Hub : Genes

SERPINA5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1547 0.0512 2.6e-03 0.011 NA 0.055 NA 0.033 4.4e-02 NA 4.5e-05 NA 1.5e-03
2 GTEx Muscle Skeletal 0.1686 0.0391 1.0e-05 0.162 NA 0.119 NA 0.150 1.3e-15 NA 1.0e-11 NA 1.4e-14
3 GTEx Nerve Tibial 0.2189 0.0547 1.2e-04 0.132 NA 0.107 NA 0.118 1.4e-09 NA 5.5e-08 NA 1.1e-08
4 TCGA Colon Adenocarcinoma 0.1220 0.0460 1.5e-04 0.117 0.044 0.066 NA 0.083 2.8e-07 1.4e-03 1.2e-04 NA 1.6e-05
5 TCGA Lung Adenocarcinoma 0.0700 0.0258 9.2e-06 0.033 0.041 0.050 NA 0.049 8.8e-05 1.3e-05 1.5e-06 NA 2.0e-06
6 TCGA Prostate Adenocarcinoma 0.0435 0.0195 2.8e-03 0.011 0.009 0.004 NA 0.007 2.1e-02 3.5e-02 1.0e-01 NA 5.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.1 0.1 0.4 0.1 -0.0 -0.4 -0.1 -0.3 -0.6
Bipolar Disorder or Schizophrenia 0.2 0.4 0.9 -0.5 -0.0 -0.3 -0.8 -0.8 -0.9
Depressed Affect (Nagel 2018) 1.4 2.9 8.2 0.6 -0.3 -0.8 -2.9 -2.6 1.2
Depression (Nagel 2018) 0.7 1.1 3.0 0.8 -1.6 0.4 -0.1 -0.2 1.7
Intelligence (Savage-Jansen 2018) 0.9 2.9 5.4 -2.0 1.3 -0.7 -1.8 -1.7 -2.3
Neuroticism (Nagel 2018) 0.5 1.2 2.0 0.8 -1.1 -0.3 -1.4 -1.4 1.2
Schizophrenia (2018) 0.2 0.4 1.0 -0.7 -0.0 -0.1 -1.0 -0.8 -0.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 -0.6 -0.2 0.7 0.5 0.2 0.8
Worry (Nagel 2018) 0.1 0.3 0.9 0.1 -0.3 0.3 -0.7 -0.9 -0.2
Alzheimer’s Disease (in mother) 0.5 0.6 2.1 0.1 -1.5 0.0 0.5 0.7 0.7
Alzheimer’s Disease (in father) 1.7 1.8 4.1 -0.3 -0.3 1.7 2.0 1.8 0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 -0.2 -0.8 0.7 1.3 1.0 0.4
Crohns Disease (2017) 0.3 0.7 1.6 0.2 0.1 0.5 -1.1 -1.3 -1.0
Irritable Bowel Disease (IBD) 0.4 1.0 2.2 0.0 0.6 0.1 -1.1 -1.5 -1.4
Ulcerative Colitis (UC) 0.4 0.7 2.0 -0.2 0.1 -0.7 -0.7 -1.2 -1.4
Major Depression (MDD) 0.6 0.7 2.1 1.0 -0.8 -0.5 -0.3 -0.0 1.4
Reaction Time 1.3 2.5 8.2 -0.3 -2.9 -0.5 -0.5 -0.2 2.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.5 -1.2 0.4 -0.0 0.1 0.2 -1.6
Breast Cancer 0.1 0.1 0.3 -0.3 -0.0 0.0 0.6 0.3 -0.5
Ovarian Cancer 3.2 4.3 9.9 1.5 -1.7 0.9 3.2 2.9 1.3
Prostate Cancer 1.6 2.2 5.1 -0.1 -1.2 0.4 -2.0 -1.6 2.3
Age at First Birth 0.7 1.0 3.0 -1.6 0.1 -0.3 -0.3 -0.6 -1.7
Bipolar Disorder (2011) 0.7 0.7 2.0 1.4 -0.8 -0.5 -0.5 -0.6 0.9
Body Mass Index (BMI) (2010) 0.8 1.0 5.6 -2.4 -0.1 -0.2 0.7 0.2 -0.2
Coronary Artery Disease (CAD) 2.9 3.5 8.8 -3.0 -2.1 -2.1 -1.1 -1.0 1.0
Crohns Disease (2012) 0.3 0.4 0.8 0.7 -0.7 0.1 -0.7 -0.9 -0.4
Mean Putamen Volume 0.7 0.8 2.1 -1.2 -1.4 -1.1 -0.2 -0.5 -0.1
Fasting Glucose 0.7 0.9 2.0 0.9 0.4 -0.5 -1.4 -1.2 0.8
HbA1C 0.6 0.7 1.3 0.1 -1.1 0.1 1.1 0.9 0.9
HDL Cholesterol 0.6 1.0 4.8 2.2 0.8 -0.2 -0.5 -0.1 -0.4
LDL Cholesterol 0.6 0.9 2.6 0.5 -0.6 -1.6 -0.8 -1.1 -0.7
Lupus 0.6 0.8 2.5 1.1 -1.6 -1.0 0.0 0.1 0.6
Neuroticism (2016) 1.4 2.0 4.5 -1.3 -1.1 -0.5 -1.4 -1.4 2.1
Primary Biliary Cirrhosis 0.5 0.8 2.4 0.7 0.6 1.5 0.4 0.3 0.9
Rheumatoid Arthritis 0.3 0.5 1.1 0.9 0.7 1.1 0.2 -0.0 0.6
Schizophrenia (2014) 0.4 0.8 1.7 -1.3 0.0 0.5 -1.1 -1.1 -0.5
Triglycerides 0.4 0.6 1.4 -1.2 -0.7 -0.5 -0.9 -0.8 0.5
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.5 -0.7 -1.2 -0.8 -0.1 0.1 0.9
Ulcerative Colitis 0.2 0.2 0.5 0.5 -0.1 -0.5 0.1 -0.6 -0.7
Blood Eosinophil Count 0.1 0.4 1.0 -1.0 0.3 0.9 -0.4 -0.3 0.3
Blood Platelet Count 0.3 3.4 9.5 -1.7 -2.0 1.2 -1.3 -1.0 3.1
Blood Red Count 0.1 1.3 3.6 -1.9 -1.1 -0.6 1.1 0.6 -0.9
Blood White Count 0.4 3.3 8.2 -1.0 -1.0 2.4 1.1 1.6 2.9
Heel T-Score 0.4 3.0 8.8 -3.0 -0.4 0.9 2.0 1.8 -0.8
BMI 0.1 0.4 2.1 -0.0 0.7 0.2 -0.3 -0.1 1.4
Height 0.4 7.6 28.3 -2.4 2.4 -1.8 -0.8 -1.3 -5.3
Waist Hip Ratio (WHR) 0.4 1.6 3.3 0.4 1.7 0.2 -1.6 -1.8 0.6
Systolic Blood Pressure 0.4 1.9 3.9 0.1 1.2 1.3 1.7 2.0 1.1
Smoking Status 0.1 0.3 0.7 0.5 -0.8 -0.4 0.1 0.5 0.6
Allergy or Eczema 0.2 0.5 1.4 1.2 -0.2 -1.2 0.1 0.1 -0.7
Cardiovascular Disease 0.2 0.8 2.7 -0.1 -0.8 -1.7 -0.7 -0.7 -0.6
Hypothyroidism (self reported) 0.3 0.8 2.2 -0.6 0.6 -1.0 -0.8 -1.5 -0.2
Respiratory disease 1.0 2.2 4.1 -1.0 1.4 2.0 2.0 1.5 0.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.4 0.2 -0.9 0.9 1.2 1.2 0.9
Lung FEV1/FVC ratio 0.4 2.2 5.5 -1.2 -0.7 -0.7 -2.2 -2.3 0.5
Lung FVC 0.2 1.2 2.8 -0.2 -1.0 -1.6 0.6 0.7 -1.7
Neuroticism 0.5 1.3 2.1 1.2 -1.4 -0.2 -1.1 -0.9 1.4
Chronotype (morning person) 1.1 2.4 7.2 -2.7 -0.8 1.6 1.2 1.5 0.9
Hair Pigment 0.0 0.4 0.6 0.6 -0.8 -0.7 0.6 0.6 0.4
Tanning 0.1 1.5 3.1 0.9 1.5 -0.4 -1.8 -1.5 -0.4
Hand grip strength (left) 0.1 0.2 0.5 -0.3 -0.4 -0.7 -0.5 0.1 -0.5
Number of treatments/medications taken 0.6 1.0 3.5 -0.3 1.9 0.0 -0.7 -1.4 -0.2
Average weekly spirits intake 0.9 1.1 2.4 -0.6 0.6 1.4 1.2 1.5 -0.0
Sensitivity / hurt feelings 0.5 0.9 2.4 0.2 -0.7 0.0 1.5 1.2 0.9
Frequency of depressed mood in last 2 weeks 0.6 0.9 3.1 0.7 0.0 1.2 -0.2 -0.1 1.8
Hearing difficulty/problems: Yes 0.3 0.5 2.9 -1.7 0.3 -0.2 0.1 0.2 -0.0
Relative age of first facial hair 0.2 0.5 1.4 -0.1 -1.1 1.2 0.2 0.6 -0.3
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 2.8 -0.6 0.9 -1.4 -1.7 -1.7 -1.7
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 -0.8 0.5 -0.1 -0.7 -1.0 -0.0
Ever had hysterectomy (womb removed) 1.0 1.1 3.2 0.2 0.2 0.9 1.4 1.8 0.7
Systolic blood pressure, automated reading 0.7 1.9 3.1 -0.6 1.3 1.6 1.7 1.8 0.9
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.7 -0.0 -1.9 0.5 0.4 0.7 1.2
Angina 0.9 1.2 2.3 1.5 -0.7 1.4 1.0 0.6 1.0
Medication for hormone replacement therapy 0.4 0.5 1.9 0.5 1.4 0.5 -0.4 -0.3 0.4
Vitamin and mineral supplements 1.0 1.4 3.7 0.4 -1.1 0.4 1.9 1.6 0.6
Supplements: Zinc 1.4 1.5 4.0 0.7 0.7 -1.0 -2.0 -1.6 -0.7
Medication: Co-codamol 2.3 2.6 9.0 -0.2 3.0 -0.4 -0.9 -1.5 -1.9
Medication: Metformin 0.2 0.3 1.2 -0.6 -1.1 -0.4 0.2 0.1 0.1
Diabetes (father) 0.4 0.4 1.3 -0.6 1.1 0.2 0.8 0.6 0.2
Diabetes (mother) 0.2 0.2 0.7 -0.6 -0.4 -0.1 -0.3 -0.3 0.8
Severe depression (siblings) 0.7 0.7 3.2 -1.8 0.5 -0.2 0.1 0.1 -1.0
Pack years adult smoking proportion 0.9 1.4 5.6 0.5 2.4 1.5 -0.2 0.0 0.6
Impedance of leg (right) 0.2 1.1 3.8 0.1 -2.0 0.0 -0.9 -1.2 0.7
Leg fat-free mass (left) 0.2 0.8 3.2 0.2 1.8 -0.2 0.8 0.8 -0.6
Trunk fat percentage 0.3 1.3 5.7 0.6 2.4 0.7 -0.5 -0.8 0.4
Hand grip strength (right) 0.3 0.7 2.4 -0.4 0.2 -1.1 -0.6 -0.4 -1.6
Townsend deprivation index at recruitment 0.2 0.3 1.1 1.0 -0.6 0.1 -0.5 -0.1 0.6
Current tobacco smoking 0.2 0.3 0.7 0.9 0.2 0.3 0.0 0.1 0.8
Average weekly fortified wine intake 0.8 0.9 2.0 0.6 -0.2 1.4 1.2 1.2 0.5
Maternal smoking around birth 0.3 0.4 0.7 -0.8 -0.4 0.8 0.3 0.4 0.8
Fed-up feelings 0.7 1.3 2.8 1.6 0.1 -0.6 -1.7 -1.1 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.0 0.8 -0.9 0.9 1.3 0.9 1.4
Relative age voice broke 0.6 0.9 1.8 0.5 -1.1 0.3 1.1 1.3 1.0
Taking other prescription medications 0.3 0.5 2.3 0.1 1.5 -0.3 -0.1 -0.7 -0.3
Age when periods started (menarche) 0.2 0.5 2.1 -0.1 -1.4 0.3 0.3 0.3 0.9
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.4 1.3 -0.9 -0.2 0.1 0.5 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 7.2 -2.7 -1.9 -0.9 -0.0 0.2 -0.1
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 3.1 0.5 0.4 -0.9 -1.8 -1.3 -0.6
Qualifications: CSEs or equivalent 0.7 0.9 2.0 -1.3 -1.0 -0.6 -0.6 -0.6 1.4
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -0.5 -0.6 -0.1 -1.1 -0.8 0.1
High blood pressure 0.3 0.8 2.1 -0.6 0.1 -1.5 -0.7 -0.9 -1.1
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.3 0.9 0.4 -0.8 0.2 0.4 -1.1
Multivitamins +/- minerals 2.0 2.5 7.1 0.5 0.5 -1.5 -2.7 -2.2 -0.5
Stomach or abdominal pain in last month 0.4 0.5 1.1 -0.0 1.0 0.3 0.8 0.4 -1.0
Supplements: Glucosamine 0.9 1.2 1.9 -1.0 0.6 -1.4 -1.2 -1.4 -0.7
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 -0.3 -0.0 0.3 0.0 0.2 0.0
Medication: Atenolol 0.2 0.2 0.7 0.8 -0.6 -0.1 0.1 -0.3 0.1
Medication: Levothyroxine sodium 0.5 0.9 2.9 -1.7 0.5 -0.3 -0.8 -1.1 -0.2
Sitting height 0.2 1.2 5.1 -0.4 0.7 -0.8 0.5 0.7 -2.3
Chronic bronchitis/emphysema (father) 0.9 1.0 1.8 -1.1 1.3 0.7 -1.4 -1.0 -0.1
High blood pressure (mother) 0.4 0.6 2.7 -1.6 -0.1 0.0 0.0 0.5 0.7
Body mass index (BMI) 0.2 0.8 1.9 0.8 1.4 0.7 0.4 0.4 1.3
Impedance of leg (left) 0.2 1.0 2.4 -0.4 -1.5 -0.1 -1.1 -1.3 0.5
Leg predicted mass (left) 0.1 0.8 3.1 0.2 1.8 -0.2 0.7 0.8 -0.6
Trunk fat mass 0.3 1.2 5.7 0.5 2.4 0.5 -0.5 -0.7 0.3
Waist circumference 0.2 0.8 3.9 0.4 2.0 0.3 -0.3 -0.3 0.6
Number of incorrect matches in round 0.3 0.5 1.9 1.4 0.6 -0.7 -0.1 0.0 -0.1
Past tobacco smoking 0.9 1.6 4.1 -1.2 0.5 -0.5 -1.7 -2.0 -0.7
Alcohol usually taken with meals 0.3 0.5 2.0 0.0 0.4 -0.1 0.9 0.1 -1.4
Nervous feelings 0.5 1.0 2.8 0.7 1.7 0.7 -0.7 -0.8 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.2 0.6 -0.1 0.9 0.7 0.6 1.1
Hearing difficulty/problems with background noise 0.7 1.1 4.4 -2.1 -0.0 0.1 1.0 1.0 -0.2
Hair/balding pattern: Pattern 2 1.1 1.3 3.5 -1.3 -0.1 -0.4 -1.9 -1.6 0.4
Had menopause 0.4 0.5 2.0 -1.4 0.2 -0.2 -0.5 -0.8 -0.2
Had other major operations 1.2 1.5 4.5 -2.1 -0.2 -1.1 -1.2 -1.3 0.1
Forced vital capacity (FVC) 0.4 1.7 4.7 0.8 -0.6 -2.2 0.3 0.0 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 9.7 -3.1 -1.5 -0.4 0.0 0.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.7 0.6 -1.3 -0.7 -0.4 -0.4 1.3
Qualifications: None of the above 0.2 0.5 0.8 0.9 0.2 -0.8 -0.4 -0.9 -0.5
Financial difficulties in last 2 years 0.7 1.0 1.4 1.2 1.0 0.9 1.1 1.2 0.3
Mouth/teeth dental problems 1.0 1.6 4.0 -1.2 -2.0 -0.2 1.4 1.3 0.7
Heart attack 0.3 0.4 2.0 1.4 0.0 0.1 -0.4 -0.6 -0.2
Allergy 0.4 0.9 1.9 -0.1 -1.0 -0.0 -1.2 -1.4 1.1
Pain all over the body in last month 2.2 2.4 6.9 -1.3 -0.8 -2.6 -1.1 -1.0 -1.7
Diabetes (self-reported) 0.2 0.2 0.8 -0.3 -0.9 0.5 0.4 0.3 0.4
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.1 0.6 1.7 1.8 0.8 1.3 1.3
Medication: Ramipril 1.7 2.2 6.1 0.6 1.0 2.5 1.5 1.6 0.9
Medication: Simvastatin 1.0 1.4 4.6 -0.3 0.1 -0.8 -1.7 -2.1 -0.3
Fluid intelligence score 0.4 0.9 2.8 -0.9 0.9 0.5 0.5 0.5 -1.7
Illnesses of siblings 0.3 0.4 1.5 -0.3 -0.0 0.1 1.2 0.7 -0.2
Neuroticism score 0.3 0.6 1.7 1.3 -0.1 0.6 -0.4 0.1 1.3
Weight 0.2 0.7 3.8 0.5 1.9 0.4 0.4 0.3 0.1
Impedance of arm (right) 0.1 0.7 1.2 1.0 1.0 1.1 -0.4 -0.5 -0.6
Arm fat percentage (right) 0.3 1.2 4.0 0.9 2.0 0.9 -0.6 -0.7 0.8
Trunk fat-free mass 0.1 0.4 0.8 -0.2 0.5 -0.7 0.7 0.9 -0.7
Hip circumference 0.1 0.6 1.7 -0.1 0.6 0.3 1.1 1.3 0.5
Time employed in main current job 0.4 0.5 2.0 -0.1 1.4 0.8 0.1 0.4 -0.4
Alcohol intake versus 10 years previously 0.5 0.8 2.6 -1.6 -1.2 0.4 0.3 0.5 0.5
Father’s age at death 0.6 0.8 1.6 -1.1 0.7 1.3 -0.7 -0.4 0.8
Worrier / anxious feelings 0.4 0.8 1.7 0.7 -0.3 -0.7 -1.2 -1.3 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.7 1.5 -0.5 1.3 0.6 0.5 2.2
Falls in the last year 1.0 1.3 5.3 -0.2 1.1 -0.5 -0.6 -0.9 -2.3
Hair/balding pattern: Pattern 3 0.3 0.4 0.9 -0.1 0.5 0.0 0.9 0.9 -0.6
Number of live births 1.7 2.5 4.6 -1.5 -1.5 -1.8 -1.6 -2.1 0.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 4.9 0.1 -0.7 -2.2 -0.8 -1.1 -1.9
Pulse rate 0.9 1.6 3.1 0.7 -1.3 0.8 1.4 1.8 1.1
Happiness 0.6 0.7 3.1 0.6 -0.2 0.6 0.1 0.5 1.7
Noisy workplace 1.1 1.4 2.7 -1.4 -1.6 -1.6 -0.7 -0.6 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.4 0.0 -0.3 1.2 0.8 1.1 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.7 7.6 0.0 2.8 0.0 0.0 -0.4 -1.5
Mouth/teeth dental problems: Dentures 0.2 0.3 0.5 0.6 0.7 0.7 -0.6 -0.5 0.0
Asthma 1.6 3.1 6.0 -1.0 1.9 1.7 2.5 2.1 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.2 0.2 -1.5 -1.0 0.1 0.0 0.8
Medication: Cholesterol lowering 0.1 0.2 0.7 0.1 0.9 0.7 0.3 -0.2 0.0
Depression (self-reported) 1.0 1.2 4.1 2.0 -0.2 -0.1 -0.4 -0.0 1.8
Medication: Lansoprazole 1.1 1.2 3.7 0.6 1.9 -0.1 -1.0 -1.5 -0.4
Prospective memory result 0.1 0.2 0.4 -0.6 0.7 0.0 -0.0 -0.4 0.3
Lung cancer (father) 1.0 1.2 3.0 -1.7 1.1 -0.1 -0.5 -1.0 -1.2
Illnesses of mother 0.4 0.5 1.4 0.8 0.9 -0.4 0.3 -0.1 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 3.1 -0.7 -1.0 -1.8 -1.1 -1.3 -1.7
Pulse wave Arterial Stiffness index 0.6 0.7 2.9 1.7 1.0 -0.0 0.4 -0.1 -0.0
Impedance of arm (left) 0.1 0.6 1.7 0.9 0.7 1.3 0.1 -0.1 -0.8
Arm fat mass (right) 0.2 0.7 3.1 0.5 1.8 0.4 -0.4 -0.4 0.4
Trunk predicted mass 0.1 0.4 0.8 -0.3 0.6 -0.6 0.7 0.9 -0.8
Standing height 0.1 1.4 5.7 -0.7 1.4 -0.6 -0.0 -0.1 -2.4
Length of working week for main job 0.7 0.8 3.0 -1.7 -0.0 0.5 -0.0 0.0 1.2
Exposure to tobacco smoke at home 0.5 0.5 1.3 0.2 0.3 0.7 1.2 1.0 0.4
Breastfed as a baby 0.5 0.6 1.5 -0.1 -1.1 -1.2 -0.8 -0.5 0.1
Tense / ‘highly strung’ 0.3 0.5 1.6 0.1 -0.1 0.7 0.9 1.3 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.2 0.9 -0.2 -1.1 -0.2 -0.3 -0.2
Hair/balding pattern: Pattern 4 0.4 1.0 2.2 1.3 -0.7 0.1 1.5 1.2 0.6
Birth weight of first child 0.5 0.8 3.4 -0.1 -0.3 -1.9 0.3 -0.1 -1.2
Peak expiratory flow (PEF) 0.3 0.8 1.4 0.1 0.3 -1.0 -1.2 -1.1 -1.0
Pulse wave reflection index 0.3 0.4 1.2 0.8 0.7 -0.4 -0.3 -1.1 -0.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 0.6 -0.9 0.0 -0.3 0.2 1.0
Loud music exposure frequency 0.9 1.0 1.9 -1.4 -1.3 -0.9 -1.1 -0.7 0.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.3 -0.4 0.6 1.5 0.0 0.3 0.4
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.2 0.8 -0.7 -0.5 -0.6 -1.1
Blood clot in the leg (DVT) 0.5 0.7 2.5 -1.6 -0.6 -0.7 0.3 0.4 -0.8
Medication: Paracetamol 0.5 0.7 2.3 0.4 -1.5 -0.9 0.2 -0.4 1.0
Headache pain in last month 0.2 0.4 1.5 0.5 -0.7 -0.2 0.3 0.1 1.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 -0.6 0.1 -0.3 0.3 0.4 -0.8
Glaucoma (self-reported) 0.5 0.5 2.1 -0.1 1.5 -0.2 -0.4 -0.6 -0.7
Gout (self-reported) 0.1 0.2 0.6 0.1 -0.4 0.2 0.8 0.5 0.1
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 5.0 -1.0 0.2 -1.5 -1.7 -2.2 -0.6
Medication: Amlodipine 0.9 1.3 2.9 0.2 1.5 1.7 1.2 0.8 0.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.5 0.3 0.5 0.8 1.6 1.4 0.1
Birth weight 0.2 0.4 1.3 -0.0 1.1 -0.1 0.3 0.1 -1.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.7 -1.1 0.5 0.8 -1.3 -1.0 -0.7
High blood pressure (siblings) 0.3 0.5 1.1 -0.7 0.6 -0.4 -1.0 -0.8 -0.1
Forced vital capacity (FVC), Best measure 0.6 2.0 6.0 -0.6 -0.8 -2.2 -0.2 -0.5 -2.4
Body fat percentage 0.3 1.2 4.0 0.8 2.0 0.7 -0.6 -0.9 0.9
Leg fat percentage (right) 0.3 0.9 2.5 1.0 0.9 0.4 -0.5 -0.9 1.6
Arm fat-free mass (right) 0.1 0.4 0.9 -0.9 0.7 -0.7 0.4 0.5 -0.3
Exposure to tobacco smoke outside home 0.9 1.2 2.6 0.5 -1.0 0.4 1.1 1.4 1.6
Comparative body size at age 10 0.4 1.0 2.0 0.2 0.8 -1.0 -1.4 -1.4 -0.8
Number of full brothers 0.6 0.8 1.3 -0.4 -0.4 -0.9 -1.1 -1.1 1.0
Worry too long after embarrassment 0.1 0.2 0.8 0.1 -0.9 0.1 -0.3 -0.1 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.4 1.2 0.4 -0.5 -0.0 0.1 -0.7
Wheeze or whistling in the chest in last year 0.7 1.3 2.9 -0.2 0.6 1.6 1.7 1.4 0.2
Number of children fathered 1.9 2.2 7.3 -2.7 1.0 -0.9 -1.0 -1.3 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.7 1.3 -0.3 -1.2 -0.4 -0.4 -1.2
Age at first live birth 0.5 0.9 1.7 1.3 -0.7 -0.0 -1.3 -0.7 0.9
Pulse wave peak to peak time 0.6 0.7 3.0 -1.7 -1.2 0.2 -0.1 0.4 -0.1
Health satisfaction 0.1 0.1 0.3 -0.2 0.4 -0.6 -0.3 0.0 0.2
Shortness of breath walking on level ground 0.0 0.0 0.2 -0.1 0.1 -0.2 -0.1 -0.2 0.4
Qualifications: College or University degree 0.4 1.3 4.4 -0.8 0.2 -1.0 -1.1 -0.8 -2.1
Eye problems/disorders: None of the above 0.6 0.7 3.2 1.8 0.8 0.5 -0.2 -0.1 0.4
Mouth/teeth dental problems: Loose teeth 1.8 2.2 7.8 2.8 1.3 1.2 -0.2 -0.1 1.5
Emphysema/chronic bronchitis 0.8 0.9 2.5 -0.1 1.2 1.6 0.7 0.8 0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 -0.6 -0.2 0.6 0.2 0.6 -0.7
Neck or shoulder pain in last month 0.8 1.2 4.2 0.6 -0.5 0.5 -1.2 -0.6 2.0
Medication: Blood pressure 0.2 0.4 0.9 0.7 0.6 0.9 -0.2 -0.3 0.9
Angina (self-reported) 0.9 1.2 2.4 1.6 -0.9 1.2 0.9 0.5 1.1
Migraine (self-reported) 0.1 0.1 0.4 -0.6 -0.3 0.0 -0.4 -0.0 -0.4
Medication: Ibuprofen 0.2 0.3 0.9 -0.1 -0.9 -0.4 -0.0 0.0 0.7
Medication: Allopurinol 0.9 1.2 3.5 1.9 -1.0 0.3 1.0 0.9 0.9
Medication: Omeprazole 0.2 0.2 0.4 0.7 0.1 0.3 -0.4 -0.4 0.5
Medication: Seretide 50 evohaler 1.2 1.4 4.0 -0.6 -0.3 1.1 2.0 1.6 0.1
Mean time to correctly identify matches 0.7 1.4 4.1 0.3 -2.0 -0.5 -0.3 -0.2 1.9
Heart disease (mother) 0.3 0.3 1.7 1.3 -0.1 -0.1 0.1 0.2 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 0.2 -0.9 -0.7 -0.7 -0.6 0.1
Whole body fat mass 0.2 1.0 4.3 0.6 2.1 0.4 -0.4 -0.6 0.6
Leg fat mass (right) 0.2 0.7 1.8 0.9 1.4 0.2 -0.2 -0.3 1.1
Arm predicted mass (right) 0.1 0.4 0.7 -0.8 0.5 -0.6 0.6 0.7 -0.5
Pulse rate, automated reading 0.0 0.2 0.3 0.2 0.5 0.5 0.6 0.3 0.1
Alcohol intake frequency. 0.6 1.4 4.5 -0.4 0.2 1.8 -0.7 -0.5 2.1
Comparative height size at age 10 0.2 1.0 4.2 0.2 2.1 0.0 0.2 0.1 -1.3
Number of full sisters 0.8 1.0 3.4 1.9 -0.4 0.7 -0.5 0.2 1.3
Suffer from ‘nerves’ 0.3 0.5 1.5 -0.6 0.7 0.3 -0.4 -0.6 -1.2
Overall health rating 0.4 0.8 2.7 0.2 0.7 0.6 -0.8 -0.6 1.7
Chest pain or discomfort 1.1 1.6 2.7 -1.1 -0.7 1.5 1.6 1.5 0.9
Had major operations 4.9 5.8 12.9 3.6 -1.3 1.4 2.6 2.5 2.2
Age at last live birth 0.5 0.7 2.2 1.5 -0.5 -0.6 0.5 0.5 1.0
Family relationship satisfaction 0.3 0.4 0.7 0.4 -0.0 -0.8 -0.8 -0.6 -0.6
Leg pain on walking 0.4 0.4 1.0 -0.4 -1.0 -0.6 1.0 0.4 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.9 0.5 -0.3 0.2 0.1 -0.4 0.9
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.3 1.1 0.5 0.1 0.7 0.7 -1.0
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 6.2 0.1 -2.5 -0.3 0.9 0.9 -0.3
Medication: Aspirin 0.6 0.8 2.6 0.9 1.6 0.9 -0.4 -0.7 0.3
Supplements: Vitamin C 0.6 0.7 2.3 -0.9 0.6 -0.4 -0.5 -0.7 -1.5
Knee pain experienced in last month 0.1 0.2 0.4 0.1 0.5 0.7 0.1 0.5 0.4
Hypertension (Self-reported) 0.2 0.6 1.4 -0.3 0.1 -1.2 -0.5 -0.7 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.8 -0.3 1.2 -0.9 0.6 0.2 -1.7
Illnesses of father: Heart disease 2.3 3.3 9.5 1.2 -3.1 -0.4 0.0 0.6 2.9
Illnesses of siblings: Diabetes 0.4 0.5 1.3 0.7 1.0 1.1 -0.3 0.2 -0.5
Smoking status: Previous 0.7 1.0 1.9 1.3 -1.0 -0.3 1.0 1.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.5 -0.3 0.5 -1.1 -0.2 0.3 -2.1
Whole body fat-free mass 0.1 0.5 1.3 -0.1 1.1 -0.5 0.7 0.8 -0.6
Leg fat-free mass (right) 0.2 1.0 4.1 0.0 2.0 -0.3 0.7 0.8 -0.9
Arm fat percentage (left) 0.2 0.9 3.4 0.6 1.8 0.9 -0.4 -0.5 0.6
Average weekly red wine intake 0.9 1.3 3.1 0.8 -0.1 1.4 1.8 1.4 -0.4
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 0.2 -0.6 0.1 0.7 0.7 -0.6
Mood swings 1.1 1.9 5.3 0.1 0.3 0.3 -2.3 -1.7 1.8
Loneliness, isolation 0.1 0.2 0.4 -0.2 -0.0 0.5 -0.4 -0.1 0.7
Long-standing illness, disability or infirmity 1.4 2.1 4.7 -0.6 0.6 -1.4 -1.7 -2.2 -1.5
Ever had bowel cancer screening 0.8 0.9 2.6 -1.6 0.8 -0.4 -0.3 -0.7 -1.3
Diabetes diagnosed by doctor 0.3 0.5 2.1 -0.6 -1.4 -0.4 0.2 0.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 6.8 0.1 -2.6 -1.0 0.0 0.1 0.7
Friendships satisfaction 0.3 0.4 0.9 -0.9 0.7 0.8 0.1 0.4 0.1
Qualifications: nursing, teaching 1.1 1.7 4.0 -2.0 1.6 0.0 -0.9 -0.9 -1.3
Commuting to job workplace: Walk 0.8 0.9 1.9 -0.6 -1.4 -0.4 -0.8 -0.5 1.4
Eye problems/disorders: Cataract 0.7 0.8 2.2 -1.5 -1.0 0.6 0.4 0.4 0.9
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.8 -0.8 0.1 -1.1 -1.3 -1.3 -0.7
Medication for cholesterol 0.6 1.0 2.7 0.3 -0.6 0.7 1.5 1.6 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.9 5.8 13.0 -1.8 1.8 -1.6 -3.3 -3.6 -1.1
Back pain experienced in last month 0.4 0.6 1.7 -1.3 -1.2 -0.7 -0.2 0.0 0.3
Mineral and other dietary supplements 1.9 2.5 4.9 1.7 -2.2 1.3 1.4 1.6 1.1
Breast cancer (self-reported) 0.5 0.6 1.4 -1.1 -0.7 0.2 -0.5 -0.1 1.2
Asthma (self-reported) 1.3 2.6 4.2 -1.2 2.0 1.7 2.1 1.6 -0.9
Osteoporosis (self-reported) 1.7 2.1 4.3 1.8 2.1 2.1 -0.3 0.1 0.9
Osteoarthritis (self-reported) 0.7 0.9 2.0 -1.4 1.1 -0.3 -0.8 -1.0 -0.9
Medication: Aspirin 0.7 0.9 3.3 0.5 1.8 1.3 -0.2 -0.5 0.5
Medication: Gliclazide 1.2 1.3 3.5 0.2 -1.6 1.0 0.7 0.5 1.9
Illnesses of father: None of the above (group 1) 1.0 1.2 3.0 -1.3 1.7 1.1 0.4 -0.3 -1.1
Smoking status: Current 0.3 0.5 0.7 0.4 0.4 0.8 0.8 0.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 3.5 -1.2 -0.7 -1.9 -1.0 -1.7 -1.6
Whole body water mass 0.1 0.5 1.1 -0.3 1.1 -0.6 0.5 0.7 -0.7
Leg predicted mass (right) 0.2 1.0 4.0 0.0 2.0 -0.3 0.6 0.8 -0.9
Arm fat mass (left) 0.2 0.7 3.3 0.6 1.8 0.4 -0.5 -0.4 0.4
Number of self-reported non-cancer illnesses 0.1 0.1 0.8 -0.2 0.9 0.0 -0.1 -0.1 -0.2
Average weekly champagne plus white wine intake 0.3 0.4 1.0 0.4 -0.9 0.6 -0.2 0.2 1.0
Miserableness 0.6 1.0 1.9 1.1 0.5 0.1 -1.4 -1.4 1.0
Guilty feelings 1.2 1.8 2.9 1.7 1.1 1.2 1.6 1.7 0.3
Wears glasses or contact lenses 1.0 1.1 2.6 0.5 -1.6 1.0 1.1 1.2 0.5
Ever taken oral contraceptive pill 1.0 1.1 4.8 -0.4 -2.2 -0.5 0.6 0.7 0.6
Hearing aid user 0.3 0.4 1.0 0.6 -0.5 -0.0 0.6 0.5 1.0
Mother’s age at death 0.1 0.2 0.3 -0.4 0.6 -0.1 0.0 -0.4 -0.6
Financial situation satisfaction 1.3 1.6 4.9 1.5 -0.3 1.2 0.5 0.6 2.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.8 1.3 -0.7 -0.3 0.3 0.2 1.3
Commuting to job workplace: Public transport 1.0 1.1 2.6 -0.9 1.6 1.1 1.0 0.9 -0.7
Eye problems/disorders: Glaucoma 1.2 1.4 2.7 -1.1 1.0 -1.0 -1.3 -1.6 -0.9
Medication: Blood pressure 1.2 2.3 3.0 -1.6 -0.0 -1.7 -1.6 -1.7 -1.6
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.0 -1.7 1.2 0.9 -0.0 0.1 -0.4
Supplements: Fish oil (including cod liver oil) 2.0 2.6 6.5 -1.8 2.5 -0.9 -1.3 -1.5 -1.2
High cholesterol (Self-reported) 0.8 1.4 3.1 0.2 1.2 -0.9 -1.8 -1.5 -0.6
Medication: Bendroflumethiazide 0.8 1.2 3.4 0.4 0.8 -1.8 -0.8 -1.1 -1.2
Medication: Paracetamol 0.3 0.5 1.4 0.4 -1.2 -0.1 0.6 0.2 0.9
Medication: Lisinopril 0.0 0.1 0.1 -0.1 0.2 0.3 0.3 0.4 -0.1
Medication: Atorvastatin 0.9 1.1 3.7 -1.9 1.1 1.0 -0.3 -0.7 0.2
Illnesses of father: High blood pressure 1.3 1.7 3.9 -0.3 -2.0 -1.8 -1.4 -0.9 -0.2
Alcohol drinker status: Never 0.5 0.6 1.3 1.1 0.5 -0.3 -1.0 -1.1 0.0
Ever smoked 0.7 1.2 3.7 0.1 -0.9 0.4 1.7 1.9 0.2
Basal metabolic rate 0.1 0.5 1.6 0.1 1.3 -0.4 0.5 0.7 -0.5
Leg fat percentage (left) 0.3 1.1 2.1 0.7 1.5 0.3 -0.8 -1.2 1.4
Arm fat-free mass (left) 0.1 0.3 1.0 -0.7 1.0 -0.4 0.3 0.4 -0.4
Number of operations (self-reported) 1.4 2.0 2.9 1.7 -1.5 0.2 1.4 1.4 1.7
Average weekly beer plus cider intake 1.1 1.6 4.0 0.4 1.3 1.3 2.0 1.5 0.3
Irritability 0.4 0.6 2.6 0.9 -0.2 -0.1 -0.2 0.5 1.6
Risk taking 0.8 1.2 1.6 1.2 -1.0 1.0 1.3 1.0 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 -0.5 0.0 1.2 0.6 0.9 0.8
Fractured/broken bones in last 5 years 0.3 0.4 0.6 -0.7 -0.8 0.7 0.6 0.5 -0.0
Age started oral contraceptive pill 0.1 0.2 0.6 0.8 -0.1 0.1 0.2 0.4 0.4
Diastolic blood pressure, automated reading 0.5 1.5 2.5 -0.8 0.4 1.4 1.6 1.3 1.4
Ever depressed for a whole week 0.3 0.3 1.1 0.2 0.4 -0.1 -1.0 -0.8 0.2
Unable to work because of sickness or disability 0.7 0.9 2.3 0.2 -1.3 -1.5 0.6 0.4 -0.8
Commuting to job workplace: Cycle 0.5 0.7 1.3 0.1 1.0 0.8 1.0 1.1 -0.0
Myopia 1.7 2.4 11.1 3.3 0.8 -0.2 0.4 0.1 -1.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.4 0.3 -0.2 1.1 0.9 1.2 1.1
Cholesterol lowering medication 2.4 3.6 9.3 -0.8 1.7 -1.0 -2.7 -3.0 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.6 1.6 1.2 -0.5 -0.7 -0.8 -0.7
Pain experienced in last month 0.3 0.5 1.4 0.4 1.2 0.3 -0.4 -0.7 -1.0
Supplements: Calcium 0.3 0.3 0.7 -0.3 -0.3 -0.9 -0.4 -0.6 -0.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 0.1 -0.7 -1.1 -0.6 -1.0 -1.0
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.6 1.6 -0.2 0.1 -0.3 -0.5 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 3.8 -1.9 -0.5 -0.8 0.2 0.2 -1.1
Heart disease (siblings) 0.3 0.3 0.6 0.3 -0.4 -0.0 0.7 0.7 -0.7
Alcohol drinker status: Previous 1.0 1.1 2.5 -0.9 1.0 0.7 -1.4 -1.6 -0.2
Pack years of smoking 1.1 1.6 6.7 0.6 2.6 1.5 -0.4 -0.2 0.5
Impedance of whole body 0.0 0.2 0.7 0.5 -0.2 0.8 -0.3 -0.6 -0.0
Leg fat mass (left) 0.2 0.8 2.6 0.7 1.6 0.3 -0.3 -0.5 1.0
Arm predicted mass (left) 0.1 0.3 1.2 -0.1 1.1 -0.4 0.3 0.5 -0.2