Hub : Genes

SETD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0870	0.0470	0.00300	0.005	NA	0.023	NA	0.010	1.1e-01	NA	0.0049	NA	0.04600
2	GTEx	Stomach	0.0740	0.0380	0.00520	0.046	NA	0.001	NA	0.041	3.0e-03	NA	0.2700	NA	0.00480
3	TCGA	Breast Invasive Carcinoma	0.0211	0.0248	0.00420	0.010	0.008	0.011	NA	0.008	3.4e-03	0.0075	0.0016	NA	0.00760
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0610	0.0380	0.00012	0.065	0.035	0.037	NA	0.052	3.5e-05	0.0021	0.0016	NA	0.00021

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.7	2.7	4.0	-1.8	-2.0	0.0	1.9
Bipolar Disorder or Schizophrenia	0.8	2.0	4.5	-2.1	-1.0	0.0	1.7
Depressed Affect (Nagel 2018)	0.6	1.2	2.6	-0.8	-0.3	1.2	1.6
Depression (Nagel 2018)	0.3	0.5	0.7	-0.8	-0.7	0.4	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.5	-0.5	0.0	0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.4	0.6	0.2	0.7
Schizophrenia (2018)	0.3	0.5	1.6	-1.3	0.4	0.0	0.6
Schizophrenia vs Biploar Disorder	1.6	2.2	5.0	1.0	2.2	0.0	-1.6
Worry (Nagel 2018)	0.1	0.2	0.5	0.2	-0.2	0.6	0.7
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.7	-0.7	0.5	0.5
Alzheimer’s Disease (in father)	0.3	0.4	1.2	-1.1	-0.4	-0.2	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-0.9	-1.0	0.3	0.3
Crohns Disease (2017)	0.9	2.1	3.4	-1.1	-1.8	1.0	1.6
Irritable Bowel Disease (IBD)	0.2	0.6	1.6	-0.4	-1.3	-0.0	0.8
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.0	-0.6	-0.5	0.0
Major Depression (MDD)	0.4	0.5	1.8	1.4	0.5	0.0	-0.1
Reaction Time	9.7	18.4	26.7	2.3	5.2	-4.8	-4.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.2	-0.9	-1.1	0.9	1.1
Breast Cancer	0.6	1.4	4.5	-2.1	0.2	0.3	0.9
Ovarian Cancer	3.5	4.6	6.3	2.0	2.5	-2.0	-2.1
Prostate Cancer	0.3	0.5	0.7	0.6	0.6	0.8	0.7
Age at First Birth	1.6	2.4	4.1	0.2	1.7	-2.0	-1.5
Bipolar Disorder (2011)	1.7	1.6	6.6	0.0	0.0	0.0	2.6
Body Mass Index (BMI) (2010)	0.8	1.2	1.6	-1.1	-1.2	1.0	0.9
Coronary Artery Disease (CAD)	0.4	0.5	0.8	0.9	-0.2	-0.9	-0.6
Crohns Disease (2012)	1.5	2.4	4.6	-1.3	-2.1	0.0	1.8
Mean Putamen Volume	0.7	0.8	2.8	-1.7	-0.3	-0.6	-0.5
Fasting Glucose	0.5	0.7	1.2	-0.1	-0.5	1.1	1.1
HbA1C	1.6	1.8	2.8	1.3	1.7	-1.2	-1.2
HDL Cholesterol	3.5	5.9	7.1	-2.7	-2.1	2.4	2.5
LDL Cholesterol	0.1	0.2	0.5	-0.7	-0.3	0.2	-0.1
Lupus	0.9	1.4	2.0	-1.4	-0.4	-1.3	-1.4
Neuroticism (2016)	0.7	1.1	3.6	0.3	-0.8	0.0	1.9
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.5	-0.4	-0.4	-0.5
Rheumatoid Arthritis	0.7	0.9	2.2	1.5	0.2	-0.9	-0.8
Schizophrenia (2014)	0.1	0.1	0.5	-0.7	0.1	0.0	0.2
Triglycerides	1.7	2.8	4.0	1.2	1.6	-1.7	-2.0
Type 2 Diabetes (T2D) (2012)	8.7	10.1	13.7	3.7	2.6	-3.2	-3.1
Ulcerative Colitis	0.1	0.1	0.4	0.4	-0.1	0.0	-0.6
Blood Eosinophil Count	0.7	5.6	9.7	1.9	1.3	-2.8	-3.1
Blood Platelet Count	0.5	5.8	8.6	-1.0	-2.9	2.5	2.8
Blood Red Count	0.1	0.8	1.6	-1.3	1.0	0.6	-0.6
Blood White Count	17.0	125.7	151.3	8.4	11.6	-12.3	-12.1
Heel T-Score	4.1	32.8	52.9	3.8	4.1	-6.9	-7.3
BMI	0.8	4.6	6.1	-2.0	-1.6	2.4	2.5
Height	0.2	3.8	8.9	-0.9	1.9	-1.4	-3.0
Waist Hip Ratio (WHR)	8.8	39.6	46.8	5.5	5.9	-6.8	-6.8
Systolic Blood Pressure	1.7	8.5	15.6	0.8	2.6	-4.0	-3.3
Smoking Status	2.1	5.0	8.0	-1.5	-1.6	2.8	2.7
Allergy or Eczema	4.6	12.0	17.4	-2.2	-3.6	4.2	3.7
Cardiovascular Disease	0.9	3.0	4.6	2.1	1.6	-1.8	-1.2
Hypothyroidism (self reported)	0.8	1.8	4.6	0.5	-0.1	1.6	2.1
Respiratory disease	0.2	0.6	0.9	0.3	-0.9	1.0	0.6
Type 2 Diabetes (T2D) (2018)	6.6	12.3	17.1	4.1	3.0	-3.3	-3.5
Lung FEV1/FVC ratio	1.9	9.5	14.2	1.6	2.9	-3.5	-3.8
Lung FVC	0.2	1.2	2.1	0.8	-0.0	-1.4	-1.5
Neuroticism	0.5	1.2	2.9	0.2	-0.4	1.3	1.7
Chronotype (morning person)	1.6	3.8	6.7	1.1	2.0	-2.6	-1.8
Hair Pigment	0.1	3.2	4.5	-1.8	-2.1	1.9	1.4
Tanning	0.1	0.9	1.6	0.9	1.3	-0.5	-0.9
Hand grip strength (left)	2.1	5.6	8.6	-2.9	-2.6	2.1	1.6
Number of treatments/medications taken	0.5	0.9	2.3	-0.4	-0.1	1.0	1.5
Average weekly spirits intake	3.7	4.6	7.3	-2.7	-1.7	2.0	2.0
Sensitivity / hurt feelings	0.2	0.3	0.7	0.8	0.2	0.2	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.2	0.3	-0.5	-0.4
Hearing difficulty/problems: Yes	2.3	3.5	4.6	1.4	2.1	-2.2	-1.6
Relative age of first facial hair	0.1	0.1	0.2	-0.2	-0.2	0.4	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	-0.2	-0.2	0.9	1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	1.0	1.3	-0.3	-0.2
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	0.5	-0.5	1.4	1.3
Systolic blood pressure, automated reading	0.4	1.3	2.9	-1.7	0.8	-1.1	-0.6
Eye problems/disorders: Diabetes related eye disease	3.6	4.0	7.0	2.6	1.5	-1.7	-2.0
Angina	0.9	1.2	2.1	0.6	0.9	-1.2	-1.5
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	0.7	-0.1	-0.3
Vitamin and mineral supplements	13.1	17.7	18.2	4.1	4.2	-4.3	-4.2
Supplements: Zinc	1.3	1.4	2.1	-0.0	-1.5	1.4	1.3
Medication: Co-codamol	0.7	0.8	2.1	1.0	1.4	0.1	-0.1
Medication: Metformin	2.8	3.9	5.6	1.4	2.0	-2.4	-2.0
Diabetes (father)	2.4	2.9	3.6	1.9	1.6	-1.6	-1.7
Diabetes (mother)	5.0	6.4	9.4	1.4	2.4	-2.9	-3.1
Severe depression (siblings)	0.2	0.3	0.6	0.1	-0.5	0.5	0.8
Pack years adult smoking proportion	1.1	1.7	2.9	-0.4	1.7	-1.4	-1.3
Impedance of leg (right)	1.4	6.6	8.9	2.5	2.4	-2.4	-3.0
Leg fat-free mass (left)	0.3	1.6	2.7	-1.6	-0.8	1.4	1.0
Trunk fat percentage	0.2	0.9	2.0	-0.6	-0.6	1.4	0.9
Hand grip strength (right)	0.8	2.3	5.5	-2.3	-1.6	0.8	0.5
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.1	0.5	0.1	-0.2
Current tobacco smoking	0.1	0.2	0.3	-0.5	0.6	-0.3	-0.5
Average weekly fortified wine intake	3.0	3.5	6.6	-1.9	-2.6	1.3	1.4
Maternal smoking around birth	3.7	5.3	6.9	1.6	2.6	-2.3	-2.6
Fed-up feelings	0.5	1.0	1.7	-1.3	0.3	1.0	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	-0.4	-0.9	1.2	1.2
Relative age voice broke	0.4	0.6	0.8	-0.6	-0.8	0.7	0.9
Taking other prescription medications	0.2	0.3	0.9	0.9	0.7	-0.0	0.2
Age when periods started (menarche)	0.4	1.0	1.9	-0.7	-1.0	0.8	1.4
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	5.1	2.3	0.5	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	12.4	1.4	1.4	-3.1	-3.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.6	-0.8	0.2	0.0
Qualifications: CSEs or equivalent	1.8	2.4	3.8	0.6	1.8	-2.0	-1.5
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.2	0.5	0.7	0.9
High blood pressure	0.1	0.2	0.8	-0.0	0.0	0.4	0.9
Hayfever, allergic rhinitis or eczema	3.8	8.4	11.0	-1.8	-3.2	3.3	3.0
Multivitamins +/- minerals	10.9	13.8	14.7	-3.8	-3.6	3.8	3.7
Stomach or abdominal pain in last month	0.9	1.2	2.2	0.2	1.5	-1.1	-1.1
Supplements: Glucosamine	1.9	2.5	4.5	-1.2	-1.0	2.1	1.7
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	3.3	1.1	1.8	-1.6	-1.7
Medication: Atenolol	0.5	0.6	1.6	0.3	-1.2	0.5	0.7
Medication: Levothyroxine sodium	1.4	2.3	4.7	1.0	-0.7	1.8	2.2
Sitting height	0.1	0.5	0.9	-0.9	-0.0	0.9	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	2.7	0.4	1.6	-0.5	-0.3
High blood pressure (mother)	0.3	0.4	0.8	0.7	-0.9	0.2	0.7
Body mass index (BMI)	0.6	2.7	3.7	-1.6	-1.4	1.9	1.7
Impedance of leg (left)	1.4	7.0	10.0	2.3	2.4	-2.7	-3.2
Leg predicted mass (left)	0.3	1.6	2.7	-1.6	-0.8	1.4	1.0
Trunk fat mass	0.3	1.1	2.3	-1.0	-0.6	1.5	0.9
Waist circumference	0.1	0.2	0.4	0.6	0.5	-0.2	-0.5
Number of incorrect matches in round	1.1	1.8	3.8	-0.6	-0.8	1.6	1.9
Past tobacco smoking	2.8	5.2	9.1	1.1	1.3	-3.0	-2.9
Alcohol usually taken with meals	0.3	0.5	0.7	0.8	-0.7	0.7	0.7
Nervous feelings	0.3	0.5	0.9	0.3	-0.6	0.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.1	0.0	1.8	-1.3	-1.0
Hearing difficulty/problems with background noise	0.4	0.6	1.1	1.0	1.1	-0.6	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.2	0.8	-0.4	-0.8
Had menopause	0.7	0.9	1.3	-0.9	-0.4	1.1	1.0
Had other major operations	0.5	0.6	1.5	-0.7	-0.2	0.7	1.2
Forced vital capacity (FVC)	0.3	1.2	2.5	0.8	0.1	-1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	5.6	12.8	20.8	2.7	2.5	-4.1	-4.6
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	4.0	-1.2	-1.7	1.9	2.0
Qualifications: None of the above	1.5	3.2	5.2	-1.2	-1.2	2.3	2.2
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.5	0.0	-0.3	-0.1
Mouth/teeth dental problems	0.7	1.0	2.6	1.6	0.5	-1.0	-0.7
Heart attack	1.8	2.3	4.4	1.1	1.3	-1.3	-2.1
Allergy	2.8	6.5	11.0	1.2	3.3	-2.9	-2.2
Pain all over the body in last month	1.6	1.7	2.9	0.6	-1.1	1.7	1.5
Diabetes (self-reported)	3.7	5.6	9.0	3.0	1.5	-2.4	-2.3
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.0	-0.7	-1.2	2.0	1.6
Medication: Ramipril	0.1	0.1	0.3	0.1	-0.6	0.3	-0.0
Medication: Simvastatin	0.9	1.2	1.9	0.8	1.4	-1.3	-0.9
Fluid intelligence score	0.1	0.2	0.4	0.3	-0.5	0.3	0.6
Illnesses of siblings	0.2	0.3	0.5	0.1	-0.7	-0.4	-0.6
Neuroticism score	0.2	0.4	0.9	0.3	0.3	0.8	0.9
Weight	0.2	1.0	1.9	-1.4	-0.6	1.2	0.6
Impedance of arm (right)	0.2	1.0	2.1	1.5	0.6	-0.8	-1.0
Arm fat percentage (right)	0.6	2.3	3.9	-0.9	-1.4	2.0	1.6
Trunk fat-free mass	0.2	0.9	2.5	-1.6	-0.4	1.0	0.3
Hip circumference	2.0	8.5	12.0	-2.4	-2.7	3.5	2.9
Time employed in main current job	0.3	0.3	0.8	-0.9	-0.5	0.4	0.2
Alcohol intake versus 10 years previously	1.3	2.0	3.6	-0.5	-1.2	1.9	1.6
Father’s age at death	0.1	0.2	0.6	0.8	-0.3	-0.3	0.0
Worrier / anxious feelings	0.7	1.4	2.7	1.3	1.6	-0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	0.2	1.0	-0.6	-0.8
Falls in the last year	0.3	0.4	0.8	-0.9	0.4	0.8	0.4
Hair/balding pattern: Pattern 3	0.4	0.7	1.5	0.6	-0.2	-0.9	-1.2
Number of live births	0.5	0.7	1.2	0.0	1.1	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.2	1.6	0.7	-1.9	-2.3
Pulse rate	3.7	6.3	8.0	2.0	2.6	-2.5	-2.8
Happiness	1.2	1.5	3.0	-0.1	1.1	-1.7	-1.4
Noisy workplace	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.5	-0.1	-0.4	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.3	-0.3	-0.3	0.1
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	-1.4	-0.5	0.2	-0.0
Asthma	0.5	1.1	1.9	-0.3	-1.4	1.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.2	0.8	0.3	0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	0.1	1.2	-0.7	-0.6
Depression (self-reported)	4.2	5.0	7.0	-2.6	-2.0	1.9	2.3
Medication: Lansoprazole	7.3	8.3	9.5	2.5	3.1	-3.0	-2.9
Prospective memory result	0.2	0.3	0.5	-0.5	0.3	-0.7	-0.5
Lung cancer (father)	0.5	0.6	2.0	-1.4	0.6	0.2	0.1
Illnesses of mother	0.1	0.2	0.5	-0.7	0.2	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	7.7	1.5	1.2	-2.3	-2.8
Pulse wave Arterial Stiffness index	0.7	0.9	1.4	-0.2	0.8	-1.2	-1.1
Impedance of arm (left)	0.4	1.6	2.2	1.5	1.0	-1.3	-1.3
Arm fat mass (right)	0.5	1.9	3.2	-1.3	-1.1	1.8	1.3
Trunk predicted mass	0.1	0.7	2.1	-1.4	-0.3	0.8	0.1
Standing height	0.3	2.5	5.5	0.1	1.7	-1.3	-2.3
Length of working week for main job	0.2	0.2	0.4	-0.6	-0.1	-0.2	-0.5
Exposure to tobacco smoke at home	0.6	0.6	0.9	-0.9	-0.6	0.7	0.9
Breastfed as a baby	2.4	2.9	3.7	-1.8	-1.4	1.9	1.8
Tense / ‘highly strung’	0.3	0.4	1.3	0.3	1.1	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	5.0	-0.9	-0.9	2.2	2.2
Hair/balding pattern: Pattern 4	1.3	3.2	4.9	-1.6	-1.6	1.6	2.2
Birth weight of first child	1.9	3.5	5.2	-1.4	-1.9	2.3	1.7
Peak expiratory flow (PEF)	0.4	0.8	2.5	-0.0	-1.6	0.5	0.7
Pulse wave reflection index	2.6	3.2	4.1	-1.4	-1.9	1.8	2.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.3	-0.8	-1.5	1.5	1.3
Loud music exposure frequency	1.1	1.2	3.3	1.2	1.8	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.8	0.8	1.3	-2.0	-1.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	-1.0	0.3	-0.5	-0.3
Blood clot in the leg (DVT)	0.5	0.7	2.4	1.5	-0.2	-0.1	-0.5
Medication: Paracetamol	0.4	0.6	1.2	-0.9	0.0	1.1	0.7
Headache pain in last month	0.7	1.3	2.3	0.7	1.5	-0.8	-1.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.1	-0.8	0.4	0.4
Glaucoma (self-reported)	0.2	0.2	0.4	0.7	0.6	-0.2	0.3
Gout (self-reported)	0.4	0.6	1.2	0.5	1.1	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.7	1.0	0.0	1.6	1.9
Medication: Amlodipine	0.4	0.6	0.9	-0.3	0.6	0.9	1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.1	-0.5	0.0	0.3
Birth weight	4.3	9.3	12.2	-2.7	-3.0	3.5	3.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.2	0.7	-0.2	-0.5
High blood pressure (siblings)	0.3	0.4	0.7	-0.8	-0.4	0.5	0.6
Forced vital capacity (FVC), Best measure	0.8	2.9	6.0	1.0	1.0	-1.9	-2.5
Body fat percentage	0.2	1.0	2.1	-0.5	-0.7	1.5	0.9
Leg fat percentage (right)	0.3	1.0	2.3	-0.3	-0.9	1.5	0.9
Arm fat-free mass (right)	0.1	0.4	1.5	-1.2	0.1	0.3	-0.3
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.6	0.9	-0.2	-0.5
Comparative body size at age 10	3.1	8.7	9.1	-3.0	-2.8	2.9	3.0
Number of full brothers	0.6	0.8	2.5	-0.6	1.6	-0.4	-0.5
Worry too long after embarrassment	2.0	3.3	3.8	1.9	1.9	-1.9	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-0.9	-0.5	0.9	1.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.2	-1.5	-1.1	0.9	1.1
Number of children fathered	0.8	0.9	1.4	-1.0	0.6	-0.8	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.7	-0.2	0.2	0.2
Age at first live birth	0.3	0.5	0.9	0.7	0.1	-0.9	-0.7
Pulse wave peak to peak time	0.4	0.5	1.0	0.3	-0.5	1.0	0.8
Health satisfaction	0.3	0.4	1.2	-1.1	0.1	0.6	0.1
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.1	0.6	0.7	0.6
Qualifications: College or University degree	3.9	12.3	14.5	3.8	2.7	-3.8	-3.6
Eye problems/disorders: None of the above	0.4	0.5	1.5	-1.2	-0.1	0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	-1.0	-0.3	-0.1	-0.4
Emphysema/chronic bronchitis	0.3	0.3	1.1	-1.1	-0.1	0.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	0.7	-1.0	-0.7	-0.5
Neck or shoulder pain in last month	0.8	1.1	2.0	-0.2	1.1	-1.0	-1.4
Medication: Blood pressure	0.2	0.4	0.9	0.9	0.8	-0.0	0.2
Angina (self-reported)	1.4	1.8	3.0	0.8	1.1	-1.5	-1.7
Migraine (self-reported)	0.2	0.3	0.9	0.9	-0.1	0.2	0.4
Medication: Ibuprofen	0.5	0.6	1.1	-0.7	0.2	1.0	1.0
Medication: Allopurinol	0.4	0.6	1.5	-0.0	1.2	-0.7	-0.5
Medication: Omeprazole	0.4	0.5	0.7	-0.7	-0.6	0.7	0.8
Medication: Seretide 50 evohaler	3.2	3.6	5.1	-2.3	-1.5	2.0	1.8
Mean time to correctly identify matches	7.8	14.8	26.8	2.0	5.2	-4.0	-3.5
Heart disease (mother)	0.2	0.3	0.8	0.3	0.9	-0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	0.5	-0.5	0.6	0.5
Whole body fat mass	0.3	1.1	2.2	-1.0	-0.6	1.5	0.9
Leg fat mass (right)	0.2	0.8	1.6	-0.9	-0.6	1.3	0.6
Arm predicted mass (right)	0.1	0.5	1.7	-1.3	0.2	0.4	-0.2
Pulse rate, automated reading	1.8	5.8	6.9	2.4	2.6	-2.0	-2.6
Alcohol intake frequency.	0.1	0.2	0.5	0.7	-0.2	0.3	-0.5
Comparative height size at age 10	0.4	2.0	4.7	0.0	1.5	-1.1	-2.2
Number of full sisters	0.8	1.0	3.7	-1.9	0.2	0.1	0.5
Suffer from ‘nerves’	1.1	1.7	4.0	0.2	-0.6	1.6	2.0
Overall health rating	0.6	1.3	3.9	0.1	2.0	-0.9	-0.8
Chest pain or discomfort	0.4	0.6	0.9	0.1	0.9	-0.9	-0.9
Had major operations	0.1	0.1	0.2	-0.4	0.5	0.2	0.3
Age at last live birth	0.0	0.0	0.1	-0.0	-0.3	-0.1	-0.1
Family relationship satisfaction	0.7	0.9	1.5	-1.2	0.7	-1.2	-0.5
Leg pain on walking	1.2	1.6	2.7	-0.0	1.5	-1.1	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	-0.3	0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	-0.1	-0.1	0.9	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.2	-0.7	0.5	0.6
Medication: Aspirin	0.8	1.0	2.5	0.3	1.6	-1.0	-0.8
Supplements: Vitamin C	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.1
Knee pain experienced in last month	1.5	2.4	3.8	1.0	1.8	-1.2	-1.9
Hypertension (Self-reported)	0.0	0.1	0.4	0.3	0.0	0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.1	-0.2	-0.6
Illnesses of father: Heart disease	0.9	1.2	2.9	1.7	-1.3	0.5	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.3	0.5	0.2	-0.1
Smoking status: Previous	3.0	4.5	7.9	-0.7	-1.3	2.8	2.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.8	-1.8	0.4	-1.1	-1.9
Whole body fat-free mass	0.2	1.1	2.5	-1.6	-0.6	1.1	0.5
Leg fat-free mass (right)	0.3	1.7	3.1	-1.8	-0.9	1.4	1.0
Arm fat percentage (left)	0.5	1.9	2.9	-0.9	-1.3	1.7	1.4
Average weekly red wine intake	0.2	0.3	0.6	0.8	-0.7	-0.0	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.3	-0.6	0.2	0.2
Mood swings	0.2	0.3	1.0	0.2	1.0	0.2	0.4
Loneliness, isolation	0.3	0.4	0.7	0.5	0.7	0.4	0.9
Long-standing illness, disability or infirmity	0.6	0.9	1.9	1.3	1.4	-0.3	-0.3
Ever had bowel cancer screening	0.5	0.5	1.1	0.9	1.0	-0.3	0.4
Diabetes diagnosed by doctor	4.5	7.4	8.4	2.9	2.3	-2.8	-2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	0.0	0.5	0.3
Friendships satisfaction	1.9	2.3	3.3	0.5	1.8	-1.8	-1.6
Qualifications: nursing, teaching	0.1	0.1	0.5	0.3	0.1	0.1	0.7
Commuting to job workplace: Walk	0.3	0.3	0.7	0.8	-0.6	-0.4	0.2
Eye problems/disorders: Cataract	1.0	1.2	1.7	0.8	-1.1	1.0	1.3
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	6.1	-1.5	-1.7	2.5	1.9
Medication for cholesterol	0.6	1.0	1.9	-1.4	-1.0	0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.1	-0.6	0.7	0.8
Back pain experienced in last month	0.4	0.5	1.9	-0.3	1.4	-0.4	-0.2
Mineral and other dietary supplements	3.1	4.2	4.8	2.0	1.8	-2.2	-2.2
Breast cancer (self-reported)	1.3	1.5	2.5	-1.2	-0.5	1.4	1.6
Asthma (self-reported)	0.6	1.1	2.1	-0.4	-1.5	1.3	0.8
Osteoporosis (self-reported)	0.3	0.4	1.0	-0.3	0.1	0.6	1.0
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.1	0.6	0.1	-0.5
Medication: Aspirin	0.7	0.9	1.4	0.7	1.2	-1.0	-0.9
Medication: Gliclazide	1.5	1.6	2.8	1.4	0.7	-1.7	-1.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	-1.0	0.3	-0.2	-0.2
Smoking status: Current	0.1	0.2	0.4	-0.6	0.5	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.3	0.9	-0.2	-1.4	-1.5
Whole body water mass	0.2	0.9	2.3	-1.5	-0.4	1.1	0.4
Leg predicted mass (right)	0.3	1.7	3.2	-1.8	-0.9	1.3	1.0
Arm fat mass (left)	0.3	1.2	2.2	-1.0	-0.8	1.5	1.0
Number of self-reported non-cancer illnesses	0.4	0.8	1.9	1.4	0.5	0.7	0.5
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.3	-0.6	0.5	0.8
Miserableness	0.4	0.6	1.3	-0.6	0.2	1.1	0.9
Guilty feelings	0.6	0.9	1.1	-0.8	-0.8	1.1	1.0
Wears glasses or contact lenses	0.6	0.7	0.9	0.8	-0.8	0.9	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.4
Hearing aid user	1.0	1.1	1.7	-0.9	0.8	-1.1	-1.3
Mother’s age at death	1.1	1.3	3.3	1.8	0.7	-1.1	-0.5
Financial situation satisfaction	4.1	5.1	8.8	0.4	1.9	-2.8	-3.0
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.7	1.5	0.8	-1.6	-1.4
Commuting to job workplace: Public transport	0.7	0.8	1.5	-0.4	-0.3	1.2	1.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	1.0	0.6	-0.6	-0.2
Medication: Blood pressure	0.2	0.3	0.9	0.3	-0.4	0.1	1.0
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.5	0.7	2.1	-1.0	-1.4
Supplements: Fish oil (including cod liver oil)	3.1	4.0	5.6	-1.2	-1.9	2.4	2.4
High cholesterol (Self-reported)	0.9	1.5	2.4	1.1	1.5	-1.3	-1.0
Medication: Bendroflumethiazide	0.6	1.0	1.9	0.9	-0.1	1.1	1.4
Medication: Paracetamol	0.3	0.5	1.0	-0.5	-0.3	1.0	0.8
Medication: Lisinopril	1.6	2.1	4.3	2.1	1.7	-1.1	-0.0
Medication: Atorvastatin	0.3	0.3	0.5	0.7	0.7	-0.7	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.3	-0.1	0.3	-0.5	-0.6
Alcohol drinker status: Never	1.0	1.2	2.2	-0.3	1.0	-1.2	-1.5
Ever smoked	4.2	7.4	12.3	-1.4	-1.8	3.5	3.5
Basal metabolic rate	0.2	1.2	2.8	-1.7	-0.6	1.2	0.5
Leg fat percentage (left)	0.3	1.1	2.3	-0.5	-1.0	1.5	1.0
Arm fat-free mass (left)	0.1	0.4	1.2	-1.1	0.1	0.7	-0.1
Number of operations (self-reported)	0.4	0.6	1.9	-0.0	1.4	0.4	0.7
Average weekly beer plus cider intake	0.3	0.4	1.6	-0.4	1.3	-0.2	-0.1
Irritability	0.3	0.5	1.4	0.1	1.2	-0.7	0.0
Risk taking	0.8	1.2	2.0	0.8	1.2	-0.8	-1.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	-0.3	-0.6	0.4	0.0
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.0	-0.3	0.4	0.9
Age started oral contraceptive pill	0.7	0.8	2.1	-1.4	-1.0	0.2	0.4
Diastolic blood pressure, automated reading	0.5	1.6	2.6	-1.0	1.6	-1.3	-1.1
Ever depressed for a whole week	2.0	2.4	4.6	-0.8	-1.2	1.7	2.1
Unable to work because of sickness or disability	0.3	0.4	1.5	0.0	1.2	0.2	0.4
Commuting to job workplace: Cycle	1.1	1.3	2.0	1.3	1.4	-1.1	-0.8
Myopia	3.4	5.0	8.4	-1.1	-2.2	2.4	2.9
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.1	-0.1	-0.2	-0.6
Cholesterol lowering medication	2.7	4.0	5.3	1.7	2.1	-2.3	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.5	-0.0	0.5	0.5
Pain experienced in last month	0.9	1.5	3.1	-0.7	-1.8	0.8	1.2
Supplements: Calcium	1.1	1.2	1.8	-0.6	-1.2	1.1	1.4
Basal cell carcinoma (self-reported)	1.2	1.4	2.0	-1.3	-1.4	0.9	1.1
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.6	1.1	1.3	-1.1	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	1.3	0.1	-0.2	-0.6
Heart disease (siblings)	0.5	0.6	1.3	0.3	-0.3	0.9	1.2
Alcohol drinker status: Previous	1.8	2.1	3.6	0.1	-1.6	1.9	1.5
Pack years of smoking	0.9	1.3	2.3	-0.3	1.5	-1.2	-1.2
Impedance of whole body	1.0	5.0	6.4	2.0	2.0	-2.3	-2.5
Leg fat mass (left)	0.2	0.7	1.4	-0.9	-0.6	1.2	0.6
Arm predicted mass (left)	0.1	0.6	1.8	-1.3	-0.1	0.7	0.0