Hub : Genes

SERTAD4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.1550 0.0520 2.0e-04 0.014 NA 0.013 NA 0.006 2.6e-02 NA 3.4e-02 NA 1.0e-01
2 NTR Blood 0.0267 0.0107 1.9e-03 0.001 0.007 0.005 0.008 0.001 2.0e-01 1.4e-03 5.1e-03 0.00067 1.6e-01
3 TCGA Thyroid Carcinoma 0.1440 0.0500 7.7e-09 0.118 0.100 0.101 NA 0.110 1.6e-11 6.2e-10 4.6e-10 NA 7.6e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 1.0 1.0 -0.2 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 1.7 1.3 0.1 -0.6
Depressed Affect (Nagel 2018) 0.2 0.3 0.7 -0.1 0.9 -0.5
Depression (Nagel 2018) 0.9 1.4 3.3 -0.4 1.8 -0.8
Intelligence (Savage-Jansen 2018) 0.8 2.4 6.2 0.4 -0.9 2.5
Neuroticism (Nagel 2018) 0.6 1.3 2.4 1.6 1.2 0.1
Schizophrenia (2018) 0.2 0.4 0.7 0.9 0.3 -0.6
Schizophrenia vs Biploar Disorder 0.4 0.6 1.0 -0.7 -1.0 -0.3
Worry (Nagel 2018) 0.7 1.5 2.2 1.5 1.4 -0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.8 0.5 -0.3 1.3
Alzheimer’s Disease (in father) 4.4 4.8 9.0 2.3 0.5 3.0
Alzheimer’s Disease (including proxy) 3.3 4.7 9.2 2.0 1.0 3.0
Crohns Disease (2017) 0.8 1.8 3.5 -0.5 -1.9 -1.3
Irritable Bowel Disease (IBD) 0.2 0.5 0.8 -0.4 -0.9 -0.7
Ulcerative Colitis (UC) 0.1 0.2 0.3 0.3 0.5 0.5
Major Depression (MDD) 0.0 0.0 0.1 0.3 0.0 -0.1
Reaction Time 2.6 5.0 11.7 3.4 -1.4 1.1
Verbal and Numeric Reasoning (VNR) 1.0 2.4 5.5 1.0 -0.7 2.4
Breast Cancer 2.4 5.9 9.6 3.1 0.4 2.8
Ovarian Cancer 0.9 1.2 3.0 -0.8 1.7 0.3
Prostate Cancer 0.3 0.4 0.9 0.1 -1.0 0.3
Age at First Birth 2.6 3.8 9.0 1.4 0.6 3.0
Bipolar Disorder (2011) 2.1 2.0 6.0 2.4 0.1 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 -0.6 1.3 -0.5
Coronary Artery Disease (CAD) 1.5 1.8 2.6 -0.8 1.5 -1.6
Crohns Disease (2012) 1.5 2.3 3.2 -1.1 -1.6 -1.8
Mean Putamen Volume 1.4 1.6 2.4 1.3 -0.9 1.6
Fasting Glucose 0.7 0.8 2.5 0.1 -1.6 -0.0
HbA1C 1.3 1.4 4.2 0.0 2.0 -0.1
HDL Cholesterol 2.4 4.0 5.4 1.7 2.0 2.3
LDL Cholesterol 0.2 0.3 0.4 -0.7 -0.1 -0.7
Lupus 0.1 0.2 0.3 -0.5 -0.2 -0.5
Neuroticism (2016) 0.2 0.3 0.4 0.7 -0.4 -0.4
Primary Biliary Cirrhosis 0.1 0.1 0.3 0.3 -0.5 -0.1
Rheumatoid Arthritis 1.1 1.5 3.3 -0.8 -1.8 -0.6
Schizophrenia (2014) 0.1 0.3 0.4 0.5 0.7 -0.4
Triglycerides 1.2 1.9 2.9 -1.7 -0.5 -1.6
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.2 -1.0 0.8 -1.1
Ulcerative Colitis 0.4 0.6 0.7 0.8 0.6 0.8
Blood Eosinophil Count 0.1 0.4 0.8 -0.4 0.9 -0.5
Blood Platelet Count 0.0 0.3 0.4 -0.5 -0.6 -0.5
Blood Red Count 0.5 5.1 9.2 -3.0 2.2 -1.1
Blood White Count 1.0 7.0 14.1 -3.8 -0.8 -2.5
Heel T-Score 1.6 13.1 39.1 0.4 0.4 -6.2
BMI 1.9 11.2 26.9 -2.3 5.2 1.2
Height 0.7 13.9 24.8 -5.0 2.0 -3.6
Waist Hip Ratio (WHR) 1.7 7.7 19.2 -4.4 -0.1 -2.0
Systolic Blood Pressure 1.5 7.4 12.5 -3.5 -0.5 -3.1
Smoking Status 6.4 15.2 22.7 -4.8 -0.9 -4.7
Allergy or Eczema 0.5 1.2 1.7 1.2 1.3 -0.8
Cardiovascular Disease 4.5 15.0 28.5 -5.3 -0.5 -4.0
Hypothyroidism (self reported) 1.1 2.6 5.3 -1.3 0.9 -2.3
Respiratory disease 0.5 1.0 2.0 0.2 1.4 -1.0
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.8 -1.9 1.0 -0.4
Lung FEV1/FVC ratio 0.1 0.6 1.0 -0.7 0.3 -1.0
Lung FVC 0.9 4.7 12.6 0.3 1.2 -3.5
Neuroticism 1.1 2.6 6.0 2.5 1.0 0.9
Chronotype (morning person) 0.9 2.0 4.4 0.4 -1.2 2.1
Hair Pigment 0.0 0.4 0.7 -0.4 0.9 0.6
Tanning 0.4 4.4 6.2 -1.3 2.3 -2.5
Hand grip strength (left) 1.0 2.7 5.0 -1.4 2.2 -1.0
Number of treatments/medications taken 6.2 11.2 24.1 -4.9 -2.3 -2.1
Average weekly spirits intake 1.0 1.3 3.2 -1.8 -0.1 0.8
Sensitivity / hurt feelings 0.5 0.8 1.2 1.1 0.3 -1.0
Frequency of depressed mood in last 2 weeks 1.8 2.5 5.7 -0.6 2.4 -1.2
Hearing difficulty/problems: Yes 1.7 2.7 5.7 1.4 2.4 0.5
Relative age of first facial hair 0.5 1.1 3.0 -1.7 -0.3 -0.3
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 3.8 0.5 2.0 0.9
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.1 -0.4 0.1 -0.1
Ever had hysterectomy (womb removed) 1.0 1.1 1.9 -1.4 -1.1 -0.6
Systolic blood pressure, automated reading 0.3 0.9 2.7 -1.6 0.3 -0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.2 0.6 -0.1
Angina 4.0 5.3 10.8 -3.3 1.5 -1.7
Medication for hormone replacement therapy 0.1 0.1 0.1 0.3 -0.1 0.3
Vitamin and mineral supplements 1.5 2.0 4.0 -1.4 -0.1 -2.0
Supplements: Zinc 3.5 3.8 7.9 2.8 1.0 1.6
Medication: Co-codamol 3.0 3.5 8.4 -2.9 -0.2 -1.4
Medication: Metformin 2.4 3.4 5.7 -2.4 -0.2 -2.1
Diabetes (father) 3.7 4.5 5.0 -2.0 2.2 -2.2
Diabetes (mother) 1.5 1.9 3.0 1.4 0.8 1.7
Severe depression (siblings) 0.3 0.3 0.6 -0.6 -0.1 -0.8
Pack years adult smoking proportion 1.0 1.5 2.2 -1.5 -1.4 -0.7
Impedance of leg (right) 1.9 9.1 15.7 -2.8 -2.0 -4.0
Leg fat-free mass (left) 0.8 4.5 11.1 -0.7 3.3 1.4
Trunk fat percentage 2.2 9.0 13.8 -3.7 3.6 0.5
Hand grip strength (right) 1.5 4.0 5.5 -1.5 2.3 -2.1
Townsend deprivation index at recruitment 0.3 0.4 1.1 0.3 1.1 0.1
Current tobacco smoking 7.0 11.4 14.9 -3.9 -3.0 -3.2
Average weekly fortified wine intake 1.2 1.4 4.2 0.1 -2.0 -0.0
Maternal smoking around birth 0.8 1.1 3.0 -0.5 0.4 -1.7
Fed-up feelings 1.1 2.0 3.0 -1.7 1.6 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.9 -0.8 2.0 -1.2
Relative age voice broke 0.3 0.5 0.9 -0.6 -0.9 -0.4
Taking other prescription medications 3.1 4.8 11.0 -3.3 -0.9 -1.7
Age when periods started (menarche) 2.2 5.4 10.5 -3.2 -0.7 -2.3
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 3.5 -1.9 -0.7 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.1 0.5 -0.2 -1.8
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 2.6 -1.6 1.1 -1.6
Qualifications: CSEs or equivalent 0.4 0.6 0.8 0.5 0.9 0.9
Serious illness, injury or assault to yourself 0.8 1.0 1.7 -1.3 -0.7 -0.9
High blood pressure 2.6 7.3 12.6 -3.5 -1.2 -2.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 1.2 0.2 -0.7
Multivitamins +/- minerals 2.1 2.7 4.8 1.8 0.2 2.2
Stomach or abdominal pain in last month 1.6 2.0 3.3 -1.8 0.9 -1.4
Supplements: Glucosamine 1.6 2.1 4.0 0.7 2.0 1.4
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 5.2 -0.5 2.3 -0.9
Medication: Atenolol 1.2 1.6 2.1 -1.4 -1.1 -1.1
Medication: Levothyroxine sodium 1.8 3.1 4.7 -1.1 1.8 -2.2
Sitting height 0.2 1.2 2.3 0.4 1.5 -1.1
Chronic bronchitis/emphysema (father) 2.4 2.8 7.7 -0.8 2.8 -0.4
High blood pressure (mother) 3.3 4.7 7.5 -2.0 -1.6 -2.7
Body mass index (BMI) 1.9 8.2 18.7 -2.1 4.3 1.2
Impedance of leg (left) 1.9 9.3 16.9 -3.0 -1.5 -4.1
Leg predicted mass (left) 0.8 4.3 10.9 -0.6 3.3 1.4
Trunk fat mass 2.6 11.3 18.7 -3.9 4.3 0.2
Waist circumference 2.5 9.3 17.8 -3.0 4.2 1.1
Number of incorrect matches in round 1.5 2.6 4.8 -0.5 2.2 -1.6
Past tobacco smoking 3.4 6.2 11.6 2.2 -1.5 3.4
Alcohol usually taken with meals 1.8 2.9 4.4 -2.1 -1.8 -1.0
Nervous feelings 0.7 1.3 2.2 1.5 1.2 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.6 -0.2 1.2 -1.9
Hearing difficulty/problems with background noise 1.2 2.0 3.5 1.5 1.9 0.2
Hair/balding pattern: Pattern 2 0.9 1.1 2.0 -1.0 1.4 -0.6
Had menopause 0.3 0.4 0.6 0.4 -0.8 0.7
Had other major operations 0.3 0.3 0.6 -0.5 0.8 0.4
Forced vital capacity (FVC) 0.8 3.0 6.9 -0.8 1.3 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.2 1.4 0.0 -1.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.5 -0.7 -0.0 -0.1
Qualifications: None of the above 0.4 0.9 2.0 -0.9 1.4 -0.2
Financial difficulties in last 2 years 0.5 0.7 1.8 0.2 1.4 0.5
Mouth/teeth dental problems 2.5 3.9 6.7 2.2 -0.5 2.6
Heart attack 1.3 1.6 4.6 -2.1 -0.5 -0.3
Allergy 0.6 1.3 2.2 0.0 -1.5 1.3
Pain all over the body in last month 0.3 0.3 0.7 -0.8 0.3 -0.2
Diabetes (self-reported) 1.0 1.5 2.8 -1.7 -0.7 -1.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 3.9 2.0 -0.0 0.5
Medication: Ramipril 4.1 5.3 11.4 -3.4 -1.4 -1.6
Medication: Simvastatin 1.9 2.8 4.9 -1.5 2.2 -1.1
Fluid intelligence score 1.1 2.4 3.6 0.4 -1.9 1.8
Illnesses of siblings 0.3 0.4 0.7 0.8 0.6 0.5
Neuroticism score 0.7 1.4 3.9 2.0 0.2 0.4
Weight 1.9 9.5 19.6 -2.9 4.4 0.5
Impedance of arm (right) 0.9 4.2 12.5 -0.1 -3.5 0.3
Arm fat percentage (right) 1.9 7.4 13.1 -2.6 3.6 1.5
Trunk fat-free mass 0.7 4.2 11.8 -0.9 3.4 0.1
Hip circumference 2.4 10.1 21.9 -0.1 4.7 2.9
Time employed in main current job 0.9 1.0 2.9 -1.7 0.1 -0.3
Alcohol intake versus 10 years previously 0.2 0.3 0.5 0.7 -0.5 0.4
Father’s age at death 1.1 1.5 4.3 0.0 2.1 0.4
Worrier / anxious feelings 0.9 1.8 4.9 2.2 -0.3 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.4 -0.2 -0.4
Falls in the last year 0.7 1.0 2.5 0.6 1.6 0.4
Hair/balding pattern: Pattern 3 0.7 1.1 2.1 1.5 -0.5 0.9
Number of live births 0.2 0.2 0.4 -0.5 0.6 0.1
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 6.8 -0.9 1.5 -2.6
Pulse rate 0.5 0.8 1.5 -0.1 -1.0 1.2
Happiness 2.8 3.4 4.0 2.0 1.8 1.7
Noisy workplace 0.7 0.8 1.0 1.0 1.0 0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.1 4.5 1.3 -2.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 4.2 2.0 -2.0 1.8
Mouth/teeth dental problems: Dentures 2.0 3.3 7.6 -1.3 -0.8 -2.8
Asthma 0.5 1.0 2.6 0.4 1.6 -0.4
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 8.4 -0.8 -2.9 -0.0
Medication: Cholesterol lowering 4.3 6.7 13.9 -3.7 -0.2 -2.5
Depression (self-reported) 1.3 1.5 3.7 -0.9 0.2 -1.9
Medication: Lansoprazole 5.0 5.7 9.6 -3.1 -0.0 -2.8
Prospective memory result 0.6 0.7 1.5 0.7 -0.5 1.2
Lung cancer (father) 1.2 1.4 2.5 -1.2 -0.0 -1.6
Illnesses of mother 1.0 1.3 3.3 -0.3 1.8 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 5.5 -0.8 1.3 -2.3
Pulse wave Arterial Stiffness index 1.9 2.2 3.9 -2.0 -1.5 -0.7
Impedance of arm (left) 1.1 4.9 14.4 0.0 -3.8 0.5
Arm fat mass (right) 2.1 8.8 17.4 -2.8 4.2 1.0
Trunk predicted mass 0.7 4.3 11.7 -1.1 3.4 -0.1
Standing height 0.3 2.7 4.8 -2.2 0.8 -1.6
Length of working week for main job 1.3 1.4 3.4 -1.9 -0.9 -0.3
Exposure to tobacco smoke at home 0.0 0.0 0.0 0.2 -0.2 0.2
Breastfed as a baby 0.3 0.4 0.6 0.6 -0.8 0.3
Tense / ‘highly strung’ 0.2 0.3 0.6 0.1 -0.5 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 2.8 -0.3 1.7 -1.5
Hair/balding pattern: Pattern 4 1.2 3.0 5.2 2.3 -1.9 0.5
Birth weight of first child 0.1 0.3 0.5 0.0 0.6 0.7
Peak expiratory flow (PEF) 0.5 1.2 2.2 -0.9 0.7 -1.5
Pulse wave reflection index 0.2 0.3 0.5 -0.1 -0.7 0.5
Ever highly irritable/argumentative for 2 days 0.8 0.9 1.5 0.5 1.0 1.2
Loud music exposure frequency 2.3 2.5 6.6 -0.9 -2.6 -0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.5 0.5 -1.2 -0.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.2 -0.4 1.5 -0.7
Blood clot in the leg (DVT) 0.2 0.3 0.4 -0.7 0.6 -0.3
Medication: Paracetamol 1.6 2.6 4.5 -1.8 -2.1 -0.6
Headache pain in last month 1.4 2.3 3.5 -1.9 -1.3 -1.3
Medication for cholesterol, blood pressure or diabetes 4.9 8.1 18.3 4.3 1.0 2.2
Glaucoma (self-reported) 1.2 1.4 2.4 1.0 1.5 0.9
Gout (self-reported) 1.9 2.6 5.9 -2.4 0.0 -1.4
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 6.9 -0.9 1.3 -2.6
Medication: Amlodipine 2.2 3.0 5.5 -2.3 -0.3 -1.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 -0.8 0.8 -0.2
Birth weight 0.8 1.7 3.7 0.8 1.9 1.0
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.5 1.6 -1.1 0.4
High blood pressure (siblings) 0.4 0.6 1.4 1.2 -0.6 -0.1
Forced vital capacity (FVC), Best measure 0.7 2.7 5.1 -0.6 1.6 -2.3
Body fat percentage 2.8 10.9 17.6 -3.9 4.2 0.2
Leg fat percentage (right) 3.5 12.6 20.8 -4.0 4.6 -0.9
Arm fat-free mass (right) 1.1 5.6 15.2 -1.3 3.9 -0.2
Exposure to tobacco smoke outside home 0.9 1.2 3.2 0.5 1.8 -0.1
Comparative body size at age 10 0.7 1.8 3.0 1.3 1.7 0.9
Number of full brothers 2.6 3.3 8.4 -1.2 2.9 0.4
Worry too long after embarrassment 1.2 1.9 5.4 2.3 -0.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.2 0.2 2.0 -1.0
Wheeze or whistling in the chest in last year 3.4 6.0 11.2 -2.1 1.5 -3.4
Number of children fathered 2.9 3.3 6.1 -2.5 1.2 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 1.2 -0.0 -0.8
Age at first live birth 1.3 2.4 4.4 2.1 0.2 1.7
Pulse wave peak to peak time 1.3 1.6 2.5 1.4 1.6 0.4
Health satisfaction 1.3 1.8 3.3 1.8 -0.1 1.4
Shortness of breath walking on level ground 0.0 0.0 0.1 -0.3 -0.1 -0.1
Qualifications: College or University degree 1.3 4.0 10.8 0.8 -3.3 0.7
Eye problems/disorders: None of the above 0.5 0.6 1.5 -0.5 -1.2 -0.4
Mouth/teeth dental problems: Loose teeth 1.6 1.8 5.2 -0.1 -2.3 -0.6
Emphysema/chronic bronchitis 2.6 2.9 4.8 -2.2 0.3 -1.9
Medication for pain relief, constipation, heartburn 3.9 6.7 12.6 3.5 2.3 1.5
Neck or shoulder pain in last month 0.3 0.4 1.1 -1.0 -0.3 -0.4
Medication: Blood pressure 3.7 6.5 13.8 -3.7 -1.6 -1.7
Angina (self-reported) 4.1 5.4 10.3 -3.2 1.6 -1.8
Migraine (self-reported) 1.6 2.0 4.9 -1.0 -2.2 -0.5
Medication: Ibuprofen 2.4 2.9 8.5 -0.3 -2.9 0.1
Medication: Allopurinol 0.9 1.2 2.8 -1.7 -0.2 -0.8
Medication: Omeprazole 3.6 4.3 6.4 -2.5 -1.5 -2.0
Medication: Seretide 50 evohaler 2.1 2.4 3.4 -1.7 -1.8 -0.9
Mean time to correctly identify matches 1.2 2.2 5.3 2.3 -1.0 0.6
Heart disease (mother) 0.3 0.3 0.6 -0.8 -0.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.1 0.1 -1.1 1.0
Whole body fat mass 2.8 11.6 20.2 -3.8 4.5 0.1
Leg fat mass (right) 3.4 13.0 25.1 -3.7 5.0 -0.3
Arm predicted mass (right) 1.3 6.7 17.1 -1.7 4.1 -0.3
Pulse rate, automated reading 0.6 1.9 2.9 -1.7 -1.7 0.1
Alcohol intake frequency. 0.2 0.5 0.8 0.8 0.4 0.9
Comparative height size at age 10 0.5 2.7 5.1 -1.7 0.4 -2.3
Number of full sisters 2.4 2.9 4.4 -2.1 1.1 -1.8
Suffer from ‘nerves’ 0.6 1.0 2.2 0.0 1.5 -0.8
Overall health rating 1.1 2.4 3.7 -1.9 1.0 -1.6
Chest pain or discomfort 0.1 0.1 0.2 -0.5 0.3 -0.2
Had major operations 2.0 2.4 5.2 -2.3 -0.8 -1.1
Age at last live birth 1.6 2.4 2.8 1.7 1.3 1.7
Family relationship satisfaction 1.0 1.2 2.1 -1.4 1.1 -0.6
Leg pain on walking 1.2 1.4 2.8 -1.7 0.6 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.0 -0.4 1.0 -0.4
Commuting to job workplace: Car/motor vehicle 3.6 4.1 11.6 -0.5 3.4 0.7
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.6 1.3 -0.5 0.4
Medication: Aspirin 5.9 7.7 20.0 -4.5 -0.3 -1.8
Supplements: Vitamin C 2.1 2.5 4.5 1.6 0.6 2.1
Knee pain experienced in last month 3.2 4.9 7.2 -2.7 2.0 -1.9
Hypertension (Self-reported) 3.4 9.3 15.8 -4.0 -1.5 -3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.1 3.6 5.5 -2.3 -0.9 -2.1
Illnesses of father: Heart disease 2.1 3.0 6.7 -2.6 0.7 -1.3
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.3 -0.3 0.4
Smoking status: Previous 3.9 5.8 8.9 -1.6 3.0 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.2 7.3 -1.1 2.7 -1.1
Whole body fat-free mass 0.8 4.6 12.5 -1.0 3.5 0.4
Leg fat-free mass (right) 0.9 4.7 11.1 -0.2 3.3 1.7
Arm fat percentage (left) 1.8 7.3 12.9 -2.6 3.6 1.4
Average weekly red wine intake 3.9 5.8 8.5 -2.6 -1.5 -2.9
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.5 0.4 -0.5 0.7
Mood swings 0.0 0.1 0.2 0.0 -0.1 -0.5
Loneliness, isolation 0.4 0.6 1.6 -0.4 1.3 0.1
Long-standing illness, disability or infirmity 1.6 2.4 5.4 -2.3 1.2 -0.6
Ever had bowel cancer screening 0.5 0.6 1.2 -1.1 -0.1 -0.7
Diabetes diagnosed by doctor 0.9 1.5 2.9 -1.7 -0.0 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 0.0 0.4 0.7
Friendships satisfaction 1.3 1.6 2.8 0.9 1.7 1.0
Qualifications: nursing, teaching 0.9 1.5 4.3 0.0 -2.1 -0.3
Commuting to job workplace: Walk 0.4 0.5 0.8 0.7 -0.9 0.2
Eye problems/disorders: Cataract 0.4 0.5 0.9 0.8 0.9 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.2 -0.6 0.9 1.1
Medication for cholesterol 1.0 1.5 2.6 1.6 0.3 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.6 0.4 -0.7 -0.8
Back pain experienced in last month 0.4 0.5 0.9 -0.9 0.8 0.2
Mineral and other dietary supplements 3.4 4.5 6.8 -2.4 -1.1 -2.6
Breast cancer (self-reported) 0.3 0.3 0.7 -0.5 -0.0 0.9
Asthma (self-reported) 0.4 0.8 1.9 0.4 1.4 -0.6
Osteoporosis (self-reported) 0.9 1.1 3.1 0.1 -0.4 1.8
Osteoarthritis (self-reported) 0.3 0.3 1.0 0.0 -1.0 -0.1
Medication: Aspirin 4.4 5.7 15.1 -3.9 0.1 -1.4
Medication: Gliclazide 5.8 6.5 12.0 -3.5 -0.5 -2.7
Illnesses of father: None of the above (group 1) 0.9 1.1 2.0 1.4 -1.1 0.3
Smoking status: Current 6.8 10.8 14.0 -3.7 -3.0 -3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.0 1.7 0.2 0.3
Whole body water mass 0.8 4.6 12.7 -1.1 3.6 0.3
Leg predicted mass (right) 0.8 4.4 10.5 -0.2 3.2 1.7
Arm fat mass (left) 2.2 9.0 17.8 -2.8 4.2 1.1
Number of self-reported non-cancer illnesses 3.0 5.3 9.5 -3.1 0.3 -2.5
Average weekly champagne plus white wine intake 0.6 0.9 2.2 0.7 -1.5 0.1
Miserableness 0.4 0.8 2.0 0.1 0.5 -1.4
Guilty feelings 2.7 4.1 5.0 2.2 1.6 2.2
Wears glasses or contact lenses 0.2 0.2 0.4 -0.2 -0.6 0.4
Ever taken oral contraceptive pill 0.9 1.0 2.4 0.7 1.6 -0.3
Hearing aid user 0.3 0.4 0.5 -0.6 0.7 -0.5
Mother’s age at death 1.8 2.3 3.0 1.7 -1.1 1.7
Financial situation satisfaction 4.5 5.6 6.8 1.9 2.5 2.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.8 0.5 0.9 0.8
Commuting to job workplace: Public transport 1.5 1.8 3.7 0.0 -1.9 1.3
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 -0.5 0.9 0.3
Medication: Blood pressure 1.3 2.5 4.6 -1.3 -2.1 -1.1
Pain type(s) experienced in last month: Hip pain 0.8 1.1 2.9 -1.7 0.2 -0.4
Supplements: Fish oil (including cod liver oil) 2.4 3.2 5.2 1.5 1.4 2.3
High cholesterol (Self-reported) 3.3 5.8 9.7 -3.1 -0.1 -2.8
Medication: Bendroflumethiazide 0.3 0.5 0.7 -0.8 -0.8 -0.1
Medication: Paracetamol 0.7 1.1 2.7 -0.8 -1.6 -0.1
Medication: Lisinopril 1.1 1.4 3.9 -2.0 0.2 -0.6
Medication: Atorvastatin 7.7 9.5 17.1 -4.1 -2.3 -2.5
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.1 -0.7 -0.9
Alcohol drinker status: Never 0.9 1.1 2.4 0.9 -1.5 -0.2
Ever smoked 3.9 6.9 12.4 -2.8 0.7 -3.5
Basal metabolic rate 1.1 5.9 15.4 -1.4 3.9 0.5
Leg fat percentage (left) 4.0 14.4 24.5 -4.2 4.9 -1.0
Arm fat-free mass (left) 1.4 7.0 16.7 -2.0 4.1 -0.5
Number of operations (self-reported) 0.9 1.3 3.1 -1.8 -0.1 -0.9
Average weekly beer plus cider intake 0.9 1.2 3.2 -0.1 1.8 0.7
Irritability 0.8 1.3 3.5 1.9 -0.4 0.6
Risk taking 0.3 0.4 1.3 -1.1 0.1 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 -0.6 -0.7 -0.8
Fractured/broken bones in last 5 years 0.8 1.1 2.1 -1.4 -0.5 -1.0
Age started oral contraceptive pill 1.8 2.3 3.4 1.9 -0.0 1.8
Diastolic blood pressure, automated reading 0.1 0.3 0.7 -0.4 0.8 0.4
Ever depressed for a whole week 0.7 0.9 2.3 0.5 -1.5 -0.3
Unable to work because of sickness or disability 1.2 1.6 2.9 -1.7 -0.5 -1.3
Commuting to job workplace: Cycle 1.1 1.4 3.8 1.9 -0.5 0.3
Myopia 6.0 8.7 12.7 3.6 -2.0 3.1
Vascular/heart problems diagnosed by doctor 2.8 7.6 15.7 4.0 0.8 2.5
Cholesterol lowering medication 2.1 3.1 4.4 -2.1 1.2 -1.8
Medication: Omeprazole (e.g. Zanprol) 3.3 4.1 8.1 -2.9 -1.0 -1.8
Pain experienced in last month 2.3 3.8 6.8 2.6 -1.0 1.9
Supplements: Calcium 1.6 1.8 2.8 1.7 -0.8 1.4
Basal cell carcinoma (self-reported) 0.7 0.9 1.5 -0.5 -1.2 -0.9
Heart attack/myocardial infarction (self-reported) 1.7 2.1 6.2 -2.5 -0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.0 0.8 0.1
Heart disease (siblings) 1.4 1.7 3.5 -1.9 0.0 -1.3
Alcohol drinker status: Previous 0.7 0.7 1.9 -0.6 -0.0 -1.4
Pack years of smoking 0.8 1.2 2.1 -1.4 -1.0 -0.7
Impedance of whole body 1.0 4.9 9.5 -1.4 -3.1 -1.7
Leg fat mass (left) 3.6 13.9 26.3 -3.9 5.1 -0.4
Arm predicted mass (left) 1.5 7.9 19.3 -2.0 4.4 -0.4