TWAS hub - SEMA3C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1890	0.0330	1.7e-13	0.074	0.147	0.172	0.176	0.169	2.5e-09	1.8e-17	1.8e-20	6.9e-21	4.0e-20
2	ROSMAP	Brain Pre-frontal Cortex	0.0934	0.0280	1.1e-04	0.009	0.038	0.060	0.042	0.045	2.3e-02	9.7e-06	3.0e-08	3.9e-06	1.5e-06
3	YFS	Blood	0.0280	0.0107	2.5e-03	-0.001	0.005	0.000	0.006	-0.001	7.6e-01	4.8e-03	2.6e-01	3.6e-03	9.7e-01
4	TCGA	Cervical Squamous Cell Carcinoma	0.1100	0.0460	4.3e-03	0.003	0.027	0.018	NA	-0.004	2.2e-01	1.7e-02	4.4e-02	NA	5.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Commuting to job workplace: Cycle	4.0	4.9	7.3	2.7	2.1	-1.5	2.3
Sensitivity / hurt feelings	3.6	6.2	9.0	-3.0	-2.8	1.2	-2.6
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.4	6.1	-2.5	-2.3	0.5	-2.4
Medication: Ibuprofen	3.5	4.1	5.8	-2.3	-2.3	0.4	-2.4
Major Depression (MDD)	3.4	4.1	11.0	-1.3	0.7	3.3	-1.9
Medication: Lisinopril	3.3	4.3	9.6	-0.2	-0.1	2.7	-3.1
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	8.9	-1.1	-0.7	3.0	-1.8
Risk taking	3.1	4.5	7.3	-2.6	-0.5	-2.0	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	9.4	-1.7	-2.1	1.2	-3.1
Osteoarthritis (self-reported)	2.9	3.8	6.6	-2.1	-1.4	-2.6	-1.5
Commuting to job workplace: Public transport	2.9	3.5	5.5	-2.0	-1.1	1.8	-2.3
Diastolic blood pressure, automated reading	2.9	9.0	14.2	3.5	3.8	2.7	1.5
Age started oral contraceptive pill	2.8	3.5	6.8	0.8	1.9	-2.6	1.7
Medication: Gliclazide	2.6	2.9	6.4	1.3	1.7	-2.5	1.0
Number of live births	2.5	3.6	8.3	-2.3	-2.9	-0.8	0.5
Pulse wave Arterial Stiffness index	2.5	2.9	5.3	2.3	2.1	0.3	1.3
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	8.7	1.5	0.4	1.1	3.0
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	8.2	-2.1	-2.9	-0.2	-1.9
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	5.5	2.3	1.9	0.7	0.7
Supplements: Glucosamine	2.4	3.2	9.4	1.2	1.0	-3.1	1.0
Blood Red Count	2.3	22.3	41.1	6.4	4.7	1.3	5.0
Pulse wave peak to peak time	2.3	2.8	5.0	-2.2	-2.1	-0.1	-1.2
Body Mass Index (BMI) (2010)	1.9	2.6	4.8	1.9	1.4	-0.5	2.2
Blood Platelet Count	1.9	22.0	41.5	-3.8	-4.5	6.4	-3.5
Waist Hip Ratio (WHR)	1.9	8.5	18.1	2.7	1.4	2.6	-4.3
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.9	-1.0	-1.7	2.2	-1.0
Father’s age at death	1.9	2.5	4.8	2.2	0.5	-0.4	2.2
Illnesses of siblings: Diabetes	1.9	2.3	3.5	-1.9	-1.7	-0.3	-1.7
Hearing aid user	1.9	2.2	4.1	1.3	2.0	0.3	1.7
Leg pain on walking	1.8	2.3	6.0	1.0	1.5	-2.4	0.0
Prostate Cancer	1.7	2.4	4.6	1.6	2.1	-0.0	1.5
Crohns Disease (2012)	1.7	2.8	5.3	2.3	1.9	1.3	0.8
Medication: Metformin	1.7	2.4	5.0	0.8	1.7	-2.2	-1.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.5	-1.7	0.3	2.1	-0.9
Falls in the last year	1.7	2.3	4.0	1.4	2.0	-1.2	1.3
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.8	-1.3	-0.9	-1.5	-1.9
Supplements: Calcium	1.7	1.9	5.1	-0.3	-0.2	-2.2	1.6
Alzheimer’s Disease (in mother)	1.6	1.9	3.5	-1.9	-1.6	0.5	-1.1
Medication: Co-codamol	1.6	1.9	4.2	-1.2	-0.3	-1.3	-2.0
Number of full sisters	1.6	2.0	6.5	-2.5	-0.9	-0.5	-0.5
Family relationship satisfaction	1.6	2.0	3.0	1.6	1.7	-0.8	1.3
Medication: Atorvastatin	1.6	2.0	6.8	-0.5	-0.4	0.8	-2.6
Neuroticism (2016)	1.5	2.1	5.8	-1.4	-0.5	0.4	-2.4
Primary Biliary Cirrhosis	1.5	2.1	5.0	-2.2	-1.7	-0.6	-0.2
Breast cancer (self-reported)	1.5	1.8	6.5	0.1	-0.2	0.8	-2.6
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.7	-0.6	-0.5	-0.1	-2.4
Hair/balding pattern: Pattern 2	1.4	1.7	5.4	1.0	0.6	2.3	0.3
Had menopause	1.4	1.7	2.4	-1.5	-1.5	-1.0	-1.1
Asthma	1.4	2.7	5.8	-1.6	-1.5	0.4	-2.4
Tense / ‘highly strung’	1.4	2.3	5.7	-1.4	-0.6	-1.0	-2.4
Medication for cholesterol	1.4	2.1	4.8	-1.5	-2.2	1.1	-0.3
Mineral and other dietary supplements	1.4	1.9	6.3	-0.3	0.1	2.5	-1.1
Ever taken oral contraceptive pill	1.4	1.5	3.8	-0.1	1.1	2.0	-1.0
Relative age of first facial hair	1.3	2.6	5.1	-2.2	-1.3	0.5	-1.9
Systolic blood pressure, automated reading	1.3	3.9	6.6	2.6	2.3	1.7	-0.8
Hand grip strength (right)	1.3	3.7	7.1	2.5	2.7	0.5	1.0
Fed-up feelings	1.3	2.4	4.6	-2.2	-1.6	0.3	-1.5
Number of incorrect matches in round	1.3	2.1	3.8	-1.2	-1.7	-1.9	0.2
Neuroticism score	1.3	2.7	6.5	-1.6	-1.1	0.6	-2.5
Gout (self-reported)	1.3	1.7	3.6	0.8	1.6	-0.5	1.9
Had major operations	1.3	1.6	2.5	-1.6	-1.4	0.8	-1.1
Smoking status: Previous	1.3	1.9	4.4	-0.6	-0.9	1.4	-2.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.0	-1.2	-1.1	1.4	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.9	5.4	0.1	-1.2	2.3	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.3	-0.4	-2.3	0.1	0.2
Mother’s age at death	1.2	1.4	3.5	-0.7	-1.2	0.5	1.9
Eye problems/disorders: Glaucoma	1.2	1.4	2.7	1.1	1.6	0.8	0.9
High cholesterol (Self-reported)	1.2	2.2	5.4	-1.0	-1.5	-0.2	-2.3
Fractured/broken bones in last 5 years	1.2	1.6	3.9	0.9	1.1	-2.0	0.7
Myopia	1.2	1.8	5.4	0.5	0.2	-1.2	2.3
Smoking Status	1.1	2.7	7.2	-0.2	-0.3	2.7	-1.9
Average weekly fortified wine intake	1.1	1.3	2.4	1.0	1.5	-1.3	-0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.3	1.0	1.0	1.8	-0.1
Medication: Ramipril	1.1	1.4	2.9	1.4	1.7	0.5	0.5
Illnesses of siblings	1.1	1.6	2.9	1.7	1.3	1.0	1.0
Length of working week for main job	1.1	1.2	4.2	-2.1	-0.7	0.4	-0.2
Suffer from ‘nerves’	1.1	1.8	3.4	-1.3	-1.9	1.1	-1.0
Overall health rating	1.1	2.4	8.2	-0.7	0.8	-0.6	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.1	-2.0	-1.9	-0.1	1.2
Average weekly red wine intake	1.1	1.6	2.5	1.3	0.9	-1.6	1.1
Asthma (self-reported)	1.1	2.1	4.9	-1.4	-1.3	0.3	-2.2
Alzheimer’s Disease (in father)	1.0	1.0	1.8	0.6	1.1	-1.4	-0.9
Ovarian Cancer	1.0	1.3	2.7	-0.9	-1.2	-0.5	-1.6
Coronary Artery Disease (CAD)	1.0	1.2	1.9	-1.1	-0.6	1.4	-1.2
Systolic Blood Pressure	1.0	5.1	8.8	2.0	1.7	3.0	-2.2
Taking other prescription medications	1.0	1.5	2.9	1.3	1.0	-0.6	-1.7
Serious illness, injury or assault to yourself	1.0	1.2	2.7	0.7	1.6	-0.3	-1.2
Hearing difficulty/problems with background noise	1.0	1.5	5.7	-0.6	0.0	0.3	-2.4
Mouth/teeth dental problems	1.0	1.5	3.6	1.9	1.5	-0.1	0.4
Diabetes (self-reported)	1.0	1.6	5.0	-0.4	-0.3	-2.2	-1.1
Lung cancer (father)	1.0	1.2	3.0	1.0	1.7	1.0	0.1
Mood swings	1.0	1.9	5.5	-0.4	0.4	1.3	-2.4
Ever had bowel cancer screening	1.0	1.2	1.7	-1.2	-1.3	0.2	-1.2
Friendships satisfaction	1.0	1.3	3.3	-0.5	1.1	1.8	0.7
Financial situation satisfaction	1.0	1.2	3.1	-0.0	0.6	1.8	-1.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.2	-0.5	-0.7	-2.0	-0.3
Age at First Birth	0.9	1.3	2.9	-0.2	-0.4	1.5	-1.7
Fasting Glucose	0.9	1.1	2.1	1.0	1.5	1.1	-0.1
Severe depression (siblings)	0.9	1.0	1.6	1.1	1.3	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.0	1.3	0.1	1.1	-2.2
Stomach or abdominal pain in last month	0.9	1.2	2.2	0.8	1.2	-1.5	-0.5
High blood pressure (mother)	0.9	1.3	3.8	0.7	0.9	0.1	1.9
Had other major operations	0.9	1.0	2.2	1.5	1.1	0.3	0.8
Illnesses of mother	0.9	1.1	2.9	-0.3	-1.7	-0.5	-1.0
Peak expiratory flow (PEF)	0.9	2.1	3.9	1.5	-0.1	1.5	2.0
Worry too long after embarrassment	0.9	1.5	3.2	-0.2	-0.9	1.8	-1.4
Medication: Aspirin	0.9	1.2	2.2	0.7	1.5	-1.0	-1.1
Diabetes diagnosed by doctor	0.9	1.5	4.3	-0.4	-0.6	-2.1	-1.2
Back pain experienced in last month	0.9	1.2	1.9	-1.4	-0.9	-0.7	-1.4
Heart disease (siblings)	0.9	1.1	2.7	0.0	0.6	-1.1	1.6
Reaction Time	0.8	1.5	5.0	0.5	2.2	0.7	-0.4
Bipolar Disorder (2011)	0.8	0.8	2.6	0.6	0.0	1.6	0.5
LDL Cholesterol	0.8	1.3	4.1	-0.0	-0.3	-1.0	2.0
Lupus	0.8	1.3	1.7	-1.3	-1.2	1.2	-0.8
Angina	0.8	1.1	2.1	0.2	1.5	-0.1	-1.4
Medication for hormone replacement therapy	0.8	0.9	3.3	0.3	0.5	-1.8	0.0
Pack years adult smoking proportion	0.8	1.2	3.3	1.0	1.8	0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.8	-0.4	-0.3	-1.1	-1.7
Medication: Simvastatin	0.8	1.2	2.6	-1.2	-0.0	-0.8	-1.6
Impedance of arm (right)	0.8	3.5	7.5	-2.5	-2.7	-0.5	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.1	0.8	0.7	-0.9	-1.8
Pulse wave reflection index	0.8	1.0	1.3	0.9	0.9	1.1	1.1
Glaucoma (self-reported)	0.8	0.9	2.0	-0.2	0.5	1.2	1.4
Emphysema/chronic bronchitis	0.8	0.9	1.4	-0.2	1.0	1.0	-1.2
Age at last live birth	0.8	1.2	2.2	0.5	0.7	1.5	1.3
Loneliness, isolation	0.8	1.2	3.0	-1.1	-0.1	0.6	-1.7
Eye problems/disorders: Cataract	0.8	0.9	2.9	-1.7	-0.4	-0.4	-0.6
Medication: Aspirin	0.8	1.0	2.2	0.3	0.9	-1.0	-1.5
Medication: Bendroflumethiazide	0.8	1.3	2.1	1.1	1.1	1.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.9	0.7	1.7	-0.4	-0.7
Impedance of whole body	0.8	3.9	8.0	-2.6	-2.8	-1.0	-0.2
Heel T-Score	0.7	5.8	13.2	-1.0	-2.5	1.6	-3.6
Hand grip strength (left)	0.7	1.8	3.7	1.9	1.4	1.0	0.8
Hearing difficulty/problems: Yes	0.7	1.1	3.0	-0.3	0.8	0.9	-1.7
Diabetes (father)	0.7	0.8	1.9	0.2	0.8	0.9	1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	0.8	0.4	0.9	1.3
Chronic bronchitis/emphysema (father)	0.7	0.9	2.9	0.4	-0.0	-0.7	-1.7
Past tobacco smoking	0.7	1.4	3.0	0.2	0.6	-1.7	1.5
Qualifications: None of the above	0.7	1.5	2.8	-1.1	-1.0	-0.9	-1.7
Happiness	0.7	0.9	1.6	0.4	1.2	0.9	1.1
Depression (self-reported)	0.7	0.9	3.0	0.2	0.1	0.7	-1.7
Medication: Lansoprazole	0.7	0.8	2.3	0.4	0.2	-1.5	-0.9
Impedance of arm (left)	0.7	3.2	5.3	-2.2	-2.3	-1.3	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.2	0.2	-0.0	-0.6	2.0
Medication: Amlodipine	0.7	1.0	2.0	-0.1	0.7	1.2	-1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.1	-1.0	-1.0	1.0	-0.7
Angina (self-reported)	0.7	0.9	2.2	-0.1	1.1	-0.2	-1.5
Migraine (self-reported)	0.7	0.8	1.4	-1.2	-0.7	-1.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	-0.9	-1.1	-1.1	0.2
Long-standing illness, disability or infirmity	0.7	1.1	2.9	0.4	1.7	-0.9	-0.7
Medication: Blood pressure	0.7	1.4	3.6	1.3	1.9	0.5	0.3
Alcohol drinker status: Never	0.7	0.8	1.5	-1.2	-0.0	-0.6	-1.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.9	-1.6	-1.7	0.2	1.4
Cholesterol lowering medication	0.7	1.1	3.0	-0.8	0.2	-0.8	-1.7
Alcohol drinker status: Previous	0.7	0.7	1.3	0.9	0.5	0.7	1.1
Pack years of smoking	0.7	1.0	2.9	1.0	1.7	-0.2	-0.3
Crohns Disease (2017)	0.6	1.3	3.4	1.8	1.2	0.6	-0.1
HDL Cholesterol	0.6	1.1	3.5	-0.3	-1.9	-0.6	-0.6
Ulcerative Colitis	0.6	0.9	1.6	0.9	1.2	0.2	1.1
Blood White Count	0.6	4.1	13.3	-0.5	0.6	3.6	-1.6
Respiratory disease	0.6	1.4	3.7	-0.8	-1.1	-0.3	-1.9
Average weekly spirits intake	0.6	0.8	2.0	-0.4	1.4	0.8	-0.5
High blood pressure	0.6	1.6	2.4	1.5	1.5	0.3	-1.3
Medication: Levothyroxine sodium	0.6	1.0	2.0	-0.8	-1.4	-0.6	-1.0
Impedance of leg (left)	0.6	2.8	5.9	-2.3	-2.4	0.2	0.2
Nervous feelings	0.6	1.2	2.9	-0.1	-0.6	1.2	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.6	0.1	0.1	0.2	-1.9
Heart attack	0.6	0.8	2.2	0.2	1.5	-0.6	-0.7
Worrier / anxious feelings	0.6	1.1	3.0	0.4	-1.1	1.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.5	1.3	-0.2	1.5	1.9
Noisy workplace	0.6	0.7	1.2	0.9	0.8	0.6	1.1
Exposure to tobacco smoke at home	0.6	0.7	1.3	-0.5	-0.8	-1.1	-0.8
Neck or shoulder pain in last month	0.6	0.9	3.4	-0.0	0.1	-0.4	-1.8
Pulse rate, automated reading	0.6	1.9	2.8	1.4	1.7	0.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	0.3	0.7	1.5	0.3
Supplements: Vitamin C	0.6	0.7	2.5	-0.3	0.4	1.6	-0.3
Knee pain experienced in last month	0.6	1.0	3.8	-0.1	0.4	-1.9	0.1
Hypertension (Self-reported)	0.6	1.7	2.8	1.7	1.6	0.7	-0.9
Illnesses of father: Heart disease	0.6	0.8	2.1	0.1	0.9	-1.5	-0.3
Wears glasses or contact lenses	0.6	0.7	1.1	0.4	0.9	-1.1	-0.7
Illnesses of father: High blood pressure	0.6	0.7	1.0	0.7	1.0	0.6	-1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-0.3	-1.2	-0.8	-0.8
Ever depressed for a whole week	0.6	0.8	1.7	-0.2	1.3	1.2	0.3
Schizophrenia (2018)	0.5	1.1	4.3	-0.1	0.5	0.1	2.1
Irritable Bowel Disease (IBD)	0.5	1.3	3.6	1.9	1.1	0.4	-0.1
Mean Putamen Volume	0.5	0.5	1.1	-0.9	-1.0	-0.3	-0.5
Hypothyroidism (self reported)	0.5	1.2	2.7	1.6	0.5	-0.5	1.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.9	1.0	1.4	-0.8	-0.7
Number of treatments/medications taken	0.5	0.9	1.7	1.3	0.8	-0.7	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.1	0.3	-1.3	-0.7
Diabetes (mother)	0.5	0.6	2.5	0.1	0.2	-1.6	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.0	-0.2	0.4	1.4	-1.4
Alcohol usually taken with meals	0.5	0.8	1.0	1.0	0.9	-1.0	0.7
Financial difficulties in last 2 years	0.5	0.6	1.5	0.8	0.7	-0.2	-1.2
Allergy	0.5	1.1	2.6	0.5	-0.1	-1.3	1.6
Hip circumference	0.5	2.1	7.5	-0.7	0.4	-0.2	2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.2	1.5	0.5	1.5	1.1
Birth weight of first child	0.5	1.0	2.6	0.8	0.5	-1.6	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.9	-0.4	0.6	-0.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.1	1.5	1.0	-0.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-1.1	-0.5	0.6	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	1.4	0.4	0.5	0.3
Exposure to tobacco smoke outside home	0.5	0.7	1.4	-0.9	-0.0	-0.8	-1.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	0.4	1.6	0.1	-0.9
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.9	0.4	-0.4	-1.1
Medication: Blood pressure	0.5	0.9	2.1	-0.0	-0.0	1.2	-1.4
Mean time to correctly identify matches	0.5	0.9	2.4	0.2	1.5	0.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.3	0.1	-0.9	-1.2	0.1
Chest pain or discomfort	0.5	0.7	1.5	0.3	1.2	0.2	-1.1
Osteoporosis (self-reported)	0.5	0.6	1.0	1.0	0.4	-0.5	1.0
Guilty feelings	0.5	0.7	2.8	-0.3	0.1	0.2	-1.7
Ever smoked	0.5	0.9	1.9	0.5	-0.2	1.4	-1.2
Average weekly beer plus cider intake	0.5	0.7	1.5	0.4	1.2	-0.1	-1.0
Unable to work because of sickness or disability	0.5	0.6	2.4	-0.2	0.1	0.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.8	0.4	-0.9	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	-0.6	0.2	1.4	0.1
Bipolar Disorder (2018)	0.4	0.6	1.4	0.6	1.2	-0.7	-0.3
Bipolar Disorder or Schizophrenia	0.4	0.9	2.2	0.3	1.2	-0.4	1.5
Alzheimer’s Disease (including proxy)	0.4	0.6	2.4	-0.3	-0.2	0.3	-1.5
HbA1C	0.4	0.5	1.5	-0.3	0.2	-1.2	-0.5
Blood Eosinophil Count	0.4	3.0	10.0	0.5	1.3	3.2	-0.4
BMI	0.4	2.4	4.3	1.2	1.8	0.6	2.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-1.1	0.2	-0.5	-0.9
Relative age voice broke	0.4	0.7	2.6	0.2	0.1	-0.3	-1.6
Time employed in main current job	0.4	0.5	0.7	0.8	-0.8	0.6	-0.6
Prospective memory result	0.4	0.5	1.1	0.0	-1.0	-0.5	-0.8
Birth weight	0.4	0.9	2.8	0.5	0.5	-0.5	1.7
Forced vital capacity (FVC), Best measure	0.4	1.5	4.1	1.2	0.4	2.0	0.6
Number of children fathered	0.4	0.4	1.5	0.2	-1.2	-0.1	-0.2
Heart disease (mother)	0.4	0.4	1.4	-0.6	0.2	-0.0	-1.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.4	0.0	0.3	1.4
Smoking status: Current	0.4	0.6	1.3	-0.0	0.9	1.2	-0.5
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	0.5	1.2	-0.8	-0.5
Miserableness	0.4	0.7	2.1	-0.3	0.6	0.5	-1.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.3	-0.2	0.6	1.8	0.4
Schizophrenia (2014)	0.3	0.6	1.7	0.1	0.7	-0.2	1.3
Triglycerides	0.3	0.4	1.5	-0.3	-0.2	1.2	0.2
Cardiovascular Disease	0.3	1.1	2.6	0.5	0.0	1.2	-1.6
Neuroticism	0.3	0.8	2.1	-0.8	-0.6	-0.0	-1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	0.6	-0.7	-0.7	0.1
Vitamin and mineral supplements	0.3	0.5	1.6	-0.4	0.0	1.3	0.3
Impedance of leg (right)	0.3	1.6	3.3	-1.8	-1.8	-0.0	0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	0.2	-0.3	-0.7
Multivitamins +/- minerals	0.3	0.4	1.2	0.2	-0.5	-1.1	-0.0
Waist circumference	0.3	1.2	3.1	1.1	1.8	0.4	0.5
Forced vital capacity (FVC)	0.3	1.0	2.6	0.5	-0.4	1.6	1.0
Pain all over the body in last month	0.3	0.3	0.6	-0.8	0.6	-0.3	-0.3
Fluid intelligence score	0.3	0.6	0.9	0.2	0.9	0.9	0.9
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.0	0.8	0.8	0.7
Pulse rate	0.3	0.5	1.3	0.7	0.5	-1.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	-1.1	0.0	-0.5	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.7	-0.3	0.3	-0.5	-1.3
Loud music exposure frequency	0.3	0.4	1.0	-0.3	0.1	0.7	-1.0
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.3	0.5	1.1	0.5
High blood pressure (siblings)	0.3	0.4	0.9	-0.6	-0.1	-0.6	-0.9
Arm fat-free mass (right)	0.3	1.4	1.8	1.2	1.4	1.2	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.3	0.3	0.4	-1.1
Health satisfaction	0.3	0.4	1.0	-0.2	1.0	-0.2	-0.8
Qualifications: College or University degree	0.3	0.9	1.3	-0.1	-1.2	-1.1	1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.5	-0.4	1.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.9	0.2	0.3	-0.7
Qualifications: nursing, teaching	0.3	0.5	0.9	-0.5	-0.8	-0.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.4	0.7	0.8	0.3
Irritability	0.3	0.5	1.8	0.2	0.5	0.1	-1.4
Arm predicted mass (left)	0.3	1.3	2.0	1.1	0.8	1.4	1.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	-0.8	0.0	0.1	-1.1
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-1.0	-0.6	0.1	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.7	0.5	-0.7	0.3
Ulcerative Colitis (UC)	0.2	0.4	1.0	1.0	0.5	0.4	-0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.3	0.6	1.0	0.7
Breast Cancer	0.2	0.5	1.2	-0.1	-0.6	0.6	-1.1
Height	0.2	3.7	8.0	-0.5	-2.8	2.3	-1.1
Allergy or Eczema	0.2	0.6	1.6	-0.3	0.7	0.1	-1.3
Lung FEV1/FVC ratio	0.2	1.0	2.3	0.8	-0.1	0.9	1.5
Chronotype (morning person)	0.2	0.4	1.1	1.0	-0.7	-0.3	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.1	-0.4	-1.0	-0.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.4	-0.6	0.7	0.4
Trunk fat percentage	0.2	0.8	1.8	-1.3	0.0	-1.0	0.6
Townsend deprivation index at recruitment	0.2	0.3	1.2	-0.0	0.1	1.1	-0.4
Current tobacco smoking	0.2	0.3	0.5	-0.5	0.3	0.7	-0.7
Medication: Atenolol	0.2	0.3	0.8	-0.4	-0.0	-0.9	-0.2
Body mass index (BMI)	0.2	0.8	2.6	0.5	1.6	0.1	0.6
Trunk fat-free mass	0.2	1.0	2.9	0.6	0.6	1.7	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.6	-0.8	-0.6	-0.6
Trunk predicted mass	0.2	1.1	3.3	0.5	0.5	1.8	0.6
Breastfed as a baby	0.2	0.3	0.6	-0.3	0.6	0.8	-0.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	-0.3	-0.4	-0.4	-1.3
Medication: Paracetamol	0.2	0.4	0.9	0.9	0.7	-0.3	-0.0
Headache pain in last month	0.2	0.4	1.0	0.6	0.4	1.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.0	0.3	0.9	-0.5
Leg fat percentage (right)	0.2	0.8	2.5	-0.0	0.9	-0.0	1.6
Number of full brothers	0.2	0.2	0.8	-0.0	-0.4	0.9	-0.2
Age at first live birth	0.2	0.3	0.8	0.4	0.0	0.9	-0.4
Medication: Omeprazole	0.2	0.2	0.6	0.4	0.1	-0.7	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.1	0.7	-0.2	-0.6
Leg fat mass (right)	0.2	0.9	2.0	0.0	1.2	0.1	1.4
Arm predicted mass (right)	0.2	1.0	1.2	0.9	1.1	1.1	1.0
Whole body fat-free mass	0.2	0.9	1.8	0.6	0.8	1.3	0.9
Commuting to job workplace: Walk	0.2	0.2	0.4	0.4	-0.4	-0.7	-0.3
Whole body water mass	0.2	0.9	1.6	0.7	0.8	1.3	0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.5	-0.4	-0.7	0.1
Medication: Paracetamol	0.2	0.3	1.1	1.0	0.4	0.1	-0.3
Basal metabolic rate	0.2	0.9	1.3	0.6	0.9	1.1	1.0
Leg fat percentage (left)	0.2	0.7	2.2	-0.4	0.5	0.1	1.5
Arm fat-free mass (left)	0.2	1.0	1.8	0.7	0.5	1.3	1.3
Number of operations (self-reported)	0.2	0.4	1.2	-0.3	0.2	0.3	-1.1
Pain experienced in last month	0.2	0.4	1.1	0.0	-0.6	1.0	-0.3
Leg fat mass (left)	0.2	0.6	1.6	-0.1	0.9	0.2	1.3
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.4	0.1	-0.3
Worry (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.7	-0.0	-0.2
Rheumatoid Arthritis	0.1	0.1	0.3	-0.2	-0.3	0.5	0.4
Lung FVC	0.1	0.6	1.2	1.1	0.8	-0.5	0.7
Hair Pigment	0.1	1.5	3.0	-1.7	-1.6	-0.7	-0.0
Supplements: Zinc	0.1	0.1	0.2	-0.1	0.3	0.4	0.3
Leg fat-free mass (left)	0.1	0.7	1.7	0.7	1.3	0.5	0.7
Age when periods started (menarche)	0.1	0.2	0.4	-0.5	-0.4	0.2	0.6
Sitting height	0.1	1.0	1.8	0.7	-0.6	1.4	1.1
Leg predicted mass (left)	0.1	0.7	1.5	0.6	1.2	0.6	0.7
Trunk fat mass	0.1	0.4	0.9	-1.0	0.2	-0.5	0.7
Weight	0.1	0.5	0.9	0.2	1.0	0.5	0.9
Arm fat percentage (right)	0.1	0.3	1.1	-1.1	0.1	-0.1	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	0.9	0.2	0.1	0.1
Standing height	0.1	0.8	1.6	-0.6	-1.3	0.8	0.7
Body fat percentage	0.1	0.6	1.2	-1.1	0.3	-0.4	0.9
Comparative body size at age 10	0.1	0.4	0.9	0.1	0.1	-1.0	0.8
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.5	-0.3	0.3	-0.2
Medication: Allopurinol	0.1	0.1	0.2	-0.4	-0.1	0.4	0.5
Whole body fat mass	0.1	0.4	0.8	-0.5	0.6	0.0	0.9
Alcohol intake frequency.	0.1	0.3	0.9	-0.2	0.1	0.9	-0.4
Comparative height size at age 10	0.1	0.3	0.9	0.2	-0.9	-0.1	-0.4
Leg fat-free mass (right)	0.1	0.6	0.9	0.6	1.0	0.7	0.8
Arm fat percentage (left)	0.1	0.3	0.6	-0.8	0.5	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	0.5	0.1	0.9	0.2
Leg predicted mass (right)	0.1	0.7	1.0	0.7	1.0	0.7	0.9
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	0.4	-0.1	-0.6	0.3
Tanning	0.0	0.2	0.6	0.8	0.4	0.4	0.1
Maternal smoking around birth	0.0	0.1	0.2	-0.3	-0.1	-0.2	-0.4
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	-0.5	-0.1	-0.0	-0.1
Arm fat mass (right)	0.0	0.2	0.4	-0.2	0.6	0.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.3	-0.4	-0.1	-0.0
Arm fat mass (left)	0.0	0.2	0.5	-0.1	0.7	0.0	0.4
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	-0.3	-0.2	0.2	0.1

Hub : Genes

SEMA3C

Models

Trait associations