TWAS hub - SIKE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0330	0.00080	0.019	0.034	0.015	0.038	0.030	0.00200	4.4e-05	4.8e-03	1.8e-05	0.00014
2	GTEx	Artery Aorta	0.0900	0.0410	0.00550	-0.004	NA	0.014	NA	0.002	0.67000	NA	5.1e-02	NA	0.23000
3	GTEx	Artery Tibial	0.0746	0.0273	0.00011	0.059	NA	0.057	NA	0.057	0.00002	NA	2.9e-05	NA	0.00003
4	GTEx	Ovary	0.1840	0.0810	0.00380	0.075	NA	-0.001	NA	-0.009	0.00680	NA	3.5e-01	NA	0.63000
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.4420	0.1630	0.00250	0.090	0.064	0.114	NA	0.129	0.00170	7.2e-03	4.5e-04	NA	0.00019

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Ever had prostate specific antigen (PSA) test	7.4	8.5	14.3	3.5	2.2	3.8	2.9	1.6
Alcohol usually taken with meals	7.3	11.8	23.1	2.6	2.6	4.2	2.3	4.8
Average weekly beer plus cider intake	5.6	8.0	23.3	-2.1	-0.2	-3.4	-0.8	-4.8
Average weekly champagne plus white wine intake	5.3	7.2	16.6	1.7	1.8	4.1	2.9	2.2
Falls in the last year	5.1	6.9	12.0	-3.3	-0.8	-3.5	-2.6	-2.1
Noisy workplace	5.1	6.2	11.1	-1.3	-1.6	-2.6	-2.9	-3.3
Frequency of tenseness / restlessness in last 2 weeks	4.6	7.2	11.8	-1.7	-3.2	-3.4	-2.8	-1.7
Age at First Birth	4.4	6.3	11.7	2.5	1.1	3.4	2.6	2.4
Qualifications: O levels/GCSEs or equivalent	4.3	6.8	25.3	1.1	-0.4	2.7	0.1	5.0
Handedness (chirality/laterality): Left-handed	4.3	5.2	6.7	2.6	2.1	2.5	2.4	1.6
Bipolar Disorder or Schizophrenia	4.2	10.1	18.7	2.5	2.9	4.3	1.1	4.0
Neck or shoulder pain in last month	4.1	5.8	12.3	-1.8	-2.9	-3.5	-2.3	0.1
Number of full sisters	4.1	5.0	8.9	-3.0	-1.9	-2.0	-2.8	-0.6
Bipolar Disorder (2011)	4.0	3.9	8.8	2.0	0.9	3.0	1.2	2.1
Qualifications: A levels/AS levels or equivalent	3.8	8.5	17.4	2.3	1.4	3.8	1.8	4.2
Supplements: Calcium	3.7	4.1	7.4	2.0	1.7	2.7	2.3	1.1
Chronic bronchitis/emphysema (father)	3.5	4.1	8.9	-1.4	-2.4	-2.0	-3.0	-0.1
Chronotype (morning person)	3.4	7.9	15.7	-1.3	-3.9	-2.5	-4.0	0.4
Leg fat mass (right)	3.4	13.1	38.2	-2.6	0.9	-4.4	-0.5	-6.2
Wheeze or whistling in the chest in last year	3.3	6.0	11.5	-3.4	-1.6	-2.8	-2.1	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	3.3	3.5	6.5	-2.5	-2.3	-2.1	-1.0	0.6
Tinnitus: Yes, now most or all of the time	3.2	3.7	9.1	-1.9	-1.2	-1.9	-3.0	-0.7
Bipolar Disorder (2018)	3.1	5.0	12.0	1.5	1.4	3.5	1.0	2.7
Schizophrenia (2014)	3.1	6.9	10.0	2.3	3.1	3.2	1.1	3.0
Medication: Co-codamol	3.1	3.5	8.6	-0.7	-2.2	-1.9	-2.9	0.3
Waist circumference	3.1	11.5	34.6	-2.7	1.1	-3.8	-0.6	-5.9
Happiness	3.1	3.8	6.4	-1.6	-2.5	-2.1	-2.3	0.4
Age at last live birth	3.1	4.5	9.9	0.8	1.1	2.7	3.1	2.0
Leg pain on walking	3.1	3.9	7.7	-1.7	-0.6	-2.8	-1.4	-2.5
Fractured/broken bones in last 5 years	3.1	4.0	6.6	-1.8	-1.1	-2.2	-2.0	-2.6
Leg fat mass (left)	3.1	12.2	35.7	-2.5	0.6	-4.3	-0.5	-6.0
Diabetes (father)	3.0	3.7	6.7	-2.3	-2.6	-1.5	-2.1	-0.2
Current tobacco smoking	3.0	4.9	10.0	-1.2	-1.6	-2.5	-1.9	-3.2
Emphysema/chronic bronchitis	3.0	3.3	6.3	-2.5	-1.9	-0.8	-2.1	1.3
Leg fat percentage (right)	2.9	10.4	31.4	-2.4	1.4	-3.6	-0.3	-5.6
Body mass index (BMI)	2.8	12.1	35.5	-2.4	0.7	-4.3	-0.7	-6.0
Overall health rating	2.8	6.1	9.5	-2.5	-2.3	-2.9	-3.1	-0.9
Smoking status: Current	2.8	4.4	10.3	-0.8	-1.7	-2.3	-1.7	-3.2
Leg fat percentage (left)	2.7	9.8	29.3	-2.3	1.0	-3.6	-0.2	-5.4
Schizophrenia (2018)	2.6	5.4	8.6	2.0	2.6	2.8	0.6	2.9
BMI	2.6	15.1	40.7	-2.7	0.1	-5.1	-1.3	-6.4
Serious illness, injury or assault to yourself	2.6	3.1	6.6	-1.5	-2.6	-2.3	-1.0	-0.4
Qualifications: None of the above	2.6	5.5	17.5	-0.9	-0.5	-2.8	-1.1	-4.2
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	8.8	-0.4	-2.9	-1.0	-3.0	1.6
Arm fat mass (right)	2.6	10.7	28.8	-2.7	0.4	-4.1	-0.7	-5.4
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	6.6	-2.6	-2.4	-2.2	-2.1	-0.4
Age at first live birth	2.6	4.7	12.3	0.1	1.4	3.5	2.0	2.3
Back pain experienced in last month	2.6	3.9	11.8	-1.7	-3.4	-1.2	-0.6	1.6
Fed-up feelings	2.5	4.5	11.8	-0.1	-2.1	-3.4	-1.0	-2.3
Illnesses of siblings	2.5	3.5	8.5	0.6	1.2	2.9	1.1	2.4
Health satisfaction	2.5	3.3	8.1	-2.9	-0.4	-1.4	-2.4	-0.5
Medication: Blood pressure	2.5	4.3	7.2	2.0	2.3	2.7	2.1	0.7
Family relationship satisfaction	2.5	3.1	5.4	-2.3	-1.5	-2.0	-1.8	-0.6
Loneliness, isolation	2.5	3.5	8.0	0.2	-1.7	-2.8	-1.1	-2.3
Breast cancer (self-reported)	2.5	2.9	5.1	-0.5	-1.8	-2.0	-1.4	-2.3
Basal cell carcinoma (self-reported)	2.5	3.0	5.5	2.4	1.7	1.9	1.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.4	0.4	-1.6	-2.5	-1.2	-2.3
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	4.0	-1.9	0.4	-2.0	-1.6	-1.6
Had other major operations	2.4	2.9	6.8	-2.1	-1.2	-1.2	-2.6	0.6
Headache pain in last month	2.4	4.2	13.7	3.7	-1.6	-0.0	0.3	2.1
Qualifications: nursing, teaching	2.4	3.7	9.0	0.8	0.4	3.0	1.2	2.7
Arm fat mass (left)	2.4	9.8	28.2	-2.4	0.6	-3.8	-0.4	-5.3
Coronary Artery Disease (CAD)	2.3	2.7	5.1	1.2	1.3	1.7	1.6	2.3
Hearing difficulty/problems with background noise	2.3	3.8	7.0	-2.3	-1.1	-2.1	-2.6	-1.0
Medication: Simvastatin	2.3	3.4	6.9	2.6	1.3	1.7	2.1	0.9
Whole body fat mass	2.3	9.5	26.6	-2.5	0.5	-3.7	-0.5	-5.2
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	5.0	-0.9	-1.6	-2.2	-1.4	-1.9
Pain all over the body in last month	2.2	2.3	6.4	1.1	2.5	0.7	1.1	-1.6
Weight	2.2	10.8	29.0	-2.3	-0.4	-4.4	-0.5	-5.4
Average weekly spirits intake	2.1	2.5	5.0	-1.1	-0.7	-2.2	-1.1	-2.2
Qualifications: College or University degree	2.1	6.6	10.8	1.6	1.4	3.3	2.9	3.0
Medication: Aspirin	2.1	2.7	6.0	2.4	1.5	1.1	1.9	0.4
Depressed Affect (Nagel 2018)	2.0	4.2	9.0	-0.2	-1.5	-3.0	-1.2	-2.9
Medication for hormone replacement therapy	2.0	2.3	3.9	-1.5	-1.4	-0.1	-1.8	2.0
Trunk fat mass	2.0	8.6	24.6	-2.5	0.3	-3.5	-0.4	-5.0
Nervous feelings	2.0	3.8	7.2	1.5	0.4	2.6	1.7	2.7
Arm fat percentage (right)	2.0	7.9	20.4	-2.7	0.9	-3.2	-0.7	-4.5
Body fat percentage	2.0	8.0	22.2	-2.5	0.9	-3.2	-0.5	-4.7
Knee pain experienced in last month	2.0	3.1	6.4	-2.5	-1.2	-1.8	-2.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	6.2	-2.5	-0.5	-1.3	-1.9	-0.3
Pain experienced in last month	2.0	3.4	10.3	1.0	3.2	1.2	0.8	-1.9
Shortness of breath walking on level ground	1.9	2.3	7.0	-1.2	1.0	-1.1	-0.9	-2.6
Medication: Omeprazole	1.9	2.3	7.3	-2.7	-0.9	-0.8	-1.6	0.0
Heart disease (mother)	1.9	2.4	4.5	1.1	1.6	1.9	0.1	2.1
Illnesses of siblings: Diabetes	1.9	2.4	7.0	-0.3	1.1	-1.8	0.4	-2.6
Arm fat percentage (left)	1.9	7.5	21.3	-2.4	1.1	-3.0	-0.6	-4.6
Arm predicted mass (left)	1.9	9.7	24.9	-1.8	-1.3	-4.3	-0.1	-5.0
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.2	-2.0	-1.1	-2.0	-1.2	-0.6
Hip circumference	1.8	7.8	21.1	-2.1	0.2	-3.7	-0.2	-4.6
Medication: Cholesterol lowering	1.8	2.8	6.7	2.3	2.6	0.8	1.1	-0.3
Prospective memory result	1.8	2.2	8.1	1.2	0.6	0.9	2.8	0.5
High blood pressure (siblings)	1.8	2.6	5.5	-0.3	-1.6	-2.4	-1.3	-1.7
Comparative body size at age 10	1.8	4.9	9.4	-2.2	0.1	-3.1	-2.5	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.4	-2.5	-1.1	-1.1	-0.8	-0.8
Wears glasses or contact lenses	1.8	2.0	4.0	1.8	0.6	2.0	1.3	0.9
Arm fat-free mass (left)	1.8	9.2	25.2	-1.5	-1.3	-4.1	0.2	-5.0
Severe depression (siblings)	1.7	1.9	4.2	2.0	0.6	1.3	0.7	1.6
Maternal smoking around birth	1.7	2.5	7.2	-2.7	-0.3	-2.0	-0.5	-1.1
Relative age voice broke	1.7	2.6	5.2	2.0	1.1	2.3	0.9	1.3
Arm fat-free mass (right)	1.7	8.9	26.4	-1.3	-1.0	-3.9	0.1	-5.1
Arm predicted mass (right)	1.7	8.9	26.7	-1.5	-1.1	-3.8	0.1	-5.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	3.2	-1.6	-1.5	-1.8	-1.8	0.3
Trunk fat percentage	1.6	6.3	17.6	-2.3	0.7	-2.8	-0.6	-4.2
Impedance of arm (left)	1.6	7.2	20.9	1.2	0.3	3.6	0.4	4.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	7.5	-0.6	-1.2	-1.1	-2.7	1.2
Blood clot in the leg (DVT)	1.6	2.1	4.2	-1.9	-0.2	-1.0	-2.0	-1.2
Basal metabolic rate	1.6	9.0	23.3	-1.8	-1.2	-4.1	-0.2	-4.8
Unable to work because of sickness or disability	1.6	2.1	3.6	-1.0	-1.5	-1.9	-1.9	-0.5
Depression (Nagel 2018)	1.5	2.3	5.2	-0.4	-1.0	-2.3	-1.2	-2.0
Relative age of first facial hair	1.5	3.1	8.3	1.2	2.1	2.9	0.6	1.1
High blood pressure (mother)	1.5	2.1	3.8	-2.0	-1.4	-1.8	-1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.2	0.2	-0.8	-1.5	-1.8	-1.8
Medication: Ramipril	1.5	1.9	4.5	1.0	2.1	1.2	1.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.5	1.1	-1.3	-1.6	-1.6	-1.2
Medication: Ibuprofen	1.5	1.8	2.9	0.7	-1.7	-1.6	-1.3	-1.2
Friendships satisfaction	1.5	1.9	4.1	-2.0	-1.0	-1.7	-0.7	-0.9
Medication: Gliclazide	1.5	1.8	4.9	-2.2	-0.7	-0.3	-1.1	-1.4
Guilty feelings	1.5	2.3	5.2	-0.6	-2.3	-1.6	-1.2	-1.3
Irritability	1.5	2.5	3.6	-0.6	-1.8	-1.8	-1.4	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.7	-1.7	-0.2	-1.1	-1.9	-1.2
Major Depression (MDD)	1.4	1.7	2.4	1.6	-0.4	1.4	1.4	1.5
Leg fat-free mass (left)	1.4	7.4	17.6	-1.9	-1.0	-3.7	-0.8	-4.2
Leg predicted mass (left)	1.4	7.4	17.9	-1.9	-1.1	-3.7	-0.8	-4.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.4	-2.1	-1.5	-1.1	0.4	0.1
Medication: Amlodipine	1.4	2.0	5.6	1.6	0.2	2.4	0.6	1.1
Whole body fat-free mass	1.4	7.8	20.4	-1.6	-1.4	-3.8	0.0	-4.5
Osteoporosis (self-reported)	1.4	1.7	2.9	1.4	0.7	1.7	1.7	-0.8
Whole body water mass	1.4	8.0	20.9	-1.6	-1.4	-3.9	0.0	-4.6
Miserableness	1.4	2.4	5.3	-0.7	-2.0	-2.3	-1.5	-0.6
Alcohol drinker status: Previous	1.4	1.6	3.6	1.5	-0.5	1.4	0.5	1.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.5	-1.4	-1.1	-1.8	-1.6	-1.9
Medication: Atenolol	1.3	1.6	3.6	1.9	-0.2	1.4	1.2	1.0
Financial difficulties in last 2 years	1.3	1.8	4.6	0.0	-1.1	-2.1	-1.7	-0.7
Leg fat-free mass (right)	1.3	6.9	14.9	-1.8	-1.5	-3.7	-0.7	-3.9
Leg predicted mass (right)	1.3	6.8	14.7	-1.8	-1.4	-3.7	-0.8	-3.8
Number of operations (self-reported)	1.3	1.9	4.1	-2.0	-1.2	-1.5	-0.9	-0.9
Smoking Status	1.2	2.8	7.3	-0.9	-1.4	-1.8	-0.8	-2.7
Impedance of arm (right)	1.2	5.7	19.4	0.7	0.0	3.0	0.1	4.4
Pulse rate	1.2	2.0	3.9	-1.8	-0.8	-1.4	-2.0	-0.6
Trunk predicted mass	1.2	6.8	17.9	-1.1	-1.5	-3.5	0.5	-4.2
Exposure to tobacco smoke outside home	1.2	1.6	4.8	-0.6	-2.2	-1.3	0.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	6.7	2.6	-0.1	0.3	0.7	0.6
Impedance of whole body	1.2	6.0	17.6	1.2	0.2	3.2	0.7	4.2
Worry (Nagel 2018)	1.1	2.3	4.6	1.2	-1.6	1.8	0.5	2.1
Stomach or abdominal pain in last month	1.1	1.4	5.0	-2.2	-0.5	-1.2	-0.1	0.3
Trunk fat-free mass	1.1	6.6	17.3	-1.0	-1.5	-3.5	0.5	-4.2
Forced vital capacity (FVC), Best measure	1.1	4.0	8.6	-2.9	-2.1	-1.9	-1.8	-0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	2.1	1.2	0.9	0.6	1.4	-1.4
Mother’s age at death	1.1	1.4	2.6	0.2	1.6	1.5	0.6	1.3
Illnesses of father: High blood pressure	1.1	1.4	3.4	1.2	-1.9	-0.4	0.1	1.3
Alzheimer’s Disease (in father)	1.0	1.1	4.2	-0.8	0.5	-0.6	0.0	-2.0
Lung FVC	1.0	5.2	11.3	-3.1	-1.8	-1.4	-3.4	0.2
Medication: Metformin	1.0	1.4	2.8	-1.7	-0.6	-0.9	-0.9	-1.5
Sitting height	1.0	6.8	11.7	-2.6	-3.4	-3.3	-2.1	-0.4
Forced vital capacity (FVC)	1.0	3.7	6.6	-2.0	-2.6	-1.9	-2.1	0.1
Tense / ‘highly strung’	1.0	1.6	4.2	0.8	-1.3	0.9	-0.7	2.1
Number of full brothers	1.0	1.3	2.0	-1.1	-1.2	-1.4	-1.4	-0.4
Average weekly red wine intake	1.0	1.5	3.3	0.5	1.4	1.8	0.7	1.2
Commuting to job workplace: Walk	1.0	1.0	2.5	-1.2	-0.1	1.0	0.5	1.6
Financial situation satisfaction	1.0	1.2	2.1	-0.3	0.4	-1.4	-1.3	-1.5
Diastolic blood pressure, automated reading	1.0	3.0	6.9	-1.8	-1.3	-1.5	1.0	-2.6
Reaction Time	0.9	1.7	5.2	-0.0	1.2	0.6	2.3	-1.3
Prostate Cancer	0.9	1.3	3.6	0.3	1.9	0.4	1.2	-1.2
Average weekly fortified wine intake	0.9	1.1	3.3	0.1	0.7	1.0	1.8	0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.7	1.3	0.9	-0.1	1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.5	-1.6	-2.1	-0.9	0.5	1.3
Worrier / anxious feelings	0.9	1.8	3.7	1.1	0.0	1.9	0.7	1.9
Gout (self-reported)	0.9	1.2	2.4	1.6	0.4	1.4	0.7	1.0
Eye problems/disorders: None of the above	0.9	1.0	2.8	1.7	0.4	1.2	0.3	0.8
Had major operations	0.9	1.1	2.0	-0.9	0.9	-0.5	1.4	-1.2
Medication: Aspirin	0.9	1.3	2.2	1.4	1.5	0.4	1.4	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.9	-1.7	-0.3	-1.1	-0.4	1.1
Alzheimer’s Disease (including proxy)	0.8	1.1	3.7	-0.9	-0.0	-0.6	-0.9	-1.9
Neuroticism (2016)	0.8	1.1	2.8	0.2	-0.3	-1.7	0.1	-1.6
Lung FEV1/FVC ratio	0.8	4.0	11.3	-0.5	2.1	0.7	1.8	-3.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	-0.5	-0.8	-1.3	-1.2	-0.7
Angina	0.8	1.1	3.6	1.3	1.9	-0.0	-0.1	0.3
Townsend deprivation index at recruitment	0.8	1.2	2.7	-1.1	-0.8	-1.6	-1.1	0.2
Multivitamins +/- minerals	0.8	1.0	1.8	1.4	0.5	1.1	1.1	0.8
Mouth/teeth dental problems	0.8	1.3	3.8	-0.5	1.0	2.0	0.4	1.1
Father’s age at death	0.8	1.1	2.3	0.2	1.2	1.5	0.0	1.4
Number of live births	0.8	1.2	3.6	-0.1	-1.9	-0.4	-0.5	1.4
Asthma	0.8	1.6	4.8	-2.2	-0.4	-0.8	0.5	-1.6
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	-0.8	-0.4	-1.6	-0.7	-1.0
Medication for pain relief, constipation, heartburn	0.8	1.4	4.0	-0.4	0.7	2.0	0.2	1.5
Angina (self-reported)	0.8	1.0	3.8	1.1	1.9	-0.2	-0.3	-0.0
Migraine (self-reported)	0.8	1.0	4.5	2.1	-0.1	0.1	-0.6	0.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	3.1	0.3	1.0	1.7	-0.2	0.6
Illnesses of father: Heart disease	0.8	1.1	2.9	-0.5	-0.2	-0.7	-1.3	1.7
Neuroticism (Nagel 2018)	0.7	1.6	4.6	0.2	-2.1	-1.1	-0.5	-1.3
Hearing difficulty/problems: Yes	0.7	1.1	2.8	-0.5	-0.8	-1.3	-1.7	-0.0
Vitamin and mineral supplements	0.7	1.0	1.8	-1.3	-0.7	-1.1	-1.2	-0.1
Age when periods started (menarche)	0.7	1.6	4.6	1.5	0.6	0.7	2.1	0.3
Had menopause	0.7	0.9	1.4	-1.2	-1.0	-0.9	-1.1	-0.1
Allergy	0.7	1.5	4.3	2.1	0.5	0.9	-0.2	1.5
Length of working week for main job	0.7	0.7	2.3	0.9	0.4	-0.5	0.4	-1.5
Alcohol intake frequency.	0.7	1.6	3.9	2.0	-0.1	0.4	-0.1	2.0
Ever had bowel cancer screening	0.7	0.8	2.1	-1.1	-0.2	0.6	0.7	1.5
Asthma (self-reported)	0.7	1.4	4.1	-2.0	-0.4	-0.8	0.4	-1.4
Alcohol drinker status: Never	0.7	0.8	3.9	-0.2	-0.0	-0.5	-2.0	0.2
Heart disease (siblings)	0.7	0.9	2.3	0.0	-0.7	-1.2	-1.5	-0.3
Rheumatoid Arthritis	0.6	0.8	3.2	0.2	0.0	-0.8	0.1	-1.8
Blood Platelet Count	0.6	6.5	14.4	-3.8	-1.3	-3.2	-1.7	-1.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.4	0.6	-1.2	-1.5	-0.0	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	0.4	-1.5	-0.1	-0.2	1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	0.7	-0.3	-0.4	0.1	-1.6
Taking other prescription medications	0.6	0.9	1.0	1.0	0.9	1.0	0.8	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	0.1	0.5	0.9	1.6	-0.0
Heart attack	0.6	0.7	1.2	1.1	0.9	1.0	0.7	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	1.9	0.3	1.2	0.3	1.4	-1.0
Medication: Lansoprazole	0.6	0.6	1.2	0.8	0.1	1.1	0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	6.3	-2.5	-1.0	-0.8	-0.9	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	3.3	0.7	1.5	1.8	0.2	1.2
Loud music exposure frequency	0.6	0.6	1.4	-0.3	-0.1	-0.9	-1.2	-0.9
Medication: Paracetamol	0.6	1.0	2.1	1.0	-1.5	-1.2	-0.6	0.3
Glaucoma (self-reported)	0.6	0.7	1.6	-0.7	-1.3	-0.5	-0.8	0.7
Worry too long after embarrassment	0.6	1.0	2.3	0.7	-0.3	1.2	1.5	0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-0.3	-1.1	-0.5	-1.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.2	-0.6	-0.5	-0.1	-1.5	0.9
Suffer from ‘nerves’	0.6	0.9	2.1	0.5	-1.4	0.5	-0.7	1.3
Eye problems/disorders: Cataract	0.6	0.7	2.0	-0.7	-0.2	-1.4	0.0	-1.0
Medication for cholesterol	0.6	0.9	3.0	0.0	1.7	0.7	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.5	-1.2	0.3	-0.6	-1.2	-1.6
Ever taken oral contraceptive pill	0.6	0.7	1.2	-0.3	1.0	-1.1	0.1	-1.0
Hearing aid user	0.6	0.6	2.5	0.6	-0.3	0.5	-0.0	1.6
Medication: Paracetamol	0.6	0.9	2.3	1.5	-1.2	-0.4	0.2	0.6
Risk taking	0.6	0.9	1.9	-0.8	-0.1	-1.2	-0.6	-1.4
Ever depressed for a whole week	0.6	0.7	1.5	-0.5	-0.6	-1.2	-1.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	1.2	0.9	0.9	0.7	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.0	-1.7	-1.0	-1.1	-1.4	-0.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.5	0.1	-0.8	-0.8	-1.1
Ovarian Cancer	0.5	0.7	1.8	-0.0	1.3	-0.2	0.4	-1.1
Lupus	0.5	0.7	2.4	-0.3	1.6	0.5	0.7	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.7	-1.3	-0.7	-0.4	-0.1	-0.5
Respiratory disease	0.5	1.2	3.6	-1.9	-1.2	-0.7	-0.5	-0.1
Number of treatments/medications taken	0.5	0.8	2.0	1.4	-0.9	0.7	0.5	0.9
Supplements: Zinc	0.5	0.5	1.6	-0.6	1.2	0.2	-0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.3	-1.3	-1.5	-0.9	0.5	0.5
Qualifications: CSEs or equivalent	0.5	0.6	1.6	0.6	-0.7	-1.3	-0.8	-0.1
Depression (self-reported)	0.5	0.6	1.6	-0.9	-0.6	-1.3	-0.6	-0.4
Exposure to tobacco smoke at home	0.5	0.6	2.1	0.1	-0.9	0.0	-0.1	1.5
Pulse wave reflection index	0.5	0.7	1.5	0.7	-0.5	1.1	0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	-0.5	-0.4	-0.8	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.6	-0.6	-1.2	-1.3	-0.5	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	2.1	-0.2	-1.4	-0.8	0.2	1.1
Diabetes diagnosed by doctor	0.5	0.8	2.9	-0.5	-0.2	-0.6	-0.6	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	0.4	-1.3	-0.7	-0.7	0.2
Medication: Bendroflumethiazide	0.5	0.8	1.2	-0.9	-1.1	-0.8	-0.0	-1.1
Breast Cancer	0.4	0.9	2.8	-0.0	-0.2	-1.2	0.2	-1.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.5	-0.5	-1.2	-0.7	-0.3	-0.5
Mean Putamen Volume	0.4	0.5	2.0	1.4	0.1	0.4	0.3	0.5
Blood Eosinophil Count	0.4	2.9	9.7	0.9	1.5	1.3	3.1	0.4
Hand grip strength (left)	0.4	1.0	3.7	0.2	-1.9	-1.2	0.3	0.0
Pack years adult smoking proportion	0.4	0.6	1.3	0.4	-0.1	-1.1	-1.1	-0.5
Hand grip strength (right)	0.4	1.0	3.5	0.5	-1.9	-1.2	-0.0	0.3
Medication: Levothyroxine sodium	0.4	0.7	2.5	1.6	0.9	0.5	-0.1	-0.5
Impedance of leg (left)	0.4	2.0	5.1	1.0	-0.2	1.6	1.1	2.2
Diabetes (self-reported)	0.4	0.6	2.8	-0.4	0.5	0.2	0.2	-1.7
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.4	-1.1	-0.5	-0.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	-1.6	-1.3	-1.0	-1.1	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.9	-0.5	-1.0	-0.3	-1.1
Illnesses of mother	0.4	0.5	1.5	-0.1	0.1	1.2	0.4	0.9
Birth weight of first child	0.4	0.8	3.0	0.1	-1.7	-0.0	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	1.2	1.4	0.4	-0.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.0	-1.4	-0.1	-0.3	-0.2	0.4
Pulse wave peak to peak time	0.4	0.5	1.5	0.6	0.6	0.5	1.2	-0.4
Medication: Allopurinol	0.4	0.6	1.4	1.1	-0.6	0.1	-0.0	1.2
Mean time to correctly identify matches	0.4	0.7	1.8	-0.7	0.5	0.6	1.3	-0.8
Smoking status: Previous	0.4	0.6	1.0	0.3	-1.0	0.9	0.7	0.6
Mood swings	0.4	0.7	2.1	0.5	-0.7	-1.5	-0.2	-0.9
Commuting to job workplace: Public transport	0.4	0.5	1.4	0.6	0.8	1.2	0.3	0.1
High cholesterol (Self-reported)	0.4	0.8	1.7	1.3	0.5	0.8	0.5	1.0
Myopia	0.4	0.6	1.5	-1.1	1.2	0.5	0.1	0.1
Pack years of smoking	0.4	0.5	1.3	0.2	-0.0	-0.9	-1.1	-0.6
Crohns Disease (2017)	0.3	0.6	1.2	0.7	0.5	1.0	0.2	-1.1
Irritable Bowel Disease (IBD)	0.3	0.8	3.7	-0.2	0.1	-0.1	-0.3	-1.9
Ulcerative Colitis (UC)	0.3	0.5	2.1	-0.4	-0.1	-0.4	-0.3	-1.4
HbA1C	0.3	0.3	0.8	0.1	-0.9	-0.3	-0.7	0.2
LDL Cholesterol	0.3	0.5	0.9	0.7	-0.8	0.4	0.6	0.9
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.8	-0.6	-0.6	-0.3	-0.9
Blood Red Count	0.3	2.6	5.0	-1.6	-0.5	-0.0	2.2	-2.2
Blood White Count	0.3	2.5	7.4	1.6	-1.3	-0.8	0.7	2.7
Heel T-Score	0.3	2.6	6.8	0.7	-2.6	-1.6	1.5	1.0
Waist Hip Ratio (WHR)	0.3	1.4	5.5	-1.1	0.7	-0.2	0.0	-2.3
Neuroticism	0.3	0.6	2.1	0.2	-1.5	-0.8	-0.3	-0.3
Sensitivity / hurt feelings	0.3	0.5	1.1	0.2	-1.0	0.2	1.0	-0.6
Impedance of leg (right)	0.3	1.6	3.3	0.9	0.5	1.7	1.1	1.8
Supplements: Glucosamine	0.3	0.3	1.3	0.0	-0.2	0.1	0.6	1.1
Past tobacco smoking	0.3	0.6	2.3	-0.1	1.5	-0.5	-0.2	-0.7
Fluid intelligence score	0.3	0.5	1.4	0.9	0.1	1.2	0.5	0.4
Neuroticism score	0.3	0.7	2.6	0.8	-1.6	-0.0	-0.1	0.4
Time employed in main current job	0.3	0.3	0.8	0.2	-0.1	0.9	0.2	0.8
Lung cancer (father)	0.3	0.3	1.3	0.0	-0.4	-1.1	0.5	0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.5	-0.5	-0.3	-0.9	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.6	-0.0	-1.1	-0.4	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	-0.0	0.6	-0.8	0.2	-0.8
Pulse rate, automated reading	0.3	1.0	2.3	-0.7	-0.9	-0.8	-1.5	-0.9
Medication: Blood pressure	0.3	0.5	1.4	0.0	-1.2	-0.4	1.0	-0.1
Medication: Lisinopril	0.3	0.3	1.5	0.2	-0.1	-0.3	-0.2	1.2
Medication: Atorvastatin	0.3	0.4	0.5	-0.7	0.4	-0.6	-0.7	-0.6
Ever smoked	0.3	0.6	1.3	0.7	-0.6	1.1	0.7	0.3
Age started oral contraceptive pill	0.3	0.4	0.7	0.5	0.7	0.9	0.7	-0.2
Cholesterol lowering medication	0.3	0.5	1.0	0.8	-0.3	0.3	1.0	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.3	-0.8	0.6	-0.5	0.8
Crohns Disease (2012)	0.2	0.4	0.8	-0.2	0.5	0.8	-0.9	0.5
HDL Cholesterol	0.2	0.4	1.4	-0.3	1.2	-0.4	0.5	-0.1
Height	0.2	3.2	13.0	0.2	-3.6	0.5	1.2	1.3
Systolic Blood Pressure	0.2	1.1	2.7	0.7	0.2	1.1	1.6	1.1
Cardiovascular Disease	0.2	0.7	2.0	-0.2	-1.4	-1.1	-0.2	-0.7
Hypothyroidism (self reported)	0.2	0.3	0.8	0.7	0.4	-0.5	-0.9	-0.1
Tanning	0.2	2.1	3.0	-1.7	-1.3	-0.9	1.7	-1.6
Diabetes (mother)	0.2	0.2	0.7	0.0	-0.8	-0.0	-0.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.0	-0.1	0.5	0.6	0.8
Breastfed as a baby	0.2	0.2	0.5	0.2	-0.5	-0.3	0.7	-0.5
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.2	0.6	-0.5	-0.9	-0.2
Birth weight	0.2	0.5	1.6	0.7	-1.3	0.3	-0.5	0.5
Comparative height size at age 10	0.2	0.8	1.6	-1.2	-1.3	-0.8	0.7	0.1
Chest pain or discomfort	0.2	0.3	0.5	-0.3	-0.6	-0.2	-0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.8	-0.7	-0.1	-0.2	-0.1
Supplements: Vitamin C	0.2	0.2	0.6	-0.1	0.5	-0.2	0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.6	-0.3	-0.8	0.2	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.5	0.5	-0.4	-0.2	-0.7
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	-1.0	-0.1	-0.3	0.1	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.0	0.3	-0.5	0.7	0.2
Triglycerides	0.1	0.2	0.5	0.0	-0.4	0.2	0.7	-0.4
Ulcerative Colitis	0.1	0.1	0.3	0.1	0.6	-0.0	0.0	-0.2
Allergy or Eczema	0.1	0.3	1.0	0.2	0.1	0.5	1.0	0.2
High blood pressure	0.1	0.2	0.5	-0.4	-0.1	0.1	0.7	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	-0.2	0.1	0.3	0.9	0.1
Number of incorrect matches in round	0.1	0.2	0.3	-0.0	0.4	0.6	0.6	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.1	0.3	-0.0	0.5	0.0
Standing height	0.1	1.4	5.3	-0.1	-2.3	-0.9	0.8	0.2
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.3	-0.4
Number of children fathered	0.1	0.1	0.5	-0.4	-0.1	-0.0	0.7	0.2
Hypertension (Self-reported)	0.1	0.3	0.8	0.4	-0.0	0.5	0.9	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	0.3	-0.5	-0.0	0.3	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.0	-0.5	-0.5	-0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.2	0.2	0.3	-0.5	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	0.1	0.0	0.0	-0.7	0.4
Fasting Glucose	0.0	0.1	0.1	-0.1	-0.3	0.3	-0.0	-0.3
Hair Pigment	0.0	0.9	3.2	-1.1	0.2	-0.1	-0.2	-1.8
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.3	-0.5	-0.4	0.2	-0.3

Hub : Genes

SIKE1

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Trait associations