TWAS hub - SLC16A6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.4850	0.111	9.3e-04	0.026	NA	0.061	NA	0.073	5.9e-02	NA	8.0e-03	NA	4.0e-03
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2260	0.067	3.9e-04	0.100	NA	0.088	NA	0.065	4.2e-06	NA	1.5e-05	NA	1.8e-04
3	YFS	Blood	0.0628	0.015	2.4e-09	0.040	0.036	0.044	0.043	0.048	5.8e-13	6e-12	3.0e-14	8.2e-14	2.7e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.4	6.3	12.6	0.4	3.5	2.5
Coronary Artery Disease (CAD)	4.9	5.9	6.1	2.5	-2.4	-2.5
Supplements: Fish oil (including cod liver oil)	3.6	4.6	8.0	-2.8	0.9	2.2
Medication: Omeprazole	2.9	3.5	4.5	1.9	2.1	-1.5
Pack years adult smoking proportion	2.8	4.2	10.3	-1.4	0.5	-3.2
Heart disease (mother)	2.8	3.4	8.5	-1.3	-0.4	-2.9
Eye problems/disorders: Glaucoma	2.8	3.3	5.8	2.4	2.0	-0.3
Pack years of smoking	2.8	4.0	9.6	-1.4	0.8	-3.1
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	8.7	-0.3	-0.5	-3.0
Serious illness, injury or assault to yourself	2.6	3.2	5.3	2.3	0.2	2.1
Standing height	2.6	26.1	55.2	3.5	3.3	7.4
Supplements: Vitamin C	2.6	3.1	6.7	-1.2	1.1	2.6
Heart disease (siblings)	2.6	3.2	4.7	2.2	2.1	-0.7
Height	2.5	48.1	106.1	3.9	4.8	10.3
Ever had prostate specific antigen (PSA) test	2.5	2.9	7.7	-0.4	2.8	0.9
HbA1C	2.4	2.7	5.2	2.3	-0.2	-1.7
Current tobacco smoking	2.4	3.9	9.5	0.3	-1.5	-3.1
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	9.5	-2.5	-0.8	-3.1
Mouth/teeth dental problems	2.4	3.7	8.2	-2.9	1.5	0.8
Medication: Lansoprazole	2.4	2.7	7.1	-0.2	2.7	1.0
Mineral and other dietary supplements	2.4	3.3	6.4	0.8	-1.7	-2.5
Medication: Gliclazide	2.4	2.7	6.5	-2.5	1.1	0.7
Heel T-Score	2.1	16.5	25.0	-4.5	-2.1	-5.0
Glaucoma (self-reported)	2.1	2.5	5.5	2.3	1.4	-0.2
Angina (self-reported)	2.1	2.8	4.2	1.5	2.0	-1.4
Angina	2.0	2.7	4.0	1.4	2.0	-1.4
Severe depression (siblings)	2.0	2.2	6.2	-0.2	-0.6	2.5
Medication: Cholesterol lowering	2.0	3.1	6.0	1.5	1.1	-2.4
Exposure to tobacco smoke at home	2.0	2.2	4.0	-0.6	1.5	2.0
Shortness of breath walking on level ground	2.0	2.3	3.8	-0.3	1.9	1.8
Average weekly champagne plus white wine intake	2.0	2.7	3.1	1.5	-1.7	-1.8
Hearing aid user	2.0	2.3	5.9	2.4	0.9	0.4
Medication: Bendroflumethiazide	2.0	3.0	8.6	-2.9	-0.1	-0.5
Myopia	2.0	2.9	7.7	0.8	0.6	2.8
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.4	1.4	1.9	-1.4
Bipolar Disorder (2011)	1.9	1.9	3.3	1.0	1.2	1.8
Eye problems/disorders: None of the above	1.9	2.3	4.3	-0.7	-1.4	2.1
Smoking status: Current	1.9	3.1	7.3	0.1	-1.4	-2.7
Mother’s age at death	1.9	2.3	4.7	0.6	1.4	2.2
Verbal and Numeric Reasoning (VNR)	1.8	4.2	6.0	-2.3	-1.2	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	6.8	-2.4	-0.1	-2.6
Intelligence (Savage-Jansen 2018)	1.7	5.1	11.1	-3.3	-0.8	-1.9
Medication for hormone replacement therapy	1.7	1.9	2.7	0.4	1.6	1.7
Heart attack	1.7	2.1	5.7	2.4	-0.2	-0.8
Birth weight	1.7	3.6	6.0	0.8	2.1	2.4
Medication for cholesterol	1.7	2.6	3.8	1.9	-1.6	-1.3
Ever smoked	1.7	3.0	7.2	-0.6	-1.2	-2.7
Schizophrenia vs Biploar Disorder	1.6	2.1	5.9	-0.6	-2.4	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	5.2	0.2	-1.1	-2.3
Supplements: Glucosamine	1.6	2.2	5.0	1.0	0.6	2.2
Comparative height size at age 10	1.6	8.6	14.1	1.9	2.8	3.8
Commuting to job workplace: Cycle	1.6	1.9	5.0	0.3	-2.2	0.8
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.5	2.4	0.2	-0.9
Triglycerides	1.5	2.4	5.7	-1.0	0.7	-2.4
Hair/balding pattern: Pattern 3	1.5	2.3	6.6	0.5	0.1	2.6
Medication: Allopurinol	1.5	2.0	4.0	1.3	0.6	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.8	1.7	1.4	0.9
Medication: Paracetamol	1.5	2.3	6.2	0.7	-0.6	-2.5
Reaction Time	1.4	2.7	4.6	1.4	-2.1	1.3
Medication: Atenolol	1.4	1.8	3.2	-1.8	1.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	5.6	-0.8	0.7	-2.4
Number of live births	1.4	2.0	3.1	-0.4	-1.8	-1.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.1	-0.9	0.1	2.5
Mean time to correctly identify matches	1.4	2.6	4.8	2.2	-1.1	1.4
Chest pain or discomfort	1.4	2.0	3.7	1.9	-0.1	-1.5
Loneliness, isolation	1.4	2.0	4.8	-2.2	1.0	0.4
Bipolar Disorder (2018)	1.3	2.0	4.6	1.2	2.1	0.2
Crohns Disease (2017)	1.3	2.9	5.1	-1.9	2.3	-0.1
Crohns Disease (2012)	1.3	2.0	5.7	0.5	2.4	0.4
Fasting Glucose	1.3	1.6	3.2	-1.8	-0.3	-1.2
Hearing difficulty/problems: Yes	1.3	1.9	2.6	1.0	1.5	1.6
Hearing difficulty/problems with background noise	1.3	2.0	4.5	1.2	2.1	0.6
Had menopause	1.3	1.6	2.5	-1.6	-1.1	-1.0
Impedance of arm (right)	1.3	5.9	14.8	-1.5	0.8	3.9
Time employed in main current job	1.3	1.5	2.6	-1.4	1.6	0.4
Hair/balding pattern: Pattern 4	1.3	3.0	5.7	-2.4	0.1	-1.9
Health satisfaction	1.3	1.7	4.0	1.1	2.0	-0.1
Neck or shoulder pain in last month	1.3	1.9	2.6	1.2	1.2	1.6
Medication: Blood pressure	1.3	2.4	6.7	-2.6	0.3	0.7
Mean Putamen Volume	1.2	1.4	2.6	-0.9	1.6	-0.9
Allergy or Eczema	1.2	3.2	5.4	-0.9	1.9	2.3
Alcohol usually taken with meals	1.2	2.0	4.8	2.2	0.7	0.8
Fluid intelligence score	1.2	2.5	3.5	-1.1	-1.9	-1.7
Noisy workplace	1.2	1.5	1.9	-1.2	1.4	-1.0
Asthma	1.2	2.4	3.6	1.9	-1.8	0.6
Illnesses of mother	1.2	1.5	4.3	-0.3	-0.1	2.1
Tense / ‘highly strung’	1.2	1.9	3.8	1.4	-1.9	-0.1
Loud music exposure frequency	1.2	1.3	3.2	-0.7	0.5	-1.8
Illnesses of siblings: Diabetes	1.2	1.5	2.1	-0.7	-1.3	-1.5
Back pain experienced in last month	1.2	1.8	2.8	1.7	1.5	-0.6
Asthma (self-reported)	1.2	2.4	4.2	2.1	-1.6	0.6
Smoking Status	1.1	2.6	6.6	-0.7	-0.8	-2.6
Chronotype (morning person)	1.1	2.6	4.2	0.6	-2.1	-1.8
Age when periods started (menarche)	1.1	2.7	6.8	0.7	0.8	2.6
Stomach or abdominal pain in last month	1.1	1.4	3.9	-0.3	0.4	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	2.7	-0.8	-1.6	-1.4
Comparative body size at age 10	1.1	3.1	5.0	-0.9	-2.2	-1.8
Medication for pain relief, constipation, heartburn	1.1	1.9	4.0	-2.0	-0.6	1.2
Medication: Seretide 50 evohaler	1.1	1.3	2.1	1.5	-0.8	1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.8	1.3	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.4	0.9	-0.8	2.3
Illnesses of father: High blood pressure	1.1	1.3	2.6	-0.6	-1.0	-1.6
Diastolic blood pressure, automated reading	1.1	3.5	7.0	1.8	0.7	-2.6
Bipolar Disorder or Schizophrenia	1.0	2.5	3.4	1.1	1.8	1.8
Lupus	1.0	1.6	2.5	-1.4	-1.6	0.6
Hand grip strength (left)	1.0	2.5	5.1	2.3	-1.4	-0.7
Supplements: Zinc	1.0	1.1	3.3	-0.1	-1.8	0.1
Diabetes (mother)	1.0	1.3	2.4	-0.9	-0.8	-1.6
Taking other prescription medications	1.0	1.5	2.3	1.4	1.5	-0.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.5	1.2	1.1	1.0
Mouth/teeth dental problems: Dentures	1.0	1.7	3.2	1.8	0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.4	0.3	-2.1	-0.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	0.9	-0.9	-1.4
Commuting to job workplace: Walk	1.0	1.0	2.8	-0.5	0.3	1.7
Wears glasses or contact lenses	1.0	1.2	2.7	1.6	0.1	0.9
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.5	0.2	-1.1	-1.6
Irritability	1.0	1.8	2.9	0.6	-1.7	-1.4
Pain experienced in last month	1.0	1.7	3.0	-1.3	-0.7	-1.7
Alzheimer’s Disease (in mother)	0.9	1.1	2.4	1.6	-0.7	0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	2.1	1.5	-1.3	0.4
Irritable Bowel Disease (IBD)	0.9	2.1	3.4	-1.8	1.7	0.3
Major Depression (MDD)	0.9	1.1	3.4	0.1	-0.1	-1.8
Prostate Cancer	0.9	1.3	2.0	1.4	1.4	-0.1
Primary Biliary Cirrhosis	0.9	1.2	3.0	-0.1	1.7	0.8
Financial difficulties in last 2 years	0.9	1.2	1.8	-0.0	-1.3	1.3
Impedance of arm (left)	0.9	4.3	11.7	-1.0	0.4	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.9	1.2	-1.4	-0.1
Friendships satisfaction	0.9	1.1	1.7	-0.9	-1.3	-0.9
Eye problems/disorders: Cataract	0.9	1.1	1.6	0.5	1.3	-1.2
Financial situation satisfaction	0.9	1.1	3.1	-1.8	-0.0	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.8	1.3	0.8	0.8
High cholesterol (Self-reported)	0.9	1.5	4.6	-0.0	0.0	-2.1
Medication: Lisinopril	0.9	1.1	1.6	-1.3	-1.0	-0.9
Number of operations (self-reported)	0.9	1.4	3.4	0.1	1.9	0.8
Schizophrenia (2018)	0.8	1.7	4.4	0.5	0.6	2.1
Ovarian Cancer	0.8	1.0	1.6	-1.3	-0.1	-1.2
Past tobacco smoking	0.8	1.4	2.6	0.2	1.3	1.6
Hair/balding pattern: Pattern 2	0.8	1.0	2.2	1.5	-0.8	0.6
Medication: Ramipril	0.8	1.1	2.6	0.6	1.6	-0.5
Lung cancer (father)	0.8	1.0	1.5	-1.2	-0.8	-0.8
Blood clot in the leg (DVT)	0.8	1.0	1.2	1.0	0.9	1.1
Medication: Amlodipine	0.8	1.2	2.1	-1.5	0.3	-1.1
Worry too long after embarrassment	0.8	1.3	2.5	-1.6	0.1	1.2
Age at first live birth	0.8	1.4	2.6	1.1	-0.6	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.4	1.2	0.8	-0.9
Commuting to job workplace: Public transport	0.8	1.0	2.5	-0.3	-1.6	0.6
Medication: Atorvastatin	0.8	0.9	2.3	0.0	-1.5	-0.7
Basal cell carcinoma (self-reported)	0.8	0.9	1.6	0.6	-0.9	1.2
Depression (Nagel 2018)	0.7	1.1	2.7	-0.0	-0.8	-1.6
Number of treatments/medications taken	0.7	1.3	3.6	0.6	0.1	-1.9
Townsend deprivation index at recruitment	0.7	1.0	2.0	-0.9	1.4	0.4
Maternal smoking around birth	0.7	0.9	1.7	-0.2	-1.0	-1.3
Relative age voice broke	0.7	1.1	2.2	1.1	0.1	1.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	-1.4	-0.0	0.7
Medication: Simvastatin	0.7	1.1	1.8	-0.1	1.2	-1.3
Trunk fat-free mass	0.7	4.1	5.7	2.2	1.4	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	1.5	0.7	0.2
Prospective memory result	0.7	0.9	1.6	-0.8	1.3	0.6
Trunk predicted mass	0.7	4.0	5.6	2.1	1.3	2.4
Length of working week for main job	0.7	0.8	1.8	-0.5	-1.4	-0.6
Breastfed as a baby	0.7	0.9	2.2	-0.7	-0.1	1.5
Medication: Paracetamol	0.7	1.2	2.5	0.8	-0.6	-1.6
Exposure to tobacco smoke outside home	0.7	0.9	1.3	1.1	1.1	0.4
Had major operations	0.7	0.8	1.3	0.4	1.1	1.0
Leg fat-free mass (right)	0.7	3.5	4.1	1.5	2.0	2.0
Guilty feelings	0.7	1.0	2.7	0.5	-1.6	0.2
Age started oral contraceptive pill	0.7	0.9	1.1	0.8	1.0	1.0
Age at First Birth	0.6	0.9	1.6	-0.6	1.3	0.8
Rheumatoid Arthritis	0.6	0.9	1.6	0.3	1.3	1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	-0.8	-0.6	-1.1
Average weekly spirits intake	0.6	0.8	2.2	-0.1	-0.1	-1.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	-1.1	0.3	0.8
Medication: Metformin	0.6	0.8	2.4	0.2	0.2	-1.6
Leg fat-free mass (left)	0.6	3.0	3.6	1.4	1.8	1.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	-0.4	-1.2	0.5
Multivitamins +/- minerals	0.6	0.8	1.5	-0.6	-1.2	-0.5
High blood pressure (mother)	0.6	0.8	2.4	1.5	-0.4	0.0
Leg predicted mass (left)	0.6	3.0	3.5	1.4	1.9	1.9
Pain all over the body in last month	0.6	0.6	1.4	1.2	-0.5	0.3
Weight	0.6	2.8	3.6	1.3	1.7	1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.9	2.2	-0.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.6	1.9	-0.6	1.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	-0.5	0.8	1.1
Peak expiratory flow (PEF)	0.6	1.3	3.8	1.9	-0.3	0.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	0.8	0.6	1.2
Chronic bronchitis/emphysema (mother)	0.6	0.6	0.9	-0.9	0.9	-0.6
Medication: Blood pressure	0.6	1.1	1.8	1.2	-0.3	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	1.3	0.6	0.4
Knee pain experienced in last month	0.6	1.0	2.1	0.7	0.6	1.4
Whole body fat-free mass	0.6	3.3	4.2	1.9	1.4	2.1
Average weekly red wine intake	0.6	0.8	1.1	0.8	1.1	-0.8
Mood swings	0.6	1.1	3.1	1.8	0.3	0.0
Whole body water mass	0.6	3.3	4.4	1.9	1.4	2.1
Leg predicted mass (right)	0.6	3.3	4.0	1.5	1.9	2.0
Ever taken oral contraceptive pill	0.6	0.7	1.3	-0.4	1.2	0.6
Basal metabolic rate	0.6	3.3	4.1	1.8	1.5	2.0
Ulcerative Colitis (UC)	0.5	0.9	2.2	-1.5	0.5	0.5
HDL Cholesterol	0.5	0.9	1.0	-0.8	1.0	1.0
Schizophrenia (2014)	0.5	1.2	1.5	1.1	1.2	0.9
Lung FVC	0.5	2.7	4.5	0.0	-2.1	-1.9
Diabetes (father)	0.5	0.6	1.4	0.1	-0.7	-1.2
Hand grip strength (right)	0.5	1.4	2.2	1.2	-0.7	-1.5
Qualifications: CSEs or equivalent	0.5	0.6	1.7	0.3	-1.3	0.4
High blood pressure	0.5	1.5	2.9	-0.1	-1.7	-1.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.5	-0.9	0.9	1.2
Sitting height	0.5	3.8	5.0	2.1	1.5	2.2
Trunk fat mass	0.5	2.0	3.0	0.1	1.7	1.7
Had other major operations	0.5	0.6	1.7	-0.3	1.3	0.0
Forced vital capacity (FVC)	0.5	1.8	3.1	1.8	0.1	1.5
Qualifications: None of the above	0.5	1.1	3.1	0.3	1.7	0.5
Pulse rate	0.5	0.8	2.3	-0.3	0.2	-1.5
Depression (self-reported)	0.5	0.6	1.6	-0.5	0.0	1.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	0.5	-1.3	0.2
Forced vital capacity (FVC), Best measure	0.5	2.0	3.5	1.5	-0.4	1.9
Number of children fathered	0.5	0.6	1.6	-0.5	-0.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.1	1.1	-0.3	0.6
Pulse wave peak to peak time	0.5	0.5	0.9	1.0	-0.5	-0.7
Medication: Ibuprofen	0.5	0.6	1.2	1.1	0.8	-0.3
Number of full sisters	0.5	0.5	1.6	-1.3	0.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	-0.9	-0.7	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.1	1.1	-0.7	0.5
Alcohol drinker status: Never	0.5	0.5	1.6	-0.2	0.1	-1.3
Arm fat-free mass (left)	0.5	2.5	4.2	2.0	1.2	1.4
Unable to work because of sickness or disability	0.5	0.6	0.9	0.9	0.4	-0.9
Impedance of whole body	0.5	2.6	7.2	-0.6	-0.4	2.7
Neuroticism (2016)	0.4	0.5	0.8	0.4	-0.8	-0.9
Cardiovascular Disease	0.4	1.5	2.4	-0.0	-1.4	-1.6
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.5	0.5	1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	-1.5	-0.2	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.8	-0.1	-0.9
Allergy	0.4	0.9	2.2	0.2	-0.7	-1.5
Diabetes (self-reported)	0.4	0.7	1.3	-1.1	-0.4	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	0.7	0.6	0.8	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	-0.3	1.0	-0.5
Pulse wave reflection index	0.4	0.5	0.8	-0.8	-0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	0.9	0.6	-0.9	-0.9
Gout (self-reported)	0.4	0.5	0.7	0.8	0.8	-0.5
Arm predicted mass (right)	0.4	2.1	4.8	2.2	0.8	1.0
Pulse rate, automated reading	0.4	1.2	3.0	-0.5	-0.5	-1.7
Suffer from ‘nerves’	0.4	0.6	1.2	0.4	-1.1	0.6
Age at last live birth	0.4	0.6	1.2	-0.1	-0.8	1.1
Leg pain on walking	0.4	0.5	0.9	0.3	1.0	-0.8
Diabetes diagnosed by doctor	0.4	0.7	1.8	-1.3	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	0.1	-1.5	0.3
Miserableness	0.4	0.7	1.2	0.9	-1.1	0.4
Average weekly beer plus cider intake	0.4	0.5	0.7	-0.8	-0.5	-0.9
Ever depressed for a whole week	0.4	0.5	0.8	-0.0	0.8	0.9
Cholesterol lowering medication	0.4	0.6	1.3	-1.1	0.7	0.1
Blood Platelet Count	0.3	3.1	5.6	2.4	1.9	0.1
Blood White Count	0.3	2.1	5.7	0.6	-0.7	-2.4
Waist Hip Ratio (WHR)	0.3	1.3	2.4	-0.0	-1.2	1.6
Sensitivity / hurt feelings	0.3	0.6	1.1	-0.6	0.6	1.0
Relative age of first facial hair	0.3	0.7	2.0	0.2	-0.1	1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.6	0.6	0.8
Impedance of leg (right)	0.3	1.5	3.3	-0.7	-1.8	0.9
Trunk fat percentage	0.3	1.2	1.7	-0.6	1.2	1.3
Fed-up feelings	0.3	0.6	0.8	0.7	0.7	-0.9
Impedance of leg (left)	0.3	1.4	3.0	-0.8	-1.7	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.9	0.6	-0.1
Illnesses of siblings	0.3	0.5	1.2	-0.0	-1.1	0.4
Hip circumference	0.3	1.1	2.0	0.4	1.4	1.0
Falls in the last year	0.3	0.4	0.8	-0.6	-0.3	-0.9
Happiness	0.3	0.4	0.6	-0.8	0.6	0.6
Birth weight of first child	0.3	0.6	0.8	0.9	0.8	0.8
Arm fat-free mass (right)	0.3	1.5	3.3	1.8	0.8	0.7
Qualifications: College or University degree	0.3	0.9	1.5	-0.4	-1.2	-1.0
Overall health rating	0.3	0.6	1.4	0.4	1.2	-0.4
Hypertension (Self-reported)	0.3	0.9	1.4	-0.3	-1.2	-1.2
Long-standing illness, disability or infirmity	0.3	0.5	0.7	-0.8	0.5	-0.7
Ever had bowel cancer screening	0.3	0.4	0.7	-0.7	0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.6	0.7	-0.8	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	1.0	-0.2	0.4
Risk taking	0.3	0.4	1.0	-0.0	1.0	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.2	-0.5	0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.4	0.8	0.6
Arm predicted mass (left)	0.3	1.7	2.4	1.6	0.9	1.4
Worry (Nagel 2018)	0.2	0.3	0.8	-0.1	-0.5	-0.9
Breast Cancer	0.2	0.4	0.9	1.0	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.1	0.6	-0.8
LDL Cholesterol	0.2	0.3	0.7	0.1	-0.4	-0.9
Ulcerative Colitis	0.2	0.4	0.8	-0.9	0.4	-0.2
BMI	0.2	1.4	4.1	-0.2	0.3	-2.0
Lung FEV1/FVC ratio	0.2	1.1	2.8	1.7	-0.3	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.5	-0.2	-0.8
Systolic blood pressure, automated reading	0.2	0.5	1.0	0.8	1.0	0.1
Vitamin and mineral supplements	0.2	0.2	0.4	-0.3	0.3	-0.6
Medication: Co-codamol	0.2	0.2	0.7	-0.9	0.1	-0.0
Body mass index (BMI)	0.2	0.7	2.0	-0.2	0.3	-1.4
Number of incorrect matches in round	0.2	0.3	0.3	0.6	-0.4	-0.5
Arm fat percentage (right)	0.2	0.8	1.2	-1.1	1.0	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.7	-0.3	-0.8	-0.5
High blood pressure (siblings)	0.2	0.3	0.9	-0.2	0.1	-0.9
Body fat percentage	0.2	0.7	1.3	-0.8	1.1	0.5
Number of full brothers	0.2	0.3	0.8	0.9	0.1	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.2	-1.1	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.7	0.2	0.2
Whole body fat mass	0.2	0.9	2.1	0.2	1.4	0.8
Illnesses of father: Heart disease	0.2	0.3	0.7	0.5	0.3	-0.8
Arm fat percentage (left)	0.2	0.6	1.0	-1.0	1.0	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.7	0.6	-0.2
Qualifications: nursing, teaching	0.2	0.2	0.6	0.4	0.1	-0.8
Medication: Aspirin	0.2	0.3	0.6	-0.2	0.5	-0.7
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.2	-0.6	-0.9
Leg fat percentage (left)	0.2	0.7	0.9	-1.0	0.5	-0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.5	0.3	0.7
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.2	0.9	-0.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	-0.1	0.4	0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.4	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	-0.4	-0.3
Blood Eosinophil Count	0.1	0.5	1.4	1.2	-0.3	-0.3
Blood Red Count	0.1	0.9	1.9	-0.9	0.2	-1.4
Systolic Blood Pressure	0.1	0.7	1.7	0.4	0.5	-1.3
Respiratory disease	0.1	0.3	0.3	0.5	-0.6	0.6
Tanning	0.1	1.5	3.0	1.7	1.1	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.7	-0.2	0.1
Average weekly fortified wine intake	0.1	0.1	0.4	0.2	0.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	0.1	-0.1
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.2	0.4	0.6
Waist circumference	0.1	0.4	0.7	-0.0	0.8	0.7
Nervous feelings	0.1	0.2	0.5	-0.2	-0.7	-0.4
Neuroticism score	0.1	0.1	0.3	-0.2	-0.5	-0.1
Father’s age at death	0.1	0.1	0.2	0.2	-0.4	0.1
Worrier / anxious feelings	0.1	0.2	0.3	-0.2	-0.5	-0.6
Arm fat mass (right)	0.1	0.4	1.0	0.0	1.0	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.1	0.3	-0.3
Headache pain in last month	0.1	0.1	0.1	0.3	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.5	0.5	0.4
Leg fat percentage (right)	0.1	0.4	0.7	-0.8	0.3	-0.7
Leg fat mass (right)	0.1	0.2	0.4	0.2	0.6	-0.4
Medication: Aspirin	0.1	0.2	0.5	-0.1	0.7	-0.2
Smoking status: Previous	0.1	0.1	0.2	0.3	-0.3	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	-0.1	-0.2	-0.7
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	-0.0	0.5
Osteoarthritis (self-reported)	0.1	0.2	0.2	-0.5	0.4	0.3
Arm fat mass (left)	0.1	0.5	1.3	-0.1	1.2	0.4
Supplements: Calcium	0.1	0.2	0.3	-0.6	-0.4	0.1
Leg fat mass (left)	0.1	0.4	1.0	0.1	1.0	-0.5
Neuroticism	0.0	0.0	0.1	0.2	-0.0	-0.2
Hair Pigment	0.0	0.8	1.8	0.5	-0.4	-1.4
Migraine (self-reported)	0.0	0.0	0.1	0.0	-0.2	0.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.1	-0.2	-0.4
Family relationship satisfaction	0.0	0.0	0.1	-0.0	-0.0	-0.3

Hub : Genes

SLC16A6

Models

Trait associations