Hub : Genes

SELPLG

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.3914 0.0362 0.0e+00 0.247 0.275 0.291 0.286 0.291 6.1e-80 2.2e-90 1.1e-96 1.6e-94 2.0e-96
2 TCGA Breast Invasive Carcinoma 0.0393 0.0163 7.9e-05 -0.001 0.010 0.008 NA 0.001 5.1e-01 3.4e-03 7.4e-03 NA 1.7e-01
3 TCGA Stomach Adenocarcinoma 0.0810 0.0330 8.1e-04 0.008 0.028 0.005 NA 0.011 8.5e-02 3.6e-03 1.4e-01 NA 4.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 0.7 0.8 0.3 -0.6
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.3 -0.0 -0.8
Depressed Affect (Nagel 2018) 1.0 2.1 4.0 -0.5 1.4 2.0
Depression (Nagel 2018) 0.2 0.3 0.5 0.5 -0.4 0.7
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.2 0.3 -1.5 -0.7
Neuroticism (Nagel 2018) 0.5 1.2 2.4 -0.2 1.1 1.5
Schizophrenia (2018) 0.0 0.1 0.2 -0.3 -0.3 -0.4
Schizophrenia vs Biploar Disorder 0.9 1.2 2.4 -1.0 -1.5 0.5
Worry (Nagel 2018) 0.1 0.1 0.2 0.5 -0.0 0.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.1 -0.3 0.5
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.3 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.5 0.3 0.3
Crohns Disease (2017) 1.5 3.3 6.2 -0.7 2.5 1.8
Irritable Bowel Disease (IBD) 0.8 2.0 2.8 -0.7 1.6 1.7
Ulcerative Colitis (UC) 0.4 0.7 1.0 -0.8 0.6 1.0
Major Depression (MDD) 0.1 0.1 0.1 -0.4 -0.3 0.1
Reaction Time 0.1 0.2 0.4 -0.3 -0.1 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.0 1.4 -0.5 -0.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.4 0.5 1.1 -0.5 1.1 0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 0.9 -0.6 -0.2 0.9
Bipolar Disorder (2011) 1.6 1.6 4.7 2.2 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.1 0.2 1.1 1.0
Coronary Artery Disease (CAD) 7.0 8.3 11.5 2.0 -3.4 -3.1
Crohns Disease (2012) 0.2 0.4 0.7 0.2 0.8 0.7
Mean Putamen Volume 0.6 0.7 1.4 -1.2 -0.6 -0.5
Fasting Glucose 1.0 1.2 2.1 0.3 -1.4 -1.1
HbA1C 0.6 0.7 1.7 -1.3 0.3 -0.5
HDL Cholesterol 1.6 2.6 4.4 1.1 -1.5 -2.1
LDL Cholesterol 0.5 0.8 1.5 -0.1 -1.2 -1.0
Lupus 0.5 0.8 1.3 1.2 -0.4 -1.0
Neuroticism (2016) 3.0 4.3 6.2 -1.3 2.5 2.3
Primary Biliary Cirrhosis 3.0 4.3 6.3 -1.8 1.8 2.5
Rheumatoid Arthritis 0.2 0.2 0.3 0.6 0.2 0.5
Schizophrenia (2014) 0.1 0.2 0.4 -0.3 -0.6 -0.4
Triglycerides 0.1 0.2 0.6 -0.8 -0.1 0.1
Type 2 Diabetes (T2D) (2012) 2.1 2.4 4.8 -2.2 1.3 0.8
Ulcerative Colitis 0.2 0.3 0.5 -0.3 -0.6 0.7
Blood Eosinophil Count 0.2 1.5 3.5 0.9 0.3 1.9
Blood Platelet Count 3.6 41.4 56.1 -4.9 6.7 7.5
Blood Red Count 0.2 2.3 3.0 1.5 -1.2 -1.7
Blood White Count 0.1 0.6 1.1 1.1 -0.9 -0.2
Heel T-Score 0.3 2.3 5.8 -0.8 -0.7 -2.4
BMI 0.1 0.4 0.8 -0.2 0.9 0.6
Height 0.1 2.7 6.4 2.5 0.1 -1.2
Waist Hip Ratio (WHR) 0.0 0.2 0.3 0.6 -0.4 0.1
Systolic Blood Pressure 0.1 0.3 0.6 0.6 0.2 -0.8
Smoking Status 0.5 1.3 2.2 1.0 1.5 -0.8
Allergy or Eczema 0.2 0.5 1.4 0.2 -0.4 1.2
Cardiovascular Disease 1.9 6.2 11.7 1.9 -3.4 -1.8
Hypothyroidism (self reported) 1.6 3.6 6.7 1.6 -2.6 -1.2
Respiratory disease 0.9 2.0 3.9 1.0 -1.0 -2.0
Type 2 Diabetes (T2D) (2018) 1.8 3.3 7.0 1.4 -2.6 -1.1
Lung FEV1/FVC ratio 1.2 5.9 13.7 -1.7 1.1 3.7
Lung FVC 0.8 4.2 8.8 -1.9 3.0 0.7
Neuroticism 0.3 0.7 1.5 -0.4 0.8 1.2
Chronotype (morning person) 1.5 3.4 3.8 -1.8 2.0 1.8
Hair Pigment 0.1 3.8 4.4 -1.7 2.1 2.0
Tanning 0.1 1.1 2.2 0.9 0.6 -1.5
Hand grip strength (left) 0.3 0.9 1.9 0.6 -1.4 -0.6
Number of treatments/medications taken 1.0 1.8 3.0 1.7 -1.5 -0.3
Average weekly spirits intake 0.4 0.5 0.9 -0.9 0.8 0.2
Sensitivity / hurt feelings 0.8 1.4 2.8 -0.6 1.7 1.0
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.7 -0.0 0.1 1.7
Hearing difficulty/problems: Yes 2.2 3.3 5.7 0.6 -2.0 -2.4
Relative age of first facial hair 0.2 0.4 0.9 -0.4 -0.9 0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.8 -0.1 -1.4 -0.4
Ever used hormone-replacement therapy (HRT) 0.6 0.8 0.8 0.8 -0.9 -0.9
Ever had hysterectomy (womb removed) 4.2 4.7 6.1 1.9 -2.5 -2.1
Systolic blood pressure, automated reading 0.1 0.4 0.9 -0.4 0.9 -0.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.2 -0.7 1.0 1.1
Angina 0.4 0.6 1.6 -0.2 -1.3 -0.2
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.4 0.1 0.2
Vitamin and mineral supplements 1.1 1.5 2.3 -1.5 1.4 -0.4
Supplements: Zinc 0.4 0.4 0.6 0.6 -0.8 -0.5
Medication: Co-codamol 0.7 0.8 1.8 -0.3 1.3 0.6
Medication: Metformin 0.1 0.1 0.1 -0.4 0.3 0.2
Diabetes (father) 0.0 0.1 0.1 -0.2 0.0 -0.4
Diabetes (mother) 6.5 8.3 9.9 3.1 -2.6 -2.8
Severe depression (siblings) 1.3 1.4 2.6 0.4 -1.2 -1.6
Pack years adult smoking proportion 0.4 0.6 1.7 -0.0 -0.1 -1.3
Impedance of leg (right) 0.2 1.0 1.9 -1.4 -1.0 0.5
Leg fat-free mass (left) 0.3 1.8 3.8 2.0 1.2 -0.2
Trunk fat percentage 0.1 0.5 1.0 0.2 1.0 0.5
Hand grip strength (right) 0.3 0.7 1.1 0.9 -1.0 -0.6
Townsend deprivation index at recruitment 1.3 1.8 2.9 -0.7 -1.7 -1.4
Current tobacco smoking 0.5 0.8 1.6 0.5 0.6 -1.3
Average weekly fortified wine intake 0.3 0.3 0.6 0.4 -0.4 -0.8
Maternal smoking around birth 0.7 1.1 1.6 0.3 1.3 1.2
Fed-up feelings 0.7 1.2 3.1 -0.2 0.7 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 0.3 -0.5 -0.0
Relative age voice broke 0.3 0.4 1.0 0.3 -1.0 -0.4
Taking other prescription medications 0.6 0.9 1.8 0.1 -1.3 1.0
Age when periods started (menarche) 0.5 1.2 2.3 -0.7 1.5 0.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.2 0.7 -1.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 -0.1 -0.1 -1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 0.3 0.0 -0.8
Qualifications: CSEs or equivalent 1.5 2.0 3.2 -0.9 1.8 1.4
Serious illness, injury or assault to yourself 0.2 0.2 0.5 0.7 -0.0 -0.4
High blood pressure 0.7 1.9 3.6 1.2 -1.9 -0.8
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.2 -1.2 0.8 1.8
Multivitamins +/- minerals 1.2 1.5 3.0 1.7 -1.2 -0.5
Stomach or abdominal pain in last month 0.2 0.2 0.4 0.7 0.4 -0.3
Supplements: Glucosamine 0.5 0.7 1.0 1.0 0.0 1.0
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 0.9 0.4 -0.9 -0.9
Medication: Atenolol 0.0 0.1 0.2 0.1 0.0 0.4
Medication: Levothyroxine sodium 1.3 2.2 4.4 0.9 -2.1 -1.2
Sitting height 0.5 3.3 5.0 2.2 -1.0 -2.0
Chronic bronchitis/emphysema (father) 1.3 1.5 2.5 0.5 -1.3 -1.6
High blood pressure (mother) 3.2 4.4 9.4 3.1 -1.3 -1.5
Body mass index (BMI) 0.1 0.4 1.0 1.0 0.5 -0.0
Impedance of leg (left) 0.2 0.9 2.2 -1.5 -0.3 0.7
Leg predicted mass (left) 0.3 1.7 3.8 2.0 1.1 -0.2
Trunk fat mass 0.1 0.5 1.2 1.1 0.7 0.1
Waist circumference 0.2 0.7 1.9 1.4 0.2 -0.2
Number of incorrect matches in round 0.5 0.8 1.4 0.3 -1.2 -0.9
Past tobacco smoking 0.4 0.8 1.9 -0.4 -1.4 -0.6
Alcohol usually taken with meals 0.3 0.4 1.1 1.0 -0.2 0.4
Nervous feelings 0.0 0.1 0.1 0.4 -0.4 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.0 -0.1 -0.2 -0.1
Hearing difficulty/problems with background noise 0.7 1.1 2.7 0.0 -1.6 -0.7
Hair/balding pattern: Pattern 2 1.2 1.5 4.3 -2.1 -0.2 0.3
Had menopause 0.0 0.0 0.1 -0.3 -0.1 0.2
Had other major operations 0.3 0.3 0.6 -0.8 -0.4 -0.5
Forced vital capacity (FVC) 0.5 1.9 5.3 -0.4 2.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 1.6 0.1 -0.2 -1.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.9 1.4 -0.8 -0.3
Qualifications: None of the above 0.1 0.2 0.4 -0.5 -0.6 0.0
Financial difficulties in last 2 years 0.3 0.4 0.6 -0.6 0.5 0.8
Mouth/teeth dental problems 0.2 0.3 0.8 -0.9 0.2 0.1
Heart attack 2.6 3.3 6.3 0.6 -2.5 -1.8
Allergy 0.1 0.2 0.3 -0.0 -0.4 -0.6
Pain all over the body in last month 1.1 1.2 1.8 -1.0 0.9 1.3
Diabetes (self-reported) 0.3 0.5 1.3 0.3 -1.1 -0.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 0.5 -0.7 0.6 0.7
Medication: Ramipril 1.4 1.8 4.4 0.3 -2.1 -0.9
Medication: Simvastatin 1.5 2.1 6.0 -0.3 -2.5 -0.6
Fluid intelligence score 0.2 0.3 0.5 0.7 0.6 0.5
Illnesses of siblings 2.0 2.8 4.5 -2.1 1.6 1.1
Neuroticism score 0.9 1.8 3.7 -0.9 0.9 1.9
Weight 0.3 1.4 3.5 1.9 0.7 -0.3
Impedance of arm (right) 0.3 1.5 2.6 -1.6 0.6 1.3
Arm fat percentage (right) 0.1 0.4 0.5 0.7 0.5 0.6
Trunk fat-free mass 0.7 4.1 9.8 3.1 -0.7 -1.4
Hip circumference 0.1 0.5 0.9 1.0 0.7 0.3
Time employed in main current job 3.1 3.5 5.8 -2.4 1.4 1.7
Alcohol intake versus 10 years previously 0.9 1.3 1.9 0.4 -1.4 -1.4
Father’s age at death 0.6 0.8 2.2 -1.5 -0.0 -0.6
Worrier / anxious feelings 0.1 0.1 0.4 -0.6 -0.1 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.0 0.4 -1.0 -0.6
Falls in the last year 2.4 3.2 5.2 1.9 -1.0 -2.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.3 -0.5 -0.6
Number of live births 0.4 0.6 1.8 1.3 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 6.4 -0.7 2.5 1.8
Pulse rate 1.7 2.9 4.2 -1.3 2.0 1.7
Happiness 0.5 0.6 1.1 1.1 -0.5 -0.5
Noisy workplace 1.0 1.3 2.0 0.5 -1.3 -1.4
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 0.0 -0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.0 -1.4 -1.2 -0.4
Mouth/teeth dental problems: Dentures 1.8 3.1 3.9 -1.3 2.0 1.9
Asthma 0.1 0.2 0.4 -0.2 0.6 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.1 0.1 0.3 0.2 -0.1
Medication: Cholesterol lowering 0.7 1.1 3.1 -0.0 -1.8 -0.5
Depression (self-reported) 1.2 1.5 2.7 1.3 -1.6 -0.4
Medication: Lansoprazole 1.1 1.2 3.1 0.4 -1.8 -0.7
Prospective memory result 2.6 3.2 5.1 1.1 -2.2 -1.8
Lung cancer (father) 0.0 0.0 0.1 0.3 0.1 -0.1
Illnesses of mother 1.6 1.9 3.4 -1.8 0.9 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 4.9 -1.3 2.2 1.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 -0.8 -0.1 0.1
Impedance of arm (left) 0.6 3.0 4.5 -2.1 1.5 1.4
Arm fat mass (right) 0.2 0.7 2.0 1.4 0.5 -0.0
Trunk predicted mass 0.7 4.1 10.1 3.2 -0.7 -1.3
Standing height 0.2 1.5 4.0 2.0 0.6 -0.6
Length of working week for main job 0.7 0.8 1.9 0.5 -1.4 -0.5
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.7 0.4 -0.3
Breastfed as a baby 0.6 0.8 0.9 1.0 -0.9 -0.8
Tense / ‘highly strung’ 1.3 2.1 3.2 1.8 -1.2 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.2 3.4 1.9 -1.3 -1.2
Hair/balding pattern: Pattern 4 0.8 1.9 4.0 1.2 -2.0 -0.5
Birth weight of first child 2.7 4.9 6.5 2.5 -2.1 -2.0
Peak expiratory flow (PEF) 1.6 3.6 7.7 -0.7 1.6 2.8
Pulse wave reflection index 0.9 1.1 2.5 0.4 -1.6 -0.8
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.0 0.6 -1.1 -1.4
Loud music exposure frequency 0.1 0.1 0.4 -0.1 -0.6 0.0
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.1 0.4 0.0 0.2
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.1 1.4 -1.8 -1.0
Blood clot in the leg (DVT) 0.4 0.5 1.0 1.0 0.4 0.5
Medication: Paracetamol 0.5 0.9 2.2 1.5 0.4 0.6
Headache pain in last month 1.9 3.2 3.9 2.0 -1.8 -1.5
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 4.6 -1.1 2.2 0.6
Glaucoma (self-reported) 0.1 0.1 0.2 -0.4 -0.2 0.4
Gout (self-reported) 3.2 4.4 6.1 2.5 -2.3 -1.4
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 4.7 1.4 -2.2 -1.2
Medication: Amlodipine 0.6 0.8 1.9 0.4 -1.4 -0.6
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.1 -0.0 1.5 0.6
Birth weight 0.1 0.2 0.4 0.7 0.2 0.5
Chronic bronchitis/emphysema (mother) 2.2 2.5 4.0 2.0 -1.5 -1.2
High blood pressure (siblings) 6.8 9.8 12.6 3.5 -3.2 -2.5
Forced vital capacity (FVC), Best measure 0.4 1.4 3.2 -0.9 1.8 0.5
Body fat percentage 0.1 0.3 0.4 0.5 0.6 0.4
Leg fat percentage (right) 0.0 0.1 0.2 0.4 -0.3 0.4
Arm fat-free mass (right) 0.3 1.8 4.5 2.1 0.4 -0.8
Exposure to tobacco smoke outside home 0.1 0.2 0.4 -0.1 0.2 -0.6
Comparative body size at age 10 0.6 1.7 3.0 -0.8 1.7 1.3
Number of full brothers 0.5 0.6 1.0 -1.0 0.8 -0.4
Worry too long after embarrassment 0.5 0.8 1.1 -1.1 0.7 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.8 4.5 2.0 -1.7 -2.1
Wheeze or whistling in the chest in last year 4.2 7.4 10.9 2.0 -3.3 -2.7
Number of children fathered 0.3 0.4 0.7 0.4 -0.4 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 3.8 4.4 6.2 2.5 -1.8 -2.0
Age at first live birth 0.3 0.5 1.1 -1.1 0.5 -0.2
Pulse wave peak to peak time 0.4 0.4 1.3 1.1 0.1 -0.1
Health satisfaction 1.3 1.7 2.2 1.1 -1.5 -1.3
Shortness of breath walking on level ground 1.7 2.0 2.6 1.0 -1.6 -1.5
Qualifications: College or University degree 0.0 0.0 0.1 -0.0 0.1 0.3
Eye problems/disorders: None of the above 0.2 0.3 0.6 0.2 -0.3 -0.8
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.1 0.2 -0.7 -1.0
Emphysema/chronic bronchitis 2.0 2.2 3.0 1.3 -1.4 -1.7
Medication for pain relief, constipation, heartburn 0.6 1.1 2.2 -1.5 1.0 0.1
Neck or shoulder pain in last month 0.1 0.2 0.2 -0.4 0.4 0.4
Medication: Blood pressure 1.0 1.8 3.8 1.1 -2.0 -0.4
Angina (self-reported) 0.6 0.7 1.9 0.2 -1.4 -0.4
Migraine (self-reported) 6.6 8.2 10.9 2.5 -3.3 -2.7
Medication: Ibuprofen 0.2 0.2 0.5 0.3 0.7 0.2
Medication: Allopurinol 2.0 2.7 4.1 2.0 -1.8 -0.9
Medication: Omeprazole 0.1 0.1 0.3 0.3 -0.5 -0.2
Medication: Seretide 50 evohaler 0.7 0.8 1.3 0.7 -0.8 -1.2
Mean time to correctly identify matches 0.2 0.4 1.0 0.2 -0.3 -1.0
Heart disease (mother) 0.4 0.5 1.2 -0.3 -0.2 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.7 0.7 1.3 -0.3
Whole body fat mass 0.2 0.7 1.7 1.3 0.6 0.0
Leg fat mass (right) 0.1 0.6 1.7 1.3 0.0 -0.1
Arm predicted mass (right) 0.4 2.3 6.0 2.5 0.3 -0.9
Pulse rate, automated reading 2.9 9.3 14.5 -2.3 3.8 2.8
Alcohol intake frequency. 1.2 2.7 5.7 2.4 -1.0 -1.2
Comparative height size at age 10 0.2 0.9 2.0 1.4 -0.8 -0.5
Number of full sisters 0.7 0.9 1.7 0.1 1.3 1.0
Suffer from ‘nerves’ 0.9 1.4 1.6 -1.2 1.3 1.1
Overall health rating 0.5 1.0 3.0 -0.1 -1.7 -0.4
Chest pain or discomfort 1.9 2.8 4.3 1.1 -1.7 -2.1
Had major operations 2.7 3.1 3.2 -1.8 1.8 1.8
Age at last live birth 0.1 0.1 0.2 0.0 -0.4 -0.4
Family relationship satisfaction 0.6 0.8 1.9 1.4 -0.6 -0.0
Leg pain on walking 0.4 0.5 1.1 -0.1 1.1 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 1.9 -0.9 1.2 1.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.5 -0.6 0.7 0.6
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.9 0.6 0.6 1.4
Medication: Aspirin 1.5 2.0 4.9 0.4 -2.2 -1.0
Supplements: Vitamin C 0.4 0.4 1.0 1.0 -0.5 -0.1
Knee pain experienced in last month 1.2 1.9 4.0 1.3 -2.0 -0.3
Hypertension (Self-reported) 0.8 2.3 4.5 1.4 -2.1 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.0 1.0 -0.4 -0.6
Illnesses of father: Heart disease 2.1 3.0 3.3 1.7 -1.8 -1.7
Illnesses of siblings: Diabetes 0.8 0.9 1.3 -1.1 0.6 1.1
Smoking status: Previous 0.3 0.5 1.1 0.1 1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 0.1 0.5 0.3
Whole body fat-free mass 0.5 2.6 6.9 2.6 0.3 -0.9
Leg fat-free mass (right) 0.4 1.9 3.6 1.9 1.5 -0.2
Arm fat percentage (left) 0.1 0.5 0.9 0.5 0.9 0.7
Average weekly red wine intake 0.7 1.1 1.5 -0.9 0.9 1.2
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.3 -0.4 1.0 1.5
Mood swings 0.5 0.8 2.0 0.0 0.7 1.4
Loneliness, isolation 0.8 1.2 3.1 -0.4 0.4 1.8
Long-standing illness, disability or infirmity 0.2 0.3 0.4 -0.3 0.6 0.6
Ever had bowel cancer screening 1.4 1.6 2.5 0.8 -1.6 -1.4
Diabetes diagnosed by doctor 0.4 0.6 1.5 0.2 -1.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 0.9 -0.1 -0.3
Friendships satisfaction 1.1 1.3 3.7 1.9 -0.6 -0.1
Qualifications: nursing, teaching 0.4 0.6 1.4 -0.2 1.2 0.6
Commuting to job workplace: Walk 0.8 0.9 1.5 0.4 -1.2 -1.0
Eye problems/disorders: Cataract 0.1 0.2 0.4 0.0 0.7 0.0
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 1.3 1.1 -1.0 -1.2
Medication for cholesterol 0.4 0.6 1.8 -0.2 1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 3.0 4.7 0.9 -2.2 -1.8
Back pain experienced in last month 0.9 1.3 1.8 1.3 -1.1 -1.0
Mineral and other dietary supplements 4.0 5.4 11.4 -1.8 3.4 1.2
Breast cancer (self-reported) 0.0 0.0 0.0 -0.2 -0.1 0.1
Asthma (self-reported) 0.1 0.2 0.3 -0.4 0.6 -0.4
Osteoporosis (self-reported) 1.6 2.0 4.0 1.2 -2.0 -0.8
Osteoarthritis (self-reported) 0.4 0.5 0.7 0.8 -0.6 -0.6
Medication: Aspirin 1.2 1.6 4.0 0.2 -2.0 -0.9
Medication: Gliclazide 0.0 0.0 0.1 -0.4 -0.1 -0.1
Illnesses of father: None of the above (group 1) 0.4 0.5 0.7 -0.4 0.7 0.8
Smoking status: Current 0.5 0.8 1.7 0.6 0.6 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 -0.0 0.9 0.4
Whole body water mass 0.5 2.6 7.0 2.6 0.2 -0.9
Leg predicted mass (right) 0.4 2.0 3.5 1.9 1.5 -0.1
Arm fat mass (left) 0.2 0.7 1.8 1.4 0.6 -0.1
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 0.5 -1.3 0.6
Average weekly champagne plus white wine intake 0.2 0.2 0.5 -0.3 0.4 0.7
Miserableness 0.1 0.2 0.4 -0.3 0.6 0.3
Guilty feelings 1.9 2.9 6.3 -0.2 1.5 2.5
Wears glasses or contact lenses 0.8 0.9 2.0 -1.4 -0.8 0.1
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.5 0.6 0.1
Hearing aid user 2.0 2.3 4.2 -2.0 1.6 0.3
Mother’s age at death 1.1 1.3 2.2 -1.5 0.0 1.3
Financial situation satisfaction 1.2 1.4 2.0 1.4 -1.1 -1.0
Tinnitus: Yes, now most or all of the time 2.0 2.3 3.5 -0.7 1.7 1.9
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.3 0.0 0.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.4 0.1 0.4
Medication: Blood pressure 0.5 1.0 1.4 1.1 -1.2 -0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.3 1.5 -1.4 -0.3
Supplements: Fish oil (including cod liver oil) 2.5 3.3 6.7 1.3 -2.6 -1.2
High cholesterol (Self-reported) 0.4 0.7 2.0 -0.0 -1.4 0.3
Medication: Bendroflumethiazide 0.4 0.6 0.8 0.6 -0.9 -0.9
Medication: Paracetamol 0.4 0.7 1.7 1.3 0.3 0.5
Medication: Lisinopril 0.8 1.0 1.8 -0.7 1.3 1.0
Medication: Atorvastatin 0.6 0.8 1.0 0.8 -1.0 -0.8
Illnesses of father: High blood pressure 1.3 1.6 3.3 1.8 -0.9 -0.9
Alcohol drinker status: Never 0.6 0.7 2.1 1.4 -0.0 -0.4
Ever smoked 0.4 0.8 1.6 0.2 1.3 0.8
Basal metabolic rate 0.4 2.2 6.1 2.5 0.4 -0.7
Leg fat percentage (left) 0.0 0.2 0.3 0.4 0.2 0.5
Arm fat-free mass (left) 0.5 2.3 6.0 2.4 0.0 -1.0
Number of operations (self-reported) 0.7 1.1 2.4 -1.5 0.8 0.5
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.6 0.3 -0.3
Irritability 1.7 2.8 4.2 -2.0 1.3 1.6
Risk taking 0.3 0.4 0.7 0.8 -0.2 -0.8
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.5 0.7 -0.5 -0.4
Fractured/broken bones in last 5 years 0.6 0.8 1.8 -0.0 -0.8 -1.4
Age started oral contraceptive pill 0.5 0.6 1.4 0.6 -0.4 -1.2
Diastolic blood pressure, automated reading 0.1 0.2 0.6 0.1 0.8 0.3
Ever depressed for a whole week 0.7 0.9 2.5 1.6 0.3 -0.3
Unable to work because of sickness or disability 0.7 0.9 2.0 0.5 -0.7 -1.4
Commuting to job workplace: Cycle 2.5 3.0 3.2 -1.7 1.7 1.8
Myopia 0.2 0.4 1.0 0.1 -0.2 -1.0
Vascular/heart problems diagnosed by doctor 1.2 3.2 6.7 -1.4 2.6 1.1
Cholesterol lowering medication 1.1 1.6 4.8 0.0 -2.2 0.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.2 -0.6 -0.0
Pain experienced in last month 0.4 0.7 1.2 -0.4 1.1 -0.9
Supplements: Calcium 2.0 2.2 4.3 1.5 -2.1 0.3
Basal cell carcinoma (self-reported) 1.1 1.4 2.0 -0.8 1.4 1.2
Heart attack/myocardial infarction (self-reported) 2.4 3.1 5.6 0.5 -2.4 -1.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 0.8 0.6 0.5
Heart disease (siblings) 0.3 0.3 0.7 0.5 -0.8 -0.3
Alcohol drinker status: Previous 0.1 0.1 0.1 0.3 -0.3 0.1
Pack years of smoking 0.4 0.6 1.6 -0.3 -0.2 -1.3
Impedance of whole body 0.4 2.1 4.1 -2.0 0.8 1.3
Leg fat mass (left) 0.1 0.6 1.6 1.3 0.3 -0.1
Arm predicted mass (left) 0.5 2.5 6.4 2.5 -0.2 -1.1