TWAS hub - SIRPA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0664	0.0177	1.7e-07	0.024	0.031	0.033	0.033	0.027	1.6e-08	1.6e-10	3.6e-11	4.5e-11	2.3e-09
2	TCGA	Prostate Adenocarcinoma	0.0652	0.0305	9.2e-03	0.017	0.011	0.020	NA	0.036	6.0e-03	2.2e-02	3.2e-03	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Risk taking	7.1	10.4	11.7	3.4	3.0
Wheeze or whistling in the chest in last year	6.0	10.7	13.2	2.9	3.6
Pulse wave peak to peak time	4.6	5.4	6.2	2.5	2.2
Pulse wave Arterial Stiffness index	4.5	5.3	5.8	-2.4	-2.2
Blood Platelet Count	3.8	44.2	82.4	9.1	2.4
Mouth/teeth dental problems: Mouth ulcers	3.4	5.4	7.5	1.8	2.7
Alcohol drinker status: Previous	3.3	3.7	3.9	-2.0	-1.9
Fractured/broken bones in last 5 years	3.1	4.0	5.4	2.3	1.6
Asthma	2.7	5.3	5.4	2.3	2.3
Asthma (self-reported)	2.6	5.1	5.5	2.3	2.2
Length of working week for main job	2.5	2.7	2.9	1.6	1.7
Shortness of breath walking on level ground	2.5	3.0	5.9	0.2	2.4
Financial difficulties in last 2 years	2.4	3.2	5.3	1.1	2.3
Guilty feelings	2.4	3.7	6.1	1.1	2.5
Lupus	2.3	3.4	5.0	-2.2	-1.4
Hayfever, allergic rhinitis or eczema	2.3	4.9	9.0	0.9	3.0
Loud music exposure frequency	2.2	2.4	3.4	1.8	1.2
Bipolar Disorder (2018)	2.1	3.4	4.0	1.7	2.0
Respiratory disease	2.1	4.7	7.7	2.8	1.3
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	4.2	1.1	2.1
Had major operations	2.1	2.4	3.2	1.8	1.3
HbA1C	1.9	2.1	3.1	1.8	1.0
Average weekly spirits intake	1.9	2.3	4.2	0.7	2.0
Commuting to job workplace: Public transport	1.9	2.3	2.4	-1.6	-1.4
Alcohol drinker status: Never	1.9	2.2	4.0	0.7	2.0
Allergy or Eczema	1.8	4.7	8.5	1.0	2.9
Breastfed as a baby	1.8	2.2	4.3	-2.1	-0.3
Ever taken oral contraceptive pill	1.8	2.0	3.7	0.4	-1.9
Coronary Artery Disease (CAD)	1.7	2.0	3.5	-1.9	0.7
Diabetes (mother)	1.7	2.1	3.1	1.1	1.8
Happiness	1.7	2.0	4.1	-2.0	-0.0
Number of incorrect matches in round	1.6	2.7	3.2	1.8	1.4
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	2.5	-1.6	-1.2
Allergy	1.6	3.8	6.7	-0.9	-2.6
Neuroticism score	1.6	3.2	5.3	1.1	2.3
Number of full sisters	1.6	1.9	2.8	-1.7	-1.0
Medication: Bendroflumethiazide	1.6	2.4	3.1	-1.3	-1.8
Irritability	1.5	2.6	4.6	0.8	2.1
Relative age voice broke	1.4	2.1	3.9	-2.0	-0.6
Osteoporosis (self-reported)	1.4	1.8	3.5	-1.9	-0.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	4.5	2.1	1.8
Schizophrenia (2018)	1.3	2.6	4.4	-2.1	-0.9
Reaction Time	1.3	2.5	3.4	1.8	1.2
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.0	1.4	1.3
Nervous feelings	1.3	2.4	4.5	0.6	2.1
Tense / ‘highly strung’	1.3	2.1	4.2	0.0	2.1
Medication: Ibuprofen	1.3	1.5	2.3	-1.5	-0.8
Osteoarthritis (self-reported)	1.3	1.7	3.0	-0.6	-1.7
Pulse wave reflection index	1.2	1.5	2.8	-1.7	-0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.0	-0.9	-1.4
Commuting to job workplace: Walk	1.2	1.3	1.3	-1.2	-1.1
Medication for cholesterol	1.2	1.9	3.7	1.9	0.3
Worry (Nagel 2018)	1.1	2.3	4.2	0.6	2.0
Crohns Disease (2012)	1.1	1.8	2.5	1.0	1.6
Neuroticism	1.1	2.8	3.8	1.3	2.0
Fed-up feelings	1.1	1.9	2.0	1.4	1.4
Medication: Lansoprazole	1.1	1.2	2.2	1.5	-0.5
Health satisfaction	1.1	1.5	1.8	-1.3	1.1
Unable to work because of sickness or disability	1.1	1.4	2.8	1.7	0.3
Bipolar Disorder (2011)	1.0	1.0	1.9	1.4	0.0
Sensitivity / hurt feelings	1.0	1.7	3.5	0.1	1.9
Serious illness, injury or assault to yourself	1.0	1.2	2.3	1.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	1.9	1.4	0.6
Supplements: Vitamin C	1.0	1.2	1.2	-1.1	1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.2	-1.5	-0.4
Financial situation satisfaction	1.0	1.3	2.4	0.3	1.6
Medication: Blood pressure	1.0	2.0	2.7	-1.6	-1.1
Relative age of first facial hair	0.9	1.8	3.0	-1.7	-0.7
Supplements: Zinc	0.9	1.0	1.9	-1.4	0.4
Townsend deprivation index at recruitment	0.9	1.3	1.3	1.1	1.1
Chest pain or discomfort	0.9	1.3	2.5	1.6	0.3
Basal cell carcinoma (self-reported)	0.9	1.1	1.4	-0.9	1.2
Breast Cancer	0.8	2.0	3.5	-0.7	1.9
LDL Cholesterol	0.8	1.3	1.8	1.3	0.8
High blood pressure	0.8	2.3	2.7	-1.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.8	-1.4	0.4
Diabetes (self-reported)	0.8	1.2	1.4	1.0	1.2
Number of live births	0.8	1.1	2.1	-0.1	-1.5
Comparative body size at age 10	0.8	2.3	2.7	-1.4	-1.6
Angina (self-reported)	0.8	1.0	1.3	0.9	1.1
Back pain experienced in last month	0.8	1.2	1.5	1.0	1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.4	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.4	-1.6	-0.9
Number of self-reported non-cancer illnesses	0.8	1.3	2.3	0.6	-1.5
Average weekly champagne plus white wine intake	0.8	1.1	1.6	0.7	1.3
Mother’s age at death	0.8	1.0	1.8	-0.5	-1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	0.3	-1.4
Medication: Atorvastatin	0.8	1.0	2.0	-0.2	1.4
Pain experienced in last month	0.8	1.3	2.5	-0.3	-1.6
Diabetes (father)	0.7	0.9	1.2	-1.1	-0.7
Chronic bronchitis/emphysema (father)	0.7	0.9	1.4	1.2	0.5
Qualifications: None of the above	0.7	1.4	2.8	-1.7	0.2
Mouth/teeth dental problems	0.7	1.1	2.1	-0.3	-1.4
Time employed in main current job	0.7	0.8	1.4	0.6	-1.2
Noisy workplace	0.7	0.9	1.7	1.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.1	-1.1	-0.8
Prospective memory result	0.7	0.9	1.0	0.9	1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.6	0.5	-1.3
Number of children fathered	0.7	0.8	1.5	0.5	1.2
Emphysema/chronic bronchitis	0.7	0.8	1.2	-1.1	-0.6
Migraine (self-reported)	0.7	0.9	1.7	1.3	0.4
Mean time to correctly identify matches	0.7	1.3	2.6	1.6	0.2
Neuroticism (Nagel 2018)	0.6	1.4	2.5	0.5	1.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	0.1	-1.2
Hypothyroidism (self reported)	0.6	1.4	2.6	0.4	1.6
Lung FVC	0.6	2.9	2.9	-1.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	0.0	-1.2
Ever had hysterectomy (womb removed)	0.6	0.6	1.0	1.0	0.5
Angina	0.6	0.9	1.0	1.0	0.8
Taking other prescription medications	0.6	1.0	1.1	0.9	1.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.8	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	3.7	-1.9	-0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	0.9	-0.9	0.9
Exposure to tobacco smoke outside home	0.6	0.9	1.5	-0.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	1.1	0.7
Medication: Omeprazole	0.6	0.7	0.7	-0.8	0.8
Alcohol intake frequency.	0.6	1.5	2.2	-1.5	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.4	1.2	0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	0.9	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-0.4	-1.1
Hypertension (Self-reported)	0.6	1.8	1.8	-1.3	-1.3
Illnesses of siblings: Diabetes	0.6	0.7	1.2	-1.1	0.5
Wears glasses or contact lenses	0.6	0.6	0.9	-0.6	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-1.2	0.1
Myopia	0.6	0.9	1.7	1.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	0.9	-0.7	0.9
Mean Putamen Volume	0.5	0.6	0.8	-0.6	-0.9
Rheumatoid Arthritis	0.5	0.7	1.2	1.1	0.4
BMI	0.5	3.1	4.4	-1.4	-2.1
Cardiovascular Disease	0.5	1.6	2.2	-1.0	-1.5
Hand grip strength (left)	0.5	1.2	1.5	-1.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.6	-0.8	-0.8
Medication: Co-codamol	0.5	0.5	1.1	-0.1	-1.0
Medication: Metformin	0.5	0.7	1.1	0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	1.1	0.2
Qualifications: CSEs or equivalent	0.5	0.6	0.9	0.6	-0.9
Multivitamins +/- minerals	0.5	0.7	1.0	-1.0	-0.6
Hearing difficulty/problems with background noise	0.5	0.8	0.9	-0.8	-0.9
Falls in the last year	0.5	0.6	1.2	1.1	-0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	1.2	-0.1
Pulse rate	0.5	0.9	1.4	-1.2	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.0	1.1
Blood clot in the leg (DVT)	0.5	0.7	0.9	-0.9	-0.7
Medication: Paracetamol	0.5	0.9	1.1	-0.8	-1.0
Medication: Amlodipine	0.5	0.7	1.2	1.1	0.4
Age at first live birth	0.5	1.0	1.4	0.7	1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.5	0.9	1.0	-0.4
Heart disease (mother)	0.5	0.6	0.9	0.9	-0.5
Leg pain on walking	0.5	0.6	1.0	-1.0	0.4
Knee pain experienced in last month	0.5	0.8	1.3	-1.2	-0.5
Medication: Gliclazide	0.5	0.6	0.9	0.5	1.0
Miserableness	0.5	0.9	1.4	-1.2	-0.7
Medication: Lisinopril	0.5	0.6	1.2	-1.1	-0.3
Cholesterol lowering medication	0.5	0.7	1.3	-1.1	-0.3
Supplements: Calcium	0.5	0.6	0.9	-0.5	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.3	-0.9
Crohns Disease (2017)	0.4	1.0	1.0	1.0	0.9
Irritable Bowel Disease (IBD)	0.4	1.0	1.3	0.8	1.1
Schizophrenia (2014)	0.4	0.9	1.7	-0.4	1.3
Number of treatments/medications taken	0.4	0.8	1.2	-1.1	-0.6
Trunk fat percentage	0.4	1.6	2.9	-0.6	-1.7
Hand grip strength (right)	0.4	1.1	1.5	-1.2	-0.8
Age when periods started (menarche)	0.4	0.9	1.9	-0.0	1.4
Supplements: Glucosamine	0.4	0.5	0.8	0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.0	1.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.7	-0.9
Arm fat mass (right)	0.4	1.5	2.1	-0.9	-1.5
Peak expiratory flow (PEF)	0.4	1.0	1.3	-0.8	-1.2
Birth weight	0.4	0.8	0.9	-0.9	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.3	2.4	-1.6	-0.5
Worry too long after embarrassment	0.4	0.7	1.4	0.1	1.2
Medication: Allopurinol	0.4	0.5	0.7	-0.8	0.7
Age at last live birth	0.4	0.6	0.7	0.8	0.7
Mineral and other dietary supplements	0.4	0.6	0.6	0.8	0.7
Hearing aid user	0.4	0.5	0.8	0.4	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.7	-0.7	-0.9
Leg fat percentage (left)	0.4	1.6	2.5	-0.8	-1.6
Age started oral contraceptive pill	0.4	0.5	0.7	-0.6	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.3	-1.1	-0.5
Triglycerides	0.3	0.5	0.9	1.0	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	0.8	0.3
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.3	-1.0
Medication for hormone replacement therapy	0.3	0.3	0.4	0.5	0.6
Severe depression (siblings)	0.3	0.3	0.4	0.5	0.6
High blood pressure (mother)	0.3	0.5	0.9	0.2	-0.9
Trunk fat mass	0.3	1.3	2.3	-0.5	-1.5
Waist circumference	0.3	0.9	1.2	-1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	0.8	0.9	0.8
Pain all over the body in last month	0.3	0.3	0.5	-0.7	0.3
Arm fat percentage (right)	0.3	1.2	2.1	-0.6	-1.5
Hip circumference	0.3	1.1	1.6	-0.8	-1.3
Father’s age at death	0.3	0.4	0.7	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.8	-1.3	-0.3
Lung cancer (father)	0.3	0.3	0.5	0.4	-0.7
Illnesses of mother	0.3	0.4	0.4	-0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.9	0.2
Hair/balding pattern: Pattern 4	0.3	0.7	0.7	0.8	0.8
Birth weight of first child	0.3	0.6	1.2	1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	0.4	0.9
Gout (self-reported)	0.3	0.4	0.7	-0.9	-0.2
Body fat percentage	0.3	1.4	2.4	-0.6	-1.5
Leg fat percentage (right)	0.3	1.0	1.4	-0.8	-1.2
Neck or shoulder pain in last month	0.3	0.5	1.0	-0.0	1.0
Whole body fat mass	0.3	1.3	2.1	-0.7	-1.5
Family relationship satisfaction	0.3	0.4	0.8	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.8	-0.9	0.7
Arm fat percentage (left)	0.3	1.0	1.8	-0.5	-1.3
Average weekly red wine intake	0.3	0.4	0.7	0.8	-0.4
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.2	-0.9
Qualifications: nursing, teaching	0.3	0.4	0.5	-0.7	-0.6
Arm fat mass (left)	0.3	1.1	1.8	-0.6	-1.3
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.8	-0.1
Number of operations (self-reported)	0.3	0.5	0.5	0.7	0.7
Ever depressed for a whole week	0.3	0.4	0.7	-0.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.8	-0.4
Heart disease (siblings)	0.3	0.3	0.6	0.2	0.8
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.1	0.8
Prostate Cancer	0.2	0.2	0.3	0.4	-0.5
Age at First Birth	0.2	0.2	0.5	-0.1	0.7
Fasting Glucose	0.2	0.3	0.4	-0.6	-0.4
HDL Cholesterol	0.2	0.4	0.6	0.8	0.5
Ulcerative Colitis	0.2	0.4	0.5	-0.7	0.5
Blood Eosinophil Count	0.2	1.5	2.2	0.9	-1.5
Blood Red Count	0.2	1.6	3.1	-1.8	-0.3
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-1.2	0.1
Tanning	0.2	1.9	2.5	-1.6	-1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.1	-0.6
Vitamin and mineral supplements	0.2	0.2	0.4	0.6	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	-0.4
Body mass index (BMI)	0.2	1.1	1.4	-0.8	-1.2
Medication: Simvastatin	0.2	0.4	0.4	-0.7	-0.5
Illnesses of siblings	0.2	0.4	0.6	-0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	0.4	-0.6
Glaucoma (self-reported)	0.2	0.2	0.4	0.0	0.6
High blood pressure (siblings)	0.2	0.3	0.5	0.3	-0.7
Number of full brothers	0.2	0.2	0.3	-0.5	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.7	0.1
Leg fat mass (right)	0.2	0.7	1.2	-0.5	-1.1
Pulse rate, automated reading	0.2	0.6	1.1	-0.3	1.0
Medication: Aspirin	0.2	0.2	0.4	0.6	0.4
Smoking status: Previous	0.2	0.3	0.5	0.0	-0.7
Mood swings	0.2	0.4	0.5	-0.6	-0.7
Ever had bowel cancer screening	0.2	0.2	0.5	0.0	-0.7
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.1	-0.8
Medication: Paracetamol	0.2	0.3	0.4	-0.4	-0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.3	-1.1	0.1
Leg fat mass (left)	0.2	0.9	1.4	-0.6	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	-0.5	0.5
Depression (Nagel 2018)	0.1	0.1	0.2	-0.5	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.7	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	-0.4
Alzheimer’s Disease (in mother)	0.1	0.2	0.2	-0.3	-0.5
Neuroticism (2016)	0.1	0.1	0.1	0.4	0.2
Blood White Count	0.1	0.7	1.5	1.2	0.1
Heel T-Score	0.1	0.9	1.3	-1.1	0.7
Height	0.1	1.6	2.4	-1.6	-0.9
Hair Pigment	0.1	1.6	1.7	1.2	-1.3
Systolic blood pressure, automated reading	0.1	0.3	0.4	-0.7	0.4
Average weekly fortified wine intake	0.1	0.2	0.2	-0.4	-0.4
Maternal smoking around birth	0.1	0.2	0.4	0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.3	0.5	0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.2	0.4
Sitting height	0.1	1.0	1.6	-1.3	-0.6
Past tobacco smoking	0.1	0.3	0.3	-0.5	0.5
Alcohol usually taken with meals	0.1	0.1	0.2	-0.4	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	-0.4
Had other major operations	0.1	0.1	0.1	0.3	-0.3
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.8	-0.1
Heart attack	0.1	0.1	0.1	-0.3	0.3
Fluid intelligence score	0.1	0.2	0.4	-0.6	-0.2
Weight	0.1	0.7	0.8	-0.8	-0.9
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.1	0.4	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	-0.1
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.4	0.0
Medication: Blood pressure	0.1	0.1	0.3	0.1	-0.5
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.3
Overall health rating	0.1	0.2	0.2	-0.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.5	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.3	0.1	0.5
Loneliness, isolation	0.1	0.1	0.1	0.4	-0.1
Friendships satisfaction	0.1	0.1	0.3	0.0	0.5
Medication: Aspirin	0.1	0.2	0.3	0.6	0.2
Ever smoked	0.1	0.2	0.2	-0.5	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.1	0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.3	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.3	0.2
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.1	-0.4
Major Depression (MDD)	0.0	0.1	0.1	0.2	0.2
Ovarian Cancer	0.0	0.1	0.1	0.3	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	0.2
Systolic Blood Pressure	0.0	0.1	0.3	0.1	0.5
Smoking Status	0.0	0.1	0.2	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.2	0.3
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.7	0.1
Chronotype (morning person)	0.0	0.1	0.1	0.0	-0.3
Pack years adult smoking proportion	0.0	0.0	0.0	0.1	0.2
Impedance of leg (right)	0.0	0.1	0.1	-0.4	0.2
Leg fat-free mass (left)	0.0	0.1	0.1	-0.4	-0.3
Current tobacco smoking	0.0	0.0	0.0	0.1	0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.2	-0.1
Medication: Atenolol	0.0	0.1	0.1	0.3	0.1
Impedance of leg (left)	0.0	0.0	0.0	-0.1	-0.1
Leg predicted mass (left)	0.0	0.2	0.2	-0.4	-0.5
Had menopause	0.0	0.0	0.0	-0.2	0.2
Medication: Ramipril	0.0	0.0	0.0	-0.0	-0.2
Impedance of arm (right)	0.0	0.2	0.4	-0.7	-0.1
Trunk fat-free mass	0.0	0.1	0.1	-0.3	-0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.2	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	-0.1
Depression (self-reported)	0.0	0.0	0.0	-0.0	0.1
Impedance of arm (left)	0.0	0.1	0.2	-0.2	0.4
Trunk predicted mass	0.0	0.1	0.1	-0.3	-0.2
Standing height	0.0	0.1	0.1	-0.3	0.0
Headache pain in last month	0.0	0.1	0.1	-0.0	0.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.0	-0.0
Arm fat-free mass (right)	0.0	0.1	0.2	0.3	-0.4
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.1	-0.2
Arm predicted mass (right)	0.0	0.1	0.3	0.1	-0.5
Comparative height size at age 10	0.0	0.0	0.1	0.1	-0.3
Whole body fat-free mass	0.0	0.1	0.1	-0.2	-0.3
Leg fat-free mass (right)	0.0	0.2	0.2	-0.3	-0.5
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.1	0.1	0.2	0.3
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.1	0.1
Breast cancer (self-reported)	0.0	0.1	0.1	-0.3	0.1
Smoking status: Current	0.0	0.0	0.0	0.0	-0.0
Whole body water mass	0.0	0.1	0.1	-0.2	-0.3
Leg predicted mass (right)	0.0	0.1	0.2	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.3	-0.0
Basal metabolic rate	0.0	0.2	0.3	-0.4	-0.5
Arm fat-free mass (left)	0.0	0.3	0.5	-0.1	-0.7
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.1	0.3
Pack years of smoking	0.0	0.0	0.0	0.0	0.2
Impedance of whole body	0.0	0.0	0.1	-0.3	0.0
Arm predicted mass (left)	0.0	0.2	0.4	-0.2	-0.6

Hub : Genes

SIRPA

Models

Trait associations