Hub : Genes

SERPINA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.1344 0.0222 1.4e-15 0.066 0.056 0.098 0.096 0.086 2.1e-20 1.3e-17 5.1e-30 2.1e-29 2.5e-26
2 YFS Blood 0.5410 0.0307 0.0e+00 0.235 0.413 0.450 0.428 0.431 1.4e-75 4.3e-148 3.1e-166 1.5e-155 1.2e-156
3 TCGA Breast Invasive Carcinoma 0.0198 0.0097 1.4e-03 0.009 0.013 0.008 NA 0.012 4.1e-03 9.8e-04 5.9e-03 NA 1.3e-03
4 TCGA Colon Adenocarcinoma 0.1240 0.0670 2.2e-03 0.052 0.049 0.081 NA 0.096 5.5e-04 8.5e-04 2.0e-05 NA 3.5e-06
5 TCGA Prostate Adenocarcinoma 0.0734 0.0349 2.4e-03 0.010 0.027 0.030 NA 0.009 3.1e-02 7.9e-04 3.7e-04 NA 3.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.2 1.9 5.1 -0.1 2.0 -2.2 0.9 -0.3
Bipolar Disorder or Schizophrenia 0.2 0.5 1.4 0.9 1.2 0.2 -0.0 0.3
Depressed Affect (Nagel 2018) 0.2 0.5 1.4 -0.7 -0.5 1.2 0.0 0.6
Depression (Nagel 2018) 1.2 1.9 4.9 -1.5 -0.3 -1.2 2.2 -0.8
Intelligence (Savage-Jansen 2018) 0.6 1.8 2.7 1.7 1.3 1.6 -0.9 1.1
Neuroticism (Nagel 2018) 0.2 0.4 0.8 -0.9 -0.7 0.6 0.2 0.1
Schizophrenia (2018) 0.7 1.4 4.3 1.3 -0.0 2.1 -0.7 0.6
Schizophrenia vs Biploar Disorder 2.2 2.9 6.3 1.8 -1.1 2.5 -1.3 1.3
Worry (Nagel 2018) 0.2 0.5 1.1 0.1 -1.0 1.1 -0.4 0.3
Alzheimer’s Disease (in mother) 0.6 0.7 3.3 -0.4 -0.1 -1.8 0.2 -0.3
Alzheimer’s Disease (in father) 1.5 1.6 5.1 -1.6 0.5 -0.2 2.3 -0.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 -0.8 -0.5 -0.9 0.2 -0.4
Crohns Disease (2017) 0.5 1.1 4.1 -0.1 0.1 -1.0 0.8 -2.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 -0.0 -0.1 0.4 0.5 -0.6
Ulcerative Colitis (UC) 0.2 0.3 1.5 -0.3 -0.3 1.2 0.1 0.2
Major Depression (MDD) 0.5 0.6 2.3 -0.6 0.6 -0.1 1.5 -0.2
Reaction Time 0.3 0.5 1.8 -0.2 0.4 -0.7 0.4 -1.4
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.1 1.8 0.5 1.1 -0.4 1.1
Breast Cancer 0.5 1.1 2.4 1.6 0.6 0.9 -1.4 0.4
Ovarian Cancer 0.4 0.5 1.1 1.1 -0.3 0.4 -1.0 0.1
Prostate Cancer 1.8 2.5 6.1 -1.9 -2.5 -0.4 1.5 -0.8
Age at First Birth 0.8 1.2 3.1 1.0 0.5 1.8 -0.8 1.0
Bipolar Disorder (2011) 1.2 1.2 2.9 -0.9 -0.0 -1.7 0.8 -1.3
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 1.3 0.9 0.5 -0.6 1.0
Coronary Artery Disease (CAD) 0.8 0.9 2.2 0.8 0.8 1.0 1.5 0.4
Crohns Disease (2012) 0.3 0.4 0.9 0.4 0.9 -0.4 0.2 -0.9
Mean Putamen Volume 0.5 0.6 1.3 0.9 -1.1 0.9 -0.3 0.0
Fasting Glucose 0.2 0.2 0.8 -0.5 -0.9 -0.1 0.3 0.2
HbA1C 0.3 0.3 0.6 0.5 0.7 0.2 0.0 0.8
HDL Cholesterol 0.7 1.2 1.5 -1.2 -0.9 -1.0 1.0 -1.2
LDL Cholesterol 0.5 0.8 3.0 0.5 -0.2 -0.7 -0.1 -1.7
Lupus 1.4 2.1 5.1 0.9 2.3 0.5 -1.0 1.9
Neuroticism (2016) 0.7 1.0 2.0 -0.6 -1.4 0.9 -0.9 0.9
Primary Biliary Cirrhosis 0.9 1.3 2.1 0.8 1.0 1.4 -0.9 1.4
Rheumatoid Arthritis 0.5 0.7 1.5 0.4 0.9 0.8 -0.6 1.2
Schizophrenia (2014) 0.3 0.7 1.7 1.3 0.3 1.0 -0.8 -0.1
Triglycerides 0.5 0.9 3.6 -0.2 1.9 -0.5 -0.6 0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.5 -0.5 -0.1 -0.6 1.6 0.3
Ulcerative Colitis 0.1 0.2 0.4 -0.2 0.1 0.6 -0.5 0.5
Blood Eosinophil Count 0.5 3.8 8.6 -2.0 1.7 -2.9 0.9 -1.7
Blood Platelet Count 1.2 14.5 31.6 -4.0 3.7 -5.6 1.0 -3.1
Blood Red Count 0.1 1.0 2.8 1.0 0.1 1.0 -1.7 -0.2
Blood White Count 0.4 2.9 9.8 -0.6 3.1 -1.6 -1.4 -0.1
Heel T-Score 0.2 1.4 4.9 0.6 0.3 1.0 -0.7 2.2
BMI 0.5 3.2 8.0 -2.8 -0.7 -1.7 1.0 -1.8
Height 0.6 12.4 32.5 2.6 2.3 -4.1 -1.0 -5.7
Waist Hip Ratio (WHR) 0.4 1.7 3.3 -1.6 -1.8 -1.4 -0.1 -0.9
Systolic Blood Pressure 0.5 2.3 8.2 -1.6 -2.9 0.5 -0.5 -0.4
Smoking Status 0.1 0.2 0.4 -0.2 -0.7 0.6 0.4 0.1
Allergy or Eczema 0.2 0.5 0.9 0.6 -0.0 0.9 -0.9 0.6
Cardiovascular Disease 0.1 0.3 0.9 -1.0 -0.2 0.1 0.2 -0.5
Hypothyroidism (self reported) 1.1 2.4 5.9 1.1 -0.9 1.8 -2.4 1.1
Respiratory disease 0.1 0.2 0.9 0.2 -0.1 0.2 -1.0 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.1 -0.1 -1.1 0.7 0.6 -0.1
Lung FEV1/FVC ratio 0.9 4.4 8.5 -1.7 -0.7 -2.5 2.0 -2.9
Lung FVC 0.8 4.3 10.8 3.3 1.3 0.6 -2.9 -0.4
Neuroticism 1.2 2.9 6.9 1.5 -0.1 2.6 -1.8 1.5
Chronotype (morning person) 0.6 1.4 2.9 -1.7 -0.9 -1.6 0.5 -0.7
Hair Pigment 0.0 0.4 1.3 0.7 0.2 -0.6 -1.1 0.1
Tanning 0.2 2.1 5.1 -1.2 -2.2 0.1 2.0 0.4
Hand grip strength (left) 0.7 1.8 3.8 -0.5 1.5 -1.9 1.4 -0.8
Number of treatments/medications taken 0.5 0.8 2.4 -1.5 -0.7 -0.5 0.7 -0.8
Average weekly spirits intake 1.3 1.7 5.1 -0.5 -2.3 0.4 1.1 -1.3
Sensitivity / hurt feelings 0.2 0.4 0.9 -0.1 0.9 -0.1 0.5 0.9
Frequency of depressed mood in last 2 weeks 2.4 3.4 7.8 -2.4 -0.1 -1.8 2.8 -0.1
Hearing difficulty/problems: Yes 0.5 0.7 2.8 0.8 1.7 -0.1 0.1 0.4
Relative age of first facial hair 0.8 1.6 5.3 2.3 1.3 0.6 -0.8 0.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 1.9 -0.5 1.4 -1.3 0.8 -1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.5 -0.6 -0.7 0.4 0.6 0.5
Ever had hysterectomy (womb removed) 1.1 1.2 2.9 0.9 -0.2 1.4 -1.7 0.7
Systolic blood pressure, automated reading 1.1 3.1 7.9 -2.7 -2.8 -0.6 -0.5 -0.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.3 1.1 -0.7 0.1 -0.7 0.5
Angina 1.2 1.6 5.5 -1.0 -2.3 1.1 0.1 -0.7
Medication for hormone replacement therapy 1.0 1.2 2.6 1.2 0.3 1.6 0.2 1.2
Vitamin and mineral supplements 0.2 0.3 0.9 -0.3 0.4 -0.3 0.9 -0.2
Supplements: Zinc 0.9 1.0 2.8 -0.9 -0.0 -1.1 -0.3 -1.7
Medication: Co-codamol 0.6 0.7 1.9 0.5 -1.0 0.8 0.1 1.4
Medication: Metformin 0.3 0.4 0.5 -0.4 -0.7 -0.6 0.7 -0.5
Diabetes (father) 1.8 2.3 8.3 0.9 0.6 1.3 -0.4 2.9
Diabetes (mother) 1.2 1.5 4.3 -1.1 -0.8 -1.0 2.1 -0.5
Severe depression (siblings) 1.5 1.7 3.4 0.9 -0.9 1.6 -1.8 1.1
Pack years adult smoking proportion 0.6 1.0 3.0 -1.7 0.1 -0.2 1.3 -0.4
Impedance of leg (right) 0.1 0.7 1.4 0.5 1.2 -0.2 -0.9 -0.9
Leg fat-free mass (left) 0.4 2.2 6.1 -0.1 1.6 -2.5 0.4 -1.4
Trunk fat percentage 0.6 2.4 4.4 -1.8 0.2 -2.1 0.8 -2.0
Hand grip strength (right) 0.4 1.2 3.4 0.3 1.8 -1.2 1.0 -0.4
Townsend deprivation index at recruitment 0.5 0.7 1.6 -0.9 1.3 -1.0 0.5 -0.3
Current tobacco smoking 0.5 0.9 3.2 0.5 -0.4 1.8 -0.2 0.9
Average weekly fortified wine intake 1.1 1.3 2.1 -0.9 -1.2 -1.5 -0.7 -1.3
Maternal smoking around birth 0.7 1.0 2.8 0.6 1.7 0.0 -0.3 1.3
Fed-up feelings 0.8 1.4 3.6 -1.9 -1.5 0.1 1.0 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 4.0 -1.1 0.5 -0.2 2.0 0.1
Relative age voice broke 0.1 0.1 0.3 0.6 0.2 -0.2 -0.1 -0.5
Taking other prescription medications 0.5 0.7 2.3 -0.3 -0.5 1.5 0.0 0.9
Age when periods started (menarche) 0.3 0.6 1.8 -0.8 0.0 -1.3 0.5 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.0 0.1 -0.9 1.0 -0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.7 0.3 -0.4 0.2 -1.3 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.7 0.4 -0.5 -0.8 0.8 -0.8
Qualifications: CSEs or equivalent 0.5 0.7 1.4 -1.1 -1.2 -0.8 0.4 -0.2
Serious illness, injury or assault to yourself 1.3 1.5 2.6 -1.3 0.4 -1.4 1.6 -1.0
High blood pressure 0.2 0.5 1.4 -1.2 -0.7 0.3 -0.2 -0.5
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.3 -0.1 0.5 -0.3 0.3 -0.2
Multivitamins +/- minerals 0.2 0.2 0.5 0.2 -0.5 0.1 -0.6 -0.7
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.2 0.7 -0.7 0.2 -0.1
Supplements: Glucosamine 0.3 0.3 0.9 -0.3 -0.8 -0.2 -1.0 -0.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.6 0.7 1.3 0.5 -0.8 0.7
Medication: Atenolol 1.2 1.5 3.4 0.7 -1.0 1.9 -1.5 0.6
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.6 -0.0 0.5 -0.3 0.7
Sitting height 0.3 2.3 4.2 1.4 2.0 -1.4 -0.0 -1.9
Chronic bronchitis/emphysema (father) 1.4 1.6 4.4 1.2 0.5 1.4 -2.1 -0.2
High blood pressure (mother) 0.1 0.2 0.3 -0.5 -0.3 0.6 -0.3 -0.5
Body mass index (BMI) 0.9 3.7 9.5 -3.1 -0.9 -2.2 1.3 -1.2
Impedance of leg (left) 0.1 0.3 0.8 0.2 0.6 0.2 -0.2 -0.9
Leg predicted mass (left) 0.4 2.4 6.7 -0.1 1.7 -2.6 0.5 -1.5
Trunk fat mass 0.7 2.9 6.1 -1.7 0.6 -2.5 0.6 -2.1
Waist circumference 0.7 2.7 6.0 -2.3 -0.2 -2.4 0.7 -1.2
Number of incorrect matches in round 0.8 1.3 2.9 -1.4 -0.8 -0.8 1.7 -0.2
Past tobacco smoking 0.1 0.2 0.9 -0.3 1.0 -0.1 0.3 0.0
Alcohol usually taken with meals 0.8 1.3 4.4 2.1 0.7 0.9 -0.8 0.4
Nervous feelings 0.9 1.8 3.5 0.4 -1.7 1.2 -1.9 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.7 -0.6 -0.5 -0.8 1.6 -0.3
Hearing difficulty/problems with background noise 0.3 0.5 1.4 0.9 -0.2 1.2 -0.4 0.2
Hair/balding pattern: Pattern 2 0.9 1.1 3.2 -1.8 -0.7 -0.6 0.6 1.1
Had menopause 1.1 1.3 4.0 -1.1 -2.0 0.8 0.9 0.1
Had other major operations 0.7 0.8 1.8 0.6 0.6 0.8 -1.3 1.0
Forced vital capacity (FVC) 0.9 3.6 8.4 2.9 2.4 -0.7 -1.6 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.7 0.0 0.1 0.1 -0.8 0.4
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 9.1 -2.0 0.9 -0.8 3.0 -1.1
Qualifications: None of the above 1.0 2.1 4.0 -2.0 -0.6 -1.4 1.4 -1.5
Financial difficulties in last 2 years 0.5 0.6 1.3 0.4 -0.9 1.1 -0.1 0.9
Mouth/teeth dental problems 0.6 0.9 2.1 0.7 0.3 0.9 -1.4 1.0
Heart attack 0.8 1.0 2.7 -0.3 -1.0 1.6 -0.9 0.7
Allergy 0.3 0.6 1.4 0.4 -0.6 1.2 -0.4 0.9
Pain all over the body in last month 0.2 0.3 0.6 0.5 -0.2 0.7 0.3 0.6
Diabetes (self-reported) 0.6 1.0 2.9 1.2 -0.6 1.7 0.0 0.2
Hayfever/allergic rhinitis (self-reported) 0.0 0.1 0.2 -0.1 0.3 0.2 0.4 -0.0
Medication: Ramipril 0.9 1.1 3.1 -1.3 -1.8 0.8 -0.3 -0.2
Medication: Simvastatin 0.4 0.6 2.8 0.2 -0.3 -0.2 -1.7 -0.4
Fluid intelligence score 1.2 2.6 5.9 2.4 1.0 1.7 -1.2 1.2
Illnesses of siblings 0.8 1.1 2.9 1.7 1.3 -0.2 0.2 0.8
Neuroticism score 0.4 0.9 2.1 0.3 -0.4 1.4 -0.6 1.4
Weight 0.8 4.0 10.0 -1.7 1.0 -3.2 0.8 -2.4
Impedance of arm (right) 0.8 3.7 9.7 3.1 1.1 1.9 -1.9 0.4
Arm fat percentage (right) 0.3 1.2 2.6 -1.6 -0.6 -1.2 0.6 -1.1
Trunk fat-free mass 0.6 3.5 9.1 0.2 2.1 -3.0 0.3 -2.0
Hip circumference 0.6 2.8 6.3 -1.5 1.5 -2.5 0.7 -1.6
Time employed in main current job 0.8 0.9 2.3 0.5 -0.5 0.1 -1.5 -1.3
Alcohol intake versus 10 years previously 0.7 1.0 2.1 -0.8 0.9 -1.1 1.5 -0.4
Father’s age at death 0.4 0.5 1.2 0.1 1.1 -0.6 0.8 -0.4
Worrier / anxious feelings 0.5 1.0 2.2 0.7 0.3 1.2 -1.5 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.2 -1.1 0.3 -0.7 0.9 -0.3
Falls in the last year 0.1 0.2 0.5 0.1 -0.1 0.6 -0.1 0.7
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.9 0.3 0.1 -0.8 0.2
Number of live births 0.2 0.3 0.6 0.7 0.1 0.6 -0.0 0.7
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.2 1.8 1.6 -1.3 -0.2 -1.3
Pulse rate 1.4 2.3 5.2 -1.8 0.9 -2.3 1.3 -0.9
Happiness 0.3 0.4 1.5 -0.4 0.0 -0.6 1.2 0.0
Noisy workplace 0.5 0.6 2.6 -0.3 -1.6 -0.2 -0.4 0.3
Qualifications: A levels/AS levels or equivalent 1.3 2.9 8.1 1.9 0.7 1.5 -2.8 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.0 0.8 1.1 -0.3 1.0 1.4
Mouth/teeth dental problems: Dentures 0.7 1.2 2.0 -0.8 0.8 -1.4 1.4 -1.0
Asthma 0.0 0.1 0.3 -0.5 0.1 -0.2 -0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 0.3 0.2 0.1 -0.5 -0.0
Medication: Cholesterol lowering 0.3 0.4 1.5 0.4 -0.4 0.5 -1.2 -0.3
Depression (self-reported) 1.7 2.0 4.4 -1.0 -0.2 -1.4 2.1 -1.6
Medication: Lansoprazole 0.6 0.7 1.1 -0.4 -1.1 1.0 -0.6 1.1
Prospective memory result 0.8 0.9 2.4 -1.2 0.6 -1.5 0.7 0.1
Lung cancer (father) 0.4 0.5 1.1 0.6 0.3 1.0 -0.7 0.7
Illnesses of mother 0.9 1.1 4.3 2.1 0.5 1.0 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 4.7 1.4 2.2 -1.6 -0.1 -1.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 -0.9 0.3 -0.4 1.1 0.4
Impedance of arm (left) 0.7 3.3 8.2 2.9 1.5 1.8 -1.5 0.3
Arm fat mass (right) 0.7 2.9 6.1 -2.0 0.1 -2.5 1.0 -1.9
Trunk predicted mass 0.6 3.5 8.9 0.2 2.0 -3.0 0.3 -2.1
Standing height 0.8 8.3 19.4 2.8 4.4 -2.4 -1.4 -2.5
Length of working week for main job 0.9 1.0 1.8 -0.3 1.1 -1.2 0.6 -1.3
Exposure to tobacco smoke at home 0.3 0.3 0.5 -0.6 -0.7 -0.1 -0.6 0.7
Breastfed as a baby 1.2 1.4 3.4 1.4 1.9 0.6 -1.3 -0.1
Tense / ‘highly strung’ 0.4 0.6 1.6 0.2 -0.2 1.0 0.5 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 7.0 -1.8 -0.9 -1.3 2.6 -1.1
Hair/balding pattern: Pattern 4 0.5 1.2 2.7 0.6 -1.6 1.5 -0.1 0.7
Birth weight of first child 0.5 0.8 1.7 1.1 1.3 -0.1 -0.4 1.0
Peak expiratory flow (PEF) 1.3 2.9 6.6 -0.4 1.9 -2.6 1.4 -1.6
Pulse wave reflection index 0.6 0.7 2.4 0.5 -0.2 0.7 1.6 0.6
Ever highly irritable/argumentative for 2 days 3.7 4.5 10.8 -3.3 -0.3 -1.9 2.4 -1.4
Loud music exposure frequency 0.5 0.5 2.0 -0.3 -0.8 -0.1 1.4 -0.1
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.0 1.7 0.6 0.5 -1.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.1 0.4 0.6 0.3 0.0
Blood clot in the leg (DVT) 0.6 0.8 3.0 -0.1 0.6 -0.7 0.5 -1.7
Medication: Paracetamol 0.4 0.6 1.4 -0.5 1.0 -1.2 -0.4 0.4
Headache pain in last month 0.3 0.5 1.3 -0.2 0.4 0.2 1.1 -1.0
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 3.5 1.6 1.2 1.0 0.4 1.9
Glaucoma (self-reported) 0.6 0.7 2.3 0.5 -0.3 1.5 -0.1 0.8
Gout (self-reported) 0.3 0.5 1.0 0.5 -0.0 1.0 -0.9 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 0.0 -0.4 0.9 -0.3 0.7
Medication: Amlodipine 3.0 4.2 6.2 -2.5 -1.8 -2.1 1.0 -2.5
Medication: Ventolin 100micrograms inhaler 1.2 1.6 4.0 -0.9 0.6 -1.2 1.1 -2.0
Birth weight 0.3 0.6 1.2 -0.6 -0.4 -0.8 1.1 -0.7
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.0 1.4 1.1 0.4 -0.8 0.7
High blood pressure (siblings) 2.2 3.2 8.2 -2.9 -1.5 -1.8 0.9 -1.2
Forced vital capacity (FVC), Best measure 1.0 3.6 9.4 2.3 3.1 -1.2 -0.9 -1.1
Body fat percentage 0.6 2.2 4.2 -2.1 -0.2 -1.9 0.7 -1.7
Leg fat percentage (right) 1.0 3.7 8.9 -3.0 -0.6 -2.2 1.0 -1.8
Arm fat-free mass (right) 0.9 4.4 11.1 -1.2 1.8 -3.3 1.3 -2.1
Exposure to tobacco smoke outside home 0.3 0.4 1.3 1.1 -0.2 -0.1 -0.7 -0.3
Comparative body size at age 10 0.0 0.1 0.3 -0.2 -0.6 -0.1 0.3 -0.3
Number of full brothers 0.2 0.2 0.6 0.5 0.3 -0.4 0.1 0.7
Worry too long after embarrassment 0.5 0.9 3.6 -0.4 0.2 0.8 0.2 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 4.4 -0.6 -0.5 0.2 2.1 -0.4
Wheeze or whistling in the chest in last year 0.2 0.4 1.8 -1.3 -0.1 -0.3 0.4 0.3
Number of children fathered 0.3 0.3 1.1 1.0 -0.3 0.1 -0.5 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 0.2 1.1 -0.3 1.3 0.6
Age at first live birth 1.5 2.6 6.1 1.2 2.5 0.4 -2.1 1.0
Pulse wave peak to peak time 0.7 0.8 1.9 1.3 -0.1 0.4 -1.4 -0.6
Health satisfaction 0.4 0.5 1.8 -0.3 -0.1 -0.7 1.3 -0.5
Shortness of breath walking on level ground 1.6 1.9 4.5 -1.0 0.7 -1.6 2.1 -0.9
Qualifications: College or University degree 0.3 1.0 2.8 0.5 1.1 -0.5 -1.7 0.7
Eye problems/disorders: None of the above 0.2 0.3 0.6 0.7 0.1 0.4 0.1 0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.7 -0.0 0.4 -0.4 0.8 -0.7
Emphysema/chronic bronchitis 1.4 1.6 2.1 1.5 1.1 1.2 -1.3 1.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.1 -0.6 -0.1 -0.5 1.0 -0.8
Neck or shoulder pain in last month 0.5 0.7 2.2 -0.8 -1.5 0.3 -0.0 -0.8
Medication: Blood pressure 0.9 1.5 2.8 -1.3 -1.7 -0.5 -0.8 -1.6
Angina (self-reported) 1.0 1.3 4.5 -0.8 -2.1 1.1 -0.0 -0.4
Migraine (self-reported) 0.9 1.1 4.8 0.5 2.2 -0.5 -0.5 0.2
Medication: Ibuprofen 0.3 0.3 0.8 0.5 0.6 -0.2 -0.9 -0.1
Medication: Allopurinol 1.2 1.5 3.3 1.7 0.4 1.1 -1.8 0.6
Medication: Omeprazole 0.2 0.2 1.1 -0.0 -0.1 0.1 -0.1 -1.0
Medication: Seretide 50 evohaler 0.5 0.6 1.5 -1.1 -0.6 -1.2 -0.1 -0.1
Mean time to correctly identify matches 0.5 1.0 3.6 -0.6 0.4 -0.8 0.2 -1.9
Heart disease (mother) 1.7 2.1 6.3 -2.5 -1.0 -1.7 -0.3 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.2 3.8 5.9 -2.4 -0.9 -1.7 1.9 -2.4
Whole body fat mass 0.7 2.7 6.5 -1.8 0.5 -2.6 0.7 -1.8
Leg fat mass (right) 0.9 3.4 6.2 -2.5 -0.2 -2.5 0.8 -1.9
Arm predicted mass (right) 0.7 3.6 9.9 -1.2 1.4 -3.1 1.1 -1.9
Pulse rate, automated reading 0.3 0.9 2.4 -1.5 -0.3 -0.5 0.8 -1.1
Alcohol intake frequency. 0.9 2.2 6.5 -0.6 0.1 -2.0 0.3 -2.5
Comparative height size at age 10 0.7 3.8 8.6 2.9 2.8 0.7 -1.4 -0.1
Number of full sisters 1.0 1.2 3.1 -0.2 1.8 -0.3 0.9 1.4
Suffer from ‘nerves’ 0.6 1.0 2.6 -1.4 -1.6 -0.0 0.6 -0.1
Overall health rating 0.2 0.5 0.9 -0.8 -0.5 0.3 0.9 -0.6
Chest pain or discomfort 0.1 0.2 0.4 -0.3 0.4 -0.6 0.1 -0.4
Had major operations 0.6 0.7 1.3 -1.1 -0.7 -0.5 0.3 -1.1
Age at last live birth 0.9 1.3 3.2 1.4 1.8 0.6 -0.9 0.5
Family relationship satisfaction 0.7 0.8 2.9 0.1 0.8 -0.8 1.7 -0.3
Leg pain on walking 0.7 0.9 3.7 -0.6 -0.1 0.1 1.9 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 4.2 -1.0 -2.1 0.6 2.0 0.8
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.7 -0.8 0.1 -1.6 1.4 -1.4
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.4 1.4 0.2 2.1 -0.9 0.4
Medication: Aspirin 1.0 1.3 3.5 0.1 -1.9 1.7 0.2 0.2
Supplements: Vitamin C 0.4 0.5 1.9 0.2 0.5 -0.2 -1.4 0.4
Knee pain experienced in last month 0.3 0.5 1.8 -0.4 -1.3 0.5 0.2 -0.6
Hypertension (Self-reported) 0.2 0.6 1.3 -1.0 -1.1 0.4 -0.2 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 2.1 -1.4 1.4 -1.5 1.4 -0.6
Illnesses of father: Heart disease 2.6 3.6 7.3 -2.6 -2.7 -0.7 1.0 -1.5
Illnesses of siblings: Diabetes 0.8 1.0 1.7 -0.7 -1.0 1.3 1.2 0.2
Smoking status: Previous 0.2 0.3 1.0 -0.2 -1.0 -0.5 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 16.5 2.3 4.1 0.4 -0.1 1.2
Whole body fat-free mass 0.5 2.9 7.6 0.1 1.9 -2.8 0.5 -1.7
Leg fat-free mass (right) 0.4 2.1 5.5 -0.2 1.6 -2.3 0.9 -1.4
Arm fat percentage (left) 0.4 1.5 3.0 -1.7 -0.5 -1.4 0.8 -1.2
Average weekly red wine intake 0.4 0.5 1.2 1.0 0.3 0.5 -1.1 -0.1
Handedness (chirality/laterality): Left-handed 1.7 2.0 3.4 -1.3 0.9 -1.8 1.5 -1.4
Mood swings 0.1 0.3 0.7 -0.9 -0.4 0.6 -0.1 0.3
Loneliness, isolation 1.1 1.5 3.8 0.3 -0.8 1.9 -0.3 1.7
Long-standing illness, disability or infirmity 1.0 1.6 4.0 -1.1 -0.5 -0.3 2.0 -1.6
Ever had bowel cancer screening 0.6 0.7 1.6 -0.3 -1.0 -0.8 -1.3 -0.3
Diabetes diagnosed by doctor 0.2 0.4 0.8 0.8 -0.1 0.9 0.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 0.2 0.8 -0.2 -0.6 0.5
Friendships satisfaction 0.7 0.8 1.3 1.0 0.8 1.1 0.2 1.2
Qualifications: nursing, teaching 2.7 4.2 9.5 2.7 1.0 1.6 -3.1 0.5
Commuting to job workplace: Walk 0.7 0.7 1.4 0.4 0.2 1.2 -1.0 1.1
Eye problems/disorders: Cataract 0.5 0.5 1.3 -1.2 -0.0 -1.0 -0.3 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.0 -0.9 -1.0 -1.3 0.8 -1.4
Medication for cholesterol 0.7 1.1 2.0 1.2 0.8 0.3 -1.4 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.9 -0.5 -1.0 -0.0 0.8 -0.8
Back pain experienced in last month 0.3 0.5 1.0 -0.7 0.8 -0.3 1.0 0.4
Mineral and other dietary supplements 0.2 0.2 0.5 -0.1 0.7 -0.7 0.4 0.1
Breast cancer (self-reported) 1.3 1.5 3.3 1.0 -0.1 1.4 -1.8 1.2
Asthma (self-reported) 0.1 0.1 0.3 -0.6 -0.1 -0.1 -0.1 -0.4
Osteoporosis (self-reported) 1.4 1.7 3.0 -1.2 1.4 -1.7 0.3 -1.5
Osteoarthritis (self-reported) 0.4 0.6 1.2 -1.1 -0.6 -1.0 -0.1 -0.4
Medication: Aspirin 1.0 1.3 3.9 -0.2 -2.0 1.4 0.6 -0.3
Medication: Gliclazide 0.4 0.5 1.4 0.3 -0.9 0.2 -0.1 1.2
Illnesses of father: None of the above (group 1) 0.5 0.6 1.5 1.2 0.8 -0.2 -0.7 0.5
Smoking status: Current 0.5 0.9 2.9 0.7 -0.3 1.7 -0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.2 1.0 1.4 -0.9 0.4 -1.5
Whole body water mass 0.5 3.1 8.4 -0.1 1.9 -2.9 0.6 -1.8
Leg predicted mass (right) 0.4 2.1 5.2 -0.2 1.6 -2.3 0.9 -1.3
Arm fat mass (left) 0.7 2.8 5.7 -1.9 0.1 -2.4 1.0 -1.9
Number of self-reported non-cancer illnesses 0.5 0.9 1.6 -1.2 0.9 -0.8 1.2 -0.6
Average weekly champagne plus white wine intake 1.0 1.3 2.1 0.8 1.2 0.9 -1.3 1.5
Miserableness 0.4 0.7 1.8 -1.3 0.3 -0.4 1.1 -0.4
Guilty feelings 0.5 0.8 2.0 -0.2 0.9 -0.6 1.4 0.7
Wears glasses or contact lenses 0.1 0.2 0.5 0.2 -0.7 0.4 -0.2 -0.1
Ever taken oral contraceptive pill 0.8 0.9 1.6 1.2 0.2 0.9 -0.7 1.2
Hearing aid user 0.8 0.9 2.2 0.2 1.5 -1.4 -0.5 -0.0
Mother’s age at death 0.1 0.1 0.2 0.5 0.1 -0.4 0.2 -0.0
Financial situation satisfaction 0.8 0.9 3.7 -0.1 -1.9 0.2 0.8 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.6 0.0 -0.2 -0.6 0.3 -0.8
Commuting to job workplace: Public transport 2.0 2.3 5.1 2.1 0.8 2.3 -0.8 1.0
Eye problems/disorders: Glaucoma 0.3 0.3 1.3 0.5 -0.1 1.2 0.2 0.1
Medication: Blood pressure 0.4 0.7 2.0 -1.4 -0.9 0.1 0.4 -0.7
Pain type(s) experienced in last month: Hip pain 0.7 0.8 3.0 -0.7 -1.7 0.1 0.4 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.3 0.5 -1.1 1.0 -1.1 -0.3
High cholesterol (Self-reported) 0.2 0.3 0.8 -0.5 -0.5 -0.5 -0.9 -0.3
Medication: Bendroflumethiazide 0.4 0.6 1.8 1.4 0.0 1.1 -0.1 -0.4
Medication: Paracetamol 0.6 0.9 2.6 -0.7 0.7 -1.6 -0.9 -0.4
Medication: Lisinopril 0.4 0.5 1.4 1.2 0.3 0.7 -0.7 -0.0
Medication: Atorvastatin 1.0 1.2 3.5 0.4 -1.5 1.9 -0.5 0.2
Illnesses of father: High blood pressure 0.5 0.6 1.2 -1.0 -1.1 0.8 0.4 0.3
Alcohol drinker status: Never 0.4 0.4 1.3 -0.3 -0.6 -0.2 0.6 -1.1
Ever smoked 0.1 0.2 0.6 -0.2 -0.8 0.1 0.6 -0.1
Basal metabolic rate 0.6 3.5 9.3 -0.4 1.9 -3.1 0.7 -2.0
Leg fat percentage (left) 1.1 4.1 10.2 -3.2 -1.1 -2.0 1.4 -1.8
Arm fat-free mass (left) 1.0 5.1 14.0 -1.3 1.6 -3.7 1.2 -2.4
Number of operations (self-reported) 0.4 0.5 1.1 -0.7 -0.3 -1.0 -0.0 -1.1
Average weekly beer plus cider intake 1.0 1.5 3.5 -1.6 -1.9 -0.4 0.8 -0.6
Irritability 1.0 1.6 3.2 1.2 -1.1 1.8 -1.5 0.3
Risk taking 0.8 1.2 2.4 0.9 1.4 -0.3 -1.5 1.0
Ever had prostate specific antigen (PSA) test 1.2 1.4 3.8 1.1 1.9 0.1 -1.3 0.3
Fractured/broken bones in last 5 years 0.9 1.1 2.6 -0.6 0.0 -1.6 -0.3 -1.6
Age started oral contraceptive pill 0.4 0.5 1.1 0.2 -0.7 -0.1 -1.0 -0.9
Diastolic blood pressure, automated reading 0.9 2.9 11.0 -3.3 -0.8 -1.3 1.1 0.0
Ever depressed for a whole week 0.5 0.6 1.4 -0.5 1.2 0.1 1.1 -0.1
Unable to work because of sickness or disability 0.3 0.4 1.0 0.7 0.5 -0.1 1.0 0.3
Commuting to job workplace: Cycle 1.5 1.8 3.6 1.7 1.9 0.8 -0.8 1.1
Myopia 1.3 1.9 3.7 1.9 1.7 0.8 -0.3 1.4
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.1 1.4 1.2 -0.4 0.1 0.5
Cholesterol lowering medication 0.9 1.3 2.7 -1.2 -1.5 -0.5 0.3 -1.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.2 0.2 0.3 0.1 -0.5
Pain experienced in last month 0.2 0.4 1.2 0.5 0.3 0.4 -1.1 0.6
Supplements: Calcium 0.7 0.7 3.0 -0.0 1.7 -0.6 -0.3 0.3
Basal cell carcinoma (self-reported) 3.1 3.7 7.2 -1.5 -0.6 -2.4 1.7 -2.7
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.7 -0.5 -0.8 1.3 -0.8 0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 3.0 -0.2 0.3 -0.7 0.4 -1.7
Heart disease (siblings) 0.7 0.8 2.9 -0.7 -0.1 1.7 0.0 0.9
Alcohol drinker status: Previous 0.8 0.9 1.6 -0.9 0.3 -1.3 0.7 -1.2
Pack years of smoking 0.7 1.0 2.9 -1.7 0.0 -0.2 1.3 -0.5
Impedance of whole body 0.3 1.4 3.1 1.8 1.2 1.2 -0.9 -0.2
Leg fat mass (left) 0.9 3.6 6.7 -2.6 -0.3 -2.4 1.2 -2.0
Arm predicted mass (left) 0.8 4.0 11.2 -1.2 1.2 -3.4 1.1 -2.2