TWAS hub - SERPINE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.075	0.0300	4.6e-03	0.007	0.021	0.019	0.024	0.01	3.9e-02	1.1e-03	1.9e-03	0.00051	1.8e-02
2	TCGA	Brain Lower Grade Glioma	0.081	0.0343	3.5e-05	0.047	0.047	0.048	NA	0.05	4.2e-06	4.5e-06	3.7e-06	NA	2.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hayfever/allergic rhinitis (self-reported)	5.0	6.6	6.8	-2.6	-2.6
Neck or shoulder pain in last month	4.9	6.9	8.8	2.3	3.0
Illnesses of mother	4.3	5.3	8.0	1.6	2.8
HDL Cholesterol	4.1	6.9	9.0	-3.0	-2.2
Depression (self-reported)	3.7	4.4	5.7	-2.4	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	5.0	-2.2	-1.8
Medication: Lisinopril	3.4	4.5	5.7	-2.4	-1.8
Leg fat percentage (left)	3.3	12.0	18.1	2.4	4.3
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	6.7	-1.0	-2.6
Illnesses of father: Heart disease	3.0	4.2	6.5	-2.5	-1.4
Leg fat percentage (right)	2.9	10.5	15.3	2.4	3.9
Crohns Disease (2017)	2.8	6.2	6.3	2.5	2.5
Rheumatoid Arthritis	2.8	3.8	6.0	2.5	1.3
Smoking Status	2.8	6.7	8.9	2.1	3.0
Crohns Disease (2012)	2.7	4.3	5.0	2.2	1.9
Blood Red Count	2.7	25.9	32.8	5.7	4.3
Age at last live birth	2.4	3.5	5.5	-1.3	-2.3
Eye problems/disorders: Cataract	2.4	2.8	3.6	1.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	3.7	-1.4	-1.9
Risk taking	2.4	3.5	5.2	1.3	2.3
Ovarian Cancer	2.3	3.0	3.2	1.8	1.7
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	5.7	-1.3	-2.4
Smoking status: Current	2.3	3.7	5.8	1.3	2.4
Past tobacco smoking	2.2	4.0	4.6	-2.1	-1.8
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	3.9	2.0	1.2
Age at first live birth	2.2	4.0	7.4	-0.7	-2.7
Had major operations	2.2	2.5	3.1	1.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	5.7	-1.8	-2.4
Wears glasses or contact lenses	2.2	2.5	3.8	1.9	1.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	6.0	0.8	2.5
Medication: Seretide 50 evohaler	2.1	2.4	3.3	1.2	1.8
Ever taken oral contraceptive pill	2.1	2.4	2.4	1.6	1.5
Illnesses of siblings: Diabetes	1.9	2.3	2.5	1.4	1.6
Leg fat mass (left)	1.9	7.4	11.2	1.9	3.3
Lupus	1.8	2.8	4.8	0.8	2.2
BMI	1.8	10.2	13.5	2.6	3.7
Angina	1.8	2.4	3.3	1.8	1.2
Current tobacco smoking	1.8	2.9	4.7	1.0	2.2
Waist circumference	1.8	6.7	9.0	2.1	3.0
Body fat percentage	1.8	7.2	9.3	2.3	3.1
Angina (self-reported)	1.8	2.4	3.4	1.9	1.1
Leg fat mass (right)	1.8	7.0	10.3	1.9	3.2
Pulse rate, automated reading	1.8	5.9	10.6	1.1	3.3
Arm fat percentage (left)	1.8	7.3	9.7	2.2	3.1
Heel T-Score	1.7	13.8	15.1	-3.5	-3.9
Diabetes (father)	1.7	2.1	2.5	1.3	1.6
Severe depression (siblings)	1.7	1.9	3.5	0.6	-1.9
Supplements: Glucosamine	1.7	2.3	2.9	1.3	1.7
Body mass index (BMI)	1.7	7.5	12.2	1.6	3.5
Smoking status: Previous	1.7	2.6	3.6	1.9	1.3
Breast cancer (self-reported)	1.7	2.0	3.3	-0.9	-1.8
Medication: Metformin	1.6	2.2	3.1	1.1	1.8
Commuting to job workplace: Walk	1.6	1.8	3.1	-0.6	1.8
Coronary Artery Disease (CAD)	1.5	1.8	3.5	-1.9	-0.3
Fasting Glucose	1.5	1.8	3.2	-0.7	-1.8
Medication: Co-codamol	1.5	1.8	2.0	1.4	1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.4	0.4	1.9
Cholesterol lowering medication	1.5	2.3	3.8	0.8	1.9
Average weekly spirits intake	1.4	1.7	3.4	0.1	1.8
Sensitivity / hurt feelings	1.4	2.4	3.2	-1.8	-1.3
High blood pressure (mother)	1.4	1.9	2.2	-1.5	-1.3
Arm fat percentage (right)	1.4	5.4	7.6	1.8	2.8
Medication: Lansoprazole	1.4	1.6	2.7	-1.6	-0.7
Shortness of breath walking on level ground	1.4	1.6	3.2	-1.8	0.1
Osteoarthritis (self-reported)	1.4	1.8	2.6	1.1	1.6
Number of operations (self-reported)	1.4	2.0	2.4	1.5	1.3
Forced vital capacity (FVC)	1.3	5.2	6.5	-2.0	-2.6
Mouth/teeth dental problems	1.3	2.0	3.1	0.9	1.8
Hip circumference	1.3	5.6	8.2	1.7	2.9
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	5.1	-1.9	-2.2
Prospective memory result	1.3	1.6	3.1	-1.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	4.5	-1.9	-2.1
Forced vital capacity (FVC), Best measure	1.3	4.6	5.7	-1.9	-2.4
Comparative height size at age 10	1.3	7.1	8.0	-2.5	-2.8
Average weekly fortified wine intake	1.2	1.5	2.9	0.0	-1.7
Time employed in main current job	1.2	1.3	1.6	1.0	1.3
Happiness	1.2	1.4	1.8	1.0	1.3
Medication: Cholesterol lowering	1.2	1.9	3.7	-1.9	-0.4
Number of children fathered	1.2	1.3	1.6	1.3	1.0
Whole body fat mass	1.2	5.1	6.9	1.9	2.6
Qualifications: nursing, teaching	1.2	1.8	2.8	1.7	0.9
Medication: Atorvastatin	1.2	1.5	1.6	1.2	1.3
Maternal smoking around birth	1.1	1.7	1.9	1.4	1.2
Standing height	1.1	11.4	19.0	-1.9	-4.4
Medication: Ventolin 100micrograms inhaler	1.1	1.4	1.6	-1.1	-1.3
Health satisfaction	1.1	1.4	1.5	1.2	1.2
Qualifications: College or University degree	1.1	3.6	3.7	-1.9	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.5	0.9	1.2
Arm fat mass (left)	1.1	4.4	6.7	1.5	2.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.3	0.3	-1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.1	-0.5	-1.5
Trunk fat percentage	1.0	4.2	4.6	1.9	2.2
Impedance of arm (right)	1.0	4.8	9.3	-0.5	-3.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-0.2	-1.8
Eye problems/disorders: None of the above	1.0	1.2	2.2	-1.5	-0.3
Illnesses of father: None of the above (group 1)	1.0	1.3	1.6	1.0	1.3
Hearing aid user	1.0	1.1	1.3	0.9	1.1
High cholesterol (Self-reported)	1.0	1.7	3.3	-1.8	-0.4
Medication: Bendroflumethiazide	1.0	1.4	2.5	-1.6	-0.6
Heart disease (siblings)	1.0	1.2	1.2	-1.1	-1.1
Stomach or abdominal pain in last month	0.9	1.2	1.8	0.7	-1.3
Alcohol usually taken with meals	0.9	1.5	2.7	-0.6	-1.6
Financial difficulties in last 2 years	0.9	1.2	2.0	1.4	0.6
Arm fat mass (right)	0.9	3.6	5.5	1.3	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.6	-1.6	-0.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.6	-0.7	-1.3
Overall health rating	0.9	1.9	3.1	0.9	1.8
Back pain experienced in last month	0.9	1.3	1.4	1.2	1.1
Fractured/broken bones in last 5 years	0.9	1.1	1.4	0.9	1.2
Systolic Blood Pressure	0.8	4.2	4.5	-2.0	-2.1
Hand grip strength (right)	0.8	2.3	2.9	-1.7	-1.3
Taking other prescription medications	0.8	1.3	1.8	0.9	1.3
Trunk fat mass	0.8	3.5	4.2	1.6	2.1
Exposure to tobacco smoke at home	0.8	0.9	1.5	0.6	1.2
Medication: Amlodipine	0.8	1.1	2.1	-0.2	1.4
Heart disease (mother)	0.8	0.9	1.3	-1.2	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	1.2	-1.1	-1.0
Ever smoked	0.8	1.5	1.5	1.2	1.2
Bipolar Disorder (2018)	0.7	1.2	2.0	-1.4	-0.6
Irritable Bowel Disease (IBD)	0.7	1.7	2.0	1.2	1.4
Major Depression (MDD)	0.7	0.9	1.7	0.0	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.6	0.6	1.3
Multivitamins +/- minerals	0.7	0.8	1.5	-0.5	-1.2
Medication: Ramipril	0.7	0.9	0.9	-1.0	0.9
Falls in the last year	0.7	0.9	1.4	0.6	1.2
Number of live births	0.7	1.1	1.4	0.8	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.2	-0.2	-1.8
Pulse wave Arterial Stiffness index	0.7	0.8	0.9	0.9	-0.9
Impedance of arm (left)	0.7	3.3	6.6	0.2	-2.6
Peak expiratory flow (PEF)	0.7	1.6	3.1	-0.4	-1.8
Comparative body size at age 10	0.7	2.0	3.7	0.5	1.9
Pulse wave peak to peak time	0.7	0.9	1.4	-1.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	0.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	0.4	1.2
Long-standing illness, disability or infirmity	0.7	1.0	1.0	1.0	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	0.6	1.2
Irritability	0.7	1.2	1.6	-0.9	-1.3
Prostate Cancer	0.6	0.8	1.6	-0.2	1.3
Age at First Birth	0.6	0.9	1.0	-1.0	-0.9
Height	0.6	11.8	19.5	-2.0	-4.4
Number of treatments/medications taken	0.6	1.1	2.2	-1.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	-0.7	-1.4
Medication: Atenolol	0.6	0.8	1.1	1.0	0.6
Fluid intelligence score	0.6	1.3	1.5	1.2	1.0
Medication: Allopurinol	0.6	0.8	1.5	0.1	1.2
Mean time to correctly identify matches	0.6	1.1	2.0	-1.4	-0.4
Family relationship satisfaction	0.6	0.7	1.3	0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-1.1	-0.2
Average weekly red wine intake	0.6	0.9	1.1	-1.0	-0.9
Pain experienced in last month	0.6	0.9	1.8	-1.4	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	1.1	-0.4
Body Mass Index (BMI) (2010)	0.5	0.6	0.8	0.7	0.9
LDL Cholesterol	0.5	0.7	1.2	0.5	-1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.0	1.0	0.9
Age when periods started (menarche)	0.5	1.1	1.7	-0.8	-1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.5	0.7	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	0.6	0.9
Tense / ‘highly strung’	0.5	0.8	1.5	-1.2	-0.0
Hair/balding pattern: Pattern 4	0.5	1.3	1.8	1.4	0.9
Pulse wave reflection index	0.5	0.6	1.1	0.3	-1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	1.2	0.3
Gout (self-reported)	0.5	0.7	1.1	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	1.0	0.4
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.1	0.2
Knee pain experienced in last month	0.5	0.7	1.1	-0.6	-1.1
Loneliness, isolation	0.5	0.7	1.3	0.3	1.1
Financial situation satisfaction	0.5	0.6	1.3	-1.1	0.2
Ever depressed for a whole week	0.5	0.7	1.0	1.0	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.5	1.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	0.9	0.6
Alzheimer’s Disease (in father)	0.4	0.4	0.4	0.7	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	0.6	0.7	-0.8
Blood Platelet Count	0.4	4.1	8.3	0.1	2.9
Allergy or Eczema	0.4	1.1	2.0	-0.5	-1.4
Respiratory disease	0.4	0.9	1.0	1.0	0.8
Lung FVC	0.4	2.1	3.6	-1.9	-0.8
Hand grip strength (left)	0.4	1.2	1.3	-1.0	-1.1
Systolic blood pressure, automated reading	0.4	1.0	1.0	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	0.0	-1.0
High blood pressure	0.4	1.1	2.2	-1.5	0.1
Medication: Levothyroxine sodium	0.4	0.6	1.3	-0.1	1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-1.1	-0.2
Diabetes (self-reported)	0.4	0.7	0.9	0.9	0.7
Father’s age at death	0.4	0.5	0.8	-0.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	1.1	0.3
Pulse rate	0.4	0.8	1.5	0.0	1.2
Number of full brothers	0.4	0.5	0.9	-0.2	0.9
Worry too long after embarrassment	0.4	0.7	1.3	-1.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	0.2
Suffer from ‘nerves’	0.4	0.6	1.2	-0.1	1.1
Leg pain on walking	0.4	0.5	0.9	1.0	-0.2
Osteoporosis (self-reported)	0.4	0.5	0.6	0.5	0.8
Guilty feelings	0.4	0.6	1.2	-1.1	-0.1
Mother’s age at death	0.4	0.5	0.6	0.7	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.7	-0.8	-0.5
Impedance of whole body	0.4	1.8	3.5	0.3	-1.9
Worry (Nagel 2018)	0.3	0.7	0.8	0.9	0.7
Breast Cancer	0.3	0.8	1.5	-0.2	-1.2
Primary Biliary Cirrhosis	0.3	0.5	1.0	0.2	-1.0
Blood White Count	0.3	2.1	3.9	0.6	2.0
Waist Hip Ratio (WHR)	0.3	1.5	2.9	1.7	-0.2
Cardiovascular Disease	0.3	1.0	1.6	-1.3	-0.6
Hypothyroidism (self reported)	0.3	0.7	1.3	-1.2	0.3
Hair Pigment	0.3	7.5	9.7	-2.3	-3.1
Pack years adult smoking proportion	0.3	0.5	0.9	-0.2	1.0
Sitting height	0.3	2.2	4.4	0.3	-2.1
Number of incorrect matches in round	0.3	0.5	0.7	0.8	0.5
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.6	-0.7
Had other major operations	0.3	0.4	0.7	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	-0.3	-1.0
Qualifications: None of the above	0.3	0.5	1.0	-1.0	0.3
Medication: Simvastatin	0.3	0.4	0.7	-0.8	0.4
Weight	0.3	1.5	2.4	0.8	1.5
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-1.0	-0.4
Migraine (self-reported)	0.3	0.3	0.5	-0.7	0.4
Medication: Ibuprofen	0.3	0.3	0.5	0.3	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.5	0.7	0.5
Hypertension (Self-reported)	0.3	0.9	1.7	-1.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.8	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	-0.5	0.6
Friendships satisfaction	0.3	0.3	0.5	0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-1.1	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.8	-0.2
Myopia	0.3	0.5	0.5	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	0.4	0.7	0.5
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.3
HbA1C	0.2	0.2	0.4	-0.6	0.0
Neuroticism (2016)	0.2	0.3	0.5	-0.0	0.7
Ulcerative Colitis	0.2	0.3	0.6	0.2	0.8
Tanning	0.2	3.0	6.0	2.4	0.2
Relative age of first facial hair	0.2	0.3	0.6	-0.3	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.3	0.6
Supplements: Zinc	0.2	0.2	0.4	-0.1	-0.6
Impedance of leg (right)	0.2	0.9	1.9	0.0	-1.4
Fed-up feelings	0.2	0.4	0.7	-0.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.2	0.6
Nervous feelings	0.2	0.4	0.7	-0.8	-0.4
Heart attack	0.2	0.3	0.5	0.7	0.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.5	-0.2
Birth weight of first child	0.2	0.4	0.7	-0.2	-0.8
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.2
High blood pressure (siblings)	0.2	0.3	0.5	0.2	-0.7
Medication: Blood pressure	0.2	0.4	0.9	-0.9	0.0
Alcohol intake frequency.	0.2	0.5	0.6	0.8	0.6
Chest pain or discomfort	0.2	0.3	0.6	-0.1	0.7
Medication for cholesterol	0.2	0.2	0.5	-0.0	-0.7
Medication: Gliclazide	0.2	0.2	0.3	-0.4	0.5
Medication: Blood pressure	0.2	0.3	0.5	-0.4	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.2	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.0	0.4	1.0
Commuting to job workplace: Cycle	0.2	0.2	0.2	0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.2	-0.4	-0.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.4	-0.6
Pack years of smoking	0.2	0.3	0.5	-0.4	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.8	0.2
Schizophrenia (2018)	0.1	0.3	0.6	0.1	0.8
Reaction Time	0.1	0.2	0.5	-0.1	0.7
Mean Putamen Volume	0.1	0.1	0.2	-0.2	-0.4
Schizophrenia (2014)	0.1	0.2	0.3	-0.4	0.6
Triglycerides	0.1	0.1	0.2	0.4	-0.0
Blood Eosinophil Count	0.1	0.5	1.0	-0.1	1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.2	0.6
Medication for hormone replacement therapy	0.1	0.1	0.1	0.1	-0.4
Vitamin and mineral supplements	0.1	0.1	0.1	-0.3	0.4
Diabetes (mother)	0.1	0.1	0.3	0.5	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.4	0.2
Relative age voice broke	0.1	0.1	0.2	0.5	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.4	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.2	-0.5	-0.3
Allergy	0.1	0.1	0.2	-0.2	0.5
Pain all over the body in last month	0.1	0.1	0.1	-0.4	0.3
Illnesses of siblings	0.1	0.2	0.4	0.0	0.6
Neuroticism score	0.1	0.2	0.5	-0.7	-0.0
Trunk fat-free mass	0.1	0.4	0.7	-0.9	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.1	-0.3	-0.3
Worrier / anxious feelings	0.1	0.3	0.5	0.7	0.2
Noisy workplace	0.1	0.2	0.3	0.2	-0.6
Lung cancer (father)	0.1	0.2	0.3	-0.5	0.2
Trunk predicted mass	0.1	0.5	0.8	-0.9	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.1	0.5
Headache pain in last month	0.1	0.1	0.3	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.1	0.6
Arm fat-free mass (right)	0.1	0.3	0.6	-0.2	0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.4	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	0.4	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.4	0.2
Medication: Omeprazole	0.1	0.1	0.2	-0.1	-0.5
Arm predicted mass (right)	0.1	0.5	1.1	0.2	1.0
Medication: Aspirin	0.1	0.1	0.2	-0.4	-0.3
Ever had bowel cancer screening	0.1	0.1	0.2	0.3	0.4
Mineral and other dietary supplements	0.1	0.2	0.3	-0.6	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.5	0.4
Miserableness	0.1	0.2	0.4	0.1	0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	-0.3	-0.3
Medication: Paracetamol	0.1	0.2	0.3	-0.2	0.6
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.6	-0.1
Alcohol drinker status: Never	0.1	0.2	0.2	0.5	-0.3
Age started oral contraceptive pill	0.1	0.1	0.3	0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	0.3	0.5
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.2	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.1	0.0
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.6	0.4
Neuroticism	0.0	0.1	0.1	0.1	0.3
Chronotype (morning person)	0.0	0.1	0.2	-0.1	0.4
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.0	0.4
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.2	0.1
Leg fat-free mass (left)	0.0	0.0	0.0	0.1	0.1
Impedance of leg (left)	0.0	0.2	0.4	0.2	-0.6
Leg predicted mass (left)	0.0	0.0	0.0	0.1	0.0
Had menopause	0.0	0.0	0.0	-0.1	-0.1
Asthma	0.0	0.0	0.0	-0.2	0.1
Length of working week for main job	0.0	0.0	0.0	0.2	-0.2
Breastfed as a baby	0.0	0.0	0.0	-0.2	-0.2
Medication: Paracetamol	0.0	0.1	0.1	-0.2	0.3
Glaucoma (self-reported)	0.0	0.1	0.1	-0.3	0.1
Birth weight	0.0	0.1	0.1	0.2	0.2
Number of full sisters	0.0	0.0	0.0	-0.2	0.1
Supplements: Vitamin C	0.0	0.0	0.0	0.1	0.1
Whole body fat-free mass	0.0	0.1	0.3	-0.5	-0.1
Leg fat-free mass (right)	0.0	0.0	0.1	0.1	0.3
Mood swings	0.0	0.1	0.1	0.3	0.3
Diabetes diagnosed by doctor	0.0	0.1	0.1	0.1	0.3
Asthma (self-reported)	0.0	0.1	0.1	-0.3	-0.0
Medication: Aspirin	0.0	0.0	0.1	-0.3	-0.1
Whole body water mass	0.0	0.1	0.2	-0.5	-0.1
Leg predicted mass (right)	0.0	0.0	0.0	-0.0	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.1	0.2
Basal metabolic rate	0.0	0.1	0.1	-0.2	0.3
Arm fat-free mass (left)	0.0	0.2	0.2	-0.5	0.4
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	0.1
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.3	0.1
Supplements: Calcium	0.0	0.1	0.1	-0.2	-0.3
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.2	0.1
Arm predicted mass (left)	0.0	0.1	0.2	-0.4	0.4

Hub : Genes

SERPINE1

Models

Trait associations