Hub : Genes

SGK223

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1170 0.0370 1.8e-05 0.003 0.034 0.033 0.035 0.019 1.3e-01 4.5e-05 5.4e-05 3.6e-05 2.0e-03
2 GTEx Esophagus Muscularis 0.1130 0.0450 2.3e-03 0.063 NA 0.023 NA 0.043 1.2e-04 NA 1.4e-02 NA 1.2e-03
3 GTEx Nerve Tibial 0.1693 0.0511 1.1e-05 0.019 NA 0.039 NA 0.040 1.7e-02 NA 8.9e-04 NA 8.1e-04
4 GTEx Testis 0.2910 0.0830 3.4e-05 0.020 NA 0.074 NA 0.015 4.1e-02 NA 3.5e-04 NA 6.6e-02
5 GTEx Thyroid 0.1920 0.0450 0.0e+00 0.352 NA 0.360 NA 0.353 5.7e-28 NA 1.1e-28 NA 4.6e-28
6 METSIM Adipose 0.0475 0.0207 4.2e-03 0.011 0.013 0.007 0.013 0.012 7.9e-03 4.5e-03 2.3e-02 3.4e-03 4.8e-03
7 ROSMAP Brain Pre-frontal Cortex 0.0735 0.0269 1.0e-06 0.023 0.050 0.029 0.048 0.024 4.7e-04 4.3e-07 9.7e-05 7.6e-07 3.5e-04
8 TCGA Lung Squamous Cell Carcinoma 0.0657 0.0290 6.4e-04 0.024 0.035 0.013 NA 0.024 8.9e-04 6.3e-05 1.0e-02 NA 8.4e-04
9 TCGA Prostate Adenocarcinoma 0.0578 0.0286 7.1e-03 0.046 0.013 0.029 NA 0.040 1.3e-05 1.6e-02 4.6e-04 NA 4.4e-05
10 TCGA Thyroid Carcinoma 0.1620 0.0500 0.0e+00 0.199 0.210 0.218 NA 0.217 4.2e-19 4.1e-20 6.1e-21 NA 7.8e-21

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.6 2.6 7.5 -1.6 -0.2 0.1 -2.2 -2.0 0.3 1.0 0.6 2.7 -2.4
Bipolar Disorder or Schizophrenia 3.7 9.0 19.4 -0.0 -2.4 -1.1 -4.4 -4.2 -0.8 3.1 -1.6 3.8 -4.4
Depressed Affect (Nagel 2018) 1.6 3.3 12.2 -0.7 0.1 -1.0 3.5 2.4 0.4 -2.3 0.7 -1.7 2.1
Depression (Nagel 2018) 1.1 1.7 6.0 0.2 0.4 -0.1 2.4 0.9 1.2 -1.9 0.8 -1.0 1.8
Intelligence (Savage-Jansen 2018) 0.4 1.2 5.7 -0.2 1.5 2.4 0.5 1.0 0.7 -0.1 0.9 0.5 1.0
Neuroticism (Nagel 2018) 1.5 3.5 11.8 0.7 0.0 -1.4 3.4 2.4 0.3 -2.2 1.2 -1.9 2.2
Schizophrenia (2018) 3.8 8.0 14.6 1.2 -2.9 -1.4 -3.8 -3.7 -1.3 3.1 -2.6 2.6 -3.7
Schizophrenia vs Biploar Disorder 1.2 1.6 3.4 0.1 -1.3 -1.3 -1.9 -1.5 -0.8 0.4 -1.8 -0.0 -1.7
Worry (Nagel 2018) 0.7 1.4 5.0 2.2 0.1 -1.4 2.0 1.2 0.3 -0.7 0.2 -0.5 0.8
Alzheimer’s Disease (in mother) 0.9 1.1 2.7 1.1 -0.8 -1.6 1.1 -0.6 -0.0 1.2 -0.7 -1.6 -0.2
Alzheimer’s Disease (in father) 0.3 0.3 1.0 1.0 -0.4 0.3 0.8 -0.0 -0.9 0.0 0.3 -0.4 0.4
Alzheimer’s Disease (including proxy) 0.8 1.2 2.9 1.7 -0.7 -1.2 1.6 -0.3 -0.7 1.0 -0.7 -1.7 0.3
Crohns Disease (2017) 0.4 0.9 2.5 -0.4 -0.3 0.2 -1.6 -1.3 -0.3 0.4 -1.5 -1.0 -1.2
Irritable Bowel Disease (IBD) 0.3 0.8 3.4 -0.9 -0.6 -0.2 -0.5 -0.4 -0.8 -0.4 -1.6 -1.9 -0.1
Ulcerative Colitis (UC) 0.3 0.6 2.5 -0.8 -0.5 -0.3 0.4 0.5 -0.5 -0.8 -0.8 -1.6 0.6
Major Depression (MDD) 0.5 0.6 3.2 1.8 -0.4 0.0 0.7 0.5 -0.7 -0.4 -0.7 -0.8 0.6
Reaction Time 0.5 1.0 2.4 -1.6 0.6 0.0 1.3 1.0 -1.5 -1.2 -0.4 -0.4 0.6
Verbal and Numeric Reasoning (VNR) 1.3 3.0 8.0 -0.2 2.3 2.8 1.2 1.6 2.2 -0.7 2.0 -1.0 1.7
Breast Cancer 1.2 2.9 7.1 -1.0 -1.5 -1.7 -1.9 -2.7 0.2 1.5 0.8 2.5 -1.7
Ovarian Cancer 0.6 0.8 3.8 -0.9 -1.9 -1.3 -0.4 -0.6 0.2 0.2 1.0 0.4 -0.3
Prostate Cancer 1.1 1.6 3.3 1.8 -1.4 -1.5 -1.4 -1.6 1.0 1.2 -0.3 0.2 -1.1
Age at First Birth 1.0 1.5 5.9 -1.1 1.6 1.3 -0.5 1.4 0.1 -2.4 0.8 0.1 1.0
Bipolar Disorder (2011) 1.8 1.7 5.7 -1.9 0.5 0.5 -1.6 -1.1 0.7 -0.1 1.4 2.4 -1.1
Body Mass Index (BMI) (2010) 2.3 3.1 7.4 -0.6 -1.9 -2.6 -2.1 -2.7 -0.6 0.9 -0.0 0.9 -2.7
Coronary Artery Disease (CAD) 0.4 0.4 2.1 0.2 0.1 0.1 -0.8 0.4 -1.4 0.1 -1.0 0.5 0.6
Crohns Disease (2012) 0.7 1.1 3.7 -1.6 -0.1 0.0 -1.9 -1.3 -0.5 0.1 -0.8 -0.5 -1.3
Mean Putamen Volume 1.9 2.2 7.0 1.1 -1.5 -1.5 -0.3 -0.7 -2.6 1.3 -2.6 0.2 -0.5
Fasting Glucose 1.1 1.3 4.7 0.7 -0.2 -0.6 -0.9 -1.6 0.2 1.3 0.5 2.2 -1.3
HbA1C 0.7 0.8 2.3 -1.5 -0.4 -0.6 -1.3 -0.7 -1.0 0.7 0.1 0.4 -1.0
HDL Cholesterol 0.6 1.0 2.2 1.5 -0.8 -1.0 0.9 1.1 0.2 -1.2 0.6 -0.7 1.3
LDL Cholesterol 0.4 0.6 1.5 -0.9 -1.2 -0.5 -1.0 -1.0 0.2 0.1 1.2 0.1 -0.6
Lupus 7.2 11.0 19.5 1.1 -4.3 -3.6 -3.9 -4.4 -2.2 3.6 -2.3 1.3 -4.1
Neuroticism (2016) 13.8 19.8 55.7 0.4 3.3 2.4 6.1 7.5 1.9 -6.0 2.5 -2.1 6.2
Primary Biliary Cirrhosis 1.6 2.3 6.2 2.5 -2.3 -1.6 -1.3 -1.8 -0.6 1.5 -0.6 -0.1 -1.2
Rheumatoid Arthritis 0.5 0.7 3.6 -0.3 -1.5 -1.9 0.1 -0.3 -0.9 0.2 -0.4 -0.5 -0.4
Schizophrenia (2014) 4.2 9.3 21.8 -0.2 -2.2 -1.1 -4.6 -4.5 -1.1 3.3 -2.6 2.5 -4.7
Triglycerides 2.8 4.6 15.3 2.1 0.3 1.6 2.8 3.1 -0.1 -1.6 -0.0 -1.9 3.9
Type 2 Diabetes (T2D) (2012) 2.8 3.2 6.3 0.7 -2.0 -2.4 -2.5 -2.1 0.9 1.6 -0.1 1.3 -2.3
Ulcerative Colitis 1.1 1.6 4.7 -0.5 0.4 -0.0 1.4 1.5 -0.7 -1.5 -0.8 -1.9 2.2
Blood Eosinophil Count 0.1 0.9 2.7 -0.9 1.4 0.7 0.0 1.2 -1.2 -0.0 -0.2 1.6 -0.4
Blood Platelet Count 0.1 0.9 5.0 -0.9 0.9 1.0 1.1 -0.5 0.5 0.3 -0.3 -2.2 -0.1
Blood Red Count 0.2 2.0 5.4 1.8 -0.8 0.0 1.5 0.0 -1.4 1.8 -1.9 -0.6 2.3
Blood White Count 0.1 0.7 2.7 -1.0 0.8 -0.0 1.1 0.8 -0.5 -0.0 -0.4 -1.6 -0.8
Heel T-Score 0.6 5.0 29.4 2.5 0.3 0.4 -0.7 -0.6 -3.1 1.6 -5.4 -0.1 -1.1
BMI 0.2 1.3 4.0 -0.5 -2.0 -2.0 -0.0 0.6 -1.7 -0.9 0.2 0.5 0.3
Height 0.2 3.9 16.7 -0.7 2.1 2.8 -2.4 0.8 0.3 -1.6 0.3 4.1 0.7
Waist Hip Ratio (WHR) 0.4 1.6 5.2 -0.3 1.4 1.7 -0.3 0.4 2.3 0.5 2.0 1.1 -0.9
Systolic Blood Pressure 0.2 0.9 3.5 1.9 0.3 0.5 0.1 1.2 -1.0 0.3 -0.8 -1.1 0.9
Smoking Status 0.8 1.8 5.7 1.1 -1.1 -0.7 0.8 0.8 -2.4 -1.3 -1.6 -1.3 1.5
Allergy or Eczema 0.6 1.5 4.6 -1.8 1.0 -0.1 -0.1 0.3 -2.1 -0.4 -1.5 0.8 -1.6
Cardiovascular Disease 0.4 1.4 4.0 1.4 -0.2 -0.6 0.5 1.1 -2.0 -0.1 -1.4 -1.4 1.7
Hypothyroidism (self reported) 1.6 3.7 22.5 1.6 1.3 1.2 1.0 4.7 -1.6 -0.4 -0.9 0.3 2.1
Respiratory disease 1.0 2.3 6.4 1.1 0.5 0.1 -1.3 -2.2 -0.2 2.3 -1.9 0.4 -2.5
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.1 0.0 -1.1 -1.6 -0.6 0.1 0.0 -1.2 1.8 1.5 0.0
Lung FEV1/FVC ratio 0.3 1.7 7.9 2.8 -1.2 -0.1 -0.6 0.7 0.8 -0.4 1.7 -0.3 1.7
Lung FVC 0.2 0.9 4.1 0.0 -0.7 -1.5 0.5 -0.9 -0.3 -0.3 -0.8 -2.0 0.3
Neuroticism 0.4 1.0 5.6 0.4 0.1 -1.0 2.4 0.3 0.5 -0.4 0.4 -1.3 0.8
Chronotype (morning person) 2.0 4.7 16.5 -0.3 0.2 0.8 -2.0 -1.3 4.1 0.6 3.0 3.1 -2.3
Hair Pigment 0.1 1.5 7.3 -0.5 1.5 0.4 -0.0 -0.2 2.7 -1.8 1.0 -0.5 -0.2
Tanning 0.1 1.0 4.0 -1.0 0.2 1.0 -1.2 -0.9 -0.5 1.1 -2.0 -0.5 -0.3
Hand grip strength (left) 1.1 2.8 10.1 3.2 -2.3 -1.8 -1.0 -1.5 -1.0 1.7 -1.4 -0.7 0.2
Number of treatments/medications taken 0.6 1.1 3.1 0.0 -1.0 -1.1 -1.8 -0.8 0.5 0.3 1.5 0.6 -1.4
Average weekly spirits intake 0.6 0.7 2.8 1.0 0.4 0.4 0.6 1.7 0.6 -0.7 0.5 -0.4 1.2
Sensitivity / hurt feelings 6.9 11.8 30.1 1.6 1.2 0.9 4.3 5.4 0.4 -4.5 1.9 -3.3 5.5
Frequency of depressed mood in last 2 weeks 4.9 6.9 22.3 0.3 2.2 1.2 4.7 3.3 1.0 -3.1 1.5 -1.4 3.8
Hearing difficulty/problems: Yes 0.6 0.9 3.2 0.1 0.5 -0.4 1.5 0.9 -0.5 -1.1 -0.9 -1.8 0.5
Relative age of first facial hair 0.3 0.5 1.8 1.3 -0.8 -0.5 0.9 0.3 0.4 -0.6 -0.3 -1.1 0.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 3.8 -1.1 -0.4 -0.3 -0.0 0.7 0.1 -1.5 1.9 -0.2 1.0
Ever used hormone-replacement therapy (HRT) 1.3 1.7 6.0 1.4 1.2 1.0 -0.9 -1.2 -0.2 2.5 -1.3 0.5 -1.5
Ever had hysterectomy (womb removed) 1.9 2.2 5.9 -0.9 -0.2 -0.2 -2.1 -2.4 0.8 2.4 0.2 0.6 -2.0
Systolic blood pressure, automated reading 5.7 16.6 34.7 0.6 -3.3 -3.4 -5.2 -5.9 -2.4 5.6 -2.9 1.7 -5.7
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.3 -0.1 0.1 0.8 0.0 0.1 1.5 -0.1 0.9 -0.8 1.5
Angina 0.3 0.4 1.3 -1.0 -0.8 -0.8 -0.4 -0.3 -0.7 0.3 0.0 -1.2 -0.2
Medication for hormone replacement therapy 0.9 1.0 2.3 0.4 0.7 0.7 -1.0 -1.5 -0.6 1.5 -0.8 0.8 -1.4
Vitamin and mineral supplements 1.8 2.4 5.7 1.2 -1.2 -0.4 2.2 2.3 -0.5 -1.5 -0.1 -1.7 2.4
Supplements: Zinc 2.4 2.6 7.0 -0.8 0.5 0.8 -2.2 -2.4 -0.3 1.1 -0.1 2.6 -2.3
Medication: Co-codamol 1.6 1.8 3.7 1.6 -1.9 -1.9 -0.9 -1.1 -0.9 1.4 -1.6 0.5 -0.9
Medication: Metformin 1.4 2.0 4.2 0.7 -1.5 -1.4 -2.0 -1.9 -0.1 1.7 0.4 1.2 -1.6
Diabetes (father) 2.5 3.2 6.8 -0.7 -2.2 -1.9 -2.3 -2.6 0.7 2.1 0.0 -0.1 -2.4
Diabetes (mother) 0.4 0.5 1.2 -1.0 -0.4 -0.8 -0.4 -1.1 0.8 0.1 0.3 -0.5 -0.8
Severe depression (siblings) 0.3 0.3 1.1 -0.5 -0.4 -0.5 0.9 -1.0 -0.5 0.4 0.0 0.1 -0.3
Pack years adult smoking proportion 1.7 2.7 5.5 0.9 -1.9 -1.4 -2.4 -2.2 -0.6 2.0 -0.0 1.3 -2.0
Impedance of leg (right) 6.0 28.9 84.5 3.0 3.9 3.1 6.2 9.2 -0.2 -6.4 1.1 -4.2 8.5
Leg fat-free mass (left) 2.6 14.0 34.3 -1.1 -3.0 -2.2 -5.1 -5.9 -0.7 4.2 -0.6 4.4 -5.2
Trunk fat percentage 1.1 4.4 10.9 0.7 -2.3 -1.9 -2.5 -2.5 -1.3 3.3 -0.9 1.9 -2.3
Hand grip strength (right) 0.8 2.2 7.4 2.7 -1.8 -1.2 -0.6 -1.2 -0.5 1.3 -1.1 -2.1 0.6
Townsend deprivation index at recruitment 0.7 1.0 2.8 1.1 1.3 1.7 0.5 0.5 0.1 0.1 0.3 1.7 0.7
Current tobacco smoking 4.3 7.0 13.8 0.6 -3.0 -2.3 -2.4 -3.7 -2.6 3.1 -2.6 0.7 -3.5
Average weekly fortified wine intake 1.5 1.7 4.3 -0.1 1.4 2.1 -0.2 1.8 -1.3 -1.0 -0.1 0.6 2.1
Maternal smoking around birth 0.5 0.7 1.6 1.1 0.9 0.3 0.6 1.1 -0.4 -1.2 0.2 1.0 1.0
Fed-up feelings 9.5 17.3 42.1 0.8 2.4 0.8 6.5 6.4 0.3 -5.5 1.6 -3.1 6.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.4 10.7 1.8 1.6 0.5 3.3 2.1 1.0 -2.1 0.2 -0.5 2.7
Relative age voice broke 0.4 0.6 3.3 1.8 0.0 0.8 0.1 0.3 1.2 -0.4 -0.4 0.2 0.3
Taking other prescription medications 0.6 0.9 3.0 0.7 -1.7 -1.4 -0.8 -0.0 -0.3 0.8 0.7 1.1 0.2
Age when periods started (menarche) 1.0 2.4 8.6 -1.1 1.2 0.6 1.7 2.9 0.4 -2.9 -0.0 -0.6 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 0.5 0.4 0.5 -1.2 -1.4 0.5 1.3 0.4 0.5 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 14.8 33.7 86.8 -0.4 -4.7 -4.7 -6.8 -9.3 -1.7 6.8 -4.2 3.6 -8.9
Tinnitus: Yes, but not now, but have in the past 2.0 2.2 4.3 -0.6 -2.0 -2.1 -1.6 -1.7 -1.7 0.4 -1.4 -1.1 -1.3
Qualifications: CSEs or equivalent 1.1 1.4 9.7 3.1 -1.0 -0.5 0.5 -0.1 -0.2 0.7 -1.3 -0.3 0.8
Serious illness, injury or assault to yourself 1.9 2.3 3.7 -0.6 1.1 0.9 1.6 1.7 1.2 -1.9 1.7 -1.8 1.9
High blood pressure 5.2 14.6 35.5 0.1 -3.0 -3.0 -5.3 -6.0 -1.5 4.9 -1.4 2.5 -5.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.5 -0.9 0.3 -0.4 -0.6 -0.5 -1.9 -0.1 -1.0 1.3 -1.6
Multivitamins +/- minerals 0.6 0.8 2.3 -1.0 1.0 0.0 -0.8 -1.5 -0.4 0.8 -0.4 0.5 -1.4
Stomach or abdominal pain in last month 1.9 2.4 10.8 3.3 -0.2 -0.4 1.0 2.1 0.2 -0.6 -0.4 -1.6 2.2
Supplements: Glucosamine 0.5 0.7 1.9 0.3 0.2 0.7 -0.5 -0.4 1.3 1.2 1.4 0.7 0.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 7.9 -2.8 1.3 0.4 -0.4 -0.0 -0.2 -1.8 0.5 -1.5 0.1
Medication: Atenolol 2.1 2.6 7.2 -0.4 -1.1 -0.8 -2.0 -2.7 -1.4 2.1 -1.6 1.0 -1.9
Medication: Levothyroxine sodium 6.5 10.9 39.7 0.7 2.6 2.6 2.5 6.3 -1.4 -4.1 0.9 -1.5 5.3
Sitting height 1.0 6.9 28.3 -0.7 0.9 1.7 -4.1 -3.0 0.4 1.8 0.4 5.3 -2.7
Chronic bronchitis/emphysema (father) 0.4 0.4 2.0 -1.4 1.0 0.6 0.6 0.2 0.6 -0.1 0.3 0.1 0.0
High blood pressure (mother) 1.9 2.7 8.5 -1.6 0.3 0.2 -1.5 -2.3 -1.1 2.4 -1.1 0.4 -2.9
Body mass index (BMI) 6.5 27.7 63.4 -0.4 -5.3 -4.8 -6.2 -8.0 -2.2 6.8 -2.5 3.6 -7.4
Impedance of leg (left) 6.4 30.9 91.8 2.9 3.9 3.1 6.4 9.6 0.2 -7.1 1.4 -4.2 8.5
Leg predicted mass (left) 2.6 14.0 33.8 -1.0 -3.0 -2.1 -5.1 -5.8 -0.6 4.2 -0.5 4.5 -5.2
Trunk fat mass 1.7 7.3 14.3 0.6 -2.7 -2.1 -3.6 -3.5 -0.9 3.8 -0.6 3.0 -3.2
Waist circumference 1.1 4.1 10.4 -0.4 -1.9 -1.4 -3.1 -2.2 -0.5 1.8 0.6 3.2 -2.5
Number of incorrect matches in round 0.1 0.2 0.8 0.5 -0.3 0.1 -0.2 0.2 -0.0 -0.9 0.1 0.4 0.6
Past tobacco smoking 1.6 2.9 4.9 -1.9 2.1 1.6 2.0 2.2 1.3 -2.1 1.7 0.2 0.8
Alcohol usually taken with meals 2.1 3.4 8.2 -1.5 0.3 1.0 -2.9 -2.2 1.0 1.7 0.8 2.4 -2.7
Nervous feelings 11.0 20.5 54.2 2.5 4.0 2.8 6.0 7.4 1.0 -5.2 1.6 -2.6 6.8
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.5 8.8 0.0 2.4 0.9 3.0 2.0 1.7 -2.6 1.3 -0.6 2.0
Hearing difficulty/problems with background noise 1.1 1.7 4.7 -0.6 0.8 0.3 2.2 1.2 0.4 -1.4 1.4 -1.9 1.4
Hair/balding pattern: Pattern 2 0.8 1.0 3.8 0.6 -1.0 -0.3 -0.1 -1.4 -0.2 1.9 -1.4 -0.9 -0.6
Had menopause 1.6 2.0 6.0 -0.4 -0.0 -0.2 -2.4 -1.4 0.4 1.4 0.4 2.4 -2.0
Had other major operations 2.1 2.5 10.9 -0.9 -0.1 -0.9 -2.0 -2.3 -0.4 1.0 -0.6 1.3 -3.3
Forced vital capacity (FVC) 1.4 5.2 14.5 0.2 1.5 1.4 3.3 3.1 -0.4 -2.7 -0.3 -2.3 3.8
Heel bone mineral density (BMD) T-score, automated (right) 16.2 37.2 87.2 -0.7 -5.7 -5.9 -7.8 -9.3 -2.7 6.5 -3.4 3.6 -9.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 -1.3 0.8 -0.2 1.0 0.3 0.3 -1.1 1.1 0.8 0.7
Qualifications: None of the above 0.5 1.0 3.0 1.3 -0.8 -0.4 0.8 0.1 -1.7 1.2 -1.4 0.4 0.5
Financial difficulties in last 2 years 0.9 1.2 4.8 2.2 -0.9 -1.2 -0.7 -0.8 0.3 1.1 -1.4 0.3 -0.7
Mouth/teeth dental problems 4.1 6.2 14.3 -1.1 2.9 3.1 2.2 3.8 0.3 -2.5 1.1 -1.6 3.7
Heart attack 1.0 1.3 3.7 -0.0 -1.7 -1.7 -0.5 0.5 -1.9 -1.0 0.9 -0.5 1.0
Allergy 1.8 4.1 12.4 0.7 0.7 1.4 2.2 2.4 2.5 -1.6 1.6 -1.9 3.5
Pain all over the body in last month 1.7 1.9 5.5 0.3 -1.6 -1.2 -2.3 -2.0 0.8 0.4 0.3 1.7 -1.0
Diabetes (self-reported) 0.6 1.0 2.7 0.1 -1.5 -1.6 -0.8 -1.3 -0.5 0.8 0.6 0.9 -0.7
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 4.4 -0.9 1.8 1.4 1.3 2.1 -0.5 -1.0 0.7 0.0 1.1
Medication: Ramipril 1.7 2.2 4.6 1.2 -2.1 -1.4 -1.7 -2.0 -0.7 1.6 -1.2 0.5 -1.4
Medication: Simvastatin 1.6 2.3 6.9 -0.6 -1.7 -2.4 -2.6 -1.2 -0.3 -0.0 1.2 1.1 -1.8
Fluid intelligence score 1.2 2.5 6.5 0.1 2.1 2.5 0.6 1.4 2.1 -0.6 1.6 -1.5 1.4
Illnesses of siblings 1.2 1.6 3.5 -1.8 1.4 1.8 0.8 0.6 0.6 -1.5 1.9 0.2 1.0
Neuroticism score 16.1 33.6 79.2 1.9 4.1 2.9 8.3 8.9 1.6 -7.0 2.8 -4.5 8.9
Weight 2.5 12.5 25.3 -0.4 -3.3 -2.7 -4.8 -5.0 -1.4 4.1 -1.1 4.0 -4.7
Impedance of arm (right) 6.9 32.1 79.5 1.2 5.7 5.0 6.9 8.9 1.0 -6.5 2.1 -4.0 8.5
Arm fat percentage (right) 3.2 12.6 25.4 0.7 -4.0 -3.6 -4.0 -5.0 -2.2 5.0 -1.7 2.3 -4.2
Trunk fat-free mass 1.2 6.6 17.0 -0.6 -2.2 -1.4 -4.1 -3.7 -0.2 2.1 0.2 3.8 -3.0
Hip circumference 2.6 11.1 23.3 -0.5 -3.3 -2.6 -4.8 -4.7 -1.6 3.3 -0.8 3.8 -4.2
Time employed in main current job 2.9 3.3 7.8 0.1 1.7 1.3 -0.1 2.8 2.3 -2.3 2.6 -0.5 1.8
Alcohol intake versus 10 years previously 1.0 1.5 5.1 1.2 -2.3 -1.3 0.7 0.7 -0.4 -1.2 0.7 -0.4 1.8
Father’s age at death 6.6 8.9 15.3 -0.8 3.6 3.6 3.0 3.7 2.6 -2.5 2.5 -2.2 3.9
Worrier / anxious feelings 15.2 28.7 74.3 3.6 4.1 3.4 7.1 8.6 1.2 -5.6 2.3 -3.0 8.6
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 8.1 2.0 0.2 0.5 2.8 2.4 -0.7 -1.5 -0.3 -0.6 2.6
Falls in the last year 0.3 0.4 1.3 0.3 -1.2 -1.1 0.6 -0.3 -0.7 0.1 -0.2 -0.1 -0.4
Hair/balding pattern: Pattern 3 1.6 2.4 10.5 -1.4 -0.4 -0.3 -0.3 0.8 2.5 -2.1 3.2 0.1 0.2
Number of live births 0.3 0.5 3.1 -0.2 1.7 0.6 0.4 0.4 -0.0 0.0 -0.9 0.2 -0.5
Forced expiratory volume in 1-second (FEV1) 3.0 10.2 28.2 1.1 1.6 1.5 4.5 4.8 -0.0 -4.0 0.3 -2.9 5.3
Pulse rate 1.0 1.7 5.2 -0.3 1.1 1.3 0.4 2.2 -0.3 -2.3 0.6 0.5 1.7
Happiness 0.5 0.7 2.1 0.8 -0.9 -1.0 -0.5 -0.0 -1.2 -0.2 0.3 1.5 0.4
Noisy workplace 2.3 2.8 8.6 1.0 -2.9 -2.8 1.3 1.1 -2.4 -0.4 -0.6 -0.6 1.0
Qualifications: A levels/AS levels or equivalent 3.8 8.3 25.6 -2.1 5.1 4.7 1.0 2.7 2.5 -2.8 2.2 -0.2 1.8
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 7.3 -1.1 1.7 2.2 2.7 2.5 1.9 -2.0 1.7 -0.4 2.3
Mouth/teeth dental problems: Dentures 6.4 10.7 17.5 1.1 -3.2 -2.9 -3.9 -4.2 -2.9 3.9 -2.6 2.9 -4.0
Asthma 1.9 3.8 12.6 -0.1 0.3 -0.0 -2.3 -3.1 -0.4 2.6 -1.0 1.5 -3.6
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 6.4 0.6 0.6 0.8 1.8 1.3 0.1 -0.4 -0.5 -2.5 1.4
Medication: Cholesterol lowering 0.9 1.4 2.9 -1.0 -1.4 -1.4 -1.7 -1.2 0.1 0.1 1.3 0.5 -1.5
Depression (self-reported) 1.6 1.9 8.9 -0.5 0.8 0.2 3.0 1.7 -0.5 -1.5 0.3 -0.9 1.7
Medication: Lansoprazole 0.9 1.0 2.1 1.1 -1.3 -0.5 -1.1 -1.0 -0.8 1.4 -0.2 1.3 -0.8
Prospective memory result 0.8 1.0 3.9 1.5 -0.8 -1.1 -0.4 -0.2 -0.8 0.6 -2.0 0.5 -0.3
Lung cancer (father) 0.3 0.3 0.8 0.9 0.3 0.9 0.7 0.3 -0.1 0.6 -0.7 0.6 -0.2
Illnesses of mother 0.9 1.1 2.5 -0.7 0.9 1.2 -1.0 -0.0 1.4 -1.3 1.6 1.2 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.9 9.4 23.7 1.0 1.2 1.1 4.3 4.5 0.5 -4.1 1.2 -3.0 4.9
Pulse wave Arterial Stiffness index 0.9 1.0 2.4 1.0 -1.6 -0.9 -1.2 -0.9 -0.0 1.5 -1.1 0.3 -0.7
Impedance of arm (left) 6.0 27.9 67.2 1.1 5.7 5.4 6.1 8.2 1.6 -5.9 2.3 -3.4 7.7
Arm fat mass (right) 3.9 15.9 34.8 0.3 -4.1 -3.3 -4.9 -5.9 -1.9 5.5 -1.8 3.2 -5.1
Trunk predicted mass 1.2 6.7 17.4 -0.6 -2.2 -1.4 -4.2 -3.6 -0.1 2.1 0.3 3.9 -3.0
Standing height 1.3 13.2 30.1 0.0 4.0 4.4 2.3 5.5 1.6 -4.8 2.5 1.6 5.1
Length of working week for main job 1.9 2.1 6.0 1.1 -2.5 -2.1 -1.0 -2.2 -0.0 1.1 -1.0 -0.6 -1.1
Exposure to tobacco smoke at home 0.8 0.9 1.9 -0.9 -0.6 -1.0 -1.4 -0.7 -1.2 -0.3 -1.4 -0.6 -0.7
Breastfed as a baby 0.8 1.0 2.5 -0.2 1.4 1.0 0.4 1.6 1.2 -1.4 0.1 0.4 1.0
Tense / ‘highly strung’ 9.1 15.0 38.7 2.1 2.2 1.2 6.2 5.9 0.4 -4.3 1.6 -2.9 6.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 6.5 0.6 0.6 0.2 2.5 1.9 -0.1 -1.5 0.2 -0.1 1.5
Hair/balding pattern: Pattern 4 0.4 0.9 2.4 -1.6 1.4 1.0 -0.6 0.2 0.1 -0.9 0.1 1.4 -0.6
Birth weight of first child 1.0 1.8 9.4 3.1 0.1 0.5 1.4 1.5 0.6 1.3 -0.4 -0.2 1.2
Peak expiratory flow (PEF) 4.7 10.8 28.6 1.1 1.3 1.3 4.4 5.3 0.8 -4.5 1.2 -2.5 5.1
Pulse wave reflection index 2.5 3.1 8.0 1.0 -1.9 -1.5 -1.4 -2.5 -1.3 2.8 -2.2 -0.9 -1.0
Ever highly irritable/argumentative for 2 days 1.4 1.7 3.3 -0.9 1.8 1.6 1.7 1.3 0.4 -0.4 1.5 -0.7 1.8
Loud music exposure frequency 0.9 1.0 2.5 1.3 0.9 1.1 -0.7 -1.1 0.8 1.6 0.6 0.9 0.5
Qualifications: O levels/GCSEs or equivalent 4.5 7.1 16.0 -2.5 3.1 3.2 1.5 3.0 2.3 -4.0 2.2 -1.5 2.3
Mouth/teeth dental problems: Bleeding gums 3.4 4.4 10.9 0.0 -2.7 -3.0 -0.8 -3.2 0.9 1.9 -0.8 -0.7 -3.3
Blood clot in the leg (DVT) 1.7 2.3 6.3 -1.1 -1.7 -0.8 -2.5 -1.8 -1.4 1.8 -0.1 0.4 -1.7
Medication: Paracetamol 2.4 3.9 11.2 0.2 -0.9 -1.8 2.6 2.3 -1.6 -2.6 0.2 -3.4 1.5
Headache pain in last month 3.4 5.8 19.9 2.0 1.2 -0.1 4.5 3.4 -0.1 -2.4 -0.1 -2.4 3.1
Medication for cholesterol, blood pressure or diabetes 1.7 2.7 7.1 0.7 1.4 1.2 2.6 2.2 -0.9 -1.2 -1.1 -1.1 2.7
Glaucoma (self-reported) 1.0 1.2 3.1 0.8 -1.5 -1.8 -0.7 -0.6 -1.3 0.7 -1.5 0.4 -0.6
Gout (self-reported) 0.6 0.9 4.6 0.0 -2.1 -1.7 -0.5 -0.3 -0.6 -0.3 0.5 -0.3 -0.4
Hypothyroidism/myxoedema (self-reported) 9.4 18.4 66.3 0.9 4.1 4.1 3.7 8.1 -0.3 -4.9 1.5 -0.7 6.5
Medication: Amlodipine 1.8 2.5 5.5 -1.0 -1.9 -2.1 -1.2 -1.9 -1.5 0.1 -1.0 -1.5 -2.4
Medication: Ventolin 100micrograms inhaler 1.2 1.5 5.4 0.5 -0.6 -0.6 -2.3 -0.9 0.1 1.1 -0.2 1.9 -1.6
Birth weight 0.6 1.3 5.0 0.7 -0.9 -0.7 -2.2 -0.9 0.8 1.3 0.3 1.3 -1.0
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.4 2.1 -1.3 -1.2 0.0 0.7 -1.2 0.3 -2.0 -0.0 0.5
High blood pressure (siblings) 1.8 2.6 8.1 2.1 -1.5 -1.8 -0.5 -0.7 -1.0 1.7 -2.8 -1.6 -1.0
Forced vital capacity (FVC), Best measure 1.1 3.9 10.3 0.8 0.6 0.6 3.2 2.6 -0.5 -2.3 0.0 -2.2 3.2
Body fat percentage 1.9 7.5 14.3 0.6 -3.1 -2.8 -3.4 -3.5 -1.6 3.8 -1.1 2.2 -3.2
Leg fat percentage (right) 3.3 11.9 19.7 1.4 -4.4 -4.0 -4.0 -4.4 -2.0 4.3 -1.5 2.2 -3.9
Arm fat-free mass (right) 2.2 11.3 25.9 -0.8 -3.1 -2.3 -5.1 -4.7 -0.7 3.2 -0.2 4.4 -4.4
Exposure to tobacco smoke outside home 0.6 0.8 2.9 -1.6 0.1 -0.6 0.5 1.0 0.1 -1.7 0.3 -0.8 0.6
Comparative body size at age 10 4.8 13.4 36.4 -2.4 -4.1 -3.5 -4.0 -6.0 0.2 3.6 -0.3 1.6 -5.5
Number of full brothers 1.6 2.0 6.8 1.0 -1.2 -1.1 -0.8 -2.4 1.2 2.6 -0.6 -0.1 -1.3
Worry too long after embarrassment 11.0 18.4 41.3 0.5 2.9 2.2 6.2 6.2 1.9 -4.8 2.6 -4.3 6.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.4 0.9 0.1 1.1 1.2 -0.2 1.2 0.2 0.8 0.8 1.1
Wheeze or whistling in the chest in last year 3.0 5.3 10.5 0.2 -2.8 -2.8 -2.3 -3.2 -1.7 2.7 -0.9 1.4 -2.9
Number of children fathered 2.0 2.3 5.9 0.5 -0.7 -1.2 -2.4 -1.5 -1.6 1.5 -1.8 0.5 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.7 -1.8 1.2 1.9 0.5 1.0 0.7 -1.4 1.0 -0.6 1.3
Age at first live birth 2.7 4.8 9.2 -1.6 2.3 2.2 2.0 2.8 1.7 -3.0 1.8 -0.9 2.8
Pulse wave peak to peak time 1.4 1.6 3.8 -1.1 2.0 1.3 1.4 1.3 -0.1 -1.8 1.1 -0.3 1.0
Health satisfaction 2.5 3.2 8.4 -1.8 -0.6 -1.0 -1.2 -2.9 -1.7 2.1 -1.1 1.9 -2.4
Shortness of breath walking on level ground 0.6 0.7 1.4 -0.5 -0.8 -0.9 -0.6 -0.7 -1.2 1.0 -1.2 0.4 -0.9
Qualifications: College or University degree 0.8 2.5 6.3 -2.4 2.5 2.1 -0.1 1.2 1.5 -1.4 1.7 0.3 0.3
Eye problems/disorders: None of the above 1.0 1.1 5.1 0.0 1.1 0.7 2.3 1.0 0.1 -0.2 0.5 -1.6 0.6
Mouth/teeth dental problems: Loose teeth 3.3 4.0 10.1 1.4 -2.5 -2.7 -1.2 -3.2 -0.4 2.3 -1.2 -0.1 -2.5
Emphysema/chronic bronchitis 6.4 7.2 14.8 2.5 -2.9 -1.8 -3.3 -3.8 -0.7 3.7 -1.8 1.9 -2.7
Medication for pain relief, constipation, heartburn 0.7 1.1 4.0 0.1 0.8 1.2 -0.8 -1.1 1.2 1.2 -0.6 2.0 -0.6
Neck or shoulder pain in last month 0.5 0.8 2.8 0.2 0.8 0.7 1.7 0.9 -0.5 -0.4 -0.7 -0.3 1.4
Medication: Blood pressure 2.4 4.3 12.4 -0.5 -1.3 -0.8 -3.3 -3.3 1.1 2.2 0.4 0.9 -3.5
Angina (self-reported) 0.3 0.4 1.2 -0.7 -1.1 -0.9 -0.6 -0.4 -0.1 0.5 0.4 -0.9 -0.3
Migraine (self-reported) 0.6 0.7 2.4 0.0 -0.7 -0.4 1.5 0.6 0.4 -1.0 -0.2 -1.4 0.6
Medication: Ibuprofen 0.8 1.0 3.6 0.3 0.7 0.7 1.5 1.3 0.0 -0.4 -0.2 -1.9 1.1
Medication: Allopurinol 0.8 1.1 3.6 -0.6 -1.9 -1.6 -1.1 -1.1 0.0 0.2 0.8 -0.0 -1.2
Medication: Omeprazole 0.6 0.8 2.1 0.2 -1.2 -1.4 -0.1 -0.6 -1.4 0.5 -1.0 -0.7 -0.2
Medication: Seretide 50 evohaler 1.1 1.3 2.9 -0.3 0.4 0.5 -0.9 -1.7 1.2 1.2 1.7 1.3 -1.3
Mean time to correctly identify matches 0.4 0.7 5.4 -2.3 0.0 -0.6 0.7 0.0 -0.7 -0.7 0.0 -0.1 -0.2
Heart disease (mother) 0.2 0.3 0.6 0.5 -0.5 -0.2 0.7 0.6 0.5 0.4 0.8 0.4 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.4 5.2 9.9 -0.2 2.7 2.3 2.8 3.2 2.2 -2.0 1.9 -1.5 2.7
Whole body fat mass 2.5 10.4 19.8 0.2 -3.3 -2.7 -4.3 -4.5 -1.2 4.2 -1.0 3.2 -4.2
Leg fat mass (right) 4.3 16.7 31.9 0.5 -4.7 -4.0 -5.2 -5.7 -2.0 4.9 -1.5 3.6 -5.1
Arm predicted mass (right) 2.4 12.3 27.4 -0.7 -3.4 -2.7 -5.2 -5.0 -0.5 3.4 -0.2 4.2 -4.6
Pulse rate, automated reading 0.3 0.9 2.5 1.6 -1.3 -1.3 -1.1 0.3 -1.1 0.3 -0.5 0.2 -0.3
Alcohol intake frequency. 0.2 0.4 1.8 -0.3 -0.2 -0.2 0.2 0.4 -1.3 -0.6 1.0 0.8 0.5
Comparative height size at age 10 0.2 1.0 5.1 0.6 0.1 0.6 -1.6 -0.8 0.4 0.0 0.9 2.2 -0.4
Number of full sisters 2.0 2.5 6.2 -0.3 -2.1 -2.5 -1.3 -1.8 -1.9 1.2 -0.6 0.6 -1.9
Suffer from ‘nerves’ 7.2 11.3 32.1 2.1 2.6 1.3 4.9 4.9 0.2 -3.6 0.7 -2.4 5.7
Overall health rating 4.1 8.8 17.1 1.1 -3.1 -3.6 -2.9 -4.1 -2.8 3.5 -1.8 2.1 -3.4
Chest pain or discomfort 0.3 0.4 1.2 1.1 -0.8 -0.3 0.3 -0.2 0.8 1.0 0.4 0.4 0.2
Had major operations 0.3 0.3 1.5 0.1 -0.4 -0.7 0.4 0.1 -1.2 -0.3 0.4 0.8 0.1
Age at last live birth 4.0 5.8 11.9 -0.7 2.4 2.1 2.6 3.4 1.7 -3.5 2.0 -1.2 3.1
Family relationship satisfaction 1.0 1.3 5.7 1.1 0.1 -0.3 2.4 0.6 -1.4 1.0 -0.1 -0.8 1.3
Leg pain on walking 1.9 2.4 4.7 -1.1 -1.7 -2.2 -2.1 -1.3 -1.3 0.8 -1.3 1.5 -1.7
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 6.1 0.9 -1.0 -1.5 -0.1 -0.2 -2.5 -0.5 -1.8 -0.1 -0.8
Commuting to job workplace: Car/motor vehicle 1.1 1.3 6.3 0.1 -1.4 -1.5 -0.6 -0.7 0.3 0.6 -0.5 -2.5 -0.9
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 5.0 -0.0 -1.5 -1.2 -2.2 -1.7 -1.2 1.5 -0.5 0.5 -1.6
Medication: Aspirin 2.3 3.1 7.5 -0.5 -2.0 -1.9 -2.4 -2.7 -0.1 2.1 1.1 0.5 -2.0
Supplements: Vitamin C 3.1 3.7 11.3 0.2 -0.2 -0.7 -3.4 -2.5 0.6 1.7 -0.3 2.8 -2.8
Knee pain experienced in last month 0.5 0.7 1.8 -1.0 -1.0 -0.4 0.2 -1.4 0.6 0.9 -0.2 -0.7 -1.2
Hypertension (Self-reported) 5.4 15.1 37.0 0.5 -3.0 -2.9 -5.3 -6.1 -1.6 5.4 -1.6 2.2 -5.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.5 1.9 0.2 0.4 -0.5 -0.5 -0.0 1.1 -1.6 1.8 -0.1
Illnesses of father: Heart disease 0.8 1.0 4.9 1.0 1.2 0.2 -0.1 -0.2 -1.0 1.2 -2.2 -0.0 -0.8
Illnesses of siblings: Diabetes 0.8 1.0 2.7 0.1 -0.0 0.4 -0.3 -1.6 1.1 1.6 0.6 0.8 -1.5
Smoking status: Previous 0.4 0.6 1.3 1.1 -0.7 -0.2 -1.1 -0.9 -0.2 1.1 -0.6 -0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 5.2 1.5 1.4 1.4 1.1 2.3 0.5 -2.2 1.5 1.4 2.2
Whole body fat-free mass 1.8 10.3 22.7 -0.9 -2.8 -1.9 -4.8 -4.7 -0.6 3.1 -0.2 4.4 -4.1
Leg fat-free mass (right) 2.5 13.4 32.7 -1.3 -2.8 -1.9 -4.9 -5.7 -0.4 3.9 -0.4 4.6 -5.2
Arm fat percentage (left) 3.4 13.5 28.0 0.3 -3.9 -3.2 -4.4 -5.3 -1.8 5.2 -1.3 2.8 -4.7
Average weekly red wine intake 2.0 2.9 11.1 -0.4 0.5 0.8 -2.0 -2.1 -0.4 3.3 -1.5 0.6 -2.3
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.0 0.6 0.6 0.4 0.0 -0.5 -1.1 0.9 -1.4 0.3 -0.3
Mood swings 6.1 11.0 27.5 0.3 2.8 1.9 5.1 5.2 0.2 -4.3 0.3 -2.4 4.5
Loneliness, isolation 1.4 2.0 7.6 0.3 0.9 0.6 2.7 1.3 1.2 -1.1 0.7 -1.3 2.1
Long-standing illness, disability or infirmity 0.4 0.5 1.6 -0.3 0.6 0.4 -1.2 -0.7 -0.2 0.2 1.0 1.2 -0.5
Ever had bowel cancer screening 1.2 1.4 4.6 -0.8 1.1 0.5 0.1 1.3 1.5 -2.1 1.9 0.3 0.4
Diabetes diagnosed by doctor 1.4 2.4 5.8 0.2 -2.3 -2.4 -1.6 -1.7 -0.4 0.8 1.1 1.8 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 8.5 0.1 -0.7 -1.1 -2.2 -2.9 -0.2 1.8 -0.7 1.7 -2.9
Friendships satisfaction 1.5 1.9 7.8 -0.1 -1.7 -2.8 1.8 -0.0 -1.9 -0.5 -0.3 -0.9 0.3
Qualifications: nursing, teaching 1.5 2.4 6.8 -1.6 2.6 2.6 -0.4 0.5 2.0 -1.1 1.1 -0.6 0.6
Commuting to job workplace: Walk 1.7 1.8 7.8 -2.8 1.3 1.2 0.0 -0.2 0.0 -0.8 0.4 2.3 -0.8
Eye problems/disorders: Cataract 0.8 1.0 4.1 -0.1 -1.0 -0.5 -1.7 -0.2 -0.8 0.2 0.4 2.0 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 5.2 -0.4 1.0 0.4 1.8 2.0 1.3 -2.3 0.9 -1.2 1.2
Medication for cholesterol 3.2 4.8 6.7 -1.6 2.1 2.3 2.5 2.4 2.4 -2.6 1.8 -1.5 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 0.4 -0.3 -0.1 0.2 -0.3 -0.8 -0.5 -0.2 0.4 -0.7
Back pain experienced in last month 0.8 1.2 4.3 1.3 -1.3 -2.1 -0.3 -0.2 -1.0 -0.4 -1.4 -0.8 -0.3
Mineral and other dietary supplements 4.0 5.4 16.4 0.8 0.2 0.1 2.4 4.1 -2.8 -3.1 -1.5 -1.7 2.9
Breast cancer (self-reported) 1.8 2.2 11.9 0.0 1.3 1.3 -0.9 -0.4 3.5 0.7 1.2 1.8 -0.5
Asthma (self-reported) 2.2 4.3 13.4 0.1 -0.1 -0.3 -2.7 -3.3 -0.5 2.8 -0.8 1.8 -3.7
Osteoporosis (self-reported) 3.5 4.4 13.4 -0.5 2.1 2.0 2.1 3.7 1.5 -1.8 2.0 -0.4 2.7
Osteoarthritis (self-reported) 1.0 1.3 2.4 -0.4 -1.4 -1.3 -1.2 -0.8 -1.2 0.5 -0.6 1.6 -1.5
Medication: Aspirin 1.9 2.5 5.6 -0.6 -2.2 -2.2 -1.7 -2.4 -0.1 1.6 1.3 -0.0 -1.5
Medication: Gliclazide 0.7 0.7 1.7 -0.9 -1.2 -0.9 -0.7 -0.5 -1.3 -0.3 -0.4 -1.0 -0.8
Illnesses of father: None of the above (group 1) 0.9 1.1 3.2 1.0 -0.9 -0.1 0.9 1.8 -0.1 -1.5 0.3 -0.3 1.6
Smoking status: Current 4.4 6.9 14.0 0.6 -3.2 -2.3 -2.3 -3.7 -2.5 2.9 -2.6 0.7 -3.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 13.0 0.8 0.5 0.7 2.2 3.6 0.6 -2.7 0.7 -2.4 3.6
Whole body water mass 1.8 10.4 23.0 -0.9 -2.7 -1.9 -4.8 -4.8 -0.5 3.1 -0.2 4.3 -4.1
Leg predicted mass (right) 2.5 13.5 32.5 -1.3 -2.8 -2.0 -5.0 -5.7 -0.4 3.9 -0.3 4.6 -5.3
Arm fat mass (left) 4.0 16.3 34.2 0.2 -4.2 -3.3 -5.1 -5.8 -1.9 5.4 -1.6 3.4 -5.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 0.7 0.4 0.6 -1.2 -0.3 1.2 0.6 1.3 0.8 -0.6
Average weekly champagne plus white wine intake 1.0 1.3 3.3 0.1 0.5 0.1 -1.3 -0.7 1.7 0.8 1.3 1.8 -1.5
Miserableness 8.6 14.8 39.4 0.7 1.9 1.1 6.0 6.3 1.1 -5.0 2.1 -2.5 5.5
Guilty feelings 6.8 10.3 24.4 0.8 2.6 2.4 4.1 4.9 1.9 -3.6 1.2 -2.8 4.8
Wears glasses or contact lenses 1.2 1.4 7.1 -2.7 1.4 0.9 -0.1 0.5 1.2 -0.6 1.2 0.6 0.3
Ever taken oral contraceptive pill 0.5 0.5 2.1 -0.4 1.0 0.5 0.6 1.0 0.0 -1.5 -0.2 0.7 -0.0
Hearing aid user 0.2 0.2 0.8 0.4 0.1 0.0 -0.9 -0.1 0.3 0.7 0.1 0.7 -0.6
Mother’s age at death 1.9 2.4 5.7 -0.3 1.6 1.3 2.4 2.1 0.7 -1.2 0.8 -1.7 2.1
Financial situation satisfaction 0.8 1.0 2.4 -0.1 -1.4 -1.3 -0.7 -1.2 -1.6 0.9 -0.6 0.7 -0.5
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.8 0.6 -0.2 -0.1 0.8 1.7 0.5 -1.2 1.0 -0.9 1.4
Commuting to job workplace: Public transport 2.1 2.5 6.4 -0.1 1.8 1.5 2.5 2.4 -0.2 -1.7 0.9 -0.2 1.9
Eye problems/disorders: Glaucoma 1.9 2.2 5.3 1.2 -1.9 -2.0 -1.5 -1.2 -1.7 1.0 -2.3 0.4 -0.8
Medication: Blood pressure 5.7 10.9 27.0 0.2 -2.7 -3.0 -4.5 -5.2 -2.2 3.8 -1.8 2.2 -4.3
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.5 -0.1 -1.1 -1.3 -1.7 -1.3 -0.7 1.1 -0.6 1.4 -1.9
Supplements: Fish oil (including cod liver oil) 4.3 5.7 18.4 1.0 -1.8 -1.9 -2.5 -4.3 0.7 3.6 -0.8 0.3 -3.3
High cholesterol (Self-reported) 1.6 2.9 7.1 0.3 -2.7 -2.6 -2.3 -1.7 -0.7 0.9 -0.1 1.8 -1.3
Medication: Bendroflumethiazide 6.1 9.3 23.9 -0.8 -2.9 -3.3 -3.6 -4.9 -1.3 3.2 -2.1 0.6 -4.4
Medication: Paracetamol 2.2 3.5 9.8 0.7 -1.1 -2.0 2.2 2.2 -1.9 -1.9 -0.4 -3.1 1.2
Medication: Lisinopril 1.4 1.7 5.6 0.3 -1.3 -1.6 -1.1 -2.4 -0.7 1.5 -0.3 -0.7 -1.7
Medication: Atorvastatin 0.6 0.7 3.1 -0.9 -1.2 -0.7 -0.0 -0.1 -1.8 0.1 -1.1 -0.1 0.0
Illnesses of father: High blood pressure 0.7 0.8 2.4 -0.4 -0.3 -1.4 -0.7 -1.6 0.0 0.9 -0.6 -0.5 -1.4
Alcohol drinker status: Never 1.7 2.0 6.4 -1.1 1.4 1.8 0.3 1.4 1.3 -1.0 2.5 1.2 1.2
Ever smoked 1.5 2.7 6.5 2.6 -1.8 -1.4 -1.0 -1.0 -2.1 1.6 -2.4 -0.7 -0.0
Basal metabolic rate 2.0 11.3 24.9 -0.7 -3.0 -2.2 -4.8 -5.0 -0.8 3.5 -0.4 4.3 -4.3
Leg fat percentage (left) 3.3 11.9 20.0 1.4 -4.4 -4.0 -4.2 -4.5 -1.6 4.2 -1.3 2.3 -4.2
Arm fat-free mass (left) 2.1 10.5 23.9 -0.5 -3.3 -2.6 -4.9 -4.7 -0.9 3.0 -0.4 3.9 -4.0
Number of operations (self-reported) 2.7 4.0 10.4 -0.4 -1.1 -1.1 -2.8 -2.7 -1.6 1.8 -1.3 2.1 -3.2
Average weekly beer plus cider intake 4.7 6.9 20.4 1.6 0.4 0.1 2.8 4.5 -0.9 -4.5 -0.2 -1.9 3.7
Irritability 15.5 26.3 64.0 1.9 3.1 1.6 6.4 8.0 0.3 -7.3 2.3 -5.2 7.6
Risk taking 3.4 4.9 9.5 1.3 -2.4 -3.0 -2.1 -3.1 -1.1 2.2 -1.9 0.5 -3.0
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.3 -0.7 -0.3 -1.1 -0.4 0.2 -0.7 -0.4 -0.7 -0.7 -0.7
Fractured/broken bones in last 5 years 2.1 2.7 8.0 -1.4 0.8 0.4 1.5 1.3 2.7 -2.1 2.8 -0.2 0.7
Age started oral contraceptive pill 0.9 1.2 3.6 -0.2 1.9 1.6 0.2 1.6 0.4 -0.8 0.6 1.0 0.8
Diastolic blood pressure, automated reading 6.4 19.9 42.8 0.5 -3.8 -4.1 -5.1 -6.5 -2.0 6.5 -3.2 1.6 -6.3
Ever depressed for a whole week 2.0 2.5 5.1 -1.0 2.0 1.6 2.2 2.3 1.1 -1.6 1.1 0.3 1.6
Unable to work because of sickness or disability 2.3 3.0 5.7 0.6 -1.6 -2.0 -1.1 -2.3 -2.0 2.4 -2.2 -0.0 -1.4
Commuting to job workplace: Cycle 0.3 0.3 1.2 -1.0 1.1 0.5 0.5 -0.0 -0.2 0.1 -0.2 -0.5 0.5
Myopia 1.9 2.8 7.0 1.1 1.4 1.4 2.6 1.6 2.4 -1.4 1.5 -1.1 1.5
Vascular/heart problems diagnosed by doctor 4.4 11.9 28.0 0.3 2.5 2.7 4.9 5.3 1.9 -4.4 1.3 -2.0 5.0
Cholesterol lowering medication 1.1 1.6 6.7 1.5 -2.2 -2.6 -0.7 0.3 -1.3 0.2 -0.6 0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.6 -0.0 -1.1 -1.3 0.4 -0.1 -1.6 -0.1 -0.6 -0.9 0.2
Pain experienced in last month 0.6 1.1 2.3 -1.5 1.5 1.2 -1.2 0.0 0.8 -0.2 1.1 0.9 -0.6
Supplements: Calcium 1.6 1.8 7.8 -0.9 1.0 1.2 -0.7 0.1 1.8 -0.3 1.6 2.8 -0.6
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.4 0.0 -0.1 -0.4 -0.3 -0.8 0.4 -0.6 0.8 -0.7
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.3 -0.1 -1.8 -1.8 -0.6 0.4 -1.8 -1.0 1.0 -0.4 0.9
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 8.8 -1.1 -1.5 -0.5 -3.0 -2.1 -0.9 2.0 0.2 1.2 -1.8
Heart disease (siblings) 0.4 0.5 1.5 -0.4 -0.8 -1.1 0.3 1.2 -0.6 -0.8 0.5 0.6 -0.5
Alcohol drinker status: Previous 0.2 0.3 1.3 0.6 -0.2 -0.3 -0.4 0.0 -1.1 -0.5 -0.5 0.6 -0.3
Pack years of smoking 1.4 2.0 4.2 0.6 -1.8 -1.4 -2.1 -1.7 -0.5 1.6 0.1 1.5 -1.7
Impedance of whole body 6.8 34.6 93.8 2.0 5.3 4.7 6.9 9.7 0.8 -7.0 1.9 -4.3 8.8
Leg fat mass (left) 4.2 16.3 31.1 0.4 -4.6 -3.9 -5.2 -5.6 -1.9 4.8 -1.3 3.6 -5.2
Arm predicted mass (left) 2.2 11.4 23.7 -0.5 -3.5 -2.9 -4.8 -4.9 -1.1 3.2 -0.6 4.1 -4.2