Hub : Genes

SGPL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.129	0.031	7.7e-06	0.077	0.039	0.077	0.064	0.073	1.2e-09	1.5e-05	1.0e-09	2.8e-08	3.3e-09
2	GTEx	Esophagus Mucosa	0.306	0.061	2.7e-07	0.134	NA	0.099	NA	0.124	3.1e-09	NA	4.1e-07	NA	1.3e-08
3	GTEx	Pancreas	0.565	0.078	1.4e-07	0.525	NA	0.499	NA	0.525	1.3e-25	NA	7.3e-24	NA	1.4e-25
4	GTEx	Skin Sun Exposed Lower leg	0.115	0.045	7.6e-03	0.014	NA	-0.001	NA	0.011	2.1e-02	NA	4.5e-01	NA	3.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.5	-0.4	0.8	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	-1.1	0.2	1.3	-0.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	0.3	-0.8	-0.4	-0.6
Depression (Nagel 2018)	0.6	0.8	2.1	1.1	0.2	-0.2	1.4
Intelligence (Savage-Jansen 2018)	1.4	4.3	6.2	-0.4	-2.4	-2.5	-2.2
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.7	-0.0	-0.2	0.6
Schizophrenia (2018)	0.3	0.6	1.0	-1.0	0.6	1.0	-0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	-1.3	0.2	-0.2	-0.3
Worry (Nagel 2018)	0.0	0.1	0.2	0.1	-0.0	0.3	0.5
Alzheimer’s Disease (in mother)	1.4	1.6	2.7	0.6	1.6	1.4	1.2
Alzheimer’s Disease (in father)	0.8	0.8	2.0	1.1	0.2	1.4	-0.2
Alzheimer’s Disease (including proxy)	2.3	3.3	6.1	1.5	1.9	2.5	1.2
Crohns Disease (2017)	0.6	1.3	4.4	-2.1	-0.0	-0.7	0.3
Irritable Bowel Disease (IBD)	0.3	0.6	2.0	-1.4	0.2	-0.7	0.1
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.0	0.5	-0.3	-0.1
Major Depression (MDD)	0.2	0.2	0.6	0.1	-0.4	0.3	-0.8
Reaction Time	0.5	1.0	1.8	-0.5	-1.2	-1.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	-0.5	-1.2	-0.9	-1.5
Breast Cancer	0.2	0.5	1.4	1.2	-0.4	-0.5	0.1
Ovarian Cancer	0.5	0.6	1.5	1.2	0.3	1.0	0.0
Prostate Cancer	0.6	0.8	1.5	1.2	0.5	1.0	-0.8
Age at First Birth	0.3	0.5	1.8	0.3	-0.1	1.3	-0.2
Bipolar Disorder (2011)	0.9	0.9	2.9	0.5	-0.3	1.7	-0.5
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.7	0.4	0.4	0.9
Coronary Artery Disease (CAD)	1.8	2.1	5.4	0.9	1.5	0.3	2.3
Crohns Disease (2012)	0.8	1.3	3.3	-1.0	-1.0	-1.8	-0.1
Mean Putamen Volume	0.1	0.1	0.2	0.1	0.4	0.3	0.4
Fasting Glucose	0.7	0.8	1.4	0.5	1.2	0.3	1.2
HbA1C	0.5	0.5	1.1	-0.3	-0.9	0.2	-1.1
HDL Cholesterol	0.1	0.2	0.4	0.3	0.5	-0.6	0.2
LDL Cholesterol	0.8	1.3	2.3	-0.1	1.4	0.9	1.5
Lupus	1.1	1.7	4.6	0.3	-1.2	-2.1	0.8
Neuroticism (2016)	0.2	0.3	0.9	-0.1	-0.9	-0.1	0.6
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	0.4	-0.2	-0.5
Rheumatoid Arthritis	0.3	0.3	1.4	0.1	0.1	1.2	-0.1
Schizophrenia (2014)	0.3	0.6	0.8	-0.9	0.9	0.9	0.4
Triglycerides	0.9	1.5	3.3	1.8	1.0	-0.3	1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.5	0.6	-0.0	-1.1
Ulcerative Colitis	0.1	0.1	0.2	-0.3	0.1	0.4	0.2
Blood Eosinophil Count	0.0	0.1	0.2	-0.3	0.1	-0.4	-0.1
Blood Platelet Count	0.2	1.8	6.2	2.5	0.8	0.6	0.2
Blood Red Count	0.4	4.0	11.8	-3.4	1.1	1.6	0.7
Blood White Count	0.4	3.3	6.5	-0.5	1.2	2.5	2.2
Heel T-Score	0.2	1.9	3.6	-1.9	1.4	-1.2	-0.6
BMI	0.2	1.0	2.2	-1.5	0.6	1.2	0.5
Height	0.1	1.4	1.8	-1.4	-1.2	-0.9	-1.2
Waist Hip Ratio (WHR)	0.5	2.1	4.0	-2.0	-0.4	-0.5	-2.0
Systolic Blood Pressure	0.1	0.7	2.6	0.0	0.1	-1.6	0.5
Smoking Status	0.2	0.4	1.3	-0.0	0.1	-1.2	0.6
Allergy or Eczema	0.6	1.6	3.5	-1.9	-0.0	-1.4	1.0
Cardiovascular Disease	0.4	1.4	2.0	1.3	1.1	-0.8	1.4
Hypothyroidism (self reported)	0.2	0.4	1.2	0.3	0.4	-1.1	0.2
Respiratory disease	0.1	0.1	0.4	0.0	0.4	0.6	0.1
Type 2 Diabetes (T2D) (2018)	2.7	5.1	8.1	-0.9	-2.1	-2.9	-2.6
Lung FEV1/FVC ratio	0.3	1.6	2.6	-1.1	-1.6	-1.6	0.4
Lung FVC	0.1	0.5	1.3	0.4	1.1	-0.4	0.4
Neuroticism	0.1	0.2	0.4	0.4	-0.6	-0.6	0.3
Chronotype (morning person)	0.3	0.6	1.3	-0.4	-0.5	0.8	-1.1
Hair Pigment	0.0	0.4	1.1	0.6	-0.2	-1.1	0.4
Tanning	0.2	2.5	7.3	0.6	1.5	2.7	0.3
Hand grip strength (left)	0.1	0.3	0.5	-0.7	0.3	0.7	0.0
Number of treatments/medications taken	0.3	0.6	1.2	0.6	-0.3	-0.7	1.1
Average weekly spirits intake	1.0	1.2	2.6	-1.6	0.2	1.5	0.0
Sensitivity / hurt feelings	0.5	0.9	1.6	0.2	0.7	1.3	1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.6	-0.0	-0.2	0.8
Hearing difficulty/problems: Yes	0.6	0.9	2.4	1.5	-0.1	-1.0	0.5
Relative age of first facial hair	0.9	1.8	4.4	2.1	0.9	-0.7	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.7	-0.7	-0.9	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.6	-0.3	-0.9	0.6
Ever had hysterectomy (womb removed)	1.5	1.7	5.3	0.6	0.0	-2.3	1.0
Systolic blood pressure, automated reading	0.3	0.9	1.9	-1.4	-0.6	-1.2	-0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.7	-0.7	-1.1	-1.6	0.4
Angina	0.5	0.6	1.4	-0.9	-1.2	0.2	-0.6
Medication for hormone replacement therapy	0.5	0.5	1.9	0.1	0.0	1.4	-0.5
Vitamin and mineral supplements	0.3	0.4	0.8	0.9	0.1	-0.2	0.9
Supplements: Zinc	0.4	0.4	1.0	-0.5	-0.5	-1.0	-0.2
Medication: Co-codamol	0.5	0.5	1.0	-0.6	-0.8	-1.0	0.4
Medication: Metformin	2.0	2.9	6.4	-1.2	-1.9	-2.5	-0.5
Diabetes (father)	1.4	1.8	3.6	0.2	-0.9	-1.6	-1.9
Diabetes (mother)	0.5	0.6	1.1	-0.7	0.9	-0.1	1.1
Severe depression (siblings)	3.2	3.5	8.0	2.8	1.8	0.1	1.7
Pack years adult smoking proportion	0.2	0.3	0.8	-0.5	0.5	0.9	0.1
Impedance of leg (right)	0.5	2.5	9.9	-3.1	-0.3	-0.0	-0.1
Leg fat-free mass (left)	0.0	0.1	0.3	0.0	-0.1	0.6	-0.5
Trunk fat percentage	1.8	7.1	25.3	-5.0	0.0	1.7	-0.4
Hand grip strength (right)	0.1	0.3	1.1	-0.2	0.5	1.0	0.1
Townsend deprivation index at recruitment	0.7	1.0	3.0	0.7	-0.7	-1.7	0.3
Current tobacco smoking	0.0	0.0	0.1	-0.2	0.1	-0.3	0.2
Average weekly fortified wine intake	0.8	1.0	2.9	-1.7	-0.6	0.8	-0.0
Maternal smoking around birth	0.3	0.5	1.0	0.7	0.5	0.2	1.0
Fed-up feelings	0.4	0.6	1.8	1.4	0.2	-0.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	6.7	2.6	0.9	-0.4	2.0
Relative age voice broke	1.3	2.1	3.2	1.4	1.8	0.5	1.7
Taking other prescription medications	0.2	0.3	1.0	-0.4	-0.2	-1.0	0.3
Age when periods started (menarche)	1.1	2.7	4.4	1.5	1.2	1.6	2.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.6	0.0	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.1	-0.8	-1.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	0.1	0.6	0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.3	-1.1	-0.7	0.2	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.5	-0.1	-0.1	-1.2	-0.1
High blood pressure	1.2	3.3	5.1	2.2	1.7	-0.6	2.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.9	-1.7	0.6	-0.8	0.8
Multivitamins +/- minerals	0.6	0.7	2.3	-0.6	-0.5	0.1	-1.5
Stomach or abdominal pain in last month	0.5	0.7	1.2	0.3	-0.7	-1.1	1.0
Supplements: Glucosamine	2.2	2.9	7.2	2.7	1.2	1.0	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.9	-1.4	0.2	0.4	0.0
Medication: Atenolol	0.3	0.4	0.5	-0.6	-0.6	-0.7	0.5
Medication: Levothyroxine sodium	0.5	0.9	2.6	0.7	-0.4	-1.6	-0.5
Sitting height	0.0	0.2	0.4	0.2	-0.6	-0.6	0.1
Chronic bronchitis/emphysema (father)	3.0	3.5	5.6	1.6	2.2	2.4	1.0
High blood pressure (mother)	1.6	2.3	5.2	1.5	1.2	-0.6	2.3
Body mass index (BMI)	0.3	1.3	4.4	-2.1	-0.6	0.7	-0.2
Impedance of leg (left)	0.6	3.1	11.6	-3.4	0.5	0.8	-0.2
Leg predicted mass (left)	0.0	0.1	0.3	-0.1	-0.2	0.5	-0.5
Trunk fat mass	1.2	5.1	18.1	-4.2	-0.5	1.3	-0.5
Waist circumference	0.7	2.5	8.7	-3.0	-0.3	0.9	-0.5
Number of incorrect matches in round	0.2	0.3	0.5	0.3	-0.5	0.6	0.7
Past tobacco smoking	0.2	0.4	1.6	-0.1	0.2	1.2	-0.3
Alcohol usually taken with meals	0.3	0.5	0.9	0.7	-0.9	-0.2	-0.7
Nervous feelings	0.0	0.1	0.2	-0.5	-0.1	0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.8	0.8	1.9	1.4	1.5
Hearing difficulty/problems with background noise	0.2	0.4	0.9	1.0	0.2	0.3	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.4	0.3	-0.6	0.7
Had menopause	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1
Had other major operations	0.3	0.4	0.8	0.9	-0.3	0.3	-0.7
Forced vital capacity (FVC)	0.0	0.2	0.5	0.3	0.3	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.5	0.7	0.6	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.1	0.1	-0.3	0.1
Qualifications: None of the above	1.0	2.1	3.3	0.5	1.8	1.5	1.6
Financial difficulties in last 2 years	0.7	1.0	2.2	1.5	-0.1	-1.3	0.4
Mouth/teeth dental problems	0.2	0.3	0.7	-0.4	0.5	0.2	-0.9
Heart attack	1.9	2.4	8.7	-0.1	0.9	0.5	2.9
Allergy	0.3	0.7	1.4	0.7	-1.2	0.2	-1.0
Pain all over the body in last month	0.7	0.8	1.9	-1.4	-0.1	0.1	1.1
Diabetes (self-reported)	3.1	4.8	8.1	-1.6	-2.4	-2.8	-1.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.7	1.9	0.9	-0.6	0.7
Medication: Ramipril	1.2	1.5	2.5	-1.6	1.5	1.1	0.3
Medication: Simvastatin	0.3	0.4	0.9	-0.3	-0.7	-0.9	-0.3
Fluid intelligence score	0.3	0.5	1.0	0.1	-0.6	-0.9	-1.0
Illnesses of siblings	0.7	1.0	1.8	-0.2	0.5	1.3	-1.3
Neuroticism score	0.1	0.3	0.3	0.5	-0.5	-0.5	0.6
Weight	0.3	1.5	5.6	-2.4	-0.5	0.6	-0.2
Impedance of arm (right)	0.4	1.6	5.3	-2.3	0.6	-0.3	-0.9
Arm fat percentage (right)	1.0	3.9	13.1	-3.6	-0.8	0.7	-1.1
Trunk fat-free mass	0.2	1.2	2.8	0.7	-1.7	-0.9	-0.9
Hip circumference	0.4	1.9	4.8	-2.2	0.3	1.5	0.7
Time employed in main current job	1.0	1.1	3.7	1.9	0.3	0.9	-0.0
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.8	-0.6	-0.1	0.3
Father’s age at death	0.1	0.2	0.4	0.1	0.3	-0.7	-0.4
Worrier / anxious feelings	0.2	0.3	0.7	0.2	-0.7	-0.2	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.7	-0.3	-0.2	0.9
Falls in the last year	0.3	0.4	1.3	-1.1	-0.4	0.3	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.4	-0.2	-0.9	0.3
Number of live births	0.2	0.3	0.6	-0.2	0.5	0.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.8	0.1	0.3	0.1	-0.9
Pulse rate	0.4	0.6	2.2	-1.5	-0.2	0.4	0.4
Happiness	0.1	0.1	0.3	-0.2	-0.3	-0.2	-0.5
Noisy workplace	2.5	3.1	8.4	-0.1	1.4	1.4	2.9
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.1	0.1	-1.3	-1.8	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.3	-0.6	0.4	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.1	-0.4	-0.4	0.8
Asthma	0.0	0.1	0.2	0.1	0.4	0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.0	0.8	2.0	0.9	0.1
Medication: Cholesterol lowering	1.1	1.7	2.7	-1.3	-1.6	-1.1	-1.1
Depression (self-reported)	0.6	0.7	1.6	-0.4	-1.1	-1.3	-0.1
Medication: Lansoprazole	0.4	0.5	0.9	1.0	-0.8	-0.6	-0.0
Prospective memory result	0.9	1.1	2.4	-0.1	-1.0	-1.5	1.0
Lung cancer (father)	3.3	3.8	6.2	0.5	1.9	2.3	2.5
Illnesses of mother	0.5	0.6	1.9	-1.4	-0.3	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.2	-0.6	-0.7	-0.6	-2.0
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	-0.4	0.4	0.8	1.6
Impedance of arm (left)	0.3	1.2	3.5	-1.9	1.1	-0.2	-0.6
Arm fat mass (right)	0.8	3.1	10.2	-3.2	-1.0	0.6	-0.9
Trunk predicted mass	0.2	1.3	3.1	0.7	-1.8	-0.9	-1.0
Standing height	0.0	0.3	0.7	-0.9	-0.2	-0.3	-0.6
Length of working week for main job	1.0	1.1	2.6	-0.2	1.6	0.8	1.1
Exposure to tobacco smoke at home	0.7	0.8	1.8	0.4	1.1	-0.0	1.4
Breastfed as a baby	0.1	0.1	0.3	0.4	0.5	0.3	0.1
Tense / ‘highly strung’	0.0	0.0	0.0	-0.0	0.1	-0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.5	-0.6	-1.0	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	0.6	0.5	0.7	-0.1
Birth weight of first child	1.4	2.6	4.3	-0.9	-2.0	-1.1	-2.1
Peak expiratory flow (PEF)	0.2	0.4	0.9	1.0	0.8	0.3	0.4
Pulse wave reflection index	0.1	0.1	0.4	0.2	-0.0	0.6	-0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	0.8	1.6	-0.5	0.1
Loud music exposure frequency	0.8	0.8	1.3	0.8	-1.2	-1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.4	-0.3	-0.7	-1.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.9	-1.0	-0.7	-0.6	0.8
Blood clot in the leg (DVT)	0.7	0.9	1.7	1.3	0.1	-0.4	-1.3
Medication: Paracetamol	1.0	1.7	5.0	-0.0	0.9	2.2	1.1
Headache pain in last month	1.3	2.2	3.9	1.4	1.5	0.8	2.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	-0.2	0.8	1.1	0.3
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	-0.3	-0.0	0.5
Gout (self-reported)	0.9	1.3	2.9	0.8	0.1	-1.7	1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.1	-0.5	-0.3	-1.0	-0.7
Medication: Amlodipine	0.5	0.6	1.8	1.4	-0.5	0.6	-0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.9	0.2	-1.1	-0.2	-1.7
Birth weight	0.3	0.5	1.7	-0.7	-0.2	0.1	-1.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.1	-1.1	-1.1	-0.1	-1.8
High blood pressure (siblings)	0.2	0.2	0.5	-0.4	-0.3	-0.7	0.4
Forced vital capacity (FVC), Best measure	0.4	1.6	5.2	-0.6	-0.8	-0.6	-2.3
Body fat percentage	1.8	7.0	25.4	-5.0	-0.3	1.6	-0.2
Leg fat percentage (right)	2.0	7.2	25.6	-5.1	-1.3	1.2	-0.1
Arm fat-free mass (right)	0.1	0.6	1.0	-0.6	-1.0	0.7	-0.7
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.5	-0.7	-0.1	-0.5
Comparative body size at age 10	0.3	0.7	2.0	-1.4	-0.1	0.9	-0.3
Number of full brothers	1.3	1.6	2.5	1.6	0.2	-1.1	1.6
Worry too long after embarrassment	2.5	4.2	8.8	3.0	1.6	1.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	0.3	-0.4	0.1
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	0.7	0.2	-0.7	-1.1
Number of children fathered	1.0	1.1	2.3	0.9	1.5	0.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	0.4	0.4	1.2	-0.1
Age at first live birth	0.1	0.2	0.4	0.6	0.4	0.4	0.0
Pulse wave peak to peak time	0.8	0.9	2.7	0.4	-0.3	-0.8	-1.6
Health satisfaction	0.2	0.2	0.6	-0.8	-0.1	0.1	-0.5
Shortness of breath walking on level ground	0.6	0.7	1.1	-0.4	1.1	0.8	0.9
Qualifications: College or University degree	1.1	3.6	11.1	-0.7	-1.2	-1.1	-3.3
Eye problems/disorders: None of the above	3.1	3.5	6.5	1.6	2.3	2.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.4	-0.4	0.1	-0.2	1.8
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.4	0.8	0.1	0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	2.0	0.4	0.1	-1.4	-0.2
Neck or shoulder pain in last month	1.1	1.5	4.8	2.2	0.8	0.6	0.5
Medication: Blood pressure	0.3	0.6	1.3	0.7	-0.6	-1.2	0.2
Angina (self-reported)	0.3	0.4	0.7	-0.7	-0.9	0.4	-0.1
Migraine (self-reported)	0.7	0.8	2.4	-0.9	1.6	-0.0	0.2
Medication: Ibuprofen	0.6	0.7	1.8	0.8	1.3	0.7	-0.0
Medication: Allopurinol	1.5	2.0	5.6	0.2	-1.4	-2.4	-0.7
Medication: Omeprazole	0.5	0.6	1.3	-1.1	-0.8	0.5	-0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.1	0.1	-0.1	-0.9
Mean time to correctly identify matches	0.3	0.6	1.1	-0.7	-1.1	-0.8	-0.5
Heart disease (mother)	1.0	1.3	4.1	0.3	-1.0	-2.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	1.2	0.2	-0.7	0.4
Whole body fat mass	1.2	4.9	17.3	-4.2	-0.6	1.3	-0.5
Leg fat mass (right)	1.2	4.5	15.1	-3.9	-0.7	1.5	-0.1
Arm predicted mass (right)	0.1	0.4	0.8	-0.3	-0.9	0.6	-0.3
Pulse rate, automated reading	0.1	0.3	0.7	-0.8	-0.6	0.1	-0.2
Alcohol intake frequency.	0.5	1.1	3.8	-1.9	-0.7	-0.3	0.1
Comparative height size at age 10	0.6	3.1	10.2	-3.2	-0.6	-0.0	-1.4
Number of full sisters	2.7	3.3	6.9	2.1	1.5	-0.2	2.6
Suffer from ‘nerves’	0.7	1.1	3.6	0.2	-0.3	-0.7	1.9
Overall health rating	0.3	0.7	2.6	-0.4	0.3	-0.2	1.6
Chest pain or discomfort	0.3	0.4	1.1	1.1	0.1	0.4	0.7
Had major operations	0.5	0.6	2.1	1.4	-0.3	-0.4	0.0
Age at last live birth	0.9	1.3	5.0	0.2	-0.2	0.2	-2.2
Family relationship satisfaction	2.2	2.7	5.9	-0.1	-1.9	-1.1	-2.4
Leg pain on walking	0.1	0.1	0.2	-0.2	0.4	-0.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.0	-0.3	-0.8	1.1
Commuting to job workplace: Car/motor vehicle	1.8	2.1	5.4	1.0	1.1	2.3	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.1	0.6	0.3	-1.0
Medication: Aspirin	0.1	0.2	0.5	-0.3	-0.7	0.3	0.0
Supplements: Vitamin C	1.2	1.4	3.0	-1.7	-0.5	-0.9	-1.3
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	0.0	0.4	0.1
Hypertension (Self-reported)	1.1	3.1	5.2	1.9	1.8	-0.6	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	0.3	-0.1	-0.6	0.4
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.9	0.8	0.5	0.8
Illnesses of siblings: Diabetes	1.0	1.3	3.3	0.8	0.8	-0.7	1.8
Smoking status: Previous	0.2	0.3	0.5	0.5	0.2	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.2	-0.6	-1.1	-0.9	-0.7
Whole body fat-free mass	0.1	0.3	0.8	0.3	-0.9	-0.1	-0.7
Leg fat-free mass (right)	0.0	0.2	0.5	0.4	0.3	0.7	-0.4
Arm fat percentage (left)	0.9	3.6	12.7	-3.6	-0.6	1.0	-0.7
Average weekly red wine intake	0.9	1.3	2.0	0.2	-1.4	-1.4	-1.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	0.7	-0.1	-0.8	-0.1
Mood swings	0.4	0.7	1.6	0.7	-0.5	-1.3	-0.5
Loneliness, isolation	1.5	2.1	5.2	-1.2	-1.2	0.2	-2.3
Long-standing illness, disability or infirmity	0.2	0.2	0.6	-0.8	-0.2	-0.6	-0.1
Ever had bowel cancer screening	0.2	0.2	0.6	-0.8	0.4	0.3	0.1
Diabetes diagnosed by doctor	2.7	4.4	8.1	-1.4	-2.2	-2.9	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.9	-1.4	0.3	-0.0	-0.1
Friendships satisfaction	0.8	1.0	2.5	-0.4	-0.6	-1.0	-1.6
Qualifications: nursing, teaching	0.3	0.5	1.0	1.0	-0.2	-0.8	0.5
Commuting to job workplace: Walk	0.6	0.6	1.4	0.2	-0.9	-1.2	-0.6
Eye problems/disorders: Cataract	1.3	1.5	4.6	-0.8	-2.1	-0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	1.5	0.7	0.5	0.1
Medication for cholesterol	0.7	1.1	2.9	-0.4	-1.2	-1.7	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.5	0.1	-1.9	-0.8	-0.4
Back pain experienced in last month	1.0	1.5	3.5	1.1	1.2	-0.1	1.9
Mineral and other dietary supplements	0.2	0.2	0.8	-0.9	-0.3	0.2	-0.1
Breast cancer (self-reported)	1.0	1.2	3.2	1.8	-0.8	-0.6	-0.9
Asthma (self-reported)	0.0	0.1	0.2	0.3	0.4	-0.0	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.4	0.7	0.6	-0.1	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.3	1.1	-0.4	-0.5	-0.5
Medication: Aspirin	0.3	0.4	1.6	-0.3	-1.2	-0.1	-0.3
Medication: Gliclazide	1.4	1.6	2.5	-1.6	-1.3	-0.3	-1.5
Illnesses of father: None of the above (group 1)	1.2	1.5	4.1	0.6	-0.9	-2.0	0.7
Smoking status: Current	0.0	0.1	0.2	-0.3	-0.1	-0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	0.3	1.3	0.6	0.1
Whole body water mass	0.1	0.4	0.9	0.3	-0.9	-0.1	-0.7
Leg predicted mass (right)	0.0	0.2	0.4	0.4	0.3	0.6	-0.4
Arm fat mass (left)	0.8	3.2	10.8	-3.3	-1.0	0.5	-1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	1.0	0.7	-0.5	0.5
Average weekly champagne plus white wine intake	1.4	1.9	4.1	1.2	-1.4	-2.0	-0.3
Miserableness	0.3	0.6	1.2	1.0	0.2	-0.2	1.1
Guilty feelings	0.6	1.0	2.6	1.0	0.5	0.3	1.6
Wears glasses or contact lenses	0.2	0.2	0.8	-0.1	-0.0	-0.2	0.9
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.1	0.4	-0.2	0.1
Hearing aid user	0.8	0.9	2.4	-0.9	-0.5	0.4	-1.6
Mother’s age at death	0.4	0.5	0.8	-0.8	-0.6	-0.3	-0.9
Financial situation satisfaction	0.4	0.5	0.8	0.1	-0.7	-0.9	-0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	0.0	-0.2	-0.6
Commuting to job workplace: Public transport	0.9	1.1	2.9	1.1	-0.3	-1.7	-0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	0.0	0.3	0.1	1.2
Medication: Blood pressure	0.2	0.4	1.1	0.1	1.1	0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.7	0.2	1.3	1.1	1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	0.9	-0.4	-1.4	0.7
High cholesterol (Self-reported)	0.3	0.6	1.1	-0.8	-0.3	1.1	-0.7
Medication: Bendroflumethiazide	1.8	2.8	5.5	-0.6	-2.3	-1.9	-1.3
Medication: Paracetamol	1.0	1.6	4.2	-0.2	0.7	2.0	1.2
Medication: Lisinopril	3.2	4.2	9.6	-0.7	-2.5	-3.1	-0.2
Medication: Atorvastatin	0.8	1.0	2.4	-0.7	-0.9	-0.4	-1.6
Illnesses of father: High blood pressure	1.7	2.1	6.0	-0.0	-1.4	-0.6	-2.4
Alcohol drinker status: Never	0.4	0.4	1.0	-1.0	-0.2	-0.8	-0.3
Ever smoked	0.9	1.5	4.4	0.1	-1.2	-2.1	0.4
Basal metabolic rate	0.1	0.3	0.7	-0.5	-0.8	0.0	-0.6
Leg fat percentage (left)	2.1	7.5	26.6	-5.2	-0.9	1.6	-0.2
Arm fat-free mass (left)	0.1	0.7	1.3	-1.0	-1.1	0.3	-0.7
Number of operations (self-reported)	0.8	1.2	2.7	1.6	-0.9	0.3	-1.1
Average weekly beer plus cider intake	0.8	1.1	2.8	1.7	0.6	1.0	0.6
Irritability	0.2	0.3	0.5	-0.7	0.7	0.3	-0.2
Risk taking	0.2	0.2	0.5	0.3	-0.1	0.7	-0.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.4	1.6	0.9	0.8	1.1
Fractured/broken bones in last 5 years	0.3	0.4	1.3	1.2	-0.2	-0.5	-0.0
Age started oral contraceptive pill	0.8	1.1	2.1	-1.4	0.9	0.9	0.6
Diastolic blood pressure, automated reading	0.2	0.5	1.3	-0.8	0.3	0.5	1.1
Ever depressed for a whole week	0.3	0.4	1.3	0.1	1.1	-0.0	0.4
Unable to work because of sickness or disability	0.3	0.3	0.6	0.5	0.2	-0.7	0.8
Commuting to job workplace: Cycle	0.5	0.6	2.1	-0.2	-0.5	-1.5	-0.3
Myopia	1.6	2.3	5.1	2.2	-0.0	-0.4	-2.0
Vascular/heart problems diagnosed by doctor	1.1	3.0	4.7	-2.0	-1.7	0.2	-2.2
Cholesterol lowering medication	0.3	0.4	1.6	-0.2	-0.2	0.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-1.1	-1.0	-0.1	-0.4
Pain experienced in last month	0.7	1.1	1.3	-1.1	-0.9	-1.1	-1.2
Supplements: Calcium	4.2	4.7	10.0	1.6	2.3	1.0	3.2
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	-0.6	-0.4	0.2	-1.4
Heart attack/myocardial infarction (self-reported)	1.7	2.2	7.9	-0.0	0.9	0.3	2.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.2	1.1	0.2	-0.3	-1.1
Heart disease (siblings)	1.1	1.3	3.2	0.1	-1.0	-1.8	1.1
Alcohol drinker status: Previous	1.0	1.2	3.9	0.2	0.8	0.1	2.0
Pack years of smoking	0.2	0.3	0.5	-0.6	0.4	0.7	-0.0
Impedance of whole body	0.5	2.7	10.0	-3.2	0.8	0.4	-0.3
Leg fat mass (left)	1.2	4.7	15.7	-4.0	-0.4	1.7	-0.1
Arm predicted mass (left)	0.1	0.6	1.0	-1.0	-0.8	0.5	-0.6