TWAS hub - SIPA1L3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2533	0.0876	7.6e-03	0.135	NA	0.097	NA	0.103	1.5e-05	NA	2.5e-04	NA	1.6e-04
2	GTEx	Cells Transformed fibroblasts	0.0560	0.0310	8.6e-03	0.000	NA	0.002	NA	0.004	3.3e-01	NA	2.3e-01	NA	1.4e-01
3	GTEx	Heart Atrial Appendage	0.2820	0.0850	3.1e-04	0.147	NA	0.120	NA	0.111	4.1e-07	NA	4.8e-06	NA	1.1e-05
4	GTEx	Heart Left Ventricle	0.2752	0.0643	2.6e-07	0.242	NA	0.250	NA	0.253	4.1e-13	NA	1.4e-13	NA	9.4e-14
5	GTEx	Liver	0.2330	0.0900	5.3e-03	0.123	NA	0.130	NA	0.116	2.7e-04	NA	1.8e-04	NA	3.9e-04
6	GTEx	Pancreas	0.1960	0.0740	4.0e-03	-0.002	NA	-0.005	NA	0.005	4.2e-01	NA	6.4e-01	NA	1.8e-01
7	GTEx	Prostate	0.2270	0.0850	2.9e-04	0.246	NA	0.123	NA	0.183	7.2e-07	NA	5.6e-04	NA	2.3e-05
8	GTEx	Testis	0.1890	0.0710	3.8e-04	0.075	NA	0.132	NA	0.131	3.3e-04	NA	1.8e-06	NA	2.1e-06
9	TCGA	Brain Lower Grade Glioma	0.0327	0.0171	5.1e-03	0.001	0.018	-0.001	NA	0.001	2.5e-01	3.7e-03	4.5e-01	NA	2.7e-01
10	TCGA	Prostate Adenocarcinoma	0.1174	0.0359	2.8e-09	0.076	0.088	0.082	NA	0.082	2.1e-08	1.6e-09	6.7e-09	NA	5.8e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Supplements: Glucosamine	4.2	5.4	17.8	4.0	-1.4	2.7	4.2	1.5	-1.5	0.6	-0.9	1.5	1.7
Medication: Cholesterol lowering	3.3	5.1	13.5	-2.7	2.9	-0.8	-2.3	-1.5	0.0	-2.6	1.2	-2.3	-3.7
Mineral and other dietary supplements	3.3	4.4	11.2	-3.3	1.9	-2.0	-3.1	-1.2	1.0	-1.4	0.8	-2.2	-2.5
Lupus	3.1	4.7	8.3	-2.0	1.8	-1.7	-1.7	-2.4	0.5	-2.5	2.8	-2.9	-2.3
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	14.4	3.8	-1.2	3.5	3.6	0.6	-0.5	0.6	0.6	2.4	1.6
Medication: Ramipril	3.0	3.9	12.8	-2.4	2.1	-1.6	-1.7	-0.7	0.5	-2.0	-0.7	-3.6	-2.2
Prostate Cancer	2.9	4.1	9.9	2.9	-3.1	-0.4	-0.4	-1.3	1.1	2.5	0.1	2.5	2.8
Noisy workplace	2.9	3.6	9.9	-3.1	-0.1	-2.6	-2.9	-2.5	-0.8	0.1	0.2	-2.0	-0.2
Illnesses of father: None of the above (group 1)	2.9	3.6	7.6	2.4	-1.8	2.2	2.1	1.7	-0.5	1.8	-1.3	2.8	1.6
Pain all over the body in last month	2.8	3.0	8.6	-1.7	1.1	-1.7	-2.5	-1.8	0.8	-1.3	2.9	-1.4	-0.7
Ovarian Cancer	2.6	3.5	10.4	0.9	-1.0	1.2	0.0	2.2	2.3	2.2	-3.2	1.8	1.6
Qualifications: A levels/AS levels or equivalent	2.6	5.8	17.8	4.2	-1.8	3.0	3.1	1.7	-0.7	1.3	0.2	3.0	2.0
Medication for cholesterol, blood pressure or diabetes	2.6	4.2	11.2	2.3	-3.0	0.8	1.8	0.5	-1.1	2.6	0.1	2.4	3.3
Migraine (self-reported)	2.6	3.2	8.7	0.8	0.3	2.9	1.5	3.0	1.1	0.7	-2.7	1.7	-0.0
Number of incorrect matches in round	2.4	4.0	14.6	2.6	0.4	3.8	2.2	2.0	0.0	0.5	-1.7	2.4	0.9
Vascular/heart problems diagnosed by doctor	2.4	6.4	19.0	1.9	-4.0	0.3	1.3	0.5	-1.5	4.0	-0.4	2.3	4.4
Mean time to correctly identify matches	2.3	4.4	7.7	-1.8	1.2	-2.8	-2.7	-2.1	-2.2	-1.6	2.5	-2.4	-0.3
Chronotype (morning person)	2.2	5.1	10.7	-3.3	1.2	-2.6	-3.3	-1.6	2.6	-0.4	-0.3	-2.9	-1.9
Shortness of breath walking on level ground	2.2	2.6	8.9	-2.0	-3.0	-1.7	-0.6	-1.3	-0.9	2.1	0.1	-1.0	1.5
Supplements: Fish oil (including cod liver oil)	2.2	2.8	6.2	2.5	-1.8	1.0	2.4	-0.3	-1.6	0.9	0.1	1.6	2.5
Illnesses of father: High blood pressure	2.2	2.7	6.2	-0.7	1.1	-0.9	-0.8	-2.1	0.8	-2.2	2.5	-2.1	-1.8
Mean Putamen Volume	2.1	2.4	9.0	1.6	1.2	1.2	1.3	0.9	-3.0	-1.6	0.2	1.7	-1.1
Angina	2.1	2.8	6.8	-2.6	0.6	-1.8	-1.4	-1.4	-1.5	-1.2	0.5	-2.3	-2.2
Happiness	2.1	2.6	5.8	-0.9	1.1	-2.0	-1.3	-2.4	0.6	-1.1	2.3	-1.4	-1.9
Knee pain experienced in last month	2.1	3.3	6.9	1.7	-2.6	1.3	1.3	-0.0	-2.2	2.0	-0.8	1.9	2.6
Smoking status: Previous	2.1	3.1	6.2	1.1	0.7	1.7	2.3	2.5	1.9	-0.3	-2.1	2.4	-1.1
Eye problems/disorders: Cataract	2.1	2.4	6.5	-1.5	2.5	0.5	-0.7	2.5	0.4	-1.4	-1.8	0.4	-1.7
Ever smoked	2.1	3.8	11.6	0.7	-0.6	0.4	1.7	3.3	3.4	1.0	-1.6	2.8	-0.2
Systolic Blood Pressure	2.0	10.1	31.6	-2.5	4.8	-0.4	-2.8	0.4	4.1	-3.6	0.3	-1.4	-5.6
Cardiovascular Disease	2.0	6.6	18.8	-2.1	4.2	-0.2	-1.4	-0.1	1.4	-4.0	0.7	-2.2	-4.3
Lung FEV1/FVC ratio	2.0	10.2	20.6	-2.8	3.0	-4.5	-2.5	-1.8	-3.7	-4.1	3.4	-2.8	-2.4
Multivitamins +/- minerals	2.0	2.5	8.3	2.5	-0.7	1.9	2.9	1.8	-0.7	-0.6	0.2	1.3	1.0
Medication: Blood pressure	2.0	3.5	8.0	-1.9	2.6	-0.5	-1.4	-0.2	1.4	-2.4	-0.2	-2.5	-2.8
Angina (self-reported)	2.0	2.7	6.2	-2.5	0.4	-1.8	-1.2	-1.5	-1.6	-1.0	0.4	-2.4	-2.0
Qualifications: nursing, teaching	2.0	3.1	7.6	1.5	-2.5	1.0	1.2	1.0	1.0	2.8	-1.1	2.0	2.2
Average weekly champagne plus white wine intake	2.0	2.7	7.5	1.8	1.4	2.1	2.0	2.7	0.0	-1.2	-0.7	2.0	-0.5
Fractured/broken bones in last 5 years	2.0	2.5	5.7	-1.0	1.2	-1.5	-0.7	-1.4	-1.5	-2.4	2.2	-1.5	-1.7
Bipolar Disorder (2011)	1.9	1.9	5.0	1.5	-2.2	0.4	1.1	-1.0	-1.6	1.1	0.6	1.6	1.4
Blood Platelet Count	1.9	22.3	98.4	-5.5	1.4	-4.7	-3.5	-4.4	-9.9	-2.3	1.3	-4.8	-3.3
Qualifications: None of the above	1.9	4.1	11.7	-3.4	0.0	-2.8	-3.3	0.2	2.2	1.3	-0.7	-1.9	-0.4
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.8	-1.8	1.9	-0.8	-1.9	-0.5	0.7	-1.3	0.3	-2.2	-1.9
Hypertension (Self-reported)	1.9	5.3	13.2	-1.7	3.6	-0.3	-1.1	-1.0	1.8	-3.6	1.1	-2.2	-3.6
Primary Biliary Cirrhosis	1.8	2.6	8.0	-0.0	-0.1	1.0	-0.3	2.7	1.1	1.9	-2.8	2.0	0.4
Hair/balding pattern: Pattern 2	1.8	2.3	4.8	-0.8	1.1	-1.3	-1.2	-2.2	0.1	-1.7	2.0	-2.0	-1.4
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	5.6	-1.7	0.0	-2.4	-1.6	-2.2	0.7	-0.8	2.4	-1.1	-0.2
Eye problems/disorders: None of the above	1.8	2.0	5.5	2.3	-1.0	1.4	1.7	-2.0	-1.6	-0.2	1.5	0.4	0.5
Ever taken oral contraceptive pill	1.8	2.0	5.3	1.1	-0.5	1.5	1.6	1.6	1.1	0.7	-2.3	1.9	0.9
Hearing aid user	1.8	2.0	4.9	-2.2	1.3	-0.8	-2.0	-0.3	1.5	-1.0	0.2	-1.5	-1.8
Depression (Nagel 2018)	1.7	2.5	7.5	2.7	-1.7	1.3	1.6	0.0	0.0	1.1	0.3	2.0	2.3
Alzheimer’s Disease (in mother)	1.7	1.9	10.2	1.1	0.9	0.9	0.4	3.2	1.6	0.3	-1.2	1.4	-0.2
Reaction Time	1.7	3.2	7.2	-1.3	0.9	-2.7	-1.9	-1.5	-2.2	-1.8	2.6	-1.0	-0.2
Medication for hormone replacement therapy	1.7	1.9	5.1	1.2	-1.6	-0.3	0.3	0.6	0.4	2.2	-1.9	0.9	2.3
Medication: Co-codamol	1.7	1.9	6.5	0.2	-2.5	-0.3	0.4	0.0	-0.2	2.4	0.0	2.0	1.7
Average weekly fortified wine intake	1.7	2.0	5.7	-0.9	-2.3	-0.8	-1.4	-1.5	-0.6	2.4	-0.5	0.2	1.8
High blood pressure (mother)	1.7	2.3	7.7	-0.7	1.8	-0.4	-0.3	-1.4	-0.7	-2.8	1.9	-1.3	-2.0
Past tobacco smoking	1.7	3.1	11.6	0.2	-0.5	-0.5	-1.0	-2.8	-3.4	-0.2	2.3	-1.8	1.3
Time employed in main current job	1.7	2.0	8.9	0.3	-0.0	1.0	1.4	1.7	-1.8	0.6	-3.0	1.0	0.1
Intelligence (Savage-Jansen 2018)	1.6	5.0	18.0	2.6	-0.2	0.9	0.9	-2.6	-4.2	-2.1	3.5	-0.3	-0.1
Schizophrenia (2018)	1.6	3.4	13.2	-1.9	-1.3	-3.6	-2.9	-1.6	1.3	1.1	0.5	-1.0	0.5
Coronary Artery Disease (CAD)	1.6	1.9	12.5	0.8	1.0	0.2	0.5	3.5	0.2	-0.5	-0.9	1.4	1.0
Relative age voice broke	1.6	2.5	5.0	0.8	-1.8	2.1	1.7	0.8	-0.1	2.2	-1.6	1.7	1.6
High blood pressure	1.6	4.5	12.0	-1.6	3.4	-0.3	-1.1	-0.5	1.3	-3.5	0.5	-2.0	-3.4
Medication: Lisinopril	1.6	2.1	3.6	1.4	1.8	1.9	0.9	1.4	1.6	-1.5	0.9	1.0	-1.7
Schizophrenia (2014)	1.5	3.4	11.6	-2.2	-1.9	-3.4	-2.4	-1.7	0.6	1.5	1.0	-0.7	0.7
Triglycerides	1.5	2.4	7.1	-1.2	-1.9	-1.2	-1.4	0.8	-0.6	2.7	-1.5	1.5	1.9
Had other major operations	1.5	1.8	6.8	1.9	-0.6	2.6	1.6	1.1	-0.7	0.7	-0.4	1.6	0.1
Medication: Lansoprazole	1.5	1.7	3.8	-0.2	-1.2	1.8	0.1	0.8	1.9	1.4	-2.0	-0.0	1.4
Impedance of arm (left)	1.5	7.1	30.5	-2.5	0.4	-0.2	-1.4	4.0	3.1	2.2	-5.5	0.3	1.2
Birth weight of first child	1.5	2.8	8.6	2.5	-0.9	1.3	1.9	-1.9	-2.9	0.5	1.3	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	5.3	2.3	0.5	1.4	1.8	1.5	1.1	-0.1	-0.5	1.5	0.1
Had major operations	1.5	1.8	3.9	-0.4	0.9	-0.4	0.0	-1.6	-1.8	-2.0	1.8	-1.2	-1.5
Systolic blood pressure, automated reading	1.4	4.0	13.1	-2.1	2.6	-0.5	-2.0	-1.3	1.4	-2.2	0.8	-1.2	-3.6
Had menopause	1.4	1.7	3.9	-0.8	1.2	-2.0	-1.0	-1.5	-1.2	-1.3	1.1	-1.4	-1.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.1	-1.1	0.8	-1.8	-2.0	-0.6	0.7	-0.6	1.4	-1.8	-0.9
Impedance of arm (right)	1.4	6.3	23.7	-2.3	0.8	-0.1	-1.5	3.9	3.5	1.7	-4.9	-0.1	0.8
Breastfed as a baby	1.4	1.7	4.0	1.5	-0.5	2.0	1.5	1.2	-2.0	0.8	-0.7	0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	5.2	1.6	-0.6	1.0	1.6	2.3	0.1	0.1	-1.2	1.5	0.7
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.3	-1.2	-1.6	-2.3	-1.2	-0.0	2.3	1.8	-0.1	-0.3	1.4
Financial situation satisfaction	1.4	1.8	4.7	0.1	1.3	-0.6	-0.4	-1.2	0.3	-2.0	2.2	-1.7	-1.5
Average weekly beer plus cider intake	1.4	2.0	7.8	0.4	-1.9	-0.8	0.5	-2.8	-1.9	0.1	1.4	-0.1	1.5
Risk taking	1.4	2.1	6.6	-0.4	-2.1	-0.0	-0.4	0.3	1.0	2.6	-2.4	-0.6	1.6
Impedance of whole body	1.4	7.2	27.7	-1.8	0.5	0.4	-0.9	4.2	4.1	2.2	-5.3	0.6	0.9
Hand grip strength (left)	1.3	3.4	11.1	3.3	0.4	2.7	2.8	-0.2	0.1	-0.1	0.0	2.5	-0.8
Townsend deprivation index at recruitment	1.3	1.8	6.1	0.8	-2.5	0.3	0.9	-0.4	0.5	2.2	-0.3	1.9	0.9
Chronic bronchitis/emphysema (father)	1.3	1.6	5.0	-2.2	1.4	-0.8	-1.7	0.1	1.9	-0.3	-0.0	-0.9	-0.8
Heart attack	1.3	1.7	3.6	0.2	1.3	1.6	0.6	1.9	1.7	-1.3	-1.6	-0.5	-1.3
Fluid intelligence score	1.3	2.6	5.0	2.2	1.3	2.2	1.9	0.8	-2.2	-2.2	0.8	0.1	-0.7
Pulse rate	1.3	2.1	7.2	-1.3	1.3	-1.8	-1.1	2.4	-0.5	0.0	-2.7	0.5	-0.2
Number of full brothers	1.3	1.7	5.0	1.7	0.3	1.3	1.8	2.2	-0.5	-0.3	-0.9	1.4	0.6
Medication: Atorvastatin	1.3	1.6	7.0	-1.6	1.2	-0.4	-0.9	-0.1	-0.7	-0.9	-1.2	-1.0	-2.6
Bipolar Disorder or Schizophrenia	1.2	3.0	8.1	-1.5	-1.8	-2.8	-2.8	-1.8	0.6	1.6	0.9	-0.6	1.1
Body Mass Index (BMI) (2010)	1.2	1.7	3.7	1.0	-1.8	-0.0	1.3	-0.7	-1.9	1.2	0.6	1.2	1.9
Impedance of leg (right)	1.2	5.9	24.3	-2.0	0.5	-0.3	-1.8	3.1	4.9	1.9	-3.7	-0.1	0.3
Serious illness, injury or assault to yourself	1.2	1.4	5.1	-0.7	-2.3	-0.2	0.1	0.0	-0.7	2.1	-1.1	-0.0	1.5
Gout (self-reported)	1.2	1.6	3.5	-1.0	1.9	0.0	0.1	0.1	-0.5	-1.9	-1.3	-1.7	-1.8
Medication: Gliclazide	1.2	1.4	3.8	0.3	-0.6	1.6	1.4	2.0	0.5	0.6	-1.6	1.1	0.9
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.9	0.4	1.3	1.4	0.6	1.7	1.6	-1.3	-1.3	-0.4	-1.3
Number of treatments/medications taken	1.1	2.0	7.0	0.1	1.5	1.8	0.0	1.4	2.6	-1.5	-1.1	-0.5	-1.3
Vitamin and mineral supplements	1.1	1.5	4.8	-1.8	-0.1	-1.3	-1.8	-2.2	0.0	0.5	0.5	-0.7	-1.0
Diabetes (mother)	1.1	1.4	3.4	1.0	-0.7	1.5	1.8	-0.5	-1.6	0.2	1.2	1.5	-0.5
Impedance of leg (left)	1.1	5.6	25.0	-1.2	0.4	0.1	-1.0	3.3	5.0	1.9	-3.5	0.9	0.6
Worrier / anxious feelings	1.1	2.1	4.2	-1.7	1.9	-1.4	-1.8	1.0	0.7	-1.2	-0.6	-2.0	-1.5
Prospective memory result	1.1	1.4	3.6	-0.8	1.9	1.5	-1.3	1.0	0.4	-0.4	-1.7	-1.2	-0.6
Pulse wave Arterial Stiffness index	1.1	1.3	4.0	-1.6	0.5	-1.1	-1.3	-0.9	-0.8	-0.6	0.5	-2.0	-1.0
Birth weight	1.1	2.5	7.2	-0.6	1.2	-0.5	0.1	-1.5	-2.3	-1.9	1.7	-1.2	-2.7
Comparative body size at age 10	1.1	3.2	9.7	0.4	0.4	-1.0	0.4	-2.2	-2.7	-2.6	3.1	-0.9	-1.2
Pulse wave peak to peak time	1.1	1.2	4.7	1.5	-0.5	1.1	1.3	0.8	0.9	0.4	-0.3	2.2	0.6
Medication: Seretide 50 evohaler	1.1	1.2	3.0	1.1	-1.7	0.3	0.8	-0.8	-1.5	1.3	-1.1	0.8	1.0
Arm predicted mass (right)	1.1	5.4	19.7	1.7	-0.5	-0.2	1.1	-3.6	-3.2	-1.7	4.4	0.2	-1.8
Pulse rate, automated reading	1.1	3.6	19.3	-2.1	0.8	-1.9	-1.2	2.2	-0.8	0.8	-4.4	0.2	-0.7
Mood swings	1.1	2.0	3.5	-0.5	1.9	-1.4	-1.2	-0.7	1.6	-1.8	1.7	-1.1	-1.5
Arm fat-free mass (left)	1.1	5.4	22.3	1.7	-0.5	-0.2	1.0	-3.6	-2.7	-2.0	4.7	-0.3	-1.8
Irritability	1.1	1.9	6.4	1.6	1.1	1.9	-0.0	1.5	2.5	-0.6	-0.4	0.2	-1.5
Alcohol drinker status: Previous	1.1	1.2	2.9	-1.0	-1.6	-0.2	-0.3	1.1	-0.9	1.6	-0.5	0.8	1.7
Arm predicted mass (left)	1.1	5.8	24.9	1.4	-0.5	-0.6	0.6	-3.9	-2.6	-2.0	5.0	-0.5	-1.9
Crohns Disease (2017)	1.0	2.2	11.9	-0.3	1.6	-0.6	-1.1	0.0	3.4	-0.7	-1.1	-1.5	-1.3
Irritable Bowel Disease (IBD)	1.0	2.4	15.1	-0.3	1.4	0.3	-0.6	0.8	3.9	-0.8	-1.0	-1.6	-1.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.7	-0.2	-0.5	-2.2	-1.1	-1.7	-0.3	-0.0	1.6	-0.3	-0.2
Ulcerative Colitis	1.0	1.5	4.4	1.4	0.2	2.1	0.8	1.9	1.8	-0.2	-0.8	0.5	0.1
Smoking Status	1.0	2.4	10.2	-0.3	0.2	0.7	1.4	2.0	3.2	0.2	-1.7	1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.6	1.9	-1.6	0.6	0.9	-0.3	0.1	0.8	0.8	1.4	1.6
Taking other prescription medications	1.0	1.6	3.1	0.6	1.6	1.5	0.6	1.3	1.6	-1.7	-0.2	-0.1	-1.8
Trunk fat-free mass	1.0	5.5	25.6	1.7	-0.2	-0.2	0.8	-3.5	-2.1	-2.0	5.1	-0.2	-2.2
Depression (self-reported)	1.0	1.2	7.1	-0.2	-1.0	-0.4	-0.4	0.6	2.7	1.2	0.2	0.4	1.2
Trunk predicted mass	1.0	5.5	25.5	1.8	-0.2	-0.1	0.9	-3.4	-2.2	-2.0	5.0	-0.1	-2.2
Pulse wave reflection index	1.0	1.2	4.0	-0.7	-0.2	-0.9	-1.0	-1.7	-0.1	-0.2	1.0	-2.0	1.2
Headache pain in last month	1.0	1.7	5.7	1.1	0.7	2.4	0.7	2.0	0.8	-0.1	-2.1	0.4	0.1
Arm fat-free mass (right)	1.0	5.2	19.8	1.6	-0.5	-0.2	1.0	-3.6	-2.9	-1.8	4.5	0.2	-1.9
Medication: Blood pressure	1.0	1.9	3.8	-1.3	1.9	-0.1	-1.0	-0.2	1.9	-1.9	0.3	-1.5	-1.8
Ever depressed for a whole week	1.0	1.2	4.3	-0.8	0.8	-1.2	-1.6	-1.3	-0.1	-0.4	1.0	-2.1	-0.3
Myopia	1.0	1.4	5.4	0.9	-0.8	1.1	2.1	0.6	-0.0	0.6	-0.5	2.3	0.8
Waist Hip Ratio (WHR)	0.9	4.2	9.5	-1.6	-3.1	-1.9	-1.2	0.3	1.9	3.1	-2.4	-0.3	2.2
Diabetes (father)	0.9	1.1	5.7	-0.2	-0.3	-0.3	-0.9	-1.4	1.0	-0.4	2.4	-1.1	0.4
Hand grip strength (right)	0.9	2.5	7.0	2.6	0.1	2.3	2.2	0.1	0.4	0.2	-0.1	2.5	-1.1
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.7	-0.1	0.9	0.7	0.2	-0.3	-0.6	-1.9	1.5	-0.2	-1.5
Financial difficulties in last 2 years	0.9	1.2	3.5	1.3	-0.7	0.5	0.7	1.4	1.9	0.4	0.0	1.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	-0.7	1.8	0.1	-0.1	0.4	-0.4	-1.7	1.2	0.2	-1.4
Medication: Ibuprofen	0.9	1.1	3.1	0.3	1.7	0.4	0.1	1.1	0.5	-1.8	0.4	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.0	1.0	-1.4	-0.0	1.4	0.8	1.2	1.1	-0.9	1.1	1.0
Chest pain or discomfort	0.9	1.4	7.9	0.8	-0.8	1.3	1.3	-0.5	-2.8	-0.6	0.7	0.1	0.0
Supplements: Vitamin C	0.9	1.0	5.2	-0.1	0.6	0.4	-0.0	2.3	1.4	0.3	-1.5	0.2	0.6
Whole body fat-free mass	0.9	5.2	21.1	1.4	-0.3	-0.4	0.8	-3.4	-2.8	-2.0	4.6	-0.1	-2.0
Whole body water mass	0.9	5.2	21.7	1.3	-0.2	-0.4	0.7	-3.4	-2.7	-2.1	4.7	-0.1	-2.1
Schizophrenia vs Biploar Disorder	0.8	1.0	3.1	-1.0	0.2	-1.8	-0.9	-1.4	-0.1	-0.4	0.2	-1.5	-1.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.3	2.0	0.2	1.0	0.7	-1.0	-2.3	-1.7	2.1	-0.3	0.3
Breast Cancer	0.8	1.9	7.9	-1.3	0.2	-1.2	-1.3	-0.4	1.9	0.4	-1.2	-2.8	0.7
Age at First Birth	0.8	1.1	2.6	-0.4	1.5	0.0	-0.5	-1.0	0.1	-1.5	0.8	-1.4	-1.6
Lung FVC	0.8	3.9	8.4	2.9	-2.2	1.6	2.6	-1.3	-1.4	0.9	1.4	1.4	2.9
Sensitivity / hurt feelings	0.8	1.3	4.1	-1.3	0.4	-1.5	-2.0	-0.6	0.1	-0.2	0.7	-1.9	-0.6
Medication: Simvastatin	0.8	1.2	3.7	-0.8	1.4	0.9	-0.5	-0.8	0.6	-1.5	-0.4	-1.0	-1.9
Alcohol intake versus 10 years previously	0.8	1.1	2.3	1.0	0.9	1.1	0.9	-1.5	-0.3	-1.5	1.5	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	14.2	1.5	0.2	-0.3	1.2	-2.0	-0.9	-2.2	3.8	0.5	-0.5
Illnesses of mother	0.8	1.0	3.1	-0.4	-1.5	-0.9	-1.1	0.0	0.9	1.8	-0.2	-0.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	15.7	1.4	0.1	-0.6	0.9	-1.7	-0.0	-2.0	4.0	0.5	-0.5
Exposure to tobacco smoke outside home	0.8	1.0	4.5	-0.1	-1.7	0.1	0.3	-1.0	-2.1	0.9	-0.2	0.2	1.0
Medication: Allopurinol	0.8	1.0	2.9	-0.4	1.5	0.2	0.3	-0.4	-0.4	-1.6	-0.8	-1.7	-1.2
Overall health rating	0.8	1.8	5.5	-0.8	1.0	-0.7	-0.6	-0.6	-0.5	-2.3	2.3	-1.0	-1.7
Age at last live birth	0.8	1.2	4.2	0.7	0.8	0.7	0.3	1.8	2.0	0.0	-1.0	0.5	1.2
Illnesses of father: Heart disease	0.8	1.1	2.5	-1.6	1.2	-1.2	-0.9	0.7	0.8	-0.9	-0.5	-0.7	-1.5
Leg fat-free mass (right)	0.8	4.2	14.3	1.4	-0.4	-0.1	1.2	-2.7	-3.4	-1.8	3.8	0.6	-1.4
Leg predicted mass (right)	0.8	4.2	13.8	1.4	-0.3	0.0	1.3	-2.6	-3.3	-1.9	3.7	0.6	-1.5
Basal metabolic rate	0.8	4.6	18.6	1.1	-0.5	-0.4	0.6	-3.3	-2.8	-1.8	4.3	-0.1	-1.8
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.3	-1.8	-0.5	-0.8	-1.3	0.1	1.0	1.0	-0.6	-0.9	0.0
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.7	0.6	0.0	1.9	0.7	1.5	1.1	0.1	-1.0	0.5	0.4
Fasting Glucose	0.7	0.9	2.1	1.0	-0.5	1.0	1.2	-0.9	-1.3	0.2	0.7	1.4	-0.0
LDL Cholesterol	0.7	1.0	2.3	-0.9	1.1	-1.2	-1.5	-0.1	0.7	-0.6	1.2	-0.0	-1.5
Leg fat-free mass (left)	0.7	3.9	13.0	0.9	-0.3	-0.4	0.6	-2.8	-3.2	-1.9	3.6	0.1	-1.7
Maternal smoking around birth	0.7	1.0	4.5	0.6	-0.9	1.2	0.5	0.2	0.5	1.4	-2.1	-0.4	0.9
Qualifications: CSEs or equivalent	0.7	1.0	3.3	0.2	-1.0	0.3	0.7	-1.1	-1.7	0.9	-0.0	0.3	1.8
Medication: Atenolol	0.7	0.9	2.4	1.1	1.0	1.6	1.4	0.7	-0.2	-0.6	-0.8	-0.1	-0.6
Medication: Levothyroxine sodium	0.7	1.2	3.1	-0.8	0.8	-1.7	-0.7	-0.8	0.3	-1.5	1.1	-1.8	-0.5
Leg predicted mass (left)	0.7	3.9	13.1	0.7	-0.2	-0.4	0.5	-2.8	-3.2	-1.9	3.6	-0.0	-1.7
Forced vital capacity (FVC)	0.7	2.8	8.6	2.4	-0.6	0.9	2.4	-1.6	-0.3	-1.2	2.9	1.6	-0.1
Illnesses of siblings	0.7	1.0	3.3	1.8	-1.3	0.5	1.0	-0.6	1.0	0.9	0.2	0.1	1.3
Hair/balding pattern: Pattern 3	0.7	1.0	6.9	0.1	-0.6	0.1	0.5	-1.2	-2.6	0.3	0.5	-0.5	0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	4.7	0.9	-0.4	1.8	0.5	1.5	0.1	0.8	-2.2	0.6	0.6
Length of working week for main job	0.7	0.8	3.0	-1.7	-0.6	-1.0	-1.0	-0.1	0.5	0.2	-0.9	-1.0	0.2
Peak expiratory flow (PEF)	0.7	1.6	4.5	0.2	1.2	-0.8	-0.2	-1.4	2.1	-1.9	1.8	-0.0	-1.0
Medication: Amlodipine	0.7	1.0	2.5	-1.6	-0.7	-1.4	-0.8	-1.5	-0.6	-0.2	0.3	-1.0	-0.9
Wheeze or whistling in the chest in last year	0.7	1.2	4.8	-2.2	-0.3	-1.1	-1.3	0.1	0.4	0.7	-1.2	-1.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.0	-0.0	-0.6	-1.2	-0.4	-0.7	1.7	-0.2	1.7	-0.5	0.2
Medication for pain relief, constipation, heartburn	0.7	1.3	2.4	0.2	-1.3	-1.0	-0.5	-1.6	-0.7	1.6	1.1	0.9	1.4
Long-standing illness, disability or infirmity	0.7	1.0	2.6	-1.6	0.8	-1.0	-1.5	-0.0	0.3	-1.2	1.0	-0.6	-1.0
Ever had bowel cancer screening	0.7	0.8	2.7	0.3	-1.4	0.6	0.2	-0.2	-0.6	1.6	-0.7	0.4	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.2	1.2	0.4	1.8	0.8	1.3	-0.5	0.1	-0.4	0.6	0.1
Medication for cholesterol	0.7	1.1	1.7	-1.1	1.1	-1.2	-1.2	-0.4	-0.6	-0.8	1.3	-1.3	-0.9
Osteoporosis (self-reported)	0.7	0.9	3.5	-0.7	-1.2	-0.6	-0.9	-1.9	-0.3	0.2	1.4	0.8	-0.1
Number of self-reported non-cancer illnesses	0.7	1.2	3.6	-0.3	1.7	-0.3	-0.2	1.9	1.3	-1.3	-0.5	0.2	-1.2
Age started oral contraceptive pill	0.7	0.9	1.9	-1.0	-0.7	-0.6	-0.9	-1.2	0.2	0.9	-1.4	-1.0	0.7
Major Depression (MDD)	0.6	0.7	2.1	0.5	-0.7	0.6	0.4	1.1	0.4	1.1	-1.5	0.2	1.1
Crohns Disease (2012)	0.6	1.0	5.7	-0.2	1.2	-0.1	-0.7	0.9	2.4	-0.5	-0.5	0.5	-0.9
Supplements: Zinc	0.6	0.6	4.5	-0.2	0.1	-0.2	-0.0	1.2	2.1	0.0	0.2	0.5	-0.1
Pack years adult smoking proportion	0.6	0.9	3.1	-1.1	0.8	-0.4	-0.8	-0.3	1.4	-1.1	-0.0	-1.8	-0.7
Stomach or abdominal pain in last month	0.6	0.8	2.8	0.6	0.7	1.7	0.4	1.0	1.5	-0.5	-0.2	0.5	-0.5
Body mass index (BMI)	0.6	2.3	11.3	-0.5	-1.2	-0.8	-0.1	-2.4	-3.4	-0.3	1.9	-0.5	0.2
Asthma	0.6	1.2	5.8	-0.2	0.8	-0.3	0.8	-0.7	-2.4	-1.5	0.6	-0.3	-1.2
High blood pressure (siblings)	0.6	0.8	3.0	-1.1	1.3	0.2	-0.4	0.8	-0.3	-1.0	-0.1	0.2	-1.7
Forced vital capacity (FVC), Best measure	0.6	2.1	8.5	2.1	-0.3	0.9	1.7	-0.9	0.4	-1.1	2.9	1.5	-0.1
Health satisfaction	0.6	0.7	4.5	-0.5	-0.8	-0.1	0.6	-0.6	-2.1	0.1	1.0	-0.5	-0.1
Qualifications: College or University degree	0.6	1.8	4.8	2.2	-0.1	1.4	1.8	0.6	0.6	-1.1	1.4	1.7	-1.1
Heart disease (mother)	0.6	0.7	2.5	-1.6	-0.2	-0.9	-1.1	-1.2	0.7	0.4	-0.2	-0.2	0.2
Family relationship satisfaction	0.6	0.8	2.2	-0.8	-1.0	-0.9	-0.7	-1.5	-0.5	1.1	0.8	-0.2	0.6
Leg pain on walking	0.6	0.7	2.9	-0.3	0.5	0.1	0.3	-0.1	-0.3	-1.3	1.7	-1.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.4	-0.5	0.5	-1.5	-0.7	-1.2	-0.9	-0.3	0.7	-1.1	-0.5
Illnesses of siblings: Diabetes	0.6	0.8	3.5	-0.0	-0.2	0.8	0.3	0.9	1.3	0.8	-0.4	1.9	0.4
Average weekly red wine intake	0.6	0.8	3.8	0.2	1.3	-0.1	0.2	0.3	0.7	-1.1	0.9	0.5	-1.9
Friendships satisfaction	0.6	0.8	2.9	-0.4	-0.4	-0.9	-1.0	-1.6	-0.1	0.1	1.7	0.1	-0.2
Breast cancer (self-reported)	0.6	0.7	1.7	-0.1	-1.3	-1.0	0.5	-0.6	0.3	1.3	0.6	0.5	0.9
Smoking status: Current	0.6	0.9	2.1	-1.0	-1.4	0.1	0.4	0.4	1.5	1.3	-1.1	0.8	-0.1
Medication: Paracetamol	0.6	1.0	2.2	-1.3	0.6	-1.1	-0.9	0.5	1.5	-0.5	-1.0	-1.1	-0.9
Pack years of smoking	0.6	0.9	3.2	-1.1	0.8	0.1	-0.7	-0.0	1.6	-1.0	-0.3	-1.8	-0.6
HbA1C	0.5	0.5	1.7	-0.9	0.5	-0.4	-1.3	0.4	-0.0	0.8	-0.6	1.0	0.1
Allergy or Eczema	0.5	1.2	4.9	-0.8	-1.5	-0.9	-0.6	0.7	0.6	2.2	-0.3	0.7	1.4
Neuroticism	0.5	1.2	3.0	0.2	1.6	-0.4	-0.7	1.3	1.7	-0.9	-0.3	-1.0	-1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	1.2	-1.2	0.4	0.6	-0.7	-0.0	0.7	0.5	1.0	1.2
Severe depression (siblings)	0.5	0.6	2.2	0.3	1.4	-0.5	-0.1	-0.5	-0.3	-1.5	0.6	-0.6	-0.7
Current tobacco smoking	0.5	0.8	1.8	-1.0	-1.3	0.1	0.4	0.4	1.2	1.2	-1.1	0.7	-0.3
Age when periods started (menarche)	0.5	1.2	6.0	-1.1	-0.9	-0.0	-0.1	0.6	-0.2	1.3	-2.5	1.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.2	0.1	-1.7	-0.2	0.7	0.1	-0.5	1.8	-0.3	1.8	1.5
Waist circumference	0.5	1.9	5.9	-1.1	-2.4	-1.2	-0.7	-1.8	-2.2	1.1	0.5	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.0	0.1	-1.6	0.1	0.8	0.4	-0.2	2.0	-0.7	1.4	1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.2	-0.7	0.4	-1.5	-1.5	0.1	0.8	0.1	0.7	-0.3	-0.3
Weight	0.5	2.5	7.3	-0.1	-0.9	-0.7	-0.1	-2.6	-2.7	-0.8	2.7	-0.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.8	0.1	-0.4	-0.4	-0.2	-1.2	-1.6	-0.6	1.9	-0.4	-0.1
Falls in the last year	0.5	0.7	1.5	-1.2	-0.9	-0.9	-0.1	-0.9	-1.0	-0.0	1.2	-0.5	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	1.0	1.0	0.8	0.6	0.6	0.3	-1.2	0.7	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.2	0.1	-0.2	-0.6	-0.7	-0.4	1.6	-0.3	1.8	-0.7	-0.2
Loud music exposure frequency	0.5	0.6	1.7	-1.3	0.5	-0.3	-0.0	-0.3	-0.2	-1.1	0.8	-0.1	-1.3
Medication: Paracetamol	0.5	0.9	2.1	-1.3	0.3	-1.0	-0.8	-0.3	1.5	-0.6	-0.2	-1.4	-0.9
Number of children fathered	0.5	0.6	1.9	-0.8	-0.4	-0.2	-0.6	-1.0	-0.6	-0.1	1.4	-1.0	-0.3
Suffer from ‘nerves’	0.5	0.8	3.5	1.9	-0.0	1.1	1.5	0.4	-0.1	-0.4	0.8	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.1	0.8	-0.3	-0.0	0.4	-1.1	-1.4	0.0	-0.2	0.8	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.9	0.2	-0.4	-0.4	-0.1	-1.1	-1.7	0.0	1.2	-0.4	0.1
Commuting to job workplace: Walk	0.5	0.5	2.1	0.7	1.0	-0.1	0.5	0.3	0.3	-0.8	1.4	0.4	-0.8
Asthma (self-reported)	0.5	1.0	6.2	-0.2	0.5	-0.2	0.8	-0.4	-2.5	-1.1	0.3	-0.0	-1.0
Medication: Aspirin	0.5	0.6	2.5	-1.0	0.5	-0.0	-0.1	-0.5	-0.5	-1.2	-0.5	-0.7	-1.6
Wears glasses or contact lenses	0.5	0.6	2.2	-0.0	0.8	0.1	-0.2	-0.6	-0.4	-0.8	1.0	-0.7	-1.5
Commuting to job workplace: Public transport	0.5	0.6	2.0	1.4	0.3	1.0	1.0	0.5	-1.1	-0.3	0.4	0.0	0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.6	0.4	0.3	0.8	0.5	1.1	-0.9	1.0	0.5	-1.0
Commuting to job workplace: Cycle	0.5	0.6	1.5	1.2	-0.9	0.6	1.1	0.5	0.8	0.4	0.2	0.8	0.7
Supplements: Calcium	0.5	0.6	2.7	0.7	0.3	0.7	0.6	0.3	1.6	-0.7	0.9	0.5	-0.1
Bipolar Disorder (2018)	0.4	0.7	1.4	-0.0	-1.2	0.0	-0.9	-0.8	-0.6	1.2	0.8	0.3	1.1
Alzheimer’s Disease (in father)	0.4	0.4	1.8	0.3	0.2	0.1	0.1	-0.2	-0.8	-0.2	-1.0	-1.4	0.4
Blood Eosinophil Count	0.4	2.8	15.4	-0.8	-0.8	-0.0	0.5	-3.9	-2.2	0.2	1.1	0.8	-1.9
Average weekly spirits intake	0.4	0.5	1.5	1.2	-0.4	0.1	0.5	-1.2	-0.6	-0.1	0.7	-0.5	0.3
Relative age of first facial hair	0.4	0.8	2.8	0.5	-0.7	0.9	0.6	0.7	0.6	1.4	-1.7	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.8	-1.2	-1.1	-1.5	-1.0	0.4	0.3	1.7	0.3	0.5	0.6
Alcohol usually taken with meals	0.4	0.7	2.0	1.4	0.5	1.3	1.0	0.5	0.3	-0.3	0.2	1.1	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.6	1.0	-0.6	0.2	0.3	-0.3	1.1	-0.2	1.6	0.9	0.4
Mouth/teeth dental problems	0.4	0.6	2.1	0.5	0.4	0.3	0.7	-0.7	-1.5	-0.6	1.3	-0.0	-0.3
Neuroticism score	0.4	0.9	3.3	0.3	1.0	-0.7	-1.1	0.5	1.8	-0.4	0.5	-0.9	-1.1
Number of live births	0.4	0.6	1.6	0.6	-1.3	0.1	0.0	-0.6	0.2	1.0	-0.2	-0.7	1.2
Exposure to tobacco smoke at home	0.4	0.4	2.0	0.2	0.2	-0.5	0.4	-0.8	-0.3	-0.9	1.4	-0.2	0.0
Blood clot in the leg (DVT)	0.4	0.5	2.6	0.1	-0.4	0.0	-0.2	-0.1	0.4	0.4	-0.9	-0.9	1.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-0.3	0.8	-1.1	-0.2	-0.4	1.2	-1.3	0.5	-1.3	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	-0.3	-0.2	-0.0	-0.2	1.1	1.1	0.7	-1.2	0.1	0.8
Age at first live birth	0.4	0.8	2.3	-0.9	0.9	0.5	-0.6	1.5	1.3	-0.1	-1.1	-0.2	0.5
Medication: Omeprazole	0.4	0.5	1.7	0.6	0.4	1.3	0.4	0.9	-0.2	-0.6	-0.9	0.1	0.2
Alcohol intake frequency.	0.4	0.8	2.2	-0.6	-1.3	1.4	-0.0	0.2	-0.8	1.5	-0.4	1.0	0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.1	-1.4	-0.1	-0.5	-0.7	-0.8	-0.3	-0.4	-0.6	-0.2	0.1
Medication: Aspirin	0.4	0.5	1.7	-1.3	0.0	-0.1	-0.3	-0.6	-0.1	-0.7	-0.8	-0.6	-1.2
Diabetes diagnosed by doctor	0.4	0.7	2.3	-1.1	-0.1	0.9	-0.1	1.4	1.5	0.3	-0.8	-0.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.6	-0.3	0.9	0.2	-0.3	-0.2	1.3	-0.9	-0.1	-0.5	-1.0
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.9	0.1	-0.9	0.9	0.0	-0.3	-0.9	1.1	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.2	0.7	0.1	-0.6	0.4	-1.8	0.3	-1.0	1.8	-0.4	0.0
Guilty feelings	0.4	0.5	2.2	0.1	0.3	-1.4	-1.5	0.2	0.8	0.1	-0.3	-0.6	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.6	-1.3	0.6	-0.6	-0.7	-0.2	0.5	-0.0	0.2	-1.1	-0.4
High cholesterol (Self-reported)	0.4	0.7	2.7	-1.2	1.0	-0.3	-1.0	-0.2	-0.5	-0.4	-0.6	-0.4	-1.6
Alcohol drinker status: Never	0.4	0.4	1.0	-1.0	-0.2	0.6	-1.0	-0.5	-1.0	0.5	0.4	-0.3	-0.6
Unable to work because of sickness or disability	0.4	0.6	2.7	-1.6	-0.7	-1.1	-1.0	0.1	0.5	0.1	0.2	0.0	-0.3
Basal cell carcinoma (self-reported)	0.4	0.5	2.2	-0.9	0.5	-0.0	-0.3	-0.2	-0.6	-1.0	1.5	0.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.3	-0.2	-0.5	-0.2	-0.3	-0.4	0.1	0.4	-0.7	-1.0	1.5
Neuroticism (Nagel 2018)	0.3	0.6	2.1	0.2	1.5	-0.2	-1.1	0.9	1.0	-0.7	-0.3	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	2.2	0.5	0.8	-0.2	-0.4	1.5	0.2	-0.2	-0.8	-0.3	-0.4
Ulcerative Colitis (UC)	0.3	0.5	2.7	0.1	0.3	0.7	0.4	0.5	1.6	-0.5	-0.1	-0.8	-0.5
HDL Cholesterol	0.3	0.4	2.1	-0.3	0.4	-0.4	-0.8	0.3	1.5	0.0	-0.6	-0.1	-0.7
Neuroticism (2016)	0.3	0.4	1.8	0.2	0.3	-0.5	-0.3	0.0	0.8	0.6	-1.3	-0.5	0.2
Rheumatoid Arthritis	0.3	0.5	2.5	-0.5	-0.2	-1.0	-0.5	-0.3	-1.6	-0.3	0.3	-0.5	0.3
Heel T-Score	0.3	2.4	10.7	-0.8	1.0	-1.6	-1.3	-1.6	3.3	-0.7	1.5	-1.0	-1.1
BMI	0.3	1.8	7.1	0.7	-0.8	0.7	0.9	-1.4	-2.7	-0.9	2.1	1.0	-0.1
Respiratory disease	0.3	0.7	4.8	-0.8	-0.3	-0.8	0.0	-0.6	-2.2	-0.2	-0.1	-0.0	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.0	0.5	0.8	-0.3	-0.4	-0.3	1.4	-0.4	0.7	-0.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.0	-1.0	0.1	-0.5	-0.8	-0.0	0.7	0.2	-0.8	-0.7	0.4
Medication: Metformin	0.3	0.4	1.8	-0.6	-0.6	0.6	0.4	0.6	1.3	0.7	-0.6	0.0	0.0
Trunk fat percentage	0.3	1.2	3.2	-1.8	-1.0	-0.6	-1.0	-0.2	-1.7	0.9	-1.5	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	-0.2	0.3	-0.2	-1.1	0.2	1.0	0.0	0.7	0.5	-0.1
Sitting height	0.3	2.2	9.3	0.2	1.9	-0.5	-0.5	-0.4	1.9	-1.8	1.2	-0.4	-3.1
Nervous feelings	0.3	0.5	2.2	1.5	0.6	0.4	0.1	0.8	0.9	-0.1	-0.2	-0.5	-0.6
Allergy	0.3	0.6	1.9	0.7	1.2	0.8	0.0	-0.3	0.7	-1.4	0.1	-0.6	-0.7
Diabetes (self-reported)	0.3	0.4	1.5	-0.7	0.1	0.8	0.4	0.9	1.2	-0.2	-0.5	-0.1	-0.4
Arm fat percentage (right)	0.3	1.1	4.8	-1.6	-0.8	-0.6	-0.7	-0.7	-2.2	0.3	-0.4	-0.7	0.5
Hip circumference	0.3	1.4	7.7	-0.1	-1.0	-0.3	-0.1	-1.6	-2.8	-0.3	1.4	0.0	-0.5
Lung cancer (father)	0.3	0.3	1.0	0.8	-0.0	-0.2	0.5	-0.8	-1.0	-0.3	0.8	0.3	-0.2
Arm fat mass (right)	0.3	1.3	5.6	-0.7	-1.1	-0.8	-0.1	-1.9	-2.4	-0.1	1.3	-0.5	-0.0
Tense / ‘highly strung’	0.3	0.5	3.1	0.4	1.0	-0.0	-0.6	0.6	1.8	-0.2	0.2	-0.2	-0.5
Body fat percentage	0.3	1.1	3.7	-1.9	-0.8	-0.7	-1.2	-0.5	-1.7	0.6	-1.0	-0.6	0.2
Leg fat percentage (right)	0.3	1.0	3.4	-1.8	-0.6	-1.1	-1.5	-1.0	-1.1	0.2	0.2	-0.8	-0.3
Worry too long after embarrassment	0.3	0.5	1.5	1.1	-0.5	-0.5	-0.1	0.8	-0.1	0.9	-0.2	0.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	1.2	0.3	0.8	0.9	0.3	0.5	-0.6	0.5	-0.1	-0.1
Neck or shoulder pain in last month	0.3	0.4	2.2	-0.4	0.7	0.4	0.0	0.5	1.5	-0.3	-0.5	-0.9	-0.2
Leg fat mass (right)	0.3	1.2	4.3	-1.1	-0.5	-0.8	-0.7	-1.6	-2.1	-0.6	1.4	-0.4	-0.7
Comparative height size at age 10	0.3	1.8	8.8	-0.1	0.5	-0.9	-0.7	-1.5	0.9	-1.0	2.0	-0.0	-3.0
Number of full sisters	0.3	0.4	1.3	0.9	-0.3	0.4	0.4	-0.8	-0.2	-0.6	1.1	-0.2	0.4
Arm fat percentage (left)	0.3	1.1	5.5	-1.6	-0.9	-0.6	-0.5	-0.5	-2.4	0.4	-0.6	-0.4	0.6
Loneliness, isolation	0.3	0.4	1.6	-0.1	0.2	-0.9	-1.1	0.2	1.2	0.3	0.6	0.4	0.3
Back pain experienced in last month	0.3	0.4	1.0	0.4	-1.0	-0.9	-0.1	-0.4	-0.4	0.4	0.5	-0.2	1.0
Arm fat mass (left)	0.3	1.3	6.4	-0.7	-1.1	-0.6	-0.1	-1.7	-2.5	-0.1	1.2	-0.2	0.0
Mother’s age at death	0.3	0.3	1.0	-1.0	0.3	-0.0	-0.3	-0.0	-0.3	0.3	-1.0	-1.0	0.3
Medication: Bendroflumethiazide	0.3	0.4	1.8	-0.2	-0.3	0.8	-0.3	-0.8	0.8	0.1	-0.5	-1.4	-0.3
Diastolic blood pressure, automated reading	0.3	1.0	2.8	-0.1	0.9	-0.6	0.3	-0.0	-1.5	-1.4	-0.1	1.1	-1.7
Leg fat mass (left)	0.3	1.1	4.0	-0.6	-0.4	-0.5	-0.4	-1.7	-2.0	-0.8	1.4	-0.2	-0.7
Worry (Nagel 2018)	0.2	0.5	1.4	0.4	0.7	0.2	-0.5	0.8	1.2	-0.5	0.0	-1.2	-0.9
Blood Red Count	0.2	2.2	8.0	-0.7	2.8	0.7	-1.2	2.3	1.1	-1.9	-0.7	0.5	-0.7
Blood White Count	0.2	1.3	3.6	-1.4	-0.8	-1.1	-1.5	-1.9	-0.7	0.0	1.3	-0.9	0.7
Height	0.2	3.8	16.2	0.9	0.9	0.6	-0.1	-1.6	1.6	-1.4	3.5	1.0	-4.0
Hypothyroidism (self reported)	0.2	0.5	1.1	0.2	0.3	-0.4	0.6	-0.9	1.0	-1.1	0.9	-0.8	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.5	-0.6	0.5	0.8	0.3	0.5	1.2	-0.8	0.0	0.1	-0.8
Tanning	0.2	2.5	5.3	1.2	-1.6	1.1	0.8	2.0	0.5	2.3	-1.7	1.2	2.1
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.5	0.2	-0.4	-0.7	0.5	0.8	0.2	-0.9	-0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.3	0.6	-0.3	-1.0	0.5	0.1	-0.3	-0.5	-0.9	-0.2
Trunk fat mass	0.2	0.8	3.8	-1.2	-0.7	-0.6	-0.6	-1.0	-2.0	-0.0	0.1	-0.3	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	1.2	1.0	-0.4	0.1	0.8	-0.0	-0.3	-0.3	1.1	0.4	-0.2
Father’s age at death	0.2	0.3	1.4	0.4	0.1	0.3	-0.1	-0.5	1.2	-0.0	1.1	0.1	-0.2
Standing height	0.2	2.0	8.6	1.1	0.6	0.5	0.6	-0.9	1.4	-1.3	2.1	0.7	-2.9
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.4	1.1	-1.0	-0.3	0.2	0.7	-1.1	0.4	-0.1	-0.9
Glaucoma (self-reported)	0.2	0.2	0.6	0.5	0.8	0.7	-0.4	-0.1	0.6	0.1	-0.5	0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.0	-0.2	0.4	0.6	-0.7	-0.7	0.3	-0.5	-0.3	0.4
Whole body fat mass	0.2	1.0	4.3	-1.2	-0.6	-0.8	-0.7	-1.4	-2.1	-0.2	0.6	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	0.5	0.2	0.3	-0.7	0.2	0.1	0.6	-0.9	0.2	0.1
Leg fat percentage (left)	0.2	0.6	1.5	-1.2	-0.5	-0.7	-1.0	-1.0	-1.1	-0.2	0.4	-0.4	-0.4
Cholesterol lowering medication	0.2	0.3	1.3	-0.2	-0.2	0.2	0.4	-0.1	-0.6	-0.4	-1.2	0.2	-0.8
Heart disease (siblings)	0.2	0.2	1.1	-1.0	-0.4	-0.1	-0.5	-0.4	-0.5	0.0	0.1	-0.3	-0.4
Depressed Affect (Nagel 2018)	0.1	0.2	1.2	0.3	1.1	-0.1	-0.6	0.0	0.5	-0.4	-0.0	0.0	-0.4
Hair Pigment	0.1	4.3	19.4	-2.2	-1.1	-0.8	-1.3	-1.6	4.4	2.6	-1.4	-1.0	1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.8	-0.0	0.2	-0.2	0.3	0.3	0.9	0.1	-0.1	0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.2	-0.1	-0.3	-0.1	0.2	-0.3	-0.0	-0.1	0.0	0.7
Emphysema/chronic bronchitis	0.1	0.2	0.5	-0.6	-0.7	0.0	0.2	0.1	-0.5	0.0	0.2	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	-0.0	0.1	-0.2	-0.0	-0.5	0.9	-0.4	0.2	0.4	-0.7
Number of operations (self-reported)	0.1	0.2	0.5	-0.3	-0.2	-0.1	-0.4	-0.7	-0.3	-0.1	0.5	-0.3	-0.7
Pain experienced in last month	0.1	0.2	1.2	-0.2	-0.3	-1.1	0.4	0.0	-0.5	0.3	-0.3	0.0	-0.1
Fed-up feelings	0.0	0.1	0.3	0.4	0.6	0.1	-0.3	-0.4	0.1	0.1	0.0	-0.2	-0.1
Miserableness	0.0	0.0	0.1	0.1	0.2	-0.3	0.0	-0.2	0.2	0.0	0.1	0.2	-0.1

Hub : Genes

SIPA1L3

Models

Trait associations