Hub : Genes

SKOR1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0640 0.032 2.7e-03 -0.002 0.007 -0.001 0.011 -0.001 8.6e-01 4.0e-02 5.6e-01 1.5e-02 4.5e-01
2 METSIM Adipose 0.0922 0.035 1.5e-05 0.034 0.029 0.045 0.031 0.031 7.4e-06 2.7e-05 2.6e-07 1.5e-05 1.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.5 -0.7 0.1
Bipolar Disorder or Schizophrenia 0.2 0.6 1.1 1.0 0.4
Depressed Affect (Nagel 2018) 2.6 5.6 11.0 -0.4 -3.3
Depression (Nagel 2018) 4.0 6.0 12.0 -0.3 -3.5
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.1 -0.4 0.2
Neuroticism (Nagel 2018) 2.6 6.2 12.2 -0.5 -3.5
Schizophrenia (2018) 0.9 1.9 3.5 1.9 0.4
Schizophrenia vs Biploar Disorder 0.9 1.1 2.2 1.5 0.4
Worry (Nagel 2018) 2.8 5.9 11.4 0.6 -3.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.2 -0.4
Alzheimer’s Disease (in father) 0.4 0.5 0.6 -0.8 0.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.5 -0.1
Crohns Disease (2017) 0.1 0.1 0.2 0.5 -0.1
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.0 0.2
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.3 0.2
Major Depression (MDD) 0.3 0.3 0.3 0.6 -0.6
Reaction Time 0.5 1.0 1.5 0.6 1.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.8 -1.7 0.2
Breast Cancer 0.7 1.7 2.9 1.7 -0.7
Ovarian Cancer 0.0 0.0 0.0 -0.2 0.2
Prostate Cancer 2.1 3.0 3.5 -1.9 1.6
Age at First Birth 2.2 3.2 5.7 2.4 -0.9
Bipolar Disorder (2011) 1.4 1.3 1.7 -1.3 -1.0
Body Mass Index (BMI) (2010) 4.2 5.7 11.3 -0.4 3.4
Coronary Artery Disease (CAD) 2.7 3.3 3.6 -1.7 1.9
Crohns Disease (2012) 0.2 0.3 0.6 0.8 0.2
Mean Putamen Volume 0.5 0.6 1.0 -1.0 -0.5
Fasting Glucose 0.1 0.1 0.2 -0.4 0.1
HbA1C 1.2 1.3 2.6 0.1 1.6
HDL Cholesterol 1.4 2.4 4.6 0.5 -2.1
LDL Cholesterol 0.1 0.1 0.2 -0.5 -0.1
Lupus 0.9 1.4 1.9 1.4 -0.9
Neuroticism (2016) 1.2 1.8 2.0 -1.4 -1.3
Primary Biliary Cirrhosis 0.2 0.3 0.6 0.0 0.7
Rheumatoid Arthritis 3.1 4.3 8.4 0.4 -2.9
Schizophrenia (2014) 0.8 1.7 2.6 1.6 0.9
Triglycerides 0.2 0.4 0.5 0.5 0.7
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.1 -1.8 0.4
Ulcerative Colitis 0.6 0.9 1.6 -1.3 0.4
Blood Eosinophil Count 1.0 7.3 13.8 3.7 -1.0
Blood Platelet Count 0.0 0.2 0.2 -0.4 0.4
Blood Red Count 0.8 7.5 8.5 2.9 2.5
Blood White Count 0.2 1.7 3.3 -0.1 1.8
Heel T-Score 0.9 7.4 13.9 1.0 -3.7
BMI 2.1 12.4 20.4 -2.1 4.5
Height 0.0 0.1 0.2 0.1 -0.5
Waist Hip Ratio (WHR) 1.2 5.3 10.1 0.8 3.2
Systolic Blood Pressure 0.2 0.8 1.6 -1.3 0.1
Smoking Status 5.2 12.3 24.4 0.5 4.9
Allergy or Eczema 0.4 1.1 1.3 1.2 -1.0
Cardiovascular Disease 2.2 7.1 14.2 -0.3 3.8
Hypothyroidism (self reported) 0.3 0.7 0.7 0.8 -0.8
Respiratory disease 0.4 0.8 1.0 1.0 0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 0.8 -0.3
Lung FEV1/FVC ratio 0.1 0.5 0.9 -0.3 1.0
Lung FVC 2.2 11.3 21.2 -1.2 4.6
Neuroticism 4.9 11.8 23.5 0.4 -4.8
Chronotype (morning person) 0.3 0.8 1.5 0.2 1.2
Hair Pigment 0.0 1.1 1.7 -0.6 1.3
Tanning 0.3 3.6 7.0 2.6 0.5
Hand grip strength (left) 0.2 0.4 0.6 0.5 0.8
Number of treatments/medications taken 0.9 1.7 1.9 -1.4 1.2
Average weekly spirits intake 0.6 0.7 1.4 -0.3 -1.2
Sensitivity / hurt feelings 2.5 4.2 7.2 1.1 -2.7
Frequency of depressed mood in last 2 weeks 1.9 2.7 2.8 -1.7 -1.6
Hearing difficulty/problems: Yes 0.5 0.7 0.8 -0.9 0.8
Relative age of first facial hair 1.0 2.1 4.1 -2.0 0.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.3 0.4 0.6
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.0 -0.6 -1.0
Ever had hysterectomy (womb removed) 5.1 5.8 7.2 -2.1 2.7
Systolic blood pressure, automated reading 0.1 0.2 0.5 0.1 -0.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.0 0.7
Angina 0.4 0.5 0.7 0.8 0.6
Medication for hormone replacement therapy 1.0 1.1 2.2 -0.2 -1.5
Vitamin and mineral supplements 1.1 1.5 2.2 0.8 1.5
Supplements: Zinc 0.5 0.6 1.1 0.1 -1.0
Medication: Co-codamol 1.6 1.8 3.6 0.0 -1.9
Medication: Metformin 0.1 0.1 0.2 0.4 -0.2
Diabetes (father) 1.2 1.5 2.3 -1.5 0.9
Diabetes (mother) 0.6 0.8 1.0 -1.0 -0.7
Severe depression (siblings) 3.5 3.9 4.7 1.8 -2.2
Pack years adult smoking proportion 1.4 2.1 2.6 1.2 -1.6
Impedance of leg (right) 0.0 0.0 0.1 0.2 0.1
Leg fat-free mass (left) 0.1 0.7 1.4 -0.4 1.2
Trunk fat percentage 3.1 12.3 23.3 -1.1 4.8
Hand grip strength (right) 0.4 1.1 2.0 0.4 1.4
Townsend deprivation index at recruitment 4.1 5.8 10.8 -0.9 3.3
Current tobacco smoking 0.7 1.1 1.1 1.0 1.0
Average weekly fortified wine intake 0.3 0.4 0.4 -0.6 -0.6
Maternal smoking around birth 2.8 4.0 5.4 1.6 2.3
Fed-up feelings 0.9 1.7 3.3 0.0 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 1.9 -0.6 -1.4
Relative age voice broke 0.3 0.5 1.0 -1.0 -0.1
Taking other prescription medications 0.1 0.2 0.2 0.4 0.5
Age when periods started (menarche) 3.7 8.9 17.3 0.7 -4.2
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 0.2 0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 3.5 1.6 -1.9
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.1 -0.8 1.8
Qualifications: CSEs or equivalent 0.0 0.0 0.1 -0.2 -0.1
Serious illness, injury or assault to yourself 0.4 0.5 0.9 1.0 -0.2
High blood pressure 3.7 10.2 19.3 -1.1 4.4
Hayfever, allergic rhinitis or eczema 0.6 1.3 1.6 1.3 -1.0
Multivitamins +/- minerals 0.7 0.8 1.7 -0.0 -1.3
Stomach or abdominal pain in last month 2.6 3.3 4.4 2.1 -1.5
Supplements: Glucosamine 0.2 0.2 0.3 -0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -0.3 -1.1
Medication: Atenolol 0.4 0.4 0.9 -0.2 0.9
Medication: Levothyroxine sodium 0.3 0.5 0.8 0.9 -0.5
Sitting height 0.0 0.1 0.2 -0.5 0.2
Chronic bronchitis/emphysema (father) 1.6 1.8 2.8 0.9 1.7
High blood pressure (mother) 4.6 6.5 7.7 -2.8 2.3
Body mass index (BMI) 1.8 7.7 13.3 -1.4 3.6
Impedance of leg (left) 0.0 0.1 0.1 0.4 0.1
Leg predicted mass (left) 0.2 0.9 1.6 -0.4 1.3
Trunk fat mass 2.3 9.9 18.1 -1.3 4.2
Waist circumference 2.2 7.9 15.2 -0.8 3.9
Number of incorrect matches in round 0.5 0.9 1.5 -0.5 1.2
Past tobacco smoking 4.1 7.6 14.4 0.8 -3.8
Alcohol usually taken with meals 0.2 0.3 0.6 -0.8 0.1
Nervous feelings 2.7 5.0 10.0 0.0 -3.2
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.0 0.1 0.0
Hearing difficulty/problems with background noise 0.4 0.7 1.0 -0.7 -1.0
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 0.0 -1.0
Had menopause 0.4 0.6 1.1 1.1 0.1
Had other major operations 0.1 0.1 0.2 0.4 0.3
Forced vital capacity (FVC) 1.0 4.0 7.8 0.5 2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 3.9 2.0 -1.8
Ever unenthusiastic/disinterested for a whole week 2.6 3.1 6.1 -0.4 2.5
Qualifications: None of the above 0.0 0.0 0.1 -0.1 -0.2
Financial difficulties in last 2 years 5.1 6.8 8.0 -2.4 2.8
Mouth/teeth dental problems 0.1 0.1 0.2 -0.1 0.4
Heart attack 2.7 3.4 6.8 -0.2 2.6
Allergy 0.3 0.6 1.2 -1.1 -0.2
Pain all over the body in last month 0.0 0.0 0.0 0.1 -0.2
Diabetes (self-reported) 0.2 0.3 0.5 -0.1 0.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 0.9 -0.3
Medication: Ramipril 2.8 3.6 6.3 1.0 2.5
Medication: Simvastatin 0.5 0.8 1.4 -0.4 1.2
Fluid intelligence score 0.4 0.9 1.7 -1.3 0.2
Illnesses of siblings 2.3 3.2 5.2 1.1 -2.3
Neuroticism score 3.0 6.3 12.5 0.3 -3.5
Weight 0.9 4.6 8.3 -0.9 2.9
Impedance of arm (right) 0.2 1.0 1.9 1.4 -0.0
Arm fat percentage (right) 3.1 12.1 21.7 -1.6 4.7
Trunk fat-free mass 0.0 0.2 0.5 -0.1 -0.7
Hip circumference 1.3 5.6 8.5 -1.6 2.9
Time employed in main current job 0.6 0.7 0.7 -0.9 0.8
Alcohol intake versus 10 years previously 1.3 2.0 3.4 1.9 -0.7
Father’s age at death 0.3 0.5 0.7 -0.8 -0.5
Worrier / anxious feelings 0.6 1.1 2.2 0.0 -1.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 -0.0 -1.2
Falls in the last year 0.7 1.0 1.8 0.4 -1.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.4 -0.4
Number of live births 0.7 0.9 1.9 -1.4 0.1
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 8.6 -0.1 2.9
Pulse rate 0.0 0.1 0.2 -0.4 0.0
Happiness 1.5 1.8 2.6 -1.0 1.6
Noisy workplace 0.2 0.2 0.4 0.0 -0.7
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.6 0.5 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.5 -0.0
Mouth/teeth dental problems: Dentures 0.3 0.5 1.0 -1.0 0.2
Asthma 0.9 1.7 2.0 1.4 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 -0.8 -0.3
Medication: Cholesterol lowering 0.2 0.2 0.3 -0.4 0.5
Depression (self-reported) 0.5 0.6 0.8 -0.7 0.9
Medication: Lansoprazole 0.7 0.8 1.2 -1.1 -0.6
Prospective memory result 1.4 1.7 2.0 1.4 -1.2
Lung cancer (father) 0.2 0.2 0.2 -0.4 -0.4
Illnesses of mother 0.8 1.0 1.8 0.3 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 4.4 0.1 2.1
Pulse wave Arterial Stiffness index 0.4 0.4 0.5 -0.7 0.6
Impedance of arm (left) 0.1 0.6 1.1 1.0 0.5
Arm fat mass (right) 2.1 8.8 14.8 -1.6 3.8
Trunk predicted mass 0.0 0.2 0.5 -0.1 -0.7
Standing height 0.1 1.0 1.1 0.9 -1.1
Length of working week for main job 0.9 1.0 1.1 -1.1 1.0
Exposure to tobacco smoke at home 0.2 0.3 0.5 -0.7 -0.1
Breastfed as a baby 0.5 0.7 1.3 -1.1 0.1
Tense / ‘highly strung’ 0.1 0.1 0.2 -0.4 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 6.2 1.0 2.5
Hair/balding pattern: Pattern 4 1.1 2.8 4.0 -1.2 -2.0
Birth weight of first child 0.9 1.6 2.5 -0.9 1.6
Peak expiratory flow (PEF) 0.5 1.3 2.4 0.4 1.5
Pulse wave reflection index 0.8 1.0 1.7 -0.5 1.3
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.2 0.4 0.4
Loud music exposure frequency 1.2 1.3 2.7 -1.6 0.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 1.7 -1.0 -1.3
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.8 -0.1 -1.3
Blood clot in the leg (DVT) 0.5 0.6 1.2 0.3 -1.1
Medication: Paracetamol 3.5 5.9 10.0 1.3 -3.2
Headache pain in last month 5.6 9.6 19.2 0.1 -4.4
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 3.0 0.9 -1.7
Glaucoma (self-reported) 1.1 1.3 1.7 -0.9 -1.3
Gout (self-reported) 0.3 0.4 0.7 -0.8 0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 0.7 0.8 -0.7
Medication: Amlodipine 0.5 0.7 0.8 -0.8 0.9
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.6 1.2 0.8
Birth weight 0.4 0.8 1.4 0.5 1.2
Chronic bronchitis/emphysema (mother) 2.6 3.1 3.4 1.8 1.7
High blood pressure (siblings) 0.3 0.4 0.5 -0.5 0.7
Forced vital capacity (FVC), Best measure 0.6 2.1 3.4 0.8 1.9
Body fat percentage 3.3 12.9 23.5 -1.5 4.8
Leg fat percentage (right) 3.2 11.5 19.6 -1.8 4.4
Arm fat-free mass (right) 0.0 0.2 0.2 -0.4 0.4
Exposure to tobacco smoke outside home 0.7 1.0 2.0 0.0 -1.4
Comparative body size at age 10 5.9 16.3 27.0 -2.4 5.2
Number of full brothers 0.5 0.6 0.8 -0.9 0.6
Worry too long after embarrassment 1.8 3.0 6.0 -0.2 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 -0.3 1.2
Wheeze or whistling in the chest in last year 1.4 2.5 4.8 2.2 -0.3
Number of children fathered 1.8 2.1 3.2 -0.9 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.5 1.6 0.2
Age at first live birth 0.6 1.0 1.2 1.1 -0.9
Pulse wave peak to peak time 0.3 0.4 0.5 0.7 -0.5
Health satisfaction 1.5 2.0 3.0 -1.0 1.7
Shortness of breath walking on level ground 0.1 0.1 0.1 0.4 -0.1
Qualifications: College or University degree 0.1 0.4 0.8 0.9 0.2
Eye problems/disorders: None of the above 1.5 1.8 3.5 -0.1 1.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 0.6 0.3
Emphysema/chronic bronchitis 0.3 0.4 0.7 -0.8 -0.1
Medication for pain relief, constipation, heartburn 0.1 0.1 0.2 0.1 0.5
Neck or shoulder pain in last month 0.2 0.2 0.4 -0.6 -0.2
Medication: Blood pressure 0.4 0.6 0.7 -0.7 0.8
Angina (self-reported) 0.4 0.6 0.8 0.9 0.6
Migraine (self-reported) 0.1 0.1 0.2 0.2 0.4
Medication: Ibuprofen 1.1 1.3 1.8 -1.3 -0.9
Medication: Allopurinol 0.8 1.1 2.1 -1.5 -0.1
Medication: Omeprazole 0.5 0.6 1.1 -1.1 -0.2
Medication: Seretide 50 evohaler 2.2 2.5 4.6 2.1 -0.7
Mean time to correctly identify matches 0.1 0.3 0.3 0.5 0.5
Heart disease (mother) 0.1 0.1 0.1 0.3 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.0 -1.4 0.5
Whole body fat mass 2.1 9.0 15.7 -1.5 4.0
Leg fat mass (right) 2.9 11.4 18.4 -2.1 4.3
Arm predicted mass (right) 0.0 0.1 0.2 -0.4 0.3
Pulse rate, automated reading 0.1 0.3 0.6 0.8 -0.2
Alcohol intake frequency. 0.2 0.4 0.4 0.6 -0.6
Comparative height size at age 10 0.3 1.4 2.7 0.4 1.6
Number of full sisters 0.0 0.0 0.0 -0.1 0.1
Suffer from ‘nerves’ 3.7 5.8 11.3 -0.6 -3.4
Overall health rating 0.2 0.5 0.6 -0.7 0.8
Chest pain or discomfort 1.2 1.8 1.9 1.4 -1.3
Had major operations 0.5 0.6 0.6 -0.7 0.8
Age at last live birth 0.2 0.3 0.4 -0.4 0.7
Family relationship satisfaction 0.0 0.0 0.0 0.1 0.1
Leg pain on walking 0.1 0.1 0.1 -0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.7 0.8 -0.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.7 -0.8 0.4
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 4.1 0.0 -2.0
Medication: Aspirin 1.1 1.4 2.3 1.5 0.8
Supplements: Vitamin C 1.2 1.4 2.8 -0.1 -1.7
Knee pain experienced in last month 2.0 3.1 4.8 -2.2 1.2
Hypertension (Self-reported) 2.9 8.0 15.3 -0.9 3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.6 -0.8 -0.4
Illnesses of father: Heart disease 0.9 1.2 1.9 1.4 -0.8
Illnesses of siblings: Diabetes 0.9 1.1 1.2 -1.0 1.1
Smoking status: Previous 3.9 5.8 10.1 -1.2 3.2
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.3 6.4 2.5 -1.5
Whole body fat-free mass 0.0 0.0 0.1 -0.2 0.2
Leg fat-free mass (right) 0.1 0.4 0.7 -0.2 0.8
Arm fat percentage (left) 3.1 12.5 22.1 -1.7 4.7
Average weekly red wine intake 3.6 5.3 10.3 -0.5 3.2
Handedness (chirality/laterality): Left-handed 2.5 3.0 5.3 -0.8 -2.3
Mood swings 0.2 0.3 0.6 0.0 -0.8
Loneliness, isolation 0.8 1.1 2.0 -1.4 -0.4
Long-standing illness, disability or infirmity 0.5 0.7 1.1 1.1 -0.6
Ever had bowel cancer screening 1.4 1.7 3.0 1.7 -0.6
Diabetes diagnosed by doctor 0.2 0.3 0.6 -0.0 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 1.2 0.4
Friendships satisfaction 0.1 0.1 0.1 0.3 0.3
Qualifications: nursing, teaching 0.1 0.2 0.3 0.6 0.1
Commuting to job workplace: Walk 0.3 0.3 0.4 0.4 0.6
Eye problems/disorders: Cataract 2.6 3.0 5.8 0.5 -2.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.5 0.3 -1.2
Medication for cholesterol 0.7 1.1 2.2 1.5 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.0 -1.0 0.6
Back pain experienced in last month 1.9 2.7 3.7 -1.3 -1.9
Mineral and other dietary supplements 0.2 0.3 0.4 0.5 0.6
Breast cancer (self-reported) 0.9 1.1 1.1 -1.1 1.0
Asthma (self-reported) 0.7 1.5 1.7 1.1 1.3
Osteoporosis (self-reported) 0.2 0.3 0.5 0.7 0.1
Osteoarthritis (self-reported) 2.4 3.1 6.1 -0.2 2.5
Medication: Aspirin 1.3 1.7 2.5 1.6 0.9
Medication: Gliclazide 0.5 0.6 0.7 0.8 0.7
Illnesses of father: None of the above (group 1) 0.3 0.4 0.6 0.3 -0.8
Smoking status: Current 1.3 2.1 2.9 1.1 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 5.4 10.5 -0.5 3.2
Whole body water mass 0.0 0.1 0.1 -0.3 0.2
Leg predicted mass (right) 0.1 0.3 0.6 -0.2 0.8
Arm fat mass (left) 2.1 8.6 14.7 -1.6 3.8
Number of self-reported non-cancer illnesses 1.3 2.3 4.5 -0.2 2.1
Average weekly champagne plus white wine intake 0.6 0.8 0.9 -0.8 0.9
Miserableness 2.2 3.8 7.4 -0.4 -2.7
Guilty feelings 1.9 2.8 4.6 -1.0 -2.1
Wears glasses or contact lenses 0.5 0.5 1.0 -0.3 -1.0
Ever taken oral contraceptive pill 0.7 0.8 0.9 -0.9 -0.8
Hearing aid user 1.9 2.2 2.7 -1.3 -1.7
Mother’s age at death 0.3 0.4 0.7 -0.1 -0.9
Financial situation satisfaction 0.7 0.9 1.3 -0.7 1.1
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.1 -0.1 -1.8
Commuting to job workplace: Public transport 0.4 0.5 0.8 0.9 0.5
Eye problems/disorders: Glaucoma 1.8 2.2 3.1 -1.1 -1.8
Medication: Blood pressure 3.1 5.9 6.1 -2.4 2.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.6 -0.5 -1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.1 -0.7 -1.1
High cholesterol (Self-reported) 0.2 0.3 0.5 0.5 0.7
Medication: Bendroflumethiazide 4.2 6.4 10.7 -1.5 3.3
Medication: Paracetamol 3.0 4.7 6.7 1.6 -2.6
Medication: Lisinopril 0.8 1.1 2.1 -1.4 0.2
Medication: Atorvastatin 0.4 0.5 1.0 1.0 -0.1
Illnesses of father: High blood pressure 2.3 2.8 5.2 -2.3 0.6
Alcohol drinker status: Never 0.6 0.7 1.1 0.6 -1.0
Ever smoked 1.6 2.8 5.3 -0.6 2.3
Basal metabolic rate 0.1 0.5 0.7 -0.5 0.8
Leg fat percentage (left) 2.9 10.4 18.1 -1.7 4.2
Arm fat-free mass (left) 0.0 0.1 0.2 -0.5 0.1
Number of operations (self-reported) 1.1 1.6 2.6 -0.9 1.6
Average weekly beer plus cider intake 0.1 0.2 0.3 -0.5 0.2
Irritability 1.4 2.3 2.9 -1.7 1.3
Risk taking 0.4 0.6 0.8 -0.6 0.9
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 1.2 0.6
Fractured/broken bones in last 5 years 3.4 4.4 7.1 -1.3 2.7
Age started oral contraceptive pill 1.2 1.5 2.9 -1.7 -0.3
Diastolic blood pressure, automated reading 2.8 8.6 16.2 -1.1 4.0
Ever depressed for a whole week 2.5 3.0 4.7 1.2 2.2
Unable to work because of sickness or disability 0.0 0.0 0.0 -0.2 -0.1
Commuting to job workplace: Cycle 0.2 0.3 0.4 0.4 -0.6
Myopia 0.5 0.7 0.9 0.7 0.9
Vascular/heart problems diagnosed by doctor 4.6 12.6 24.4 0.9 -4.9
Cholesterol lowering medication 0.1 0.1 0.2 -0.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.1 -0.4
Pain experienced in last month 1.6 2.7 3.4 1.4 1.9
Supplements: Calcium 0.0 0.0 0.0 -0.2 0.2
Basal cell carcinoma (self-reported) 0.8 1.0 1.2 0.9 -1.1
Heart attack/myocardial infarction (self-reported) 2.4 3.1 6.1 0.1 2.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 1.9 0.5 -1.4
Heart disease (siblings) 0.0 0.0 0.1 -0.3 0.0
Alcohol drinker status: Previous 0.0 0.1 0.1 0.2 0.2
Pack years of smoking 0.7 1.0 1.6 0.6 -1.2
Impedance of whole body 0.1 0.6 1.0 1.0 0.4
Leg fat mass (left) 2.5 9.9 16.2 -1.9 4.0
Arm predicted mass (left) 0.0 0.1 0.2 -0.5 -0.1