Hub : Genes

SEMA4D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0340	5.2e-08	0.057	0.074	0.074	0.077	0.074	1.5e-07	2.3e-09	2.3e-09	1.2e-09	2.7e-09
2	GTEx	Artery Tibial	0.1307	0.0496	1.2e-03	0.014	NA	0.037	NA	0.032	2.6e-02	NA	6.7e-04	NA	1.4e-03
3	GTEx	Brain Caudate basal ganglia	0.2330	0.0870	4.9e-03	0.033	NA	0.113	NA	0.084	4.0e-02	NA	4.0e-04	NA	2.1e-03
4	GTEx	Cells Transformed fibroblasts	0.1720	0.0480	1.6e-05	0.160	NA	0.129	NA	0.141	4.6e-12	NA	7.0e-10	NA	9.6e-11
5	GTEx	Esophagus Muscularis	0.2190	0.0800	8.8e-04	-0.003	NA	0.017	NA	-0.004	5.5e-01	NA	3.2e-02	NA	8.5e-01
6	GTEx	Heart Left Ventricle	0.1723	0.0659	6.3e-03	0.019	NA	0.000	NA	0.012	3.3e-02	NA	3.1e-01	NA	7.1e-02
7	GTEx	Lung	0.0848	0.0300	6.5e-04	0.020	NA	0.020	NA	0.034	1.1e-02	NA	1.1e-02	NA	1.3e-03
8	GTEx	Whole Blood	0.0990	0.0370	1.0e-03	0.022	NA	0.018	NA	0.024	3.8e-03	NA	8.4e-03	NA	2.6e-03
9	NTR	Blood	0.0346	0.0116	1.1e-05	0.006	0.017	0.020	0.018	0.011	2.6e-03	2.1e-06	4.2e-07	1.5e-06	1.4e-04
10	YFS	Blood	0.2123	0.0278	0.0e+00	0.205	0.254	0.266	0.264	0.252	5.3e-65	1.0e-82	8.3e-87	4.4e-86	6.1e-82
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1140	0.0540	3.9e-03	0.006	0.025	0.008	NA	-0.002	1.3e-01	1.4e-02	1.1e-01	NA	4.3e-01
12	TCGA	Thyroid Carcinoma	0.0510	0.0210	7.7e-04	0.007	0.011	0.005	NA	0.005	6.1e-02	2.9e-02	9.9e-02	NA	8.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.3	2.1	8.7	3.0	-1.3	0.2	-1.7	0.8	1.9	0.8	1.0	0.1	2.0	-0.2	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.6	4.2	2.0	-1.2	0.1	0.0	-0.2	0.7	0.0	-0.4	0.7	0.6	0.0	-0.5
Depressed Affect (Nagel 2018)	0.7	1.5	3.3	-1.8	0.1	-1.7	0.4	0.4	-1.8	-0.9	-1.6	-0.4	-1.8	-0.9	0.2
Depression (Nagel 2018)	1.0	1.5	6.2	-0.0	-1.5	-0.5	-0.3	-0.5	-0.6	-1.2	-2.5	-1.7	-1.1	-0.9	-1.7
Intelligence (Savage-Jansen 2018)	1.0	3.2	11.4	0.6	0.7	1.6	0.7	-0.3	1.4	1.4	1.7	2.8	1.7	3.4	2.2
Neuroticism (Nagel 2018)	0.9	2.0	5.6	-1.9	0.4	-1.9	0.6	0.8	-1.9	-0.6	-2.0	-0.1	-2.4	-1.3	0.9
Schizophrenia (2018)	0.3	0.6	2.0	0.3	-0.2	-0.1	1.4	-0.9	-0.6	-0.6	-1.3	0.7	-0.8	0.2	0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	5.0	-1.0	0.8	1.4	0.9	-0.1	0.1	-0.5	-1.0	2.2	-0.6	0.2	0.5
Worry (Nagel 2018)	0.3	0.7	1.9	-1.4	0.0	-0.8	0.4	1.3	-0.3	0.8	-0.3	1.2	-0.5	-0.8	0.8
Alzheimer’s Disease (in mother)	2.4	2.8	6.5	-2.3	-1.2	-1.9	-0.1	-2.6	-1.4	-2.2	-0.9	-1.1	-1.4	-2.1	-1.1
Alzheimer’s Disease (in father)	0.6	0.6	2.4	-1.1	1.5	-1.2	-0.2	0.9	-0.7	0.2	-0.3	0.3	-0.7	-0.3	0.0
Alzheimer’s Disease (including proxy)	2.5	3.7	9.4	-3.1	-0.2	-2.2	-1.0	-1.8	-1.8	-2.4	-1.8	-0.6	-1.9	-2.7	-1.5
Crohns Disease (2017)	1.3	2.9	7.0	2.6	-1.5	0.5	0.4	-2.1	2.1	1.0	1.8	2.4	2.1	1.3	-0.1
Irritable Bowel Disease (IBD)	1.5	3.5	11.9	3.5	-2.1	0.8	0.2	-0.9	2.9	1.1	1.3	2.6	2.2	1.1	-0.4
Ulcerative Colitis (UC)	1.1	2.0	8.0	2.8	-1.5	0.6	0.3	0.6	2.3	0.7	0.3	2.1	1.3	0.4	-0.6
Major Depression (MDD)	0.9	1.1	3.2	1.4	-1.8	0.9	-0.4	-0.7	1.0	1.3	1.2	0.3	1.6	-0.1	0.1
Reaction Time	0.4	0.8	2.9	0.6	0.5	0.6	-1.6	-0.4	0.7	-0.1	-0.4	-0.8	0.5	-1.3	-1.7
Verbal and Numeric Reasoning (VNR)	1.0	2.3	10.4	1.4	-0.1	2.2	0.5	-0.6	1.4	1.3	1.2	1.4	1.2	3.2	1.0
Breast Cancer	0.3	0.7	2.4	1.2	0.4	0.2	-1.1	0.3	0.8	0.4	-0.2	0.7	0.7	-1.6	-1.0
Ovarian Cancer	1.9	2.5	9.7	1.3	-0.4	2.6	-2.0	-1.2	1.9	-0.3	0.6	0.3	1.2	-0.1	-3.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.5	5.1	-0.7	2.0	0.8	0.4	1.7	0.4	1.0	-0.0	0.5	-0.3	2.3	1.8
Bipolar Disorder (2011)	0.3	0.3	1.0	0.2	-1.0	-0.9	0.1	-0.5	-0.4	-0.3	0.3	-1.0	0.3	-0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.6	7.2	2.0	-0.8	0.3	-1.5	0.1	0.1	0.1	-0.1	-2.7	-0.2	-0.7	-2.2
Coronary Artery Disease (CAD)	0.6	0.7	2.3	0.5	-0.5	-0.8	1.2	-0.6	0.5	-1.1	-0.5	-1.5	-0.7	-0.3	-0.9
Crohns Disease (2012)	1.2	1.9	5.2	1.6	-0.9	-0.4	1.1	-1.3	1.2	1.4	2.3	2.0	1.8	0.4	0.4
Mean Putamen Volume	0.5	0.6	2.7	0.5	-1.3	-0.5	-0.7	-0.6	0.1	-0.2	0.3	0.1	0.7	-1.7	-0.8
Fasting Glucose	0.6	0.8	1.9	1.0	-1.3	0.6	-0.8	-1.4	1.4	0.1	-0.8	0.6	0.1	0.5	-0.7
HbA1C	4.8	5.3	18.7	2.4	-1.7	1.7	-4.3	-0.4	3.7	1.0	1.6	-0.7	2.9	-0.4	-2.7
HDL Cholesterol	0.8	1.4	5.6	0.1	0.7	0.8	0.3	0.8	0.5	1.5	1.6	2.4	1.4	0.5	1.4
LDL Cholesterol	0.2	0.3	2.1	-0.0	-0.2	1.4	-0.0	0.8	-0.3	0.2	-0.2	0.1	-0.0	0.1	0.5
Lupus	1.6	2.5	10.7	-0.3	-1.2	-1.1	-1.1	-0.7	-1.2	-1.3	-1.2	-2.6	-1.1	-3.3	-1.5
Neuroticism (2016)	0.3	0.4	2.7	-0.9	0.3	-1.6	-0.2	0.3	-0.2	-0.1	-0.5	0.6	-0.4	-0.6	-0.4
Primary Biliary Cirrhosis	0.5	0.7	3.1	0.7	-0.8	-0.2	-0.7	-0.7	1.3	-0.2	0.6	1.8	0.7	0.3	-0.6
Rheumatoid Arthritis	0.8	1.1	3.9	-1.1	-0.0	-0.8	1.5	0.7	-2.0	0.0	-0.1	-0.6	-1.5	-0.2	1.2
Schizophrenia (2014)	0.3	0.7	2.4	0.9	-0.8	0.3	0.8	-1.5	0.4	-1.1	-1.2	0.7	-0.2	-0.5	-0.9
Triglycerides	0.1	0.2	1.0	-0.6	0.1	0.2	-0.7	0.1	0.3	0.4	-0.1	-0.5	0.5	0.3	-1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.2	0.6	-0.0	-0.2	-0.1	1.1	0.1	0.1	-0.2	-0.1	-0.6	-0.9	-0.8
Ulcerative Colitis	0.6	0.9	3.3	1.8	-1.1	-0.3	1.2	0.6	1.1	-0.6	-1.1	0.3	-0.1	1.1	0.1
Blood Eosinophil Count	0.5	3.5	7.5	-2.6	2.2	-0.1	2.4	0.1	-2.7	-1.5	-2.1	-1.5	-2.7	0.3	1.3
Blood Platelet Count	0.8	9.2	23.1	3.5	0.3	4.2	-0.3	2.9	3.2	4.0	2.3	-0.1	3.7	4.8	1.8
Blood Red Count	0.6	5.7	29.5	3.6	-2.5	5.4	-1.7	-1.3	2.8	-0.3	0.3	0.6	2.4	0.9	-0.7
Blood White Count	0.8	5.8	18.6	4.0	-1.6	4.3	0.4	1.4	1.3	1.1	-0.8	-2.2	1.4	4.2	1.5
Heel T-Score	0.2	1.3	3.8	-0.3	-0.0	1.7	-1.1	0.3	0.0	1.3	1.9	1.7	1.1	-1.1	-0.1
BMI	1.6	9.3	30.1	1.3	-1.6	-0.9	-1.5	-3.1	-1.0	-4.2	-3.8	-5.5	-3.0	-2.6	-3.9
Height	0.3	5.4	21.1	-2.5	2.0	-1.6	3.0	1.2	-1.6	2.0	1.9	3.0	0.0	0.7	4.6
Waist Hip Ratio (WHR)	1.0	4.5	12.7	-1.4	-0.6	-1.0	1.3	-0.9	-3.0	-2.9	-3.2	-2.9	-3.6	0.1	0.4
Systolic Blood Pressure	1.0	5.2	12.7	1.3	-0.6	-0.5	3.0	3.2	-1.0	3.6	2.1	2.3	0.9	2.2	3.5
Smoking Status	0.4	0.9	2.5	-1.2	-0.1	-1.3	1.6	0.5	-1.5	0.5	0.1	0.3	-0.1	0.8	1.4
Allergy or Eczema	0.4	1.0	3.0	1.2	-0.9	-1.1	0.6	-1.7	1.2	-1.4	-0.1	1.2	-0.2	0.4	-0.4
Cardiovascular Disease	0.2	0.7	1.8	1.0	-0.9	1.1	1.3	1.4	0.3	0.4	-0.1	0.3	0.2	0.9	0.7
Hypothyroidism (self reported)	0.4	1.0	2.7	-1.0	-0.6	-0.9	-0.4	-1.1	-0.9	-1.2	-0.8	-0.0	-1.6	-1.1	-1.2
Respiratory disease	0.5	1.2	3.2	1.8	-0.2	-0.6	-0.3	-0.6	0.5	-1.4	-1.5	-1.0	-1.2	-1.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.9	-0.3	-0.9	0.3	0.5	-0.9	-0.8	-2.0	-1.7	-1.6	-1.6	-0.2	-0.5
Lung FEV1/FVC ratio	0.4	2.0	10.4	1.9	0.4	0.6	0.8	-0.6	0.3	1.9	3.2	0.4	1.8	-0.0	1.4
Lung FVC	0.6	3.0	13.2	-0.4	0.3	1.6	0.6	0.2	1.1	1.4	1.9	3.6	1.7	1.7	2.6
Neuroticism	0.8	1.8	5.7	-1.7	-0.2	-1.3	0.6	-0.2	-1.4	-1.6	-2.4	0.0	-2.3	-1.2	-0.0
Chronotype (morning person)	1.9	4.4	13.2	2.6	-1.9	-0.1	-1.2	-1.0	1.1	-1.9	-1.8	-3.1	-0.8	-3.0	-3.6
Hair Pigment	0.1	2.6	10.2	2.6	-3.2	0.3	0.0	-0.1	-2.1	-0.2	-0.7	-2.7	-0.9	-0.9	-0.6
Tanning	0.2	1.9	4.1	-1.5	1.8	-0.8	-0.1	1.9	-0.4	2.0	1.5	1.7	0.9	1.2	1.0
Hand grip strength (left)	0.3	0.7	3.6	0.7	-0.0	1.9	-0.7	0.2	0.5	0.5	0.5	1.2	1.2	0.3	-0.2
Number of treatments/medications taken	2.2	3.9	9.5	-1.6	-1.1	-1.8	1.1	-1.5	-1.9	-3.1	-3.1	-2.8	-2.5	-0.6	-0.1
Average weekly spirits intake	1.8	2.2	6.1	0.2	-2.1	-1.5	1.0	-1.9	-0.2	-2.5	-1.6	-1.7	-1.7	-0.4	-0.8
Sensitivity / hurt feelings	3.0	5.1	13.7	-2.4	1.1	-3.7	1.4	-0.6	-3.1	-1.9	-3.1	-0.5	-3.5	-1.9	0.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	7.4	0.6	-1.2	-0.5	0.3	0.1	-0.5	-1.0	-2.7	-1.2	-1.6	0.1	-1.0
Hearing difficulty/problems: Yes	0.9	1.3	4.8	-2.0	1.0	1.1	0.8	-2.2	-0.5	-0.8	-0.5	0.0	-0.2	1.6	0.6
Relative age of first facial hair	1.0	2.1	4.4	-2.0	2.1	-1.6	1.1	-1.9	-0.8	-1.8	-1.3	0.4	-1.8	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	8.6	-2.2	-0.9	-1.6	0.9	0.1	-1.6	-2.3	-2.5	-2.9	-2.7	0.1	-0.5
Ever used hormone-replacement therapy (HRT)	2.2	2.8	9.5	0.9	0.2	1.0	-1.9	1.0	2.5	1.5	1.2	2.6	3.1	1.1	-0.0
Ever had hysterectomy (womb removed)	0.3	0.3	1.2	0.2	-0.9	-1.0	-0.4	0.1	-0.4	0.1	-0.2	-0.7	-0.3	-1.1	-0.5
Systolic blood pressure, automated reading	0.5	1.6	4.9	0.0	1.6	-1.1	2.2	1.4	-1.5	1.5	0.3	1.0	-0.0	0.6	1.4
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	5.2	-2.3	1.9	-1.2	1.8	-0.5	-1.1	-1.4	-0.5	1.2	-2.2	-0.0	1.3
Angina	0.5	0.7	4.5	-0.7	-0.3	-0.5	0.2	-2.1	-0.7	-0.0	1.1	-0.3	-0.1	-0.7	-0.5
Medication for hormone replacement therapy	0.7	0.7	4.4	0.1	-0.8	-0.5	0.2	2.1	-0.2	0.8	-0.4	0.4	0.4	1.1	1.0
Vitamin and mineral supplements	1.0	1.3	4.5	1.0	-0.0	0.7	-0.6	2.1	0.9	1.8	2.0	0.2	0.9	-0.4	-0.2
Supplements: Zinc	2.3	2.5	6.8	-2.4	0.9	-0.4	0.7	-1.5	-2.6	-2.0	-2.0	-0.4	-2.0	-1.3	-0.4
Medication: Co-codamol	1.0	1.2	7.4	0.4	-1.0	-1.5	0.0	0.0	-0.7	-0.3	-0.9	-2.7	-1.0	-0.7	-0.7
Medication: Metformin	3.6	5.1	15.0	-1.6	0.2	-1.5	1.4	-2.0	-2.3	-3.5	-3.2	-2.8	-3.9	-0.1	0.1
Diabetes (father)	0.4	0.5	1.7	1.1	-0.3	0.4	-1.3	0.9	0.8	0.7	-0.1	-0.8	-0.2	-0.3	-0.5
Diabetes (mother)	0.2	0.2	0.6	0.2	-0.3	-0.0	0.5	0.2	-0.3	0.2	-0.6	0.6	-0.8	-0.7	-0.3
Severe depression (siblings)	0.4	0.4	1.2	-0.9	0.1	0.3	0.5	0.8	-1.0	0.2	-0.3	0.8	-0.5	-0.2	1.1
Pack years adult smoking proportion	2.8	4.3	16.5	-1.8	-0.1	-2.5	-1.1	-0.1	-2.3	-1.4	-1.0	-3.1	-1.6	-4.1	-1.9
Impedance of leg (right)	0.7	3.6	10.4	-1.6	2.1	-0.7	0.7	2.5	0.1	2.5	1.9	3.2	1.8	0.4	2.4
Leg fat-free mass (left)	0.2	0.9	2.0	0.7	-0.8	-0.6	-0.4	-0.9	-0.2	-1.4	-1.1	-1.1	-1.3	-0.8	-1.4
Trunk fat percentage	1.8	7.3	17.3	-0.8	-0.4	-2.4	0.9	-1.9	-2.9	-3.8	-3.7	-3.3	-4.2	-2.8	-1.9
Hand grip strength (right)	0.1	0.3	0.7	0.1	-0.7	0.8	0.6	-0.4	-0.5	-0.5	0.1	0.4	-0.2	0.7	0.7
Townsend deprivation index at recruitment	0.9	1.3	3.9	0.9	-1.1	0.8	1.2	-0.9	-0.1	-1.5	-1.8	-0.5	-0.9	2.0	-0.0
Current tobacco smoking	0.7	1.1	4.4	0.0	-0.1	-1.2	-0.5	1.9	-0.7	2.1	1.4	0.0	0.9	-0.6	0.1
Average weekly fortified wine intake	0.8	0.9	3.3	0.3	0.5	-0.5	1.8	0.0	-0.8	0.1	-1.1	-0.5	-0.9	1.2	1.6
Maternal smoking around birth	1.1	1.6	5.0	-2.2	0.9	-2.0	-0.0	0.4	-1.4	-1.0	-1.7	-0.6	-1.4	-0.6	-0.5
Fed-up feelings	0.5	1.0	3.5	-0.2	-0.5	-1.9	0.1	0.6	-1.0	0.0	-0.7	-1.2	-1.4	-1.7	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	10.7	-0.6	-1.7	0.0	1.0	-0.7	-1.7	-2.3	-3.3	-2.5	-2.4	-0.6	-0.8
Relative age voice broke	0.4	0.6	2.2	-0.1	0.9	-0.5	1.5	-0.9	-0.5	-0.4	-0.8	0.5	-1.2	-0.4	0.0
Taking other prescription medications	7.0	10.8	27.3	-2.7	-0.5	-2.7	1.0	-3.2	-3.4	-5.2	-4.7	-4.1	-4.7	-1.5	-1.0
Age when periods started (menarche)	0.9	2.2	7.2	0.8	-0.8	2.7	-0.3	-1.7	2.3	-0.3	0.5	1.6	2.0	1.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.4	1.2	-2.1	0.6	-0.8	-0.4	1.0	-0.3	-1.0	-0.9	0.5	0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.8	0.1	-0.8	-0.7	-1.2	-0.3	0.7	-0.1	0.3	-0.4	0.1	-1.7	-1.5
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	9.8	1.3	-3.1	2.0	-1.0	-1.6	0.7	-1.2	-0.4	-1.4	-0.4	-0.7	-1.6
Qualifications: CSEs or equivalent	0.4	0.5	1.3	1.1	-1.2	-1.1	0.7	0.8	-0.3	-0.0	-0.0	-0.6	-0.5	-0.4	0.4
Serious illness, injury or assault to yourself	2.5	3.1	6.4	-1.5	0.1	-1.1	1.6	-1.4	-2.4	-2.3	-2.5	-2.5	-2.3	0.4	0.1
High blood pressure	0.2	0.5	1.2	0.0	0.5	0.3	1.0	-0.4	-0.9	-0.9	-1.1	-0.8	-0.9	0.0	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.8	2.0	1.1	-1.0	-0.5	0.4	-1.3	1.2	-0.5	0.2	1.4	0.4	0.9	-0.2
Multivitamins +/- minerals	0.8	1.0	3.0	-0.1	-0.4	0.0	1.0	-1.2	-1.6	-1.3	-1.7	-0.8	-1.1	-0.3	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.8	-1.1	-1.0	-0.4	-0.7	0.1	-0.6	-0.6	-0.9	-0.5	-0.3	-0.4
Supplements: Glucosamine	2.5	3.3	7.9	1.8	-1.1	2.1	-1.9	-2.2	2.8	0.8	1.7	1.5	2.4	0.4	-1.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	5.3	0.2	-0.9	-1.0	0.3	-0.4	0.3	-0.8	-1.4	-2.3	-1.0	0.1	0.1
Medication: Atenolol	0.7	0.8	3.1	-0.8	0.8	-1.8	0.4	0.4	-1.3	-0.7	-0.1	-1.2	-0.9	-0.3	0.8
Medication: Levothyroxine sodium	0.6	1.0	2.8	-0.5	-1.1	-0.0	-0.2	-0.7	-0.3	-1.6	-1.0	-0.4	-1.4	-0.9	-1.7
Sitting height	0.3	2.2	6.0	0.4	0.8	0.2	0.7	1.8	1.0	2.0	1.7	2.5	1.7	1.0	1.9
Chronic bronchitis/emphysema (father)	0.8	1.0	2.6	-0.5	-0.1	-1.4	1.3	-1.6	-1.1	-0.7	-0.7	-0.7	-1.3	-0.6	0.8
High blood pressure (mother)	0.7	0.9	2.9	-0.5	-0.4	-0.2	0.5	0.3	-1.2	-1.0	-1.2	-1.2	-1.7	-0.9	1.0
Body mass index (BMI)	2.0	8.4	19.3	0.7	-1.8	-1.6	-1.1	-2.8	-1.4	-4.1	-3.5	-4.4	-3.3	-3.1	-3.9
Impedance of leg (left)	0.6	3.1	8.3	-1.8	1.9	-0.8	1.3	2.0	-0.9	1.8	1.6	2.9	0.9	0.3	2.9
Leg predicted mass (left)	0.2	1.1	2.4	0.6	-0.8	-0.6	-0.4	-1.0	-0.3	-1.6	-1.3	-1.3	-1.5	-0.9	-1.4
Trunk fat mass	1.5	6.5	14.7	-0.5	-0.7	-2.4	0.5	-2.1	-2.5	-3.8	-3.3	-3.1	-3.8	-2.8	-2.0
Waist circumference	2.2	7.9	17.4	-0.4	-0.7	-2.1	0.2	-2.5	-2.7	-4.1	-3.8	-4.1	-4.2	-2.2	-2.3
Number of incorrect matches in round	0.9	1.5	3.9	-0.6	-0.1	-1.4	-0.0	-0.7	-1.1	-1.8	-1.7	-0.8	-1.1	-2.0	-1.5
Past tobacco smoking	0.7	1.4	3.9	1.0	-0.1	1.5	-1.5	1.6	0.4	1.2	1.1	-2.0	0.3	-1.0	-0.7
Alcohol usually taken with meals	1.6	2.5	7.6	0.2	0.9	0.7	-2.7	-2.6	1.6	-1.8	-0.9	-1.4	0.5	-0.1	-2.5
Nervous feelings	0.4	0.8	3.5	-0.7	0.5	-0.1	0.9	1.9	-0.4	1.2	-0.3	0.8	-0.5	0.4	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.9	-0.2	-1.4	-1.1	-0.7	-1.1	0.3	-0.7	-0.8	-0.5	-0.6	-1.0	-0.6
Hearing difficulty/problems with background noise	0.3	0.4	1.7	0.3	0.2	1.3	0.2	-1.1	0.1	-0.3	-0.8	0.3	0.1	1.2	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	0.1	-1.0	0.9	-0.1	-0.3	-0.8	-1.2	-1.3	-0.8	-1.1	-0.1	-0.0
Had menopause	0.5	0.6	2.3	-0.4	1.3	0.4	0.2	0.5	0.7	0.7	0.4	1.5	0.7	0.9	0.4
Had other major operations	1.1	1.3	4.0	0.1	-2.0	-0.7	-0.8	-1.2	-0.8	-1.1	-0.2	-1.2	-1.0	-1.9	-0.9
Forced vital capacity (FVC)	1.1	4.1	13.3	-0.6	1.5	1.9	-0.6	1.2	1.4	2.4	2.8	3.6	2.6	1.5	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.1	0.7	-1.4	-1.0	-0.7	-0.2	1.0	-0.0	1.0	-0.6	0.2	-1.8	-0.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.0	-0.6	0.8	0.7	-0.9	0.1	0.7	1.2	1.3	1.4	1.1	1.7	0.5
Qualifications: None of the above	0.7	1.5	5.3	-1.8	-0.3	-1.8	0.7	0.4	-0.8	-0.9	-2.3	-1.0	-1.4	-0.5	-0.5
Financial difficulties in last 2 years	1.1	1.5	4.1	-1.3	-0.7	-0.8	-1.1	-1.3	-0.1	-2.0	-1.7	-1.8	-0.8	-0.3	-1.2
Mouth/teeth dental problems	0.7	1.0	3.7	0.1	0.9	0.1	1.8	1.1	-1.9	-0.1	-0.6	0.4	-1.1	0.5	1.2
Heart attack	0.3	0.4	1.3	-0.1	0.5	0.0	0.6	0.9	-0.6	1.1	0.7	0.2	0.4	0.8	0.6
Allergy	0.2	0.6	1.2	-1.1	1.1	1.0	-1.0	0.8	-0.5	0.6	0.2	-0.8	0.3	-0.5	-0.4
Pain all over the body in last month	1.6	1.7	4.1	-0.1	1.4	-1.0	0.4	1.3	-0.1	2.0	1.2	1.8	1.8	1.2	1.6
Diabetes (self-reported)	1.0	1.6	4.5	-0.2	-0.6	-0.5	1.0	-1.8	-1.0	-2.1	-1.1	-1.9	-1.8	-0.3	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	0.3	1.1	0.3	-0.5	0.8	0.6	0.5	0.4	0.8	0.7	0.4	0.2
Medication: Ramipril	1.5	2.0	6.6	-0.9	-1.3	-1.5	2.0	-0.8	-2.6	-0.5	-0.1	-1.2	-2.0	-0.3	1.4
Medication: Simvastatin	0.5	0.8	3.0	-1.1	0.2	0.7	1.3	0.4	-0.7	0.4	0.7	0.5	0.2	1.7	1.3
Fluid intelligence score	1.5	3.1	11.0	1.5	-0.3	2.2	-0.1	-0.2	2.6	1.4	1.2	2.1	2.1	3.3	0.6
Illnesses of siblings	0.6	0.8	4.1	0.4	-0.7	0.0	0.3	-2.0	0.1	-0.9	1.0	1.5	-0.2	-0.8	-0.4
Neuroticism score	0.8	1.6	3.8	-1.5	0.4	-1.6	0.9	-0.5	-1.2	-1.3	-1.9	1.0	-1.9	-1.0	0.0
Weight	0.7	3.3	7.2	0.0	-0.7	-1.6	-0.3	-1.8	-1.3	-2.7	-2.2	-2.4	-2.4	-1.9	-2.0
Impedance of arm (right)	0.7	3.2	10.1	-2.0	1.9	-0.7	2.2	1.7	-1.6	1.8	1.0	2.1	-0.0	1.3	3.2
Arm fat percentage (right)	2.2	8.7	17.4	-0.7	-1.0	-2.8	0.1	-2.4	-2.8	-4.0	-3.6	-4.1	-4.2	-3.2	-2.7
Trunk fat-free mass	0.1	0.5	1.5	0.7	-0.9	-0.2	-1.2	-0.6	1.1	-0.5	0.1	-0.3	0.3	-0.5	-1.0
Hip circumference	0.9	3.8	8.4	-0.2	0.2	-1.8	0.2	-1.7	-1.6	-2.9	-2.7	-2.4	-2.8	-1.9	-2.0
Time employed in main current job	0.6	0.7	2.3	-1.5	1.4	1.4	-0.1	-0.5	0.1	-0.2	-0.1	1.4	0.4	0.3	-0.3
Alcohol intake versus 10 years previously	1.1	1.6	5.1	1.9	-1.2	0.8	-1.2	-0.8	1.4	-0.6	-1.2	-2.2	-0.2	0.1	-1.6
Father’s age at death	0.3	0.4	1.3	-0.6	1.0	1.2	0.1	-0.5	-0.2	0.0	0.4	-1.0	-0.2	0.2	0.1
Worrier / anxious feelings	0.2	0.4	1.8	0.5	0.1	-0.3	-0.2	0.8	0.8	0.4	-0.4	1.4	0.6	0.8	0.1
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	12.2	0.4	-1.4	-1.2	0.8	-1.3	-1.5	-2.6	-3.5	-2.4	-2.6	-0.6	-1.0
Falls in the last year	2.9	3.9	9.1	-2.3	-0.0	-2.9	1.6	-1.2	-3.0	-1.5	-1.4	-1.3	-2.7	-2.5	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	6.2	-0.7	1.2	-2.5	0.6	0.5	-0.9	1.1	1.4	-0.3	-0.1	-0.1	0.7
Number of live births	1.7	2.5	6.7	-1.7	1.2	-2.5	2.4	-0.2	-2.6	-0.3	-0.5	-0.1	-2.0	-0.4	1.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	9.5	-0.1	1.6	1.9	-0.3	1.1	1.2	2.5	3.0	3.1	2.8	1.8	2.0
Pulse rate	0.4	0.7	2.0	0.9	-0.3	1.3	0.2	1.2	-0.3	1.0	0.3	-0.1	0.2	1.2	1.4
Happiness	1.3	1.6	4.2	-1.6	2.0	-0.6	-0.4	2.0	-0.8	1.8	0.8	1.9	0.1	-0.3	0.5
Noisy workplace	0.4	0.5	2.4	0.3	0.4	0.4	0.7	-0.1	-1.6	-0.3	-0.6	-1.3	-1.0	0.1	0.2
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.8	1.7	-1.3	0.6	-0.1	-1.2	2.8	0.8	2.6	2.4	1.9	1.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	5.3	0.8	-1.0	2.3	-0.9	-1.2	1.0	-0.4	0.5	0.1	0.6	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-1.1	-0.2	-0.7	-0.9	-1.0	0.5	-0.6	0.0	-0.8	0.1	-1.1	-0.7
Asthma	0.9	1.8	4.6	1.5	-0.6	-1.5	0.8	-1.1	0.3	-2.1	-2.1	-1.3	-2.0	-0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.6	1.7	-2.0	0.8	-1.7	-2.1	1.6	-0.7	-0.4	-0.9	1.2	-1.1	-1.9
Medication: Cholesterol lowering	0.4	0.7	2.9	0.4	-1.1	0.2	-0.0	-0.8	-0.1	-1.3	-0.7	-1.7	-0.2	-0.1	-1.0
Depression (self-reported)	1.5	1.8	5.7	-1.1	0.5	-0.6	1.5	0.2	-2.0	-1.3	-1.9	-0.0	-2.4	-0.8	1.1
Medication: Lansoprazole	1.0	1.1	3.6	-1.1	-0.5	-0.2	0.0	-1.9	-0.1	-1.7	-1.0	-1.4	-1.4	-0.3	0.3
Prospective memory result	0.9	1.1	3.4	-0.9	1.4	-0.6	0.6	0.9	-0.7	-0.6	-1.2	-1.8	-1.6	-0.5	-0.2
Lung cancer (father)	1.1	1.3	4.6	-0.5	-0.1	-0.5	-2.1	-0.5	1.5	0.3	0.1	0.6	1.6	-0.7	-2.0
Illnesses of mother	1.8	2.2	5.4	1.5	0.4	1.4	-0.1	1.4	1.9	1.8	1.3	1.1	2.3	2.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	14.6	-0.0	1.5	2.5	0.4	0.8	1.0	2.8	3.1	3.8	2.8	2.7	2.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	-0.8	0.3	-0.8	0.2	0.2	-1.0	1.2	1.3	1.0	0.2	-1.1	1.0
Impedance of arm (left)	0.7	3.3	8.9	-2.3	2.4	-0.4	2.3	1.9	-2.0	1.5	0.3	1.5	-0.5	1.3	3.0
Arm fat mass (right)	1.5	6.2	13.8	0.2	-1.3	-1.8	-0.4	-2.2	-1.8	-3.5	-3.2	-3.7	-3.2	-2.4	-2.8
Trunk predicted mass	0.1	0.5	1.3	0.6	-0.9	-0.3	-1.2	-0.7	1.0	-0.6	0.1	-0.4	0.3	-0.5	-1.0
Standing height	0.5	4.5	14.4	-1.1	2.1	0.0	1.4	1.6	0.4	2.5	2.4	3.8	1.7	2.0	3.4
Length of working week for main job	0.5	0.6	2.5	1.0	-1.6	-0.5	-0.8	0.5	0.2	-0.3	0.0	-1.3	0.2	-0.3	-0.9
Exposure to tobacco smoke at home	1.1	1.2	2.6	1.5	-1.4	-0.5	-0.8	-0.3	0.6	-1.0	-1.1	-1.6	0.3	-1.4	-1.6
Breastfed as a baby	3.1	3.8	9.1	2.5	-3.0	2.4	-1.6	-2.4	2.0	-1.8	-1.4	-1.6	0.6	0.1	-2.1
Tense / ‘highly strung’	0.3	0.6	1.5	-0.7	-0.2	-1.0	0.1	0.2	-0.8	0.1	-0.3	1.1	-1.0	-1.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	6.7	-1.7	1.0	-0.9	0.6	-0.8	-1.5	-1.8	-1.9	0.4	-2.6	0.1	0.9
Hair/balding pattern: Pattern 4	0.4	1.1	2.5	1.3	-1.0	-0.4	0.6	-1.6	1.4	1.1	1.4	0.7	1.1	0.3	-0.3
Birth weight of first child	1.6	2.8	13.0	-0.6	1.7	0.3	1.1	1.9	0.6	1.4	0.4	1.9	0.1	3.6	2.6
Peak expiratory flow (PEF)	0.3	0.7	3.2	-1.4	1.8	-0.4	0.2	-0.2	-0.7	0.0	0.8	0.4	0.6	0.6	1.0
Pulse wave reflection index	0.5	0.6	2.5	-0.1	-1.2	-1.6	-0.4	-0.1	-0.1	0.1	0.7	0.8	0.5	-1.4	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.6	0.1	0.0	0.5	-0.1	-0.1	-1.1	-0.3	-1.3	-0.6	-1.0	-0.7	-0.5
Loud music exposure frequency	0.8	0.9	3.5	-0.3	0.4	0.1	-0.5	0.8	0.8	0.9	1.5	1.9	1.5	0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.5	1.1	-0.1	-0.3	-0.2	-0.7	1.0	0.7	2.1	2.1	0.8	-0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.2	-1.8	1.4	-0.3	0.5	-0.1	-0.8	-0.4	-0.8	-0.5	-0.8	1.5	0.7
Blood clot in the leg (DVT)	0.3	0.3	0.9	0.1	-0.4	-0.9	-0.5	0.6	0.0	0.6	0.9	-0.8	0.1	-0.5	0.6
Medication: Paracetamol	1.0	1.6	8.6	1.2	-2.9	-0.8	-0.2	-1.9	0.6	-1.5	-1.2	-0.6	-0.5	-0.2	-0.5
Headache pain in last month	1.2	2.0	4.8	-1.4	0.0	-2.2	0.1	-1.4	-0.9	-1.9	-1.7	-1.9	-1.8	-1.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.4	0.0	0.4	0.6	-0.7	0.2	1.4	1.8	1.8	2.1	1.4	0.6	0.4
Glaucoma (self-reported)	2.2	2.6	6.3	-2.0	2.3	-2.3	2.2	-0.4	-2.5	-0.8	-0.7	-0.1	-1.5	-0.4	1.5
Gout (self-reported)	1.8	2.5	8.9	0.8	-1.2	0.4	-1.8	-1.9	-0.1	-1.7	-0.8	-1.4	-1.3	-3.0	-2.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.7	-0.5	-0.7	-0.4	-0.8	-1.5	-0.6	-1.8	-1.0	-0.5	-1.4	-1.1	-1.9
Medication: Amlodipine	0.4	0.5	3.4	1.4	-0.0	0.1	0.4	-0.5	-0.0	0.2	-0.5	-1.8	-0.1	-0.4	-0.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.9	2.1	0.5	0.1	0.4	0.9	2.2	0.4	-0.3	2.0	1.3	2.0	1.2
Birth weight	0.5	1.1	4.1	-2.0	1.1	-1.6	1.5	-0.7	-0.2	-0.7	-0.1	1.1	-0.7	0.2	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.8	0.5	-0.1	-1.3	0.1	0.3	-0.3	0.1	-0.2	-0.3	-0.0	-0.7	-0.5
High blood pressure (siblings)	0.6	0.9	3.4	1.3	-0.0	0.2	-0.7	0.7	0.6	-0.3	-1.6	-1.8	-0.0	1.1	-0.5
Forced vital capacity (FVC), Best measure	1.4	5.3	19.0	-0.9	1.7	2.0	0.4	0.8	0.9	2.5	2.9	4.4	2.3	2.4	3.0
Body fat percentage	2.0	7.8	16.8	-0.7	-0.5	-2.8	0.4	-2.1	-2.9	-3.9	-3.6	-3.4	-4.1	-3.2	-2.3
Leg fat percentage (right)	1.8	6.5	14.2	-0.4	-0.8	-2.4	-0.9	-2.2	-1.4	-3.8	-3.2	-2.9	-2.9	-3.4	-3.4
Arm fat-free mass (right)	0.2	0.8	2.1	1.2	-1.0	-0.0	-1.1	-0.7	0.9	-1.0	-0.4	-0.5	-0.1	-1.1	-1.5
Exposure to tobacco smoke outside home	0.7	0.9	7.7	0.2	0.4	-1.0	-0.4	0.5	-0.0	-0.1	-0.2	-0.3	-0.0	-2.8	-1.4
Comparative body size at age 10	1.6	4.3	11.6	-0.2	0.3	-0.7	-0.8	-3.4	-0.3	-3.4	-2.5	-2.1	-1.6	-2.1	-3.1
Number of full brothers	0.3	0.4	2.8	0.8	-0.3	-0.2	0.4	1.7	0.5	1.0	-0.2	0.3	0.1	-0.3	0.3
Worry too long after embarrassment	0.8	1.4	4.6	-1.2	0.9	-1.2	0.6	1.4	-1.6	-0.3	-1.4	-0.5	-2.1	0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.3	-0.5	-1.3	0.5	0.9	-0.3	0.6	-0.1	0.4	1.8	-0.0	0.9	0.4
Wheeze or whistling in the chest in last year	0.7	1.2	6.5	1.6	-2.6	0.5	-0.7	-0.7	0.9	-0.7	-1.2	-0.5	-0.1	0.5	-0.7
Number of children fathered	0.4	0.5	1.7	-0.3	-0.1	1.2	-0.3	0.1	0.2	-1.3	-1.0	-0.3	-0.2	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	2.6	1.6	-1.0	-0.0	-0.3	-0.4	1.0	-0.1	-0.5	-0.2	0.2	0.1	-0.1
Age at first live birth	0.4	0.7	4.0	-0.5	2.0	0.8	0.3	-0.8	-0.2	-1.0	0.1	1.3	-0.3	0.0	0.3
Pulse wave peak to peak time	0.5	0.6	1.4	0.3	-0.1	0.9	-0.1	-0.3	1.0	-1.2	-1.2	-0.5	-0.1	1.1	-0.8
Health satisfaction	0.6	0.8	2.4	-1.6	0.2	-1.3	0.6	0.2	-1.5	0.3	0.1	-0.9	-1.2	0.1	0.7
Shortness of breath walking on level ground	0.7	0.9	3.6	-1.0	0.1	-1.9	0.6	0.1	-1.0	0.1	1.1	-0.8	-1.0	-0.7	1.1
Qualifications: College or University degree	0.6	1.8	5.8	0.0	0.9	2.4	0.3	0.4	0.5	1.3	1.5	0.8	1.0	2.4	1.8
Eye problems/disorders: None of the above	1.1	1.3	3.6	0.9	-1.9	1.2	-1.2	0.7	1.5	0.6	-0.1	0.2	1.1	0.0	-1.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.1	0.4	-0.2	-1.0	0.3	0.5	0.3	1.4	1.0	0.5	0.7	0.5	1.1
Emphysema/chronic bronchitis	1.2	1.3	7.4	-0.9	0.8	-0.2	1.4	1.1	-2.7	0.4	-0.2	-0.3	-1.2	-0.1	1.3
Medication for pain relief, constipation, heartburn	1.1	2.0	7.6	-0.6	2.8	0.3	0.3	2.3	0.6	1.6	1.4	1.7	0.7	0.9	0.9
Neck or shoulder pain in last month	1.3	1.8	5.9	-0.5	-2.4	0.5	0.2	-2.4	-0.4	-2.0	-1.3	-0.8	-1.2	-1.1	-0.6
Medication: Blood pressure	1.2	2.2	5.2	-0.4	-0.0	-0.3	1.3	-0.0	-2.3	-1.9	-2.2	-2.3	-2.3	-0.6	0.2
Angina (self-reported)	0.6	0.8	3.7	-1.1	-0.0	-0.7	0.6	-1.9	-1.2	0.0	1.2	-0.3	-0.4	-0.5	0.0
Migraine (self-reported)	0.6	0.7	1.8	-0.1	0.3	-1.1	0.4	-0.6	-0.4	-1.1	-1.0	-0.9	-1.2	-1.3	0.3
Medication: Ibuprofen	1.9	2.2	6.5	0.8	-2.4	0.6	-1.2	-2.5	1.1	-1.7	-1.2	-1.6	0.3	-0.9	-1.8
Medication: Allopurinol	1.8	2.4	4.2	1.1	-1.5	1.7	-1.4	-1.4	-0.3	-2.0	-2.0	-1.3	-1.5	-2.1	-1.6
Medication: Omeprazole	0.2	0.3	1.1	-1.1	-0.3	-0.8	0.9	-0.2	-0.4	-0.3	0.5	0.0	0.2	0.2	0.1
Medication: Seretide 50 evohaler	1.0	1.1	4.1	2.0	-1.4	0.9	-0.8	0.1	1.8	-0.9	-1.1	-0.6	0.4	0.2	-0.6
Mean time to correctly identify matches	0.4	0.8	3.3	0.8	-0.1	0.4	-1.0	-0.8	0.5	-0.5	-0.5	-0.6	-0.1	-1.6	-1.8
Heart disease (mother)	0.4	0.5	1.7	-0.8	0.1	-0.6	0.3	0.2	-0.8	-0.4	-0.5	0.8	-1.3	0.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.4	6.9	-1.8	1.9	-0.2	1.2	1.1	-1.4	2.0	1.6	1.6	0.7	1.1	2.6
Whole body fat mass	1.6	6.8	14.8	-0.4	-0.8	-2.5	0.4	-2.1	-2.4	-3.8	-3.3	-3.3	-3.9	-3.0	-2.2
Leg fat mass (right)	1.7	6.5	14.0	-0.2	-0.8	-2.2	-0.5	-2.3	-1.6	-3.7	-3.1	-3.1	-3.2	-3.3	-3.1
Arm predicted mass (right)	0.1	0.8	2.2	1.2	-1.1	-0.2	-1.0	-0.7	1.0	-0.9	-0.2	-0.4	-0.0	-0.9	-1.5
Pulse rate, automated reading	0.2	0.7	1.5	0.8	-0.8	-0.3	1.1	0.8	-0.8	-0.4	-1.2	-0.5	-1.2	0.6	1.0
Alcohol intake frequency.	0.3	0.8	2.1	-0.3	1.0	-0.9	1.4	-1.4	-0.7	-0.2	-0.4	-0.4	-1.1	1.3	0.3
Comparative height size at age 10	0.3	1.5	3.5	-1.2	1.6	-0.7	1.5	1.9	-1.2	1.1	0.2	1.6	-0.3	-0.1	1.6
Number of full sisters	0.9	1.1	4.5	0.3	-1.0	1.2	0.6	-0.2	-1.3	-1.0	-2.1	-1.2	-1.0	0.7	-0.2
Suffer from ‘nerves’	0.6	1.0	6.1	-2.5	0.6	-1.5	0.0	0.4	-1.0	-0.2	-0.4	-0.1	-0.9	-0.8	0.5
Overall health rating	2.3	4.9	11.5	-1.2	-1.6	-2.9	2.3	-1.2	-2.2	-2.5	-3.0	-2.8	-3.4	0.2	-0.1
Chest pain or discomfort	0.9	1.3	5.8	0.1	0.9	-0.0	0.7	0.8	-0.3	1.4	0.4	0.1	1.3	2.4	2.0
Had major operations	0.7	0.8	3.5	0.2	-0.7	0.2	0.2	-1.9	1.5	-1.4	-0.5	-0.0	0.1	0.5	-0.7
Age at last live birth	0.8	1.2	3.0	-0.5	1.7	-0.3	1.6	0.0	-1.2	-1.3	-1.4	0.5	-1.5	0.3	0.7
Family relationship satisfaction	0.5	0.6	1.6	-0.6	-0.7	1.3	0.2	0.8	0.2	0.9	0.4	1.0	0.7	0.6	0.9
Leg pain on walking	1.2	1.5	4.8	-1.1	-1.0	-1.5	-0.1	-2.2	-1.2	-1.1	-0.4	-1.0	-1.3	-1.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.4	0.1	-0.2	-1.2	-0.1	0.7	-0.8	-0.5	-0.8	-1.5	-0.0	0.3	-0.5
Commuting to job workplace: Car/motor vehicle	2.3	2.7	7.6	-1.9	-0.0	-2.8	0.4	-2.2	-1.5	-2.2	-1.0	-0.0	-2.0	-2.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.3	1.0	0.2	-0.9	0.6	1.3	-0.1	1.8	1.4	1.4	0.9	-0.7	0.8
Medication: Aspirin	0.8	1.1	4.2	1.1	-2.0	-0.4	-0.6	-1.3	0.6	-1.2	-0.3	-1.4	-0.2	0.0	-1.1
Supplements: Vitamin C	0.8	0.9	3.9	-1.2	1.0	-1.0	0.5	-2.0	-0.5	-0.8	-0.6	0.6	-0.9	-0.8	-0.5
Knee pain experienced in last month	1.8	2.8	9.0	1.0	-1.9	0.9	-3.0	-0.4	1.1	-1.6	-2.1	-1.6	-0.2	-0.8	-2.9
Hypertension (Self-reported)	0.2	0.4	1.9	0.0	0.3	0.2	1.4	-0.6	-0.8	-0.8	-0.8	-0.4	-0.8	0.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.6	-1.4	0.7	-0.8	-0.1	0.8	0.6	0.8	1.4	1.9	1.0	-0.5	0.9
Illnesses of father: Heart disease	0.8	1.1	4.2	-1.1	0.2	-2.1	1.1	1.3	-1.2	0.1	-0.1	0.8	-1.4	-0.3	0.9
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-0.6	-0.9	0.3	1.1	0.6	-1.1	-0.2	-0.8	-1.1	-1.2	0.2	1.0
Smoking status: Previous	1.2	1.8	5.5	-1.2	0.1	-0.9	1.3	-2.2	-0.5	-2.4	-2.0	1.2	-1.2	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.0	-1.1	1.5	1.0	0.0	0.8	0.0	1.1	1.2	2.2	0.8	0.5	1.3
Whole body fat-free mass	0.1	0.5	1.2	0.7	-0.9	-0.4	-0.8	-0.8	0.4	-0.9	-0.2	-0.6	-0.3	-0.7	-1.1
Leg fat-free mass (right)	0.2	0.9	2.8	0.6	-0.8	-0.4	0.1	-1.0	-0.7	-1.4	-1.1	-1.2	-1.7	-0.5	-0.9
Arm fat percentage (left)	2.2	8.6	18.7	-0.5	-1.0	-2.3	0.0	-2.1	-2.8	-3.9	-3.9	-4.3	-4.1	-3.2	-2.9
Average weekly red wine intake	0.8	1.2	4.6	-0.9	-0.1	-0.9	0.5	-1.5	-0.4	-2.1	-1.6	0.1	-1.3	1.0	-0.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.4	0.4	1.9	0.0	0.4	0.8	-0.8	1.5	1.6	1.1	0.5	0.3	1.3
Mood swings	1.5	2.7	10.1	-1.3	1.0	-1.8	1.2	-0.1	-1.7	-2.1	-3.2	-1.1	-2.4	-0.7	0.2
Loneliness, isolation	0.3	0.5	2.7	0.5	-1.6	0.7	0.3	0.5	0.0	-0.2	-0.5	0.9	-0.3	0.4	0.7
Long-standing illness, disability or infirmity	3.4	5.2	13.6	-1.1	-1.7	-2.1	1.7	-0.8	-2.4	-3.1	-3.4	-3.7	-3.2	0.2	-0.2
Ever had bowel cancer screening	0.5	0.6	3.9	0.2	0.2	0.2	-0.4	-2.0	0.5	-0.5	-0.8	-1.1	0.2	0.9	0.3
Diabetes diagnosed by doctor	1.5	2.5	8.9	-0.7	-0.2	-0.3	0.8	-2.5	-1.1	-3.0	-1.9	-1.7	-2.3	-0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	7.0	-1.9	1.7	-0.6	1.8	-0.4	-2.4	-1.9	-2.6	-1.5	-2.6	0.2	1.0
Friendships satisfaction	1.1	1.4	4.7	-2.2	0.6	-0.7	2.0	0.4	-1.7	0.4	-0.5	0.9	-1.1	-0.2	1.5
Qualifications: nursing, teaching	0.4	0.6	5.4	-0.6	2.3	0.4	-0.7	-0.6	-0.4	-0.6	-0.0	-0.0	-0.6	-0.1	-0.4
Commuting to job workplace: Walk	1.4	1.5	4.5	-1.0	1.4	0.5	2.1	0.6	-0.3	0.2	-0.2	1.6	-0.4	2.1	1.8
Eye problems/disorders: Cataract	0.5	0.5	2.2	0.9	-0.4	-0.4	-0.7	0.1	0.2	1.1	1.5	0.1	1.0	0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	12.7	2.6	-3.5	1.5	-1.9	-1.2	3.6	0.7	1.3	0.3	1.9	0.0	-2.1
Medication for cholesterol	0.6	0.8	2.4	0.5	-0.3	-0.4	-0.5	-0.7	-0.6	-1.2	-0.9	-1.0	-1.0	-1.6	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	10.4	-3.2	1.9	-2.4	1.4	-0.3	-2.5	-1.4	-1.2	0.9	-2.4	-2.4	0.1
Back pain experienced in last month	0.6	0.9	3.4	0.2	-0.9	0.7	-1.8	-0.4	0.5	-0.1	-0.5	-0.7	0.6	-1.4	-1.7
Mineral and other dietary supplements	0.6	0.7	4.1	-0.6	0.1	-0.6	-0.2	2.0	-0.6	-0.5	-0.8	-0.7	-1.5	-0.3	-0.1
Breast cancer (self-reported)	0.8	0.9	2.6	-0.2	-0.3	-1.1	1.2	0.8	-0.8	1.6	1.0	-0.5	0.7	0.4	1.6
Asthma (self-reported)	0.8	1.5	4.4	1.7	-0.8	-0.9	0.7	-0.8	0.5	-1.8	-2.1	-1.3	-1.8	-0.3	0.0
Osteoporosis (self-reported)	1.4	1.8	10.0	2.2	-3.2	0.1	-0.2	-0.3	0.8	1.0	1.6	-1.0	0.7	0.6	-0.1
Osteoarthritis (self-reported)	0.9	1.2	4.2	0.1	0.1	0.6	-1.4	-1.2	1.2	-1.0	-1.7	-0.4	0.0	0.0	-2.1
Medication: Aspirin	1.0	1.3	3.6	0.6	-1.9	-0.7	-0.9	-1.3	0.2	-1.6	-0.7	-1.9	-0.5	-0.5	-1.5
Medication: Gliclazide	1.3	1.5	5.4	-1.1	0.4	-1.6	0.4	-2.3	-0.6	-2.1	-0.7	-1.4	-1.0	0.0	-0.5
Illnesses of father: None of the above (group 1)	2.1	2.6	10.3	1.8	-0.8	1.9	-2.8	-0.3	1.1	-0.2	-0.4	-1.1	1.6	-0.4	-3.2
Smoking status: Current	0.7	1.1	4.5	0.2	-0.3	-1.5	-0.3	1.7	-0.7	2.1	1.5	0.1	0.9	-0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.9	0.8	0.0	1.7	0.2	0.7	0.1	0.9	0.9	-0.5	0.7	1.7	0.2
Whole body water mass	0.1	0.5	1.2	0.8	-1.0	-0.4	-0.8	-0.7	0.5	-0.8	-0.2	-0.5	-0.3	-0.7	-1.1
Leg predicted mass (right)	0.2	0.9	2.7	0.6	-0.7	-0.4	0.1	-0.9	-0.7	-1.4	-1.1	-1.2	-1.6	-0.4	-0.9
Arm fat mass (left)	1.7	7.1	16.1	0.1	-1.3	-1.9	-0.5	-2.4	-2.0	-3.7	-3.4	-4.0	-3.4	-2.8	-3.0
Number of self-reported non-cancer illnesses	2.8	4.8	15.7	-0.0	-1.5	-0.4	0.4	-1.4	-1.6	-3.4	-4.0	-3.6	-3.0	-1.1	-0.7
Average weekly champagne plus white wine intake	0.7	1.0	2.3	-0.7	1.5	-0.9	-1.4	1.0	-0.5	1.5	1.1	0.4	0.5	-0.8	0.3
Miserableness	2.5	4.3	14.4	-3.8	1.0	-2.8	1.6	-0.6	-2.9	-1.6	-1.7	-0.6	-3.2	-0.4	0.9
Guilty feelings	0.6	1.0	4.3	-0.1	0.4	-0.8	0.3	0.1	-0.5	-1.1	-2.1	-0.8	-2.0	-0.6	0.3
Wears glasses or contact lenses	0.6	0.7	2.2	0.2	1.1	0.9	-0.3	-1.1	0.9	0.3	0.9	0.5	1.5	1.1	0.5
Ever taken oral contraceptive pill	0.5	0.5	1.6	-0.6	1.3	-0.7	0.9	0.1	0.1	0.4	1.0	0.4	0.4	0.8	0.9
Hearing aid user	0.7	0.8	5.3	-0.4	0.9	0.1	0.4	0.2	-0.3	-1.4	-2.3	-0.4	-0.6	-0.1	-0.4
Mother’s age at death	1.1	1.4	8.5	-0.0	1.5	2.9	-0.5	0.2	0.0	1.0	0.5	0.0	1.4	1.1	0.9
Financial situation satisfaction	3.2	4.0	9.6	0.9	0.1	0.9	-1.8	2.2	3.0	3.0	1.7	2.4	3.1	0.5	-1.3
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.1	-0.9	1.4	-1.0	1.6	1.3	-1.7	1.0	0.9	-0.4	-0.6	2.0	1.8
Commuting to job workplace: Public transport	0.8	0.9	3.0	0.2	0.5	1.6	0.1	1.7	0.2	1.1	-0.0	-1.5	0.4	1.1	-0.3
Eye problems/disorders: Glaucoma	1.3	1.6	4.4	-2.1	1.5	-1.6	1.4	-0.7	-1.9	-1.0	-0.3	-0.2	-1.3	-0.3	1.0
Medication: Blood pressure	0.2	0.4	1.1	0.3	0.5	0.8	0.4	-0.9	0.8	0.0	-0.2	-0.7	0.3	1.0	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.4	0.0	-1.5	0.1	0.2	-1.4	-0.3	-0.6	-0.9	-0.4	-0.2	0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.3	-0.2	1.4	0.4	0.3	-1.0	0.3	0.8	0.4	0.8	1.5	0.7	0.6
High cholesterol (Self-reported)	0.8	1.5	5.0	0.4	-1.7	2.2	-1.6	-0.6	0.9	-1.2	-0.6	-1.2	0.2	-0.2	-1.8
Medication: Bendroflumethiazide	0.8	1.3	9.5	0.6	0.0	0.5	0.2	0.2	-0.5	-0.6	-1.4	-3.1	-1.4	0.7	0.1
Medication: Paracetamol	1.1	1.7	6.1	0.1	-2.5	-1.4	0.5	-2.1	0.2	-1.8	-1.2	-1.3	-1.0	0.2	0.3
Medication: Lisinopril	1.1	1.4	4.5	1.8	0.2	1.1	-2.1	1.1	1.3	0.3	-0.1	-0.1	0.8	-0.4	-2.1
Medication: Atorvastatin	1.7	2.1	6.8	1.2	-1.9	-0.2	-0.9	-2.6	1.0	-1.9	-0.8	-1.6	-0.4	-1.0	-1.9
Illnesses of father: High blood pressure	0.5	0.6	1.9	-0.5	0.7	-0.7	1.4	0.3	0.0	0.3	0.6	0.9	-0.5	0.4	1.4
Alcohol drinker status: Never	1.5	1.8	6.7	0.3	0.5	-1.0	1.7	-0.4	1.0	1.7	2.0	2.6	0.9	1.0	1.1
Ever smoked	0.4	0.7	4.0	0.1	0.8	-0.9	0.9	-0.3	0.0	0.1	-0.3	2.0	0.6	1.0	0.8
Basal metabolic rate	0.2	0.9	1.8	0.7	-0.9	-0.7	-0.7	-1.0	0.0	-1.3	-0.8	-1.1	-0.9	-1.0	-1.4
Leg fat percentage (left)	2.2	7.9	18.5	-0.5	-0.9	-2.4	-0.5	-2.7	-2.1	-4.3	-3.5	-3.3	-3.5	-3.5	-3.2
Arm fat-free mass (left)	0.2	0.9	2.2	1.0	-1.1	-0.6	-1.1	-1.2	0.7	-1.1	-0.2	-0.7	-0.2	-1.2	-1.5
Number of operations (self-reported)	1.2	1.8	8.5	1.2	-2.9	0.2	-0.3	-2.0	1.2	-1.5	-0.8	-0.9	-0.2	-0.5	-1.4
Average weekly beer plus cider intake	1.1	1.6	6.9	1.3	-1.1	0.9	-0.7	2.6	0.8	2.1	1.3	0.2	1.0	-0.3	0.0
Irritability	0.4	0.6	2.5	0.3	0.1	-0.4	-0.2	-1.6	-0.3	-0.6	-0.3	0.9	-0.3	-1.5	-1.2
Risk taking	0.2	0.3	0.9	-0.0	-0.5	-0.2	-1.0	0.1	0.5	-0.5	-0.7	0.5	-0.3	-0.0	-0.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	5.1	1.2	0.1	0.9	-0.0	-1.4	0.7	-2.1	-2.3	-1.4	-0.1	-0.2	-1.3
Fractured/broken bones in last 5 years	0.5	0.7	1.5	-0.0	0.5	-1.1	0.8	1.2	-0.2	1.0	1.1	1.0	0.4	0.3	1.1
Age started oral contraceptive pill	0.7	0.9	4.8	0.0	-0.2	0.3	-0.1	-2.2	1.4	-1.1	-0.2	0.7	-0.1	1.3	0.1
Diastolic blood pressure, automated reading	0.4	1.3	4.5	0.2	1.5	-0.6	2.1	1.1	-0.9	1.2	0.6	1.8	0.4	0.3	1.0
Ever depressed for a whole week	1.8	2.2	6.9	-0.6	0.9	0.6	-0.5	1.2	0.3	2.6	2.2	2.4	1.2	1.3	1.7
Unable to work because of sickness or disability	0.5	0.6	3.0	-0.1	-0.5	-1.7	0.3	0.6	-0.4	-0.7	-1.3	-0.1	-0.9	-0.7	-0.3
Commuting to job workplace: Cycle	1.9	2.4	8.5	1.1	-1.3	2.4	-2.9	-0.3	1.7	0.9	0.7	-1.1	1.8	-0.0	-1.5
Myopia	1.5	2.1	5.4	2.3	-2.3	0.3	-1.6	0.3	2.2	1.1	0.9	-1.2	1.2	0.4	-1.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.9	0.1	-0.1	-0.2	-0.6	0.8	0.7	0.9	0.8	0.8	0.6	0.5	0.1
Cholesterol lowering medication	0.6	0.9	2.7	0.2	-0.7	1.2	-0.8	-0.6	1.6	0.5	1.3	0.6	1.3	0.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-1.1	0.2	-0.5	0.8	0.3	-0.1	0.1	0.4	1.0	0.3	0.4	0.8
Pain experienced in last month	1.0	1.7	5.7	-1.2	2.4	-1.5	2.1	0.8	-1.2	-0.0	0.5	1.1	-1.1	0.4	1.3
Supplements: Calcium	1.0	1.1	3.5	0.9	-1.4	0.3	-1.4	-1.9	0.2	-0.7	1.0	-0.4	0.6	-0.9	-1.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-1.1	0.4	-1.3	0.3	0.1	-1.1	-0.4	-0.3	-0.0	-1.3	-0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-0.4	0.7	-0.3	0.6	1.1	-0.9	1.1	0.8	0.1	0.2	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.3	-0.6	-0.4	-0.8	0.7	0.2	0.7	1.0	-0.8	0.4	-0.6	0.2
Heart disease (siblings)	0.3	0.4	1.7	-0.8	0.2	-0.3	-0.7	0.6	0.1	0.0	-1.0	-1.3	0.4	0.4	-0.4
Alcohol drinker status: Previous	3.9	4.4	11.2	-2.2	2.5	-1.0	2.3	2.1	-1.9	2.2	1.3	1.0	-0.3	2.9	3.4
Pack years of smoking	2.9	4.2	15.9	-1.3	-0.4	-2.0	-1.4	-0.7	-1.7	-1.7	-1.2	-3.5	-1.3	-4.0	-2.3
Impedance of whole body	0.8	4.1	10.6	-2.4	2.7	-0.9	2.1	2.2	-1.4	1.8	1.0	2.7	0.3	1.0	3.3
Leg fat mass (left)	1.8	7.2	15.7	-0.3	-0.9	-2.3	-0.2	-2.5	-2.1	-4.0	-3.2	-3.3	-3.6	-3.3	-2.9
Arm predicted mass (left)	0.1	0.6	1.4	0.9	-0.7	-0.8	-0.9	-1.0	0.8	-0.9	-0.0	-0.4	0.0	-0.9	-1.2