Hub : Genes

SFRP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1690	0.0410	1.8e-06	0.037	0.045	0.055	0.068	0.055	2.4e-05	3.4e-06	2.7e-07	9.8e-09	3.0e-07
2	GTEx	Artery Tibial	0.0825	0.0293	2.3e-03	0.023	NA	-0.003	NA	0.013	5.9e-03	NA	6.6e-01	NA	3.2e-02
3	GTEx	Muscle Skeletal	0.0671	0.0309	7.4e-03	-0.002	NA	0.000	NA	0.002	5.6e-01	NA	3.2e-01	NA	1.8e-01
4	METSIM	Adipose	0.0757	0.0256	1.0e-04	0.044	0.028	0.012	0.028	0.032	3.0e-07	4.4e-05	5.1e-03	3.7e-05	1.2e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.2798	0.0477	8.6e-12	0.135	0.132	0.168	0.158	0.148	5.9e-17	1.1e-16	5.2e-21	9.6e-20	1.5e-18
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0719	0.0325	1.1e-03	0.008	0.013	0.019	NA	0.032	3.4e-02	1.0e-02	3.0e-03	NA	1.6e-04
7	TCGA	Lung Adenocarcinoma	0.0645	0.0363	7.4e-03	0.022	0.016	0.010	NA	0.012	1.2e-03	5.0e-03	2.1e-02	NA	1.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.3	2.9	1.7	-1.0	-1.1	1.3	1.5	0.0	-0.4
Bipolar Disorder or Schizophrenia	0.7	1.6	4.2	0.9	-1.0	-0.5	1.6	1.4	2.1	0.7
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	0.5	-0.2	0.7	-0.7	-0.0	-1.5	-0.9
Depression (Nagel 2018)	0.4	0.6	1.8	-0.3	0.2	-0.6	-0.1	-0.7	-1.4	-1.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	-0.9	-0.2	-0.8	0.2	-0.2	0.8	-1.1
Neuroticism (Nagel 2018)	0.7	1.6	3.7	-0.6	-1.5	-1.6	-0.1	-1.2	-0.7	-1.9
Schizophrenia (2018)	0.2	0.4	1.0	-0.3	-0.5	0.3	1.0	0.1	0.2	1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	2.9	-1.2	0.5	0.3	-0.3	-1.2	-1.7	0.4
Worry (Nagel 2018)	1.4	2.9	7.3	-1.2	-1.7	-2.3	0.7	-1.5	-0.9	-2.7
Alzheimer’s Disease (in mother)	1.0	1.1	3.7	-1.8	0.3	-0.1	-0.0	-1.9	-0.3	1.0
Alzheimer’s Disease (in father)	1.0	1.0	2.4	-0.9	1.3	1.6	-0.3	-0.8	1.0	0.8
Alzheimer’s Disease (including proxy)	1.0	1.5	4.3	-2.0	0.8	1.0	0.4	-2.1	0.2	0.6
Crohns Disease (2017)	0.7	1.5	5.9	0.8	0.6	1.0	-2.4	0.8	-0.7	-1.1
Irritable Bowel Disease (IBD)	0.9	2.1	5.4	0.2	0.6	1.4	-2.3	0.8	-1.7	-1.8
Ulcerative Colitis (UC)	0.5	1.0	2.9	-0.4	0.3	0.8	-1.1	0.4	-1.7	-1.3
Major Depression (MDD)	0.5	0.6	3.4	0.1	-0.2	-0.2	-0.2	-0.3	-0.5	-1.8
Reaction Time	0.5	1.0	2.7	-0.1	1.5	0.7	-0.3	1.0	1.6	-0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.6	-0.6	0.1	0.0	-0.1	-0.2	0.8	-2.1
Breast Cancer	0.6	1.5	7.3	0.4	2.7	0.7	-1.3	0.4	-0.7	-0.7
Ovarian Cancer	1.2	1.5	3.5	-1.7	1.8	0.1	-0.2	-1.9	0.5	0.9
Prostate Cancer	0.9	1.2	3.5	0.6	-1.9	-1.7	1.1	0.1	-0.7	0.3
Age at First Birth	0.7	1.0	4.7	0.1	0.5	-2.2	-0.3	0.0	-1.3	-0.8
Bipolar Disorder (2011)	0.3	0.3	1.0	-0.5	-0.7	-0.6	1.0	0.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.4	-1.9	0.5	1.4	-0.1	-1.0	0.6	0.7
Coronary Artery Disease (CAD)	1.9	2.2	9.1	-0.2	-1.3	-0.9	3.0	-1.0	-1.8	0.2
Crohns Disease (2012)	0.7	1.1	3.0	1.7	-0.1	0.6	-1.1	1.2	0.0	-1.2
Mean Putamen Volume	0.9	1.0	3.7	0.8	-1.1	-1.9	0.9	0.4	-0.4	-0.6
Fasting Glucose	0.6	0.7	2.4	-1.4	-0.3	0.5	0.8	-1.6	0.1	-0.2
HbA1C	1.4	1.6	3.6	0.8	-1.4	-1.7	1.9	-0.5	0.5	-1.1
HDL Cholesterol	0.6	1.0	2.8	1.7	0.2	0.6	1.2	0.8	1.0	0.6
LDL Cholesterol	0.4	0.6	3.0	-0.3	0.1	-0.2	-0.4	-1.0	-0.1	1.7
Lupus	0.8	1.3	6.6	-0.4	0.2	-0.2	0.5	-0.0	2.6	1.4
Neuroticism (2016)	0.9	1.3	4.2	0.9	-1.5	-1.1	-0.1	-0.2	-0.8	-2.0
Primary Biliary Cirrhosis	0.6	0.8	2.3	1.5	-0.7	-1.1	-0.2	0.3	0.9	0.8
Rheumatoid Arthritis	0.8	1.2	2.4	1.3	1.4	0.3	-0.6	1.6	-1.0	0.8
Schizophrenia (2014)	0.3	0.7	2.1	-0.7	-0.6	-1.1	1.4	-0.3	-0.2	0.5
Triglycerides	0.5	0.8	3.2	-1.1	0.5	0.3	-1.8	-0.2	-0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	-0.7	0.3	1.1	0.4	-0.6	-0.4	-0.6
Ulcerative Colitis	0.6	0.8	2.3	0.8	-0.5	0.8	-0.4	0.8	-1.5	-1.1
Blood Eosinophil Count	0.1	0.7	1.8	1.2	-1.2	-1.3	0.1	-0.2	-0.5	0.5
Blood Platelet Count	0.2	1.9	3.8	-1.3	-1.5	-0.9	1.4	-1.9	-0.9	1.3
Blood Red Count	0.5	4.5	20.1	-4.5	-1.4	-0.5	0.5	-2.6	-1.2	-0.8
Blood White Count	0.1	0.7	3.2	0.1	-0.3	0.1	0.3	-1.8	-1.0	0.6
Heel T-Score	0.7	5.4	11.4	-1.2	-3.1	-1.6	3.4	-1.5	1.9	2.5
BMI	0.8	4.9	13.7	-3.7	-1.8	-2.3	1.7	-2.8	-1.0	-0.7
Height	0.4	8.1	39.2	-1.1	1.9	0.5	-1.4	-2.1	6.3	2.6
Waist Hip Ratio (WHR)	0.5	2.5	6.2	-1.9	-1.4	-0.4	0.5	-2.5	-2.2	-0.7
Systolic Blood Pressure	0.1	0.6	1.8	1.4	0.3	0.2	1.2	0.8	-0.3	0.1
Smoking Status	0.4	0.9	2.3	0.7	-0.6	-1.1	0.8	0.2	-1.2	-1.5
Allergy or Eczema	0.7	1.8	5.7	2.4	1.2	0.7	-0.6	1.4	-1.2	-1.1
Cardiovascular Disease	0.9	2.8	7.8	-1.3	-1.6	-1.2	2.3	-2.8	-0.1	-0.9
Hypothyroidism (self reported)	0.4	0.9	2.0	-1.4	1.3	0.3	-0.4	-0.8	-0.3	1.4
Respiratory disease	0.5	1.1	2.0	-0.1	-1.4	-1.2	1.3	-0.2	1.4	-0.7
Type 2 Diabetes (T2D) (2018)	0.7	1.2	2.5	-1.0	-1.2	-1.6	0.2	-1.0	0.6	-1.5
Lung FEV1/FVC ratio	0.8	4.2	12.7	0.3	1.9	1.8	-3.6	0.5	-3.1	-0.2
Lung FVC	0.3	1.4	3.8	-0.2	1.2	1.9	-1.4	-0.4	-1.5	0.5
Neuroticism	0.5	1.2	4.2	0.4	-2.1	-0.7	0.1	-0.7	-0.5	-1.7
Chronotype (morning person)	0.5	1.2	3.8	-0.6	1.8	-0.3	-1.9	0.2	0.9	-0.2
Hair Pigment	0.0	1.2	3.2	0.8	-0.8	-1.6	-0.7	-0.0	0.9	-1.8
Tanning	0.1	1.8	4.8	1.0	-1.5	-1.9	2.2	-0.4	0.5	0.5
Hand grip strength (left)	0.2	0.5	1.4	-1.1	0.4	1.2	0.5	-0.4	0.4	0.5
Number of treatments/medications taken	1.3	2.3	5.4	-1.3	-1.4	-2.1	0.7	-2.3	1.4	-0.5
Average weekly spirits intake	0.8	1.0	2.5	0.5	-1.6	-1.3	1.4	-0.3	0.1	-0.4
Sensitivity / hurt feelings	0.7	1.2	4.5	0.2	-1.4	-1.1	-0.6	-0.6	-0.0	-2.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	-0.3	-0.3	-0.5	0.4	-0.8	-1.0	-1.6
Hearing difficulty/problems: Yes	0.6	0.9	1.9	-1.0	-0.9	-1.0	-0.2	-1.4	0.4	-1.1
Relative age of first facial hair	0.4	0.9	3.2	1.8	0.2	-1.2	1.0	0.4	0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.2	-0.4	1.8	0.1	-1.6	-0.0	0.5	1.0
Ever used hormone-replacement therapy (HRT)	1.3	1.7	7.3	-0.9	-1.6	-2.7	0.1	0.1	0.8	-0.7
Ever had hysterectomy (womb removed)	1.5	1.7	4.0	1.1	-2.0	-1.4	1.6	1.0	0.9	-0.2
Systolic blood pressure, automated reading	0.1	0.4	0.9	0.7	0.1	0.4	0.8	0.0	0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.5	0.8	0.2	-0.5	0.6	1.0	-0.6
Angina	0.7	0.9	3.6	-0.1	-1.1	-1.9	0.5	-1.1	-0.4	-0.2
Medication for hormone replacement therapy	0.4	0.4	1.8	-0.3	-0.3	0.9	-1.4	0.0	-0.3	0.3
Vitamin and mineral supplements	0.3	0.4	1.1	-0.3	-0.9	0.2	0.4	-0.7	-1.1	0.1
Supplements: Zinc	0.7	0.8	2.4	-0.8	-0.8	-1.1	-0.3	-1.6	-0.3	0.6
Medication: Co-codamol	1.8	2.1	8.0	-1.9	-0.4	-1.0	-0.3	-2.8	1.1	-0.6
Medication: Metformin	1.0	1.4	2.2	-1.4	-1.4	-1.5	0.3	-1.3	1.4	-0.1
Diabetes (father)	0.8	1.0	2.1	-0.0	1.1	1.0	-0.6	0.8	-1.2	-1.5
Diabetes (mother)	0.3	0.4	1.3	-0.4	-1.1	0.1	0.6	-0.0	0.7	-0.8
Severe depression (siblings)	0.3	0.3	0.9	-0.0	-0.2	-0.4	-0.6	-0.5	-1.0	0.5
Pack years adult smoking proportion	0.3	0.5	1.2	0.7	0.4	-0.3	0.4	0.6	-0.8	1.1
Impedance of leg (right)	0.1	0.6	1.6	-0.6	-1.3	0.3	-0.6	-1.1	-0.5	0.4
Leg fat-free mass (left)	0.3	1.4	3.2	-1.3	1.7	1.0	-0.1	-0.6	1.8	0.8
Trunk fat percentage	0.8	3.0	9.6	-3.1	-0.9	-1.0	1.3	-2.7	0.4	-0.2
Hand grip strength (right)	0.4	1.0	3.6	-1.9	0.7	1.1	0.4	-1.0	0.4	0.9
Townsend deprivation index at recruitment	0.7	0.9	2.3	0.4	-1.0	-0.8	1.1	0.5	-1.5	-0.9
Current tobacco smoking	0.4	0.6	1.9	0.6	-0.2	-0.4	-0.1	-0.3	-1.3	-1.4
Average weekly fortified wine intake	0.5	0.6	1.3	1.1	0.2	-0.8	-0.4	0.8	1.1	0.0
Maternal smoking around birth	0.6	0.9	2.2	1.4	-0.8	0.5	0.9	1.5	0.0	-0.8
Fed-up feelings	0.4	0.8	1.7	0.2	-0.6	-0.6	-0.8	-0.8	-1.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.8	-1.1	-0.2	-0.3	-0.3	-1.7	-0.9	-1.5
Relative age voice broke	1.7	2.7	6.3	1.8	-1.7	-2.2	2.5	0.8	0.8	-0.1
Taking other prescription medications	0.4	0.6	1.0	-0.9	-1.0	-0.8	1.0	-0.7	0.2	-0.1
Age when periods started (menarche)	0.8	1.8	4.8	-1.5	-1.1	-0.8	-0.2	-2.2	-1.7	-1.0
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	6.4	0.2	-2.5	-1.6	1.9	1.3	0.8	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.2	-1.2	-2.1	-1.8	2.0	-1.2	0.0	0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	5.7	0.0	-1.3	-1.2	1.0	-0.1	0.6	-2.4
Qualifications: CSEs or equivalent	0.7	0.9	2.1	1.0	-0.9	0.9	1.4	1.3	0.6	-0.1
Serious illness, injury or assault to yourself	0.7	0.8	3.5	0.0	-0.4	-1.9	0.3	0.1	-1.3	-0.4
High blood pressure	1.6	4.5	9.7	-1.5	-2.2	-2.7	1.8	-3.1	-0.1	-1.9
Hayfever, allergic rhinitis or eczema	0.8	1.8	8.4	2.9	0.6	0.8	-0.4	1.6	-0.5	-0.2
Multivitamins +/- minerals	0.4	0.5	1.5	-1.2	0.6	0.3	0.5	-0.6	0.8	0.1
Stomach or abdominal pain in last month	1.3	1.6	5.2	-1.1	-1.6	-2.3	1.2	-0.8	-0.2	-0.6
Supplements: Glucosamine	0.5	0.6	1.7	0.6	0.6	-0.6	-0.7	0.7	0.6	-1.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	-0.0	0.2	-1.0	0.5	-0.5	-0.7	0.2
Medication: Atenolol	1.2	1.5	6.2	-0.5	-1.1	-2.5	1.0	-1.2	0.4	0.4
Medication: Levothyroxine sodium	0.3	0.6	1.1	-0.7	-0.8	0.9	1.0	0.5	-0.2	0.7
Sitting height	1.4	10.2	31.5	-0.4	3.1	4.2	-2.1	0.3	5.6	2.9
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	-1.5	0.4	0.3	0.4	-1.1	0.3	1.0
High blood pressure (mother)	2.0	2.8	6.6	2.0	-2.5	-0.9	2.6	0.2	-1.4	-0.5
Body mass index (BMI)	0.4	1.8	4.4	-2.1	-0.9	-1.3	1.2	-1.8	-0.4	-0.6
Impedance of leg (left)	0.1	0.6	3.4	-0.3	-1.8	-0.0	0.4	-0.7	-0.7	-0.0
Leg predicted mass (left)	0.3	1.4	3.1	-1.3	1.8	1.1	-0.2	-0.6	1.8	0.7
Trunk fat mass	0.5	2.2	7.9	-2.8	-0.2	-0.6	0.8	-2.3	0.9	-0.2
Waist circumference	0.6	2.3	6.3	-2.5	-0.9	-0.8	0.9	-2.5	-0.9	-0.6
Number of incorrect matches in round	0.6	1.0	2.2	-0.9	1.5	1.2	-0.4	0.2	1.2	1.0
Past tobacco smoking	0.2	0.4	1.0	0.4	0.4	0.9	-0.9	0.1	-0.2	1.0
Alcohol usually taken with meals	0.3	0.5	2.0	-0.3	0.5	0.7	-0.4	1.4	0.2	-0.3
Nervous feelings	0.7	1.3	4.6	0.5	-0.4	-1.2	-1.0	-0.5	-2.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	-1.4	-0.5	-0.6	-0.4	-0.5	0.6	-1.0
Hearing difficulty/problems with background noise	0.8	1.3	4.2	-0.3	-0.7	-2.0	0.9	-0.9	-0.4	-1.5
Hair/balding pattern: Pattern 2	1.9	2.4	6.1	-0.8	1.6	1.6	-1.2	-0.9	-1.6	2.5
Had menopause	0.5	0.6	2.5	0.7	0.5	-1.6	-0.5	-0.0	0.9	-0.1
Had other major operations	0.4	0.5	1.6	0.3	-0.4	-1.3	0.8	-0.1	0.5	-0.9
Forced vital capacity (FVC)	0.5	1.9	8.0	-0.7	1.8	2.8	-1.0	0.1	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.0	-1.1	-2.4	-1.6	1.6	-0.9	1.9	1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.7	0.8	-0.1	-0.3	-1.0	0.1	0.1
Qualifications: None of the above	0.6	1.3	2.7	-1.7	0.4	0.5	-0.2	-1.2	1.6	1.4
Financial difficulties in last 2 years	0.6	0.8	2.0	-1.0	-0.6	-1.4	-0.4	-1.3	-0.8	-0.1
Mouth/teeth dental problems	0.6	0.9	2.2	0.2	0.3	1.4	0.1	0.8	1.5	1.0
Heart attack	2.3	2.9	7.7	1.9	-1.0	-2.8	0.1	1.5	0.5	-2.4
Allergy	0.3	0.7	2.5	-1.6	0.6	0.1	-0.8	-0.5	-0.9	-0.3
Pain all over the body in last month	1.6	1.8	3.7	1.8	-0.9	-0.8	0.9	1.9	0.2	-1.7
Diabetes (self-reported)	1.5	2.3	3.6	-1.9	-1.8	-1.7	0.5	-1.3	1.9	-0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	1.1	0.7	-0.2	0.5	0.8	-0.7	1.0
Medication: Ramipril	0.5	0.6	2.9	0.1	0.5	-1.7	0.4	-0.7	0.3	-0.5
Medication: Simvastatin	1.2	1.7	3.7	-1.4	0.0	1.9	0.1	-1.5	1.6	1.2
Fluid intelligence score	0.4	0.9	4.3	-0.1	-0.5	-0.9	0.4	0.1	-1.0	-2.1
Illnesses of siblings	1.0	1.4	2.6	1.6	-0.3	0.9	1.5	1.1	-0.2	1.5
Neuroticism score	0.4	0.9	2.9	0.9	-0.6	0.3	-1.1	0.4	-0.6	-1.7
Weight	0.3	1.3	4.3	-2.1	0.4	-0.1	0.6	-1.5	1.3	0.0
Impedance of arm (right)	0.2	0.7	2.4	-0.2	-1.6	-0.6	1.4	0.1	0.5	-0.4
Arm fat percentage (right)	0.7	2.8	6.5	-2.6	-1.6	-1.7	1.7	-1.9	0.4	-0.6
Trunk fat-free mass	0.3	1.7	6.2	-0.5	1.9	1.0	-0.8	-0.1	2.5	0.8
Hip circumference	0.2	1.0	3.1	-1.8	-0.4	-0.6	1.0	-1.5	0.2	-0.1
Time employed in main current job	0.4	0.5	1.3	0.5	1.1	-0.2	-0.2	0.8	0.9	-0.3
Alcohol intake versus 10 years previously	1.4	2.1	6.8	-2.6	-0.4	0.1	0.3	-1.7	-2.0	-0.7
Father’s age at death	0.8	1.1	3.9	1.2	0.8	-0.0	-1.4	2.0	0.1	0.2
Worrier / anxious feelings	1.1	2.0	7.4	-0.2	-2.0	-1.2	0.6	-0.7	0.2	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.3	-1.5	0.1	0.2	-0.6	-1.5	-1.2	-1.2
Falls in the last year	2.7	3.6	9.0	-2.2	-1.1	-2.2	1.1	-3.0	-1.9	-1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.9	0.0	-1.1	-1.4	0.5	0.0	0.8	-0.6
Number of live births	0.9	1.3	5.7	0.3	-0.7	-2.4	1.0	-1.2	-0.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	8.6	-1.0	1.3	2.9	-1.5	0.2	-0.9	0.6
Pulse rate	0.1	0.2	0.8	-0.9	0.3	0.2	-0.1	-0.4	0.2	-0.6
Happiness	1.2	1.4	3.7	-0.7	1.1	-0.1	-1.9	-1.3	-1.6	-0.5
Noisy workplace	0.3	0.3	0.9	0.4	-0.7	-0.4	0.8	-0.1	-1.0	-0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.8	2.2	0.9	-1.4	-1.2	1.8	-1.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.8	-1.0	-0.3	-1.7	0.4	-1.2	-0.4	-1.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.7	-0.4	1.4	1.6	-1.6	-0.6	-1.0	0.3
Asthma	0.6	1.2	2.7	-0.6	-1.1	-1.2	0.7	-0.6	1.6	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.9	-0.0	-0.8	-1.0	0.5	-0.6	-0.9
Medication: Cholesterol lowering	1.7	2.6	8.4	-2.9	0.4	0.4	-0.6	-2.8	0.8	0.7
Depression (self-reported)	0.6	0.7	1.3	-0.8	-0.1	-0.7	0.5	-1.1	-1.1	-1.0
Medication: Lansoprazole	0.3	0.3	0.8	-0.6	0.3	-0.6	0.2	-0.9	0.7	0.1
Prospective memory result	0.6	0.7	2.4	-0.2	1.6	0.4	-0.3	-0.5	-0.1	1.4
Lung cancer (father)	0.8	0.9	3.6	0.9	1.1	0.2	-1.9	0.4	0.4	0.7
Illnesses of mother	0.5	0.6	2.5	-0.3	0.6	0.3	-0.6	1.6	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	9.4	-1.1	1.0	3.1	-1.4	0.1	-1.5	0.1
Pulse wave Arterial Stiffness index	1.5	1.8	3.8	-1.4	1.5	2.0	-1.4	-0.3	-1.3	0.8
Impedance of arm (left)	0.1	0.4	1.1	-0.1	-1.0	-0.2	0.8	0.2	0.9	0.0
Arm fat mass (right)	0.4	1.7	5.3	-2.3	-0.6	-1.1	1.1	-1.8	0.7	-0.3
Trunk predicted mass	0.3	1.7	6.0	-0.5	1.8	1.0	-0.8	-0.1	2.5	0.8
Standing height	0.6	5.9	17.0	-0.1	3.2	3.0	-1.5	0.6	4.1	1.5
Length of working week for main job	1.4	1.6	4.5	2.0	0.9	0.6	0.1	2.1	1.0	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	0.2	-0.4	0.5	0.2	-0.0	-0.4
Breastfed as a baby	0.1	0.2	0.4	-0.2	0.4	0.1	-0.7	-0.6	-0.5	-0.1
Tense / ‘highly strung’	0.6	1.0	2.0	-1.4	0.4	-0.8	-1.2	-1.4	-0.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	7.8	-0.2	-1.7	-2.2	1.8	-0.2	-1.0	-2.8
Hair/balding pattern: Pattern 4	0.8	2.0	5.6	-0.4	-2.1	0.2	2.4	-0.5	1.7	0.5
Birth weight of first child	0.6	1.0	2.2	0.2	1.3	1.3	-0.2	0.8	-1.0	-1.5
Peak expiratory flow (PEF)	0.3	0.8	2.1	-0.0	0.2	1.4	-1.4	1.0	0.6	-0.2
Pulse wave reflection index	1.2	1.5	3.3	0.4	1.1	1.8	-1.8	1.1	-1.1	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	-0.3	1.0	1.3	-0.6	-0.4	-1.3	-0.5
Loud music exposure frequency	2.2	2.4	6.8	-0.1	-2.6	-1.3	1.8	0.5	2.2	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.6	1.1	1.4	1.6	-1.4	1.3	-0.5	1.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.6	0.2	-0.6	-1.6	0.4	-0.6	1.1	1.4
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.7	0.3	-0.3	0.3	-1.0	0.9	0.4
Medication: Paracetamol	1.1	1.8	4.0	1.4	-0.8	-0.3	1.3	1.6	-1.2	-2.0
Headache pain in last month	1.1	2.0	7.4	-1.5	-1.4	0.3	0.4	-2.7	-1.3	0.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.7	2.6	-0.5	0.0	0.3	2.3	-0.4	1.2
Glaucoma (self-reported)	1.1	1.3	3.0	0.7	-1.2	-1.1	1.7	0.5	-1.4	-0.8
Gout (self-reported)	0.3	0.4	1.2	0.1	-0.4	-0.6	0.6	0.7	-0.3	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.0	-1.7	0.1	-0.0	1.1	-1.1	0.2	1.5
Medication: Amlodipine	1.6	2.2	6.7	-2.1	-0.8	-1.3	1.1	-2.6	-0.1	-1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.4	0.6	-0.4	-0.5	0.2	-0.2	0.1
Birth weight	0.2	0.3	0.9	0.6	-0.0	1.0	0.1	0.7	0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.2	-1.0	-0.5	0.3	0.7	-1.5	1.0	0.7
High blood pressure (siblings)	0.8	1.2	3.0	-1.1	0.3	-0.2	-1.2	-0.6	1.7	-1.4
Forced vital capacity (FVC), Best measure	0.7	2.4	11.7	-1.3	1.4	3.4	-0.8	-0.5	-0.9	0.2
Body fat percentage	0.9	3.4	10.1	-3.2	-1.4	-1.4	1.6	-2.7	0.0	-0.3
Leg fat percentage (right)	1.0	3.5	7.9	-2.8	-1.8	-1.9	1.1	-2.8	-1.1	-0.5
Arm fat-free mass (right)	0.3	1.6	3.4	-1.3	1.5	1.2	-0.5	-0.7	1.8	1.2
Exposure to tobacco smoke outside home	0.2	0.2	0.8	-0.2	0.3	-0.2	0.9	-0.7	0.1	0.3
Comparative body size at age 10	1.6	4.4	26.6	0.8	-0.2	0.1	0.5	0.8	-5.2	-1.5
Number of full brothers	0.7	0.8	3.6	-0.9	-1.9	0.2	0.7	-0.3	-0.9	-0.1
Worry too long after embarrassment	0.2	0.4	1.7	0.1	-1.3	-0.1	0.4	-0.4	0.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.3	0.0	-0.6	-0.9	0.4	1.5	0.0	-1.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	-1.1	-0.8	-0.6	0.4	-0.9	1.2	0.5
Number of children fathered	0.7	0.8	2.0	1.4	1.1	0.5	-0.9	1.1	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.7	0.4	1.4	1.9	-0.1	-0.1	2.2	1.6
Age at first live birth	0.6	1.1	2.1	-1.1	-0.1	1.5	-0.9	-0.5	-1.3	1.4
Pulse wave peak to peak time	1.4	1.6	3.0	1.2	-1.2	-1.7	1.3	0.3	1.5	-1.0
Health satisfaction	1.3	1.7	3.4	0.3	-1.4	-1.6	0.3	-1.2	-1.4	-1.8
Shortness of breath walking on level ground	0.9	1.1	2.9	0.3	-1.7	-0.7	1.7	-0.8	0.0	0.9
Qualifications: College or University degree	0.2	0.6	1.9	0.4	0.6	-0.3	-0.6	1.4	-1.2	0.0
Eye problems/disorders: None of the above	1.3	1.5	3.5	-1.7	0.2	-0.7	0.6	-1.3	-1.2	1.9
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.3	0.7	-1.4	-1.0	2.3	-0.1	-2.2	-0.6
Emphysema/chronic bronchitis	1.4	1.6	2.5	1.3	1.2	0.4	-1.6	1.6	1.2	-1.2
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	-0.7	1.1	1.6	-0.6	0.1	-0.1	1.4
Neck or shoulder pain in last month	0.9	1.2	5.5	-1.3	-0.7	-0.4	-0.3	-2.3	-0.8	0.0
Medication: Blood pressure	0.5	0.9	2.8	-0.9	0.5	-0.6	-0.1	-1.4	-0.2	-1.7
Angina (self-reported)	0.8	1.1	4.9	-0.1	-1.0	-2.2	0.4	-1.1	-0.4	-0.2
Migraine (self-reported)	0.8	1.0	3.2	-0.8	-0.1	-1.5	0.2	-1.8	0.4	0.7
Medication: Ibuprofen	0.3	0.3	1.1	1.0	-0.2	-0.5	-0.7	0.4	-0.4	-0.3
Medication: Allopurinol	0.4	0.6	2.9	0.3	-0.4	-0.2	-0.3	0.9	-0.0	-1.7
Medication: Omeprazole	0.8	1.0	2.8	-0.0	-0.0	0.2	1.7	1.1	1.3	1.0
Medication: Seretide 50 evohaler	0.7	0.8	2.6	0.2	-0.2	-1.6	0.8	0.5	-0.2	-1.3
Mean time to correctly identify matches	0.5	0.9	3.2	-0.6	1.4	-0.2	-0.4	0.5	1.8	0.6
Heart disease (mother)	0.3	0.4	1.0	-0.2	1.0	0.3	-0.2	-1.0	-0.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	-0.3	-1.2	-0.3	0.9	0.2	-1.4	0.8
Whole body fat mass	0.6	2.4	8.8	-3.0	-0.5	-0.7	1.0	-2.5	0.5	-0.3
Leg fat mass (right)	0.7	2.8	9.1	-3.0	-0.8	-0.8	0.7	-2.9	-0.2	-0.2
Arm predicted mass (right)	0.3	1.7	3.1	-1.2	1.8	1.4	-0.7	-0.7	1.7	1.1
Pulse rate, automated reading	0.6	1.9	5.6	-2.4	1.1	1.0	-0.8	-1.6	-1.4	0.6
Alcohol intake frequency.	2.0	4.6	13.2	-3.6	-1.2	0.4	1.0	-3.4	-2.1	-0.3
Comparative height size at age 10	1.4	7.5	19.3	1.1	4.2	2.4	-1.3	1.9	4.4	1.9
Number of full sisters	0.5	0.7	2.6	-0.3	-1.0	-1.6	0.3	-0.9	-0.2	0.3
Suffer from ‘nerves’	1.5	2.3	6.6	-1.2	-0.2	-0.9	-0.7	-0.8	-2.6	-2.5
Overall health rating	0.9	1.9	4.3	-1.9	0.6	0.4	-1.5	-2.1	-1.6	-0.3
Chest pain or discomfort	0.8	1.1	3.2	-0.8	-1.2	-1.0	0.0	-0.9	-1.8	0.8
Had major operations	1.1	1.3	4.6	-2.1	-0.2	-0.1	-0.4	-2.1	-0.3	-0.2
Age at last live birth	0.7	1.0	4.2	-0.8	-0.1	0.7	0.1	-1.1	-0.4	2.0
Family relationship satisfaction	0.4	0.5	1.5	1.2	0.2	-0.1	-1.1	0.6	-0.3	-0.1
Leg pain on walking	0.3	0.4	1.0	-0.7	-0.5	0.2	-0.0	-1.0	0.8	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.3	0.7	-1.1	0.4	1.8	0.4	-1.8	-1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	-1.3	-0.2	-0.4	0.1	-1.2	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.2	1.1	0.8	1.1	-0.8	0.9	1.0	0.6
Medication: Aspirin	1.7	2.3	7.6	-1.7	-0.2	-0.8	-0.7	-2.8	1.9	0.6
Supplements: Vitamin C	2.0	2.4	5.6	1.6	-1.7	-2.4	0.5	1.1	1.9	-0.6
Knee pain experienced in last month	0.2	0.4	1.7	-0.5	0.2	0.4	-0.4	-1.3	0.6	0.1
Hypertension (Self-reported)	1.5	4.3	9.4	-1.4	-2.2	-2.6	2.0	-3.1	-0.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	-0.1	-1.9	-1.2	1.3	0.8	0.6	-1.3
Illnesses of father: Heart disease	1.5	2.1	5.0	-1.9	-1.0	1.3	1.2	-2.2	-0.3	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.7	0.3	0.1	-1.3	-0.2	0.1	-1.0
Smoking status: Previous	0.1	0.2	0.4	-0.2	-0.3	0.2	0.6	0.4	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	0.7	0.6	0.8	0.8	1.1	-0.3	-0.3
Whole body fat-free mass	0.3	1.5	4.6	-0.9	1.7	1.0	-0.4	-0.3	2.1	0.7
Leg fat-free mass (right)	0.2	1.1	3.1	-0.9	1.6	1.1	0.3	-0.1	1.8	0.5
Arm fat percentage (left)	0.6	2.5	6.3	-2.5	-1.5	-1.5	1.7	-1.7	0.5	-0.7
Average weekly red wine intake	0.7	1.0	2.6	-0.4	0.9	0.6	-1.5	0.5	-1.6	-0.6
Handedness (chirality/laterality): Left-handed	1.6	2.0	4.3	-1.3	2.1	1.7	-1.2	-1.1	-1.3	0.2
Mood swings	0.8	1.4	3.6	1.9	-0.7	0.0	-0.3	1.2	-1.0	-1.8
Loneliness, isolation	1.3	1.8	7.7	-0.3	1.7	1.3	-2.8	-0.4	0.4	-0.5
Long-standing illness, disability or infirmity	1.6	2.4	5.0	-1.3	-1.9	-1.7	1.3	-2.2	-0.8	-1.0
Ever had bowel cancer screening	0.8	1.0	3.6	-1.2	-0.4	-1.9	0.2	-1.0	0.4	0.5
Diabetes diagnosed by doctor	1.3	2.2	5.9	-2.4	-1.4	-0.8	0.3	-1.6	1.9	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.1	0.8	-0.1	-2.0	1.1	0.4	-1.9	0.0
Friendships satisfaction	0.7	0.8	1.9	0.3	-1.4	-0.9	0.2	-0.7	-1.2	-1.0
Qualifications: nursing, teaching	0.5	0.8	2.4	0.3	1.0	-1.0	-0.3	0.9	0.5	1.5
Commuting to job workplace: Walk	0.7	0.8	3.8	0.5	-0.2	0.6	-0.3	0.6	-0.8	-1.9
Eye problems/disorders: Cataract	0.7	0.8	1.6	0.5	-0.8	1.3	0.3	0.8	0.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-0.5	-0.6	-0.9	0.4	0.1	-1.4	-0.9
Medication for cholesterol	2.2	3.4	11.8	0.7	3.4	1.8	-2.3	1.5	-0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	-1.6	-0.5	-0.4	-0.1	-1.6	1.1	0.8
Back pain experienced in last month	1.1	1.6	5.1	-2.0	-1.0	-0.4	-0.5	-2.3	-1.0	-0.5
Mineral and other dietary supplements	1.2	1.7	4.3	-1.7	-1.1	0.5	2.1	-1.5	-0.6	0.7
Breast cancer (self-reported)	0.3	0.3	1.1	-1.0	0.1	-0.6	0.3	-0.7	0.2	-0.6
Asthma (self-reported)	0.7	1.4	2.6	-0.5	-1.3	-1.6	1.0	-0.6	1.6	1.3
Osteoporosis (self-reported)	0.9	1.1	2.7	-1.1	-1.1	-0.7	0.6	-1.2	0.3	-1.6
Osteoarthritis (self-reported)	0.5	0.7	1.5	-1.0	0.9	-0.3	-1.0	-0.5	0.1	-1.2
Medication: Aspirin	1.7	2.2	7.9	-1.7	-0.2	-0.8	-0.3	-2.8	1.8	0.6
Medication: Gliclazide	0.7	0.8	1.8	-1.3	-1.0	-0.5	0.7	-0.5	1.3	-0.6
Illnesses of father: None of the above (group 1)	1.7	2.1	3.5	1.8	-1.9	-1.9	1.0	1.6	0.6	0.6
Smoking status: Current	0.4	0.6	2.4	0.3	-0.5	-0.9	0.3	-0.5	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.5	-0.5	0.9	1.4	-2.1	-0.3	-1.6	0.3
Whole body water mass	0.3	1.5	4.9	-0.9	1.7	0.9	-0.4	-0.3	2.2	0.8
Leg predicted mass (right)	0.2	1.2	3.2	-0.9	1.6	1.1	0.2	-0.1	1.8	0.5
Arm fat mass (left)	0.4	1.4	4.7	-2.2	-0.5	-0.7	1.1	-1.6	0.9	-0.4
Number of self-reported non-cancer illnesses	2.9	4.9	10.5	-1.9	-2.9	-3.2	2.3	-2.4	0.9	-0.6
Average weekly champagne plus white wine intake	0.8	1.1	4.7	0.6	0.0	-0.5	0.3	1.4	-0.3	-2.2
Miserableness	1.7	2.9	8.0	1.4	-1.8	-1.1	1.2	1.5	-2.8	-1.4
Guilty feelings	0.3	0.5	1.3	0.4	-0.8	0.5	-0.4	-0.4	1.1	0.7
Wears glasses or contact lenses	1.3	1.5	3.2	-0.6	1.2	1.4	-1.2	-0.6	1.3	1.8
Ever taken oral contraceptive pill	0.6	0.6	2.0	-1.4	0.6	0.9	-0.2	-0.2	-1.0	0.1
Hearing aid user	0.2	0.2	0.6	-0.7	-0.1	0.3	0.2	-0.7	0.1	0.2
Mother’s age at death	1.1	1.4	8.8	-0.3	0.1	-0.4	-0.2	-0.6	-0.7	-3.0
Financial situation satisfaction	0.6	0.7	2.5	-0.3	-0.2	-0.2	-0.9	-1.6	-0.6	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	-1.2	-0.8	-0.6	1.5	-0.8	0.2	-0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.6	0.4	0.1	-0.1	0.5	-0.5	-0.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.9	1.3	-0.8	-0.3	0.7	0.9	-0.5	-1.7
Medication: Blood pressure	1.9	3.6	8.0	-0.1	-2.7	-2.8	2.5	-1.4	1.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	-0.5	0.4	0.4	0.2	0.2	1.3	0.3
Supplements: Fish oil (including cod liver oil)	1.6	2.1	6.7	1.3	1.7	0.2	-2.6	1.4	0.9	-0.9
High cholesterol (Self-reported)	0.6	1.2	5.9	-1.4	-0.2	0.3	0.1	-2.4	-0.2	0.1
Medication: Bendroflumethiazide	0.6	0.9	3.5	-0.5	-0.9	-0.5	1.2	-1.9	0.4	0.4
Medication: Paracetamol	0.8	1.2	3.0	1.4	-0.0	0.8	0.8	1.7	-1.3	-0.6
Medication: Lisinopril	1.2	1.6	4.4	-1.3	-0.0	-1.7	-0.4	-2.1	-1.2	-0.9
Medication: Atorvastatin	1.2	1.5	4.2	-1.8	-0.6	-0.6	0.6	-2.0	-1.0	-1.1
Illnesses of father: High blood pressure	0.7	0.9	2.3	0.7	0.0	1.3	-0.5	1.5	1.0	-0.9
Alcohol drinker status: Never	1.0	1.3	4.6	-1.2	0.3	1.0	0.4	-1.2	0.4	2.2
Ever smoked	0.5	0.9	2.3	-0.2	-0.4	-1.0	0.7	0.5	-1.4	-1.5
Basal metabolic rate	0.2	1.4	4.6	-1.2	1.4	0.7	-0.0	-0.6	2.1	0.8
Leg fat percentage (left)	1.0	3.7	5.6	-2.4	-2.2	-2.2	1.9	-2.3	-1.1	-0.9
Arm fat-free mass (left)	0.2	1.1	2.1	-1.0	1.5	1.0	-0.3	-0.8	1.4	0.9
Number of operations (self-reported)	1.0	1.6	3.6	-0.7	-1.0	-1.9	1.8	0.0	1.3	-1.1
Average weekly beer plus cider intake	0.7	0.9	4.3	0.2	0.7	1.1	-2.1	0.6	-0.1	-0.2
Irritability	0.4	0.6	3.2	0.0	-0.1	-0.2	-1.0	-0.2	-0.2	-1.8
Risk taking	0.4	0.6	2.9	-0.5	0.2	-0.7	-0.4	0.6	1.7	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.5	-1.2	-0.0	-0.8	-0.8	-0.3	-0.3	-0.1
Fractured/broken bones in last 5 years	0.9	1.1	3.5	0.3	1.8	0.2	-0.9	-0.1	-1.9	-0.5
Age started oral contraceptive pill	0.4	0.5	2.2	-0.4	-0.6	-0.5	-0.3	-1.5	0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.3	-0.7	-0.2	1.1	1.1	-1.0	1.1	-0.4
Ever depressed for a whole week	0.3	0.3	0.9	-0.8	0.6	-0.4	-1.0	-0.1	0.2	-0.5
Unable to work because of sickness or disability	2.1	2.8	6.5	-2.5	-0.8	-1.3	-0.2	-2.2	-2.1	-1.2
Commuting to job workplace: Cycle	0.4	0.5	1.2	1.0	-0.2	-0.7	1.1	0.6	0.3	0.8
Myopia	0.6	0.8	3.9	-0.3	-0.8	-2.0	0.7	-0.2	0.5	0.5
Vascular/heart problems diagnosed by doctor	1.7	4.8	12.7	1.0	2.3	3.6	-1.9	2.7	0.4	1.8
Cholesterol lowering medication	1.3	1.9	4.9	-1.1	-2.2	-0.7	1.6	-1.9	0.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.5	-0.6	-0.3	-0.0	1.6	0.6	1.6	0.5
Pain experienced in last month	0.4	0.7	3.2	0.3	0.4	0.4	0.9	1.8	0.5	-0.7
Supplements: Calcium	0.5	0.6	1.4	-0.5	-0.8	-0.9	-0.0	0.2	0.9	1.2
Basal cell carcinoma (self-reported)	0.3	0.4	2.0	-1.4	0.3	0.4	0.4	-0.4	0.2	0.1
Heart attack/myocardial infarction (self-reported)	2.7	3.5	9.4	2.1	-1.0	-3.1	0.2	1.7	0.3	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.0	-0.7	0.2	-0.4	0.2	-1.0	0.5	0.3
Heart disease (siblings)	0.7	0.9	3.3	-0.5	-0.1	-1.8	0.2	-0.9	-1.3	0.0
Alcohol drinker status: Previous	0.8	0.9	3.8	-0.7	-0.6	1.2	-0.3	-0.1	-0.4	-2.0
Pack years of smoking	0.2	0.4	1.4	0.4	0.6	-0.2	0.6	0.3	-0.3	1.2
Impedance of whole body	0.1	0.4	1.9	-0.3	-1.4	0.1	0.9	-0.3	-0.1	0.0
Leg fat mass (left)	0.6	2.3	7.2	-2.7	-0.8	-0.9	1.0	-2.5	-0.1	-0.5
Arm predicted mass (left)	0.2	1.2	2.5	-1.4	1.2	0.8	-0.2	-1.1	1.6	0.7