TWAS hub - SESN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2070	0.0770	0.0084	0.005	NA	-0.001	NA	0.006	1.5e-01	NA	3.8e-01	NA	1.3e-01
2	GTEx	Cells Transformed fibroblasts	0.1450	0.0440	0.0011	0.049	NA	0.095	NA	0.090	1.5e-04	NA	1.3e-07	NA	2.9e-07
3	GTEx	Vagina	0.4650	0.1360	0.0056	0.004	NA	0.055	NA	-0.011	2.5e-01	NA	2.2e-02	NA	6.8e-01
4	METSIM	Adipose	0.0464	0.0249	0.0380	0.009	0.018	0.045	0.032	0.022	1.5e-02	7.7e-04	2.4e-07	1.0e-05	2.3e-04
5	NTR	Blood	0.0273	0.0105	0.0031	0.003	0.010	0.002	0.011	0.003	2.7e-02	2.2e-04	5.2e-02	9.3e-05	3.6e-02
6	YFS	Blood	0.5877	0.0356	0.0000	0.163	0.211	0.291	0.305	0.296	5.6e-51	4.0e-67	1.3e-96	5.9e-102	1.5e-98

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hypothyroidism (self reported)	3.6	8.2	24.1	2.0	3.0	0.3	-4.9	-3.4	0.6
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	13.0	1.1	3.1	-0.8	-3.6	-2.6	1.3
Hayfever, allergic rhinitis or eczema	2.7	5.8	16.9	-0.4	-1.9	-0.3	4.1	3.2	2.0
Hearing aid user	2.7	3.0	7.2	-2.3	-1.3	0.8	1.2	2.7	1.4
Allergy or Eczema	2.6	6.9	16.6	-1.3	-1.6	0.4	4.0	4.1	2.1
Medication: Levothyroxine sodium	2.6	4.4	10.4	0.1	2.2	-1.4	-2.8	-3.2	1.0
Diastolic blood pressure, automated reading	2.5	7.8	39.3	6.3	-0.6	1.9	-1.6	0.5	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	6.2	-2.0	-0.0	-2.2	2.5	0.8	1.2
Medication for hormone replacement therapy	2.2	2.5	5.9	1.8	-2.4	0.7	0.7	0.1	-2.2
Heart disease (siblings)	2.2	2.7	7.9	2.8	1.2	-1.7	-0.0	-1.6	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	6.7	-1.1	-1.0	-2.6	-1.5	-1.5	0.4
Type 2 Diabetes (T2D) (2012)	2.0	2.3	10.6	-3.3	-1.2	-0.2	0.4	-1.2	0.2
Illnesses of father: Heart disease	2.0	2.7	8.9	1.2	-3.0	-0.2	-0.3	-0.8	-2.3
Financial situation satisfaction	2.0	2.5	7.0	2.6	-1.7	-0.0	-0.4	-0.0	-2.2
Diabetes (father)	1.9	2.4	4.8	-2.2	0.8	0.4	-2.2	-1.9	-0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	6.0	-0.2	-1.1	-0.5	2.3	0.3	-2.5
Supplements: Zinc	1.8	1.9	5.1	0.3	-1.5	2.3	1.4	0.2	-1.5
Taking other prescription medications	1.8	2.8	6.9	-2.6	0.9	-1.5	0.5	0.4	2.5
Noisy workplace	1.8	2.2	8.2	-0.7	-0.8	0.4	-2.9	0.0	-1.9
Basal cell carcinoma (self-reported)	1.8	2.2	7.7	1.2	-1.6	-0.1	2.8	0.8	-0.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	10.6	-0.6	-3.2	-0.4	-0.0	-0.2	-0.1
Exposure to tobacco smoke at home	1.7	1.9	3.7	0.4	1.7	-0.8	-1.9	-1.8	-0.7
Heart disease (mother)	1.7	2.1	3.6	1.9	-1.8	-0.7	-0.5	-1.6	-1.5
Medication: Atenolol	1.6	2.0	5.6	-0.5	-1.1	-1.5	2.4	1.3	0.8
Allergy	1.6	3.7	8.6	0.4	1.8	0.4	-2.9	-2.4	-2.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.8	-0.0	0.2	0.3	2.6	2.4	-0.2
Tense / ‘highly strung’	1.6	2.7	6.2	1.3	-2.5	-0.0	2.2	-1.3	-1.3
Osteoporosis (self-reported)	1.6	2.0	4.0	-0.6	-1.5	-2.0	0.2	1.5	1.8
Illnesses of father: High blood pressure	1.6	2.0	5.4	-1.2	0.6	0.8	-2.0	-2.3	0.3
Primary Biliary Cirrhosis	1.5	2.1	9.8	-0.1	3.1	1.0	0.8	0.5	-1.1
Chronotype (morning person)	1.5	3.4	16.3	-1.5	-0.2	-1.1	-0.7	4.0	0.0
Depression (self-reported)	1.5	1.8	3.9	0.1	-2.0	-2.0	-1.3	0.1	-1.2
Emphysema/chronic bronchitis	1.5	1.7	6.6	0.1	-0.5	-0.2	1.7	2.6	0.8
Mean time to correctly identify matches	1.5	2.8	12.6	-3.6	-1.0	0.6	-0.9	-1.1	1.0
Reaction Time	1.4	2.7	10.4	-3.2	-0.9	0.8	-0.8	-1.3	1.3
Hearing difficulty/problems: Yes	1.4	2.1	6.7	-2.6	-0.9	-1.3	-1.0	1.5	0.4
Vitamin and mineral supplements	1.4	1.9	5.6	1.8	1.1	-0.3	0.1	-2.4	-1.3
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.2	-0.4	-0.8	-1.5	1.6	2.0	1.1
Mouth/teeth dental problems: Loose teeth	1.4	1.6	6.8	-2.6	-0.2	-0.5	-0.4	1.1	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.3	1.2	-0.9	-1.8	-0.7	-0.7	-1.8
Medication: Gliclazide	1.4	1.6	3.7	0.8	-1.2	-0.0	1.6	1.9	-1.0
Irritability	1.4	2.3	5.1	1.4	-2.3	-0.4	2.2	-0.0	-1.3
Unable to work because of sickness or disability	1.4	1.8	6.0	-0.3	-2.5	0.9	0.0	0.3	-1.9
Supplements: Calcium	1.4	1.5	6.2	-0.9	-2.5	-0.0	0.7	0.9	0.9
Frequency of depressed mood in last 2 weeks	1.3	1.8	5.1	-1.6	-2.2	-0.8	1.3	1.0	0.3
Relative age of first facial hair	1.3	2.7	14.5	-0.5	-3.8	0.5	-0.7	-0.9	-0.1
Qualifications: CSEs or equivalent	1.3	1.7	4.0	1.2	1.5	0.1	-1.7	-2.0	0.1
Happiness	1.3	1.5	4.1	0.8	-2.0	-1.1	1.7	0.2	0.5
Prospective memory result	1.3	1.6	4.8	0.3	-2.2	-1.9	1.1	-0.3	0.2
Migraine (self-reported)	1.3	1.6	5.3	-2.3	1.3	0.3	0.5	0.4	1.5
Leg pain on walking	1.3	1.6	4.8	-1.0	1.5	2.2	1.0	0.6	0.4
Medication: Aspirin	1.3	1.6	7.4	-0.5	0.1	-0.2	2.7	-0.8	-1.2
Ever taken oral contraceptive pill	1.3	1.4	7.7	-0.3	0.1	-0.2	-2.8	0.9	0.2
Commuting to job workplace: Public transport	1.3	1.6	4.5	1.5	0.2	1.4	1.1	0.1	2.1
Medication: Lisinopril	1.3	1.6	4.8	-1.3	-1.2	-2.2	-0.1	-1.2	0.7
Medication: Atorvastatin	1.3	1.7	6.6	-2.6	-0.3	-1.7	-0.1	-0.2	-0.4
Depression (Nagel 2018)	1.2	1.7	3.5	-1.9	-1.6	-0.9	1.3	0.9	0.9
Sensitivity / hurt feelings	1.2	2.0	5.6	2.0	0.3	-0.9	1.2	-0.3	-2.4
Alcohol usually taken with meals	1.2	1.9	6.7	-1.1	-0.5	-1.6	-0.8	2.6	0.5
Hair/balding pattern: Pattern 2	1.2	1.6	3.5	-1.9	0.7	-1.4	-0.3	-0.6	1.7
Heart attack	1.2	1.5	4.4	2.1	-0.3	-1.8	0.3	1.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	7.8	-0.0	-1.7	0.4	2.8	0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	6.6	-1.2	-2.6	-0.6	0.7	0.5	0.3
Chest pain or discomfort	1.2	1.8	6.9	-0.4	-2.6	-0.9	0.4	-1.6	0.3
Medication: Aspirin	1.2	1.6	5.7	-0.5	0.3	0.3	2.4	-1.1	-1.5
Eye problems/disorders: Glaucoma	1.2	1.4	3.8	1.1	1.0	1.4	-0.5	-0.5	-1.9
Myopia	1.2	1.7	3.6	-0.6	-1.0	1.0	-1.9	-1.8	1.1
Breast Cancer	1.1	2.7	6.4	1.5	-2.0	-0.5	2.5	1.7	0.5
Rheumatoid Arthritis	1.1	1.5	4.7	-1.2	0.7	-0.5	-1.4	-2.2	0.7
Multivitamins +/- minerals	1.1	1.4	6.8	-0.3	-0.7	0.6	0.0	2.6	0.8
Number of incorrect matches in round	1.1	1.8	7.4	1.5	-0.5	-0.7	2.7	0.0	-0.5
Hearing difficulty/problems with background noise	1.1	1.7	3.3	-1.5	-1.8	-1.7	-1.1	0.7	0.2
Number of live births	1.1	1.6	3.8	-2.0	1.2	1.0	-1.4	0.2	1.1
Medication: Lansoprazole	1.1	1.2	4.9	-1.5	0.6	-0.0	2.2	-0.2	0.0
Loud music exposure frequency	1.1	1.2	3.6	-1.2	-1.9	-0.2	-0.8	0.2	1.1
Glaucoma (self-reported)	1.1	1.3	2.3	1.3	1.1	1.2	-0.4	-1.0	-1.5
Exposure to tobacco smoke outside home	1.1	1.4	4.6	-2.1	0.5	0.2	-0.8	-1.7	0.4
Eye problems/disorders: None of the above	1.1	1.3	2.1	-1.3	1.0	-1.2	0.3	-1.2	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	6.2	-0.9	2.5	0.5	0.3	-0.9	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.8	-0.7	-0.7	-1.3	-1.0	1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	6.5	0.7	0.1	-0.5	2.6	1.0	2.3
Friendships satisfaction	1.1	1.3	4.2	-0.1	-2.0	-1.9	-0.4	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	8.0	-0.3	-1.1	-2.8	0.4	-1.1	-0.2
Number of self-reported non-cancer illnesses	1.1	1.9	5.4	-2.3	-0.9	-0.9	0.9	-0.1	1.9
Medication: Blood pressure	1.1	2.1	3.3	-1.4	-1.8	-0.6	1.7	-1.0	1.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.9	1.3	-1.2	1.1	-1.7	0.7	0.6
Lupus	1.0	1.5	4.9	-0.6	2.2	1.7	-0.5	0.4	0.7
Blood Platelet Count	1.0	11.1	26.1	-0.1	-0.6	-5.1	2.6	3.9	4.2
Waist Hip Ratio (WHR)	1.0	4.5	13.9	-0.4	-1.0	-2.0	3.7	-1.9	2.0
Number of treatments/medications taken	1.0	1.7	4.6	-1.6	0.5	-2.1	0.4	0.9	1.5
Average weekly spirits intake	1.0	1.3	3.2	-1.3	0.7	1.3	-1.8	0.7	-0.4
Ever had hysterectomy (womb removed)	1.0	1.2	3.7	-1.9	-0.3	-0.5	0.8	-0.8	1.3
Lung cancer (father)	1.0	1.1	2.9	-1.0	1.7	-0.5	0.6	-0.3	1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	4.3	1.3	-2.1	-1.2	1.3	0.4	0.3
Birth weight	1.0	2.1	7.3	-0.4	-1.7	-0.6	2.7	-0.0	1.3
Breast cancer (self-reported)	1.0	1.2	5.2	0.6	-0.2	2.3	-0.4	0.4	-1.0
Osteoarthritis (self-reported)	1.0	1.3	5.3	-2.3	-0.1	0.2	1.3	-0.0	-0.9
Illnesses of father: None of the above (group 1)	1.0	1.2	3.9	-0.8	0.8	-0.3	0.8	2.0	1.1
Ever depressed for a whole week	1.0	1.2	4.0	-0.1	-0.6	0.1	2.0	1.6	0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.6	1.9	-0.4	-1.5	0.3	1.0	-0.7
Schizophrenia (2018)	0.9	1.8	5.2	0.4	-2.3	-0.6	-0.7	-2.1	0.2
Prostate Cancer	0.9	1.3	5.3	0.7	0.7	-0.9	0.3	-2.3	-0.9
Crohns Disease (2012)	0.9	1.5	3.5	-1.7	-1.9	0.9	1.2	-0.3	0.6
Fasting Glucose	0.9	1.1	4.0	0.8	-2.0	-0.9	0.0	-0.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	1.1	-1.4	-0.5	-1.0	1.3	-0.1
Maternal smoking around birth	0.9	1.3	3.5	-1.9	0.2	1.1	1.2	0.8	-1.2
Medication: Cholesterol lowering	0.9	1.4	6.3	0.4	0.7	-2.5	0.6	-0.2	-1.1
Headache pain in last month	0.9	1.5	6.3	-2.5	-0.9	-1.0	-0.7	0.3	-0.5
Number of children fathered	0.9	1.0	5.4	0.4	2.3	0.3	-0.7	0.2	0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	5.0	1.4	-1.0	-0.5	-2.2	-0.2	1.1
Family relationship satisfaction	0.9	1.1	3.0	0.8	-1.0	-1.7	0.6	-1.2	0.4
Medication for cholesterol	0.9	1.4	5.1	0.1	2.3	0.1	-1.1	1.3	0.2
Alcohol drinker status: Previous	0.9	1.0	4.4	-0.0	-0.4	-2.1	0.6	1.0	0.4
Bipolar Disorder or Schizophrenia	0.8	2.1	5.1	-0.8	-2.3	-1.8	-0.0	-1.8	-0.2
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	-1.4	-1.3	-0.2	-0.3	-1.2	0.5
Crohns Disease (2017)	0.8	1.8	5.7	-1.7	-0.3	1.4	2.4	-0.1	0.4
Coronary Artery Disease (CAD)	0.8	1.0	2.0	1.3	-1.4	-0.3	0.5	-1.1	0.6
Mean Putamen Volume	0.8	0.9	3.6	-0.4	0.7	-0.1	-0.8	-1.9	-0.7
LDL Cholesterol	0.8	1.2	4.3	-0.7	1.1	-1.0	-0.4	2.1	-0.3
Blood Eosinophil Count	0.8	6.2	18.7	-0.0	0.7	-4.3	-2.9	-1.1	2.9
Respiratory disease	0.8	1.9	5.0	-0.2	-0.9	-0.7	1.6	2.2	1.5
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.4	1.6	0.7	-0.1	-1.1	-1.0	-1.8
Neuroticism	0.8	1.9	7.9	1.3	-0.5	0.1	2.8	-0.9	-1.0
Hand grip strength (left)	0.8	2.0	8.1	0.1	2.8	0.9	-0.2	1.2	1.4
Hand grip strength (right)	0.8	2.2	6.3	-0.6	2.5	1.7	-0.6	1.2	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.0	-0.4	-2.0	-0.8	-0.7	-0.1	1.0
Medication: Simvastatin	0.8	1.1	2.0	0.6	1.1	-1.3	1.4	-1.1	-0.6
Impedance of arm (right)	0.8	3.9	9.5	-2.4	-3.1	-1.5	1.3	-1.1	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.4	-1.6	-0.0	1.4	0.1	-1.2	-0.1
Impedance of arm (left)	0.8	3.6	10.8	-2.1	-3.3	-1.3	1.5	-0.8	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	0.5	0.6	1.5	-0.0	-1.1	-1.4
Medication: Ibuprofen	0.8	0.9	1.7	0.5	1.2	0.8	-1.3	-1.2	-0.3
Medication: Allopurinol	0.8	1.1	1.9	1.3	0.3	-1.4	-1.2	-0.9	-0.8
Supplements: Vitamin C	0.8	0.9	4.3	-1.1	-2.1	0.1	0.1	0.4	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.0	-1.7	-0.6	0.5	1.1	0.7	0.3
Ever had bowel cancer screening	0.8	1.0	3.8	1.0	2.0	-0.6	0.8	0.1	-0.3
Back pain experienced in last month	0.8	1.1	3.6	-0.7	1.2	0.1	0.3	1.9	0.9
Number of operations (self-reported)	0.8	1.2	4.7	0.2	-0.4	-0.8	0.9	-2.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.2	-1.8	0.7	0.2	1.0	0.2	-0.9
Bipolar Disorder (2018)	0.7	1.2	2.6	-1.6	-0.8	-1.6	1.0	-0.3	-0.6
Neuroticism (Nagel 2018)	0.7	1.6	6.5	0.3	-0.9	-0.9	2.5	-0.6	-1.1
Worry (Nagel 2018)	0.7	1.6	6.3	0.9	-1.0	0.2	2.5	-0.6	-1.0
Alzheimer’s Disease (in father)	0.7	0.8	4.0	-0.5	-0.1	-0.4	-0.3	2.0	0.1
Ovarian Cancer	0.7	1.0	4.2	-0.1	0.8	0.3	-2.0	0.1	0.9
Ulcerative Colitis	0.7	1.1	2.7	0.3	-0.8	1.7	0.5	1.6	-0.2
Angina	0.7	1.0	3.4	0.2	-1.8	0.1	0.8	0.1	-1.4
Nervous feelings	0.7	1.3	3.6	0.5	0.6	-1.9	1.5	-1.0	-0.6
Worrier / anxious feelings	0.7	1.3	3.9	2.0	-1.0	-0.1	0.8	0.2	-1.4
Falls in the last year	0.7	0.9	3.9	-0.4	-2.0	0.5	0.3	0.6	0.9
Pulse rate	0.7	1.2	5.9	1.1	0.4	0.1	2.4	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	0.4	0.8	0.4	-1.7	-1.0	-0.6
Length of working week for main job	0.7	0.8	2.0	-0.6	0.3	1.1	-0.9	1.4	-0.1
Pulse wave reflection index	0.7	0.9	1.6	0.6	-1.1	0.8	-1.3	0.9	0.8
Leg fat percentage (right)	0.7	2.7	9.7	-1.6	3.1	0.2	-0.8	-1.7	0.2
Number of full brothers	0.7	0.9	4.0	-0.3	0.8	-0.3	-0.7	2.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	-0.8	0.9	0.6	-0.7	1.4	0.6
Medication: Omeprazole	0.7	0.8	2.6	-1.6	-1.1	-0.2	0.7	-0.1	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	3.6	-0.7	-1.9	-1.3	0.8	0.5	-0.4
Guilty feelings	0.7	1.1	2.9	0.5	-1.1	-1.1	1.7	0.2	-1.1
Leg fat percentage (left)	0.7	2.4	7.7	-1.7	2.8	0.1	-0.9	-1.7	-0.1
Average weekly beer plus cider intake	0.7	1.0	3.0	0.1	-1.4	-0.3	1.7	-0.8	-0.4
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-1.2	-0.5	0.9	-0.3	1.5	0.4
Commuting to job workplace: Cycle	0.7	0.8	2.7	-1.6	-0.4	0.9	-0.4	0.6	0.9
Major Depression (MDD)	0.6	0.8	2.2	0.8	-1.5	-1.0	0.6	0.6	0.1
Bipolar Disorder (2011)	0.6	0.6	2.5	-0.9	-0.1	-1.6	0.2	-0.4	-0.5
Schizophrenia (2014)	0.6	1.4	3.3	1.0	-1.8	-1.2	-0.6	-1.5	-0.1
Medication: Metformin	0.6	0.8	2.3	1.2	-0.9	-0.4	1.5	0.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	1.0	-1.1	-0.9	1.6	0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.7	-2.2	0.9	0.3	-1.0	0.9	-0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	0.7	-1.2	1.5	0.3	0.3	-0.3
Neuroticism score	0.6	1.2	4.0	1.3	-0.8	0.2	2.0	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.3	2.1	-0.1	0.2	1.7	1.2	0.1
Birth weight of first child	0.6	1.0	3.8	-0.7	-0.9	-0.1	1.9	1.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-1.0	-1.3	0.4	-1.2	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	5.1	-0.2	-0.5	2.3	0.2	0.5	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.7	0.7	-0.1	1.4	1.0	-0.3
Age at first live birth	0.6	1.1	2.9	1.0	-1.7	-1.2	0.7	-0.0	-0.9
Angina (self-reported)	0.6	0.9	3.4	-0.0	-1.9	-0.3	0.9	0.3	-0.8
Leg fat mass (right)	0.6	2.2	8.1	-0.7	2.8	0.4	-0.4	-2.1	-0.3
Comparative height size at age 10	0.6	3.3	8.4	1.0	1.2	-1.4	2.9	-1.7	2.1
Number of full sisters	0.6	0.7	1.1	0.2	1.0	-0.7	-0.8	-0.9	-1.0
Knee pain experienced in last month	0.6	0.9	4.8	-2.2	-0.4	-0.2	-0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.6	0.9	-0.9	-1.6	-0.2	-0.3	-0.3
Mineral and other dietary supplements	0.6	0.8	2.2	0.5	1.5	-0.1	-0.6	-1.2	-0.8
High cholesterol (Self-reported)	0.6	1.1	4.0	-0.8	0.6	-2.0	0.9	-0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.1	-0.3	-1.7	-1.5	1.5	-0.4	1.4
Ulcerative Colitis (UC)	0.5	0.9	2.3	1.5	1.0	1.2	-0.1	-0.0	-0.7
Age at First Birth	0.5	0.7	1.8	0.7	-0.1	-0.3	0.7	-1.4	-1.2
Neuroticism (2016)	0.5	0.7	1.8	0.8	-1.1	-0.3	1.3	-0.7	-0.3
Triglycerides	0.5	0.8	2.5	-1.6	0.6	0.2	0.7	0.6	1.0
Smoking Status	0.5	1.2	2.4	-0.4	-0.9	0.1	1.6	-1.5	1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.6	-0.1	-0.5	-1.1	-0.3	-1.6	-0.3
Medication: Co-codamol	0.5	0.6	2.1	-0.0	0.1	1.4	1.1	0.4	0.4
Diabetes (mother)	0.5	0.6	1.4	0.9	-0.7	-1.2	0.3	-0.6	-0.8
Trunk fat percentage	0.5	2.1	6.2	-2.3	1.1	-0.0	0.2	-2.5	0.2
Current tobacco smoking	0.5	0.8	3.1	-0.2	-0.3	0.1	-0.2	-1.8	1.2
Fed-up feelings	0.5	0.9	2.8	1.2	-1.7	0.5	-0.3	-0.1	-0.7
Relative age voice broke	0.5	0.7	1.7	0.7	-1.3	0.4	-0.4	-1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.6	-1.9	1.0	0.4	-0.1	1.0	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	0.7	0.1	0.7	1.4	-0.1	-0.9
High blood pressure (mother)	0.5	0.7	1.5	-0.0	1.2	-1.1	-1.1	0.1	-0.6
Trunk fat mass	0.5	2.2	7.2	-1.5	1.9	0.0	0.6	-2.7	0.2
Waist circumference	0.5	1.9	9.0	-0.4	1.4	-0.1	0.8	-3.0	-0.4
Had other major operations	0.5	0.6	2.5	-0.6	-0.1	0.4	0.1	-1.6	0.8
Qualifications: None of the above	0.5	1.2	4.2	0.3	0.1	0.5	-1.5	-0.3	-2.1
Mouth/teeth dental problems	0.5	0.8	1.9	-0.4	0.2	1.2	1.1	1.4	-0.2
Asthma	0.5	1.0	2.0	0.9	-0.5	-0.9	1.1	1.4	0.9
Illnesses of mother	0.5	0.6	1.4	-0.6	-1.0	0.7	-0.5	0.2	1.2
Body fat percentage	0.5	2.1	5.8	-1.9	1.8	0.2	-0.2	-2.4	-0.0
Worry too long after embarrassment	0.5	0.8	2.0	1.0	0.8	-1.1	1.4	-0.2	-0.1
Qualifications: College or University degree	0.5	1.4	2.5	-0.1	-1.6	1.3	0.3	1.6	1.4
Medication: Blood pressure	0.5	0.9	2.9	0.0	-0.5	-1.5	0.2	-0.6	-1.7
Whole body fat mass	0.5	2.1	6.5	-1.0	2.2	0.3	0.3	-2.5	-0.2
Arm predicted mass (right)	0.5	2.7	9.4	1.8	3.1	0.4	0.8	-1.6	-0.4
Pulse rate, automated reading	0.5	1.6	5.7	2.4	0.9	1.4	0.3	-0.7	0.8
Suffer from ‘nerves’	0.5	0.7	1.8	-0.3	-1.4	0.9	1.0	0.2	0.7
Loneliness, isolation	0.5	0.7	1.2	-0.7	1.1	-1.0	1.1	-0.6	-0.3
Qualifications: nursing, teaching	0.5	0.8	2.8	-0.6	-0.8	-1.7	0.8	-0.1	-0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-1.3	-0.3	0.5	0.9	0.8	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.5	-0.1	-1.6	0.7	-0.5	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	-0.2	0.8	0.9	-1.1	0.4	-0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	0.2	-1.1	0.4	0.5	1.1	1.0
Medication: Paracetamol	0.5	0.8	2.4	-0.4	0.8	-0.7	0.9	1.6	-0.0
Arm fat-free mass (left)	0.5	2.4	9.4	1.4	3.1	0.2	0.6	-1.7	-0.3
Risk taking	0.5	0.7	1.6	-0.7	-1.3	-0.5	0.7	0.8	-0.8
Leg fat mass (left)	0.5	2.1	7.3	-0.8	2.7	0.4	-0.4	-2.0	-0.4
Arm predicted mass (left)	0.5	2.3	9.1	1.3	3.0	0.1	0.9	-1.5	0.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.8	0.0	0.1	1.6	1.7	0.4	-0.2
HDL Cholesterol	0.4	0.7	3.2	0.4	-1.8	0.2	0.7	0.6	0.3
Blood White Count	0.4	2.7	6.7	0.8	-2.3	-1.5	0.2	-2.6	1.2
BMI	0.4	2.5	8.7	-0.7	3.0	1.5	-0.5	-1.7	-0.8
Height	0.4	6.8	23.2	-1.1	0.1	-1.4	3.7	0.2	4.8
Lung FVC	0.4	2.0	4.5	-0.8	-1.4	0.7	-2.1	1.3	1.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.4	1.5	0.2	-0.4	0.0	-0.4	-0.3
Age when periods started (menarche)	0.4	0.9	1.7	0.3	0.7	-1.2	-0.7	-1.3	1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	-0.9	-0.6	0.9	-0.0	0.0	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.6	-0.0	-0.6	0.6	-0.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	-0.5	-0.7	-1.2	0.5	0.3	0.2
Body mass index (BMI)	0.4	1.6	3.7	-0.6	1.9	1.0	-1.0	-1.7	-1.0
Financial difficulties in last 2 years	0.4	0.5	1.4	0.5	-1.2	0.5	0.6	-0.1	-0.9
Diabetes (self-reported)	0.4	0.6	1.6	1.0	-0.6	-0.5	-0.0	-0.5	-1.3
Medication: Ramipril	0.4	0.5	2.0	0.0	-0.1	-1.4	0.8	0.2	0.4
Weight	0.4	2.0	6.4	-0.2	2.3	0.3	0.6	-2.5	0.1
Arm fat percentage (right)	0.4	1.4	4.9	-1.5	1.0	0.6	-0.2	-2.2	-0.3
Trunk fat-free mass	0.4	2.1	6.1	1.9	2.5	-0.3	1.3	-1.1	0.5
Alcohol intake versus 10 years previously	0.4	0.5	2.2	-0.1	-0.1	1.5	0.7	-0.6	0.0
Trunk predicted mass	0.4	2.0	5.7	1.8	2.4	-0.3	1.3	-1.1	0.5
Standing height	0.4	4.3	13.5	0.7	0.9	-1.5	3.7	-1.8	2.2
Medication: Paracetamol	0.4	0.7	2.2	-0.2	0.7	-0.8	0.6	1.5	-0.8
Arm fat-free mass (right)	0.4	2.1	8.3	1.5	2.9	0.2	1.1	-1.0	-0.2
Neck or shoulder pain in last month	0.4	0.5	1.5	0.3	-0.8	1.2	0.7	0.6	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.0	-1.0	-1.0	-0.0	0.7	-0.6	0.2
Had major operations	0.4	0.5	0.9	-0.6	-0.7	-0.7	1.0	-0.8	-0.5
Hypertension (Self-reported)	0.4	1.1	2.5	-1.0	-0.7	-1.5	0.5	-1.6	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-1.0	1.0	-0.1	-0.6	-0.5	0.5
Mood swings	0.4	0.7	1.3	1.1	-1.1	-0.4	0.8	-0.5	-0.9
Diabetes diagnosed by doctor	0.4	0.7	2.0	1.2	-0.4	-0.2	-0.1	-0.6	-1.4
Asthma (self-reported)	0.4	0.8	1.1	0.9	-0.7	-1.0	1.0	1.1	0.6
Smoking status: Current	0.4	0.7	2.6	0.1	-0.4	0.3	-0.4	-1.6	1.1
Arm fat mass (left)	0.4	1.7	6.3	-0.8	1.7	0.6	0.0	-2.5	-0.5
Miserableness	0.4	0.7	1.3	1.1	-0.9	-1.0	-0.1	-0.9	-0.1
Mother’s age at death	0.4	0.5	1.5	0.3	1.2	-0.2	0.2	0.3	1.0
Cholesterol lowering medication	0.4	0.6	1.1	-0.5	-0.3	0.4	1.0	-1.0	-0.9
Pain experienced in last month	0.4	0.6	1.6	0.8	-1.3	-0.5	0.8	-0.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	-0.8	0.3	-0.8	-0.8	-0.8	0.1
Pack years of smoking	0.4	0.6	1.2	0.5	1.0	-0.7	-0.2	-1.1	-0.6
Impedance of whole body	0.4	2.3	4.8	-2.2	-1.9	-1.3	1.2	-0.4	1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.1	-0.7	0.5	-0.3	0.1	0.4
Lung FEV1/FVC ratio	0.3	1.6	4.2	2.0	0.7	-0.5	-0.8	-0.5	-1.9
Pack years adult smoking proportion	0.3	0.5	1.3	0.3	0.8	-0.9	0.1	-1.1	-0.1
Impedance of leg (right)	0.3	1.2	2.5	-1.4	0.6	-1.4	0.8	0.2	1.6
Townsend deprivation index at recruitment	0.3	0.5	2.0	-0.6	0.3	-0.2	0.3	-1.4	-0.5
Average weekly fortified wine intake	0.3	0.3	0.9	-1.0	-0.6	-0.3	-0.2	0.3	0.8
Serious illness, injury or assault to yourself	0.3	0.4	1.2	0.6	-0.9	0.0	0.2	0.2	-1.1
Supplements: Glucosamine	0.3	0.4	1.2	0.3	-0.2	-1.1	0.6	-0.7	-0.7
Sitting height	0.3	2.4	4.6	2.1	2.1	-0.6	1.9	-1.1	0.6
Leg predicted mass (left)	0.3	1.4	3.2	1.0	1.7	0.2	1.0	-1.8	0.3
Fluid intelligence score	0.3	0.5	1.0	-0.5	-0.8	-0.9	0.7	0.0	1.0
Hip circumference	0.3	1.4	4.2	-0.5	1.9	0.5	-0.3	-2.0	-0.5
Father’s age at death	0.3	0.4	1.2	-0.9	-1.1	0.2	-0.3	0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.2	0.1	-0.9	-0.3	-0.4	-1.5	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	0.9	-0.5	0.9	0.7	0.4	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	1.2	0.4	-0.4	-0.2	0.7	0.1
Arm fat mass (right)	0.3	1.4	5.7	-0.6	1.4	0.5	0.1	-2.4	-0.3
Breastfed as a baby	0.3	0.4	1.4	0.6	-0.1	-0.3	-0.9	1.2	0.1
Peak expiratory flow (PEF)	0.3	0.6	1.5	0.6	1.2	0.5	-1.1	0.1	-0.7
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.7	0.2	-0.5	-0.9	-0.7	0.2
Comparative body size at age 10	0.3	0.7	2.1	-1.4	-0.3	0.7	-0.6	1.1	-0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	0.7	-1.1	-0.7	1.0	-0.5	-0.4
Pulse wave peak to peak time	0.3	0.4	1.5	-1.2	-0.1	0.4	0.3	-0.8	-0.1
Shortness of breath walking on level ground	0.3	0.4	1.3	-0.5	-0.6	-1.1	-0.5	-0.6	-0.1
Overall health rating	0.3	0.6	1.1	0.6	-0.9	-0.8	1.0	-0.5	-0.1
Age at last live birth	0.3	0.5	1.0	0.1	-1.0	0.2	0.9	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.3	0.9	-0.5	-0.2	0.9	0.5
Whole body fat-free mass	0.3	1.9	5.2	1.7	2.3	0.1	1.2	-1.4	0.2
Arm fat percentage (left)	0.3	1.4	4.8	-1.4	0.8	0.7	-0.1	-2.2	-0.6
Average weekly red wine intake	0.3	0.5	2.4	-0.6	-1.5	-0.2	0.0	-0.1	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.2	-0.2	-0.8	0.6	0.1	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.3	0.4	-0.3	0.3	-1.5	1.1	0.6
Whole body water mass	0.3	2.0	5.2	1.7	2.3	0.0	1.3	-1.4	0.2
Wears glasses or contact lenses	0.3	0.3	0.7	0.4	-0.7	0.8	0.2	0.8	-0.2
Ever smoked	0.3	0.5	0.9	0.4	-0.9	-0.7	-0.8	-0.3	0.9
Basal metabolic rate	0.3	1.9	5.3	1.2	2.3	0.1	1.2	-1.7	0.3
Age started oral contraceptive pill	0.3	0.3	0.9	-0.1	0.8	1.0	-0.4	-0.1	-0.5
Depressed Affect (Nagel 2018)	0.2	0.3	1.2	-0.1	-0.5	-0.7	1.1	-0.2	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.6	0.3	-0.8	-0.6	1.3	-0.7	0.7
HbA1C	0.2	0.3	0.5	-0.2	-0.7	0.5	0.6	-0.7	-0.1
Blood Red Count	0.2	2.3	4.5	1.9	1.3	-0.0	-1.1	1.6	2.1
Heel T-Score	0.2	1.8	8.0	-2.8	0.3	-0.4	0.0	1.1	-1.1
Cardiovascular Disease	0.2	0.8	2.3	0.2	-0.5	-0.9	0.5	-1.5	-1.0
Severe depression (siblings)	0.2	0.2	0.5	-0.4	0.5	-0.4	-0.1	-0.7	0.5
Leg fat-free mass (left)	0.2	1.3	2.9	1.0	1.7	0.1	0.9	-1.7	0.3
High blood pressure	0.2	0.6	1.3	-1.1	-1.0	-0.8	0.0	-1.0	0.2
Impedance of leg (left)	0.2	1.1	2.5	-1.6	0.2	-1.5	0.7	0.1	1.1
Had menopause	0.2	0.2	0.5	0.7	0.2	0.4	0.6	-0.4	-0.5
Illnesses of siblings	0.2	0.2	0.9	0.1	-0.4	0.3	-0.9	-0.2	0.4
Time employed in main current job	0.2	0.2	0.5	0.3	-0.7	0.0	-0.6	0.2	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.7	0.4	-0.9	0.5	0.8	-0.9
Gout (self-reported)	0.2	0.3	1.0	0.4	0.1	-1.0	-0.7	-0.4	-0.1
Medication: Amlodipine	0.2	0.3	0.9	-0.8	-0.6	-0.9	-0.1	0.3	0.1
Health satisfaction	0.2	0.3	1.2	0.4	-1.1	0.2	-0.5	0.0	-0.2
Alcohol intake frequency.	0.2	0.5	1.7	-1.3	0.5	-0.0	0.8	0.4	-0.2
Smoking status: Previous	0.2	0.3	0.6	0.4	0.7	-0.5	0.8	-0.6	-0.1
Leg fat-free mass (right)	0.2	1.0	2.7	1.0	1.1	0.1	0.9	-1.6	-0.0
Leg predicted mass (right)	0.2	1.0	2.7	1.1	1.2	0.1	0.9	-1.6	-0.1
Medication: Bendroflumethiazide	0.2	0.2	0.8	-0.3	-0.5	0.9	-0.1	0.2	0.5
Alcohol drinker status: Never	0.2	0.2	0.5	-0.6	0.1	0.1	0.3	0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.5	1.0	1.2	0.6	-0.6	0.5	-0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.5	0.2	0.2	-0.5	-0.0	-0.3
Systolic Blood Pressure	0.1	0.5	1.2	1.1	-0.5	-1.1	-0.0	-0.6	-0.2
Tanning	0.1	0.8	1.9	-0.2	1.4	-1.2	-0.2	-0.2	1.1
Systolic blood pressure, automated reading	0.1	0.3	0.8	0.5	-0.6	0.7	-0.9	-0.2	-0.2
Past tobacco smoking	0.1	0.2	0.4	-0.4	-0.4	0.6	-0.3	0.6	-0.2
Forced vital capacity (FVC)	0.1	0.3	1.7	0.2	-0.2	-0.4	-0.1	0.1	1.3
Pain all over the body in last month	0.1	0.1	0.6	0.8	-0.2	0.1	-0.1	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.1	1.1	0.4	0.0	-0.7	0.0	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.3	0.4	-0.1	-0.2	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	0.7	-0.1	0.3	-0.8	-0.3	0.0
High blood pressure (siblings)	0.1	0.1	0.3	0.1	-0.4	-0.3	-0.1	0.4	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	2.3	0.1	-0.5	0.5	-0.2	0.0	1.5
Hair Pigment	0.0	1.3	4.6	0.2	-1.6	0.5	-2.1	-0.5	-0.1
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.3	0.1	-0.1	0.2	0.1	0.2

Hub : Genes

SESN3

Models

Trait associations