Hub : Genes

SEMA6D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.286	0.0980	5.3e-03	0.029	NA	-0.009	NA	0.034	5.0e-02	NA	7.0e-01	NA	3.8e-02
2	GTEx	Cells Transformed fibroblasts	0.229	0.0540	1.2e-09	0.102	NA	0.150	NA	0.149	4.7e-08	NA	2.4e-11	NA	2.8e-11
3	GTEx	Nerve Tibial	0.141	0.0487	1.9e-03	0.011	NA	0.007	NA	0.017	5.4e-02	NA	1.0e-01	NA	2.0e-02
4	GTEx	Ovary	0.702	0.1630	2.3e-03	0.035	NA	0.021	NA	0.098	4.8e-02	NA	9.7e-02	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	2.7	0.4	1.6	1.4	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.6	4.3	-0.4	1.3	-0.3	2.1
Depressed Affect (Nagel 2018)	1.3	2.7	6.1	1.4	1.2	-2.5	1.1
Depression (Nagel 2018)	0.9	1.4	2.9	1.3	0.7	-1.7	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.2	0.2	-1.5	-1.0	0.2
Neuroticism (Nagel 2018)	0.6	1.3	3.3	0.3	1.1	-1.8	0.8
Schizophrenia (2018)	1.8	3.8	12.0	-0.8	0.4	-1.5	3.5
Schizophrenia vs Biploar Disorder	0.8	1.1	2.2	-0.2	0.3	-1.5	1.4
Worry (Nagel 2018)	0.3	0.6	1.0	-0.5	0.7	-1.0	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	-0.1	-1.3	0.4	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	1.4	-1.2	0.2	-0.0	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.7	-0.7	-0.3	-0.9
Crohns Disease (2017)	0.9	1.9	3.2	1.8	1.3	-1.6	-0.6
Irritable Bowel Disease (IBD)	0.9	2.2	5.9	1.1	1.2	-2.4	0.4
Ulcerative Colitis (UC)	1.4	2.6	6.6	-0.3	0.9	-2.6	1.7
Major Depression (MDD)	2.6	3.2	9.6	0.2	3.1	-1.8	-0.0
Reaction Time	0.3	0.6	1.6	-1.2	0.6	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.3	0.2	-1.1	-0.9	0.3
Breast Cancer	2.3	5.6	13.0	1.8	-2.4	3.6	-0.4
Ovarian Cancer	1.3	1.7	2.8	1.5	0.8	1.7	1.1
Prostate Cancer	0.3	0.5	0.7	-0.8	-0.0	-0.8	-0.7
Age at First Birth	2.3	3.3	9.3	1.5	-3.0	0.7	-1.1
Bipolar Disorder (2011)	0.1	0.1	0.4	0.7	0.2	0.0	-0.0
Body Mass Index (BMI) (2010)	1.7	2.3	3.9	-1.9	-2.0	0.0	1.3
Coronary Artery Disease (CAD)	0.9	1.0	3.1	0.2	-1.8	0.7	0.7
Crohns Disease (2012)	0.8	1.3	3.6	1.9	-0.1	-0.2	-1.2
Mean Putamen Volume	2.7	3.1	5.2	-2.3	1.3	-1.7	1.6
Fasting Glucose	1.2	1.4	2.9	-0.1	-1.2	-1.2	-1.7
HbA1C	2.9	3.2	8.3	-2.1	0.4	0.2	-2.9
HDL Cholesterol	0.0	0.0	0.0	-0.1	0.0	0.1	0.2
LDL Cholesterol	1.0	1.6	5.0	-2.2	0.4	-1.0	0.1
Lupus	0.7	1.1	2.4	0.3	1.0	0.9	-1.6
Neuroticism (2016)	0.7	1.0	2.5	1.0	1.6	0.1	-0.6
Primary Biliary Cirrhosis	1.0	1.4	3.6	-0.9	-1.0	0.2	1.9
Rheumatoid Arthritis	2.8	3.9	7.1	-2.1	2.7	-1.0	-1.7
Schizophrenia (2014)	1.9	4.1	11.9	-0.5	0.3	-2.1	3.5
Triglycerides	0.5	0.8	1.8	-1.4	-0.3	-1.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	0.4	-0.6	0.6	0.6
Ulcerative Colitis	0.7	1.0	1.9	0.3	0.4	-1.3	1.4
Blood Eosinophil Count	0.2	1.6	3.6	-0.4	1.9	-1.3	1.0
Blood Platelet Count	0.5	5.3	7.7	2.8	2.7	1.8	1.8
Blood Red Count	0.1	0.5	1.3	0.9	-1.1	0.1	0.2
Blood White Count	0.7	5.4	19.5	-0.2	4.4	-1.3	0.5
Heel T-Score	0.7	5.5	8.5	-2.9	-2.4	-1.6	2.3
BMI	1.3	7.6	19.0	-0.3	-2.8	-1.8	4.4
Height	0.1	1.0	2.4	-0.1	-0.6	-1.1	-1.6
Waist Hip Ratio (WHR)	1.9	8.3	24.8	1.0	5.0	-2.6	-0.8
Systolic Blood Pressure	0.6	2.9	7.3	1.0	2.7	1.7	-0.7
Smoking Status	5.5	13.2	51.3	0.3	7.2	-1.2	0.4
Allergy or Eczema	0.5	1.2	1.9	0.8	-1.4	1.1	-1.1
Cardiovascular Disease	0.2	0.6	1.2	0.1	1.0	-0.6	1.1
Hypothyroidism (self reported)	0.4	1.0	2.2	1.5	0.8	-0.1	1.0
Respiratory disease	0.6	1.3	3.8	1.9	0.8	-0.8	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	-0.3	-1.1	-0.1	1.1
Lung FEV1/FVC ratio	0.3	1.3	2.7	-0.8	1.1	-0.8	1.6
Lung FVC	0.2	0.8	1.4	1.0	0.9	-1.2	-0.3
Neuroticism	1.1	2.7	7.0	-0.1	1.8	-2.6	-0.6
Chronotype (morning person)	1.1	2.6	4.1	-1.2	-2.0	-2.0	0.9
Hair Pigment	0.0	0.3	0.5	0.7	0.3	-0.7	-0.2
Tanning	0.1	1.7	6.8	0.1	2.6	-0.2	0.2
Hand grip strength (left)	1.0	2.6	4.8	0.7	2.2	-2.2	0.6
Number of treatments/medications taken	0.7	1.2	4.0	2.0	0.0	-0.6	0.6
Average weekly spirits intake	1.1	1.4	2.9	1.7	-0.2	-1.6	-0.4
Sensitivity / hurt feelings	0.8	1.3	3.9	-0.6	2.0	-1.0	0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.6	0.5	1.0	-1.9	-0.8
Hearing difficulty/problems: Yes	1.1	1.7	2.8	1.4	-1.7	-0.9	1.1
Relative age of first facial hair	0.6	1.3	2.2	0.7	1.3	1.5	-0.9
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.4	2.3	-0.7	0.4	-1.2
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.9	-1.2	1.2	1.7	-0.7
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	0.7	-0.9	0.7	0.6
Systolic blood pressure, automated reading	0.4	1.3	2.8	0.9	1.7	0.3	1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.1	0.7	0.0	-0.4
Angina	0.6	0.8	1.2	0.8	-0.9	-1.1	0.6
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.9	0.6	-0.2	-0.1
Vitamin and mineral supplements	0.4	0.6	1.5	-0.4	0.5	0.7	-1.2
Supplements: Zinc	0.9	1.0	3.4	-0.6	-1.8	0.1	0.5
Medication: Co-codamol	1.7	1.9	5.2	2.3	-0.8	-0.5	-1.3
Medication: Metformin	0.5	0.7	1.4	0.1	-1.2	1.1	0.5
Diabetes (father)	0.6	0.8	1.4	-0.5	-0.7	-1.2	-1.0
Diabetes (mother)	0.4	0.5	1.0	-0.9	-0.1	-0.6	1.0
Severe depression (siblings)	1.1	1.2	2.4	-1.1	1.1	-1.6	-0.1
Pack years adult smoking proportion	3.2	4.9	18.2	0.7	4.3	0.9	-0.2
Impedance of leg (right)	1.2	5.7	18.7	-0.9	4.3	1.2	-1.4
Leg fat-free mass (left)	0.7	3.8	11.1	1.1	-3.3	-1.2	1.2
Trunk fat percentage	1.9	7.7	13.6	1.9	-3.7	0.7	3.6
Hand grip strength (right)	0.8	2.1	4.8	1.5	2.2	-0.9	0.5
Townsend deprivation index at recruitment	0.6	0.9	2.0	-0.4	1.4	1.1	0.6
Current tobacco smoking	4.9	8.0	30.1	-1.0	5.5	-0.8	-0.2
Average weekly fortified wine intake	1.9	2.2	5.7	-1.2	-1.3	0.2	-2.4
Maternal smoking around birth	0.9	1.4	2.8	-0.2	1.7	0.2	1.6
Fed-up feelings	1.0	1.8	3.7	0.0	1.5	-1.1	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.4	1.0	1.8	-1.2	0.5
Relative age voice broke	0.5	0.7	1.4	0.6	-0.1	1.2	-1.0
Taking other prescription medications	1.2	1.8	5.7	2.4	-0.4	-1.0	0.8
Age when periods started (menarche)	0.2	0.5	1.5	-0.1	1.2	0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.4	-1.6	0.0	0.7	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.2	-1.4	-0.5	-2.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.2	0.2	-0.6	0.2
Qualifications: CSEs or equivalent	1.1	1.5	4.6	-0.5	1.1	2.1	0.1
Serious illness, injury or assault to yourself	0.6	0.7	2.4	-0.4	1.6	-0.4	-0.4
High blood pressure	0.1	0.3	1.0	0.1	0.1	0.3	1.0
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.8	0.8	-1.6	1.9	-1.3
Multivitamins +/- minerals	0.3	0.3	0.8	0.2	0.0	-0.8	0.9
Stomach or abdominal pain in last month	0.5	0.7	1.3	-0.7	-0.4	1.2	-0.8
Supplements: Glucosamine	0.7	0.9	2.9	-0.6	-1.7	0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.5	0.5	-0.9	1.3	-2.1
Medication: Atenolol	0.4	0.5	1.5	-0.5	0.4	-1.2	-0.3
Medication: Levothyroxine sodium	0.5	0.8	2.1	0.0	1.4	-0.2	1.0
Sitting height	0.2	1.6	4.5	0.6	-2.1	-1.0	0.8
Chronic bronchitis/emphysema (father)	0.9	1.1	1.7	0.8	1.2	-0.7	1.3
High blood pressure (mother)	1.6	2.3	4.6	1.2	-2.2	1.2	1.3
Body mass index (BMI)	1.6	7.0	14.4	1.3	-3.3	-1.0	3.8
Impedance of leg (left)	1.1	5.4	20.0	-1.0	4.5	0.6	-0.6
Leg predicted mass (left)	0.7	3.8	10.8	1.2	-3.3	-1.3	1.2
Trunk fat mass	1.7	7.2	14.7	1.7	-3.8	-0.2	3.3
Waist circumference	1.1	3.9	8.5	1.4	-1.5	-1.7	2.9
Number of incorrect matches in round	0.4	0.7	1.7	-0.4	-1.3	-0.3	0.8
Past tobacco smoking	1.4	2.5	6.1	-1.5	-2.5	0.3	-1.2
Alcohol usually taken with meals	2.9	4.6	10.7	0.1	-3.3	-2.1	-1.8
Nervous feelings	0.2	0.4	0.9	-0.9	0.5	0.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.7	-0.1	1.2	-2.2	-0.2
Hearing difficulty/problems with background noise	0.5	0.7	1.8	0.1	-1.3	-0.5	1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.2	0.4	-0.8	0.0
Had menopause	0.4	0.5	2.1	-1.4	0.1	0.1	0.1
Had other major operations	0.2	0.3	0.4	0.6	0.5	0.5	-0.5
Forced vital capacity (FVC)	0.4	1.6	3.4	0.9	1.2	-1.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	6.8	-1.8	-0.3	-2.6	1.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	-0.9	0.8	0.2	-0.9
Qualifications: None of the above	2.1	4.5	17.1	0.2	4.1	0.6	0.8
Financial difficulties in last 2 years	0.9	1.2	2.7	-0.1	1.3	-1.6	0.8
Mouth/teeth dental problems	0.8	1.3	2.9	-0.4	-0.0	-1.7	1.4
Heart attack	2.7	3.4	5.4	2.3	-0.6	-1.7	2.3
Allergy	0.6	1.4	3.3	-1.8	0.7	-0.9	1.0
Pain all over the body in last month	2.4	2.5	7.4	-0.1	1.6	-0.1	-2.7
Diabetes (self-reported)	0.0	0.1	0.2	0.1	0.5	-0.1	-0.0
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	14.4	1.8	-1.6	3.8	-0.9
Medication: Ramipril	0.7	0.9	3.4	-0.1	0.1	0.3	1.8
Medication: Simvastatin	0.7	1.0	2.2	1.5	-1.3	-0.0	-0.4
Fluid intelligence score	0.7	1.5	3.2	-1.0	-1.8	-0.3	-1.3
Illnesses of siblings	2.5	3.6	6.8	-2.6	1.9	-1.1	-1.6
Neuroticism score	0.9	1.8	3.8	-0.9	1.5	-1.9	-0.5
Weight	1.1	5.2	9.1	1.1	-3.0	-1.4	2.9
Impedance of arm (right)	0.6	2.9	10.8	0.6	-0.3	3.3	-0.7
Arm fat percentage (right)	2.4	9.5	19.3	1.8	-4.4	0.4	4.0
Trunk fat-free mass	0.6	3.2	11.3	-0.5	-1.1	-3.4	0.1
Hip circumference	1.7	7.2	14.4	1.9	-3.8	0.1	3.3
Time employed in main current job	1.9	2.2	3.7	-1.5	1.7	-1.9	0.1
Alcohol intake versus 10 years previously	0.8	1.1	2.0	1.4	1.3	0.9	-0.3
Father’s age at death	1.6	2.2	7.0	0.4	-2.6	-0.4	-1.2
Worrier / anxious feelings	0.2	0.4	1.5	0.0	-0.3	-1.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.0	0.6	-0.3	-2.0	1.4
Falls in the last year	0.1	0.2	0.6	0.2	0.2	0.8	-0.1
Hair/balding pattern: Pattern 3	1.1	1.7	3.4	1.8	-1.0	1.4	-0.3
Number of live births	0.3	0.4	0.8	0.6	-0.9	0.4	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	3.7	0.4	0.9	-1.9	-0.1
Pulse rate	0.9	1.5	3.9	-0.8	1.2	0.4	-2.0
Happiness	0.1	0.1	0.3	0.0	0.6	-0.3	0.1
Noisy workplace	0.8	0.9	3.2	-0.5	0.1	-1.8	0.5
Qualifications: A levels/AS levels or equivalent	1.7	3.9	13.2	0.6	-3.6	-0.1	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	5.5	0.8	-2.4	0.4	-1.6
Mouth/teeth dental problems: Dentures	0.9	1.5	3.9	1.1	1.0	-0.1	-2.0
Asthma	0.8	1.5	4.6	2.1	0.1	-0.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.6	-0.3	-0.6	0.0	-1.9
Medication: Cholesterol lowering	1.2	1.9	2.6	1.6	-1.6	-1.2	1.0
Depression (self-reported)	0.3	0.4	1.3	-1.1	0.4	-0.0	-0.4
Medication: Lansoprazole	1.5	1.8	3.8	1.2	0.6	1.9	-1.1
Prospective memory result	1.7	2.1	4.5	-0.9	2.1	-0.9	1.5
Lung cancer (father)	2.1	2.4	6.5	0.8	1.6	2.6	0.3
Illnesses of mother	1.5	1.8	5.6	-1.1	2.4	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.0	0.7	0.9	-2.0	-0.4
Pulse wave Arterial Stiffness index	1.7	2.0	4.3	-1.3	1.0	-1.0	-2.1
Impedance of arm (left)	0.9	4.3	15.9	0.6	-0.7	4.0	-0.6
Arm fat mass (right)	2.0	8.2	16.0	1.7	-4.0	-0.3	3.7
Trunk predicted mass	0.6	3.2	10.9	-0.5	-1.3	-3.3	0.2
Standing height	0.1	1.1	2.2	-0.4	0.3	-1.4	-1.5
Length of working week for main job	0.7	0.7	1.6	-1.3	1.1	0.1	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.1	0.2	-0.4	0.5
Breastfed as a baby	2.5	3.2	5.7	1.6	-2.4	-1.0	1.8
Tense / ‘highly strung’	1.8	3.0	5.8	-2.4	1.7	-1.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.1	0.8	0.1	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.5	-0.8	-1.2	0.8
Birth weight of first child	1.8	3.3	10.4	-0.4	-3.2	1.4	1.0
Peak expiratory flow (PEF)	0.3	0.8	3.0	-0.2	-1.7	-0.1	0.2
Pulse wave reflection index	0.2	0.3	0.7	-0.2	0.8	-0.4	-0.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.9	1.4	1.2	-0.5	-0.4
Loud music exposure frequency	1.0	1.0	2.3	-0.4	1.1	0.7	1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.0	-0.8	-2.0	-0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.2	1.1	-1.2	1.8	1.0
Blood clot in the leg (DVT)	1.3	1.6	2.7	1.3	0.6	-1.3	-1.7
Medication: Paracetamol	0.3	0.5	1.8	-0.2	-0.2	1.3	0.0
Headache pain in last month	1.0	1.7	5.1	0.6	1.1	-2.3	-0.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.9	-2.0	1.1	0.8	-1.0
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	0.4	-0.2	-0.1
Gout (self-reported)	0.4	0.5	1.1	-1.0	-0.6	-0.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	0.3	1.3	0.4	0.4
Medication: Amlodipine	0.6	0.8	1.1	0.9	1.0	-1.0	0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.0	1.3	0.6	-1.4	0.6
Birth weight	1.0	2.1	6.3	-1.3	-2.5	-0.6	-0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.1	0.1	1.4	-0.4	0.3
High blood pressure (siblings)	1.4	2.0	7.0	0.6	-2.7	0.3	0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	3.9	1.1	1.1	-2.0	-1.0
Body fat percentage	1.8	7.3	14.7	1.8	-3.3	0.4	3.8
Leg fat percentage (right)	1.0	3.6	9.6	1.3	-1.8	-0.4	3.1
Arm fat-free mass (right)	0.4	2.0	6.8	-0.2	-0.9	-2.6	0.5
Exposure to tobacco smoke outside home	0.6	0.9	2.4	0.9	1.5	-0.1	0.4
Comparative body size at age 10	1.3	3.7	9.9	-0.6	-3.2	1.9	0.8
Number of full brothers	1.5	1.8	2.9	1.7	1.4	0.4	1.5
Worry too long after embarrassment	0.1	0.2	0.2	-0.5	-0.3	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.1	0.7	1.0	1.5	-1.3
Wheeze or whistling in the chest in last year	0.8	1.3	2.1	0.9	1.2	-1.4	1.1
Number of children fathered	1.1	1.3	3.1	-0.7	1.0	-0.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	10.2	-0.3	-1.1	-1.3	3.2
Age at first live birth	1.0	1.7	5.3	0.3	-2.3	0.4	-1.1
Pulse wave peak to peak time	1.5	1.8	3.9	1.2	-1.0	0.9	2.0
Health satisfaction	0.4	0.5	1.4	1.2	0.3	0.6	0.2
Shortness of breath walking on level ground	1.7	2.1	4.8	-0.6	0.2	-1.8	2.2
Qualifications: College or University degree	2.6	8.2	27.1	0.2	-5.2	-2.2	-0.9
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.9	-0.4	0.1	1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	0.1	0.8	1.4	-0.3
Emphysema/chronic bronchitis	0.6	0.7	1.8	0.7	0.5	-1.4	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	2.3	-1.0	1.5	-1.3	0.9
Neck or shoulder pain in last month	0.3	0.4	0.9	0.4	-1.0	0.6	-0.1
Medication: Blood pressure	0.5	0.9	3.4	0.4	-0.1	-0.3	1.9
Angina (self-reported)	0.6	0.8	1.8	0.8	-0.6	-1.3	0.5
Migraine (self-reported)	0.6	0.8	2.0	-0.6	-0.9	0.3	-1.4
Medication: Ibuprofen	1.0	1.2	2.4	-1.6	0.2	-0.2	-1.5
Medication: Allopurinol	0.6	0.7	2.5	-0.6	-1.6	-0.1	0.3
Medication: Omeprazole	2.3	2.7	9.1	1.1	-3.0	-0.0	0.8
Medication: Seretide 50 evohaler	1.1	1.3	2.9	1.0	-1.7	0.8	-0.8
Mean time to correctly identify matches	0.4	0.7	1.4	-1.0	-0.0	-1.2	0.6
Heart disease (mother)	1.8	2.2	4.1	-0.2	-1.9	-1.0	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.6	1.2	1.3	-0.3	0.5
Whole body fat mass	1.8	7.6	14.6	1.6	-3.6	-0.4	3.8
Leg fat mass (right)	1.4	5.6	12.1	1.6	-2.7	-0.8	3.5
Arm predicted mass (right)	0.4	2.2	7.0	-0.1	-1.1	-2.6	0.8
Pulse rate, automated reading	0.5	1.6	4.8	0.6	0.1	1.0	-2.2
Alcohol intake frequency.	0.6	1.4	2.3	-0.8	1.5	0.9	-1.4
Comparative height size at age 10	0.1	0.8	2.5	0.7	-0.1	-1.6	-0.3
Number of full sisters	0.8	0.9	3.7	1.9	0.2	-0.0	-0.2
Suffer from ‘nerves’	0.4	0.6	1.7	0.1	0.1	0.9	-1.3
Overall health rating	0.9	2.0	4.4	2.1	1.1	-0.3	1.5
Chest pain or discomfort	0.6	0.9	1.5	1.2	-1.1	-0.8	-0.4
Had major operations	1.2	1.5	4.1	-0.6	-2.0	-1.1	-0.3
Age at last live birth	0.5	0.7	2.4	-0.3	-0.6	0.1	-1.6
Family relationship satisfaction	1.5	1.8	5.3	0.7	2.3	-1.1	0.3
Leg pain on walking	1.1	1.4	3.0	0.2	1.4	-1.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	3.2	-0.3	1.8	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.2	-0.1	1.3	1.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.2	-0.5	1.0	-0.6
Medication: Aspirin	0.8	1.1	2.4	1.5	-1.0	0.2	-1.0
Supplements: Vitamin C	0.8	0.9	2.7	-0.1	-1.6	0.8	-0.6
Knee pain experienced in last month	0.2	0.3	0.5	-0.7	-0.7	0.5	-0.1
Hypertension (Self-reported)	0.1	0.3	1.3	0.1	0.0	0.2	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.8	6.1	2.5	-1.7	2.2	-1.0
Illnesses of father: Heart disease	1.0	1.4	2.5	0.6	-1.6	-1.0	1.3
Illnesses of siblings: Diabetes	1.8	2.2	6.6	1.3	-0.5	-0.5	2.6
Smoking status: Previous	0.9	1.3	2.3	1.4	1.0	-0.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.8	-0.4	0.3	-1.7	0.4
Whole body fat-free mass	0.5	2.8	6.8	0.2	-2.0	-2.6	0.6
Leg fat-free mass (right)	0.7	3.9	10.6	1.0	-3.2	-1.6	1.3
Arm fat percentage (left)	2.6	10.3	21.8	1.8	-4.7	0.7	4.0
Average weekly red wine intake	1.3	1.9	7.3	0.5	-2.7	0.1	-0.1
Handedness (chirality/laterality): Left-handed	2.9	3.5	10.8	-0.7	3.3	-1.7	0.1
Mood swings	0.4	0.8	1.6	0.3	1.2	-1.2	0.2
Loneliness, isolation	1.9	2.6	7.0	0.0	2.6	-1.8	0.1
Long-standing illness, disability or infirmity	2.2	3.3	7.5	2.7	-1.5	-1.6	0.9
Ever had bowel cancer screening	2.1	2.4	3.9	1.8	-1.6	0.1	2.0
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.6	-0.8	-0.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.6	0.9	1.9	-0.3	0.2
Friendships satisfaction	0.6	0.8	2.6	0.4	0.5	-1.6	0.4
Qualifications: nursing, teaching	1.6	2.6	8.3	0.6	-2.9	-1.0	0.8
Commuting to job workplace: Walk	0.7	0.8	1.4	0.5	-1.0	-0.7	1.2
Eye problems/disorders: Cataract	1.1	1.3	2.9	-1.7	-0.3	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	1.0	-0.2	-0.6	1.0	-0.9
Medication for cholesterol	0.1	0.2	0.7	0.1	-0.9	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	2.5	-1.6	-1.4	1.3	1.3
Back pain experienced in last month	1.8	2.6	6.8	2.6	1.6	0.5	-0.9
Mineral and other dietary supplements	0.2	0.3	0.9	-0.1	0.7	-0.9	-0.1
Breast cancer (self-reported)	1.0	1.2	3.0	-0.8	1.7	1.0	-0.0
Asthma (self-reported)	0.7	1.5	4.8	2.2	-0.1	-0.4	1.0
Osteoporosis (self-reported)	0.8	1.0	1.8	-0.7	1.0	0.9	-1.3
Osteoarthritis (self-reported)	2.1	2.7	6.4	0.1	-2.1	2.5	-0.0
Medication: Aspirin	0.7	0.9	2.4	1.5	-0.7	0.3	-0.8
Medication: Gliclazide	0.8	0.9	1.9	1.4	-0.1	1.3	0.2
Illnesses of father: None of the above (group 1)	0.6	0.8	2.2	-0.1	0.9	1.5	0.1
Smoking status: Current	4.7	7.4	28.6	-0.6	5.3	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.8	-0.9	1.5	-2.6	0.1
Whole body water mass	0.5	2.8	7.0	0.1	-2.0	-2.6	0.5
Leg predicted mass (right)	0.7	3.9	10.7	1.0	-3.3	-1.5	1.2
Arm fat mass (left)	2.0	8.1	15.9	1.6	-4.0	-0.5	3.7
Number of self-reported non-cancer illnesses	1.1	1.8	5.2	2.3	-0.8	1.2	0.1
Average weekly champagne plus white wine intake	1.3	1.8	3.3	-1.8	0.3	-1.3	-1.5
Miserableness	1.3	2.2	5.6	1.8	0.2	-2.4	0.5
Guilty feelings	1.0	1.6	4.2	-2.1	1.2	0.1	-0.8
Wears glasses or contact lenses	0.7	0.8	2.6	-0.3	-1.6	-0.6	0.6
Ever taken oral contraceptive pill	1.5	1.6	6.0	0.0	2.4	-0.7	0.2
Hearing aid user	1.2	1.4	4.2	0.3	-0.7	-0.8	-2.1
Mother’s age at death	2.0	2.6	6.5	-0.4	-2.6	1.4	-1.3
Financial situation satisfaction	0.6	0.8	2.2	1.5	0.8	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	2.1	2.4	4.5	1.2	-2.1	1.9	0.4
Commuting to job workplace: Public transport	0.4	0.5	1.4	-0.3	-1.2	-0.2	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	1.0	-0.9	0.2	-0.3
Medication: Blood pressure	0.2	0.4	0.6	0.7	-0.3	0.7	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.1	0.7	-0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.3	-0.0	-1.5	0.7	0.2
High cholesterol (Self-reported)	1.1	2.0	3.4	0.5	-1.2	-1.7	1.8
Medication: Bendroflumethiazide	1.3	2.0	7.1	0.8	-0.2	0.6	2.7
Medication: Paracetamol	0.4	0.7	2.0	-0.8	-0.1	1.4	-0.1
Medication: Lisinopril	0.4	0.5	1.2	0.6	0.3	1.1	0.4
Medication: Atorvastatin	0.7	0.8	1.1	0.3	-1.0	-1.1	1.0
Illnesses of father: High blood pressure	1.3	1.6	3.9	1.3	-2.0	0.8	-0.4
Alcohol drinker status: Never	0.4	0.5	0.9	0.8	-0.1	0.6	-1.0
Ever smoked	1.0	1.8	5.2	0.8	2.3	-0.3	1.1
Basal metabolic rate	0.6	3.1	5.5	0.4	-2.3	-2.3	1.2
Leg fat percentage (left)	1.1	4.1	12.0	1.1	-1.6	-0.8	3.5
Arm fat-free mass (left)	0.6	3.2	10.2	0.1	-1.2	-3.2	1.1
Number of operations (self-reported)	0.7	1.0	3.5	0.6	-1.9	0.3	-0.3
Average weekly beer plus cider intake	1.7	2.4	7.3	0.1	2.7	1.3	0.9
Irritability	0.9	1.6	4.0	-0.7	-1.4	-2.0	-0.0
Risk taking	1.6	2.4	4.6	2.1	1.8	-0.3	1.3
Ever had prostate specific antigen (PSA) test	2.0	2.3	8.9	0.3	-3.0	0.5	0.1
Fractured/broken bones in last 5 years	1.9	2.5	5.1	0.3	2.3	1.8	-1.2
Age started oral contraceptive pill	0.8	1.0	3.5	0.5	-1.9	-0.4	-0.1
Diastolic blood pressure, automated reading	0.3	0.9	1.8	0.3	1.4	1.0	0.9
Ever depressed for a whole week	0.8	1.0	2.5	-1.0	0.4	0.5	-1.6
Unable to work because of sickness or disability	1.4	1.8	3.7	1.3	1.9	-0.4	-1.3
Commuting to job workplace: Cycle	0.5	0.5	1.8	1.3	-0.3	-0.5	-0.2
Myopia	1.5	2.2	7.7	0.3	-2.8	0.4	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.3	-0.4	-0.7	-0.0	-1.5
Cholesterol lowering medication	0.1	0.2	0.3	0.5	0.4	-0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	8.0	0.9	-2.8	0.4	-0.4
Pain experienced in last month	0.5	0.8	1.9	-1.1	-0.6	-0.2	1.4
Supplements: Calcium	1.6	1.8	3.1	-1.7	1.8	0.9	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	1.1	-0.6	0.7	-0.4
Heart attack/myocardial infarction (self-reported)	3.0	3.8	6.0	2.5	-0.5	-2.0	2.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.8	1.2	0.7	-1.0	-1.7
Heart disease (siblings)	2.4	2.9	7.8	2.8	-0.1	1.9	0.3
Alcohol drinker status: Previous	0.6	0.6	1.7	-0.9	1.3	-0.2	-0.1
Pack years of smoking	2.8	4.1	14.3	0.8	3.8	1.0	-0.7
Impedance of whole body	0.6	3.0	7.3	-0.1	2.1	2.7	-0.4
Leg fat mass (left)	1.5	5.8	13.1	1.4	-2.6	-1.1	3.6
Arm predicted mass (left)	0.6	3.2	9.8	0.1	-1.1	-3.1	1.3