Hub : Genes

SERPINA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.1344	0.0222	1.4e-15	0.066	0.056	0.098	0.096	0.086	2.1e-20	1.3e-17	5.1e-30	2.1e-29	2.5e-26
2	YFS	Blood	0.5410	0.0307	0.0e+00	0.235	0.413	0.450	0.428	0.431	1.4e-75	4.3e-148	3.1e-166	1.5e-155	1.2e-156
3	TCGA	Breast Invasive Carcinoma	0.0198	0.0097	1.4e-03	0.009	0.013	0.008	NA	0.012	4.1e-03	9.8e-04	5.9e-03	NA	1.3e-03
4	TCGA	Colon Adenocarcinoma	0.1240	0.0670	2.2e-03	0.052	0.049	0.081	NA	0.096	5.5e-04	8.5e-04	2.0e-05	NA	3.5e-06
5	TCGA	Prostate Adenocarcinoma	0.0734	0.0349	2.4e-03	0.010	0.027	0.030	NA	0.009	3.1e-02	7.9e-04	3.7e-04	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	5.1	-0.1	2.0	-2.2	0.9	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	0.9	1.2	0.2	-0.0	0.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	-0.7	-0.5	1.2	0.0	0.6
Depression (Nagel 2018)	1.2	1.9	4.9	-1.5	-0.3	-1.2	2.2	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	2.7	1.7	1.3	1.6	-0.9	1.1
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.7	0.6	0.2	0.1
Schizophrenia (2018)	0.7	1.4	4.3	1.3	-0.0	2.1	-0.7	0.6
Schizophrenia vs Biploar Disorder	2.2	2.9	6.3	1.8	-1.1	2.5	-1.3	1.3
Worry (Nagel 2018)	0.2	0.5	1.1	0.1	-1.0	1.1	-0.4	0.3
Alzheimer’s Disease (in mother)	0.6	0.7	3.3	-0.4	-0.1	-1.8	0.2	-0.3
Alzheimer’s Disease (in father)	1.5	1.6	5.1	-1.6	0.5	-0.2	2.3	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.8	-0.5	-0.9	0.2	-0.4
Crohns Disease (2017)	0.5	1.1	4.1	-0.1	0.1	-1.0	0.8	-2.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.0	-0.1	0.4	0.5	-0.6
Ulcerative Colitis (UC)	0.2	0.3	1.5	-0.3	-0.3	1.2	0.1	0.2
Major Depression (MDD)	0.5	0.6	2.3	-0.6	0.6	-0.1	1.5	-0.2
Reaction Time	0.3	0.5	1.8	-0.2	0.4	-0.7	0.4	-1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.1	1.8	0.5	1.1	-0.4	1.1
Breast Cancer	0.5	1.1	2.4	1.6	0.6	0.9	-1.4	0.4
Ovarian Cancer	0.4	0.5	1.1	1.1	-0.3	0.4	-1.0	0.1
Prostate Cancer	1.8	2.5	6.1	-1.9	-2.5	-0.4	1.5	-0.8
Age at First Birth	0.8	1.2	3.1	1.0	0.5	1.8	-0.8	1.0
Bipolar Disorder (2011)	1.2	1.2	2.9	-0.9	-0.0	-1.7	0.8	-1.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	1.3	0.9	0.5	-0.6	1.0
Coronary Artery Disease (CAD)	0.8	0.9	2.2	0.8	0.8	1.0	1.5	0.4
Crohns Disease (2012)	0.3	0.4	0.9	0.4	0.9	-0.4	0.2	-0.9
Mean Putamen Volume	0.5	0.6	1.3	0.9	-1.1	0.9	-0.3	0.0
Fasting Glucose	0.2	0.2	0.8	-0.5	-0.9	-0.1	0.3	0.2
HbA1C	0.3	0.3	0.6	0.5	0.7	0.2	0.0	0.8
HDL Cholesterol	0.7	1.2	1.5	-1.2	-0.9	-1.0	1.0	-1.2
LDL Cholesterol	0.5	0.8	3.0	0.5	-0.2	-0.7	-0.1	-1.7
Lupus	1.4	2.1	5.1	0.9	2.3	0.5	-1.0	1.9
Neuroticism (2016)	0.7	1.0	2.0	-0.6	-1.4	0.9	-0.9	0.9
Primary Biliary Cirrhosis	0.9	1.3	2.1	0.8	1.0	1.4	-0.9	1.4
Rheumatoid Arthritis	0.5	0.7	1.5	0.4	0.9	0.8	-0.6	1.2
Schizophrenia (2014)	0.3	0.7	1.7	1.3	0.3	1.0	-0.8	-0.1
Triglycerides	0.5	0.9	3.6	-0.2	1.9	-0.5	-0.6	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.5	-0.5	-0.1	-0.6	1.6	0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.2	0.1	0.6	-0.5	0.5
Blood Eosinophil Count	0.5	3.8	8.6	-2.0	1.7	-2.9	0.9	-1.7
Blood Platelet Count	1.2	14.5	31.6	-4.0	3.7	-5.6	1.0	-3.1
Blood Red Count	0.1	1.0	2.8	1.0	0.1	1.0	-1.7	-0.2
Blood White Count	0.4	2.9	9.8	-0.6	3.1	-1.6	-1.4	-0.1
Heel T-Score	0.2	1.4	4.9	0.6	0.3	1.0	-0.7	2.2
BMI	0.5	3.2	8.0	-2.8	-0.7	-1.7	1.0	-1.8
Height	0.6	12.4	32.5	2.6	2.3	-4.1	-1.0	-5.7
Waist Hip Ratio (WHR)	0.4	1.7	3.3	-1.6	-1.8	-1.4	-0.1	-0.9
Systolic Blood Pressure	0.5	2.3	8.2	-1.6	-2.9	0.5	-0.5	-0.4
Smoking Status	0.1	0.2	0.4	-0.2	-0.7	0.6	0.4	0.1
Allergy or Eczema	0.2	0.5	0.9	0.6	-0.0	0.9	-0.9	0.6
Cardiovascular Disease	0.1	0.3	0.9	-1.0	-0.2	0.1	0.2	-0.5
Hypothyroidism (self reported)	1.1	2.4	5.9	1.1	-0.9	1.8	-2.4	1.1
Respiratory disease	0.1	0.2	0.9	0.2	-0.1	0.2	-1.0	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.1	-1.1	0.7	0.6	-0.1
Lung FEV1/FVC ratio	0.9	4.4	8.5	-1.7	-0.7	-2.5	2.0	-2.9
Lung FVC	0.8	4.3	10.8	3.3	1.3	0.6	-2.9	-0.4
Neuroticism	1.2	2.9	6.9	1.5	-0.1	2.6	-1.8	1.5
Chronotype (morning person)	0.6	1.4	2.9	-1.7	-0.9	-1.6	0.5	-0.7
Hair Pigment	0.0	0.4	1.3	0.7	0.2	-0.6	-1.1	0.1
Tanning	0.2	2.1	5.1	-1.2	-2.2	0.1	2.0	0.4
Hand grip strength (left)	0.7	1.8	3.8	-0.5	1.5	-1.9	1.4	-0.8
Number of treatments/medications taken	0.5	0.8	2.4	-1.5	-0.7	-0.5	0.7	-0.8
Average weekly spirits intake	1.3	1.7	5.1	-0.5	-2.3	0.4	1.1	-1.3
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.1	0.9	-0.1	0.5	0.9
Frequency of depressed mood in last 2 weeks	2.4	3.4	7.8	-2.4	-0.1	-1.8	2.8	-0.1
Hearing difficulty/problems: Yes	0.5	0.7	2.8	0.8	1.7	-0.1	0.1	0.4
Relative age of first facial hair	0.8	1.6	5.3	2.3	1.3	0.6	-0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.9	-0.5	1.4	-1.3	0.8	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.6	-0.7	0.4	0.6	0.5
Ever had hysterectomy (womb removed)	1.1	1.2	2.9	0.9	-0.2	1.4	-1.7	0.7
Systolic blood pressure, automated reading	1.1	3.1	7.9	-2.7	-2.8	-0.6	-0.5	-0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	1.1	-0.7	0.1	-0.7	0.5
Angina	1.2	1.6	5.5	-1.0	-2.3	1.1	0.1	-0.7
Medication for hormone replacement therapy	1.0	1.2	2.6	1.2	0.3	1.6	0.2	1.2
Vitamin and mineral supplements	0.2	0.3	0.9	-0.3	0.4	-0.3	0.9	-0.2
Supplements: Zinc	0.9	1.0	2.8	-0.9	-0.0	-1.1	-0.3	-1.7
Medication: Co-codamol	0.6	0.7	1.9	0.5	-1.0	0.8	0.1	1.4
Medication: Metformin	0.3	0.4	0.5	-0.4	-0.7	-0.6	0.7	-0.5
Diabetes (father)	1.8	2.3	8.3	0.9	0.6	1.3	-0.4	2.9
Diabetes (mother)	1.2	1.5	4.3	-1.1	-0.8	-1.0	2.1	-0.5
Severe depression (siblings)	1.5	1.7	3.4	0.9	-0.9	1.6	-1.8	1.1
Pack years adult smoking proportion	0.6	1.0	3.0	-1.7	0.1	-0.2	1.3	-0.4
Impedance of leg (right)	0.1	0.7	1.4	0.5	1.2	-0.2	-0.9	-0.9
Leg fat-free mass (left)	0.4	2.2	6.1	-0.1	1.6	-2.5	0.4	-1.4
Trunk fat percentage	0.6	2.4	4.4	-1.8	0.2	-2.1	0.8	-2.0
Hand grip strength (right)	0.4	1.2	3.4	0.3	1.8	-1.2	1.0	-0.4
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.9	1.3	-1.0	0.5	-0.3
Current tobacco smoking	0.5	0.9	3.2	0.5	-0.4	1.8	-0.2	0.9
Average weekly fortified wine intake	1.1	1.3	2.1	-0.9	-1.2	-1.5	-0.7	-1.3
Maternal smoking around birth	0.7	1.0	2.8	0.6	1.7	0.0	-0.3	1.3
Fed-up feelings	0.8	1.4	3.6	-1.9	-1.5	0.1	1.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.0	-1.1	0.5	-0.2	2.0	0.1
Relative age voice broke	0.1	0.1	0.3	0.6	0.2	-0.2	-0.1	-0.5
Taking other prescription medications	0.5	0.7	2.3	-0.3	-0.5	1.5	0.0	0.9
Age when periods started (menarche)	0.3	0.6	1.8	-0.8	0.0	-1.3	0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	0.1	-0.9	1.0	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	0.3	-0.4	0.2	-1.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	0.4	-0.5	-0.8	0.8	-0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.4	-1.1	-1.2	-0.8	0.4	-0.2
Serious illness, injury or assault to yourself	1.3	1.5	2.6	-1.3	0.4	-1.4	1.6	-1.0
High blood pressure	0.2	0.5	1.4	-1.2	-0.7	0.3	-0.2	-0.5
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	-0.1	0.5	-0.3	0.3	-0.2
Multivitamins +/- minerals	0.2	0.2	0.5	0.2	-0.5	0.1	-0.6	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.2	0.7	-0.7	0.2	-0.1
Supplements: Glucosamine	0.3	0.3	0.9	-0.3	-0.8	-0.2	-1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	0.7	1.3	0.5	-0.8	0.7
Medication: Atenolol	1.2	1.5	3.4	0.7	-1.0	1.9	-1.5	0.6
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.6	-0.0	0.5	-0.3	0.7
Sitting height	0.3	2.3	4.2	1.4	2.0	-1.4	-0.0	-1.9
Chronic bronchitis/emphysema (father)	1.4	1.6	4.4	1.2	0.5	1.4	-2.1	-0.2
High blood pressure (mother)	0.1	0.2	0.3	-0.5	-0.3	0.6	-0.3	-0.5
Body mass index (BMI)	0.9	3.7	9.5	-3.1	-0.9	-2.2	1.3	-1.2
Impedance of leg (left)	0.1	0.3	0.8	0.2	0.6	0.2	-0.2	-0.9
Leg predicted mass (left)	0.4	2.4	6.7	-0.1	1.7	-2.6	0.5	-1.5
Trunk fat mass	0.7	2.9	6.1	-1.7	0.6	-2.5	0.6	-2.1
Waist circumference	0.7	2.7	6.0	-2.3	-0.2	-2.4	0.7	-1.2
Number of incorrect matches in round	0.8	1.3	2.9	-1.4	-0.8	-0.8	1.7	-0.2
Past tobacco smoking	0.1	0.2	0.9	-0.3	1.0	-0.1	0.3	0.0
Alcohol usually taken with meals	0.8	1.3	4.4	2.1	0.7	0.9	-0.8	0.4
Nervous feelings	0.9	1.8	3.5	0.4	-1.7	1.2	-1.9	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.7	-0.6	-0.5	-0.8	1.6	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.9	-0.2	1.2	-0.4	0.2
Hair/balding pattern: Pattern 2	0.9	1.1	3.2	-1.8	-0.7	-0.6	0.6	1.1
Had menopause	1.1	1.3	4.0	-1.1	-2.0	0.8	0.9	0.1
Had other major operations	0.7	0.8	1.8	0.6	0.6	0.8	-1.3	1.0
Forced vital capacity (FVC)	0.9	3.6	8.4	2.9	2.4	-0.7	-1.6	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.0	0.1	0.1	-0.8	0.4
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	9.1	-2.0	0.9	-0.8	3.0	-1.1
Qualifications: None of the above	1.0	2.1	4.0	-2.0	-0.6	-1.4	1.4	-1.5
Financial difficulties in last 2 years	0.5	0.6	1.3	0.4	-0.9	1.1	-0.1	0.9
Mouth/teeth dental problems	0.6	0.9	2.1	0.7	0.3	0.9	-1.4	1.0
Heart attack	0.8	1.0	2.7	-0.3	-1.0	1.6	-0.9	0.7
Allergy	0.3	0.6	1.4	0.4	-0.6	1.2	-0.4	0.9
Pain all over the body in last month	0.2	0.3	0.6	0.5	-0.2	0.7	0.3	0.6
Diabetes (self-reported)	0.6	1.0	2.9	1.2	-0.6	1.7	0.0	0.2
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.2	-0.1	0.3	0.2	0.4	-0.0
Medication: Ramipril	0.9	1.1	3.1	-1.3	-1.8	0.8	-0.3	-0.2
Medication: Simvastatin	0.4	0.6	2.8	0.2	-0.3	-0.2	-1.7	-0.4
Fluid intelligence score	1.2	2.6	5.9	2.4	1.0	1.7	-1.2	1.2
Illnesses of siblings	0.8	1.1	2.9	1.7	1.3	-0.2	0.2	0.8
Neuroticism score	0.4	0.9	2.1	0.3	-0.4	1.4	-0.6	1.4
Weight	0.8	4.0	10.0	-1.7	1.0	-3.2	0.8	-2.4
Impedance of arm (right)	0.8	3.7	9.7	3.1	1.1	1.9	-1.9	0.4
Arm fat percentage (right)	0.3	1.2	2.6	-1.6	-0.6	-1.2	0.6	-1.1
Trunk fat-free mass	0.6	3.5	9.1	0.2	2.1	-3.0	0.3	-2.0
Hip circumference	0.6	2.8	6.3	-1.5	1.5	-2.5	0.7	-1.6
Time employed in main current job	0.8	0.9	2.3	0.5	-0.5	0.1	-1.5	-1.3
Alcohol intake versus 10 years previously	0.7	1.0	2.1	-0.8	0.9	-1.1	1.5	-0.4
Father’s age at death	0.4	0.5	1.2	0.1	1.1	-0.6	0.8	-0.4
Worrier / anxious feelings	0.5	1.0	2.2	0.7	0.3	1.2	-1.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-1.1	0.3	-0.7	0.9	-0.3
Falls in the last year	0.1	0.2	0.5	0.1	-0.1	0.6	-0.1	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.9	0.3	0.1	-0.8	0.2
Number of live births	0.2	0.3	0.6	0.7	0.1	0.6	-0.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.2	1.8	1.6	-1.3	-0.2	-1.3
Pulse rate	1.4	2.3	5.2	-1.8	0.9	-2.3	1.3	-0.9
Happiness	0.3	0.4	1.5	-0.4	0.0	-0.6	1.2	0.0
Noisy workplace	0.5	0.6	2.6	-0.3	-1.6	-0.2	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	1.3	2.9	8.1	1.9	0.7	1.5	-2.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.0	0.8	1.1	-0.3	1.0	1.4
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	-0.8	0.8	-1.4	1.4	-1.0
Asthma	0.0	0.1	0.3	-0.5	0.1	-0.2	-0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.3	0.2	0.1	-0.5	-0.0
Medication: Cholesterol lowering	0.3	0.4	1.5	0.4	-0.4	0.5	-1.2	-0.3
Depression (self-reported)	1.7	2.0	4.4	-1.0	-0.2	-1.4	2.1	-1.6
Medication: Lansoprazole	0.6	0.7	1.1	-0.4	-1.1	1.0	-0.6	1.1
Prospective memory result	0.8	0.9	2.4	-1.2	0.6	-1.5	0.7	0.1
Lung cancer (father)	0.4	0.5	1.1	0.6	0.3	1.0	-0.7	0.7
Illnesses of mother	0.9	1.1	4.3	2.1	0.5	1.0	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.7	1.4	2.2	-1.6	-0.1	-1.4
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	-0.9	0.3	-0.4	1.1	0.4
Impedance of arm (left)	0.7	3.3	8.2	2.9	1.5	1.8	-1.5	0.3
Arm fat mass (right)	0.7	2.9	6.1	-2.0	0.1	-2.5	1.0	-1.9
Trunk predicted mass	0.6	3.5	8.9	0.2	2.0	-3.0	0.3	-2.1
Standing height	0.8	8.3	19.4	2.8	4.4	-2.4	-1.4	-2.5
Length of working week for main job	0.9	1.0	1.8	-0.3	1.1	-1.2	0.6	-1.3
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.6	-0.7	-0.1	-0.6	0.7
Breastfed as a baby	1.2	1.4	3.4	1.4	1.9	0.6	-1.3	-0.1
Tense / ‘highly strung’	0.4	0.6	1.6	0.2	-0.2	1.0	0.5	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	7.0	-1.8	-0.9	-1.3	2.6	-1.1
Hair/balding pattern: Pattern 4	0.5	1.2	2.7	0.6	-1.6	1.5	-0.1	0.7
Birth weight of first child	0.5	0.8	1.7	1.1	1.3	-0.1	-0.4	1.0
Peak expiratory flow (PEF)	1.3	2.9	6.6	-0.4	1.9	-2.6	1.4	-1.6
Pulse wave reflection index	0.6	0.7	2.4	0.5	-0.2	0.7	1.6	0.6
Ever highly irritable/argumentative for 2 days	3.7	4.5	10.8	-3.3	-0.3	-1.9	2.4	-1.4
Loud music exposure frequency	0.5	0.5	2.0	-0.3	-0.8	-0.1	1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.0	1.7	0.6	0.5	-1.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.1	0.4	0.6	0.3	0.0
Blood clot in the leg (DVT)	0.6	0.8	3.0	-0.1	0.6	-0.7	0.5	-1.7
Medication: Paracetamol	0.4	0.6	1.4	-0.5	1.0	-1.2	-0.4	0.4
Headache pain in last month	0.3	0.5	1.3	-0.2	0.4	0.2	1.1	-1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.5	1.6	1.2	1.0	0.4	1.9
Glaucoma (self-reported)	0.6	0.7	2.3	0.5	-0.3	1.5	-0.1	0.8
Gout (self-reported)	0.3	0.5	1.0	0.5	-0.0	1.0	-0.9	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.0	-0.4	0.9	-0.3	0.7
Medication: Amlodipine	3.0	4.2	6.2	-2.5	-1.8	-2.1	1.0	-2.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	4.0	-0.9	0.6	-1.2	1.1	-2.0
Birth weight	0.3	0.6	1.2	-0.6	-0.4	-0.8	1.1	-0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	1.4	1.1	0.4	-0.8	0.7
High blood pressure (siblings)	2.2	3.2	8.2	-2.9	-1.5	-1.8	0.9	-1.2
Forced vital capacity (FVC), Best measure	1.0	3.6	9.4	2.3	3.1	-1.2	-0.9	-1.1
Body fat percentage	0.6	2.2	4.2	-2.1	-0.2	-1.9	0.7	-1.7
Leg fat percentage (right)	1.0	3.7	8.9	-3.0	-0.6	-2.2	1.0	-1.8
Arm fat-free mass (right)	0.9	4.4	11.1	-1.2	1.8	-3.3	1.3	-2.1
Exposure to tobacco smoke outside home	0.3	0.4	1.3	1.1	-0.2	-0.1	-0.7	-0.3
Comparative body size at age 10	0.0	0.1	0.3	-0.2	-0.6	-0.1	0.3	-0.3
Number of full brothers	0.2	0.2	0.6	0.5	0.3	-0.4	0.1	0.7
Worry too long after embarrassment	0.5	0.9	3.6	-0.4	0.2	0.8	0.2	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.4	-0.6	-0.5	0.2	2.1	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.8	-1.3	-0.1	-0.3	0.4	0.3
Number of children fathered	0.3	0.3	1.1	1.0	-0.3	0.1	-0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	0.2	1.1	-0.3	1.3	0.6
Age at first live birth	1.5	2.6	6.1	1.2	2.5	0.4	-2.1	1.0
Pulse wave peak to peak time	0.7	0.8	1.9	1.3	-0.1	0.4	-1.4	-0.6
Health satisfaction	0.4	0.5	1.8	-0.3	-0.1	-0.7	1.3	-0.5
Shortness of breath walking on level ground	1.6	1.9	4.5	-1.0	0.7	-1.6	2.1	-0.9
Qualifications: College or University degree	0.3	1.0	2.8	0.5	1.1	-0.5	-1.7	0.7
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.7	0.1	0.4	0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.0	0.4	-0.4	0.8	-0.7
Emphysema/chronic bronchitis	1.4	1.6	2.1	1.5	1.1	1.2	-1.3	1.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-0.6	-0.1	-0.5	1.0	-0.8
Neck or shoulder pain in last month	0.5	0.7	2.2	-0.8	-1.5	0.3	-0.0	-0.8
Medication: Blood pressure	0.9	1.5	2.8	-1.3	-1.7	-0.5	-0.8	-1.6
Angina (self-reported)	1.0	1.3	4.5	-0.8	-2.1	1.1	-0.0	-0.4
Migraine (self-reported)	0.9	1.1	4.8	0.5	2.2	-0.5	-0.5	0.2
Medication: Ibuprofen	0.3	0.3	0.8	0.5	0.6	-0.2	-0.9	-0.1
Medication: Allopurinol	1.2	1.5	3.3	1.7	0.4	1.1	-1.8	0.6
Medication: Omeprazole	0.2	0.2	1.1	-0.0	-0.1	0.1	-0.1	-1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-1.1	-0.6	-1.2	-0.1	-0.1
Mean time to correctly identify matches	0.5	1.0	3.6	-0.6	0.4	-0.8	0.2	-1.9
Heart disease (mother)	1.7	2.1	6.3	-2.5	-1.0	-1.7	-0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	5.9	-2.4	-0.9	-1.7	1.9	-2.4
Whole body fat mass	0.7	2.7	6.5	-1.8	0.5	-2.6	0.7	-1.8
Leg fat mass (right)	0.9	3.4	6.2	-2.5	-0.2	-2.5	0.8	-1.9
Arm predicted mass (right)	0.7	3.6	9.9	-1.2	1.4	-3.1	1.1	-1.9
Pulse rate, automated reading	0.3	0.9	2.4	-1.5	-0.3	-0.5	0.8	-1.1
Alcohol intake frequency.	0.9	2.2	6.5	-0.6	0.1	-2.0	0.3	-2.5
Comparative height size at age 10	0.7	3.8	8.6	2.9	2.8	0.7	-1.4	-0.1
Number of full sisters	1.0	1.2	3.1	-0.2	1.8	-0.3	0.9	1.4
Suffer from ‘nerves’	0.6	1.0	2.6	-1.4	-1.6	-0.0	0.6	-0.1
Overall health rating	0.2	0.5	0.9	-0.8	-0.5	0.3	0.9	-0.6
Chest pain or discomfort	0.1	0.2	0.4	-0.3	0.4	-0.6	0.1	-0.4
Had major operations	0.6	0.7	1.3	-1.1	-0.7	-0.5	0.3	-1.1
Age at last live birth	0.9	1.3	3.2	1.4	1.8	0.6	-0.9	0.5
Family relationship satisfaction	0.7	0.8	2.9	0.1	0.8	-0.8	1.7	-0.3
Leg pain on walking	0.7	0.9	3.7	-0.6	-0.1	0.1	1.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.2	-1.0	-2.1	0.6	2.0	0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.7	-0.8	0.1	-1.6	1.4	-1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.4	1.4	0.2	2.1	-0.9	0.4
Medication: Aspirin	1.0	1.3	3.5	0.1	-1.9	1.7	0.2	0.2
Supplements: Vitamin C	0.4	0.5	1.9	0.2	0.5	-0.2	-1.4	0.4
Knee pain experienced in last month	0.3	0.5	1.8	-0.4	-1.3	0.5	0.2	-0.6
Hypertension (Self-reported)	0.2	0.6	1.3	-1.0	-1.1	0.4	-0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.1	-1.4	1.4	-1.5	1.4	-0.6
Illnesses of father: Heart disease	2.6	3.6	7.3	-2.6	-2.7	-0.7	1.0	-1.5
Illnesses of siblings: Diabetes	0.8	1.0	1.7	-0.7	-1.0	1.3	1.2	0.2
Smoking status: Previous	0.2	0.3	1.0	-0.2	-1.0	-0.5	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	16.5	2.3	4.1	0.4	-0.1	1.2
Whole body fat-free mass	0.5	2.9	7.6	0.1	1.9	-2.8	0.5	-1.7
Leg fat-free mass (right)	0.4	2.1	5.5	-0.2	1.6	-2.3	0.9	-1.4
Arm fat percentage (left)	0.4	1.5	3.0	-1.7	-0.5	-1.4	0.8	-1.2
Average weekly red wine intake	0.4	0.5	1.2	1.0	0.3	0.5	-1.1	-0.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.4	-1.3	0.9	-1.8	1.5	-1.4
Mood swings	0.1	0.3	0.7	-0.9	-0.4	0.6	-0.1	0.3
Loneliness, isolation	1.1	1.5	3.8	0.3	-0.8	1.9	-0.3	1.7
Long-standing illness, disability or infirmity	1.0	1.6	4.0	-1.1	-0.5	-0.3	2.0	-1.6
Ever had bowel cancer screening	0.6	0.7	1.6	-0.3	-1.0	-0.8	-1.3	-0.3
Diabetes diagnosed by doctor	0.2	0.4	0.8	0.8	-0.1	0.9	0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	0.2	0.8	-0.2	-0.6	0.5
Friendships satisfaction	0.7	0.8	1.3	1.0	0.8	1.1	0.2	1.2
Qualifications: nursing, teaching	2.7	4.2	9.5	2.7	1.0	1.6	-3.1	0.5
Commuting to job workplace: Walk	0.7	0.7	1.4	0.4	0.2	1.2	-1.0	1.1
Eye problems/disorders: Cataract	0.5	0.5	1.3	-1.2	-0.0	-1.0	-0.3	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.0	-0.9	-1.0	-1.3	0.8	-1.4
Medication for cholesterol	0.7	1.1	2.0	1.2	0.8	0.3	-1.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.5	-1.0	-0.0	0.8	-0.8
Back pain experienced in last month	0.3	0.5	1.0	-0.7	0.8	-0.3	1.0	0.4
Mineral and other dietary supplements	0.2	0.2	0.5	-0.1	0.7	-0.7	0.4	0.1
Breast cancer (self-reported)	1.3	1.5	3.3	1.0	-0.1	1.4	-1.8	1.2
Asthma (self-reported)	0.1	0.1	0.3	-0.6	-0.1	-0.1	-0.1	-0.4
Osteoporosis (self-reported)	1.4	1.7	3.0	-1.2	1.4	-1.7	0.3	-1.5
Osteoarthritis (self-reported)	0.4	0.6	1.2	-1.1	-0.6	-1.0	-0.1	-0.4
Medication: Aspirin	1.0	1.3	3.9	-0.2	-2.0	1.4	0.6	-0.3
Medication: Gliclazide	0.4	0.5	1.4	0.3	-0.9	0.2	-0.1	1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	1.2	0.8	-0.2	-0.7	0.5
Smoking status: Current	0.5	0.9	2.9	0.7	-0.3	1.7	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.2	1.0	1.4	-0.9	0.4	-1.5
Whole body water mass	0.5	3.1	8.4	-0.1	1.9	-2.9	0.6	-1.8
Leg predicted mass (right)	0.4	2.1	5.2	-0.2	1.6	-2.3	0.9	-1.3
Arm fat mass (left)	0.7	2.8	5.7	-1.9	0.1	-2.4	1.0	-1.9
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	-1.2	0.9	-0.8	1.2	-0.6
Average weekly champagne plus white wine intake	1.0	1.3	2.1	0.8	1.2	0.9	-1.3	1.5
Miserableness	0.4	0.7	1.8	-1.3	0.3	-0.4	1.1	-0.4
Guilty feelings	0.5	0.8	2.0	-0.2	0.9	-0.6	1.4	0.7
Wears glasses or contact lenses	0.1	0.2	0.5	0.2	-0.7	0.4	-0.2	-0.1
Ever taken oral contraceptive pill	0.8	0.9	1.6	1.2	0.2	0.9	-0.7	1.2
Hearing aid user	0.8	0.9	2.2	0.2	1.5	-1.4	-0.5	-0.0
Mother’s age at death	0.1	0.1	0.2	0.5	0.1	-0.4	0.2	-0.0
Financial situation satisfaction	0.8	0.9	3.7	-0.1	-1.9	0.2	0.8	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.0	-0.2	-0.6	0.3	-0.8
Commuting to job workplace: Public transport	2.0	2.3	5.1	2.1	0.8	2.3	-0.8	1.0
Eye problems/disorders: Glaucoma	0.3	0.3	1.3	0.5	-0.1	1.2	0.2	0.1
Medication: Blood pressure	0.4	0.7	2.0	-1.4	-0.9	0.1	0.4	-0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.0	-0.7	-1.7	0.1	0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	0.5	-1.1	1.0	-1.1	-0.3
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.5	-0.5	-0.5	-0.9	-0.3
Medication: Bendroflumethiazide	0.4	0.6	1.8	1.4	0.0	1.1	-0.1	-0.4
Medication: Paracetamol	0.6	0.9	2.6	-0.7	0.7	-1.6	-0.9	-0.4
Medication: Lisinopril	0.4	0.5	1.4	1.2	0.3	0.7	-0.7	-0.0
Medication: Atorvastatin	1.0	1.2	3.5	0.4	-1.5	1.9	-0.5	0.2
Illnesses of father: High blood pressure	0.5	0.6	1.2	-1.0	-1.1	0.8	0.4	0.3
Alcohol drinker status: Never	0.4	0.4	1.3	-0.3	-0.6	-0.2	0.6	-1.1
Ever smoked	0.1	0.2	0.6	-0.2	-0.8	0.1	0.6	-0.1
Basal metabolic rate	0.6	3.5	9.3	-0.4	1.9	-3.1	0.7	-2.0
Leg fat percentage (left)	1.1	4.1	10.2	-3.2	-1.1	-2.0	1.4	-1.8
Arm fat-free mass (left)	1.0	5.1	14.0	-1.3	1.6	-3.7	1.2	-2.4
Number of operations (self-reported)	0.4	0.5	1.1	-0.7	-0.3	-1.0	-0.0	-1.1
Average weekly beer plus cider intake	1.0	1.5	3.5	-1.6	-1.9	-0.4	0.8	-0.6
Irritability	1.0	1.6	3.2	1.2	-1.1	1.8	-1.5	0.3
Risk taking	0.8	1.2	2.4	0.9	1.4	-0.3	-1.5	1.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.8	1.1	1.9	0.1	-1.3	0.3
Fractured/broken bones in last 5 years	0.9	1.1	2.6	-0.6	0.0	-1.6	-0.3	-1.6
Age started oral contraceptive pill	0.4	0.5	1.1	0.2	-0.7	-0.1	-1.0	-0.9
Diastolic blood pressure, automated reading	0.9	2.9	11.0	-3.3	-0.8	-1.3	1.1	0.0
Ever depressed for a whole week	0.5	0.6	1.4	-0.5	1.2	0.1	1.1	-0.1
Unable to work because of sickness or disability	0.3	0.4	1.0	0.7	0.5	-0.1	1.0	0.3
Commuting to job workplace: Cycle	1.5	1.8	3.6	1.7	1.9	0.8	-0.8	1.1
Myopia	1.3	1.9	3.7	1.9	1.7	0.8	-0.3	1.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.1	1.4	1.2	-0.4	0.1	0.5
Cholesterol lowering medication	0.9	1.3	2.7	-1.2	-1.5	-0.5	0.3	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.2	0.2	0.3	0.1	-0.5
Pain experienced in last month	0.2	0.4	1.2	0.5	0.3	0.4	-1.1	0.6
Supplements: Calcium	0.7	0.7	3.0	-0.0	1.7	-0.6	-0.3	0.3
Basal cell carcinoma (self-reported)	3.1	3.7	7.2	-1.5	-0.6	-2.4	1.7	-2.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	-0.5	-0.8	1.3	-0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.0	-0.2	0.3	-0.7	0.4	-1.7
Heart disease (siblings)	0.7	0.8	2.9	-0.7	-0.1	1.7	0.0	0.9
Alcohol drinker status: Previous	0.8	0.9	1.6	-0.9	0.3	-1.3	0.7	-1.2
Pack years of smoking	0.7	1.0	2.9	-1.7	0.0	-0.2	1.3	-0.5
Impedance of whole body	0.3	1.4	3.1	1.8	1.2	1.2	-0.9	-0.2
Leg fat mass (left)	0.9	3.6	6.7	-2.6	-0.3	-2.4	1.2	-2.0
Arm predicted mass (left)	0.8	4.0	11.2	-1.2	1.2	-3.4	1.1	-2.2