TWAS hub - SERTAD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1550	0.0520	2.0e-04	0.014	NA	0.013	NA	0.006	2.6e-02	NA	3.4e-02	NA	1.0e-01
2	NTR	Blood	0.0267	0.0107	1.9e-03	0.001	0.007	0.005	0.008	0.001	2.0e-01	1.4e-03	5.1e-03	0.00067	1.6e-01
3	TCGA	Thyroid Carcinoma	0.1440	0.0500	7.7e-09	0.118	0.100	0.101	NA	0.110	1.6e-11	6.2e-10	4.6e-10	NA	7.6e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Atorvastatin	7.7	9.5	17.1	-4.1	-2.3	-2.5
Current tobacco smoking	7.0	11.4	14.9	-3.9	-3.0	-3.2
Smoking status: Current	6.8	10.8	14.0	-3.7	-3.0	-3.0
Smoking Status	6.4	15.2	22.7	-4.8	-0.9	-4.7
Number of treatments/medications taken	6.2	11.2	24.1	-4.9	-2.3	-2.1
Myopia	6.0	8.7	12.7	3.6	-2.0	3.1
Medication: Aspirin	5.9	7.7	20.0	-4.5	-0.3	-1.8
Medication: Gliclazide	5.8	6.5	12.0	-3.5	-0.5	-2.7
Medication: Lansoprazole	5.0	5.7	9.6	-3.1	-0.0	-2.8
Medication for cholesterol, blood pressure or diabetes	4.9	8.1	18.3	4.3	1.0	2.2
Cardiovascular Disease	4.5	15.0	28.5	-5.3	-0.5	-4.0
Financial situation satisfaction	4.5	5.6	6.8	1.9	2.5	2.6
Alzheimer’s Disease (in father)	4.4	4.8	9.0	2.3	0.5	3.0
Medication: Aspirin	4.4	5.7	15.1	-3.9	0.1	-1.4
Medication: Cholesterol lowering	4.3	6.7	13.9	-3.7	-0.2	-2.5
Medication: Ramipril	4.1	5.3	11.4	-3.4	-1.4	-1.6
Angina (self-reported)	4.1	5.4	10.3	-3.2	1.6	-1.8
Angina	4.0	5.3	10.8	-3.3	1.5	-1.7
Leg fat percentage (left)	4.0	14.4	24.5	-4.2	4.9	-1.0
Medication for pain relief, constipation, heartburn	3.9	6.7	12.6	3.5	2.3	1.5
Smoking status: Previous	3.9	5.8	8.9	-1.6	3.0	-2.4
Average weekly red wine intake	3.9	5.8	8.5	-2.6	-1.5	-2.9
Ever smoked	3.9	6.9	12.4	-2.8	0.7	-3.5
Diabetes (father)	3.7	4.5	5.0	-2.0	2.2	-2.2
Medication: Blood pressure	3.7	6.5	13.8	-3.7	-1.6	-1.7
Medication: Omeprazole	3.6	4.3	6.4	-2.5	-1.5	-2.0
Commuting to job workplace: Car/motor vehicle	3.6	4.1	11.6	-0.5	3.4	0.7
Leg fat mass (left)	3.6	13.9	26.3	-3.9	5.1	-0.4
Supplements: Zinc	3.5	3.8	7.9	2.8	1.0	1.6
Leg fat percentage (right)	3.5	12.6	20.8	-4.0	4.6	-0.9
Past tobacco smoking	3.4	6.2	11.6	2.2	-1.5	3.4
Wheeze or whistling in the chest in last year	3.4	6.0	11.2	-2.1	1.5	-3.4
Leg fat mass (right)	3.4	13.0	25.1	-3.7	5.0	-0.3
Hypertension (Self-reported)	3.4	9.3	15.8	-4.0	-1.5	-3.1
Mineral and other dietary supplements	3.4	4.5	6.8	-2.4	-1.1	-2.6
Alzheimer’s Disease (including proxy)	3.3	4.7	9.2	2.0	1.0	3.0
High blood pressure (mother)	3.3	4.7	7.5	-2.0	-1.6	-2.7
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	4.2	2.0	-2.0	1.8
High cholesterol (Self-reported)	3.3	5.8	9.7	-3.1	-0.1	-2.8
Medication: Omeprazole (e.g. Zanprol)	3.3	4.1	8.1	-2.9	-1.0	-1.8
Knee pain experienced in last month	3.2	4.9	7.2	-2.7	2.0	-1.9
Taking other prescription medications	3.1	4.8	11.0	-3.3	-0.9	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	5.5	-2.3	-0.9	-2.1
Medication: Co-codamol	3.0	3.5	8.4	-2.9	-0.2	-1.4
Number of self-reported non-cancer illnesses	3.0	5.3	9.5	-3.1	0.3	-2.5
Number of children fathered	2.9	3.3	6.1	-2.5	1.2	-1.6
Happiness	2.8	3.4	4.0	2.0	1.8	1.7
Body fat percentage	2.8	10.9	17.6	-3.9	4.2	0.2
Whole body fat mass	2.8	11.6	20.2	-3.8	4.5	0.1
Vascular/heart problems diagnosed by doctor	2.8	7.6	15.7	4.0	0.8	2.5
Guilty feelings	2.7	4.1	5.0	2.2	1.6	2.2
Reaction Time	2.6	5.0	11.7	3.4	-1.4	1.1
Age at First Birth	2.6	3.8	9.0	1.4	0.6	3.0
High blood pressure	2.6	7.3	12.6	-3.5	-1.2	-2.8
Trunk fat mass	2.6	11.3	18.7	-3.9	4.3	0.2
Number of full brothers	2.6	3.3	8.4	-1.2	2.9	0.4
Emphysema/chronic bronchitis	2.6	2.9	4.8	-2.2	0.3	-1.9
Waist circumference	2.5	9.3	17.8	-3.0	4.2	1.1
Mouth/teeth dental problems	2.5	3.9	6.7	2.2	-0.5	2.6
Breast Cancer	2.4	5.9	9.6	3.1	0.4	2.8
HDL Cholesterol	2.4	4.0	5.4	1.7	2.0	2.3
Medication: Metformin	2.4	3.4	5.7	-2.4	-0.2	-2.1
Chronic bronchitis/emphysema (father)	2.4	2.8	7.7	-0.8	2.8	-0.4
Hip circumference	2.4	10.1	21.9	-0.1	4.7	2.9
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	8.4	-0.8	-2.9	-0.0
Medication: Ibuprofen	2.4	2.9	8.5	-0.3	-2.9	0.1
Number of full sisters	2.4	2.9	4.4	-2.1	1.1	-1.8
Supplements: Fish oil (including cod liver oil)	2.4	3.2	5.2	1.5	1.4	2.3
Loud music exposure frequency	2.3	2.5	6.6	-0.9	-2.6	-0.2
Pain experienced in last month	2.3	3.8	6.8	2.6	-1.0	1.9
Trunk fat percentage	2.2	9.0	13.8	-3.7	3.6	0.5
Age when periods started (menarche)	2.2	5.4	10.5	-3.2	-0.7	-2.3
Medication: Amlodipine	2.2	3.0	5.5	-2.3	-0.3	-1.9
Arm fat mass (left)	2.2	9.0	17.8	-2.8	4.2	1.1
Bipolar Disorder (2011)	2.1	2.0	6.0	2.4	0.1	0.0
Multivitamins +/- minerals	2.1	2.7	4.8	1.8	0.2	2.2
Arm fat mass (right)	2.1	8.8	17.4	-2.8	4.2	1.0
Medication: Seretide 50 evohaler	2.1	2.4	3.4	-1.7	-1.8	-0.9
Supplements: Vitamin C	2.1	2.5	4.5	1.6	0.6	2.1
Illnesses of father: Heart disease	2.1	3.0	6.7	-2.6	0.7	-1.3
Cholesterol lowering medication	2.1	3.1	4.4	-2.1	1.2	-1.8
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	2.6	-1.6	1.1	-1.6
Mouth/teeth dental problems: Dentures	2.0	3.3	7.6	-1.3	-0.8	-2.8
Had major operations	2.0	2.4	5.2	-2.3	-0.8	-1.1
BMI	1.9	11.2	26.9	-2.3	5.2	1.2
Impedance of leg (right)	1.9	9.1	15.7	-2.8	-2.0	-4.0
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	3.5	-1.9	-0.7	-1.6
Body mass index (BMI)	1.9	8.2	18.7	-2.1	4.3	1.2
Impedance of leg (left)	1.9	9.3	16.9	-3.0	-1.5	-4.1
Medication: Simvastatin	1.9	2.8	4.9	-1.5	2.2	-1.1
Weight	1.9	9.5	19.6	-2.9	4.4	0.5
Arm fat percentage (right)	1.9	7.4	13.1	-2.6	3.6	1.5
Pulse wave Arterial Stiffness index	1.9	2.2	3.9	-2.0	-1.5	-0.7
Gout (self-reported)	1.9	2.6	5.9	-2.4	0.0	-1.4
Frequency of depressed mood in last 2 weeks	1.8	2.5	5.7	-0.6	2.4	-1.2
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	5.2	-0.5	2.3	-0.9
Medication: Levothyroxine sodium	1.8	3.1	4.7	-1.1	1.8	-2.2
Alcohol usually taken with meals	1.8	2.9	4.4	-2.1	-1.8	-1.0
Arm fat percentage (left)	1.8	7.3	12.9	-2.6	3.6	1.4
Mother’s age at death	1.8	2.3	3.0	1.7	-1.1	1.7
Age started oral contraceptive pill	1.8	2.3	3.4	1.9	-0.0	1.8
Waist Hip Ratio (WHR)	1.7	7.7	19.2	-4.4	-0.1	-2.0
Hearing difficulty/problems: Yes	1.7	2.7	5.7	1.4	2.4	0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.1	6.2	-2.5	-0.4	-0.3
Heel T-Score	1.6	13.1	39.1	0.4	0.4	-6.2
Stomach or abdominal pain in last month	1.6	2.0	3.3	-1.8	0.9	-1.4
Supplements: Glucosamine	1.6	2.1	4.0	0.7	2.0	1.4
Medication: Paracetamol	1.6	2.6	4.5	-1.8	-2.1	-0.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	6.9	-0.9	1.3	-2.6
Mouth/teeth dental problems: Loose teeth	1.6	1.8	5.2	-0.1	-2.3	-0.6
Migraine (self-reported)	1.6	2.0	4.9	-1.0	-2.2	-0.5
Age at last live birth	1.6	2.4	2.8	1.7	1.3	1.7
Long-standing illness, disability or infirmity	1.6	2.4	5.4	-2.3	1.2	-0.6
Supplements: Calcium	1.6	1.8	2.8	1.7	-0.8	1.4
Coronary Artery Disease (CAD)	1.5	1.8	2.6	-0.8	1.5	-1.6
Crohns Disease (2012)	1.5	2.3	3.2	-1.1	-1.6	-1.8
Systolic Blood Pressure	1.5	7.4	12.5	-3.5	-0.5	-3.1
Vitamin and mineral supplements	1.5	2.0	4.0	-1.4	-0.1	-2.0
Diabetes (mother)	1.5	1.9	3.0	1.4	0.8	1.7
Hand grip strength (right)	1.5	4.0	5.5	-1.5	2.3	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.9	-0.8	2.0	-1.2
Number of incorrect matches in round	1.5	2.6	4.8	-0.5	2.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	7.3	-1.1	2.7	-1.1
Commuting to job workplace: Public transport	1.5	1.8	3.7	0.0	-1.9	1.3
Arm predicted mass (left)	1.5	7.9	19.3	-2.0	4.4	-0.4
Mean Putamen Volume	1.4	1.6	2.4	1.3	-0.9	1.6
Headache pain in last month	1.4	2.3	3.5	-1.9	-1.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.2	0.2	2.0	-1.0
Arm fat-free mass (left)	1.4	7.0	16.7	-2.0	4.1	-0.5
Heart disease (siblings)	1.4	1.7	3.5	-1.9	0.0	-1.3
HbA1C	1.3	1.4	4.2	0.0	2.0	-0.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.8	0.5	2.0	0.9
Heart attack	1.3	1.6	4.6	-2.1	-0.5	-0.3
Depression (self-reported)	1.3	1.5	3.7	-0.9	0.2	-1.9
Length of working week for main job	1.3	1.4	3.4	-1.9	-0.9	-0.3
Age at first live birth	1.3	2.4	4.4	2.1	0.2	1.7
Pulse wave peak to peak time	1.3	1.6	2.5	1.4	1.6	0.4
Health satisfaction	1.3	1.8	3.3	1.8	-0.1	1.4
Qualifications: College or University degree	1.3	4.0	10.8	0.8	-3.3	0.7
Arm predicted mass (right)	1.3	6.7	17.1	-1.7	4.1	-0.3
Friendships satisfaction	1.3	1.6	2.8	0.9	1.7	1.0
Medication: Blood pressure	1.3	2.5	4.6	-1.3	-2.1	-1.1
Triglycerides	1.2	1.9	2.9	-1.7	-0.5	-1.6
Average weekly fortified wine intake	1.2	1.4	4.2	0.1	-2.0	-0.0
Medication: Atenolol	1.2	1.6	2.1	-1.4	-1.1	-1.1
Hearing difficulty/problems with background noise	1.2	2.0	3.5	1.5	1.9	0.2
Lung cancer (father)	1.2	1.4	2.5	-1.2	-0.0	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	2.8	-0.3	1.7	-1.5
Hair/balding pattern: Pattern 4	1.2	3.0	5.2	2.3	-1.9	0.5
Glaucoma (self-reported)	1.2	1.4	2.4	1.0	1.5	0.9
Worry too long after embarrassment	1.2	1.9	5.4	2.3	-0.6	-0.1
Mean time to correctly identify matches	1.2	2.2	5.3	2.3	-1.0	0.6
Leg pain on walking	1.2	1.4	2.8	-1.7	0.6	-1.1
Unable to work because of sickness or disability	1.2	1.6	2.9	-1.7	-0.5	-1.3
Rheumatoid Arthritis	1.1	1.5	3.3	-0.8	-1.8	-0.6
Hypothyroidism (self reported)	1.1	2.6	5.3	-1.3	0.9	-2.3
Neuroticism	1.1	2.6	6.0	2.5	1.0	0.9
Fed-up feelings	1.1	2.0	3.0	-1.7	1.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.6	-0.2	1.2	-1.9
Fluid intelligence score	1.1	2.4	3.6	0.4	-1.9	1.8
Father’s age at death	1.1	1.5	4.3	0.0	2.1	0.4
Impedance of arm (left)	1.1	4.9	14.4	0.0	-3.8	0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	1.6	-1.1	0.4
Arm fat-free mass (right)	1.1	5.6	15.2	-1.3	3.9	-0.2
Overall health rating	1.1	2.4	3.7	-1.9	1.0	-1.6
Medication: Lisinopril	1.1	1.4	3.9	-2.0	0.2	-0.6
Basal metabolic rate	1.1	5.9	15.4	-1.4	3.9	0.5
Commuting to job workplace: Cycle	1.1	1.4	3.8	1.9	-0.5	0.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.5	1.0	-0.7	2.4
Blood White Count	1.0	7.0	14.1	-3.8	-0.8	-2.5
Hand grip strength (left)	1.0	2.7	5.0	-1.4	2.2	-1.0
Average weekly spirits intake	1.0	1.3	3.2	-1.8	-0.1	0.8
Ever had hysterectomy (womb removed)	1.0	1.1	1.9	-1.4	-1.1	-0.6
Pack years adult smoking proportion	1.0	1.5	2.2	-1.5	-1.4	-0.7
Diabetes (self-reported)	1.0	1.5	2.8	-1.7	-0.7	-1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.9	2.0	-0.0	0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	6.8	-0.9	1.5	-2.6
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.5	1.3	-2.1	0.5
Illnesses of mother	1.0	1.3	3.3	-0.3	1.8	0.6
Family relationship satisfaction	1.0	1.2	2.1	-1.4	1.1	-0.6
Medication for cholesterol	1.0	1.5	2.6	1.6	0.3	1.3
Impedance of whole body	1.0	4.9	9.5	-1.4	-3.1	-1.7
Depression (Nagel 2018)	0.9	1.4	3.3	-0.4	1.8	-0.8
Ovarian Cancer	0.9	1.2	3.0	-0.8	1.7	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.2	-1.0	0.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.8	-1.9	1.0	-0.4
Lung FVC	0.9	4.7	12.6	0.3	1.2	-3.5
Chronotype (morning person)	0.9	2.0	4.4	0.4	-1.2	2.1
Hair/balding pattern: Pattern 2	0.9	1.1	2.0	-1.0	1.4	-0.6
Impedance of arm (right)	0.9	4.2	12.5	-0.1	-3.5	0.3
Time employed in main current job	0.9	1.0	2.9	-1.7	0.1	-0.3
Worrier / anxious feelings	0.9	1.8	4.9	2.2	-0.3	0.6
Exposure to tobacco smoke outside home	0.9	1.2	3.2	0.5	1.8	-0.1
Medication: Allopurinol	0.9	1.2	2.8	-1.7	-0.2	-0.8
Leg fat-free mass (right)	0.9	4.7	11.1	-0.2	3.3	1.7
Diabetes diagnosed by doctor	0.9	1.5	2.9	-1.7	-0.0	-1.2
Qualifications: nursing, teaching	0.9	1.5	4.3	0.0	-2.1	-0.3
Osteoporosis (self-reported)	0.9	1.1	3.1	0.1	-0.4	1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	1.4	-1.1	0.3
Ever taken oral contraceptive pill	0.9	1.0	2.4	0.7	1.6	-0.3
Alcohol drinker status: Never	0.9	1.1	2.4	0.9	-1.5	-0.2
Number of operations (self-reported)	0.9	1.3	3.1	-1.8	-0.1	-0.9
Average weekly beer plus cider intake	0.9	1.2	3.2	-0.1	1.8	0.7
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.2	0.4	-0.9	2.5
Crohns Disease (2017)	0.8	1.8	3.5	-0.5	-1.9	-1.3
Leg fat-free mass (left)	0.8	4.5	11.1	-0.7	3.3	1.4
Maternal smoking around birth	0.8	1.1	3.0	-0.5	0.4	-1.7
Serious illness, injury or assault to yourself	0.8	1.0	1.7	-1.3	-0.7	-0.9
Leg predicted mass (left)	0.8	4.3	10.9	-0.6	3.3	1.4
Forced vital capacity (FVC)	0.8	3.0	6.9	-0.8	1.3	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.5	-0.8	1.3	-2.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.5	0.5	1.0	1.2
Birth weight	0.8	1.7	3.7	0.8	1.9	1.0
Whole body fat-free mass	0.8	4.6	12.5	-1.0	3.5	0.4
Whole body water mass	0.8	4.6	12.7	-1.1	3.6	0.3
Leg predicted mass (right)	0.8	4.4	10.5	-0.2	3.2	1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.9	-1.7	0.2	-0.4
Irritability	0.8	1.3	3.5	1.9	-0.4	0.6
Fractured/broken bones in last 5 years	0.8	1.1	2.1	-1.4	-0.5	-1.0
Pack years of smoking	0.8	1.2	2.1	-1.4	-1.0	-0.7
Worry (Nagel 2018)	0.7	1.5	2.2	1.5	1.4	-0.3
Fasting Glucose	0.7	0.8	2.5	0.1	-1.6	-0.0
Height	0.7	13.9	24.8	-5.0	2.0	-3.6
Nervous feelings	0.7	1.3	2.2	1.5	1.2	-0.2
Neuroticism score	0.7	1.4	3.9	2.0	0.2	0.4
Trunk fat-free mass	0.7	4.2	11.8	-0.9	3.4	0.1
Falls in the last year	0.7	1.0	2.5	0.6	1.6	0.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.1	1.5	-0.5	0.9
Noisy workplace	0.7	0.8	1.0	1.0	1.0	0.7
Trunk predicted mass	0.7	4.3	11.7	-1.1	3.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	-0.4	1.5	-0.7
Forced vital capacity (FVC), Best measure	0.7	2.7	5.1	-0.6	1.6	-2.3
Comparative body size at age 10	0.7	1.8	3.0	1.3	1.7	0.9
Medication: Paracetamol	0.7	1.1	2.7	-0.8	-1.6	-0.1
Ever depressed for a whole week	0.7	0.9	2.3	0.5	-1.5	-0.3
Basal cell carcinoma (self-reported)	0.7	0.9	1.5	-0.5	-1.2	-0.9
Alcohol drinker status: Previous	0.7	0.7	1.9	-0.6	-0.0	-1.4
Neuroticism (Nagel 2018)	0.6	1.3	2.4	1.6	1.2	0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	0.5	-0.3	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.6	1.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.2	1.4	0.0	-1.5
Allergy	0.6	1.3	2.2	0.0	-1.5	1.3
Prospective memory result	0.6	0.7	1.5	0.7	-0.5	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	1.2	-0.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	0.1	-1.1	1.0
Pulse rate, automated reading	0.6	1.9	2.9	-1.7	-1.7	0.1
Suffer from ‘nerves’	0.6	1.0	2.2	0.0	1.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	1.3	-0.5	0.4
Average weekly champagne plus white wine intake	0.6	0.9	2.2	0.7	-1.5	0.1
Blood Red Count	0.5	5.1	9.2	-3.0	2.2	-1.1
Allergy or Eczema	0.5	1.2	1.7	1.2	1.3	-0.8
Respiratory disease	0.5	1.0	2.0	0.2	1.4	-1.0
Sensitivity / hurt feelings	0.5	0.8	1.2	1.1	0.3	-1.0
Relative age of first facial hair	0.5	1.1	3.0	-1.7	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	0.5	-0.2	-1.8
Financial difficulties in last 2 years	0.5	0.7	1.8	0.2	1.4	0.5
Pulse rate	0.5	0.8	1.5	-0.1	-1.0	1.2
Asthma	0.5	1.0	2.6	0.4	1.6	-0.4
Peak expiratory flow (PEF)	0.5	1.2	2.2	-0.9	0.7	-1.5
Eye problems/disorders: None of the above	0.5	0.6	1.5	-0.5	-1.2	-0.4
Comparative height size at age 10	0.5	2.7	5.1	-1.7	0.4	-2.3
Ever had bowel cancer screening	0.5	0.6	1.2	-1.1	-0.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.2	-0.6	0.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.0	1.7	0.2	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	0.5	0.9	0.8
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	-0.7	-1.0	-0.3
Ulcerative Colitis	0.4	0.6	0.7	0.8	0.6	0.8
Tanning	0.4	4.4	6.2	-1.3	2.3	-2.5
Qualifications: CSEs or equivalent	0.4	0.6	0.8	0.5	0.9	0.9
Qualifications: None of the above	0.4	0.9	2.0	-0.9	1.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.5	-1.2	-0.5
High blood pressure (siblings)	0.4	0.6	1.4	1.2	-0.6	-0.1
Loneliness, isolation	0.4	0.6	1.6	-0.4	1.3	0.1
Commuting to job workplace: Walk	0.4	0.5	0.8	0.7	-0.9	0.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	0.8	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.6	0.4	-0.7	-0.8
Back pain experienced in last month	0.4	0.5	0.9	-0.9	0.8	0.2
Asthma (self-reported)	0.4	0.8	1.9	0.4	1.4	-0.6
Miserableness	0.4	0.8	2.0	0.1	0.5	-1.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.7	-0.6	-0.7	-0.8
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	1.3	0.1	-0.6
Prostate Cancer	0.3	0.4	0.9	0.1	-1.0	0.3
Systolic blood pressure, automated reading	0.3	0.9	2.7	-1.6	0.3	-0.1
Severe depression (siblings)	0.3	0.3	0.6	-0.6	-0.1	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.3	1.1	0.1
Relative age voice broke	0.3	0.5	0.9	-0.6	-0.9	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	1.2	0.2	-0.7
Had menopause	0.3	0.4	0.6	0.4	-0.8	0.7
Had other major operations	0.3	0.3	0.6	-0.5	0.8	0.4
Pain all over the body in last month	0.3	0.3	0.7	-0.8	0.3	-0.2
Illnesses of siblings	0.3	0.4	0.7	0.8	0.6	0.5
Standing height	0.3	2.7	4.8	-2.2	0.8	-1.6
Breastfed as a baby	0.3	0.4	0.6	0.6	-0.8	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.8	0.8	-0.2
Neck or shoulder pain in last month	0.3	0.4	1.1	-1.0	-0.3	-0.4
Heart disease (mother)	0.3	0.3	0.6	-0.8	-0.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-0.4	1.0	-0.4
Breast cancer (self-reported)	0.3	0.3	0.7	-0.5	-0.0	0.9
Osteoarthritis (self-reported)	0.3	0.3	1.0	0.0	-1.0	-0.1
Hearing aid user	0.3	0.4	0.5	-0.6	0.7	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.5	0.9	0.3
Medication: Bendroflumethiazide	0.3	0.5	0.7	-0.8	-0.8	-0.1
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.1	-0.7	-0.9
Risk taking	0.3	0.4	1.3	-1.1	0.1	0.2
Bipolar Disorder (2018)	0.2	0.4	1.0	1.0	-0.2	-0.3
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.1	0.9	-0.5
Schizophrenia (2018)	0.2	0.4	0.7	0.9	0.3	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	-0.4	-0.9	-0.7
LDL Cholesterol	0.2	0.3	0.4	-0.7	-0.1	-0.7
Neuroticism (2016)	0.2	0.3	0.4	0.7	-0.4	-0.4
Sitting height	0.2	1.2	2.3	0.4	1.5	-1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.7	-0.5	0.4
Number of live births	0.2	0.2	0.4	-0.5	0.6	0.1
Tense / ‘highly strung’	0.2	0.3	0.6	0.1	-0.5	-0.8
Pulse wave reflection index	0.2	0.3	0.5	-0.1	-0.7	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.4	-0.7	0.6	-0.3
Alcohol intake frequency.	0.2	0.5	0.8	0.8	0.4	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.4	-0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.0	0.4	0.7
Wears glasses or contact lenses	0.2	0.2	0.4	-0.2	-0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.0	0.8	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.3	0.5	0.5
Lupus	0.1	0.2	0.3	-0.5	-0.2	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.3	-0.5	-0.1
Schizophrenia (2014)	0.1	0.3	0.4	0.5	0.7	-0.4
Blood Eosinophil Count	0.1	0.4	0.8	-0.4	0.9	-0.5
Lung FEV1/FVC ratio	0.1	0.6	1.0	-0.7	0.3	-1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.2	0.6	-0.1
Medication for hormone replacement therapy	0.1	0.1	0.1	0.3	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	-0.7	-0.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.4	-0.2	-0.4
Birth weight of first child	0.1	0.3	0.5	0.0	0.6	0.7
Chest pain or discomfort	0.1	0.1	0.2	-0.5	0.3	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.3	-0.3	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.4	0.8	0.4
Major Depression (MDD)	0.0	0.0	0.1	0.3	0.0	-0.1
Blood Platelet Count	0.0	0.3	0.4	-0.5	-0.6	-0.5
Hair Pigment	0.0	0.4	0.7	-0.4	0.9	0.6
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.4	0.1	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	-0.2	0.2
Shortness of breath walking on level ground	0.0	0.0	0.1	-0.3	-0.1	-0.1
Mood swings	0.0	0.1	0.2	0.0	-0.1	-0.5

Hub : Genes

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Trait associations