TWAS hub - SGMS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0270	1.1e-03	0.003	0.026	0.007	0.029	0.007	1.2e-01	0.00035	4.2e-02	0.00016	3.9e-02
2	GTEx	Cells Transformed fibroblasts	0.2040	0.0490	3.7e-08	0.043	NA	0.064	NA	0.073	3.4e-04	NA	1.4e-05	NA	3.9e-06
3	GTEx	Spleen	0.2090	0.0870	4.8e-03	0.016	NA	0.060	NA	0.043	1.3e-01	NA	1.2e-02	NA	2.9e-02
4	GTEx	Whole Blood	0.1480	0.0530	2.0e-03	0.000	NA	0.017	NA	0.009	3.4e-01	NA	9.8e-03	NA	4.7e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.0401	0.0174	1.6e-03	0.035	0.029	0.015	0.027	0.024	2.4e-05	0.00010	4.1e-03	0.00017	4.2e-04
6	TCGA	Breast Invasive Carcinoma	0.0386	0.0166	2.4e-04	0.022	0.010	0.008	NA	0.013	1.7e-05	0.00300	8.3e-03	NA	7.2e-04
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.1260	0.0560	1.6e-03	0.033	0.021	0.017	NA	0.039	2.5e-03	0.01300	2.5e-02	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood clot in the leg (DVT)	3.7	4.8	13.2	3.1	3.6	-1.5	1.8	2.2	0.0	-0.5
Medication: Ibuprofen	3.6	4.3	14.1	-1.4	0.6	-2.4	-0.7	1.2	2.4	-3.8
Glaucoma (self-reported)	3.3	3.8	8.5	2.2	2.4	1.1	2.9	1.3	-1.4	-1.6
Body Mass Index (BMI) (2010)	3.1	4.2	17.1	1.5	2.2	-0.3	0.3	4.1	-0.6	-2.1
Multivitamins +/- minerals	3.1	3.9	6.8	2.6	2.6	1.1	1.9	1.1	-1.3	-2.5
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	14.0	-0.9	1.1	-2.5	0.2	1.4	1.8	-3.7
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	10.3	2.3	3.2	-1.8	1.4	1.8	0.3	-0.2
Ever had hysterectomy (womb removed)	2.5	2.8	8.4	2.9	2.3	-0.5	1.0	1.8	-1.2	0.0
Vitamin and mineral supplements	2.5	3.3	6.5	-2.5	-2.5	-1.4	-1.2	-1.4	1.5	1.8
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	7.6	1.4	1.4	-1.8	1.2	2.1	1.3	-2.8
Eye problems/disorders: Glaucoma	2.3	2.7	4.8	1.3	1.9	1.6	2.2	1.7	-0.8	-1.7
Mouth/teeth dental problems	2.2	3.3	14.0	-2.1	-1.4	3.7	1.6	0.3	-0.4	-0.2
Vascular/heart problems diagnosed by doctor	2.2	6.0	15.5	3.9	3.1	0.4	1.1	2.3	-3.0	-1.2
High blood pressure	2.0	5.7	13.8	-3.7	-2.8	-0.5	-1.1	-2.0	3.5	0.7
Pain all over the body in last month	2.0	2.1	5.3	-0.7	0.7	-2.2	-2.3	0.8	1.6	-0.8
Eye problems/disorders: Cataract	2.0	2.3	8.8	0.2	-0.3	0.6	-3.0	1.0	-0.9	2.2
Alzheimer’s Disease (in father)	1.9	2.1	4.4	1.8	0.6	1.9	1.2	1.2	-2.1	0.2
Qualifications: CSEs or equivalent	1.9	2.5	6.3	-1.5	-0.4	1.1	-2.1	-1.2	-1.3	2.5
Mean Putamen Volume	1.8	2.1	6.4	1.2	-0.4	1.5	0.1	-1.4	-2.5	1.5
Ulcerative Colitis	1.8	2.6	7.3	-1.4	-2.7	1.2	-1.4	-1.2	1.8	0.8
Peak expiratory flow (PEF)	1.8	4.1	7.8	-2.8	-1.9	-0.3	-2.5	2.8	1.7	0.1
Wheeze or whistling in the chest in last year	1.8	3.2	7.5	1.1	2.7	-1.5	0.3	2.2	1.0	-2.3
Medication for pain relief, constipation, heartburn	1.8	3.0	8.4	0.7	-1.6	2.9	-0.3	-1.0	-1.2	2.6
Hypothyroidism (self reported)	1.7	3.9	11.6	0.2	1.9	0.1	0.4	3.4	1.8	-2.9
Lung FEV1/FVC ratio	1.7	8.4	28.0	1.0	3.0	0.0	0.1	5.3	1.2	-4.4
Body mass index (BMI)	1.7	7.1	14.4	3.2	3.3	-3.8	-0.8	3.0	1.4	-1.5
Medication: Blood pressure	1.7	3.1	7.5	-2.5	-2.7	1.3	0.3	-2.1	1.0	0.8
Hypertension (Self-reported)	1.7	4.8	13.2	-3.6	-2.5	-0.2	-0.5	-1.8	3.2	0.3
Medication: Aspirin	1.7	2.3	6.8	0.8	0.5	-2.6	2.4	-1.2	0.9	-0.4
Arm fat mass (left)	1.7	6.8	13.2	2.4	3.1	-3.6	-0.8	3.1	2.1	-2.0
Systolic Blood Pressure	1.6	8.0	15.1	-3.8	-3.9	2.2	-1.7	-2.7	0.8	3.2
Supplements: Zinc	1.6	1.7	3.7	1.3	-0.2	1.4	0.5	-1.5	-1.9	1.4
Waist circumference	1.6	6.0	9.6	2.1	2.5	-3.1	0.1	3.0	2.1	-2.8
Nervous feelings	1.6	3.1	6.4	-1.8	-2.0	1.5	-0.0	-2.5	-0.5	2.3
Mouth/teeth dental problems: Dentures	1.6	2.6	12.4	0.7	0.8	-3.5	-2.0	0.4	0.9	0.0
Arm fat mass (right)	1.6	6.5	13.5	2.4	2.9	-3.7	-0.9	3.0	2.2	-1.7
Financial situation satisfaction	1.6	2.0	5.3	1.5	2.3	-2.3	-0.1	0.5	0.0	-1.0
Relative age of first facial hair	1.5	3.1	5.9	2.4	2.4	0.5	1.3	1.1	-2.3	-1.1
Medication: Co-codamol	1.5	1.7	4.6	-1.4	0.3	-1.3	-2.1	0.6	1.7	0.7
Townsend deprivation index at recruitment	1.5	2.1	8.3	0.2	1.1	-2.9	0.4	0.4	1.9	-1.1
Allergy	1.5	3.6	5.3	-1.2	-1.8	2.2	-1.5	-2.1	-2.3	1.9
Number of live births	1.5	2.1	6.3	0.2	1.7	-0.2	0.1	2.3	0.2	-2.5
Whole body fat mass	1.5	6.3	14.6	2.3	2.6	-3.8	-1.3	2.9	2.1	-1.7
Leg fat mass (right)	1.5	5.7	11.4	2.3	2.8	-3.4	-1.4	3.0	1.5	-1.4
Family relationship satisfaction	1.5	1.9	7.5	0.8	0.8	-2.7	1.0	-1.4	1.2	0.1
Arm fat percentage (left)	1.5	5.8	11.7	2.9	2.9	-3.4	-0.7	2.3	1.8	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.8	-0.7	1.1	-0.9	0.0	2.2	1.2	-1.9
Leg fat mass (left)	1.5	5.9	10.6	2.3	2.8	-3.3	-1.5	3.1	1.6	-1.6
Neuroticism (2016)	1.4	2.0	5.6	-2.1	-2.4	0.8	-1.0	-0.6	1.0	1.1
Pack years adult smoking proportion	1.4	2.1	7.7	-0.3	0.9	-1.9	-2.8	1.0	1.2	0.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.0	-1.9	-2.2	0.8	-0.8	-0.6	0.9	0.7
Happiness	1.4	1.7	3.4	1.6	0.1	1.7	1.5	-0.7	-1.8	0.5
Medication: Aspirin	1.4	1.9	5.6	1.4	1.1	-1.9	2.4	-0.7	-0.1	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.5	-1.8	-0.1	-0.4	-2.1	1.6	0.4	-0.8
Ever smoked	1.4	2.4	6.6	-0.6	-0.5	-2.6	1.1	-1.9	2.2	-0.3
BMI	1.3	7.8	15.0	3.0	3.0	-3.9	-0.9	3.7	1.8	-2.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	4.2	1.6	1.2	0.8	0.6	1.0	-2.0	0.2
Diabetes (father)	1.3	1.6	5.5	1.4	1.7	-0.7	2.3	-0.1	-0.5	0.3
Current tobacco smoking	1.3	2.1	5.4	2.2	1.7	-2.3	0.9	0.3	0.3	-0.8
Past tobacco smoking	1.3	2.3	8.6	0.4	0.1	2.9	-1.2	1.0	-2.1	0.6
Arm fat percentage (right)	1.3	5.1	10.2	2.7	2.9	-3.2	-0.7	2.1	1.7	-1.2
Supplements: Vitamin C	1.3	1.5	3.6	1.6	1.0	1.6	0.7	0.3	-1.9	-0.8
Osteoarthritis (self-reported)	1.3	1.7	6.5	0.5	1.1	-0.5	-1.4	2.6	-0.4	1.1
Number of self-reported non-cancer illnesses	1.3	2.3	7.0	-0.7	0.6	-1.1	-0.9	2.0	2.6	-1.6
Myopia	1.3	1.8	4.5	-2.1	-1.6	-1.4	-0.1	-1.1	1.6	-0.7
Alzheimer’s Disease (in mother)	1.2	1.4	5.0	0.0	0.1	-2.2	-1.0	-1.1	1.2	1.2
HbA1C	1.2	1.3	3.0	-1.0	-1.1	-1.2	-0.0	-0.5	1.7	-1.6
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.8	0.9	-0.6	-1.8	0.1	-2.0	0.5	1.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.8	1.4	2.0	0.5	1.1	1.0	-0.8	0.5
Hayfever, allergic rhinitis or eczema	1.2	2.7	5.2	1.4	1.2	-0.8	1.4	2.3	1.6	-2.2
Trunk fat mass	1.2	5.3	11.4	2.0	2.2	-3.4	-1.7	2.8	2.1	-1.5
Medication: Simvastatin	1.2	1.8	3.4	-1.9	-1.3	-0.1	1.6	-1.7	1.3	-0.3
Weight	1.2	6.0	13.0	1.7	2.6	-3.3	-1.3	3.6	1.8	-1.7
Length of working week for main job	1.2	1.3	2.6	1.1	1.5	-1.4	0.8	-0.0	-0.2	-1.6
Pulse wave reflection index	1.2	1.5	4.4	1.2	0.5	1.1	2.1	-0.8	-1.2	-0.9
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.7	2.1	2.2	-0.9	0.1	1.8	-0.4	-0.3
Heart disease (mother)	1.2	1.5	5.6	-1.6	-0.3	1.1	-2.4	0.5	0.6	0.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.5	0.1	-0.1	1.1	0.2	-2.1	-1.8	0.9
Loneliness, isolation	1.2	1.6	3.9	1.8	0.7	1.7	0.8	0.3	-2.0	0.3
Smoking status: Current	1.2	1.9	4.2	1.9	1.6	-2.0	1.3	0.5	0.4	-0.9
Medication: Blood pressure	1.2	2.2	5.0	-2.2	-1.3	-0.9	1.2	-1.3	2.2	-0.1
Illnesses of father: High blood pressure	1.2	1.5	4.4	-2.1	-1.5	-1.0	0.4	-0.7	1.3	0.8
Pack years of smoking	1.2	1.7	7.9	-0.3	0.5	-1.4	-2.8	0.6	0.8	0.9
Worry (Nagel 2018)	1.1	2.4	5.0	-1.6	-2.0	1.7	-0.9	-0.9	-0.9	2.2
Ulcerative Colitis (UC)	1.1	2.0	5.2	-1.3	-2.1	0.9	-0.9	-1.1	2.3	0.4
Age at First Birth	1.1	1.6	5.1	-1.7	-2.3	0.1	-0.9	-1.4	0.2	0.7
Systolic blood pressure, automated reading	1.1	3.2	6.3	-2.3	-2.5	0.6	-2.2	-1.5	0.5	1.7
Hip circumference	1.1	4.9	18.3	1.6	2.0	-4.3	-1.1	1.3	2.2	-1.2
Alcohol intake versus 10 years previously	1.1	1.6	4.5	-0.5	0.7	-2.1	-0.9	1.2	1.3	-1.4
Worrier / anxious feelings	1.1	2.1	4.1	-2.0	-1.3	2.0	-1.1	0.4	-0.3	1.9
Prospective memory result	1.1	1.3	3.2	1.5	1.8	0.5	-0.0	0.6	-1.5	-0.8
Illnesses of mother	1.1	1.3	3.0	0.9	0.6	-1.1	1.7	1.1	0.6	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.1	0.3	1.6	-0.4	0.4	2.3	0.2	-1.9
Body fat percentage	1.1	4.3	11.2	2.2	2.0	-3.3	-1.7	1.9	1.8	-1.0
Exposure to tobacco smoke outside home	1.1	1.5	3.8	1.9	1.9	-0.3	0.4	1.3	-0.8	-0.5
Pulse wave peak to peak time	1.1	1.3	3.7	-1.8	-0.8	-0.7	-1.9	-0.1	0.9	0.2
Back pain experienced in last month	1.1	1.6	4.0	1.8	1.4	-2.0	0.2	0.1	0.3	-1.3
Medication: Lisinopril	1.1	1.4	3.3	-1.5	-0.9	1.4	-1.8	-0.0	0.4	1.0
Number of operations (self-reported)	1.1	1.7	5.2	2.3	1.7	-0.8	0.4	0.2	-1.4	1.0
Irritable Bowel Disease (IBD)	1.0	2.3	8.4	-1.9	-1.2	0.8	-1.0	0.3	2.9	-0.8
Bipolar Disorder (2011)	1.0	1.0	4.2	-1.1	-0.6	-0.6	0.4	0.6	2.1	0.3
Allergy or Eczema	1.0	2.7	6.5	2.1	1.6	-0.2	0.7	2.6	0.4	-2.1
Angina	1.0	1.3	2.3	-1.1	-1.5	1.5	0.8	-0.6	-0.1	1.5
Medication for hormone replacement therapy	1.0	1.1	3.5	0.2	1.1	0.7	-1.3	1.9	-0.2	-0.9
Trunk fat percentage	1.0	3.9	9.9	2.0	1.8	-3.1	-1.6	1.9	1.9	-1.0
Relative age voice broke	1.0	1.5	3.7	1.6	1.2	0.8	1.4	0.2	-1.9	-0.0
Hair/balding pattern: Pattern 2	1.0	1.3	4.1	-1.5	-2.0	1.4	-0.5	0.1	0.0	0.7
Diabetes (self-reported)	1.0	1.6	4.5	2.1	0.8	0.3	2.1	-0.0	-1.1	-0.0
Falls in the last year	1.0	1.4	3.5	1.1	-0.1	1.9	0.6	1.0	-1.4	1.2
Pulse wave Arterial Stiffness index	1.0	1.2	3.3	1.8	0.9	0.5	1.8	0.2	-0.8	-0.2
Birth weight of first child	1.0	1.9	3.0	1.6	0.5	0.5	1.5	-1.6	-1.7	1.5
Birth weight	1.0	2.1	8.3	1.5	0.9	-2.9	1.2	-1.2	0.7	0.2
Worry too long after embarrassment	1.0	1.8	4.5	-1.8	-1.5	2.1	-0.4	-1.0	-0.3	1.1
Number of children fathered	1.0	1.2	2.6	0.6	1.6	-1.6	-0.5	1.3	0.7	-0.4
Health satisfaction	1.0	1.3	3.7	1.9	-0.7	-0.7	0.8	-1.6	-0.6	0.9
Ever taken oral contraceptive pill	1.0	1.1	4.2	2.0	0.6	-1.3	-0.0	-1.1	-0.2	0.1
Hearing aid user	1.0	1.2	3.0	-1.6	-1.2	0.1	-1.0	0.3	1.7	-0.5
Leg fat percentage (left)	1.0	3.5	8.1	2.1	1.7	-2.9	-1.9	1.9	1.3	-0.5
Alcohol drinker status: Previous	1.0	1.2	2.3	1.0	1.5	-0.3	1.1	1.1	0.7	-1.3
Rheumatoid Arthritis	0.9	1.3	3.0	-0.8	0.1	0.1	-0.4	1.6	1.7	-1.7
Triglycerides	0.9	1.5	8.2	-0.3	1.1	0.7	0.6	2.9	0.0	-0.2
Respiratory disease	0.9	2.0	7.7	0.6	2.0	-0.5	-0.9	2.8	0.2	-1.2
Impedance of leg (right)	0.9	4.5	9.3	-3.0	-3.0	1.7	-0.9	-2.7	-0.3	1.4
Leg fat-free mass (left)	0.9	5.0	13.6	1.0	2.4	-2.7	-0.8	3.7	1.8	-1.9
Maternal smoking around birth	0.9	1.2	3.6	1.6	0.9	-1.1	0.1	0.4	-0.6	1.9
Fed-up feelings	0.9	1.6	6.0	1.5	2.4	-0.1	0.0	1.3	-0.8	-0.6
Medication: Levothyroxine sodium	0.9	1.6	4.8	-0.2	0.5	0.3	0.5	1.6	2.2	-1.7
Impedance of leg (left)	0.9	4.4	9.0	-2.8	-3.0	1.7	-1.1	-2.8	-0.4	1.2
Leg predicted mass (left)	0.9	4.8	12.7	1.0	2.3	-2.7	-0.7	3.6	1.8	-1.9
Heart attack	0.9	1.1	3.4	-0.6	-0.9	-0.7	0.4	-1.5	-0.5	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	5.7	0.5	0.4	-0.4	1.1	2.4	0.3	-0.2
Lung cancer (father)	0.9	1.0	2.9	1.0	1.7	-0.4	-0.7	1.0	-0.7	-1.1
Headache pain in last month	0.9	1.5	5.6	0.6	0.7	-1.0	0.5	0.3	1.7	-2.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.1	0.0	1.1	-0.4	0.2	2.0	2.0	-1.8
Leg fat percentage (right)	0.9	3.4	8.5	2.0	1.7	-2.9	-1.8	1.9	1.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.2	-1.8	-1.1	0.2	-0.2	-1.6	-0.3	0.5
Eye problems/disorders: None of the above	0.9	1.1	2.7	-1.0	-0.2	-1.3	0.7	-1.2	1.6	-0.3
Neck or shoulder pain in last month	0.9	1.3	3.9	0.7	1.2	2.0	-0.4	1.4	-1.0	-0.2
Angina (self-reported)	0.9	1.2	2.2	-1.0	-1.5	1.4	1.0	-0.8	-0.1	1.2
Medication: Omeprazole	0.9	1.1	5.1	0.0	0.1	-0.8	-2.2	1.1	0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.0	-1.2	1.7	0.8	-1.4	0.8	0.2	0.3
Friendships satisfaction	0.9	1.2	2.8	1.3	0.4	-0.7	1.6	-1.7	-0.6	0.3
Risk taking	0.9	1.3	4.6	0.5	0.3	-1.9	0.3	0.0	2.1	-0.7
Cholesterol lowering medication	0.9	1.4	4.4	-0.2	-0.3	-1.5	2.1	-1.3	1.0	-0.2
Crohns Disease (2017)	0.8	1.9	5.2	-1.3	0.4	0.2	-0.1	1.5	2.3	-1.8
HDL Cholesterol	0.8	1.3	5.7	0.5	-0.1	-1.1	1.3	-2.4	0.1	0.2
Severe depression (siblings)	0.8	0.9	3.3	-0.5	0.3	1.8	0.3	0.4	-1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.9	1.2	0.6	1.0	0.6	0.5	-1.7	0.6
Medication: Atenolol	0.8	1.1	2.6	-1.6	-1.2	-0.6	-0.6	-1.6	0.4	-0.3
Qualifications: None of the above	0.8	1.7	8.7	-0.1	0.1	-3.0	0.1	-0.7	1.2	-1.0
Medication: Ramipril	0.8	1.1	3.4	-0.4	-0.3	-0.3	1.8	-1.4	-0.5	1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	8.9	-0.1	-0.6	0.6	3.0	-0.9	1.0	-1.0
Arm fat-free mass (right)	0.8	3.9	13.8	0.4	1.8	-2.1	-1.3	3.7	1.1	-1.5
Medication: Allopurinol	0.8	1.1	2.1	-0.5	-0.1	-1.3	-1.4	1.1	1.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.6	1.1	0.7	-0.6	1.2	0.6	0.1	-1.6
Arm predicted mass (right)	0.8	3.8	13.6	0.1	1.7	-2.0	-1.2	3.7	1.4	-1.7
Leg fat-free mass (right)	0.8	4.3	12.0	0.8	2.2	-2.5	-0.8	3.5	1.7	-1.8
Commuting to job workplace: Walk	0.8	0.9	2.0	-1.4	-1.4	0.2	0.4	-1.2	0.7	-0.7
Leg predicted mass (right)	0.8	4.4	11.6	0.8	2.2	-2.6	-0.8	3.4	1.8	-1.8
Miserableness	0.8	1.3	3.5	-0.5	1.5	0.2	-0.6	1.7	0.0	-1.9
Basal metabolic rate	0.8	4.7	13.6	0.4	2.1	-2.6	-1.1	3.7	1.9	-1.9
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.1	-0.5	-1.0	-0.9	0.2	-1.4	-0.4	1.8
Heart disease (siblings)	0.8	0.9	1.8	-0.3	0.9	-1.3	-1.2	1.2	0.5	-1.0
Coronary Artery Disease (CAD)	0.7	0.9	2.2	0.7	-0.7	-0.1	1.4	-1.5	-0.0	0.9
Cardiovascular Disease	0.7	2.5	7.1	-2.7	-1.3	-0.3	0.5	-1.4	2.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.5	1.0	0.3	0.7	0.1	-1.5	-1.6	0.1
High blood pressure (mother)	0.7	1.0	1.8	-0.0	-1.1	1.1	0.7	-1.2	-0.8	1.3
Forced vital capacity (FVC)	0.7	2.8	8.7	-2.7	-1.4	-0.2	-3.0	1.0	0.6	0.8
Financial difficulties in last 2 years	0.7	0.9	4.3	0.4	0.4	-2.1	0.2	0.2	1.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.5	-2.0	-0.5	-0.3	-2.1	2.6	1.1	-0.2
Breastfed as a baby	0.7	0.9	2.9	-0.1	0.7	-1.3	0.8	-0.1	0.6	-1.7
Medication: Amlodipine	0.7	1.0	3.2	-0.8	-1.0	-0.4	0.4	-1.0	1.0	-1.8
Forced vital capacity (FVC), Best measure	0.7	2.7	6.1	-2.5	-2.3	-0.1	-2.3	0.2	0.6	1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.7	1.6	0.5	-0.2	-0.5	-0.7	-0.8	1.1
Age at last live birth	0.7	1.1	4.0	-0.4	-1.7	2.0	0.4	-0.3	-0.0	-0.1
Smoking status: Previous	0.7	1.1	3.8	-0.6	0.1	-1.9	0.5	-0.6	1.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.9	-1.2	0.8	-2.0	-0.4	0.1	1.4	-1.6
Whole body fat-free mass	0.7	3.9	14.0	0.0	1.8	-1.9	-1.0	3.7	1.5	-1.8
Ever had bowel cancer screening	0.7	0.8	2.9	0.6	-0.3	0.5	1.7	-0.9	-0.8	0.6
Medication for cholesterol	0.7	1.0	4.1	1.3	0.3	0.1	-2.0	0.7	-0.8	0.5
Asthma (self-reported)	0.7	1.3	4.9	-0.5	1.5	-0.2	-0.8	2.2	0.7	-0.8
Whole body water mass	0.7	3.8	13.2	0.1	1.8	-2.0	-0.9	3.6	1.6	-1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.6	-0.1	-0.8	1.4	-0.1	-0.1	-1.6	1.1
Medication: Atorvastatin	0.7	0.9	2.6	1.4	0.7	-1.6	-0.3	-0.4	-0.2	0.7
Irritability	0.7	1.2	3.5	-1.9	-0.6	0.8	-1.2	1.1	1.2	-0.3
Impedance of whole body	0.7	3.8	9.9	-2.2	-2.8	1.7	-0.2	-3.1	-0.1	1.0
Arm predicted mass (left)	0.7	3.3	10.9	-0.0	1.6	-2.2	-1.1	3.3	1.4	-1.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	1.6	0.6	-0.6	0.1	-0.1	-0.2	1.5
Breast Cancer	0.6	1.5	5.1	-0.3	0.5	2.1	-0.2	2.3	-0.4	-0.4
Crohns Disease (2012)	0.6	1.0	4.6	-1.2	-0.1	0.0	0.7	0.2	2.1	-0.5
Lupus	0.6	1.0	5.0	-0.3	0.4	1.0	0.4	2.2	-0.5	-0.1
Smoking Status	0.6	1.5	5.8	0.9	1.1	-2.4	1.4	-0.3	0.6	-0.2
Chronotype (morning person)	0.6	1.4	4.2	-0.6	-0.6	2.1	0.4	2.0	0.6	-0.1
Taking other prescription medications	0.6	0.9	3.5	-0.7	0.8	0.2	-1.9	1.3	0.1	0.2
Impedance of arm (right)	0.6	2.9	9.5	-1.5	-2.0	1.5	0.4	-3.1	0.1	1.4
Pulse rate	0.6	1.0	4.2	-0.0	0.8	-0.8	-0.1	2.0	0.9	-0.9
Asthma	0.6	1.3	5.6	-0.4	1.4	0.2	-0.8	2.4	0.4	-0.6
Medication: Lansoprazole	0.6	0.7	2.3	-0.5	0.1	-0.8	-1.1	0.3	1.5	0.7
Impedance of arm (left)	0.6	2.7	7.8	-1.6	-2.2	1.6	0.0	-2.8	0.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.0	1.7	0.9	-0.7	-0.2	0.4	0.6	0.6
Number of full brothers	0.6	0.8	2.5	-0.2	-0.8	-1.3	-1.6	0.1	0.4	0.1
Age at first live birth	0.6	1.0	4.5	-0.2	-2.1	0.8	0.3	-1.1	0.5	-0.8
Alcohol intake frequency.	0.6	1.4	3.7	0.7	1.9	-0.7	-0.2	1.4	0.9	-1.5
Suffer from ‘nerves’	0.6	0.9	2.0	-0.3	0.1	0.8	-1.1	-1.0	-1.4	1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.0	0.6	0.7	1.7	0.4	-0.2	-1.2	0.2
Illnesses of siblings: Diabetes	0.6	0.7	3.2	-0.1	1.0	0.6	0.7	-0.3	-1.8	-0.2
Qualifications: nursing, teaching	0.6	1.0	2.1	-1.4	-0.3	0.0	0.5	1.5	0.8	-1.3
Breast cancer (self-reported)	0.6	0.8	2.6	0.3	-1.6	0.4	1.4	-0.7	0.1	-0.1
Osteoporosis (self-reported)	0.6	0.8	2.3	0.7	-0.8	-1.1	-0.8	-1.5	0.3	0.3
Average weekly champagne plus white wine intake	0.6	0.8	2.7	-0.1	1.0	0.5	1.1	1.6	0.4	-0.7
Wears glasses or contact lenses	0.6	0.7	1.7	0.9	-0.8	1.1	0.3	0.4	-0.8	-1.3
Mother’s age at death	0.6	0.7	2.7	1.2	0.3	-0.7	1.6	-0.3	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	0.4	-0.2	-1.2	-1.1	0.6	1.1	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.8	0.0	-1.3	1.0	-0.9	-0.1	-0.2	1.7
Arm fat-free mass (left)	0.6	3.1	11.1	-0.3	1.2	-2.0	-1.3	3.3	1.4	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	-0.9	-1.1	1.0	-0.5	0.3	1.0	-0.8
Fractured/broken bones in last 5 years	0.6	0.8	1.5	-0.5	-1.1	-1.2	0.7	0.2	0.8	-1.1
Ever depressed for a whole week	0.6	0.7	2.7	-1.1	-1.7	0.2	-0.3	-0.4	0.8	-0.1
Unable to work because of sickness or disability	0.6	0.7	1.5	1.0	1.2	-0.8	-0.9	0.4	-0.6	-0.7
Basal cell carcinoma (self-reported)	0.6	0.8	1.5	-0.2	0.8	0.6	0.9	1.0	-0.9	1.2
Bipolar Disorder (2018)	0.5	0.8	2.5	-1.1	-0.8	-0.0	0.1	0.9	1.6	-0.8
Schizophrenia (2018)	0.5	1.1	3.9	-0.6	-2.0	0.2	-0.4	-1.3	0.1	1.1
Ovarian Cancer	0.5	0.7	2.2	-1.5	0.4	0.0	0.0	1.0	1.0	-0.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.5	0.8	-0.1	0.1	1.0	1.4	0.0	-1.9
Stomach or abdominal pain in last month	0.5	0.6	2.2	0.1	0.3	-0.5	1.5	-1.2	-0.3	-0.3
Supplements: Glucosamine	0.5	0.6	2.3	0.6	0.6	0.4	0.5	1.5	0.1	-1.0
Hearing difficulty/problems with background noise	0.5	0.8	2.9	0.1	0.4	-1.7	0.3	0.8	0.7	-1.2
Trunk fat-free mass	0.5	3.1	12.0	-0.6	1.4	-1.4	-1.0	3.5	1.3	-1.6
Time employed in main current job	0.5	0.6	1.8	-0.9	-0.5	1.3	-1.1	0.2	0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.2	-2.0	-1.1	-0.5	-1.7	1.4	1.1	0.2
Trunk predicted mass	0.5	3.1	11.5	-0.7	1.3	-1.4	-0.9	3.4	1.4	-1.7
Exposure to tobacco smoke at home	0.5	0.6	1.2	-0.3	1.1	-0.6	-0.0	0.9	0.9	-1.0
Tense / ‘highly strung’	0.5	0.9	3.2	-1.8	-1.0	1.1	-0.4	-0.1	0.4	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	-1.3	-0.9	-1.0	-0.2	-1.2	1.8	0.7
Loud music exposure frequency	0.5	0.6	2.2	-0.3	0.6	0.6	0.2	1.5	0.0	-0.9
Gout (self-reported)	0.5	0.7	2.4	-0.8	0.2	-0.5	-1.4	1.5	0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.3	0.3	0.5	1.0	-0.1	0.6	-0.8	1.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	1.0	0.9	-0.4	0.8	-0.6	-0.6	-0.9
Emphysema/chronic bronchitis	0.5	0.6	1.8	0.3	0.6	-1.3	0.7	-0.2	1.3	-0.0
Chest pain or discomfort	0.5	0.8	2.3	-1.4	-1.5	0.6	0.0	-0.1	0.6	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.6	0.9	0.2	-0.8	-1.2	0.0	-0.6	0.5
Knee pain experienced in last month	0.5	0.8	2.4	1.1	-0.3	0.8	-0.0	0.5	-1.5	1.0
Long-standing illness, disability or infirmity	0.5	0.8	1.8	-0.5	-0.4	-0.5	-1.3	1.3	1.1	0.1
Medication: Gliclazide	0.5	0.6	2.7	0.8	0.6	0.3	-0.1	1.6	0.1	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.1	1.2	-0.9	-0.8	1.2	0.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.7	-0.5	-1.4	-0.1	-1.7	1.1	0.3	0.5
Guilty feelings	0.5	0.7	2.2	-0.1	1.2	0.2	0.2	1.5	0.6	-1.0
Alcohol drinker status: Never	0.5	0.6	3.2	0.3	-0.1	1.8	0.4	-0.3	-0.6	0.7
Age started oral contraceptive pill	0.5	0.6	2.3	-0.6	-1.5	0.2	-0.0	-0.4	0.5	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.5	-0.4	-0.1	-1.0	-1.6	0.6	0.7	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	4.1	-1.1	-2.0	0.2	0.0	-0.5	1.1	0.3
Depression (Nagel 2018)	0.4	0.5	1.4	0.2	-0.4	0.9	-0.4	-1.1	-1.2	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.5	0.9	1.2	-0.5	0.4	1.9	1.1	-1.3
Prostate Cancer	0.4	0.6	1.3	1.0	-0.5	0.4	0.9	-0.3	-0.6	-1.1
Schizophrenia (2014)	0.4	0.8	3.4	-0.5	-1.8	0.8	-0.3	-0.6	0.1	1.0
Waist Hip Ratio (WHR)	0.4	1.7	4.0	-0.5	0.2	1.3	1.7	1.7	-0.1	-2.0
Neuroticism	0.4	1.0	3.5	-1.9	-1.3	1.1	-0.8	0.0	0.2	0.4
Number of treatments/medications taken	0.4	0.8	2.6	-0.7	0.3	-1.3	-0.0	0.7	1.6	-0.5
Average weekly spirits intake	0.4	0.4	1.0	-0.5	-1.0	0.5	-0.8	-0.0	0.8	0.6
Sensitivity / hurt feelings	0.4	0.7	1.9	-0.1	1.1	0.2	1.0	0.5	0.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.1	-0.6	0.5	0.6	-0.9	0.0	1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.5	-0.8	-0.4	-1.2	0.1	-0.5	0.7	-0.5
Sitting height	0.4	2.9	13.3	-3.6	-1.5	0.2	-1.8	0.6	1.0	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	0.5	0.4	-0.9	0.6	-1.1	-0.0	-0.8
Number of incorrect matches in round	0.4	0.7	1.3	-0.0	1.0	0.7	-1.1	1.1	-0.8	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.5	0.2	0.0	0.2	-1.9	0.3	-0.5	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	-0.6	-1.2	1.1	-0.0	-0.7	-0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	-0.8	-0.8	0.9	1.0	0.2	1.0	-0.1
Mean time to correctly identify matches	0.4	0.7	1.8	0.3	0.8	1.3	-0.9	0.9	-0.9	-0.5
Number of full sisters	0.4	0.5	1.3	-0.5	0.7	0.3	-1.0	1.2	-0.1	-0.1
Leg pain on walking	0.4	0.5	1.0	1.0	0.6	0.1	1.0	-0.6	-0.8	-0.4
Diabetes diagnosed by doctor	0.4	0.6	2.7	0.9	-0.1	-0.2	1.6	-0.3	-0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	0.4	0.6	-0.8	-0.2	0.1	0.6	-1.1
High cholesterol (Self-reported)	0.4	0.8	2.6	-1.2	-0.1	-0.7	-0.4	-0.2	0.7	-1.6
Average weekly beer plus cider intake	0.4	0.5	2.2	0.2	0.3	0.1	0.8	-0.4	-1.5	0.8
Commuting to job workplace: Cycle	0.4	0.5	0.9	0.9	0.6	0.2	0.9	1.0	0.5	-0.3
Pain experienced in last month	0.4	0.7	1.6	-1.3	-0.1	0.7	-0.4	1.1	0.0	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	0.3	0.9	0.3	-0.4	1.0	-1.0	-0.8
Height	0.3	6.4	22.1	-3.6	-0.4	1.5	-1.7	4.7	0.9	-1.9
Lung FVC	0.3	1.6	4.5	-1.1	-2.0	-0.2	-2.1	-0.4	-0.5	1.1
Hand grip strength (left)	0.3	0.7	3.2	-1.8	-1.0	0.3	0.1	-0.0	0.8	-0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	0.7	0.7	0.2	1.0	-0.5	-0.5	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.0	0.2	1.0	-1.0	1.0	0.1	0.2	-0.8
Medication: Metformin	0.3	0.4	0.9	0.6	-0.5	0.9	0.3	0.3	-0.9	0.5
Average weekly fortified wine intake	0.3	0.3	1.4	0.2	0.4	0.1	-0.3	1.2	0.6	-0.5
Had other major operations	0.3	0.4	1.7	0.5	0.2	-1.3	0.5	0.1	0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.9	1.2	0.4	0.2	-1.4	0.1	-0.3	-0.5
Noisy workplace	0.3	0.4	1.6	-0.4	-0.3	0.4	0.0	-0.8	0.1	1.3
Medication: Cholesterol lowering	0.3	0.4	1.3	-0.9	-1.1	0.3	0.1	-0.7	0.1	0.5
Depression (self-reported)	0.3	0.4	1.4	-0.8	-0.7	1.2	0.0	-0.3	-0.3	0.3
Medication: Paracetamol	0.3	0.5	1.2	0.5	1.0	-1.1	-0.4	0.6	-0.0	-0.7
Comparative body size at age 10	0.3	0.9	1.5	1.0	0.8	-0.1	1.2	1.2	0.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.3	-0.5	0.9	0.7	0.7	0.2	-0.5
Qualifications: College or University degree	0.3	1.1	3.6	-0.0	-1.9	1.2	1.0	-1.0	-0.2	0.5
Migraine (self-reported)	0.3	0.4	1.3	-0.8	-0.3	-0.2	0.1	0.1	0.6	1.1
Medication: Seretide 50 evohaler	0.3	0.3	1.0	-0.4	0.6	0.8	-0.2	1.0	0.3	-0.2
Comparative height size at age 10	0.3	1.9	4.8	-2.2	-1.6	1.9	-0.9	1.2	0.2	-0.3
Overall health rating	0.3	0.5	1.8	-0.5	0.3	-0.9	-1.3	0.6	0.6	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.2	-0.2	0.7	0.9	0.4	0.5	-0.6
Medication: Paracetamol	0.3	0.5	1.0	0.5	0.7	-1.0	-1.0	0.6	0.3	-0.1
Diastolic blood pressure, automated reading	0.3	1.1	1.8	-1.3	-0.9	1.4	-0.7	-1.1	-0.7	1.0
Supplements: Calcium	0.3	0.4	1.0	0.1	-0.4	0.8	0.1	-1.0	-0.3	0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.3	-1.1	-0.7	1.1	-0.1	0.0	-0.3	0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	1.3	0.8	0.2	-1.2	0.1	-0.4	0.0	0.0
Major Depression (MDD)	0.2	0.3	0.6	-0.1	-0.6	0.3	0.6	0.8	0.6	-0.4
Reaction Time	0.2	0.4	1.3	-0.2	0.9	0.1	-0.5	0.4	-0.1	-1.2
Fasting Glucose	0.2	0.3	0.9	0.2	0.2	0.3	-0.8	0.9	-0.3	-0.5
LDL Cholesterol	0.2	0.4	0.9	0.9	0.7	0.0	0.6	-0.4	-0.9	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.8	0.6	-0.8	-0.4	-0.3	0.2	-0.3
Blood Platelet Count	0.2	1.8	4.0	1.7	1.5	-1.8	-2.0	-0.2	-0.3	-0.1
Blood Red Count	0.2	1.8	4.5	1.5	2.1	-1.5	1.2	-0.2	0.6	-1.4
Heel T-Score	0.2	1.5	3.8	1.9	0.5	1.7	0.8	0.4	-1.6	-0.2
Hair Pigment	0.2	4.8	18.9	2.2	4.3	-1.2	0.4	2.1	-1.6	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	-0.5	0.1	-0.4	-1.0	0.4	0.3	0.4
Diabetes (mother)	0.2	0.3	0.7	0.4	0.9	0.2	-0.0	0.8	-0.1	-0.5
Hand grip strength (right)	0.2	0.6	1.8	-0.8	-1.4	-0.1	-0.9	0.5	0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.6	0.5	1.0	0.6	-0.1	1.3	-0.5	-0.8
Illnesses of siblings	0.2	0.2	0.9	0.1	-0.0	1.0	-0.3	0.7	0.0	-0.2
Father’s age at death	0.2	0.2	0.8	-0.8	0.1	-0.2	-0.9	-0.0	0.4	-0.0
Standing height	0.2	2.5	7.5	-2.7	-1.1	0.8	-1.5	2.0	0.9	-1.0
High blood pressure (siblings)	0.2	0.3	1.0	-0.7	-0.5	-0.1	0.1	-1.0	0.2	0.3
Pulse rate, automated reading	0.2	0.8	2.3	0.5	1.1	-0.2	0.2	1.5	0.1	-1.2
Had major operations	0.2	0.3	1.3	1.2	-0.5	-0.4	0.1	0.0	-0.4	0.3
Illnesses of father: Heart disease	0.2	0.3	1.1	1.0	-0.4	-0.4	0.5	-0.4	-0.2	-0.1
Average weekly red wine intake	0.2	0.3	0.5	0.7	-0.3	0.5	-0.7	0.7	-0.3	-0.5
Mood swings	0.2	0.3	0.9	-0.9	0.2	-0.0	-0.9	0.5	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	2.0	0.2	-0.3	-0.1	-0.3	-1.4	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.6	0.0	-0.3	0.5	0.5	0.8	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.8	0.4	0.1	0.5	-0.1	0.9	-0.2	0.0
Blood Eosinophil Count	0.1	1.1	2.5	1.2	1.5	1.0	-0.6	0.1	-1.6	-0.5
Blood White Count	0.1	1.1	6.1	0.6	0.1	-0.3	-2.5	0.6	-0.5	0.5
Tanning	0.1	0.7	1.6	-0.2	0.1	-0.8	-1.2	1.1	0.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.4	0.4	0.3	0.4
Age when periods started (menarche)	0.1	0.2	0.5	0.1	-0.5	0.1	0.7	-0.2	-0.7	0.2
Alcohol usually taken with meals	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.4	-0.1	0.5	0.3
Had menopause	0.1	0.1	0.5	0.1	-0.7	-0.3	-0.1	-0.3	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.4	0.1	0.7	-0.5	-1.2	0.3	0.2	0.0
Fluid intelligence score	0.1	0.1	0.3	0.3	0.4	-0.5	0.3	-0.0	0.3	-0.3
Neuroticism score	0.1	0.3	0.8	-0.8	0.1	0.9	-0.5	0.5	0.2	0.0
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.0	0.4	-0.6	-0.1	0.0	0.3	-0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.4	-0.1	0.2	-0.2	0.1	0.0	0.0
Mineral and other dietary supplements	0.0	0.1	0.2	-0.3	0.4	-0.3	-0.3	-0.1	-0.0	0.2

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