Hub : Genes

SGPL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.129 0.031 7.7e-06 0.077 0.039 0.077 0.064 0.073 1.2e-09 1.5e-05 1.0e-09 2.8e-08 3.3e-09
2 GTEx Esophagus Mucosa 0.306 0.061 2.7e-07 0.134 NA 0.099 NA 0.124 3.1e-09 NA 4.1e-07 NA 1.3e-08
3 GTEx Pancreas 0.565 0.078 1.4e-07 0.525 NA 0.499 NA 0.525 1.3e-25 NA 7.3e-24 NA 1.4e-25
4 GTEx Skin Sun Exposed Lower leg 0.115 0.045 7.6e-03 0.014 NA -0.001 NA 0.011 2.1e-02 NA 4.5e-01 NA 3.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 0.9 -0.5 -0.4 0.8 -0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 1.7 -1.1 0.2 1.3 -0.6
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 0.3 -0.8 -0.4 -0.6
Depression (Nagel 2018) 0.6 0.8 2.1 1.1 0.2 -0.2 1.4
Intelligence (Savage-Jansen 2018) 1.4 4.3 6.2 -0.4 -2.4 -2.5 -2.2
Neuroticism (Nagel 2018) 0.1 0.2 0.5 0.7 -0.0 -0.2 0.6
Schizophrenia (2018) 0.3 0.6 1.0 -1.0 0.6 1.0 -0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 -1.3 0.2 -0.2 -0.3
Worry (Nagel 2018) 0.0 0.1 0.2 0.1 -0.0 0.3 0.5
Alzheimer’s Disease (in mother) 1.4 1.6 2.7 0.6 1.6 1.4 1.2
Alzheimer’s Disease (in father) 0.8 0.8 2.0 1.1 0.2 1.4 -0.2
Alzheimer’s Disease (including proxy) 2.3 3.3 6.1 1.5 1.9 2.5 1.2
Crohns Disease (2017) 0.6 1.3 4.4 -2.1 -0.0 -0.7 0.3
Irritable Bowel Disease (IBD) 0.3 0.6 2.0 -1.4 0.2 -0.7 0.1
Ulcerative Colitis (UC) 0.0 0.1 0.2 0.0 0.5 -0.3 -0.1
Major Depression (MDD) 0.2 0.2 0.6 0.1 -0.4 0.3 -0.8
Reaction Time 0.5 1.0 1.8 -0.5 -1.2 -1.3 -0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.3 -0.5 -1.2 -0.9 -1.5
Breast Cancer 0.2 0.5 1.4 1.2 -0.4 -0.5 0.1
Ovarian Cancer 0.5 0.6 1.5 1.2 0.3 1.0 0.0
Prostate Cancer 0.6 0.8 1.5 1.2 0.5 1.0 -0.8
Age at First Birth 0.3 0.5 1.8 0.3 -0.1 1.3 -0.2
Bipolar Disorder (2011) 0.9 0.9 2.9 0.5 -0.3 1.7 -0.5
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 0.7 0.4 0.4 0.9
Coronary Artery Disease (CAD) 1.8 2.1 5.4 0.9 1.5 0.3 2.3
Crohns Disease (2012) 0.8 1.3 3.3 -1.0 -1.0 -1.8 -0.1
Mean Putamen Volume 0.1 0.1 0.2 0.1 0.4 0.3 0.4
Fasting Glucose 0.7 0.8 1.4 0.5 1.2 0.3 1.2
HbA1C 0.5 0.5 1.1 -0.3 -0.9 0.2 -1.1
HDL Cholesterol 0.1 0.2 0.4 0.3 0.5 -0.6 0.2
LDL Cholesterol 0.8 1.3 2.3 -0.1 1.4 0.9 1.5
Lupus 1.1 1.7 4.6 0.3 -1.2 -2.1 0.8
Neuroticism (2016) 0.2 0.3 0.9 -0.1 -0.9 -0.1 0.6
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.3 0.4 -0.2 -0.5
Rheumatoid Arthritis 0.3 0.3 1.4 0.1 0.1 1.2 -0.1
Schizophrenia (2014) 0.3 0.6 0.8 -0.9 0.9 0.9 0.4
Triglycerides 0.9 1.5 3.3 1.8 1.0 -0.3 1.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.2 -0.5 0.6 -0.0 -1.1
Ulcerative Colitis 0.1 0.1 0.2 -0.3 0.1 0.4 0.2
Blood Eosinophil Count 0.0 0.1 0.2 -0.3 0.1 -0.4 -0.1
Blood Platelet Count 0.2 1.8 6.2 2.5 0.8 0.6 0.2
Blood Red Count 0.4 4.0 11.8 -3.4 1.1 1.6 0.7
Blood White Count 0.4 3.3 6.5 -0.5 1.2 2.5 2.2
Heel T-Score 0.2 1.9 3.6 -1.9 1.4 -1.2 -0.6
BMI 0.2 1.0 2.2 -1.5 0.6 1.2 0.5
Height 0.1 1.4 1.8 -1.4 -1.2 -0.9 -1.2
Waist Hip Ratio (WHR) 0.5 2.1 4.0 -2.0 -0.4 -0.5 -2.0
Systolic Blood Pressure 0.1 0.7 2.6 0.0 0.1 -1.6 0.5
Smoking Status 0.2 0.4 1.3 -0.0 0.1 -1.2 0.6
Allergy or Eczema 0.6 1.6 3.5 -1.9 -0.0 -1.4 1.0
Cardiovascular Disease 0.4 1.4 2.0 1.3 1.1 -0.8 1.4
Hypothyroidism (self reported) 0.2 0.4 1.2 0.3 0.4 -1.1 0.2
Respiratory disease 0.1 0.1 0.4 0.0 0.4 0.6 0.1
Type 2 Diabetes (T2D) (2018) 2.7 5.1 8.1 -0.9 -2.1 -2.9 -2.6
Lung FEV1/FVC ratio 0.3 1.6 2.6 -1.1 -1.6 -1.6 0.4
Lung FVC 0.1 0.5 1.3 0.4 1.1 -0.4 0.4
Neuroticism 0.1 0.2 0.4 0.4 -0.6 -0.6 0.3
Chronotype (morning person) 0.3 0.6 1.3 -0.4 -0.5 0.8 -1.1
Hair Pigment 0.0 0.4 1.1 0.6 -0.2 -1.1 0.4
Tanning 0.2 2.5 7.3 0.6 1.5 2.7 0.3
Hand grip strength (left) 0.1 0.3 0.5 -0.7 0.3 0.7 0.0
Number of treatments/medications taken 0.3 0.6 1.2 0.6 -0.3 -0.7 1.1
Average weekly spirits intake 1.0 1.2 2.6 -1.6 0.2 1.5 0.0
Sensitivity / hurt feelings 0.5 0.9 1.6 0.2 0.7 1.3 1.3
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 0.6 -0.0 -0.2 0.8
Hearing difficulty/problems: Yes 0.6 0.9 2.4 1.5 -0.1 -1.0 0.5
Relative age of first facial hair 0.9 1.8 4.4 2.1 0.9 -0.7 1.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.9 -0.7 -0.7 -0.9 -0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.6 -0.3 -0.9 0.6
Ever had hysterectomy (womb removed) 1.5 1.7 5.3 0.6 0.0 -2.3 1.0
Systolic blood pressure, automated reading 0.3 0.9 1.9 -1.4 -0.6 -1.2 -0.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.7 -0.7 -1.1 -1.6 0.4
Angina 0.5 0.6 1.4 -0.9 -1.2 0.2 -0.6
Medication for hormone replacement therapy 0.5 0.5 1.9 0.1 0.0 1.4 -0.5
Vitamin and mineral supplements 0.3 0.4 0.8 0.9 0.1 -0.2 0.9
Supplements: Zinc 0.4 0.4 1.0 -0.5 -0.5 -1.0 -0.2
Medication: Co-codamol 0.5 0.5 1.0 -0.6 -0.8 -1.0 0.4
Medication: Metformin 2.0 2.9 6.4 -1.2 -1.9 -2.5 -0.5
Diabetes (father) 1.4 1.8 3.6 0.2 -0.9 -1.6 -1.9
Diabetes (mother) 0.5 0.6 1.1 -0.7 0.9 -0.1 1.1
Severe depression (siblings) 3.2 3.5 8.0 2.8 1.8 0.1 1.7
Pack years adult smoking proportion 0.2 0.3 0.8 -0.5 0.5 0.9 0.1
Impedance of leg (right) 0.5 2.5 9.9 -3.1 -0.3 -0.0 -0.1
Leg fat-free mass (left) 0.0 0.1 0.3 0.0 -0.1 0.6 -0.5
Trunk fat percentage 1.8 7.1 25.3 -5.0 0.0 1.7 -0.4
Hand grip strength (right) 0.1 0.3 1.1 -0.2 0.5 1.0 0.1
Townsend deprivation index at recruitment 0.7 1.0 3.0 0.7 -0.7 -1.7 0.3
Current tobacco smoking 0.0 0.0 0.1 -0.2 0.1 -0.3 0.2
Average weekly fortified wine intake 0.8 1.0 2.9 -1.7 -0.6 0.8 -0.0
Maternal smoking around birth 0.3 0.5 1.0 0.7 0.5 0.2 1.0
Fed-up feelings 0.4 0.6 1.8 1.4 0.2 -0.3 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 2.9 6.7 2.6 0.9 -0.4 2.0
Relative age voice broke 1.3 2.1 3.2 1.4 1.8 0.5 1.7
Taking other prescription medications 0.2 0.3 1.0 -0.4 -0.2 -1.0 0.3
Age when periods started (menarche) 1.1 2.7 4.4 1.5 1.2 1.6 2.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.6 0.0 -0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 0.1 -0.8 -1.0 -0.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 -0.5 0.1 0.6 0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.3 -1.1 -0.7 0.2 -0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.5 -0.1 -0.1 -1.2 -0.1
High blood pressure 1.2 3.3 5.1 2.2 1.7 -0.6 2.2
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.9 -1.7 0.6 -0.8 0.8
Multivitamins +/- minerals 0.6 0.7 2.3 -0.6 -0.5 0.1 -1.5
Stomach or abdominal pain in last month 0.5 0.7 1.2 0.3 -0.7 -1.1 1.0
Supplements: Glucosamine 2.2 2.9 7.2 2.7 1.2 1.0 1.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.9 -1.4 0.2 0.4 0.0
Medication: Atenolol 0.3 0.4 0.5 -0.6 -0.6 -0.7 0.5
Medication: Levothyroxine sodium 0.5 0.9 2.6 0.7 -0.4 -1.6 -0.5
Sitting height 0.0 0.2 0.4 0.2 -0.6 -0.6 0.1
Chronic bronchitis/emphysema (father) 3.0 3.5 5.6 1.6 2.2 2.4 1.0
High blood pressure (mother) 1.6 2.3 5.2 1.5 1.2 -0.6 2.3
Body mass index (BMI) 0.3 1.3 4.4 -2.1 -0.6 0.7 -0.2
Impedance of leg (left) 0.6 3.1 11.6 -3.4 0.5 0.8 -0.2
Leg predicted mass (left) 0.0 0.1 0.3 -0.1 -0.2 0.5 -0.5
Trunk fat mass 1.2 5.1 18.1 -4.2 -0.5 1.3 -0.5
Waist circumference 0.7 2.5 8.7 -3.0 -0.3 0.9 -0.5
Number of incorrect matches in round 0.2 0.3 0.5 0.3 -0.5 0.6 0.7
Past tobacco smoking 0.2 0.4 1.6 -0.1 0.2 1.2 -0.3
Alcohol usually taken with meals 0.3 0.5 0.9 0.7 -0.9 -0.2 -0.7
Nervous feelings 0.0 0.1 0.2 -0.5 -0.1 0.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 3.8 0.8 1.9 1.4 1.5
Hearing difficulty/problems with background noise 0.2 0.4 0.9 1.0 0.2 0.3 0.6
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 -0.4 0.3 -0.6 0.7
Had menopause 0.0 0.0 0.1 0.3 -0.1 0.1 -0.1
Had other major operations 0.3 0.4 0.8 0.9 -0.3 0.3 -0.7
Forced vital capacity (FVC) 0.0 0.2 0.5 0.3 0.3 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.5 0.7 0.6 0.6 0.6
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 -0.1 0.1 -0.3 0.1
Qualifications: None of the above 1.0 2.1 3.3 0.5 1.8 1.5 1.6
Financial difficulties in last 2 years 0.7 1.0 2.2 1.5 -0.1 -1.3 0.4
Mouth/teeth dental problems 0.2 0.3 0.7 -0.4 0.5 0.2 -0.9
Heart attack 1.9 2.4 8.7 -0.1 0.9 0.5 2.9
Allergy 0.3 0.7 1.4 0.7 -1.2 0.2 -1.0
Pain all over the body in last month 0.7 0.8 1.9 -1.4 -0.1 0.1 1.1
Diabetes (self-reported) 3.1 4.8 8.1 -1.6 -2.4 -2.8 -1.8
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 3.7 1.9 0.9 -0.6 0.7
Medication: Ramipril 1.2 1.5 2.5 -1.6 1.5 1.1 0.3
Medication: Simvastatin 0.3 0.4 0.9 -0.3 -0.7 -0.9 -0.3
Fluid intelligence score 0.3 0.5 1.0 0.1 -0.6 -0.9 -1.0
Illnesses of siblings 0.7 1.0 1.8 -0.2 0.5 1.3 -1.3
Neuroticism score 0.1 0.3 0.3 0.5 -0.5 -0.5 0.6
Weight 0.3 1.5 5.6 -2.4 -0.5 0.6 -0.2
Impedance of arm (right) 0.4 1.6 5.3 -2.3 0.6 -0.3 -0.9
Arm fat percentage (right) 1.0 3.9 13.1 -3.6 -0.8 0.7 -1.1
Trunk fat-free mass 0.2 1.2 2.8 0.7 -1.7 -0.9 -0.9
Hip circumference 0.4 1.9 4.8 -2.2 0.3 1.5 0.7
Time employed in main current job 1.0 1.1 3.7 1.9 0.3 0.9 -0.0
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.8 -0.6 -0.1 0.3
Father’s age at death 0.1 0.2 0.4 0.1 0.3 -0.7 -0.4
Worrier / anxious feelings 0.2 0.3 0.7 0.2 -0.7 -0.2 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.8 0.7 -0.3 -0.2 0.9
Falls in the last year 0.3 0.4 1.3 -1.1 -0.4 0.3 0.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.4 -0.2 -0.9 0.3
Number of live births 0.2 0.3 0.6 -0.2 0.5 0.7 0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.8 0.1 0.3 0.1 -0.9
Pulse rate 0.4 0.6 2.2 -1.5 -0.2 0.4 0.4
Happiness 0.1 0.1 0.3 -0.2 -0.3 -0.2 -0.5
Noisy workplace 2.5 3.1 8.4 -0.1 1.4 1.4 2.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 3.1 0.1 -1.3 -1.8 -1.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.3 -0.6 0.4 -0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 -0.1 -0.4 -0.4 0.8
Asthma 0.0 0.1 0.2 0.1 0.4 0.1 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.0 0.8 2.0 0.9 0.1
Medication: Cholesterol lowering 1.1 1.7 2.7 -1.3 -1.6 -1.1 -1.1
Depression (self-reported) 0.6 0.7 1.6 -0.4 -1.1 -1.3 -0.1
Medication: Lansoprazole 0.4 0.5 0.9 1.0 -0.8 -0.6 -0.0
Prospective memory result 0.9 1.1 2.4 -0.1 -1.0 -1.5 1.0
Lung cancer (father) 3.3 3.8 6.2 0.5 1.9 2.3 2.5
Illnesses of mother 0.5 0.6 1.9 -1.4 -0.3 0.2 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.2 -0.6 -0.7 -0.6 -2.0
Pulse wave Arterial Stiffness index 0.7 0.8 2.4 -0.4 0.4 0.8 1.6
Impedance of arm (left) 0.3 1.2 3.5 -1.9 1.1 -0.2 -0.6
Arm fat mass (right) 0.8 3.1 10.2 -3.2 -1.0 0.6 -0.9
Trunk predicted mass 0.2 1.3 3.1 0.7 -1.8 -0.9 -1.0
Standing height 0.0 0.3 0.7 -0.9 -0.2 -0.3 -0.6
Length of working week for main job 1.0 1.1 2.6 -0.2 1.6 0.8 1.1
Exposure to tobacco smoke at home 0.7 0.8 1.8 0.4 1.1 -0.0 1.4
Breastfed as a baby 0.1 0.1 0.3 0.4 0.5 0.3 0.1
Tense / ‘highly strung’ 0.0 0.0 0.0 -0.0 0.1 -0.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.0 -0.5 -0.6 -1.0 -0.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.4 0.6 0.5 0.7 -0.1
Birth weight of first child 1.4 2.6 4.3 -0.9 -2.0 -1.1 -2.1
Peak expiratory flow (PEF) 0.2 0.4 0.9 1.0 0.8 0.3 0.4
Pulse wave reflection index 0.1 0.1 0.4 0.2 -0.0 0.6 -0.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.5 0.8 1.6 -0.5 0.1
Loud music exposure frequency 0.8 0.8 1.3 0.8 -1.2 -1.0 -0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.4 -0.3 -0.7 -1.6 -0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 0.9 -1.0 -0.7 -0.6 0.8
Blood clot in the leg (DVT) 0.7 0.9 1.7 1.3 0.1 -0.4 -1.3
Medication: Paracetamol 1.0 1.7 5.0 -0.0 0.9 2.2 1.1
Headache pain in last month 1.3 2.2 3.9 1.4 1.5 0.8 2.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.3 -0.2 0.8 1.1 0.3
Glaucoma (self-reported) 0.1 0.1 0.2 0.1 -0.3 -0.0 0.5
Gout (self-reported) 0.9 1.3 2.9 0.8 0.1 -1.7 1.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.1 -0.5 -0.3 -1.0 -0.7
Medication: Amlodipine 0.5 0.6 1.8 1.4 -0.5 0.6 -0.0
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.9 0.2 -1.1 -0.2 -1.7
Birth weight 0.3 0.5 1.7 -0.7 -0.2 0.1 -1.3
Chronic bronchitis/emphysema (mother) 1.2 1.4 3.1 -1.1 -1.1 -0.1 -1.8
High blood pressure (siblings) 0.2 0.2 0.5 -0.4 -0.3 -0.7 0.4
Forced vital capacity (FVC), Best measure 0.4 1.6 5.2 -0.6 -0.8 -0.6 -2.3
Body fat percentage 1.8 7.0 25.4 -5.0 -0.3 1.6 -0.2
Leg fat percentage (right) 2.0 7.2 25.6 -5.1 -1.3 1.2 -0.1
Arm fat-free mass (right) 0.1 0.6 1.0 -0.6 -1.0 0.7 -0.7
Exposure to tobacco smoke outside home 0.2 0.2 0.5 0.5 -0.7 -0.1 -0.5
Comparative body size at age 10 0.3 0.7 2.0 -1.4 -0.1 0.9 -0.3
Number of full brothers 1.3 1.6 2.5 1.6 0.2 -1.1 1.6
Worry too long after embarrassment 2.5 4.2 8.8 3.0 1.6 1.4 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.1 0.3 -0.4 0.1
Wheeze or whistling in the chest in last year 0.3 0.6 1.3 0.7 0.2 -0.7 -1.1
Number of children fathered 1.0 1.1 2.3 0.9 1.5 0.6 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.5 0.4 0.4 1.2 -0.1
Age at first live birth 0.1 0.2 0.4 0.6 0.4 0.4 0.0
Pulse wave peak to peak time 0.8 0.9 2.7 0.4 -0.3 -0.8 -1.6
Health satisfaction 0.2 0.2 0.6 -0.8 -0.1 0.1 -0.5
Shortness of breath walking on level ground 0.6 0.7 1.1 -0.4 1.1 0.8 0.9
Qualifications: College or University degree 1.1 3.6 11.1 -0.7 -1.2 -1.1 -3.3
Eye problems/disorders: None of the above 3.1 3.5 6.5 1.6 2.3 2.6 -0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 3.4 -0.4 0.1 -0.2 1.8
Emphysema/chronic bronchitis 0.2 0.2 0.6 0.4 0.8 0.1 0.5
Medication for pain relief, constipation, heartburn 0.3 0.5 2.0 0.4 0.1 -1.4 -0.2
Neck or shoulder pain in last month 1.1 1.5 4.8 2.2 0.8 0.6 0.5
Medication: Blood pressure 0.3 0.6 1.3 0.7 -0.6 -1.2 0.2
Angina (self-reported) 0.3 0.4 0.7 -0.7 -0.9 0.4 -0.1
Migraine (self-reported) 0.7 0.8 2.4 -0.9 1.6 -0.0 0.2
Medication: Ibuprofen 0.6 0.7 1.8 0.8 1.3 0.7 -0.0
Medication: Allopurinol 1.5 2.0 5.6 0.2 -1.4 -2.4 -0.7
Medication: Omeprazole 0.5 0.6 1.3 -1.1 -0.8 0.5 -0.5
Medication: Seretide 50 evohaler 0.2 0.2 0.8 0.1 0.1 -0.1 -0.9
Mean time to correctly identify matches 0.3 0.6 1.1 -0.7 -1.1 -0.8 -0.5
Heart disease (mother) 1.0 1.3 4.1 0.3 -1.0 -2.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.6 1.2 0.2 -0.7 0.4
Whole body fat mass 1.2 4.9 17.3 -4.2 -0.6 1.3 -0.5
Leg fat mass (right) 1.2 4.5 15.1 -3.9 -0.7 1.5 -0.1
Arm predicted mass (right) 0.1 0.4 0.8 -0.3 -0.9 0.6 -0.3
Pulse rate, automated reading 0.1 0.3 0.7 -0.8 -0.6 0.1 -0.2
Alcohol intake frequency. 0.5 1.1 3.8 -1.9 -0.7 -0.3 0.1
Comparative height size at age 10 0.6 3.1 10.2 -3.2 -0.6 -0.0 -1.4
Number of full sisters 2.7 3.3 6.9 2.1 1.5 -0.2 2.6
Suffer from ‘nerves’ 0.7 1.1 3.6 0.2 -0.3 -0.7 1.9
Overall health rating 0.3 0.7 2.6 -0.4 0.3 -0.2 1.6
Chest pain or discomfort 0.3 0.4 1.1 1.1 0.1 0.4 0.7
Had major operations 0.5 0.6 2.1 1.4 -0.3 -0.4 0.0
Age at last live birth 0.9 1.3 5.0 0.2 -0.2 0.2 -2.2
Family relationship satisfaction 2.2 2.7 5.9 -0.1 -1.9 -1.1 -2.4
Leg pain on walking 0.1 0.1 0.2 -0.2 0.4 -0.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 -0.0 -0.3 -0.8 1.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 5.4 1.0 1.1 2.3 0.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -0.1 0.6 0.3 -1.0
Medication: Aspirin 0.1 0.2 0.5 -0.3 -0.7 0.3 0.0
Supplements: Vitamin C 1.2 1.4 3.0 -1.7 -0.5 -0.9 -1.3
Knee pain experienced in last month 0.1 0.2 0.5 -0.7 0.0 0.4 0.1
Hypertension (Self-reported) 1.1 3.1 5.2 1.9 1.8 -0.6 2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 0.3 -0.1 -0.6 0.4
Illnesses of father: Heart disease 0.4 0.6 0.9 -0.9 0.8 0.5 0.8
Illnesses of siblings: Diabetes 1.0 1.3 3.3 0.8 0.8 -0.7 1.8
Smoking status: Previous 0.2 0.3 0.5 0.5 0.2 -0.7 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.2 -0.6 -1.1 -0.9 -0.7
Whole body fat-free mass 0.1 0.3 0.8 0.3 -0.9 -0.1 -0.7
Leg fat-free mass (right) 0.0 0.2 0.5 0.4 0.3 0.7 -0.4
Arm fat percentage (left) 0.9 3.6 12.7 -3.6 -0.6 1.0 -0.7
Average weekly red wine intake 0.9 1.3 2.0 0.2 -1.4 -1.4 -1.1
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.6 0.7 -0.1 -0.8 -0.1
Mood swings 0.4 0.7 1.6 0.7 -0.5 -1.3 -0.5
Loneliness, isolation 1.5 2.1 5.2 -1.2 -1.2 0.2 -2.3
Long-standing illness, disability or infirmity 0.2 0.2 0.6 -0.8 -0.2 -0.6 -0.1
Ever had bowel cancer screening 0.2 0.2 0.6 -0.8 0.4 0.3 0.1
Diabetes diagnosed by doctor 2.7 4.4 8.1 -1.4 -2.2 -2.9 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.9 -1.4 0.3 -0.0 -0.1
Friendships satisfaction 0.8 1.0 2.5 -0.4 -0.6 -1.0 -1.6
Qualifications: nursing, teaching 0.3 0.5 1.0 1.0 -0.2 -0.8 0.5
Commuting to job workplace: Walk 0.6 0.6 1.4 0.2 -0.9 -1.2 -0.6
Eye problems/disorders: Cataract 1.3 1.5 4.6 -0.8 -2.1 -0.8 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.2 1.5 0.7 0.5 0.1
Medication for cholesterol 0.7 1.1 2.9 -0.4 -1.2 -1.7 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 3.5 0.1 -1.9 -0.8 -0.4
Back pain experienced in last month 1.0 1.5 3.5 1.1 1.2 -0.1 1.9
Mineral and other dietary supplements 0.2 0.2 0.8 -0.9 -0.3 0.2 -0.1
Breast cancer (self-reported) 1.0 1.2 3.2 1.8 -0.8 -0.6 -0.9
Asthma (self-reported) 0.0 0.1 0.2 0.3 0.4 -0.0 -0.3
Osteoporosis (self-reported) 0.2 0.2 0.4 0.7 0.6 -0.1 -0.1
Osteoarthritis (self-reported) 0.4 0.5 1.3 1.1 -0.4 -0.5 -0.5
Medication: Aspirin 0.3 0.4 1.6 -0.3 -1.2 -0.1 -0.3
Medication: Gliclazide 1.4 1.6 2.5 -1.6 -1.3 -0.3 -1.5
Illnesses of father: None of the above (group 1) 1.2 1.5 4.1 0.6 -0.9 -2.0 0.7
Smoking status: Current 0.0 0.1 0.2 -0.3 -0.1 -0.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.7 0.3 1.3 0.6 0.1
Whole body water mass 0.1 0.4 0.9 0.3 -0.9 -0.1 -0.7
Leg predicted mass (right) 0.0 0.2 0.4 0.4 0.3 0.6 -0.4
Arm fat mass (left) 0.8 3.2 10.8 -3.3 -1.0 0.5 -1.0
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 1.0 0.7 -0.5 0.5
Average weekly champagne plus white wine intake 1.4 1.9 4.1 1.2 -1.4 -2.0 -0.3
Miserableness 0.3 0.6 1.2 1.0 0.2 -0.2 1.1
Guilty feelings 0.6 1.0 2.6 1.0 0.5 0.3 1.6
Wears glasses or contact lenses 0.2 0.2 0.8 -0.1 -0.0 -0.2 0.9
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.1 0.4 -0.2 0.1
Hearing aid user 0.8 0.9 2.4 -0.9 -0.5 0.4 -1.6
Mother’s age at death 0.4 0.5 0.8 -0.8 -0.6 -0.3 -0.9
Financial situation satisfaction 0.4 0.5 0.8 0.1 -0.7 -0.9 -0.9
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 -0.7 0.0 -0.2 -0.6
Commuting to job workplace: Public transport 0.9 1.1 2.9 1.1 -0.3 -1.7 -0.4
Eye problems/disorders: Glaucoma 0.3 0.4 1.3 0.0 0.3 0.1 1.2
Medication: Blood pressure 0.2 0.4 1.1 0.1 1.1 0.4 0.6
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.7 0.2 1.3 1.1 1.2
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.8 0.9 -0.4 -1.4 0.7
High cholesterol (Self-reported) 0.3 0.6 1.1 -0.8 -0.3 1.1 -0.7
Medication: Bendroflumethiazide 1.8 2.8 5.5 -0.6 -2.3 -1.9 -1.3
Medication: Paracetamol 1.0 1.6 4.2 -0.2 0.7 2.0 1.2
Medication: Lisinopril 3.2 4.2 9.6 -0.7 -2.5 -3.1 -0.2
Medication: Atorvastatin 0.8 1.0 2.4 -0.7 -0.9 -0.4 -1.6
Illnesses of father: High blood pressure 1.7 2.1 6.0 -0.0 -1.4 -0.6 -2.4
Alcohol drinker status: Never 0.4 0.4 1.0 -1.0 -0.2 -0.8 -0.3
Ever smoked 0.9 1.5 4.4 0.1 -1.2 -2.1 0.4
Basal metabolic rate 0.1 0.3 0.7 -0.5 -0.8 0.0 -0.6
Leg fat percentage (left) 2.1 7.5 26.6 -5.2 -0.9 1.6 -0.2
Arm fat-free mass (left) 0.1 0.7 1.3 -1.0 -1.1 0.3 -0.7
Number of operations (self-reported) 0.8 1.2 2.7 1.6 -0.9 0.3 -1.1
Average weekly beer plus cider intake 0.8 1.1 2.8 1.7 0.6 1.0 0.6
Irritability 0.2 0.3 0.5 -0.7 0.7 0.3 -0.2
Risk taking 0.2 0.2 0.5 0.3 -0.1 0.7 -0.6
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.4 1.6 0.9 0.8 1.1
Fractured/broken bones in last 5 years 0.3 0.4 1.3 1.2 -0.2 -0.5 -0.0
Age started oral contraceptive pill 0.8 1.1 2.1 -1.4 0.9 0.9 0.6
Diastolic blood pressure, automated reading 0.2 0.5 1.3 -0.8 0.3 0.5 1.1
Ever depressed for a whole week 0.3 0.4 1.3 0.1 1.1 -0.0 0.4
Unable to work because of sickness or disability 0.3 0.3 0.6 0.5 0.2 -0.7 0.8
Commuting to job workplace: Cycle 0.5 0.6 2.1 -0.2 -0.5 -1.5 -0.3
Myopia 1.6 2.3 5.1 2.2 -0.0 -0.4 -2.0
Vascular/heart problems diagnosed by doctor 1.1 3.0 4.7 -2.0 -1.7 0.2 -2.2
Cholesterol lowering medication 0.3 0.4 1.6 -0.2 -0.2 0.3 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 -1.1 -1.0 -0.1 -0.4
Pain experienced in last month 0.7 1.1 1.3 -1.1 -0.9 -1.1 -1.2
Supplements: Calcium 4.2 4.7 10.0 1.6 2.3 1.0 3.2
Basal cell carcinoma (self-reported) 0.6 0.7 2.1 -0.6 -0.4 0.2 -1.4
Heart attack/myocardial infarction (self-reported) 1.7 2.2 7.9 -0.0 0.9 0.3 2.8
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.2 1.1 0.2 -0.3 -1.1
Heart disease (siblings) 1.1 1.3 3.2 0.1 -1.0 -1.8 1.1
Alcohol drinker status: Previous 1.0 1.2 3.9 0.2 0.8 0.1 2.0
Pack years of smoking 0.2 0.3 0.5 -0.6 0.4 0.7 -0.0
Impedance of whole body 0.5 2.7 10.0 -3.2 0.8 0.4 -0.3
Leg fat mass (left) 1.2 4.7 15.7 -4.0 -0.4 1.7 -0.1
Arm predicted mass (left) 0.1 0.6 1.0 -1.0 -0.8 0.5 -0.6