TWAS hub - SGCD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2120	0.0520	1.8e-06	0.002	0.055	0.048	0.062	0.031	1.7e-01	3.0e-07	1.4e-06	4.6e-08	9.8e-05
2	GTEx	Adrenal Gland	0.3561	0.1026	1.2e-04	0.216	NA	0.142	NA	0.264	2.8e-08	NA	8.9e-06	NA	5.3e-10
3	GTEx	Artery Aorta	0.2580	0.0610	5.0e-08	0.087	NA	0.184	NA	0.170	1.6e-05	NA	2.2e-10	NA	1.1e-09
4	GTEx	Artery Tibial	0.1212	0.0439	3.0e-04	0.033	NA	0.035	NA	0.036	1.2e-03	NA	9.7e-04	NA	7.8e-04
5	GTEx	Cells Transformed fibroblasts	0.1930	0.0420	2.6e-08	0.067	NA	0.172	NA	0.183	9.4e-06	NA	7.0e-13	NA	1.1e-13
6	GTEx	Thyroid	0.3630	0.0560	1.2e-12	0.281	NA	0.282	NA	0.277	1.0e-21	NA	8.7e-22	NA	2.2e-21
7	METSIM	Adipose	0.0854	0.0314	9.2e-04	0.025	0.028	0.036	0.038	0.032	8.7e-05	4.2e-05	3.0e-06	1.9e-06	1.2e-05
8	YFS	Blood	0.0277	0.0105	1.4e-03	0.019	0.009	0.014	0.012	0.014	4.1e-07	4.6e-04	1.1e-05	6.9e-05	1.3e-05
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0380	0.0174	5.0e-03	0.008	0.011	0.009	NA	0.015	3.6e-02	1.9e-02	2.8e-02	NA	7.1e-03
10	TCGA	Brain Lower Grade Glioma	0.0659	0.0241	4.8e-05	0.044	0.046	0.038	NA	0.051	8.5e-06	5.0e-06	3.8e-05	NA	1.8e-06
11	TCGA	Lung Adenocarcinoma	0.0522	0.0193	2.7e-04	0.038	0.039	0.009	NA	0.035	2.6e-05	2.1e-05	3.0e-02	NA	5.6e-05
12	TCGA	Thyroid Carcinoma	0.1030	0.0340	2.0e-04	0.099	0.053	0.099	NA	0.098	6.7e-10	6.9e-06	6.8e-10	NA	8.2e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Suffer from ‘nerves’	6.5	10.3	25.6	-1.9	-3.9	-3.5	-4.1	-2.5	0.1	3.1	0.1	-5.1	-4.1	-4.1	0.7
Falls in the last year	4.1	5.5	10.8	-0.3	2.4	2.7	2.6	2.8	1.8	-2.4	-1.1	3.3	3.3	2.7	0.7
Loud music exposure frequency	4.1	4.5	9.5	0.3	2.3	3.1	1.8	3.1	0.8	-2.6	0.3	2.1	2.3	3.0	-0.0
Medication: Omeprazole	4.0	4.7	16.8	0.6	0.4	2.6	4.1	-0.4	0.0	0.3	-1.3	3.4	3.6	2.6	-0.0
Diabetes (father)	3.9	4.8	9.7	-2.1	3.1	1.8	1.6	3.1	-0.8	-2.3	-1.2	3.1	1.5	2.4	-1.7
Pulse wave Arterial Stiffness index	3.4	4.0	9.6	-0.3	-2.1	-2.1	-2.4	-2.8	-1.5	1.0	-0.5	-2.0	-2.5	-3.1	-1.2
Average weekly red wine intake	3.4	5.0	10.7	-2.1	-0.4	-3.3	-2.8	-3.1	-2.5	1.5	-0.2	-2.2	-2.8	-1.8	-1.7
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	9.4	-2.9	-1.2	-1.0	-1.7	0.1	1.0	0.7	-3.1	-2.1	-1.7	-3.0	1.1
Pulse wave peak to peak time	3.0	3.5	8.0	0.4	1.8	2.3	2.4	2.6	1.0	-1.0	0.7	1.9	2.5	2.8	0.7
Current tobacco smoking	2.9	4.8	8.0	-1.4	2.1	2.8	2.7	2.4	2.6	-0.6	0.2	2.5	2.8	1.8	2.3
Wheeze or whistling in the chest in last year	2.9	5.1	11.2	0.6	2.6	3.4	2.5	2.9	2.7	-1.5	-1.5	2.6	2.1	1.7	1.7
Medication: Seretide 50 evohaler	2.9	3.4	6.7	1.7	-2.5	-1.5	-1.6	-1.9	-2.5	1.2	-0.1	-2.6	-1.6	-1.9	-1.6
Fractured/broken bones in last 5 years	2.9	3.8	8.5	-0.6	2.6	2.9	2.4	1.5	-1.0	-0.9	-0.4	1.7	2.6	2.9	-1.3
Coronary Artery Disease (CAD)	2.7	3.2	8.3	0.7	-1.4	-2.2	-2.5	-1.8	0.4	1.3	-1.0	-2.9	-2.8	-1.6	0.5
Qualifications: CSEs or equivalent	2.6	3.5	14.7	-2.2	2.9	1.8	0.1	2.1	0.4	-3.8	0.3	1.6	1.0	1.1	-0.7
Hair/balding pattern: Pattern 2	2.4	3.0	7.1	0.3	2.2	1.4	2.2	0.8	-0.7	-0.7	1.2	2.7	2.6	2.6	-0.9
Mouth/teeth dental problems: Dentures	2.4	4.0	8.2	1.1	-0.1	2.3	2.8	2.9	2.6	-1.2	-0.4	1.4	2.6	1.1	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	10.6	0.8	2.0	1.4	0.6	3.3	3.0	-2.6	-0.2	1.3	0.4	2.2	2.0
Systolic Blood Pressure	2.3	11.4	35.1	-2.5	-2.3	-5.9	-5.4	-1.8	1.0	0.9	-1.8	-3.9	-5.3	-2.4	1.7
Risk taking	2.3	3.4	10.9	1.0	2.6	3.3	2.0	1.6	0.7	0.8	0.1	1.3	1.7	2.9	0.6
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	8.8	0.2	0.0	1.7	3.0	-0.6	0.4	0.2	-0.1	2.9	2.6	2.5	0.3
Schizophrenia (2018)	2.2	4.5	12.5	0.9	2.0	3.5	2.7	2.5	1.6	-1.9	-0.5	1.8	2.7	2.3	0.8
Family relationship satisfaction	2.2	2.7	6.6	1.5	1.2	2.2	1.5	1.0	1.5	-2.6	-0.1	2.1	1.6	1.5	1.4
Shortness of breath walking on level ground	2.1	2.5	5.5	-1.3	0.9	2.3	1.9	2.2	1.7	-2.0	-0.6	0.8	2.2	0.7	0.8
High cholesterol (Self-reported)	2.1	3.8	7.7	-2.0	-2.4	-2.6	-1.8	-2.1	-1.7	0.6	0.6	-2.8	-1.8	-2.4	-1.0
Medication: Atorvastatin	2.1	2.6	5.7	0.5	-0.6	-1.9	-2.0	1.0	2.3	0.1	-1.1	-1.7	-1.8	-1.9	2.4
Worry (Nagel 2018)	2.0	4.2	8.6	-2.0	-1.9	-2.6	-2.8	-2.2	-0.7	1.4	1.1	-2.9	-2.7	-2.0	-0.3
Vitamin and mineral supplements	2.0	2.7	8.9	1.2	2.5	1.3	1.7	1.3	0.8	-1.9	1.1	3.0	1.7	1.4	-0.2
Age at first live birth	2.0	3.5	7.0	0.5	-2.6	-2.4	-1.6	-2.6	-1.7	2.0	2.5	-1.9	-1.7	-0.6	-0.5
Triglycerides	1.9	3.0	8.7	-1.3	-0.1	-1.7	-2.5	1.5	3.0	-0.7	-0.3	-1.9	-1.9	-1.0	2.3
Blood White Count	1.9	14.0	30.2	0.5	3.3	5.5	4.6	5.1	2.7	-3.1	0.5	4.8	4.8	3.2	2.1
Neuroticism	1.9	4.6	10.2	-1.4	-1.9	-1.7	-2.7	-1.9	-1.5	2.2	1.6	-3.1	-3.2	-2.2	-1.2
Chronotype (morning person)	1.9	4.4	11.1	0.8	1.8	1.2	2.6	1.7	-0.5	-2.6	1.2	3.3	2.6	3.0	-1.5
Neuroticism score	1.9	3.9	7.8	-1.0	-2.1	-1.2	-2.4	-2.3	-1.1	2.4	1.2	-2.7	-2.8	-2.3	-0.8
Noisy workplace	1.9	2.4	11.0	0.5	1.2	0.2	1.3	1.6	3.3	-0.1	-0.9	1.5	0.7	-0.6	2.7
Smoking status: Current	1.9	3.1	5.4	-1.8	1.9	2.3	1.9	2.0	2.1	-0.1	0.4	1.6	2.0	1.4	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	13.2	1.1	0.7	-3.1	-3.6	-0.1	0.3	-0.9	1.9	-2.4	-3.6	-0.9	-0.0
Supplements: Calcium	1.9	2.1	11.6	-0.3	-1.1	-1.0	0.8	-2.8	-0.4	3.4	-1.3	-1.1	0.0	-0.1	0.3
Financial difficulties in last 2 years	1.8	2.5	12.4	-1.3	1.0	3.5	2.4	1.2	-0.0	-0.3	-0.0	1.4	1.8	1.4	0.2
Alcohol intake versus 10 years previously	1.8	2.7	11.4	-1.1	1.5	1.6	0.5	3.4	2.6	-1.3	0.2	1.5	0.3	0.5	2.0
Glaucoma (self-reported)	1.8	2.1	7.0	0.2	0.1	-1.4	-2.6	1.1	1.7	-0.9	-2.0	-0.5	-2.1	-1.4	0.8
Major Depression (MDD)	1.7	2.1	6.9	-1.0	1.3	-0.2	0.4	-0.7	2.6	1.4	-1.3	1.6	0.5	1.6	2.4
Age at First Birth	1.7	2.4	7.5	0.1	-1.1	-2.7	-1.7	-2.0	-0.6	0.8	1.0	-2.7	-1.5	-1.4	-0.2
BMI	1.7	9.6	20.8	2.4	4.4	3.5	3.9	2.7	1.9	-2.2	1.0	4.6	3.5	3.6	0.9
Medication: Atenolol	1.7	2.1	8.9	-1.2	1.2	-3.0	-1.9	0.2	1.2	-0.5	0.3	-0.2	-2.5	-0.7	1.2
Nervous feelings	1.7	3.2	9.6	-1.9	-1.1	-2.3	-2.9	-0.9	0.1	1.4	0.2	-2.0	-3.1	-1.8	-0.1
Medication: Gliclazide	1.7	1.9	4.9	2.0	0.9	2.2	1.7	1.2	-0.7	-0.2	-0.1	0.7	1.8	1.8	-0.8
Age started oral contraceptive pill	1.7	2.1	4.7	-2.1	-0.0	-2.1	-1.9	-2.2	-0.8	1.2	-0.1	-1.4	-1.9	-0.6	-0.6
Had menopause	1.6	2.0	9.9	0.1	-0.6	-3.1	-1.8	0.2	0.8	0.1	0.8	-1.7	-1.9	-1.4	1.1
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.2	0.9	-2.3	-1.9	-0.6	-0.4	1.4	1.7	-2.2	-0.6	-0.4	-1.3	1.6
Heart disease (siblings)	1.6	2.0	4.0	-0.5	-0.9	-1.8	-1.7	0.5	1.4	1.3	-0.7	-1.3	-2.0	-2.0	1.5
Bipolar Disorder or Schizophrenia	1.5	3.6	11.5	-0.7	2.7	3.4	2.1	2.2	1.1	-1.1	-1.0	1.4	2.1	2.2	0.5
Multivitamins +/- minerals	1.5	2.0	5.1	-1.1	-2.2	-1.5	-1.4	-1.1	-0.6	1.7	0.2	-2.2	-1.3	-1.3	-0.0
Waist circumference	1.5	5.4	12.2	1.4	3.0	2.9	3.5	1.9	1.5	-2.1	-1.1	3.2	2.9	1.5	0.7
Pain all over the body in last month	1.5	1.6	5.6	-1.3	0.6	1.3	1.8	0.4	0.6	-1.2	-2.4	1.4	1.5	0.1	0.2
Arm fat percentage (right)	1.5	5.7	12.0	1.5	3.4	2.7	3.3	2.4	1.8	-1.9	0.3	3.5	2.9	1.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	6.8	-0.8	0.5	1.4	-0.3	1.8	2.2	-1.6	-2.6	-0.4	-0.1	0.1	1.6
Mean time to correctly identify matches	1.5	2.9	6.4	1.0	-1.7	-2.4	-2.0	-2.2	0.2	2.5	-1.4	-1.9	-1.8	-0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	5.3	0.6	-2.0	-0.7	-0.7	-2.2	-1.6	2.3	2.0	-1.4	-1.0	-1.2	-1.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	7.7	-0.5	0.1	2.8	2.1	2.0	0.2	0.9	-1.1	1.3	1.6	0.2	-0.3
Ever had prostate specific antigen (PSA) test	1.5	1.8	8.9	-0.3	-1.9	0.7	-0.2	-0.2	-3.0	0.4	-0.4	-1.5	-0.3	-0.4	-2.3
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.5	-0.9	2.1	0.2	1.0	1.2	2.0	-0.7	0.2	1.7	1.2	1.4	1.7
Supplements: Zinc	1.4	1.5	3.4	-0.1	-0.6	-1.8	-0.8	-1.5	1.7	0.8	-0.2	-1.6	-1.1	-0.8	1.9
Body mass index (BMI)	1.4	6.2	14.0	1.8	3.4	2.6	3.4	2.2	2.2	-1.9	-0.6	3.7	2.8	1.9	1.3
Illnesses of mother	1.4	1.7	7.1	0.6	-0.6	1.7	2.7	-1.1	-0.6	0.4	0.1	1.3	2.2	0.9	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.3	-1.7	-0.5	-1.3	-1.3	-0.4	-1.5	0.7	-0.0	-1.5	-1.6	-1.8	-1.3
Knee pain experienced in last month	1.4	2.2	4.5	0.6	1.4	1.5	1.7	2.1	1.7	-1.1	-1.3	2.0	1.8	0.1	1.2
Arm fat percentage (left)	1.4	5.8	14.2	1.3	3.8	2.5	3.2	2.3	1.8	-1.8	0.2	3.5	2.8	2.0	0.7
Eye problems/disorders: Cataract	1.4	1.6	4.1	-0.8	1.7	0.8	0.7	-0.4	-1.0	-0.1	2.0	1.5	0.9	1.9	-1.4
Waist Hip Ratio (WHR)	1.3	5.9	11.3	-0.9	3.4	2.9	3.1	1.3	0.3	-3.3	-1.4	2.8	3.0	3.0	0.7
Diabetes (mother)	1.3	1.7	3.7	0.8	1.4	1.7	0.8	1.6	-0.4	-0.7	1.3	1.9	1.4	1.7	-0.6
Severe depression (siblings)	1.3	1.5	3.8	-0.3	1.1	0.6	1.0	0.7	2.0	-1.7	-1.4	0.9	1.1	0.5	1.8
Serious illness, injury or assault to yourself	1.3	1.6	4.0	-2.0	0.6	-1.3	-1.8	0.5	1.2	-1.2	-1.2	-0.5	-1.4	-1.6	0.4
Lung cancer (father)	1.3	1.5	5.4	1.2	-1.5	1.1	1.8	-1.3	0.1	0.6	-2.3	0.3	1.6	-0.4	0.2
Arm fat mass (right)	1.3	5.3	12.0	2.0	2.9	2.9	3.5	2.0	1.5	-1.4	-0.1	3.4	2.8	1.7	0.7
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.4	-0.0	1.0	1.1	1.7	1.4	1.0	-1.6	-0.6	1.5	1.9	1.5	0.5
Neck or shoulder pain in last month	1.3	1.9	6.7	1.4	0.6	0.4	1.7	0.3	2.2	0.1	-0.0	2.6	1.2	0.6	1.9
Heart disease (mother)	1.3	1.6	6.3	-0.5	0.7	-2.0	-0.1	1.3	2.5	-0.7	0.4	-0.1	0.1	0.2	2.5
Pulse rate, automated reading	1.3	4.0	10.3	0.3	1.8	2.1	2.9	1.0	1.2	-2.1	-0.7	3.2	3.1	2.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	6.3	2.5	-0.6	0.1	1.7	-0.8	0.7	0.1	0.8	1.9	1.5	1.0	0.5
Friendships satisfaction	1.3	1.6	6.3	0.7	1.5	0.8	1.2	0.6	1.6	-2.5	0.1	1.8	1.1	0.3	0.7
Medication for cholesterol	1.3	2.0	4.2	2.0	-0.6	2.1	1.6	-1.2	-1.6	0.8	1.1	0.8	1.7	-0.2	-2.0
Financial situation satisfaction	1.3	1.6	6.4	0.9	0.2	2.1	0.3	1.8	0.7	-2.5	1.1	0.5	0.5	1.2	0.4
Eye problems/disorders: Glaucoma	1.3	1.5	5.4	-0.6	-0.2	-0.7	-2.2	1.0	0.7	0.3	-2.3	-0.9	-1.6	-1.5	0.4
Commuting to job workplace: Cycle	1.3	1.5	4.2	1.9	0.8	1.3	0.5	1.4	0.7	-0.4	1.2	1.6	0.9	2.0	0.7
Depressed Affect (Nagel 2018)	1.2	2.4	5.1	-1.0	-1.5	-1.4	-2.0	-1.4	-0.9	1.3	-0.4	-2.2	-2.2	-2.2	-0.6
Neuroticism (Nagel 2018)	1.2	2.8	5.2	-1.2	-1.5	-2.2	-2.2	-2.0	-0.3	1.3	1.6	-2.1	-2.3	-1.5	-0.0
Systolic blood pressure, automated reading	1.2	3.4	10.9	-1.2	-0.7	-3.1	-3.3	0.0	0.5	-0.2	-0.8	-2.3	-3.1	-1.2	0.8
Number of incorrect matches in round	1.2	1.9	9.7	1.1	-1.1	-3.1	-1.5	-1.4	0.8	0.2	1.1	-1.1	-1.4	-1.1	1.0
Illnesses of siblings	1.2	1.7	4.6	0.5	1.2	1.3	1.6	0.2	-1.7	-0.6	-1.3	1.2	1.2	2.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	10.4	0.7	-1.9	-1.7	-3.0	-1.1	-1.5	-0.2	1.2	-3.2	-2.9	-2.4	-1.4
Birth weight of first child	1.2	2.2	4.0	1.6	-1.7	-1.7	-1.3	-1.8	-0.6	2.0	0.7	-1.8	-1.6	-1.7	-0.2
Alcohol intake frequency.	1.2	2.7	7.3	0.9	0.2	2.4	2.4	0.4	1.6	0.9	-1.3	2.1	2.7	0.9	1.3
Age at last live birth	1.2	1.8	4.0	0.3	-1.8	-1.4	-1.2	-2.0	-0.8	1.4	1.1	-1.8	-1.4	-1.2	-0.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	6.2	2.5	-1.3	-0.2	0.9	-1.3	-1.5	1.5	-0.6	0.6	1.0	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.1	-1.0	1.4	1.0	1.2	1.1	1.4	-1.3	-1.2	1.2	1.0	-0.2	1.1
Arm fat mass (left)	1.2	4.9	10.4	1.7	3.1	2.6	3.2	2.0	1.5	-1.6	-0.2	3.2	2.7	1.6	0.5
Wears glasses or contact lenses	1.2	1.4	4.2	-0.1	0.0	-1.9	-1.6	-0.6	-0.5	0.8	-1.5	-2.1	-1.4	-0.8	-0.3
Alcohol drinker status: Previous	1.2	1.4	3.8	1.2	-0.8	1.8	0.5	-0.8	-1.4	1.2	-1.9	0.6	0.7	0.4	-1.6
Crohns Disease (2012)	1.1	1.8	5.5	2.2	0.4	0.2	0.9	2.0	0.9	-2.4	0.7	2.0	0.8	0.7	0.2
Fasting Glucose	1.1	1.3	6.2	1.2	-1.3	0.3	0.8	-1.1	0.5	2.5	-1.3	-0.4	0.5	-1.1	1.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.8	-1.5	-1.6	-0.8	-1.2	-1.2	0.2	1.2	0.3	-1.8	-1.3	-1.9	0.1
Trunk fat percentage	1.1	4.4	10.4	1.5	3.0	2.2	3.1	1.8	1.0	-1.0	0.6	3.2	2.8	1.7	-0.0
Chronic bronchitis/emphysema (father)	1.1	1.3	3.5	0.1	-1.1	-0.2	1.3	-0.8	1.1	1.9	-1.8	1.1	1.2	-0.2	1.3
Had other major operations	1.1	1.3	4.8	0.0	1.5	0.9	1.1	1.1	0.6	-2.2	0.7	1.4	1.2	1.3	0.3
Father’s age at death	1.1	1.4	4.3	1.1	-1.9	-1.8	-0.8	-2.1	-0.5	0.8	1.4	-0.4	-1.1	-0.3	0.2
Medication: Lansoprazole	1.1	1.3	2.8	0.8	-0.3	0.8	1.4	0.5	0.9	-1.3	-0.2	1.6	1.5	1.7	1.2
Medication: Amlodipine	1.1	1.5	8.0	-2.8	1.7	-0.7	-0.4	1.1	1.4	-0.9	-0.7	1.3	0.1	-0.3	0.7
Number of children fathered	1.1	1.2	3.4	1.8	-0.2	0.7	1.8	-0.2	-0.6	1.7	0.3	1.1	1.5	0.4	-0.7
Whole body fat mass	1.1	4.5	10.6	1.8	2.7	2.4	3.3	1.8	1.4	-1.2	0.0	3.1	2.8	1.4	0.5
Had major operations	1.1	1.3	4.1	0.5	0.3	0.9	1.7	-0.6	-1.8	-0.6	0.5	0.6	1.4	1.2	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.6	-0.3	1.1	1.6	1.9	0.5	0.1	-1.6	-0.4	1.5	1.6	0.5	-0.2
Ever had bowel cancer screening	1.1	1.3	3.5	-0.1	-1.1	-1.0	-1.5	0.2	0.2	1.4	1.3	-1.9	-1.8	-0.4	0.6
Ever smoked	1.1	1.9	8.6	-0.3	1.3	2.9	2.1	0.7	0.1	-0.8	1.3	0.9	1.5	1.1	0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.8	1.7	1.2	0.0	1.0	0.3	1.7	-0.5	0.4	1.4	1.1	1.7	1.0
Alzheimer’s Disease (in mother)	1.0	1.1	3.4	-1.4	1.8	-0.8	-0.5	-1.4	-0.1	1.5	1.2	0.4	-0.8	0.6	-0.6
Smoking Status	1.0	2.3	6.9	-1.8	2.2	2.6	1.4	1.8	0.9	-0.6	1.5	0.9	1.2	1.0	1.0
Hypothyroidism (self reported)	1.0	2.2	5.9	-0.9	0.8	2.4	1.9	0.5	-1.4	-0.9	1.8	1.4	1.9	1.4	-1.4
Ever had hysterectomy (womb removed)	1.0	1.1	3.3	-1.8	1.2	0.1	0.1	1.0	1.8	-1.1	-0.7	-0.7	0.3	-0.5	1.4
Townsend deprivation index at recruitment	1.0	1.5	6.5	-0.0	1.4	1.9	0.8	2.5	1.0	-0.1	0.4	1.1	0.6	1.2	0.9
Fed-up feelings	1.0	1.8	3.9	-1.1	-0.8	-1.4	-1.7	-2.0	-0.8	0.7	-0.4	-1.6	-1.9	-1.8	-0.4
Trunk fat mass	1.0	4.3	10.3	2.0	2.5	2.5	3.2	1.8	0.9	-1.1	0.4	3.1	2.8	1.5	-0.0
Number of live births	1.0	1.4	4.2	-0.9	0.5	1.9	2.0	0.7	0.0	-0.0	-1.6	1.1	1.7	0.8	0.2
Asthma	1.0	2.0	13.3	2.0	-0.0	1.6	1.3	0.6	0.0	0.4	-3.7	0.4	1.4	0.3	-0.4
Prospective memory result	1.0	1.2	6.3	0.2	-0.9	-0.2	0.4	-1.2	-0.1	2.5	1.9	-0.6	-0.5	-1.3	0.4
Exposure to tobacco smoke at home	1.0	1.1	3.7	-0.1	1.4	1.8	1.0	0.5	0.1	-0.7	-0.7	1.0	0.9	1.9	-0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	5.2	-0.6	0.7	-0.3	-1.1	-0.5	-0.7	0.9	2.3	-1.3	-1.8	-0.8	-0.9
Body fat percentage	1.0	4.0	10.2	1.3	3.2	1.9	2.9	1.8	1.5	-1.1	0.3	3.0	2.5	1.4	0.5
Number of full brothers	1.0	1.2	3.1	-0.0	0.7	1.8	1.8	-0.0	1.2	0.1	-1.4	1.4	1.4	-0.1	0.9
Worry too long after embarrassment	1.0	1.6	3.3	0.1	-1.6	-0.8	-1.7	-1.8	-0.7	0.9	1.7	-1.8	-1.4	-0.9	-0.2
Health satisfaction	1.0	1.3	9.4	-1.4	0.3	0.8	0.5	0.9	0.8	-3.1	-0.0	0.8	0.9	0.3	0.3
Medication: Ibuprofen	1.0	1.1	3.5	-1.6	1.9	-0.1	0.4	-0.2	-0.9	-0.6	-1.4	1.2	0.1	1.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.1	-0.9	0.2	-0.9	-1.6	-0.7	0.8	-0.6	-2.0	-1.2	-1.5	-0.7	0.8
Leg fat mass (right)	1.0	3.8	8.7	1.4	2.7	2.1	2.9	1.6	1.5	-0.7	-0.2	3.0	2.4	1.6	0.8
Chest pain or discomfort	1.0	1.4	4.3	-0.3	-0.1	2.1	1.6	1.6	0.7	0.2	-1.7	1.1	1.3	-0.2	0.5
Asthma (self-reported)	1.0	2.0	16.1	1.8	0.0	1.3	1.0	0.9	-0.0	0.4	-4.0	0.3	1.0	0.2	-0.5
Miserableness	1.0	1.8	5.4	-0.3	-2.1	-0.4	-0.1	-2.3	-1.6	2.1	0.2	-1.3	-0.4	-1.2	-1.1
Mother’s age at death	1.0	1.2	3.6	-1.4	0.6	-1.3	-1.5	-0.1	-0.7	-0.3	1.9	-1.1	-1.6	-0.4	-0.5
Medication: Blood pressure	1.0	1.9	3.7	-1.9	0.9	-1.8	-1.8	0.9	1.7	-0.8	0.1	-1.3	-1.4	-0.1	1.9
Unable to work because of sickness or disability	1.0	1.3	6.8	-2.3	-0.5	0.8	1.0	0.3	0.2	0.1	-2.6	0.5	0.9	-0.9	0.1
Leg fat mass (left)	1.0	4.1	9.3	1.6	2.8	2.2	3.0	1.8	1.6	-0.9	-0.4	3.0	2.5	1.4	0.9
Reaction Time	0.9	1.8	6.2	0.9	-0.9	-1.8	-1.1	-2.3	-0.2	2.5	-1.5	-1.0	-0.9	0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.2	0.0	-1.8	-2.3	-1.4	-1.9	-1.5	0.9	1.0	-2.1	-1.1	-1.3	-1.4
LDL Cholesterol	0.9	1.5	3.5	0.2	0.3	-0.3	-1.3	0.6	1.7	1.9	1.3	-1.6	-1.1	-0.8	1.7
Blood Platelet Count	0.9	10.2	32.1	1.5	1.3	5.7	4.6	2.6	1.2	-2.8	-0.4	4.1	5.0	2.6	0.5
Relative age voice broke	0.9	1.4	3.8	0.6	-1.1	-1.9	-0.9	-1.6	0.6	1.8	0.2	-1.0	-1.5	-0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	4.3	-1.1	-1.3	-0.1	-0.6	-0.2	1.7	0.2	-1.3	-1.3	-0.6	-2.1	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	6.6	1.4	-1.4	-1.5	-2.6	-1.5	-1.5	-0.4	1.2	-2.5	-2.4	-1.6	-1.5
Happiness	0.9	1.1	3.4	1.8	-0.7	1.0	1.0	-0.2	0.9	-1.8	0.5	1.1	1.0	0.1	0.8
Forced vital capacity (FVC), Best measure	0.9	3.3	8.8	1.4	-2.2	-0.7	-2.0	-1.1	-2.0	0.5	1.2	-3.0	-1.9	-2.2	-2.0
Migraine (self-reported)	0.9	1.1	2.6	-1.0	-0.2	-0.4	-1.6	-0.2	-1.1	-0.4	-1.4	-0.9	-1.6	-1.2	-1.2
Number of full sisters	0.9	1.1	4.0	1.0	-1.2	0.2	0.5	-1.3	1.8	0.9	-0.2	-0.8	-0.0	-0.2	2.0
Illnesses of father: High blood pressure	0.9	1.1	5.4	-0.0	1.3	0.1	-0.2	-1.0	-1.2	-0.0	0.4	1.5	-0.2	1.0	-2.3
Irritability	0.9	1.6	4.7	0.4	-1.5	-1.3	-0.2	-2.2	0.4	2.2	2.0	-1.0	-0.5	-0.4	0.5
Ulcerative Colitis	0.8	1.1	3.0	1.7	-0.5	0.1	1.6	-1.4	0.6	-0.9	-0.6	0.9	1.6	0.9	0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.3	0.3	1.5	1.5	1.5	1.5	-0.3	-1.1	0.6	1.5	1.4	1.2	-0.9
Lung FEV1/FVC ratio	0.8	4.2	9.5	-1.4	0.8	-3.1	-2.8	0.9	2.4	-2.2	1.3	-1.5	-2.9	-0.7	2.5
Relative age of first facial hair	0.8	1.5	5.7	-1.0	-0.7	-2.4	-1.7	-2.1	0.3	0.2	0.7	-0.7	-1.5	-1.0	-0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-0.1	0.7	0.5	1.5	0.8	0.4	1.0	-0.0	1.6	1.2	1.3	0.6
Angina	0.8	1.0	3.4	-1.8	0.7	-0.5	-0.8	0.8	1.1	0.6	-1.1	-0.8	-1.3	-0.8	1.2
Medication: Metformin	0.8	1.1	2.7	0.0	1.6	0.9	1.0	1.4	-0.5	0.1	-0.9	1.2	1.6	0.7	-0.7
Pack years adult smoking proportion	0.8	1.3	3.7	-1.2	0.2	1.1	0.9	1.9	1.7	-0.1	0.6	0.6	0.7	-1.2	1.5
Impedance of leg (right)	0.8	4.0	8.5	-1.2	-1.4	-2.5	-2.1	-2.9	-1.6	2.7	1.4	-2.7	-2.1	-0.7	-1.1
Leg fat-free mass (left)	0.8	4.1	11.8	1.8	1.6	3.4	2.9	1.7	0.4	-1.8	-0.2	2.9	2.5	1.3	-0.5
High blood pressure (mother)	0.8	1.1	3.1	-1.7	0.7	-0.3	-1.8	0.2	-1.1	-0.5	1.2	-0.3	-1.5	0.2	-1.2
Impedance of leg (left)	0.8	3.9	8.4	-0.8	-1.6	-2.6	-2.1	-2.7	-1.8	2.2	0.9	-2.9	-2.1	-1.3	-1.2
Alcohol usually taken with meals	0.8	1.3	5.0	1.6	-0.1	-0.8	-0.9	-0.9	-2.2	-0.8	0.6	-0.4	-0.7	-0.1	-2.1
Qualifications: None of the above	0.8	1.8	4.4	-1.1	0.3	-0.1	1.3	0.8	1.9	1.8	-2.1	1.7	1.1	-0.2	1.6
Medication: Simvastatin	0.8	1.1	5.2	-2.3	-0.7	-1.4	-1.0	-0.6	-1.3	-0.5	0.2	-0.8	-0.7	-0.6	-1.0
Medication: Cholesterol lowering	0.8	1.2	4.2	-1.6	-1.0	-2.0	-1.1	-1.2	-0.6	0.2	-0.3	-1.0	-0.8	-1.3	-0.2
Depression (self-reported)	0.8	0.9	3.9	1.0	-1.0	0.3	-0.1	0.8	2.0	-0.5	0.4	-0.7	0.0	-1.2	1.5
Leg fat percentage (right)	0.8	3.0	8.8	0.7	3.0	1.1	2.2	1.4	2.2	-0.4	-0.1	2.5	1.8	1.2	1.6
Exposure to tobacco smoke outside home	0.8	1.0	2.5	0.6	-1.0	1.6	0.7	1.3	1.6	0.6	-1.1	0.8	0.4	-0.2	1.2
Qualifications: College or University degree	0.8	2.4	11.7	0.5	-1.3	0.0	-0.4	-1.8	-3.4	1.5	1.3	-1.2	-0.5	0.9	-2.4
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.6	-1.6	-1.9	-0.3	-0.7	-0.4	-0.7	-0.3	-0.4	-1.3	-0.8	-1.1	0.2
Angina (self-reported)	0.8	1.1	2.9	-1.7	0.6	-0.7	-1.1	0.8	1.1	0.6	-0.9	-0.9	-1.5	-0.9	1.0
Leg pain on walking	0.8	1.0	3.5	-1.9	-0.1	1.0	-0.1	1.8	0.1	-0.4	-1.8	-0.4	0.1	-0.3	-0.5
Hypertension (Self-reported)	0.8	2.1	6.5	-1.0	1.0	-2.5	-2.1	0.6	1.8	-1.1	-1.0	-0.7	-1.9	-0.6	1.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.7	0.5	-1.6	-1.0	-1.1	-0.7	-0.7	0.7	0.6	-1.4	-1.2	-0.8	-0.5
Commuting to job workplace: Walk	0.8	0.9	5.8	2.4	-1.0	-0.2	-0.4	0.7	-0.2	-0.9	0.6	-0.2	-0.3	-1.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	5.4	0.5	-0.4	-0.4	0.6	1.0	1.2	-0.1	-2.3	1.1	0.7	-0.4	0.9
Medication: Lisinopril	0.8	1.0	3.3	-1.0	0.6	-1.5	-0.8	0.5	0.9	-1.1	-1.8	0.9	-0.3	-0.7	0.8
Leg fat percentage (left)	0.8	3.1	8.1	0.9	2.8	1.1	2.3	1.6	2.2	-0.8	-0.4	2.5	1.9	0.8	1.6
Average weekly beer plus cider intake	0.8	1.2	4.2	0.3	0.6	1.4	1.3	0.4	0.8	0.3	2.1	1.3	1.1	1.3	1.0
Pack years of smoking	0.8	1.2	3.3	-1.2	-0.3	0.5	0.6	1.7	1.8	-0.0	0.4	0.2	0.5	-1.8	1.8
Ulcerative Colitis (UC)	0.7	1.4	3.2	1.4	-1.3	1.4	1.4	-1.3	-1.2	0.1	-1.8	0.2	1.1	0.1	-0.9
Ovarian Cancer	0.7	0.9	2.7	1.2	-1.0	1.4	1.2	-0.4	-0.6	1.7	-0.9	0.6	0.7	0.5	-0.4
Schizophrenia (2014)	0.7	1.5	4.9	-0.5	2.0	2.2	0.9	1.7	1.0	-1.1	-0.2	0.7	0.9	1.2	0.1
Average weekly spirits intake	0.7	0.9	4.0	-1.0	0.8	-1.5	0.0	0.9	-0.2	-0.3	-2.0	1.2	-0.3	0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.6	-0.3	-0.6	0.3	0.9	0.3	1.1	-1.9	-1.6	0.7	0.9	-0.9	0.7
Leg predicted mass (left)	0.7	3.9	11.0	1.8	1.5	3.3	2.9	1.6	0.4	-1.8	-0.2	2.9	2.5	1.2	-0.4
Hearing difficulty/problems with background noise	0.7	1.1	1.8	1.0	1.2	1.0	0.7	1.4	1.3	-1.3	-0.2	1.1	0.9	1.2	0.8
Forced vital capacity (FVC)	0.7	2.9	5.8	1.6	-2.0	-0.7	-1.7	-1.4	-2.3	0.6	0.9	-2.4	-1.5	-1.7	-2.3
Weight	0.7	3.3	8.2	2.3	1.8	2.6	2.9	1.3	0.9	-1.2	-0.2	2.7	2.2	0.7	0.0
Worrier / anxious feelings	0.7	1.4	6.3	-2.5	1.1	-0.6	-0.9	-0.9	-1.2	-0.4	1.2	0.3	-1.2	0.2	-1.5
Pulse rate	0.7	1.2	2.8	-0.4	0.1	1.0	1.5	1.6	0.9	-1.1	-0.0	1.4	1.7	1.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.5	0.5	-1.1	-1.3	-1.3	0.5	-0.2	1.2	0.4	-1.4	0.3	0.5
Length of working week for main job	0.7	0.7	2.9	-0.3	0.7	0.4	1.1	0.4	0.6	-0.8	-1.3	0.5	0.7	1.7	0.5
Headache pain in last month	0.7	1.2	3.0	0.6	-0.9	-1.7	-1.4	-1.3	0.3	0.5	0.3	-1.2	-1.4	-1.7	0.2
Comparative body size at age 10	0.7	1.9	6.9	-0.8	1.3	2.6	2.3	1.3	0.4	-0.3	1.1	0.6	1.9	1.1	0.1
Medication: Aspirin	0.7	0.9	4.7	-2.2	-0.7	-1.2	-0.7	-0.2	-0.5	-0.4	-0.3	-1.4	-1.1	-0.6	-0.4
Leg fat-free mass (right)	0.7	3.6	10.0	2.0	1.2	3.2	2.6	1.6	0.3	-2.1	-0.5	2.7	2.3	0.7	-0.6
Loneliness, isolation	0.7	1.0	3.4	-0.6	-0.1	0.1	-1.9	1.0	0.8	-0.3	0.1	-0.5	-1.8	-1.6	0.5
Diabetes diagnosed by doctor	0.7	1.2	2.3	0.1	1.5	1.3	1.5	1.4	-0.3	-0.3	-0.2	1.2	1.3	1.2	-0.7
Qualifications: nursing, teaching	0.7	1.0	2.5	1.6	-0.5	-0.9	-0.2	-1.5	-1.5	-1.3	0.5	0.3	-0.2	-0.1	-1.5
Mineral and other dietary supplements	0.7	0.9	3.4	-0.4	1.9	1.5	0.0	0.4	-0.5	-1.4	1.0	0.5	-0.1	1.0	-0.7
Leg predicted mass (right)	0.7	3.5	9.5	2.1	1.2	3.1	2.6	1.6	0.3	-2.1	-0.5	2.6	2.2	0.7	-0.5
Hearing aid user	0.7	0.8	1.9	0.8	-0.9	-0.7	0.6	-1.0	-1.4	0.6	1.2	0.1	0.1	-1.0	-1.2
Commuting to job workplace: Public transport	0.7	0.8	2.4	0.9	0.3	-1.0	0.3	-0.1	1.6	-0.7	1.4	0.7	0.7	-0.5	1.3
Medication: Bendroflumethiazide	0.7	1.1	3.9	-1.7	0.4	-2.0	-1.1	0.3	0.9	-0.8	-0.4	-0.9	-0.8	-0.3	1.3
Myopia	0.7	1.0	4.4	1.4	0.9	-0.7	-0.5	-2.1	1.3	0.2	0.6	-0.1	-0.5	-0.0	1.4
Basal cell carcinoma (self-reported)	0.7	0.8	2.5	-1.3	1.3	-0.6	-1.6	0.4	-0.3	-0.9	-0.2	-0.1	-1.2	-0.4	-0.9
Impedance of whole body	0.7	3.7	7.0	-1.2	-1.4	-2.0	-1.9	-2.6	-2.5	2.0	1.3	-2.5	-1.6	-1.1	-2.2
Bipolar Disorder (2018)	0.6	1.0	5.2	-2.3	1.7	1.1	0.0	0.5	-0.2	0.7	-0.9	0.0	-0.0	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.7	0.7	-1.7	-1.7	-1.5	-1.2	-1.1	0.2	1.7	-2.2	-1.4	-1.5	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-1.2	0.8	-1.0	-0.9	-1.1	-0.5	1.4	1.2	0.5	-1.3	0.5	-0.6
Bipolar Disorder (2011)	0.6	0.6	2.0	-1.0	-0.8	0.5	0.8	0.9	1.0	-0.2	-0.1	-0.2	0.7	-0.8	1.4
Lupus	0.6	1.0	4.8	-0.6	-0.1	-0.4	0.5	-1.6	-1.7	0.6	0.2	0.3	0.2	-0.4	-2.2
Rheumatoid Arthritis	0.6	0.8	2.2	-0.1	0.4	1.5	1.5	1.2	-0.2	-0.3	-0.9	0.6	1.0	0.8	-0.3
Respiratory disease	0.6	1.2	6.2	2.3	-1.0	-0.1	0.8	-0.0	0.1	0.9	-2.5	0.1	0.6	-0.5	0.1
Sensitivity / hurt feelings	0.6	1.1	7.2	-0.7	0.9	0.9	0.4	0.1	-0.1	0.6	2.7	0.6	0.1	1.6	-0.2
Hearing difficulty/problems: Yes	0.6	1.0	3.9	0.7	1.1	0.0	0.6	2.0	1.2	-0.5	1.5	0.5	0.1	0.5	1.1
Average weekly fortified wine intake	0.6	0.7	1.7	1.2	1.1	-1.2	-0.7	-0.7	-0.5	0.4	-0.2	-0.1	-1.3	-0.9	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.3	-1.5	-1.0	1.4	0.9	-0.1	-0.1	0.7	-0.8	-0.0	0.3	-1.1	-0.4
Stomach or abdominal pain in last month	0.6	0.8	4.8	2.2	0.3	0.7	0.2	0.0	1.1	0.1	-0.8	0.4	0.3	0.6	1.1
Medication: Levothyroxine sodium	0.6	1.0	3.1	-1.3	1.4	0.5	1.2	-0.2	-0.9	0.1	0.6	1.8	1.1	0.6	-0.8
Medication: Ramipril	0.6	0.7	2.1	0.3	0.3	-1.3	-0.9	-0.6	1.2	1.0	0.5	-0.5	-0.6	0.6	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	5.8	-0.8	0.5	0.9	0.1	0.6	1.6	-0.4	-2.4	0.5	0.2	-0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.8	1.5	-2.0	-1.3	-0.4	-2.2	-1.1	0.9	1.2	-0.8	-0.2	-0.2	-0.2
Breastfed as a baby	0.6	0.8	2.6	0.5	-1.1	0.2	0.5	0.0	-1.6	0.2	-1.2	0.4	0.8	1.4	-1.0
Tense / ‘highly strung’	0.6	0.9	2.2	-1.1	-1.1	-0.9	-0.9	-1.5	-0.2	1.3	-0.2	-0.9	-1.1	-0.9	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	4.2	1.7	0.4	2.1	1.0	1.0	0.5	0.7	-0.1	0.1	0.7	0.6	0.3
Eye problems/disorders: None of the above	0.6	0.7	3.2	-0.8	-0.6	-0.7	-0.7	-0.2	0.1	0.1	0.1	-1.8	-0.7	-1.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.1	0.5	-1.4	0.4	-0.2	-1.8	-1.7	1.1	0.8	-0.7	0.0	-0.8	-1.5
Back pain experienced in last month	0.6	0.9	2.6	-1.5	-0.1	-1.0	-1.0	0.1	0.3	1.4	-0.7	-0.7	-1.6	-0.9	0.5
Osteoarthritis (self-reported)	0.6	0.7	3.3	-0.8	-0.4	1.1	0.9	0.2	-0.9	0.4	-0.1	1.8	0.6	-0.1	-1.2
Medication: Paracetamol	0.6	0.9	2.9	-1.5	0.7	0.5	0.8	-0.5	-0.7	0.5	-1.7	1.0	0.4	0.5	-1.3
Alcohol drinker status: Never	0.6	0.8	4.5	-0.3	-0.1	-0.1	-0.2	-0.2	-0.4	1.4	-2.1	-0.6	0.1	-1.3	-0.2
Pain experienced in last month	0.6	1.0	4.8	-0.7	0.1	0.3	-0.5	-0.4	-2.2	-0.1	0.9	-0.7	-0.3	0.7	-2.0
Depression (Nagel 2018)	0.5	0.7	3.6	-1.9	-0.8	0.8	0.1	-0.4	0.0	0.3	-0.6	-1.0	-0.0	-1.4	-0.0
Mean Putamen Volume	0.5	0.6	1.7	-0.2	-1.0	0.4	-0.0	-0.8	-1.3	0.5	-0.4	-0.8	0.6	-0.8	-1.0
HbA1C	0.5	0.6	3.4	1.3	-0.6	-0.3	0.6	-1.8	-0.2	0.7	0.0	-0.1	0.3	0.6	-0.2
Allergy or Eczema	0.5	1.3	3.7	1.2	-0.4	-1.9	-1.0	-0.1	-1.9	-0.7	0.7	-0.4	-1.0	0.2	-1.9
Cardiovascular Disease	0.5	1.6	6.0	-1.2	-0.0	-2.5	-2.1	0.4	0.1	-0.7	0.1	-1.5	-1.9	-1.1	0.2
Lung FVC	0.5	2.6	8.7	-0.6	-0.3	-1.5	-2.4	-0.7	-2.5	0.3	0.4	-1.8	-2.0	-0.6	-2.9
Number of treatments/medications taken	0.5	0.9	5.4	-0.4	0.7	-1.3	-0.3	-0.5	0.3	-1.2	-2.3	0.8	-0.2	0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.7	1.2	0.5	0.2	-0.3	-1.0	-1.5	-0.2	1.9	0.4	-0.5	1.4	-1.8
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.3	1.2	-0.1	-1.5	-0.8	0.5	-1.6	-1.4	0.8	-0.0	-0.9	0.5	-1.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.6	-1.0	0.8	0.5	-0.8	-0.9	1.0	0.1	0.7	0.5	0.5	-1.3
Past tobacco smoking	0.5	0.9	3.0	-0.2	-1.0	-1.7	-0.9	-0.4	-0.4	1.3	-1.7	0.2	-0.3	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.7	1.5	-0.3	-0.4	-0.5	-1.9	-1.6	0.2	1.2	0.1	-0.3	0.5	-1.8
Mouth/teeth dental problems	0.5	0.7	3.9	-0.5	1.3	-0.2	-0.2	-0.4	-0.5	-0.8	-2.0	0.7	0.3	0.8	-0.8
Pulse wave reflection index	0.5	0.6	2.6	-0.5	0.5	-0.1	-0.2	-1.6	-1.4	0.3	-0.1	0.4	-0.6	-0.1	-1.4
Gout (self-reported)	0.5	0.7	3.3	-0.9	0.5	-0.0	0.6	-0.3	1.3	0.3	-1.0	0.3	0.9	0.0	1.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.6	-0.9	0.7	1.1	1.0	-0.0	-1.2	-0.0	1.9	1.0	1.0	0.4	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.3	-0.4	-1.2	-0.8	0.4	-1.0	-0.3	1.5	-0.5	-0.3	0.5	-0.4	-0.3
Overall health rating	0.5	1.1	4.2	-2.1	-0.3	0.4	0.1	0.4	1.2	-0.8	-1.8	-0.2	-0.5	-1.4	1.0
Supplements: Vitamin C	0.5	0.6	1.9	0.3	-0.6	0.3	1.4	-1.1	0.0	0.3	-1.0	-0.2	1.1	0.5	0.8
Illnesses of father: Heart disease	0.5	0.7	4.0	0.0	0.0	-0.1	-0.6	2.0	1.5	-0.2	0.2	-0.6	-0.7	0.1	0.9
Breast cancer (self-reported)	0.5	0.5	3.1	-1.2	-0.3	-0.2	-0.2	-0.5	0.3	1.0	1.7	-0.4	-0.3	-0.7	0.2
Medication: Aspirin	0.5	0.7	3.4	-1.8	-0.9	-1.0	-0.1	-0.3	-0.6	-0.2	-0.8	-1.0	-0.7	-0.5	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.7	2.3	-0.7	-0.7	1.0	-0.3	-0.6	-1.4	-0.3	-0.1	-1.5	0.0	-0.7	-0.9
Guilty feelings	0.5	0.7	4.0	0.4	1.2	0.9	-0.4	0.2	0.2	-1.2	2.0	0.2	0.0	-0.0	-0.6
Basal metabolic rate	0.5	2.5	7.2	2.3	0.6	2.7	2.4	1.1	0.5	-1.4	-0.5	2.0	1.9	0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	5.2	1.2	-0.2	2.3	1.4	-0.1	-1.3	0.4	0.8	1.0	1.4	1.0	-1.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.5	1.6	-1.0	1.2	1.2	-0.4	-0.8	-0.6	-1.4	0.7	0.8	-0.5	-0.8
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	0.5	0.4	0.6	0.6	1.0	1.3	-0.5	0.6	-0.2	0.4	-0.1	1.5
HDL Cholesterol	0.4	0.7	3.2	-1.5	-0.4	-0.1	-0.2	0.1	-1.8	0.3	0.4	0.2	-0.4	-0.6	-1.4
Medication for hormone replacement therapy	0.4	0.5	1.5	-0.5	0.0	0.4	0.6	0.3	-1.0	-0.6	-1.2	0.8	0.6	0.5	-0.6
Maternal smoking around birth	0.4	0.6	3.8	0.2	-0.7	-0.0	0.2	0.8	0.7	-1.9	0.1	0.5	0.7	-0.9	0.2
Taking other prescription medications	0.4	0.7	2.2	1.4	-0.2	-0.3	0.8	-0.2	0.0	-0.3	-1.1	1.5	1.1	0.5	-0.1
Age when periods started (menarche)	0.4	0.9	2.9	1.4	-1.0	0.8	1.5	0.8	-0.3	0.1	-1.1	0.4	1.7	-0.5	-0.4
High blood pressure	0.4	1.2	4.3	-0.9	0.7	-2.1	-1.4	0.4	1.3	-0.8	-0.6	-0.5	-1.4	-0.8	1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.3	0.1	0.5	-0.3	-0.0	0.7	-1.2	-0.4	1.5	0.9	0.1	0.2	-0.9
Fluid intelligence score	0.4	0.9	2.7	0.5	-1.2	-0.7	-0.4	-1.0	-1.6	0.3	-0.5	-1.1	-0.3	-0.5	-1.5
Hip circumference	0.4	1.8	4.8	1.6	1.9	1.3	1.9	1.0	1.0	-1.1	-0.3	2.2	1.4	0.2	0.1
Time employed in main current job	0.4	0.4	1.2	0.2	-0.7	-0.1	-1.1	-0.5	-0.9	0.6	-0.8	-0.8	-0.6	-0.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-1.3	1.3	-0.5	-0.3	-0.1	-0.3	0.3	-0.7	0.7	-0.6	0.6	-0.9
Impedance of arm (left)	0.4	2.0	6.2	-1.1	-0.3	-0.9	-1.1	-1.6	-2.3	1.0	1.8	-1.2	-0.6	-0.2	-2.5
Standing height	0.4	3.7	12.1	1.9	-3.5	0.0	-0.7	-2.0	-2.5	1.4	1.0	-2.0	-1.1	-2.3	-2.3
Peak expiratory flow (PEF)	0.4	0.9	2.8	0.9	-0.0	-0.6	-1.0	-1.4	-1.1	-1.7	0.5	-0.8	-1.1	0.3	-0.9
Medication: Paracetamol	0.4	0.7	1.6	-1.1	1.3	0.6	0.3	-0.5	-0.5	0.6	-1.3	1.0	0.1	0.4	-1.0
Medication: Allopurinol	0.4	0.5	1.7	0.3	0.4	-0.8	-0.5	-0.4	1.0	-0.3	-1.0	-0.3	-0.1	-0.7	1.3
Illnesses of siblings: Diabetes	0.4	0.5	1.8	-0.8	0.5	0.5	0.8	-0.5	-0.0	0.2	-1.4	0.3	1.2	-0.5	0.1
Smoking status: Previous	0.4	0.6	2.5	0.9	-0.2	0.1	-0.3	-0.7	-0.4	-0.8	1.6	-1.1	-1.0	-0.6	0.3
Whole body fat-free mass	0.4	2.0	6.5	2.3	0.1	2.5	2.2	0.8	0.3	-1.2	-0.5	1.7	1.6	0.3	-0.1
Mood swings	0.4	0.7	2.8	-0.5	-0.9	-0.3	-0.3	-1.0	-0.1	1.7	-0.6	-0.7	-1.1	-0.6	-0.5
Osteoporosis (self-reported)	0.4	0.5	1.5	1.2	0.5	0.7	0.7	-0.2	-1.0	0.1	0.6	0.2	0.6	0.4	-1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.9	-1.0	0.3	-1.4	-0.5	-0.4	1.0	-0.5	1.0	-0.7	-0.2	0.4	0.9
Ever taken oral contraceptive pill	0.4	0.4	1.5	1.2	-0.0	-0.2	-0.7	0.4	-0.2	-1.1	1.1	-0.0	-0.6	0.4	-0.4
Number of operations (self-reported)	0.4	0.6	2.3	-0.2	0.4	0.6	0.9	-0.4	-0.6	-1.5	0.7	0.6	1.2	0.5	-1.0
Ever depressed for a whole week	0.4	0.5	2.0	0.5	0.8	-0.1	-0.0	-0.3	1.4	-0.9	-0.1	0.1	0.1	0.9	1.1
Cholesterol lowering medication	0.4	0.7	2.1	-1.5	0.1	-1.0	-0.6	1.5	0.3	-0.4	0.1	-0.9	-1.0	0.3	0.5
Crohns Disease (2017)	0.3	0.7	1.4	1.2	-0.7	0.6	0.8	1.0	0.4	-0.9	-1.2	0.8	0.5	-0.7	0.3
Prostate Cancer	0.3	0.4	1.9	1.4	-1.3	0.6	0.1	0.6	0.0	-0.4	-0.1	-0.2	0.6	-0.2	-0.0
Neuroticism (2016)	0.3	0.5	2.2	-0.2	0.2	-0.5	-0.6	-0.8	-0.0	1.1	1.5	-0.0	-0.7	0.5	0.0
Primary Biliary Cirrhosis	0.3	0.4	1.7	-1.3	-0.3	-0.2	0.3	-0.1	-0.8	-0.3	-0.3	-0.2	0.1	-1.1	-0.8
Medication: Co-codamol	0.3	0.4	1.7	0.7	0.8	1.3	-0.1	0.8	0.5	-0.5	-0.7	-0.1	-0.3	-0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	-0.6	0.1	0.0	-1.1	0.4	0.0	-0.3	0.7	0.1	-1.1	-0.5	-0.4
Supplements: Glucosamine	0.3	0.4	2.2	0.9	-0.1	-0.2	0.9	-0.1	-0.3	-0.8	-0.2	0.6	0.7	1.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.0	0.4	0.4	0.9	-0.0	0.3	0.9	-1.4	0.8	0.4	-0.2	0.2	0.1
Allergy	0.3	0.6	2.7	-1.6	0.6	0.7	0.3	-0.3	0.8	0.9	0.5	0.2	0.5	-0.2	1.2
Impedance of arm (right)	0.3	1.6	5.6	-0.5	-0.6	-0.3	-0.7	-1.2	-2.3	0.7	2.0	-1.0	-0.2	-0.1	-2.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	1.0	0.3	0.9	-0.7	1.1	0.5	-0.1	-0.7	-0.5	-0.9	-0.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	1.1	0.4	-0.4	0.4	-0.7	-0.1	-0.8	1.2	0.1	-0.0	1.2	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	3.0	1.7	0.2	-0.4	-0.8	-0.5	0.1	0.4	0.1	-0.0	-0.7	0.2	-0.2
Birth weight	0.3	0.6	1.6	-1.1	-1.0	-1.1	-1.0	-0.1	-0.2	0.4	0.1	-0.1	-0.8	-1.3	0.3
High blood pressure (siblings)	0.3	0.5	1.2	-0.2	-0.9	0.4	-0.4	-0.3	1.1	-0.0	1.0	-0.4	0.3	-0.9	0.9
Medication: Blood pressure	0.3	0.6	2.9	-0.9	0.1	-1.7	-0.5	-0.8	0.2	-1.0	-0.6	0.9	-0.5	-0.1	0.1
Comparative height size at age 10	0.3	1.5	5.7	0.5	-2.1	-0.6	-0.5	-1.2	-0.2	0.7	-0.1	-2.0	-0.8	-2.4	-0.4
Long-standing illness, disability or infirmity	0.3	0.5	1.9	-1.4	-0.9	-0.3	0.1	-0.1	0.3	-0.6	-1.1	-0.6	-0.1	-1.0	0.2
Whole body water mass	0.3	1.9	5.9	2.3	0.0	2.4	2.0	0.9	0.4	-1.3	-0.6	1.6	1.5	0.2	0.0
Number of self-reported non-cancer illnesses	0.3	0.5	2.8	0.1	0.9	-0.0	0.0	-0.1	-0.1	-1.1	-1.7	0.6	0.2	-0.5	-0.2
Arm fat-free mass (left)	0.3	1.8	5.7	2.4	-0.0	1.9	1.9	0.8	0.8	-0.9	-1.3	1.5	1.3	-0.0	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.1	-0.5	0.4	0.9	-0.6	-0.9	0.4	0.4	0.4	0.4	-0.6	-0.7
Arm predicted mass (left)	0.3	1.5	4.4	2.1	0.1	2.0	1.8	0.8	0.6	-0.9	-1.3	1.3	1.2	-0.1	0.3
Alzheimer’s Disease (in father)	0.2	0.3	1.1	0.2	-0.2	0.5	0.4	0.8	-0.4	-0.3	-0.3	1.0	0.1	0.5	-0.5
Breast Cancer	0.2	0.4	1.4	1.0	-0.8	0.8	0.1	0.2	-0.2	0.3	0.5	-1.2	0.2	0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.6	0.6	0.5	-0.1	0.3	0.3	-0.6	-0.6	0.5	0.3	-0.3	0.3
Heel T-Score	0.2	1.7	6.8	1.3	-1.5	-0.9	0.1	-2.6	-2.3	0.3	0.0	0.5	-0.4	0.6	-1.7
Height	0.2	3.4	9.3	0.2	-3.0	0.9	0.6	-2.1	-2.6	1.9	1.7	-1.2	0.5	-2.1	-2.6
Hand grip strength (left)	0.2	0.6	2.6	0.9	-0.0	1.5	0.1	0.7	-0.1	-1.6	1.0	0.5	0.2	0.4	-0.2
Hand grip strength (right)	0.2	0.4	2.2	0.4	-0.7	1.1	-0.6	0.1	-0.4	-1.5	0.4	-0.3	-0.4	-0.1	-0.2
Sitting height	0.2	1.8	4.7	1.4	-1.6	1.2	1.0	-1.1	-2.0	0.7	1.8	-0.0	0.3	-0.6	-2.2
Diabetes (self-reported)	0.2	0.3	0.9	-0.6	0.5	1.0	0.6	0.8	-0.1	0.9	0.1	0.2	0.6	-0.1	-0.3
Trunk fat-free mass	0.2	1.3	6.1	2.5	-1.0	1.9	1.5	0.3	0.3	-0.8	-0.6	0.7	0.9	-0.4	0.2
Trunk predicted mass	0.2	1.3	6.0	2.5	-1.0	1.8	1.4	0.2	0.3	-0.9	-0.6	0.8	0.9	-0.4	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	-0.1	-0.8	0.9	-0.1	-0.4	-0.5	1.2	1.1	0.1	-0.6	-0.8	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.1	-0.5	0.4	0.7	-0.4	-0.5	0.2	0.1	0.6	0.5	-0.5	-0.3
Arm fat-free mass (right)	0.2	1.0	3.0	1.7	-0.0	1.5	1.6	0.1	0.4	-0.6	-1.2	1.1	1.0	-0.1	0.0
Emphysema/chronic bronchitis	0.2	0.3	0.7	0.9	-0.6	-0.8	-0.3	0.1	0.3	0.7	-0.3	0.1	-0.4	-0.2	0.4
Arm predicted mass (right)	0.2	1.0	3.4	1.8	-0.0	1.6	1.5	0.4	0.6	-0.7	-1.1	1.1	1.0	-0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.8	-0.2	-0.5	-0.4	-0.2	-0.2	-0.2	0.1	-1.4	-0.7	0.1	0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.1	0.3	-0.6	-0.5	0.2	-0.6	-0.6	-0.4	-0.2	-0.8	-0.7	-0.7
Diastolic blood pressure, automated reading	0.2	0.8	1.5	0.9	0.0	1.2	1.0	1.2	0.4	-1.2	-0.9	0.3	1.2	0.5	0.5
Blood Eosinophil Count	0.1	1.1	4.6	2.1	-0.7	-1.0	0.3	-0.3	1.3	0.5	1.6	0.5	0.3	-0.2	1.6
Blood Red Count	0.1	1.1	4.4	2.1	-0.1	-0.7	-0.0	1.3	1.7	-0.3	0.5	0.3	0.3	-0.2	1.8
Tanning	0.1	1.0	2.6	1.2	0.3	0.3	0.7	1.1	0.9	-0.0	-1.6	1.3	1.2	0.9	1.1
Heart attack	0.1	0.1	0.3	0.2	-0.5	0.1	-0.1	0.3	-0.3	-0.4	-0.4	-0.4	-0.0	0.5	0.3
Medication for pain relief, constipation, heartburn	0.1	0.3	1.3	1.2	-0.1	0.2	-0.4	0.4	0.1	-0.6	0.8	-0.3	0.0	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.3	-0.3	0.1	0.1	0.1	-0.1	-0.4	-0.3	-0.2	0.1	0.6	0.4
Hair Pigment	0.0	0.2	0.8	0.0	-0.4	0.1	-0.4	-0.9	-0.4	0.1	0.7	-0.7	-0.3	-0.1	-0.1

Hub : Genes

SGCD

Models

Trait associations