1	0.5	0.9	1.0	0.7	0.3
Time employed in main current job	3.1	3.5	5.8	-2.4	1.4	1.7
Alcohol intake versus 10 years previously	0.9	1.3	1.9	0.4	-1.4	-1.4
Father’s age at death	0.6	0.8	2.2	-1.5	-0.0	-0.6
Worrier / anxious feelings	0.1	0.1	0.4	-0.6	-0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	0.4	-1.0	-0.6
Falls in the last year	2.4	3.2	5.2	1.9	-1.0	-2.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.3	-0.5	-0.6
Number of live births	0.4	0.6	1.8	1.3	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	6.4	-0.7	2.5	1.8
Pulse rate	1.7	2.9	4.2	-1.3	2.0	1.7
Happiness	0.5	0.6	1.1	1.1	-0.5	-0.5
Noisy workplace	1.0	1.3	2.0	0.5	-1.3	-1.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.0	-0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.0	-1.4	-1.2	-0.4
Mouth/teeth dental problems: Dentures	1.8	3.1	3.9	-1.3	2.0	1.9
Asthma	0.1	0.2	0.4	-0.2	0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.3	0.2	-0.1
Medication: Cholesterol lowering	0.7	1.1	3.1	-0.0	-1.8	-0.5
Depression (self-reported)	1.2	1.5	2.7	1.3	-1.6	-0.4
Medication: Lansoprazole	1.1	1.2	3.1	0.4	-1.8	-0.7
Prospective memory result	2.6	3.2	5.1	1.1	-2.2	-1.8
Lung cancer (father)	0.0	0.0	0.1	0.3	0.1	-0.1
Illnesses of mother	1.6	1.9	3.4	-1.8	0.9	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	4.9	-1.3	2.2	1.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.8	-0.1	0.1
Impedance of arm (left)	0.6	3.0	4.5	-2.1	1.5	1.4
Arm fat mass (right)	0.2	0.7	2.0	1.4	0.5	-0.0
Trunk predicted mass	0.7	4.1	10.1	3.2	-0.7	-1.3
Standing height	0.2	1.5	4.0	2.0	0.6	-0.6
Length of working week for main job	0.7	0.8	1.9	0.5	-1.4	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.7	0.4	-0.3
Breastfed as a baby	0.6	0.8	0.9	1.0	-0.9	-0.8
Tense / ‘highly strung’	1.3	2.1	3.2	1.8	-1.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	3.4	1.9	-1.3	-1.2
Hair/balding pattern: Pattern 4	0.8	1.9	4.0	1.2	-2.0	-0.5
Birth weight of first child	2.7	4.9	6.5	2.5	-2.1	-2.0
Peak expiratory flow (PEF)	1.6	3.6	7.7	-0.7	1.6	2.8
Pulse wave reflection index	0.9	1.1	2.5	0.4	-1.6	-0.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.0	0.6	-1.1	-1.4
Loud music exposure frequency	0.1	0.1	0.4	-0.1	-0.6	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.4	0.0	0.2
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.1	1.4	-1.8	-1.0
Blood clot in the leg (DVT)	0.4	0.5	1.0	1.0	0.4	0.5
Medication: Paracetamol	0.5	0.9	2.2	1.5	0.4	0.6
Headache pain in last month	1.9	3.2	3.9	2.0	-1.8	-1.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.6	-1.1	2.2	0.6
Glaucoma (self-reported)	0.1	0.1	0.2	-0.4	-0.2	0.4
Gout (self-reported)	3.2	4.4	6.1	2.5	-2.3	-1.4
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	4.7	1.4	-2.2	-1.2
Medication: Amlodipine	0.6	0.8	1.9	0.4	-1.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	-0.0	1.5	0.6
Birth weight	0.1	0.2	0.4	0.7	0.2	0.5
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.0	2.0	-1.5	-1.2
High blood pressure (siblings)	6.8	9.8	12.6	3.5	-3.2	-2.5
Forced vital capacity (FVC), Best measure	0.4	1.4	3.2	-0.9	1.8	0.5
Body fat percentage	0.1	0.3	0.4	0.5	0.6	0.4
Leg fat percentage (right)	0.0	0.1	0.2	0.4	-0.3	0.4
Arm fat-free mass (right)	0.3	1.8	4.5	2.1	0.4	-0.8
Exposure to tobacco smoke outside home	0.1	0.2	0.4	-0.1	0.2	-0.6
Comparative body size at age 10	0.6	1.7	3.0	-0.8	1.7	1.3
Number of full brothers	0.5	0.6	1.0	-1.0	0.8	-0.4
Worry too long after embarrassment	0.5	0.8	1.1	-1.1	0.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	4.5	2.0	-1.7	-2.1
Wheeze or whistling in the chest in last year	4.2	7.4	10.9	2.0	-3.3	-2.7
Number of children fathered	0.3	0.4	0.7	0.4	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	6.2	2.5	-1.8	-2.0
Age at first live birth	0.3	0.5	1.1	-1.1	0.5	-0.2
Pulse wave peak to peak time	0.4	0.4	1.3	1.1	0.1	-0.1
Health satisfaction	1.3	1.7	2.2	1.1	-1.5	-1.3
Shortness of breath walking on level ground	1.7	2.0	2.6	1.0	-1.6	-1.5
Qualifications: College or University degree	0.0	0.0	0.1	-0.0	0.1	0.3
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.2	-0.3	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.1	0.2	-0.7	-1.0
Emphysema/chronic bronchitis	2.0	2.2	3.0	1.3	-1.4	-1.7
Medication for pain relief, constipation, heartburn	0.6	1.1	2.2	-1.5	1.0	0.1
Neck or shoulder pain in last month	0.1	0.2	0.2	-0.4	0.4	0.4
Medication: Blood pressure	1.0	1.8	3.8	1.1	-2.0	-0.4
Angina (self-reported)	0.6	0.7	1.9	0.2	-1.4	-0.4
Migraine (self-reported)	6.6	8.2	10.9	2.5	-3.3	-2.7
Medication: Ibuprofen	0.2	0.2	0.5	0.3	0.7	0.2
Medication: Allopurinol	2.0	2.7	4.1	2.0	-1.8	-0.9
Medication: Omeprazole	0.1	0.1	0.3	0.3	-0.5	-0.2
Medication: Seretide 50 evohaler	0.7	0.8	1.3	0.7	-0.8	-1.2
Mean time to correctly identify matches	0.2	0.4	1.0	0.2	-0.3	-1.0
Heart disease (mother)	0.4	0.5	1.2	-0.3	-0.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	0.7	1.3	-0.3
Whole body fat mass	0.2	0.7	1.7	1.3	0.6	0.0
Leg fat mass (right)	0.1	0.6	1.7	1.3	0.0	-0.1
Arm predicted mass (right)	0.4	2.3	6.0	2.5	0.3	-0.9
Pulse rate, automated reading	2.9	9.3	14.5	-2.3	3.8	2.8
Alcohol intake frequency.	1.2	2.7	5.7	2.4	-1.0	-1.2
Comparative height size at age 10	0.2	0.9	2.0	1.4	-0.8	-0.5
Number of full sisters	0.7	0.9	1.7	0.1	1.3	1.0
Suffer from ‘nerves’	0.9	1.4	1.6	-1.2	1.3	1.1
Overall health rating	0.5	1.0	3.0	-0.1	-1.7	-0.4
Chest pain or discomfort	1.9	2.8	4.3	1.1	-1.7	-2.1
Had major operations	2.7	3.1	3.2	-1.8	1.8	1.8
Age at last live birth	0.1	0.1	0.2	0.0	-0.4	-0.4
Family relationship satisfaction	0.6	0.8	1.9	1.4	-0.6	-0.0
Leg pain on walking	0.4	0.5	1.1	-0.1	1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	1.9	-0.9	1.2	1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	-0.6	0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.9	0.6	0.6	1.4
Medication: Aspirin	1.5	2.0	4.9	0.4	-2.2	-1.0
Supplements: Vitamin C	0.4	0.4	1.0	1.0	-0.5	-0.1
Knee pain experienced in last month	1.2	1.9	4.0	1.3	-2.0	-0.3
Hypertension (Self-reported)	0.8	2.3	4.5	1.4	-2.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	1.0	-0.4	-0.6
Illnesses of father: Heart disease	2.1	3.0	3.3	1.7	-1.8	-1.7
Illnesses of siblings: Diabetes	0.8	0.9	1.3	-1.1	0.6	1.1
Smoking status: Previous	0.3	0.5	1.1	0.1	1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	0.1	0.5	0.3
Whole body fat-free mass	0.5	2.6	6.9	2.6	0.3	-0.9
Leg fat-free mass (right)	0.4	1.9	3.6	1.9	1.5	-0.2
Arm fat percentage (left)	0.1	0.5	0.9	0.5	0.9	0.7
Average weekly red wine intake	0.7	1.1	1.5	-0.9	0.9	1.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.3	-0.4	1.0	1.5
Mood swings	0.5	0.8	2.0	0.0	0.7	1.4
Loneliness, isolation	0.8	1.2	3.1	-0.4	0.4	1.8
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.3	0.6	0.6
Ever had bowel cancer screening	1.4	1.6	2.5	0.8	-1.6	-1.4
Diabetes diagnosed by doctor	0.4	0.6	1.5	0.2	-1.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	0.9	-0.1	-0.3
Friendships satisfaction	1.1	1.3	3.7	1.9	-0.6	-0.1
Qualifications: nursing, teaching	0.4	0.6	1.4	-0.2	1.2	0.6
Commuting to job workplace: Walk	0.8	0.9	1.5	0.4	-1.2	-1.0
Eye problems/disorders: Cataract	0.1	0.2	0.4	0.0	0.7	0.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.3	1.1	-1.0	-1.2
Medication for cholesterol	0.4	0.6	1.8	-0.2	1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	3.0	4.7	0.9	-2.2	-1.8
Back pain experienced in last month	0.9	1.3	1.8	1.3	-1.1	-1.0
Mineral and other dietary supplements	4.0	5.4	11.4	-1.8	3.4	1.2
Breast cancer (self-reported)	0.0	0.0	0.0	-0.2	-0.1	0.1
Asthma (self-reported)	0.1	0.2	0.3	-0.4	0.6	-0.4
Osteoporosis (self-reported)	1.6	2.0	4.0	1.2	-2.0	-0.8
Osteoarthritis (self-reported)	0.4	0.5	0.7	0.8	-0.6	-0.6
Medication: Aspirin	1.2	1.6	4.0	0.2	-2.0	-0.9
Medication: Gliclazide	0.0	0.0	0.1	-0.4	-0.1	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	-0.4	0.7	0.8
Smoking status: Current	0.5	0.8	1.7	0.6	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	-0.0	0.9	0.4
Whole body water mass	0.5	2.6	7.0	2.6	0.2	-0.9
Leg predicted mass (right)	0.4	2.0	3.5	1.9	1.5	-0.1
Arm fat mass (left)	0.2	0.7	1.8	1.4	0.6	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	0.5	-1.3	0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.3	0.4	0.7
Miserableness	0.1	0.2	0.4	-0.3	0.6	0.3
Guilty feelings	1.9	2.9	6.3	-0.2	1.5	2.5
Wears glasses or contact lenses	0.8	0.9	2.0	-1.4	-0.8	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.5	0.6	0.1
Hearing aid user	2.0	2.3	4.2	-2.0	1.6	0.3
Mother’s age at death	1.1	1.3	2.2	-1.5	0.0	1.3
Financial situation satisfaction	1.2	1.4	2.0	1.4	-1.1	-1.0
Tinnitus: Yes, now most or all of the time	2.0	2.3	3.5	-0.7	1.7	1.9
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.3	0.0	0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	0.1	0.4
Medication: Blood pressure	0.5	1.0	1.4	1.1	-1.2	-0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.3	1.5	-1.4	-0.3
Supplements: Fish oil (including cod liver oil)	2.5	3.3	6.7	1.3	-2.6	-1.2
High cholesterol (Self-reported)	0.4	0.7	2.0	-0.0	-1.4	0.3
Medication: Bendroflumethiazide	0.4	0.6	0.8	0.6	-0.9	-0.9
Medication: Paracetamol	0.4	0.7	1.7	1.3	0.3	0.5
Medication: Lisinopril	0.8	1.0	1.8	-0.7	1.3	1.0
Medication: Atorvastatin	0.6	0.8	1.0	0.8	-1.0	-0.8
Illnesses of father: High blood pressure	1.3	1.6	3.3	1.8	-0.9	-0.9
Alcohol drinker status: Never	0.6	0.7	2.1	1.4	-0.0	-0.4
Ever smoked	0.4	0.8	1.6	0.2	1.3	0.8
Basal metabolic rate	0.4	2.2	6.1	2.5	0.4	-0.7
Leg fat percentage (left)	0.0	0.2	0.3	0.4	0.2	0.5
Arm fat-free mass (left)	0.5	2.3	6.0	2.4	0.0	-1.0
Number of operations (self-reported)	0.7	1.1	2.4	-1.5	0.8	0.5
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.6	0.3	-0.3
Irritability	1.7	2.8	4.2	-2.0	1.3	1.6
Risk taking	0.3	0.4	0.7	0.8	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.7	-0.5	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-0.0	-0.8	-1.4
Age started oral contraceptive pill	0.5	0.6	1.4	0.6	-0.4	-1.2
Diastolic blood pressure, automated reading	0.1	0.2	0.6	0.1	0.8	0.3
Ever depressed for a whole week	0.7	0.9	2.5	1.6	0.3	-0.3
Unable to work because of sickness or disability	0.7	0.9	2.0	0.5	-0.7	-1.4
Commuting to job workplace: Cycle	2.5	3.0	3.2	-1.7	1.7	1.8
Myopia	0.2	0.4	1.0	0.1	-0.2	-1.0
Vascular/heart problems diagnosed by doctor	1.2	3.2	6.7	-1.4	2.6	1.1
Cholesterol lowering medication	1.1	1.6	4.8	0.0	-2.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	-0.6	-0.0
Pain experienced in last month	0.4	0.7	1.2	-0.4	1.1	-0.9
Supplements: Calcium	2.0	2.2	4.3	1.5	-2.1	0.3
Basal cell carcinoma (self-reported)	1.1	1.4	2.0	-0.8	1.4	1.2
Heart attack/myocardial infarction (self-reported)	2.4	3.1	5.6	0.5	-2.4	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.8	0.6	0.5
Heart disease (siblings)	0.3	0.3	0.7	0.5	-0.8	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.1	0.3	-0.3	0.1
Pack years of smoking	0.4	0.6	1.6	-0.3	-0.2	-1.3
Impedance of whole body	0.4	2.1	4.1	-2.0	0.8	1.3
Leg fat mass (left)	0.1	0.6	1.6	1.3	0.3	-0.1
Arm predicted mass (left)	0.5	2.5	6.4	2.5	-0.2	-1.1