Hub : Genes

SLC15A4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2580	0.0700	5.6e-04	0.168	NA	0.138	NA	0.130	1.4e-09	NA	4.9e-08	NA	1.2e-07
2	GTEx	Cells Transformed fibroblasts	0.2130	0.0620	1.8e-03	0.038	NA	0.047	NA	0.069	6.9e-04	NA	1.9e-04	NA	7.4e-06
3	GTEx	Muscle Skeletal	0.1180	0.0419	7.5e-03	-0.003	NA	-0.002	NA	0.002	7.8e-01	NA	5.1e-01	NA	1.9e-01
4	GTEx	Testis	0.3290	0.0800	2.1e-04	0.143	NA	0.149	NA	0.179	6.6e-07	NA	3.9e-07	NA	2.2e-08
5	NTR	Blood	0.0515	0.0138	2.7e-05	0.019	0.018	0.017	0.023	0.019	8.2e-07	1.3e-06	3.2e-06	4.7e-08	5.5e-07
6	YFS	Blood	0.1033	0.0158	0.0e+00	0.098	0.087	0.107	0.101	0.109	2.4e-30	4.9e-27	5.2e-33	2.2e-31	8.6e-34
7	TCGA	Thyroid Carcinoma	0.0440	0.0200	2.2e-03	0.044	0.023	0.015	NA	0.037	4.0e-05	2.2e-03	1.2e-02	NA	1.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.3	0.3	0.2	0.3	-0.1	0.1	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.5	0.7	0.8	-0.2	0.2	-0.3	-0.0
Depressed Affect (Nagel 2018)	1.0	2.2	4.5	-0.9	-1.5	-2.1	1.8	-0.7	1.6	-1.2
Depression (Nagel 2018)	1.5	2.3	4.2	1.8	2.1	0.0	-1.9	1.2	-1.6	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.6	-0.3	0.4	0.6	-0.6	-0.1	-0.3
Neuroticism (Nagel 2018)	0.6	1.4	2.7	-0.7	-0.9	-1.5	1.4	-0.7	1.6	-1.0
Schizophrenia (2018)	0.1	0.2	0.5	-0.4	0.7	0.7	-0.4	0.3	-0.5	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.7	0.6	0.0	-0.6	0.8	-1.0	1.0
Worry (Nagel 2018)	0.2	0.4	2.0	0.0	-0.1	-1.4	0.3	-0.4	0.6	-0.3
Alzheimer’s Disease (in mother)	0.6	0.7	2.2	1.5	0.1	0.1	-0.7	0.9	-1.0	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.1	0.1	0.8	-0.4	-0.4	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.8	1.7	0.3	0.4	-1.3	0.8	-1.0	0.6
Crohns Disease (2017)	0.4	0.8	1.6	-1.1	0.1	1.3	0.4	-1.0	0.7	-1.0
Irritable Bowel Disease (IBD)	2.0	4.9	8.8	-2.5	-0.9	0.1	1.8	-2.9	2.5	-3.0
Ulcerative Colitis (UC)	2.8	5.2	9.1	-2.4	-1.1	-0.6	2.0	-2.9	2.7	-3.0
Major Depression (MDD)	1.1	1.3	3.3	-1.8	-0.0	-0.3	0.7	-1.3	1.4	-1.4
Reaction Time	0.9	1.8	4.9	0.6	1.0	1.4	-1.4	0.8	-2.2	1.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.4	-0.4	-0.1	-0.1	0.2	-0.4	0.6	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	0.8	0.3	-0.9	-0.8	-0.4	0.7	-0.9	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.4	2.0	3.1	-1.4	-1.5	-0.9	1.8	-0.9	1.6	-1.6
Bipolar Disorder (2011)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	0.0	0.3	-0.8
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	1.0	-0.0	0.8	-0.7	0.3	-1.4	1.2
Coronary Artery Disease (CAD)	0.2	0.2	0.8	0.4	-0.1	0.9	-0.2	-0.6	0.1	0.3
Crohns Disease (2012)	1.6	2.5	4.2	-1.8	-1.5	-0.7	1.3	-1.7	2.1	-1.7
Mean Putamen Volume	0.1	0.1	0.3	-0.1	-0.2	-0.1	0.1	-0.2	-0.5	-0.3
Fasting Glucose	0.2	0.2	0.5	-0.2	0.1	0.3	0.4	-0.7	0.6	-0.7
HbA1C	0.9	1.0	3.1	-1.1	-0.5	0.3	0.8	-1.0	1.0	-1.8
HDL Cholesterol	0.1	0.2	0.5	0.7	0.0	0.1	-0.1	0.5	-0.4	0.4
LDL Cholesterol	1.8	2.8	6.5	-1.0	-1.7	-0.2	2.5	-1.4	2.2	-1.5
Lupus	14.1	21.3	31.4	5.6	5.0	3.9	-5.2	4.5	-3.2	4.7
Neuroticism (2016)	0.3	0.5	1.9	0.5	0.9	1.4	-0.1	0.3	-0.4	0.4
Primary Biliary Cirrhosis	2.5	3.6	7.5	2.6	0.3	0.8	-2.3	1.9	-1.4	2.7
Rheumatoid Arthritis	0.3	0.5	1.3	0.7	-0.8	-1.2	-0.4	0.5	-0.4	0.6
Schizophrenia (2014)	0.3	0.6	1.4	-1.2	-0.7	-1.0	0.8	-0.5	0.3	-0.6
Triglycerides	0.3	0.5	1.2	-1.0	-0.8	0.3	1.1	-0.2	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.0	1.8	0.6	0.1	-1.1	1.6	-2.2	2.1
Ulcerative Colitis	1.6	2.3	4.2	-1.3	-0.8	-0.5	1.5	-1.8	2.1	-2.0
Blood Eosinophil Count	0.0	0.4	1.3	-0.5	0.1	1.1	0.6	-0.4	-0.2	-0.8
Blood Platelet Count	0.1	0.9	2.1	-1.2	-1.4	-1.1	1.2	-0.3	0.1	-0.3
Blood Red Count	0.1	0.9	2.1	-1.0	-0.8	-0.7	0.9	0.5	1.4	-1.1
Blood White Count	0.8	5.6	8.8	-2.7	-1.6	-0.8	2.7	-2.1	2.9	-3.0
Heel T-Score	0.3	2.7	5.1	-2.2	-0.8	-0.9	1.1	-2.2	1.8	-1.8
BMI	0.3	2.0	5.5	2.3	-0.4	0.2	-0.8	1.8	-1.2	1.7
Height	0.1	2.5	4.9	2.1	0.1	-0.6	-1.8	2.2	-1.3	1.9
Waist Hip Ratio (WHR)	0.6	2.5	6.3	-1.4	-2.5	-1.6	1.9	-0.4	1.3	-1.2
Systolic Blood Pressure	0.1	0.3	0.8	0.1	0.4	0.9	-0.6	-0.3	0.8	-0.3
Smoking Status	0.1	0.1	0.5	-0.3	-0.5	-0.3	-0.2	0.0	-0.7	-0.0
Allergy or Eczema	1.4	3.7	5.7	-2.2	-1.4	-1.0	2.4	-1.8	1.9	-2.4
Cardiovascular Disease	0.3	1.0	2.6	1.1	1.2	0.8	-1.6	0.2	-1.0	0.4
Hypothyroidism (self reported)	5.1	11.8	16.3	4.0	3.0	1.2	-4.0	3.3	-3.7	3.8
Respiratory disease	0.1	0.2	0.6	0.6	0.3	0.1	-0.8	0.3	-0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	0.4	0.6	0.3	-0.8	-1.4	-0.9	-0.6
Lung FEV1/FVC ratio	0.8	4.2	6.5	-2.0	-1.1	0.6	2.4	-2.5	2.4	-2.3
Lung FVC	0.1	0.7	1.6	0.6	0.1	-0.4	-0.9	0.8	-1.1	1.2
Neuroticism	0.8	1.9	3.7	-0.8	-1.1	-1.9	1.6	-1.1	1.6	-1.3
Chronotype (morning person)	0.6	1.3	4.5	-0.2	2.1	2.1	-0.4	0.4	-0.1	-0.1
Hair Pigment	0.0	0.2	0.5	-0.7	0.0	0.6	0.5	-0.3	0.6	-0.3
Tanning	0.9	11.1	19.5	3.5	-0.4	-0.4	-2.9	4.4	-4.4	4.2
Hand grip strength (left)	0.2	0.4	2.4	-0.4	0.0	1.5	-0.3	0.6	-0.2	0.3
Number of treatments/medications taken	0.6	1.0	2.5	0.2	-0.5	-1.0	0.6	-1.0	1.6	-1.4
Average weekly spirits intake	1.2	1.5	2.9	1.4	1.0	0.7	-0.9	1.7	-1.1	1.5
Sensitivity / hurt feelings	3.8	6.6	9.8	-2.7	-2.8	-1.6	3.1	-1.6	3.1	-2.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.1	1.0	0.7	-1.5	-1.2	0.9	-1.4	0.7
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.9	1.1	-0.3	-0.7	-0.6	-0.1	0.2
Relative age of first facial hair	0.2	0.4	1.6	-0.2	0.9	1.3	-0.2	0.2	-0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	0.1	0.2	-0.6	0.0	-0.8	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.6	-0.3	1.2	1.3	-0.3	-0.9	0.3	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	1.2	1.1	1.1	-0.8	-0.3	-1.0	0.6
Systolic blood pressure, automated reading	0.1	0.4	1.2	-0.2	-0.1	0.4	-0.2	-0.6	1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.6	-0.4	-0.0	0.7	0.7	-1.6	1.2	-1.1
Angina	0.7	0.9	1.4	-1.1	-0.8	-1.1	0.7	-1.2	0.6	-1.0
Medication for hormone replacement therapy	2.3	2.6	5.9	-1.6	-0.1	0.4	1.4	-2.2	2.4	-1.7
Vitamin and mineral supplements	1.2	1.7	2.8	1.0	1.1	1.7	-1.3	1.0	-1.3	1.5
Supplements: Zinc	0.5	0.6	1.6	-0.5	-0.1	-1.3	0.5	-0.0	1.3	-0.3
Medication: Co-codamol	0.3	0.3	1.2	0.3	-0.7	-0.3	0.2	-0.1	1.1	-0.6
Medication: Metformin	2.0	2.8	4.4	-1.4	-1.8	-1.3	1.7	-2.1	1.6	-1.9
Diabetes (father)	0.1	0.2	0.6	-0.2	-0.7	-0.8	0.1	0.3	-0.1	-0.0
Diabetes (mother)	0.3	0.4	1.1	0.2	-0.4	-0.3	0.7	-0.6	1.0	-0.6
Severe depression (siblings)	0.3	0.3	1.8	-0.2	0.1	-0.2	0.0	-1.3	-0.3	-0.4
Pack years adult smoking proportion	0.2	0.4	0.8	-0.6	-0.1	0.2	0.9	0.1	0.6	-0.9
Impedance of leg (right)	0.0	0.1	0.2	0.0	-0.2	-0.4	0.2	0.1	-0.4	0.1
Leg fat-free mass (left)	0.5	2.8	6.7	1.9	0.4	1.1	-1.5	2.6	-1.5	1.8
Trunk fat percentage	0.0	0.2	0.4	0.6	-0.3	0.3	0.3	0.6	-0.1	0.2
Hand grip strength (right)	0.1	0.2	0.6	-0.1	-0.0	0.7	-0.8	0.6	0.2	0.5
Townsend deprivation index at recruitment	0.2	0.2	0.5	0.4	0.5	-0.3	-0.7	0.3	-0.7	0.1
Current tobacco smoking	0.2	0.3	0.8	0.2	0.7	0.2	-0.9	0.0	-0.6	0.7
Average weekly fortified wine intake	0.4	0.5	1.1	1.1	-0.5	-0.6	0.3	1.0	0.1	0.8
Maternal smoking around birth	0.7	1.0	2.9	0.5	1.7	1.7	-0.5	0.3	0.6	0.2
Fed-up feelings	0.1	0.2	0.6	0.3	-0.8	-0.5	0.2	0.5	-0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	5.4	2.2	2.3	0.9	-1.9	1.7	-2.3	1.2
Relative age voice broke	0.1	0.2	0.7	0.1	0.3	-0.0	-0.5	0.8	-0.3	0.4
Taking other prescription medications	0.8	1.2	2.9	-0.4	-0.5	-1.5	0.8	-1.2	0.8	-1.7
Age when periods started (menarche)	0.2	0.6	1.0	-0.9	1.0	0.6	-0.9	-0.8	-0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.6	-0.6	0.0	0.3	0.9	-1.9	1.1	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.1	0.8	-0.3	-0.6	0.2	-0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	1.0	0.3	-0.0	-0.2	1.1	-1.3	0.9
Qualifications: CSEs or equivalent	0.2	0.2	0.7	0.3	-0.8	-0.2	-0.2	0.3	-0.7	0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.1	-0.9	-0.9	0.6	-0.0	-0.4	-0.2
High blood pressure	0.1	0.2	0.8	0.2	0.9	0.1	-0.8	-0.2	-0.0	-0.5
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.4	-0.8	-1.7	-0.9	1.9	-0.5	0.8	-1.1
Multivitamins +/- minerals	0.9	1.1	1.9	-1.3	-0.2	-0.7	1.2	-1.0	1.1	-1.4
Stomach or abdominal pain in last month	0.2	0.2	0.9	0.3	0.5	0.9	-0.4	0.0	-0.1	0.1
Supplements: Glucosamine	0.7	0.9	1.7	-0.6	-0.7	-1.3	0.9	-1.2	0.9	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	-0.5	-0.9	-0.1	0.6	-0.9	1.5	-0.7
Medication: Atenolol	0.5	0.6	1.7	-0.8	-0.4	1.3	0.4	-0.8	0.4	-1.0
Medication: Levothyroxine sodium	2.7	4.5	6.9	2.6	2.2	0.9	-2.6	1.5	-1.9	2.5
Sitting height	0.2	1.2	3.5	1.1	-0.8	0.1	-0.5	1.9	-0.8	1.4
Chronic bronchitis/emphysema (father)	6.6	7.8	13.0	2.9	3.6	2.2	-3.0	2.1	-2.7	2.7
High blood pressure (mother)	0.1	0.2	0.6	-0.1	-0.8	0.5	0.4	0.4	0.0	-0.1
Body mass index (BMI)	0.0	0.1	0.3	0.5	-0.4	0.1	0.2	0.6	0.0	0.2
Impedance of leg (left)	0.0	0.1	0.5	-0.4	-0.3	-0.7	0.2	-0.1	-0.3	-0.0
Leg predicted mass (left)	0.5	2.7	6.7	1.9	0.4	1.1	-1.5	2.6	-1.5	1.8
Trunk fat mass	0.1	0.3	1.0	0.8	-0.4	0.2	-0.0	1.0	-0.2	0.5
Waist circumference	0.1	0.5	2.1	-0.1	-1.5	-0.5	1.0	-0.0	0.6	-0.4
Number of incorrect matches in round	0.3	0.6	1.6	0.3	-1.2	-0.8	-0.1	0.6	-1.0	0.6
Past tobacco smoking	0.3	0.6	1.5	1.2	0.5	0.6	-0.0	1.0	-0.2	1.2
Alcohol usually taken with meals	0.2	0.4	1.1	-0.3	-0.5	-0.6	0.3	-1.1	0.7	-0.3
Nervous feelings	0.2	0.3	1.1	-0.3	-0.1	-0.5	1.0	-0.2	0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	3.1	0.0	-0.6	-1.8	0.2	-0.1	0.6	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-0.1	-0.4	-1.3	0.3	-1.1	1.1	-1.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.4	0.4	1.2	1.2	-0.6	0.3	-0.4	0.5
Had menopause	0.5	0.6	1.7	-0.4	1.1	0.7	-0.5	-1.3	0.3	-0.5
Had other major operations	1.0	1.3	2.0	-0.3	1.2	1.4	0.8	-1.4	1.4	-1.0
Forced vital capacity (FVC)	1.4	5.3	10.1	2.1	0.7	0.7	-2.6	3.2	-2.5	2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.4	0.5	-0.6	-0.5	-0.1	-0.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.6	-0.9	-1.2	-0.0	0.5	-0.3	1.3	-0.5
Qualifications: None of the above	0.5	1.1	2.5	-1.1	-0.5	-0.8	1.2	-1.0	1.6	-1.0
Financial difficulties in last 2 years	0.3	0.4	1.7	0.4	-0.5	0.1	0.0	1.3	-0.6	0.2
Mouth/teeth dental problems	0.7	1.1	1.7	1.0	0.8	1.0	-1.2	1.3	-0.9	0.9
Heart attack	1.0	1.3	3.0	-1.3	0.3	-1.2	0.2	-1.7	0.8	-1.5
Allergy	0.3	0.6	2.3	0.0	1.5	1.0	-0.9	-0.0	0.0	0.4
Pain all over the body in last month	0.5	0.6	1.1	0.8	-0.3	1.0	-0.5	0.9	-0.9	0.5
Diabetes (self-reported)	1.1	1.6	5.4	-1.1	-0.6	0.5	1.0	-2.3	0.7	-1.7
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	7.1	-2.2	-1.4	0.3	2.1	-2.5	2.1	-2.7
Medication: Ramipril	0.3	0.4	0.7	0.3	0.5	-0.7	0.0	-0.8	0.7	-0.8
Medication: Simvastatin	1.9	2.8	5.6	1.6	1.9	2.4	-2.0	1.0	-1.6	0.8
Fluid intelligence score	0.3	0.6	1.8	-1.0	-0.5	0.6	0.6	-0.2	1.4	-0.8
Illnesses of siblings	0.6	0.9	1.7	-0.0	0.4	1.3	-0.7	1.2	-1.1	1.0
Neuroticism score	0.5	1.0	2.1	-0.7	-1.4	-1.4	1.2	0.1	0.9	-0.5
Weight	0.2	1.0	3.2	1.3	-0.3	0.3	-0.6	1.8	-0.7	1.1
Impedance of arm (right)	0.0	0.2	1.1	-0.0	0.4	1.1	0.1	-0.1	-0.2	0.1
Arm fat percentage (right)	0.0	0.1	0.6	0.3	-0.2	0.8	0.5	0.2	0.2	0.0
Trunk fat-free mass	0.3	1.7	4.7	1.4	-0.2	0.5	-1.2	2.2	-1.3	1.4
Hip circumference	0.1	0.2	0.5	0.7	-0.5	0.2	-0.0	0.7	-0.4	0.5
Time employed in main current job	1.2	1.4	3.2	-1.2	0.6	0.1	0.9	-1.8	1.6	-1.1
Alcohol intake versus 10 years previously	0.2	0.2	0.7	0.9	0.5	0.3	-0.3	0.0	-0.6	0.3
Father’s age at death	0.3	0.4	1.0	-0.4	-1.0	-0.5	0.8	-0.2	0.4	-0.5
Worrier / anxious feelings	0.4	0.8	2.6	-0.5	-1.6	-1.1	0.9	0.2	1.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.1	0.5	0.3	-1.1	-0.2	-0.3	-0.3	-0.2
Falls in the last year	1.1	1.5	3.9	2.0	0.5	0.7	-0.7	0.7	-1.5	1.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.0	0.1	-0.6	-0.7	1.1	-0.6	0.8
Number of live births	0.2	0.3	0.6	-0.7	0.1	0.3	0.4	-0.6	0.5	-0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.6	1.1	0.1	0.6	-1.5	2.1	-1.4	2.0
Pulse rate	0.8	1.4	3.5	-1.5	-1.9	-1.6	0.7	-0.5	0.6	-0.6
Happiness	0.5	0.6	1.8	0.6	-1.4	-1.1	0.1	0.6	-0.5	0.3
Noisy workplace	0.6	0.7	2.4	1.6	0.8	-0.7	-0.7	0.6	-0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.8	1.0	1.6	1.5	-1.7	0.5	-1.5	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-0.0	-0.9	0.5	1.0	-0.5	0.1	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.7	0.9	1.0	-0.5	0.6	-0.7	0.6
Asthma	0.1	0.2	0.7	0.7	-0.6	-0.8	0.2	-0.2	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.2	1.7	0.7	0.5	-1.1	1.8	-1.5	1.3
Medication: Cholesterol lowering	1.0	1.6	3.4	-1.3	-0.7	-0.8	1.1	-1.9	1.1	-1.6
Depression (self-reported)	0.2	0.3	0.9	-1.0	0.1	0.0	0.6	-0.2	0.4	-0.7
Medication: Lansoprazole	1.1	1.3	2.6	1.2	1.6	1.1	-1.6	-0.3	-0.8	0.5
Prospective memory result	1.0	1.3	2.2	1.4	-0.3	-0.9	-0.7	1.5	-1.3	1.3
Lung cancer (father)	0.1	0.1	0.5	-0.1	0.3	0.4	-0.3	-0.0	-0.7	0.2
Illnesses of mother	0.2	0.2	0.9	-0.6	-0.2	-0.2	0.1	0.4	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	5.4	1.2	0.6	1.0	-1.7	2.3	-1.3	1.7
Pulse wave Arterial Stiffness index	0.4	0.4	2.3	0.5	0.2	-1.5	-0.2	-0.1	-0.5	-0.1
Impedance of arm (left)	0.1	0.3	1.0	0.4	0.6	1.0	-0.1	0.2	-0.4	0.5
Arm fat mass (right)	0.1	0.4	0.9	0.9	-0.2	0.8	-0.0	0.9	-0.2	0.5
Trunk predicted mass	0.3	1.7	4.8	1.4	-0.2	0.6	-1.2	2.2	-1.3	1.4
Standing height	0.3	3.5	9.0	2.1	0.2	0.6	-1.7	3.0	-1.8	2.1
Length of working week for main job	7.8	8.6	13.6	3.7	2.9	2.5	-3.0	1.8	-3.1	3.2
Exposure to tobacco smoke at home	0.3	0.4	0.9	-0.5	0.6	0.6	-0.2	-0.8	-0.4	-1.0
Breastfed as a baby	1.1	1.3	3.0	1.3	1.7	0.7	-1.4	-0.3	-0.9	1.0
Tense / ‘highly strung’	1.0	1.6	2.7	-1.1	-1.6	-1.1	1.1	-1.3	1.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-0.6	0.7	1.1	0.8	0.8	0.2	-0.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	-1.0	0.0	0.4	0.0	-1.3	-0.3	-0.5
Birth weight of first child	2.2	3.9	6.5	-2.2	-1.9	-1.5	2.5	-1.6	1.5	-2.3
Peak expiratory flow (PEF)	0.2	0.5	1.0	-0.4	-1.0	0.2	1.0	1.0	-0.3	0.4
Pulse wave reflection index	0.1	0.2	0.6	0.3	0.3	-0.7	-0.1	-0.5	-0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.4	0.6	-1.2	-1.1	0.2	0.8	-0.6	0.6
Loud music exposure frequency	1.1	1.2	2.0	1.3	0.8	0.4	-1.1	1.4	-1.2	1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.2	0.5	0.3	-0.4	-0.2	-0.6	0.8
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	4.6	-1.8	-2.0	-1.8	2.1	-1.2	1.2	-1.3
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.3	0.4	0.4	-0.2	-0.2	-0.7	-0.2
Medication: Paracetamol	1.0	1.7	3.1	-1.0	-0.7	-1.2	1.2	-1.5	1.5	-1.8
Headache pain in last month	0.2	0.3	1.3	-0.1	-0.1	-1.1	0.5	0.2	-0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.9	1.4	0.5	0.7	-1.2	1.6	-1.4	2.0
Glaucoma (self-reported)	2.2	2.5	6.8	2.6	0.5	0.3	-1.7	1.4	-1.3	2.0
Gout (self-reported)	1.2	1.6	4.1	0.8	1.8	2.0	-1.0	1.4	-0.1	0.9
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	5.7	2.1	1.8	0.5	-2.4	1.9	-2.1	2.3
Medication: Amlodipine	0.3	0.4	1.1	-0.1	1.0	0.3	-1.0	-0.7	-0.4	-0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.3	1.3	-0.0	0.6	-0.7	1.8	-1.5	1.2
Birth weight	0.2	0.5	1.8	-0.3	-1.4	0.0	1.1	-0.0	0.6	-0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	0.9	0.5	0.3	-0.6	0.6	-1.2	0.9
High blood pressure (siblings)	0.2	0.3	1.1	0.5	1.1	-0.2	-0.9	-0.3	0.2	0.1
Forced vital capacity (FVC), Best measure	1.3	4.8	10.6	2.0	1.3	0.9	-2.5	3.3	-2.1	2.4
Body fat percentage	0.0	0.1	0.2	0.4	-0.3	0.3	0.5	0.1	0.1	-0.0
Leg fat percentage (right)	0.0	0.1	0.2	0.3	-0.4	-0.1	0.4	0.0	0.2	-0.2
Arm fat-free mass (right)	0.4	2.3	5.4	1.7	-0.1	0.1	-1.4	2.3	-1.5	1.7
Exposure to tobacco smoke outside home	1.0	1.4	4.6	-1.3	-0.2	1.3	0.4	-2.2	0.2	-1.1
Comparative body size at age 10	0.8	2.2	4.6	2.1	-0.1	-0.0	-0.8	2.0	-1.5	2.0
Number of full brothers	0.5	0.6	1.6	-0.4	1.3	0.7	-0.7	-0.8	-0.1	-0.8
Worry too long after embarrassment	0.1	0.2	0.6	0.0	-0.8	-0.3	-0.1	0.4	0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.6	-0.2	-0.6	0.8	-0.0	-0.3	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.9	-0.6	-0.2	-0.3	0.2	-1.1	0.3
Number of children fathered	1.7	1.9	4.1	-1.7	-0.0	0.6	1.2	-2.0	1.3	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.7	-0.7	-1.9	-1.9	1.0	-0.2	1.4	-0.4
Age at first live birth	0.4	0.6	1.6	0.6	0.5	1.2	-0.3	0.9	-0.6	1.0
Pulse wave peak to peak time	0.4	0.5	2.9	-0.2	0.1	1.7	-0.2	0.4	0.3	0.3
Health satisfaction	0.3	0.4	0.9	0.6	-0.9	0.1	0.2	0.7	-0.9	0.2
Shortness of breath walking on level ground	0.9	1.1	2.4	1.0	-1.3	-0.4	-0.5	1.2	-0.9	1.6
Qualifications: College or University degree	0.1	0.2	0.6	0.2	0.6	0.7	0.1	-0.4	-0.1	-0.3
Eye problems/disorders: None of the above	0.6	0.7	3.3	-1.8	-0.4	-0.7	0.7	-0.0	0.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.0	1.6	0.6	0.4	-1.6	1.1	-1.7	1.7
Emphysema/chronic bronchitis	0.8	0.9	1.9	1.4	0.3	0.2	-1.3	0.9	-1.0	0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	2.7	-0.2	1.1	1.7	-0.5	0.4	-0.7	1.0
Neck or shoulder pain in last month	0.4	0.6	1.6	0.4	-1.1	-1.2	0.9	0.3	0.1	-0.5
Medication: Blood pressure	2.4	4.3	7.7	-2.3	-1.3	-1.1	2.0	-2.4	2.2	-2.8
Angina (self-reported)	1.1	1.4	2.6	-1.3	-0.9	-1.0	1.1	-1.6	0.9	-1.4
Migraine (self-reported)	0.1	0.1	0.2	-0.0	-0.4	0.1	0.2	0.3	-0.1	0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.2	0.1	0.4	0.2	0.5	-0.3	0.2
Medication: Allopurinol	0.6	0.8	2.3	0.5	1.3	1.5	-0.3	1.1	-0.2	0.5
Medication: Omeprazole	0.5	0.6	1.5	1.1	-0.7	-0.8	-0.5	1.2	0.1	0.4
Medication: Seretide 50 evohaler	2.5	2.9	8.8	3.0	1.8	-0.2	-1.8	1.2	-1.1	1.5
Mean time to correctly identify matches	0.8	1.5	4.4	0.8	1.3	1.1	-1.2	0.2	-2.1	1.1
Heart disease (mother)	0.5	0.6	1.2	-0.6	-0.5	-1.1	0.8	-0.6	0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.1	1.1	1.1	-0.8	-0.1	-0.4	0.6
Whole body fat mass	0.1	0.3	0.7	0.8	-0.5	0.3	0.0	0.8	-0.3	0.5
Leg fat mass (right)	0.1	0.2	0.9	0.7	-0.3	0.1	-0.1	0.9	-0.3	0.4
Arm predicted mass (right)	0.5	2.4	6.1	1.7	-0.1	0.0	-1.5	2.5	-1.5	1.7
Pulse rate, automated reading	0.7	2.3	4.6	1.9	1.0	0.5	-2.2	1.6	-1.0	1.7
Alcohol intake frequency.	0.5	1.2	1.9	-1.1	0.0	1.3	1.0	-0.8	1.4	-1.4
Comparative height size at age 10	0.2	1.3	3.8	1.1	-1.0	-1.1	-0.6	2.0	-0.4	1.2
Number of full sisters	0.9	1.2	3.5	0.8	0.9	1.9	-1.1	0.9	-0.4	0.9
Suffer from ‘nerves’	0.2	0.3	1.1	0.3	0.3	-1.0	-0.2	0.5	-0.8	0.4
Overall health rating	0.3	0.6	2.5	1.6	0.4	-0.0	-0.9	0.1	-0.7	0.4
Chest pain or discomfort	0.7	1.0	2.6	0.4	-1.6	-1.6	0.9	-0.7	0.5	-0.4
Had major operations	0.3	0.3	0.7	0.7	0.8	0.9	-0.2	-0.5	0.4	-0.4
Age at last live birth	0.4	0.6	2.1	-0.8	0.7	1.5	0.6	-0.2	-0.0	-0.5
Family relationship satisfaction	0.7	0.9	4.3	-0.2	-2.1	-0.8	0.6	-0.2	0.8	-0.0
Leg pain on walking	0.1	0.2	0.7	0.9	-0.0	0.1	-0.2	-0.2	-0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.7	0.0	0.9	1.6	-1.4	0.3	-0.7	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	3.3	-0.1	0.4	1.8	0.0	-0.6	0.0	-0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	-1.0	-0.2	-0.8	0.9	-1.1	1.2	-0.8
Medication: Aspirin	0.9	1.2	2.9	-0.4	-1.7	-1.6	0.8	-0.5	0.8	-1.0
Supplements: Vitamin C	0.3	0.4	1.9	0.5	0.2	-1.4	-0.2	0.5	-0.1	0.4
Knee pain experienced in last month	1.2	1.8	3.6	-1.0	-1.0	-1.2	1.7	-1.1	1.9	-1.3
Hypertension (Self-reported)	0.1	0.2	0.5	0.1	0.5	-0.2	-0.5	-0.3	0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	4.1	0.4	-1.5	-2.0	0.1	0.4	0.6	0.6
Illnesses of father: Heart disease	0.4	0.6	1.5	-0.3	-0.5	-0.3	0.8	-1.0	1.2	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.1	-0.6	0.1	0.3	-0.5	0.2	-0.8
Smoking status: Previous	0.7	1.0	2.3	-1.2	-0.9	-1.0	0.4	-0.8	0.9	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	1.3	0.5	0.0	-0.8	1.7	-1.0	0.8
Whole body fat-free mass	0.4	2.1	5.8	1.6	-0.1	0.7	-1.4	2.4	-1.4	1.6
Leg fat-free mass (right)	0.5	2.4	5.9	1.7	0.3	1.0	-1.5	2.4	-1.5	1.7
Arm fat percentage (left)	0.0	0.2	0.5	0.5	-0.1	0.7	0.5	0.3	0.1	0.1
Average weekly red wine intake	0.2	0.3	1.6	0.4	0.1	0.2	-0.6	-1.3	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.1	0.3	1.5	1.3	-0.7	-0.7	-0.4	-0.4
Mood swings	0.2	0.3	0.9	0.1	-0.9	-0.9	0.8	0.4	-0.3	-0.1
Loneliness, isolation	0.8	1.2	3.4	-1.0	-0.4	-1.8	0.8	-0.4	1.1	-1.1
Long-standing illness, disability or infirmity	0.3	0.5	1.1	0.3	-0.4	-1.1	0.5	-0.9	-0.1	-1.0
Ever had bowel cancer screening	0.1	0.1	0.4	-0.4	0.2	-0.2	-0.6	0.2	0.3	-0.3
Diabetes diagnosed by doctor	0.4	0.6	3.2	-0.2	-0.3	0.2	0.4	-1.8	0.1	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	3.7	1.4	1.9	1.9	-1.2	1.5	-1.5	1.3
Friendships satisfaction	0.3	0.3	1.3	0.1	-1.2	-0.6	0.8	-0.2	0.4	-0.1
Qualifications: nursing, teaching	1.8	2.7	5.0	1.6	1.4	1.5	-1.3	1.4	-2.2	1.9
Commuting to job workplace: Walk	1.3	1.4	4.7	0.1	-1.7	-2.2	1.1	-0.6	0.8	-0.4
Eye problems/disorders: Cataract	0.2	0.3	1.1	0.5	1.0	0.4	-0.3	-0.4	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	4.8	7.7	13.5	-3.2	-1.1	-0.3	2.8	-3.7	2.7	-3.7
Medication for cholesterol	0.2	0.4	0.6	-0.4	-0.8	-0.7	0.7	0.4	-0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.2	0.6	-0.1	-1.0	-0.1	-0.1	-0.0
Back pain experienced in last month	1.1	1.6	6.2	1.3	2.5	0.4	-1.5	0.1	-0.8	0.4
Mineral and other dietary supplements	0.4	0.6	1.0	1.0	0.2	0.3	-0.6	1.0	-0.8	1.0
Breast cancer (self-reported)	1.9	2.2	4.1	-0.8	-1.1	0.4	1.9	-2.0	1.8	-1.5
Asthma (self-reported)	0.1	0.3	1.0	1.0	-0.6	-0.6	0.0	0.1	-0.3	0.3
Osteoporosis (self-reported)	0.3	0.4	1.5	0.5	0.7	0.3	-0.2	1.2	-0.6	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.6	-0.4	-0.2	-0.8	-0.4	-0.5	0.3	0.0
Medication: Aspirin	1.3	1.6	3.3	-0.9	-1.8	-1.4	1.2	-0.7	1.2	-1.4
Medication: Gliclazide	0.4	0.5	1.4	-0.2	0.9	0.8	-0.4	-1.2	-0.5	-0.4
Illnesses of father: None of the above (group 1)	1.2	1.5	3.7	0.8	1.2	0.7	-1.2	1.9	-0.9	1.3
Smoking status: Current	0.2	0.3	0.7	0.2	0.7	0.3	-0.8	-0.2	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	-0.3	0.4	0.9	-0.4	0.2	-0.2	0.1
Whole body water mass	0.4	2.3	5.8	1.7	-0.1	0.6	-1.4	2.4	-1.4	1.7
Leg predicted mass (right)	0.5	2.5	6.0	1.7	0.3	1.0	-1.5	2.4	-1.5	1.7
Arm fat mass (left)	0.1	0.4	1.0	0.9	-0.3	0.6	0.0	1.0	-0.2	0.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.7	-0.7	-0.5	-1.4	0.4	-1.6	0.8	-1.4
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.4	-0.5	-0.8	-0.5	0.9	-0.3	0.6
Miserableness	0.2	0.3	0.8	-0.1	-0.1	-0.9	0.3	-0.6	0.9	-0.5
Guilty feelings	0.1	0.2	0.8	0.2	0.9	0.5	-0.3	0.4	0.2	-0.2
Wears glasses or contact lenses	0.4	0.5	1.8	-0.2	-0.5	-0.0	0.6	-1.3	0.8	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.7	-0.4	0.1	-0.9	-0.0	-0.6	0.3	-0.3
Hearing aid user	0.3	0.3	1.1	-0.3	-0.3	-0.1	0.5	-0.7	1.1	-0.2
Mother’s age at death	1.2	1.5	3.0	1.7	1.3	0.7	-1.1	1.0	-1.5	1.0
Financial situation satisfaction	0.3	0.3	0.9	-0.8	-0.5	0.3	0.4	-0.3	-0.0	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.3	0.6	-1.1	-1.1	-0.2	0.5	-0.1	0.8
Commuting to job workplace: Public transport	0.5	0.6	1.3	-1.1	0.2	-0.4	1.1	-0.3	1.1	-0.5
Eye problems/disorders: Glaucoma	1.1	1.4	3.9	2.0	0.5	0.5	-1.1	0.9	-1.1	1.4
Medication: Blood pressure	0.5	1.0	2.6	1.5	1.0	0.3	-1.6	0.3	-0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	1.1	0.4	-0.3	-0.5	-0.1	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.3	-0.4	0.6	1.1	-0.4	-0.3	-0.1	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.1	-0.5	0.0	0.7	0.1	-1.0	0.1	-1.1
Medication: Bendroflumethiazide	0.3	0.5	1.7	-0.2	-0.1	-0.5	-0.3	-1.3	0.8	-0.8
Medication: Paracetamol	0.7	1.0	1.9	-1.0	-0.8	-0.9	1.0	-0.8	1.1	-1.4
Medication: Lisinopril	0.8	1.1	1.8	1.1	0.8	0.6	-1.3	0.7	-1.2	1.3
Medication: Atorvastatin	3.2	3.9	4.9	-2.2	-2.1	-1.9	2.0	-2.2	1.6	-1.9
Illnesses of father: High blood pressure	0.9	1.1	2.0	-0.9	-1.0	0.5	1.2	-1.4	0.7	-1.3
Alcohol drinker status: Never	2.2	2.6	4.5	-1.6	-1.8	-0.9	1.9	-1.1	2.1	-1.5
Ever smoked	0.1	0.2	0.9	-0.9	-0.3	-0.3	-0.2	-0.4	-0.2	-0.6
Basal metabolic rate	0.4	2.3	6.2	1.7	-0.0	0.7	-1.3	2.5	-1.4	1.7
Leg fat percentage (left)	0.0	0.1	0.1	0.2	-0.4	-0.2	0.3	-0.1	0.2	-0.3
Arm fat-free mass (left)	0.3	1.4	4.0	1.3	-0.4	0.0	-1.0	2.0	-1.1	1.3
Number of operations (self-reported)	1.1	1.7	4.1	1.3	2.0	1.9	-0.8	-1.1	0.3	-0.4
Average weekly beer plus cider intake	0.0	0.1	0.2	-0.1	-0.5	0.1	0.4	0.1	0.0	0.1
Irritability	0.3	0.5	1.5	-0.6	-0.8	-1.2	0.8	-0.1	0.3	-0.4
Risk taking	0.4	0.6	1.3	-0.6	-1.1	-0.7	0.6	0.2	0.9	-1.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.1	-0.0	0.7	-0.6	0.2	-0.6	1.1	-0.7
Fractured/broken bones in last 5 years	2.4	3.0	6.5	2.5	0.0	0.2	-1.4	2.3	-1.6	2.2
Age started oral contraceptive pill	0.9	1.1	2.4	1.1	1.3	-0.2	-1.5	0.3	-1.2	1.0
Diastolic blood pressure, automated reading	0.3	0.8	1.6	1.1	1.2	1.3	-1.1	0.2	-0.4	0.4
Ever depressed for a whole week	0.2	0.2	0.6	-0.3	-0.8	0.7	-0.2	0.1	0.4	0.4
Unable to work because of sickness or disability	0.2	0.3	0.9	0.4	0.1	-0.7	0.9	0.2	0.5	-0.5
Commuting to job workplace: Cycle	0.5	0.6	2.1	-0.4	-1.4	-1.4	-0.1	-0.0	-0.0	0.5
Myopia	0.9	1.3	1.9	-1.2	-0.5	-1.2	1.3	-1.4	0.6	-1.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.1	-0.2	-0.8	0.4	1.0	0.4	-0.1	0.6
Cholesterol lowering medication	1.2	1.8	3.9	1.4	1.4	1.9	-2.0	0.6	-0.9	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	1.0	-0.2	-0.5	-1.1	1.0	-0.2	0.4
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.5	0.5	0.2	0.4	0.2	0.3
Supplements: Calcium	0.4	0.5	2.7	0.4	0.1	-1.6	-0.5	-0.4	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	-0.4	1.3	1.3	-0.4	-0.8	-0.0	-0.8
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.4	-1.3	0.2	-1.2	0.3	-1.8	0.8	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	0.3	0.7	0.5	-0.4	-0.3	-0.5	-0.3
Heart disease (siblings)	4.3	5.3	7.9	-2.0	-2.0	-1.6	2.5	-2.8	2.4	-2.4
Alcohol drinker status: Previous	0.9	1.1	2.4	-1.6	0.5	0.2	0.7	-1.0	1.3	-1.3
Pack years of smoking	0.5	0.7	1.5	-1.0	-0.1	0.1	1.1	-0.3	1.0	-1.2
Impedance of whole body	0.0	0.2	0.3	0.4	0.5	0.5	-0.3	0.4	-0.6	0.5
Leg fat mass (left)	0.1	0.2	0.8	0.7	-0.2	0.1	-0.2	0.9	-0.4	0.5
Arm predicted mass (left)	0.4	1.8	4.5	1.5	-0.1	0.4	-1.4	2.1	-1.3	1.5