Hub : Genes

SERPINA5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1547	0.0512	2.6e-03	0.011	NA	0.055	NA	0.033	4.4e-02	NA	4.5e-05	NA	1.5e-03
2	GTEx	Muscle Skeletal	0.1686	0.0391	1.0e-05	0.162	NA	0.119	NA	0.150	1.3e-15	NA	1.0e-11	NA	1.4e-14
3	GTEx	Nerve Tibial	0.2189	0.0547	1.2e-04	0.132	NA	0.107	NA	0.118	1.4e-09	NA	5.5e-08	NA	1.1e-08
4	TCGA	Colon Adenocarcinoma	0.1220	0.0460	1.5e-04	0.117	0.044	0.066	NA	0.083	2.8e-07	1.4e-03	1.2e-04	NA	1.6e-05
5	TCGA	Lung Adenocarcinoma	0.0700	0.0258	9.2e-06	0.033	0.041	0.050	NA	0.049	8.8e-05	1.3e-05	1.5e-06	NA	2.0e-06
6	TCGA	Prostate Adenocarcinoma	0.0435	0.0195	2.8e-03	0.011	0.009	0.004	NA	0.007	2.1e-02	3.5e-02	1.0e-01	NA	5.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.1	0.4	0.1	-0.0	-0.4	-0.1	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	-0.5	-0.0	-0.3	-0.8	-0.8	-0.9
Depressed Affect (Nagel 2018)	1.4	2.9	8.2	0.6	-0.3	-0.8	-2.9	-2.6	1.2
Depression (Nagel 2018)	0.7	1.1	3.0	0.8	-1.6	0.4	-0.1	-0.2	1.7
Intelligence (Savage-Jansen 2018)	0.9	2.9	5.4	-2.0	1.3	-0.7	-1.8	-1.7	-2.3
Neuroticism (Nagel 2018)	0.5	1.2	2.0	0.8	-1.1	-0.3	-1.4	-1.4	1.2
Schizophrenia (2018)	0.2	0.4	1.0	-0.7	-0.0	-0.1	-1.0	-0.8	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.6	-0.2	0.7	0.5	0.2	0.8
Worry (Nagel 2018)	0.1	0.3	0.9	0.1	-0.3	0.3	-0.7	-0.9	-0.2
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	0.1	-1.5	0.0	0.5	0.7	0.7
Alzheimer’s Disease (in father)	1.7	1.8	4.1	-0.3	-0.3	1.7	2.0	1.8	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	-0.2	-0.8	0.7	1.3	1.0	0.4
Crohns Disease (2017)	0.3	0.7	1.6	0.2	0.1	0.5	-1.1	-1.3	-1.0
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	0.0	0.6	0.1	-1.1	-1.5	-1.4
Ulcerative Colitis (UC)	0.4	0.7	2.0	-0.2	0.1	-0.7	-0.7	-1.2	-1.4
Major Depression (MDD)	0.6	0.7	2.1	1.0	-0.8	-0.5	-0.3	-0.0	1.4
Reaction Time	1.3	2.5	8.2	-0.3	-2.9	-0.5	-0.5	-0.2	2.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.5	-1.2	0.4	-0.0	0.1	0.2	-1.6
Breast Cancer	0.1	0.1	0.3	-0.3	-0.0	0.0	0.6	0.3	-0.5
Ovarian Cancer	3.2	4.3	9.9	1.5	-1.7	0.9	3.2	2.9	1.3
Prostate Cancer	1.6	2.2	5.1	-0.1	-1.2	0.4	-2.0	-1.6	2.3
Age at First Birth	0.7	1.0	3.0	-1.6	0.1	-0.3	-0.3	-0.6	-1.7
Bipolar Disorder (2011)	0.7	0.7	2.0	1.4	-0.8	-0.5	-0.5	-0.6	0.9
Body Mass Index (BMI) (2010)	0.8	1.0	5.6	-2.4	-0.1	-0.2	0.7	0.2	-0.2
Coronary Artery Disease (CAD)	2.9	3.5	8.8	-3.0	-2.1	-2.1	-1.1	-1.0	1.0
Crohns Disease (2012)	0.3	0.4	0.8	0.7	-0.7	0.1	-0.7	-0.9	-0.4
Mean Putamen Volume	0.7	0.8	2.1	-1.2	-1.4	-1.1	-0.2	-0.5	-0.1
Fasting Glucose	0.7	0.9	2.0	0.9	0.4	-0.5	-1.4	-1.2	0.8
HbA1C	0.6	0.7	1.3	0.1	-1.1	0.1	1.1	0.9	0.9
HDL Cholesterol	0.6	1.0	4.8	2.2	0.8	-0.2	-0.5	-0.1	-0.4
LDL Cholesterol	0.6	0.9	2.6	0.5	-0.6	-1.6	-0.8	-1.1	-0.7
Lupus	0.6	0.8	2.5	1.1	-1.6	-1.0	0.0	0.1	0.6
Neuroticism (2016)	1.4	2.0	4.5	-1.3	-1.1	-0.5	-1.4	-1.4	2.1
Primary Biliary Cirrhosis	0.5	0.8	2.4	0.7	0.6	1.5	0.4	0.3	0.9
Rheumatoid Arthritis	0.3	0.5	1.1	0.9	0.7	1.1	0.2	-0.0	0.6
Schizophrenia (2014)	0.4	0.8	1.7	-1.3	0.0	0.5	-1.1	-1.1	-0.5
Triglycerides	0.4	0.6	1.4	-1.2	-0.7	-0.5	-0.9	-0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.5	-0.7	-1.2	-0.8	-0.1	0.1	0.9
Ulcerative Colitis	0.2	0.2	0.5	0.5	-0.1	-0.5	0.1	-0.6	-0.7
Blood Eosinophil Count	0.1	0.4	1.0	-1.0	0.3	0.9	-0.4	-0.3	0.3
Blood Platelet Count	0.3	3.4	9.5	-1.7	-2.0	1.2	-1.3	-1.0	3.1
Blood Red Count	0.1	1.3	3.6	-1.9	-1.1	-0.6	1.1	0.6	-0.9
Blood White Count	0.4	3.3	8.2	-1.0	-1.0	2.4	1.1	1.6	2.9
Heel T-Score	0.4	3.0	8.8	-3.0	-0.4	0.9	2.0	1.8	-0.8
BMI	0.1	0.4	2.1	-0.0	0.7	0.2	-0.3	-0.1	1.4
Height	0.4	7.6	28.3	-2.4	2.4	-1.8	-0.8	-1.3	-5.3
Waist Hip Ratio (WHR)	0.4	1.6	3.3	0.4	1.7	0.2	-1.6	-1.8	0.6
Systolic Blood Pressure	0.4	1.9	3.9	0.1	1.2	1.3	1.7	2.0	1.1
Smoking Status	0.1	0.3	0.7	0.5	-0.8	-0.4	0.1	0.5	0.6
Allergy or Eczema	0.2	0.5	1.4	1.2	-0.2	-1.2	0.1	0.1	-0.7
Cardiovascular Disease	0.2	0.8	2.7	-0.1	-0.8	-1.7	-0.7	-0.7	-0.6
Hypothyroidism (self reported)	0.3	0.8	2.2	-0.6	0.6	-1.0	-0.8	-1.5	-0.2
Respiratory disease	1.0	2.2	4.1	-1.0	1.4	2.0	2.0	1.5	0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.4	0.2	-0.9	0.9	1.2	1.2	0.9
Lung FEV1/FVC ratio	0.4	2.2	5.5	-1.2	-0.7	-0.7	-2.2	-2.3	0.5
Lung FVC	0.2	1.2	2.8	-0.2	-1.0	-1.6	0.6	0.7	-1.7
Neuroticism	0.5	1.3	2.1	1.2	-1.4	-0.2	-1.1	-0.9	1.4
Chronotype (morning person)	1.1	2.4	7.2	-2.7	-0.8	1.6	1.2	1.5	0.9
Hair Pigment	0.0	0.4	0.6	0.6	-0.8	-0.7	0.6	0.6	0.4
Tanning	0.1	1.5	3.1	0.9	1.5	-0.4	-1.8	-1.5	-0.4
Hand grip strength (left)	0.1	0.2	0.5	-0.3	-0.4	-0.7	-0.5	0.1	-0.5
Number of treatments/medications taken	0.6	1.0	3.5	-0.3	1.9	0.0	-0.7	-1.4	-0.2
Average weekly spirits intake	0.9	1.1	2.4	-0.6	0.6	1.4	1.2	1.5	-0.0
Sensitivity / hurt feelings	0.5	0.9	2.4	0.2	-0.7	0.0	1.5	1.2	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.1	0.7	0.0	1.2	-0.2	-0.1	1.8
Hearing difficulty/problems: Yes	0.3	0.5	2.9	-1.7	0.3	-0.2	0.1	0.2	-0.0
Relative age of first facial hair	0.2	0.5	1.4	-0.1	-1.1	1.2	0.2	0.6	-0.3
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.8	-0.6	0.9	-1.4	-1.7	-1.7	-1.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-0.8	0.5	-0.1	-0.7	-1.0	-0.0
Ever had hysterectomy (womb removed)	1.0	1.1	3.2	0.2	0.2	0.9	1.4	1.8	0.7
Systolic blood pressure, automated reading	0.7	1.9	3.1	-0.6	1.3	1.6	1.7	1.8	0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.7	-0.0	-1.9	0.5	0.4	0.7	1.2
Angina	0.9	1.2	2.3	1.5	-0.7	1.4	1.0	0.6	1.0
Medication for hormone replacement therapy	0.4	0.5	1.9	0.5	1.4	0.5	-0.4	-0.3	0.4
Vitamin and mineral supplements	1.0	1.4	3.7	0.4	-1.1	0.4	1.9	1.6	0.6
Supplements: Zinc	1.4	1.5	4.0	0.7	0.7	-1.0	-2.0	-1.6	-0.7
Medication: Co-codamol	2.3	2.6	9.0	-0.2	3.0	-0.4	-0.9	-1.5	-1.9
Medication: Metformin	0.2	0.3	1.2	-0.6	-1.1	-0.4	0.2	0.1	0.1
Diabetes (father)	0.4	0.4	1.3	-0.6	1.1	0.2	0.8	0.6	0.2
Diabetes (mother)	0.2	0.2	0.7	-0.6	-0.4	-0.1	-0.3	-0.3	0.8
Severe depression (siblings)	0.7	0.7	3.2	-1.8	0.5	-0.2	0.1	0.1	-1.0
Pack years adult smoking proportion	0.9	1.4	5.6	0.5	2.4	1.5	-0.2	0.0	0.6
Impedance of leg (right)	0.2	1.1	3.8	0.1	-2.0	0.0	-0.9	-1.2	0.7
Leg fat-free mass (left)	0.2	0.8	3.2	0.2	1.8	-0.2	0.8	0.8	-0.6
Trunk fat percentage	0.3	1.3	5.7	0.6	2.4	0.7	-0.5	-0.8	0.4
Hand grip strength (right)	0.3	0.7	2.4	-0.4	0.2	-1.1	-0.6	-0.4	-1.6
Townsend deprivation index at recruitment	0.2	0.3	1.1	1.0	-0.6	0.1	-0.5	-0.1	0.6
Current tobacco smoking	0.2	0.3	0.7	0.9	0.2	0.3	0.0	0.1	0.8
Average weekly fortified wine intake	0.8	0.9	2.0	0.6	-0.2	1.4	1.2	1.2	0.5
Maternal smoking around birth	0.3	0.4	0.7	-0.8	-0.4	0.8	0.3	0.4	0.8
Fed-up feelings	0.7	1.3	2.8	1.6	0.1	-0.6	-1.7	-1.1	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	0.8	-0.9	0.9	1.3	0.9	1.4
Relative age voice broke	0.6	0.9	1.8	0.5	-1.1	0.3	1.1	1.3	1.0
Taking other prescription medications	0.3	0.5	2.3	0.1	1.5	-0.3	-0.1	-0.7	-0.3
Age when periods started (menarche)	0.2	0.5	2.1	-0.1	-1.4	0.3	0.3	0.3	0.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.4	1.3	-0.9	-0.2	0.1	0.5	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	7.2	-2.7	-1.9	-0.9	-0.0	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.1	0.5	0.4	-0.9	-1.8	-1.3	-0.6
Qualifications: CSEs or equivalent	0.7	0.9	2.0	-1.3	-1.0	-0.6	-0.6	-0.6	1.4
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-0.5	-0.6	-0.1	-1.1	-0.8	0.1
High blood pressure	0.3	0.8	2.1	-0.6	0.1	-1.5	-0.7	-0.9	-1.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.3	0.9	0.4	-0.8	0.2	0.4	-1.1
Multivitamins +/- minerals	2.0	2.5	7.1	0.5	0.5	-1.5	-2.7	-2.2	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.0	1.0	0.3	0.8	0.4	-1.0
Supplements: Glucosamine	0.9	1.2	1.9	-1.0	0.6	-1.4	-1.2	-1.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	-0.3	-0.0	0.3	0.0	0.2	0.0
Medication: Atenolol	0.2	0.2	0.7	0.8	-0.6	-0.1	0.1	-0.3	0.1
Medication: Levothyroxine sodium	0.5	0.9	2.9	-1.7	0.5	-0.3	-0.8	-1.1	-0.2
Sitting height	0.2	1.2	5.1	-0.4	0.7	-0.8	0.5	0.7	-2.3
Chronic bronchitis/emphysema (father)	0.9	1.0	1.8	-1.1	1.3	0.7	-1.4	-1.0	-0.1
High blood pressure (mother)	0.4	0.6	2.7	-1.6	-0.1	0.0	0.0	0.5	0.7
Body mass index (BMI)	0.2	0.8	1.9	0.8	1.4	0.7	0.4	0.4	1.3
Impedance of leg (left)	0.2	1.0	2.4	-0.4	-1.5	-0.1	-1.1	-1.3	0.5
Leg predicted mass (left)	0.1	0.8	3.1	0.2	1.8	-0.2	0.7	0.8	-0.6
Trunk fat mass	0.3	1.2	5.7	0.5	2.4	0.5	-0.5	-0.7	0.3
Waist circumference	0.2	0.8	3.9	0.4	2.0	0.3	-0.3	-0.3	0.6
Number of incorrect matches in round	0.3	0.5	1.9	1.4	0.6	-0.7	-0.1	0.0	-0.1
Past tobacco smoking	0.9	1.6	4.1	-1.2	0.5	-0.5	-1.7	-2.0	-0.7
Alcohol usually taken with meals	0.3	0.5	2.0	0.0	0.4	-0.1	0.9	0.1	-1.4
Nervous feelings	0.5	1.0	2.8	0.7	1.7	0.7	-0.7	-0.8	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	0.6	-0.1	0.9	0.7	0.6	1.1
Hearing difficulty/problems with background noise	0.7	1.1	4.4	-2.1	-0.0	0.1	1.0	1.0	-0.2
Hair/balding pattern: Pattern 2	1.1	1.3	3.5	-1.3	-0.1	-0.4	-1.9	-1.6	0.4
Had menopause	0.4	0.5	2.0	-1.4	0.2	-0.2	-0.5	-0.8	-0.2
Had other major operations	1.2	1.5	4.5	-2.1	-0.2	-1.1	-1.2	-1.3	0.1
Forced vital capacity (FVC)	0.4	1.7	4.7	0.8	-0.6	-2.2	0.3	0.0	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	9.7	-3.1	-1.5	-0.4	0.0	0.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	0.6	-1.3	-0.7	-0.4	-0.4	1.3
Qualifications: None of the above	0.2	0.5	0.8	0.9	0.2	-0.8	-0.4	-0.9	-0.5
Financial difficulties in last 2 years	0.7	1.0	1.4	1.2	1.0	0.9	1.1	1.2	0.3
Mouth/teeth dental problems	1.0	1.6	4.0	-1.2	-2.0	-0.2	1.4	1.3	0.7
Heart attack	0.3	0.4	2.0	1.4	0.0	0.1	-0.4	-0.6	-0.2
Allergy	0.4	0.9	1.9	-0.1	-1.0	-0.0	-1.2	-1.4	1.1
Pain all over the body in last month	2.2	2.4	6.9	-1.3	-0.8	-2.6	-1.1	-1.0	-1.7
Diabetes (self-reported)	0.2	0.2	0.8	-0.3	-0.9	0.5	0.4	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	0.6	1.7	1.8	0.8	1.3	1.3
Medication: Ramipril	1.7	2.2	6.1	0.6	1.0	2.5	1.5	1.6	0.9
Medication: Simvastatin	1.0	1.4	4.6	-0.3	0.1	-0.8	-1.7	-2.1	-0.3
Fluid intelligence score	0.4	0.9	2.8	-0.9	0.9	0.5	0.5	0.5	-1.7
Illnesses of siblings	0.3	0.4	1.5	-0.3	-0.0	0.1	1.2	0.7	-0.2
Neuroticism score	0.3	0.6	1.7	1.3	-0.1	0.6	-0.4	0.1	1.3
Weight	0.2	0.7	3.8	0.5	1.9	0.4	0.4	0.3	0.1
Impedance of arm (right)	0.1	0.7	1.2	1.0	1.0	1.1	-0.4	-0.5	-0.6
Arm fat percentage (right)	0.3	1.2	4.0	0.9	2.0	0.9	-0.6	-0.7	0.8
Trunk fat-free mass	0.1	0.4	0.8	-0.2	0.5	-0.7	0.7	0.9	-0.7
Hip circumference	0.1	0.6	1.7	-0.1	0.6	0.3	1.1	1.3	0.5
Time employed in main current job	0.4	0.5	2.0	-0.1	1.4	0.8	0.1	0.4	-0.4
Alcohol intake versus 10 years previously	0.5	0.8	2.6	-1.6	-1.2	0.4	0.3	0.5	0.5
Father’s age at death	0.6	0.8	1.6	-1.1	0.7	1.3	-0.7	-0.4	0.8
Worrier / anxious feelings	0.4	0.8	1.7	0.7	-0.3	-0.7	-1.2	-1.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.7	1.5	-0.5	1.3	0.6	0.5	2.2
Falls in the last year	1.0	1.3	5.3	-0.2	1.1	-0.5	-0.6	-0.9	-2.3
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	-0.1	0.5	0.0	0.9	0.9	-0.6
Number of live births	1.7	2.5	4.6	-1.5	-1.5	-1.8	-1.6	-2.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.9	0.1	-0.7	-2.2	-0.8	-1.1	-1.9
Pulse rate	0.9	1.6	3.1	0.7	-1.3	0.8	1.4	1.8	1.1
Happiness	0.6	0.7	3.1	0.6	-0.2	0.6	0.1	0.5	1.7
Noisy workplace	1.1	1.4	2.7	-1.4	-1.6	-1.6	-0.7	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	0.0	-0.3	1.2	0.8	1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	7.6	0.0	2.8	0.0	0.0	-0.4	-1.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.6	0.7	0.7	-0.6	-0.5	0.0
Asthma	1.6	3.1	6.0	-1.0	1.9	1.7	2.5	2.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	0.2	-1.5	-1.0	0.1	0.0	0.8
Medication: Cholesterol lowering	0.1	0.2	0.7	0.1	0.9	0.7	0.3	-0.2	0.0
Depression (self-reported)	1.0	1.2	4.1	2.0	-0.2	-0.1	-0.4	-0.0	1.8
Medication: Lansoprazole	1.1	1.2	3.7	0.6	1.9	-0.1	-1.0	-1.5	-0.4
Prospective memory result	0.1	0.2	0.4	-0.6	0.7	0.0	-0.0	-0.4	0.3
Lung cancer (father)	1.0	1.2	3.0	-1.7	1.1	-0.1	-0.5	-1.0	-1.2
Illnesses of mother	0.4	0.5	1.4	0.8	0.9	-0.4	0.3	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.1	-0.7	-1.0	-1.8	-1.1	-1.3	-1.7
Pulse wave Arterial Stiffness index	0.6	0.7	2.9	1.7	1.0	-0.0	0.4	-0.1	-0.0
Impedance of arm (left)	0.1	0.6	1.7	0.9	0.7	1.3	0.1	-0.1	-0.8
Arm fat mass (right)	0.2	0.7	3.1	0.5	1.8	0.4	-0.4	-0.4	0.4
Trunk predicted mass	0.1	0.4	0.8	-0.3	0.6	-0.6	0.7	0.9	-0.8
Standing height	0.1	1.4	5.7	-0.7	1.4	-0.6	-0.0	-0.1	-2.4
Length of working week for main job	0.7	0.8	3.0	-1.7	-0.0	0.5	-0.0	0.0	1.2
Exposure to tobacco smoke at home	0.5	0.5	1.3	0.2	0.3	0.7	1.2	1.0	0.4
Breastfed as a baby	0.5	0.6	1.5	-0.1	-1.1	-1.2	-0.8	-0.5	0.1
Tense / ‘highly strung’	0.3	0.5	1.6	0.1	-0.1	0.7	0.9	1.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.2	0.9	-0.2	-1.1	-0.2	-0.3	-0.2
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	1.3	-0.7	0.1	1.5	1.2	0.6
Birth weight of first child	0.5	0.8	3.4	-0.1	-0.3	-1.9	0.3	-0.1	-1.2
Peak expiratory flow (PEF)	0.3	0.8	1.4	0.1	0.3	-1.0	-1.2	-1.1	-1.0
Pulse wave reflection index	0.3	0.4	1.2	0.8	0.7	-0.4	-0.3	-1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.6	-0.9	0.0	-0.3	0.2	1.0
Loud music exposure frequency	0.9	1.0	1.9	-1.4	-1.3	-0.9	-1.1	-0.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.3	-0.4	0.6	1.5	0.0	0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.2	0.8	-0.7	-0.5	-0.6	-1.1
Blood clot in the leg (DVT)	0.5	0.7	2.5	-1.6	-0.6	-0.7	0.3	0.4	-0.8
Medication: Paracetamol	0.5	0.7	2.3	0.4	-1.5	-0.9	0.2	-0.4	1.0
Headache pain in last month	0.2	0.4	1.5	0.5	-0.7	-0.2	0.3	0.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.6	0.1	-0.3	0.3	0.4	-0.8
Glaucoma (self-reported)	0.5	0.5	2.1	-0.1	1.5	-0.2	-0.4	-0.6	-0.7
Gout (self-reported)	0.1	0.2	0.6	0.1	-0.4	0.2	0.8	0.5	0.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.0	-1.0	0.2	-1.5	-1.7	-2.2	-0.6
Medication: Amlodipine	0.9	1.3	2.9	0.2	1.5	1.7	1.2	0.8	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	0.3	0.5	0.8	1.6	1.4	0.1
Birth weight	0.2	0.4	1.3	-0.0	1.1	-0.1	0.3	0.1	-1.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.7	-1.1	0.5	0.8	-1.3	-1.0	-0.7
High blood pressure (siblings)	0.3	0.5	1.1	-0.7	0.6	-0.4	-1.0	-0.8	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.0	6.0	-0.6	-0.8	-2.2	-0.2	-0.5	-2.4
Body fat percentage	0.3	1.2	4.0	0.8	2.0	0.7	-0.6	-0.9	0.9
Leg fat percentage (right)	0.3	0.9	2.5	1.0	0.9	0.4	-0.5	-0.9	1.6
Arm fat-free mass (right)	0.1	0.4	0.9	-0.9	0.7	-0.7	0.4	0.5	-0.3
Exposure to tobacco smoke outside home	0.9	1.2	2.6	0.5	-1.0	0.4	1.1	1.4	1.6
Comparative body size at age 10	0.4	1.0	2.0	0.2	0.8	-1.0	-1.4	-1.4	-0.8
Number of full brothers	0.6	0.8	1.3	-0.4	-0.4	-0.9	-1.1	-1.1	1.0
Worry too long after embarrassment	0.1	0.2	0.8	0.1	-0.9	0.1	-0.3	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	1.2	0.4	-0.5	-0.0	0.1	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	2.9	-0.2	0.6	1.6	1.7	1.4	0.2
Number of children fathered	1.9	2.2	7.3	-2.7	1.0	-0.9	-1.0	-1.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	1.3	-0.3	-1.2	-0.4	-0.4	-1.2
Age at first live birth	0.5	0.9	1.7	1.3	-0.7	-0.0	-1.3	-0.7	0.9
Pulse wave peak to peak time	0.6	0.7	3.0	-1.7	-1.2	0.2	-0.1	0.4	-0.1
Health satisfaction	0.1	0.1	0.3	-0.2	0.4	-0.6	-0.3	0.0	0.2
Shortness of breath walking on level ground	0.0	0.0	0.2	-0.1	0.1	-0.2	-0.1	-0.2	0.4
Qualifications: College or University degree	0.4	1.3	4.4	-0.8	0.2	-1.0	-1.1	-0.8	-2.1
Eye problems/disorders: None of the above	0.6	0.7	3.2	1.8	0.8	0.5	-0.2	-0.1	0.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	7.8	2.8	1.3	1.2	-0.2	-0.1	1.5
Emphysema/chronic bronchitis	0.8	0.9	2.5	-0.1	1.2	1.6	0.7	0.8	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.6	-0.2	0.6	0.2	0.6	-0.7
Neck or shoulder pain in last month	0.8	1.2	4.2	0.6	-0.5	0.5	-1.2	-0.6	2.0
Medication: Blood pressure	0.2	0.4	0.9	0.7	0.6	0.9	-0.2	-0.3	0.9
Angina (self-reported)	0.9	1.2	2.4	1.6	-0.9	1.2	0.9	0.5	1.1
Migraine (self-reported)	0.1	0.1	0.4	-0.6	-0.3	0.0	-0.4	-0.0	-0.4
Medication: Ibuprofen	0.2	0.3	0.9	-0.1	-0.9	-0.4	-0.0	0.0	0.7
Medication: Allopurinol	0.9	1.2	3.5	1.9	-1.0	0.3	1.0	0.9	0.9
Medication: Omeprazole	0.2	0.2	0.4	0.7	0.1	0.3	-0.4	-0.4	0.5
Medication: Seretide 50 evohaler	1.2	1.4	4.0	-0.6	-0.3	1.1	2.0	1.6	0.1
Mean time to correctly identify matches	0.7	1.4	4.1	0.3	-2.0	-0.5	-0.3	-0.2	1.9
Heart disease (mother)	0.3	0.3	1.7	1.3	-0.1	-0.1	0.1	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.2	-0.9	-0.7	-0.7	-0.6	0.1
Whole body fat mass	0.2	1.0	4.3	0.6	2.1	0.4	-0.4	-0.6	0.6
Leg fat mass (right)	0.2	0.7	1.8	0.9	1.4	0.2	-0.2	-0.3	1.1
Arm predicted mass (right)	0.1	0.4	0.7	-0.8	0.5	-0.6	0.6	0.7	-0.5
Pulse rate, automated reading	0.0	0.2	0.3	0.2	0.5	0.5	0.6	0.3	0.1
Alcohol intake frequency.	0.6	1.4	4.5	-0.4	0.2	1.8	-0.7	-0.5	2.1
Comparative height size at age 10	0.2	1.0	4.2	0.2	2.1	0.0	0.2	0.1	-1.3
Number of full sisters	0.8	1.0	3.4	1.9	-0.4	0.7	-0.5	0.2	1.3
Suffer from ‘nerves’	0.3	0.5	1.5	-0.6	0.7	0.3	-0.4	-0.6	-1.2
Overall health rating	0.4	0.8	2.7	0.2	0.7	0.6	-0.8	-0.6	1.7
Chest pain or discomfort	1.1	1.6	2.7	-1.1	-0.7	1.5	1.6	1.5	0.9
Had major operations	4.9	5.8	12.9	3.6	-1.3	1.4	2.6	2.5	2.2
Age at last live birth	0.5	0.7	2.2	1.5	-0.5	-0.6	0.5	0.5	1.0
Family relationship satisfaction	0.3	0.4	0.7	0.4	-0.0	-0.8	-0.8	-0.6	-0.6
Leg pain on walking	0.4	0.4	1.0	-0.4	-1.0	-0.6	1.0	0.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.5	-0.3	0.2	0.1	-0.4	0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	1.1	0.5	0.1	0.7	0.7	-1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	6.2	0.1	-2.5	-0.3	0.9	0.9	-0.3
Medication: Aspirin	0.6	0.8	2.6	0.9	1.6	0.9	-0.4	-0.7	0.3
Supplements: Vitamin C	0.6	0.7	2.3	-0.9	0.6	-0.4	-0.5	-0.7	-1.5
Knee pain experienced in last month	0.1	0.2	0.4	0.1	0.5	0.7	0.1	0.5	0.4
Hypertension (Self-reported)	0.2	0.6	1.4	-0.3	0.1	-1.2	-0.5	-0.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.8	-0.3	1.2	-0.9	0.6	0.2	-1.7
Illnesses of father: Heart disease	2.3	3.3	9.5	1.2	-3.1	-0.4	0.0	0.6	2.9
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.7	1.0	1.1	-0.3	0.2	-0.5
Smoking status: Previous	0.7	1.0	1.9	1.3	-1.0	-0.3	1.0	1.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.5	-0.3	0.5	-1.1	-0.2	0.3	-2.1
Whole body fat-free mass	0.1	0.5	1.3	-0.1	1.1	-0.5	0.7	0.8	-0.6
Leg fat-free mass (right)	0.2	1.0	4.1	0.0	2.0	-0.3	0.7	0.8	-0.9
Arm fat percentage (left)	0.2	0.9	3.4	0.6	1.8	0.9	-0.4	-0.5	0.6
Average weekly red wine intake	0.9	1.3	3.1	0.8	-0.1	1.4	1.8	1.4	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.2	-0.6	0.1	0.7	0.7	-0.6
Mood swings	1.1	1.9	5.3	0.1	0.3	0.3	-2.3	-1.7	1.8
Loneliness, isolation	0.1	0.2	0.4	-0.2	-0.0	0.5	-0.4	-0.1	0.7
Long-standing illness, disability or infirmity	1.4	2.1	4.7	-0.6	0.6	-1.4	-1.7	-2.2	-1.5
Ever had bowel cancer screening	0.8	0.9	2.6	-1.6	0.8	-0.4	-0.3	-0.7	-1.3
Diabetes diagnosed by doctor	0.3	0.5	2.1	-0.6	-1.4	-0.4	0.2	0.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	6.8	0.1	-2.6	-1.0	0.0	0.1	0.7
Friendships satisfaction	0.3	0.4	0.9	-0.9	0.7	0.8	0.1	0.4	0.1
Qualifications: nursing, teaching	1.1	1.7	4.0	-2.0	1.6	0.0	-0.9	-0.9	-1.3
Commuting to job workplace: Walk	0.8	0.9	1.9	-0.6	-1.4	-0.4	-0.8	-0.5	1.4
Eye problems/disorders: Cataract	0.7	0.8	2.2	-1.5	-1.0	0.6	0.4	0.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.8	-0.8	0.1	-1.1	-1.3	-1.3	-0.7
Medication for cholesterol	0.6	1.0	2.7	0.3	-0.6	0.7	1.5	1.6	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.9	5.8	13.0	-1.8	1.8	-1.6	-3.3	-3.6	-1.1
Back pain experienced in last month	0.4	0.6	1.7	-1.3	-1.2	-0.7	-0.2	0.0	0.3
Mineral and other dietary supplements	1.9	2.5	4.9	1.7	-2.2	1.3	1.4	1.6	1.1
Breast cancer (self-reported)	0.5	0.6	1.4	-1.1	-0.7	0.2	-0.5	-0.1	1.2
Asthma (self-reported)	1.3	2.6	4.2	-1.2	2.0	1.7	2.1	1.6	-0.9
Osteoporosis (self-reported)	1.7	2.1	4.3	1.8	2.1	2.1	-0.3	0.1	0.9
Osteoarthritis (self-reported)	0.7	0.9	2.0	-1.4	1.1	-0.3	-0.8	-1.0	-0.9
Medication: Aspirin	0.7	0.9	3.3	0.5	1.8	1.3	-0.2	-0.5	0.5
Medication: Gliclazide	1.2	1.3	3.5	0.2	-1.6	1.0	0.7	0.5	1.9
Illnesses of father: None of the above (group 1)	1.0	1.2	3.0	-1.3	1.7	1.1	0.4	-0.3	-1.1
Smoking status: Current	0.3	0.5	0.7	0.4	0.4	0.8	0.8	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	3.5	-1.2	-0.7	-1.9	-1.0	-1.7	-1.6
Whole body water mass	0.1	0.5	1.1	-0.3	1.1	-0.6	0.5	0.7	-0.7
Leg predicted mass (right)	0.2	1.0	4.0	0.0	2.0	-0.3	0.6	0.8	-0.9
Arm fat mass (left)	0.2	0.7	3.3	0.6	1.8	0.4	-0.5	-0.4	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.8	-0.2	0.9	0.0	-0.1	-0.1	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	1.0	0.4	-0.9	0.6	-0.2	0.2	1.0
Miserableness	0.6	1.0	1.9	1.1	0.5	0.1	-1.4	-1.4	1.0
Guilty feelings	1.2	1.8	2.9	1.7	1.1	1.2	1.6	1.7	0.3
Wears glasses or contact lenses	1.0	1.1	2.6	0.5	-1.6	1.0	1.1	1.2	0.5
Ever taken oral contraceptive pill	1.0	1.1	4.8	-0.4	-2.2	-0.5	0.6	0.7	0.6
Hearing aid user	0.3	0.4	1.0	0.6	-0.5	-0.0	0.6	0.5	1.0
Mother’s age at death	0.1	0.2	0.3	-0.4	0.6	-0.1	0.0	-0.4	-0.6
Financial situation satisfaction	1.3	1.6	4.9	1.5	-0.3	1.2	0.5	0.6	2.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	1.3	-0.7	-0.3	0.3	0.2	1.3
Commuting to job workplace: Public transport	1.0	1.1	2.6	-0.9	1.6	1.1	1.0	0.9	-0.7
Eye problems/disorders: Glaucoma	1.2	1.4	2.7	-1.1	1.0	-1.0	-1.3	-1.6	-0.9
Medication: Blood pressure	1.2	2.3	3.0	-1.6	-0.0	-1.7	-1.6	-1.7	-1.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.0	-1.7	1.2	0.9	-0.0	0.1	-0.4
Supplements: Fish oil (including cod liver oil)	2.0	2.6	6.5	-1.8	2.5	-0.9	-1.3	-1.5	-1.2
High cholesterol (Self-reported)	0.8	1.4	3.1	0.2	1.2	-0.9	-1.8	-1.5	-0.6
Medication: Bendroflumethiazide	0.8	1.2	3.4	0.4	0.8	-1.8	-0.8	-1.1	-1.2
Medication: Paracetamol	0.3	0.5	1.4	0.4	-1.2	-0.1	0.6	0.2	0.9
Medication: Lisinopril	0.0	0.1	0.1	-0.1	0.2	0.3	0.3	0.4	-0.1
Medication: Atorvastatin	0.9	1.1	3.7	-1.9	1.1	1.0	-0.3	-0.7	0.2
Illnesses of father: High blood pressure	1.3	1.7	3.9	-0.3	-2.0	-1.8	-1.4	-0.9	-0.2
Alcohol drinker status: Never	0.5	0.6	1.3	1.1	0.5	-0.3	-1.0	-1.1	0.0
Ever smoked	0.7	1.2	3.7	0.1	-0.9	0.4	1.7	1.9	0.2
Basal metabolic rate	0.1	0.5	1.6	0.1	1.3	-0.4	0.5	0.7	-0.5
Leg fat percentage (left)	0.3	1.1	2.1	0.7	1.5	0.3	-0.8	-1.2	1.4
Arm fat-free mass (left)	0.1	0.3	1.0	-0.7	1.0	-0.4	0.3	0.4	-0.4
Number of operations (self-reported)	1.4	2.0	2.9	1.7	-1.5	0.2	1.4	1.4	1.7
Average weekly beer plus cider intake	1.1	1.6	4.0	0.4	1.3	1.3	2.0	1.5	0.3
Irritability	0.4	0.6	2.6	0.9	-0.2	-0.1	-0.2	0.5	1.6
Risk taking	0.8	1.2	1.6	1.2	-1.0	1.0	1.3	1.0	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-0.5	0.0	1.2	0.6	0.9	0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.6	-0.7	-0.8	0.7	0.6	0.5	-0.0
Age started oral contraceptive pill	0.1	0.2	0.6	0.8	-0.1	0.1	0.2	0.4	0.4
Diastolic blood pressure, automated reading	0.5	1.5	2.5	-0.8	0.4	1.4	1.6	1.3	1.4
Ever depressed for a whole week	0.3	0.3	1.1	0.2	0.4	-0.1	-1.0	-0.8	0.2
Unable to work because of sickness or disability	0.7	0.9	2.3	0.2	-1.3	-1.5	0.6	0.4	-0.8
Commuting to job workplace: Cycle	0.5	0.7	1.3	0.1	1.0	0.8	1.0	1.1	-0.0
Myopia	1.7	2.4	11.1	3.3	0.8	-0.2	0.4	0.1	-1.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.4	0.3	-0.2	1.1	0.9	1.2	1.1
Cholesterol lowering medication	2.4	3.6	9.3	-0.8	1.7	-1.0	-2.7	-3.0	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	1.6	1.2	-0.5	-0.7	-0.8	-0.7
Pain experienced in last month	0.3	0.5	1.4	0.4	1.2	0.3	-0.4	-0.7	-1.0
Supplements: Calcium	0.3	0.3	0.7	-0.3	-0.3	-0.9	-0.4	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	0.1	-0.7	-1.1	-0.6	-1.0	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.6	1.6	-0.2	0.1	-0.3	-0.5	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.8	-1.9	-0.5	-0.8	0.2	0.2	-1.1
Heart disease (siblings)	0.3	0.3	0.6	0.3	-0.4	-0.0	0.7	0.7	-0.7
Alcohol drinker status: Previous	1.0	1.1	2.5	-0.9	1.0	0.7	-1.4	-1.6	-0.2
Pack years of smoking	1.1	1.6	6.7	0.6	2.6	1.5	-0.4	-0.2	0.5
Impedance of whole body	0.0	0.2	0.7	0.5	-0.2	0.8	-0.3	-0.6	-0.0
Leg fat mass (left)	0.2	0.8	2.6	0.7	1.6	0.3	-0.3	-0.5	1.0
Arm predicted mass (left)	0.1	0.3	1.2	-0.1	1.1	-0.4	0.3	0.5	-0.2