Hub : Genes

SLC1A4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1440	0.0390	5.6e-05	0.051	0.038	0.064	0.063	0.062	7.9e-07	2.0e-05	3.1e-08	3.9e-08	4.9e-08
2	GTEx	Artery Tibial	0.2061	0.0506	6.3e-06	0.025	NA	0.069	NA	0.080	4.1e-03	NA	4.3e-06	NA	8.1e-07
3	GTEx	Brain Cerebellum	0.3540	0.0940	6.7e-04	0.150	NA	0.122	NA	0.198	3.5e-05	NA	1.8e-04	NA	1.7e-06
4	GTEx	Cells Transformed fibroblasts	0.4400	0.0510	2.0e-13	0.414	NA	0.394	NA	0.402	2.6e-33	NA	2.4e-31	NA	4.6e-32
5	GTEx	Colon Sigmoid	0.1930	0.0710	5.3e-03	0.147	NA	0.023	NA	0.078	7.0e-06	NA	5.3e-02	NA	1.0e-03
6	GTEx	Esophagus Muscularis	0.2960	0.0740	1.1e-04	0.025	NA	0.065	NA	0.103	1.1e-02	NA	8.3e-05	NA	7.7e-07
7	GTEx	Heart Left Ventricle	0.1824	0.0665	6.6e-03	0.160	NA	0.203	NA	0.179	7.4e-09	NA	4.6e-11	NA	7.8e-10
8	GTEx	Muscle Skeletal	0.2049	0.0439	5.7e-07	0.118	NA	0.107	NA	0.101	1.2e-11	NA	1.3e-10	NA	4.3e-10
9	GTEx	Prostate	0.5890	0.1100	1.7e-04	0.007	NA	0.060	NA	0.049	2.1e-01	NA	1.3e-02	NA	2.3e-02
10	GTEx	Testis	0.1970	0.0790	6.6e-03	-0.002	NA	0.009	NA	-0.006	4.3e-01	NA	1.3e-01	NA	8.2e-01
11	NTR	Blood	0.0734	0.0182	1.3e-07	0.025	0.037	0.030	0.037	0.025	1.1e-08	6.4e-12	4.9e-10	4.0e-12	9.2e-09
12	ROSMAP	Brain Pre-frontal Cortex	0.1340	0.0322	9.8e-08	0.096	0.063	0.085	0.080	0.098	2.2e-12	1.4e-08	4.9e-11	1.7e-10	1.4e-12
13	YFS	Blood	0.0623	0.0159	2.5e-07	0.028	0.025	0.021	0.028	0.026	1.1e-09	1.1e-08	1.6e-07	9.4e-10	3.6e-09
14	TCGA	Bladder Urothelial Carcinoma	0.1040	0.0370	1.8e-06	0.106	0.056	0.053	NA	0.098	2.8e-09	1.6e-05	2.6e-05	NA	1.1e-08
15	TCGA	Breast Invasive Carcinoma	0.0483	0.0174	2.9e-06	0.032	0.022	0.025	NA	0.028	2.7e-07	2.1e-05	5.1e-06	NA	1.3e-06
16	TCGA	Colon Adenocarcinoma	0.0870	0.0430	9.9e-03	-0.001	0.012	0.000	NA	0.009	3.5e-01	6.6e-02	3.4e-01	NA	9.7e-02
17	TCGA	Head and Neck Squamous Cell Carcinoma	0.0786	0.0317	3.5e-05	0.005	0.051	0.039	NA	0.036	8.3e-02	2.0e-06	3.0e-05	NA	6.0e-05
18	TCGA	Kidney Renal Clear Cell Carcinoma	0.0492	0.0241	4.5e-03	0.004	0.014	0.011	NA	0.003	9.9e-02	8.8e-03	1.7e-02	NA	1.4e-01
19	TCGA	Thyroid Carcinoma	0.0740	0.0320	1.5e-03	0.005	0.036	0.017	NA	0.010	8.9e-02	1.8e-04	7.9e-03	NA	3.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Bipolar Disorder (2018)	0.6	0.9	3.8	1.9	0.6	1.0	-0.8	1.2	0.3	-0.0	-0.1	-0.1	-0.7	0.9	1.9	0.6	-0.8	0.2	-0.5	1.3	0.4	1.3
Bipolar Disorder or Schizophrenia	0.4	1.0	3.8	0.7	1.8	1.1	-1.9	1.1	0.8	-0.3	-0.5	-0.3	-0.6	-0.2	1.2	-0.1	-1.9	0.4	-1.3	0.2	-0.0	0.5
Depressed Affect (Nagel 2018)	0.5	1.0	3.7	-0.1	0.7	-0.5	1.0	-1.5	-0.2	0.7	1.7	0.8	1.2	0.2	-0.9	0.5	1.1	-0.3	0.1	0.7	1.9	1.6
Depression (Nagel 2018)	0.4	0.6	4.3	-0.4	-0.6	0.0	-0.2	-2.1	0.9	1.1	-0.3	-0.1	0.9	0.2	-0.5	0.3	-0.2	-1.1	-1.4	-0.3	-0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	9.2	1.2	-3.0	-0.0	1.6	-1.6	-1.5	-0.3	-0.1	-1.8	-1.4	-0.2	0.5	0.7	1.3	1.0	1.2	0.2	-1.0	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.7	0.0	-0.4	0.2	0.8	-0.9	0.0	1.1	1.1	1.3	0.7	-0.0	-0.5	0.1	0.7	-0.6	0.1	0.6	0.6	0.9
Schizophrenia (2018)	0.4	0.9	3.4	-0.7	1.8	0.5	-1.8	0.5	0.7	-0.3	-0.8	-0.3	-0.4	-1.1	-0.0	-0.6	-1.8	0.2	-1.2	-0.9	-0.4	-0.6
Schizophrenia vs Biploar Disorder	1.4	1.9	5.8	-1.9	2.0	-1.3	-0.9	2.4	1.4	0.7	1.5	1.7	0.6	-0.1	-2.0	-0.4	-0.9	-1.7	-1.2	-1.4	0.7	-0.2
Worry (Nagel 2018)	0.3	0.7	2.7	-0.8	0.2	-0.3	-0.4	1.0	0.6	0.3	1.0	1.7	0.9	-1.2	-0.8	-1.2	-0.6	-0.3	-0.8	-0.2	-0.9	-0.5
Alzheimer’s Disease (in mother)	2.0	2.4	7.2	-1.5	-0.7	-1.9	1.0	2.4	-1.2	-2.4	2.7	-0.1	-0.7	-2.2	-1.9	-1.8	1.0	1.3	1.1	0.1	-1.0	-0.4
Alzheimer’s Disease (in father)	1.8	1.9	7.7	1.4	-2.1	1.1	1.8	0.3	-2.8	-0.5	0.0	-0.8	-0.6	1.4	0.6	1.8	1.9	0.6	1.2	1.6	0.8	1.7
Alzheimer’s Disease (including proxy)	1.2	1.7	5.6	1.1	-1.8	-0.8	2.1	0.7	-2.4	-0.9	1.6	-0.4	-0.5	-0.6	0.5	0.5	2.3	0.7	2.0	0.9	0.5	1.2
Crohns Disease (2017)	0.4	0.9	3.3	-0.9	0.0	0.4	0.4	-0.9	1.5	1.6	-0.7	-0.9	1.7	-0.1	-1.1	0.5	0.5	-1.8	0.4	-0.5	0.6	-0.1
Irritable Bowel Disease (IBD)	0.6	1.4	4.6	-1.2	-0.5	-0.3	1.3	-0.1	1.4	1.5	0.1	-1.3	2.0	-0.2	-1.8	-0.1	1.3	-2.1	1.5	0.5	0.8	0.1
Ulcerative Colitis (UC)	0.7	1.3	4.3	-0.5	-0.9	-1.0	1.6	0.4	1.1	1.6	0.6	-0.8	0.7	-0.1	-1.2	-0.5	1.6	-2.1	2.0	0.9	0.7	0.1
Major Depression (MDD)	0.8	1.0	4.6	1.3	1.0	1.0	0.2	0.1	0.2	0.2	-0.4	0.1	1.5	0.6	1.4	0.7	0.1	1.0	0.2	0.5	1.9	2.1
Reaction Time	1.1	2.1	7.4	2.7	-0.0	1.4	0.4	0.7	-0.5	1.0	-0.4	2.1	-0.4	1.9	2.6	1.8	0.5	-0.3	-0.0	1.8	1.6	1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	4.3	-0.8	-2.1	-0.5	1.0	-0.4	-0.5	-0.2	0.7	-0.6	-1.4	-0.8	-1.1	-0.7	0.9	0.2	0.7	-0.4	-1.2	-0.9
Breast Cancer	1.0	2.3	8.0	-1.2	1.4	-2.7	-0.5	2.8	1.0	0.3	1.1	0.5	-0.7	-2.8	-1.0	-1.4	-0.3	-1.2	-0.7	-2.1	-0.4	-2.1
Ovarian Cancer	0.3	0.4	1.2	1.0	0.5	-0.5	-0.6	-0.9	0.6	0.6	0.8	1.1	0.2	0.4	0.9	0.5	-0.8	-0.1	-0.7	0.2	0.5	0.7
Prostate Cancer	0.6	0.9	4.2	-1.1	-1.4	0.7	0.1	0.7	0.6	-0.2	0.0	-0.4	-1.4	2.0	-1.4	0.1	0.2	-0.6	-0.3	1.0	-1.6	-0.6
Age at First Birth	0.4	0.5	1.7	0.8	-0.7	0.7	-0.3	-0.5	0.1	1.2	-1.0	0.3	-1.3	-0.2	0.6	0.8	-0.3	-1.3	-0.4	-0.2	-0.9	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.7	0.0	0.0	0.8	0.0	0.0	0.3	0.0	0.0	0.0	-0.2	-0.2	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-1.3	0.8	-0.2	-0.0	-1.0	-1.1	-0.1	-0.3	-0.9	0.2	-0.5	-0.8	-0.1	-0.0	-0.0	0.5	-0.4	0.6	-0.2
Coronary Artery Disease (CAD)	0.8	0.9	2.6	0.8	-1.1	0.5	1.2	-1.5	-1.6	-0.5	-1.1	-0.2	0.7	0.1	0.8	0.8	1.3	0.8	1.1	1.0	0.4	0.9
Crohns Disease (2012)	0.9	1.5	9.1	-0.2	0.2	-0.7	0.3	-0.7	2.0	2.9	1.1	-0.9	1.3	-0.5	-0.9	-0.2	0.5	-3.0	0.4	-0.3	0.1	-0.6
Mean Putamen Volume	0.7	0.8	2.7	1.4	-0.5	0.4	0.5	1.5	0.2	0.4	-0.9	1.1	-1.6	1.0	1.5	0.3	0.3	-0.4	0.8	0.6	0.0	0.5
Fasting Glucose	0.5	0.6	1.8	-1.4	0.9	-0.4	-0.2	0.8	-0.3	-0.8	0.4	-1.1	0.4	-0.9	-0.9	-0.6	-0.6	0.6	-0.4	-1.2	0.3	-0.4
HbA1C	1.0	1.1	4.7	1.1	0.9	0.5	0.3	0.6	0.5	1.2	-1.3	0.2	0.9	1.0	1.0	1.6	0.5	-1.0	1.2	0.1	2.2	1.0
HDL Cholesterol	0.8	1.3	6.8	1.5	-1.8	1.8	0.2	-2.6	0.0	1.0	-0.1	-0.1	0.1	1.2	1.4	1.1	0.2	-0.4	0.0	1.5	-1.0	0.3
LDL Cholesterol	0.8	1.2	3.6	1.1	1.1	1.2	-1.6	-1.9	0.8	1.3	-0.0	0.4	0.4	1.3	1.1	1.2	-1.6	-0.4	-1.8	0.3	0.2	0.1
Lupus	1.5	2.2	8.6	0.4	-0.5	-0.0	0.2	-2.9	2.8	2.7	-2.3	0.9	1.3	2.0	0.4	-0.2	0.4	-1.9	0.5	-0.9	-0.2	-0.8
Neuroticism (2016)	0.3	0.4	1.8	-0.5	0.2	1.4	-0.1	-0.8	-0.6	-0.6	0.3	0.7	0.6	0.6	-0.3	-0.1	0.3	0.4	0.1	1.1	-0.1	1.0
Primary Biliary Cirrhosis	1.1	1.5	4.9	1.3	-1.9	-0.1	1.3	-2.2	0.0	2.2	-0.8	-0.3	1.3	-0.4	0.8	-0.2	1.2	-1.8	1.9	-0.2	-0.2	-0.4
Rheumatoid Arthritis	0.7	1.0	7.1	-0.9	-0.6	0.6	0.2	-0.1	1.1	0.5	-0.5	2.7	-2.4	0.7	-0.8	0.2	0.2	-0.8	-0.6	0.3	-0.4	-0.3
Schizophrenia (2014)	0.2	0.5	2.0	-0.5	1.2	0.5	-1.4	1.1	0.3	-0.6	-0.2	0.5	-1.0	-0.5	-0.2	-0.2	-1.4	0.1	-0.9	-0.4	-0.1	-0.0
Triglycerides	0.6	1.1	3.1	-0.4	1.7	-1.6	-1.0	0.2	0.9	0.8	0.7	0.0	1.1	-1.0	-0.7	0.3	-1.1	-0.7	-1.8	-1.8	0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	-0.0	-0.1	-1.3	0.6	0.9	0.2	0.6	1.2	-0.4	0.8	-0.5	-0.2	0.3	0.6	-0.7	0.2	-1.0	1.7	0.4
Ulcerative Colitis	0.7	1.1	3.3	-0.8	-0.7	-0.9	1.5	-0.4	1.1	1.5	0.7	-0.7	0.9	-0.3	-1.1	-0.7	1.4	-1.8	1.7	0.7	0.5	0.1
Blood Eosinophil Count	0.4	3.2	12.0	-1.4	-1.6	-0.1	2.1	3.5	-1.9	-1.0	0.3	2.6	-3.0	2.5	-1.9	-1.0	1.9	0.3	1.5	1.6	-0.1	0.4
Blood Platelet Count	0.4	4.2	45.8	-0.6	-1.6	1.8	1.0	-6.8	-2.4	0.8	0.8	1.2	1.4	0.2	-1.5	2.3	0.9	1.2	-0.5	1.8	0.5	1.8
Blood Red Count	0.3	3.0	22.4	1.4	-2.7	0.9	1.4	-4.7	-0.4	0.9	-1.0	-1.2	1.1	3.3	1.2	1.0	1.4	0.5	1.3	1.0	0.0	0.5
Blood White Count	0.3	1.9	10.3	0.9	-0.4	-0.4	1.3	-3.2	0.2	1.5	-0.2	2.2	0.5	2.7	0.4	-0.1	1.2	-0.6	1.4	0.9	1.6	1.4
Heel T-Score	0.2	1.3	13.9	0.3	0.0	-0.0	0.0	3.7	-0.3	-1.6	-1.0	-0.3	1.2	-0.6	0.5	0.9	0.0	0.4	0.0	-0.5	1.7	1.1
BMI	0.2	1.4	6.8	-2.4	1.5	-0.8	-0.7	-1.6	-0.8	-0.7	-0.1	0.2	0.8	-2.6	-1.5	-0.9	-0.7	-0.2	0.3	-1.2	0.0	-1.1
Height	0.2	3.6	16.6	-0.4	-1.5	0.5	-1.8	-2.4	0.7	-1.2	-1.4	-2.5	-0.1	-1.1	0.6	-2.8	-1.9	1.4	-0.9	-2.5	-4.1	-2.8
Waist Hip Ratio (WHR)	0.4	1.6	3.8	-1.5	1.4	-1.5	-1.5	1.1	1.6	-0.3	0.6	0.2	0.2	0.1	-1.0	-1.9	-1.5	0.0	-1.6	-1.9	-1.5	-1.3
Systolic Blood Pressure	0.8	4.2	16.0	0.8	3.5	-3.5	0.2	2.7	0.2	0.7	1.9	-2.6	3.1	-0.4	0.7	0.4	0.2	-0.6	-0.6	-2.4	4.0	1.9
Smoking Status	1.3	3.0	7.4	-0.6	1.9	-1.7	-2.1	-1.3	1.8	1.7	0.2	1.4	-0.9	-1.7	0.9	-2.2	-2.0	-1.4	-1.2	-2.6	-2.3	-2.7
Allergy or Eczema	0.6	1.6	10.8	-1.3	-1.3	0.9	1.2	2.3	0.5	-0.3	0.2	-1.7	-3.3	1.2	-1.6	-0.4	1.1	-0.2	0.1	0.5	-0.3	-0.2
Cardiovascular Disease	0.5	1.5	5.3	-1.5	2.2	-2.3	-0.1	0.7	-0.4	-1.2	1.0	-1.4	1.3	-0.7	-1.1	-0.7	-0.2	-0.0	-0.1	-2.1	1.7	0.6
Hypothyroidism (self reported)	0.9	2.1	8.0	0.4	-0.5	-0.1	1.9	-0.3	-1.8	0.4	1.1	0.5	0.4	1.3	-0.3	1.1	2.0	0.1	2.5	1.8	2.6	2.8
Respiratory disease	0.7	1.5	3.4	-1.2	0.3	-0.7	-0.8	1.7	1.8	1.1	1.2	0.2	-1.1	0.9	0.1	-1.6	-0.8	-1.1	-1.3	-1.1	-1.8	-1.9
Type 2 Diabetes (T2D) (2018)	1.2	2.2	8.3	-0.2	1.7	-2.0	-1.2	-1.2	-0.3	-0.6	1.1	-0.8	2.7	-2.9	0.1	-0.5	-1.3	0.7	-1.5	-2.7	0.5	-0.8
Lung FEV1/FVC ratio	0.6	2.8	25.7	0.6	0.2	-1.3	1.5	-1.4	-1.1	0.8	0.5	5.1	-2.0	-0.8	-0.9	0.8	1.4	-0.8	1.4	0.6	2.5	1.4
Lung FVC	0.6	2.8	13.2	0.9	-1.2	2.4	0.5	2.4	-1.8	-1.4	-2.4	-0.5	0.5	3.6	1.1	1.6	0.6	1.1	1.2	1.6	1.4	1.8
Neuroticism	0.2	0.5	1.9	-0.3	0.5	-0.6	-0.2	-0.7	0.5	0.6	1.4	0.7	1.1	-0.7	-0.4	-1.1	-0.2	-0.4	-0.2	-0.3	-0.8	-0.2
Chronotype (morning person)	1.2	2.8	9.9	-1.0	0.9	-0.9	-2.5	2.3	2.8	0.0	1.2	0.4	1.0	-0.2	0.2	-1.1	-2.4	-0.4	-3.1	-1.3	-2.4	-2.1
Hair Pigment	0.2	5.8	14.9	-0.3	2.2	-2.1	-3.3	-1.9	3.1	1.9	1.8	1.9	0.5	-3.4	0.6	-1.8	-3.2	-0.5	-3.9	-3.1	-2.9	-2.9
Tanning	0.2	1.9	7.0	-0.3	0.0	-2.6	0.5	-0.7	0.7	1.7	2.6	0.6	1.6	-1.1	-0.8	-2.6	0.5	-1.6	1.0	-0.7	-0.9	-1.4
Hand grip strength (left)	0.9	2.3	6.1	-1.0	2.2	-0.0	-2.3	2.5	0.6	-1.7	-0.7	-1.3	2.3	-1.5	0.1	-0.7	-2.1	0.1	-1.4	-2.4	-0.6	-0.6
Number of treatments/medications taken	0.4	0.8	2.3	-1.1	-0.4	-1.4	1.5	-0.6	0.5	0.4	-0.3	-0.5	0.7	0.7	-0.3	-0.2	1.5	-0.9	1.3	-0.8	1.1	0.4
Average weekly spirits intake	0.6	0.8	4.0	1.3	0.8	1.5	-0.5	-1.3	-0.4	0.1	-0.8	-0.2	0.4	0.1	2.0	1.0	-0.5	0.8	-0.1	0.2	0.5	0.7
Sensitivity / hurt feelings	0.4	0.7	3.6	-0.7	-1.3	0.1	0.6	-0.1	0.7	1.2	-0.7	1.9	-0.7	0.3	-1.0	-0.4	0.6	-1.2	0.7	-0.5	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.1	-0.1	1.2	-1.0	-0.3	-1.2	-0.1	0.0	1.0	-0.1	1.8	-0.6	-0.5	0.3	-0.3	-0.1	-0.7	-0.1	1.1	0.8
Hearing difficulty/problems: Yes	1.0	1.5	5.0	-1.9	0.5	-1.9	-0.0	-1.7	-0.3	-0.4	2.2	0.6	0.1	-2.2	-1.7	-1.7	-0.1	0.7	-0.4	-0.7	-0.5	-0.4
Relative age of first facial hair	1.3	2.8	12.8	-2.3	-0.2	-0.6	-1.9	0.1	2.3	0.7	0.4	1.1	0.1	0.3	-1.9	-2.1	-2.0	-1.2	-2.0	-0.7	-3.6	-2.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.3	-1.2	0.4	-2.1	1.2	-1.4	-0.2	-0.3	2.0	-0.9	1.8	-1.0	-2.0	-1.1	1.1	0.7	1.4	-0.1	1.4	0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.4	1.5	-0.7	-1.0	0.4	-1.2	0.9	2.1	0.8	2.1	-0.3	0.4	0.8	0.0	0.4	-1.4	0.2	0.2	-0.6	-0.3
Ever had hysterectomy (womb removed)	2.2	2.5	6.3	0.3	1.7	-1.0	-2.5	-1.0	2.3	1.9	-0.4	-0.6	-0.1	-0.2	1.4	-0.9	-2.4	-1.5	-1.8	-2.4	-1.3	-2.0
Systolic blood pressure, automated reading	0.9	2.6	12.8	0.2	3.6	-2.7	-0.9	0.6	1.2	1.4	1.9	-1.9	1.3	-1.2	0.7	0.5	-0.9	-0.6	-1.3	-2.0	2.6	1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	4.1	-0.8	0.3	-1.0	-0.6	-0.6	1.4	1.1	-0.9	-0.4	1.0	-0.8	-0.4	-1.1	-0.8	-1.0	-0.5	-2.0	-0.8	-1.1
Angina	0.7	1.0	2.3	-1.4	-0.2	-1.0	1.0	0.9	-0.3	-1.1	1.0	-1.4	0.9	-1.1	-1.2	-0.8	1.1	1.5	0.9	-0.2	0.7	0.2
Medication for hormone replacement therapy	1.9	2.1	6.1	0.5	-2.3	-1.1	2.5	1.0	-1.9	-0.7	1.7	0.8	-0.8	-1.4	-0.7	-1.2	2.4	0.9	2.4	0.8	-0.8	-0.3
Vitamin and mineral supplements	0.3	0.4	1.8	-0.9	-0.1	0.1	0.5	0.1	-0.7	-0.8	0.4	-0.3	-0.6	-0.7	-0.9	-0.3	0.5	1.3	0.8	0.3	0.0	0.0
Supplements: Zinc	0.3	0.3	1.4	0.7	-0.1	0.7	-0.4	0.1	-0.3	0.0	-0.2	0.9	-1.0	0.7	1.2	0.3	-0.3	0.0	-0.4	0.3	-0.1	0.6
Medication: Co-codamol	1.2	1.4	6.1	-1.0	0.2	-2.5	0.2	-0.5	1.2	0.8	-0.0	0.4	1.6	-1.4	-0.9	-1.6	0.1	-1.7	-0.1	-1.9	-0.5	-1.8
Medication: Metformin	1.5	2.1	12.8	-1.3	0.8	-2.2	-0.2	-0.5	-1.0	-1.2	0.5	-0.7	2.3	-3.6	-0.6	-1.1	-0.4	1.1	-0.3	-2.1	-0.5	-1.8
Diabetes (father)	0.8	0.9	5.8	0.2	-0.2	-1.0	1.2	-2.4	-1.6	-0.4	1.6	-0.4	0.4	-1.0	-0.0	0.4	1.2	0.9	0.6	0.2	0.7	-0.0
Diabetes (mother)	0.7	0.8	5.3	-0.6	0.5	-1.4	0.8	0.1	-1.1	-0.3	1.2	-2.3	-0.5	-1.2	-1.2	0.1	0.8	-0.4	0.4	-0.5	0.6	-0.1
Severe depression (siblings)	0.7	0.8	4.2	1.9	0.9	-0.2	-1.1	0.1	0.1	0.6	0.2	1.6	-0.0	0.1	2.0	0.5	-1.0	0.1	-1.3	0.1	0.0	0.2
Pack years adult smoking proportion	0.8	1.2	4.2	-2.0	0.5	-1.3	-0.6	-0.2	-1.4	-1.4	0.4	0.6	0.4	-1.3	-1.8	-0.7	-0.6	0.6	-0.9	-1.4	-0.7	-1.6
Impedance of leg (right)	0.3	1.5	8.1	1.0	-2.3	0.1	0.5	1.2	-0.4	-0.5	-0.1	1.2	-2.8	0.5	0.7	-0.4	0.5	0.9	-0.5	0.8	-2.5	-1.0
Leg fat-free mass (left)	0.2	1.2	4.0	-1.5	0.9	-0.3	-0.6	-1.6	0.1	-0.2	0.4	-1.6	2.0	-1.7	-0.9	-1.1	-0.5	-0.1	0.4	-1.5	-0.1	-1.1
Trunk fat percentage	0.2	0.9	6.6	-2.6	0.4	-0.9	-0.1	-1.0	-0.2	-0.6	-0.1	-0.1	-0.4	-1.6	-1.9	-0.2	-0.1	-0.1	-0.2	-0.5	-0.5	-1.1
Hand grip strength (right)	0.7	1.8	5.8	-0.4	1.4	0.4	-2.3	2.1	0.6	-1.1	-1.0	-1.7	0.6	-1.1	0.6	-0.2	-2.1	-0.0	-1.5	-2.4	-1.1	-1.0
Townsend deprivation index at recruitment	0.7	1.0	4.3	0.7	1.0	0.2	0.6	-2.1	-0.8	-0.0	-1.4	1.1	0.4	1.0	1.0	0.8	0.7	0.1	1.4	0.5	1.7	1.2
Current tobacco smoking	0.2	0.4	1.5	-0.6	0.2	-1.2	0.3	-0.7	-0.9	-0.3	0.1	-0.4	0.2	-1.2	-0.1	-0.6	0.3	0.4	0.6	-1.1	-0.1	-0.6
Average weekly fortified wine intake	0.9	1.0	4.4	0.4	0.1	-0.6	-0.1	0.2	1.9	2.1	0.3	-1.2	1.2	-0.4	0.5	-1.7	0.1	-1.5	1.1	-0.7	0.6	0.0
Maternal smoking around birth	1.0	1.4	4.8	-0.8	0.6	-2.2	-0.6	-1.2	1.0	1.2	1.6	1.8	0.8	-0.5	-0.1	-1.4	-0.6	-1.3	-0.7	-0.8	-0.9	-1.8
Fed-up feelings	0.5	0.8	4.9	1.0	1.2	-0.6	0.4	-1.0	0.3	0.8	0.9	0.3	2.2	-0.1	0.6	0.3	0.4	-0.4	0.3	0.3	1.8	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	3.5	-1.4	0.1	-0.3	-0.4	-1.9	0.4	0.1	-0.1	-0.2	1.4	0.1	-1.4	0.5	-0.3	-0.9	-1.3	-1.0	0.1	0.1
Relative age voice broke	0.8	1.2	9.2	-0.9	-1.9	0.5	-0.4	-0.6	0.1	-0.6	-0.0	-0.7	-0.2	-1.1	-0.6	-1.2	-0.6	0.9	-0.7	-0.3	-3.0	-1.5
Taking other prescription medications	0.3	0.5	1.7	-1.0	0.3	-0.1	0.8	-1.3	-0.0	0.3	0.4	0.9	0.9	0.2	-0.4	0.5	0.8	0.0	0.7	0.1	1.1	1.2
Age when periods started (menarche)	0.2	0.6	1.7	1.0	-0.6	0.8	0.2	1.0	1.3	1.2	1.2	-0.4	-0.4	0.4	1.0	-0.1	0.2	-0.6	-0.2	1.0	-0.4	-0.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	6.3	2.5	-1.4	1.4	1.0	-1.9	-0.8	0.7	-0.8	-0.7	0.5	1.3	2.1	1.8	1.0	0.7	1.1	1.2	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	8.5	0.1	1.3	0.2	-1.8	2.9	1.1	-0.9	-1.0	0.9	-0.0	-1.0	0.6	-0.7	-1.8	-0.1	-1.4	-1.1	-0.3	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	-0.3	-0.4	-0.5	0.3	-0.4	-0.1	0.1	1.1	0.4	-1.0	-1.0	-0.1	1.2	0.3	0.2	-0.2	0.3	-0.3	0.2
Qualifications: CSEs or equivalent	0.3	0.3	0.9	-0.8	0.7	0.5	0.1	0.8	0.1	-0.7	0.6	-1.0	0.3	-0.2	-0.8	-0.5	0.0	-0.3	1.0	0.9	0.0	-0.1
Serious illness, injury or assault to yourself	0.6	0.7	3.0	1.1	0.4	-0.6	-0.1	-0.4	0.7	1.4	-0.8	-1.4	1.7	-0.3	1.1	0.0	-0.1	-0.4	-0.0	-1.0	0.2	-0.6
High blood pressure	0.7	2.1	10.4	-2.2	1.6	-3.2	-0.8	1.2	0.7	-1.1	0.4	-0.2	-0.2	-1.0	-1.8	-1.3	-1.0	-0.6	-0.9	-2.8	0.1	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.8	-0.6	0.1	-0.3	0.4	2.0	1.4	1.1	0.4	-0.4	-2.2	0.6	-0.7	-0.6	0.4	-1.2	-0.1	-0.3	-0.1	-0.6
Multivitamins +/- minerals	0.3	0.4	1.6	0.5	0.3	0.1	-0.7	-0.3	0.7	0.8	-0.2	0.2	0.2	0.3	0.7	0.3	-0.7	-1.3	-1.2	-0.5	-0.1	-0.1
Stomach or abdominal pain in last month	0.8	1.0	3.9	-0.2	-0.5	-1.0	1.3	-0.8	-2.0	-1.4	1.6	-0.1	0.3	-1.1	-0.8	-0.7	1.5	1.2	0.6	0.2	-0.1	-0.2
Supplements: Glucosamine	0.6	0.8	6.7	-0.8	0.5	-0.2	-0.6	-2.6	0.7	0.6	-1.5	-0.8	-0.7	-0.6	-0.8	0.5	-0.7	-0.9	-0.6	-0.9	0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	0.1	-0.8	-1.2	1.0	0.9	-0.9	-0.1	0.5	-1.0	-0.7	-1.3	-0.3	-0.7	1.1	-0.3	1.2	-0.2	-0.2	-0.3
Medication: Atenolol	1.0	1.3	3.0	-1.7	1.1	-1.3	-1.2	-0.6	1.7	0.1	1.4	0.9	1.0	-0.9	-1.0	-1.4	-1.1	-0.4	-1.3	-1.0	-1.2	-0.8
Medication: Levothyroxine sodium	0.3	0.6	2.2	-0.0	-0.2	-0.3	1.0	0.5	-1.0	0.3	0.9	0.0	0.6	0.5	-0.6	0.6	1.1	-0.1	0.9	0.8	1.0	1.5
Sitting height	0.1	0.5	2.3	0.3	-1.5	1.1	0.3	-0.6	0.2	-0.6	-0.6	-1.2	-0.0	0.2	0.2	-1.0	0.3	0.8	0.6	-1.0	-0.8	-0.3
Chronic bronchitis/emphysema (father)	0.7	0.8	2.2	-0.2	1.5	1.3	-1.4	0.9	0.4	-0.9	-0.6	0.6	-0.0	1.4	0.3	0.7	-1.4	0.8	-1.0	0.5	-0.1	0.4
High blood pressure (mother)	0.3	0.4	2.1	-0.8	0.3	-0.4	0.0	-0.0	-0.6	-1.1	0.6	-0.9	0.8	-1.4	-0.8	-0.4	0.0	0.5	0.2	0.0	-0.1	0.2
Body mass index (BMI)	0.3	1.4	7.1	-2.7	2.3	-0.5	-0.8	-1.1	-0.3	-0.7	0.1	0.2	1.6	-1.3	-1.8	0.5	-0.9	0.0	-0.6	-0.5	1.2	-0.1
Impedance of leg (left)	0.3	1.7	9.4	0.6	-2.0	0.1	0.2	2.4	-0.5	-0.9	0.2	1.1	-3.1	0.5	0.3	-0.6	0.2	1.0	-0.9	0.7	-2.5	-0.8
Leg predicted mass (left)	0.2	1.2	4.2	-1.6	0.9	-0.4	-0.6	-1.6	0.2	-0.2	0.3	-1.5	2.0	-1.7	-1.0	-1.2	-0.6	-0.2	0.4	-1.6	-0.2	-1.2
Trunk fat mass	0.3	1.2	7.2	-2.7	1.0	-0.8	-0.8	-1.4	0.1	-0.7	-0.2	-0.4	0.4	-1.7	-1.7	-0.5	-0.8	0.1	-0.5	-1.2	-0.6	-1.5
Waist circumference	0.5	2.0	9.1	-3.0	2.5	-0.8	-1.5	-1.5	0.4	-0.7	0.6	-0.0	1.6	-1.5	-1.9	-0.8	-1.6	0.4	-1.2	-1.3	0.0	-1.1
Number of incorrect matches in round	0.4	0.6	2.4	0.3	1.1	-0.3	-1.6	-0.3	-0.2	-1.0	0.5	1.0	0.1	-0.2	0.8	0.8	-1.6	0.3	-1.3	-0.2	-0.2	0.5
Past tobacco smoking	1.4	2.6	6.8	1.8	-1.3	1.3	2.2	0.4	-1.4	-0.4	-0.5	-0.6	1.6	1.5	0.6	2.1	2.2	0.4	1.7	2.0	2.6	2.6
Alcohol usually taken with meals	0.7	1.1	5.3	1.2	1.0	-1.0	0.3	-1.2	1.0	2.3	1.4	-1.0	1.5	0.2	0.5	0.9	0.5	-1.0	-0.1	0.1	1.5	0.7
Nervous feelings	0.2	0.4	2.2	0.5	-0.4	0.2	-0.3	1.5	0.9	0.8	-0.0	0.0	0.3	-0.4	0.6	-1.1	-0.3	-0.5	-0.1	-0.5	-0.3	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	3.2	-0.5	-0.1	-1.2	0.2	-1.8	1.0	1.5	0.9	-0.0	0.9	0.1	-0.4	-0.6	0.3	-1.3	-0.2	-0.6	0.1	0.0
Hearing difficulty/problems with background noise	0.7	1.2	4.9	-1.2	-1.8	-1.1	1.3	0.2	0.0	1.1	1.1	1.1	-2.2	-0.8	-1.4	-0.6	1.2	-0.9	0.8	0.3	-0.4	-0.4
Hair/balding pattern: Pattern 2	1.5	2.0	7.9	1.7	1.4	1.4	-0.7	-1.0	0.3	0.8	0.5	-0.1	0.9	2.2	1.4	2.2	-0.5	0.1	-0.7	1.1	2.8	2.4
Had menopause	0.3	0.4	1.5	0.4	0.1	0.5	-0.2	-1.2	0.3	0.7	-1.2	0.3	-0.1	0.7	0.7	1.0	-0.2	-0.1	-0.6	-0.7	0.3	0.3
Had other major operations	0.9	1.1	3.0	-0.2	-1.7	-0.2	1.5	-1.3	-1.4	-1.0	0.5	-1.3	-0.3	0.0	-1.1	-0.5	1.6	0.8	1.6	0.6	0.1	1.3
Forced vital capacity (FVC)	0.2	0.9	3.6	0.3	-1.1	0.9	-0.8	1.1	-0.3	-0.5	-1.6	-1.4	-0.4	0.9	0.9	-0.9	-0.7	0.2	0.5	-0.9	-1.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	12.2	0.0	1.2	-0.5	-1.6	3.5	1.4	0.1	0.5	0.8	-0.3	-1.0	0.3	-1.6	-1.6	-0.8	-1.4	-1.0	-0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.1	0.3	1.4	-0.6	-0.8	-0.8	0.4	0.2	0.6	0.2	1.2	0.6	0.1	0.4	-0.5	-0.3	-0.5	-0.7	1.1	0.4
Qualifications: None of the above	0.9	2.0	9.6	-3.1	2.5	-1.3	-1.2	-0.6	1.1	-0.4	0.3	0.2	0.9	-1.1	-2.7	-0.6	-1.2	-0.6	-1.0	-1.6	0.6	-0.4
Financial difficulties in last 2 years	0.6	0.9	2.7	0.4	1.4	0.0	-1.1	-0.8	0.2	-0.8	1.5	-1.1	0.7	-0.9	1.1	0.7	-1.1	1.6	-1.3	0.2	-0.1	0.2
Mouth/teeth dental problems	1.3	2.1	8.0	-0.4	2.3	0.8	-2.8	0.9	1.6	0.2	-1.1	1.9	1.3	0.5	0.6	-0.4	-2.7	-1.0	-1.8	-0.9	-0.9	-0.9
Heart attack	0.3	0.3	1.8	-1.4	-1.0	0.1	0.6	0.6	0.4	0.1	0.1	-0.1	-0.2	0.8	-0.9	-0.3	0.5	-0.4	0.3	-0.2	-0.3	0.5
Allergy	0.5	1.3	6.4	1.0	-0.4	0.6	0.2	-2.5	-1.9	-0.9	-1.0	0.5	1.8	-0.5	0.6	1.2	0.3	1.3	0.6	0.3	1.1	1.3
Pain all over the body in last month	0.7	0.8	6.9	-1.2	-0.4	0.7	0.4	2.6	0.0	-0.9	-0.3	-0.8	-0.7	0.1	-1.3	0.1	0.5	0.5	0.6	0.6	0.1	0.8
Diabetes (self-reported)	0.7	1.1	4.5	0.1	0.9	-0.9	-1.0	-1.5	-0.3	-0.0	0.0	-0.8	1.4	-2.1	0.9	-0.0	-1.1	0.7	-1.1	-2.0	0.0	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	4.2	-2.1	-0.9	0.4	0.0	1.1	-0.2	-0.4	0.3	-1.0	-0.5	-0.0	-1.4	-0.1	0.1	0.1	-1.0	0.7	-1.2	-0.5
Medication: Ramipril	0.9	1.2	7.0	-0.3	-1.0	-1.4	1.8	-0.0	-0.7	-0.0	0.3	-2.6	0.9	-0.0	-0.2	-0.9	1.8	0.1	1.4	-0.7	0.7	0.6
Medication: Simvastatin	0.2	0.3	2.0	-0.7	0.2	-0.8	0.1	-0.1	-0.1	-0.5	1.4	-1.0	-0.5	-0.3	-0.2	-0.5	0.0	0.9	-0.5	-0.2	-0.4	0.1
Fluid intelligence score	0.2	0.4	1.6	0.5	-0.8	0.9	-0.1	-0.7	0.7	1.0	-0.1	-0.3	-0.8	1.3	0.1	1.0	-0.3	-0.2	-0.5	0.1	-0.1	0.1
Illnesses of siblings	1.1	1.6	4.4	1.8	-1.0	2.0	1.0	1.1	-1.1	-1.2	-1.4	-0.2	-0.4	-0.3	1.9	0.4	1.0	2.1	1.7	1.1	0.6	0.9
Neuroticism score	0.2	0.4	2.6	0.6	0.6	-0.1	-0.1	-0.3	0.4	0.9	0.8	0.6	1.6	0.2	0.2	0.2	-0.1	-0.8	-0.4	-0.0	0.6	0.8
Weight	0.3	1.7	6.8	-2.6	1.7	-0.4	-1.6	-1.5	0.3	-0.8	0.0	-0.8	1.4	-1.6	-1.5	-0.6	-1.6	0.2	-1.0	-1.7	-0.5	-1.4
Impedance of arm (right)	0.4	1.9	11.0	1.1	-3.3	0.0	1.6	1.0	0.2	0.4	0.1	-0.9	-2.8	0.6	0.2	-0.9	1.8	-0.6	1.2	1.2	-1.9	-0.4
Arm fat percentage (right)	0.2	0.9	6.8	-2.6	1.2	-0.8	-0.3	-0.8	-0.1	-0.7	0.3	0.1	0.6	-1.3	-1.8	0.1	-0.3	-0.2	-0.3	-0.1	0.3	-0.5
Trunk fat-free mass	0.3	1.8	6.1	-1.2	1.7	0.1	-2.0	-1.1	0.7	-0.8	0.0	-1.5	2.5	-1.3	-0.0	-1.1	-2.0	0.7	-0.9	-2.3	-0.7	-1.3
Hip circumference	0.2	1.0	5.7	-1.6	1.6	-0.0	-1.1	-2.4	0.2	0.3	-0.0	-0.1	1.4	-1.2	-0.9	0.3	-1.0	-0.2	-0.6	-0.5	0.7	-0.5
Time employed in main current job	3.1	3.6	13.0	-1.8	3.6	-0.9	-3.0	0.9	2.0	0.5	0.4	1.1	2.0	-1.2	-1.0	-1.7	-3.0	-1.0	-2.5	-2.3	-0.6	-1.9
Alcohol intake versus 10 years previously	0.6	0.9	3.3	-0.7	-0.6	-1.8	0.7	-1.6	-0.5	-0.5	0.1	-0.4	1.1	-1.3	-0.3	-1.4	0.7	0.0	0.7	-1.0	-1.0	-1.5
Father’s age at death	1.6	2.1	6.2	1.7	-2.4	1.2	2.1	-0.1	-1.6	-0.4	-0.1	-0.8	-0.9	0.4	0.6	1.8	2.1	0.8	1.5	2.5	1.2	1.5
Worrier / anxious feelings	0.3	0.5	3.2	0.2	0.4	0.3	-0.3	-1.0	0.1	0.2	-0.2	1.8	1.5	0.9	-0.1	-0.1	-0.4	-0.3	-0.6	-0.2	0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	6.4	-1.4	-0.7	-1.6	1.6	0.2	-0.3	-0.5	1.5	-0.6	2.5	-0.9	-1.8	-0.6	1.8	-0.1	1.2	-0.1	0.7	0.6
Falls in the last year	1.3	1.8	9.1	-3.0	0.8	-1.1	-0.8	-0.6	0.3	-0.8	-0.4	-1.1	0.5	-1.5	-2.3	-1.8	-0.8	-0.0	-0.9	-1.3	-2.0	-1.5
Hair/balding pattern: Pattern 3	1.2	1.9	8.1	-1.2	-0.5	-1.4	0.6	0.3	-1.5	-2.2	-0.1	-0.7	-2.4	-2.8	-1.0	-1.3	0.4	1.5	0.6	-0.9	-1.2	-1.4
Number of live births	0.4	0.5	2.3	-0.1	-0.9	0.6	0.8	0.1	0.8	1.5	-0.4	-0.5	0.2	0.8	0.4	0.1	0.9	-1.3	0.6	0.4	0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	2.5	0.6	-1.0	0.7	0.0	0.8	-0.8	-0.3	-1.6	-0.1	-0.6	1.1	0.7	-0.1	0.2	-0.0	1.3	-0.4	-0.1	0.1
Pulse rate	0.9	1.5	7.5	0.4	-1.4	0.3	1.6	-2.7	-1.7	0.4	1.4	0.2	0.1	-0.3	0.1	-0.4	1.8	0.9	1.4	1.8	-0.5	0.5
Happiness	1.8	2.1	6.7	1.9	-0.3	-0.4	2.3	-0.6	-0.6	1.4	1.4	0.3	1.1	1.1	1.1	0.5	2.4	-0.7	1.8	1.7	2.6	2.1
Noisy workplace	1.7	2.1	8.8	0.4	-0.7	1.7	1.8	-1.7	-1.4	-2.0	-0.1	-0.4	0.4	-0.1	0.1	0.6	1.8	3.0	1.1	2.1	1.0	2.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	7.5	2.3	-2.7	0.2	2.7	0.7	-2.2	-0.4	1.6	-0.5	0.3	0.3	0.8	-0.5	2.7	1.2	1.9	1.8	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.3	1.3	1.1	-0.1	-0.7	-0.8	-0.0	0.3	-0.4	-0.1	1.5	0.5	0.9	0.6	-0.7	0.6	-1.3	-0.7	0.4	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.7	6.1	-1.6	-0.3	-1.8	-0.6	-2.5	0.8	0.4	-0.4	-1.6	-0.9	-1.7	-1.4	-0.7	-0.5	-0.6	-0.3	-2.2	-1.3	-1.8
Asthma	0.5	1.0	4.4	-0.6	0.2	-0.3	-0.7	2.1	0.9	0.2	0.8	-0.1	-1.3	1.4	0.1	-1.1	-0.8	-0.4	-1.2	-0.7	-1.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	8.9	0.8	-0.9	0.9	1.2	-3.0	-1.9	-0.9	0.4	-0.3	1.9	0.9	-0.3	1.2	1.2	1.4	0.5	1.4	1.0	1.3
Medication: Cholesterol lowering	0.6	1.0	4.5	-0.7	-0.5	-1.0	-0.0	0.3	0.8	0.4	-1.0	-1.7	-1.2	-0.3	0.9	-1.1	-0.2	-0.4	0.2	-2.1	-1.2	-1.4
Depression (self-reported)	0.5	0.6	3.5	-0.6	-0.6	0.1	0.9	-1.9	-1.6	-0.8	-0.3	-0.4	-0.6	-0.5	-0.7	0.8	0.9	0.5	0.0	0.5	0.0	-0.3
Medication: Lansoprazole	1.0	1.2	7.1	-0.1	-0.2	0.4	1.6	0.8	-0.7	-0.6	0.3	-2.7	1.2	-0.5	0.1	0.5	1.4	0.8	1.7	0.7	0.9	1.4
Prospective memory result	0.4	0.5	2.2	-1.0	0.4	0.2	0.6	-0.8	-0.3	0.3	-1.1	-0.4	-0.2	-0.2	-0.6	0.4	0.7	-0.8	1.5	0.7	1.2	0.5
Lung cancer (father)	1.3	1.5	7.0	-0.4	-0.0	-0.2	-1.0	-0.1	1.8	0.9	-1.4	2.6	1.1	1.2	0.3	-1.0	-1.0	-1.1	-1.0	-1.5	-1.5	-1.7
Illnesses of mother	1.2	1.5	3.7	1.2	1.1	1.5	-1.8	-0.2	1.3	0.5	-1.0	1.9	0.2	1.9	1.8	0.6	-1.8	0.3	-1.8	0.2	-0.0	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.5	0.9	-1.5	0.5	0.2	1.6	-0.7	-0.5	-1.6	-0.1	-0.6	0.9	1.0	-0.5	0.3	0.2	1.2	-0.7	-0.6	-0.3
Pulse wave Arterial Stiffness index	0.8	0.9	7.4	1.3	0.2	0.3	-0.1	-0.2	0.9	0.4	0.1	-0.6	2.7	0.2	1.8	1.2	-0.1	-0.1	0.3	0.3	0.7	1.0
Impedance of arm (left)	0.4	1.9	11.6	1.0	-3.2	-0.3	1.6	0.1	-0.4	0.4	0.3	-0.9	-3.4	0.0	-0.2	-0.7	1.7	-0.6	1.1	1.0	-1.8	-0.4
Arm fat mass (right)	0.3	1.4	7.7	-2.8	2.1	-0.8	-1.0	-1.1	0.0	-0.8	0.4	-0.2	1.5	-1.6	-1.8	-0.1	-1.0	-0.0	-0.8	-0.9	0.4	-0.8
Trunk predicted mass	0.3	1.9	6.2	-1.1	1.7	0.0	-2.0	-1.2	0.6	-0.7	0.1	-1.6	2.5	-1.4	0.0	-1.2	-2.0	0.7	-0.9	-2.2	-0.7	-1.3
Standing height	0.3	2.7	13.1	-0.2	-1.2	0.0	-1.7	-0.9	1.3	-0.2	-0.4	-2.3	-0.2	-0.9	0.3	-2.4	-1.6	0.2	-0.9	-2.9	-3.6	-2.9
Length of working week for main job	0.6	0.6	3.6	-0.1	0.1	0.8	0.2	-0.6	-0.4	-0.7	-0.0	-1.9	-1.6	0.5	-0.3	1.1	0.1	1.0	0.0	0.5	1.2	0.5
Exposure to tobacco smoke at home	1.4	1.6	7.0	0.1	0.4	0.4	1.1	-2.1	-1.8	-1.4	0.7	0.7	1.6	-0.5	-0.5	0.9	1.1	2.6	0.8	0.8	1.6	1.2
Breastfed as a baby	1.1	1.4	4.3	1.2	-2.1	1.1	1.7	-0.8	-0.3	0.6	-1.2	-0.4	0.1	1.5	0.1	1.5	1.7	-0.1	1.0	1.2	1.5	1.3
Tense / ‘highly strung’	0.5	0.8	1.8	-0.4	1.2	-1.3	-0.9	0.7	0.9	1.1	1.1	1.1	1.3	-0.9	-0.3	-0.7	-0.8	-0.8	-0.9	-1.0	0.2	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.1	0.8	-0.7	0.6	1.2	-2.0	-1.8	-0.5	-0.8	-1.6	0.2	-0.3	0.4	0.5	1.3	1.4	1.2	-0.4	1.3	1.2
Hair/balding pattern: Pattern 4	1.3	3.1	8.3	-0.1	1.2	-1.9	-1.9	0.8	2.9	1.8	-0.1	1.1	0.1	-0.7	1.0	-2.6	-1.9	-2.0	-1.5	-2.6	-2.1	-2.6
Birth weight of first child	0.3	0.5	3.0	-0.1	-0.5	-0.2	0.7	-1.7	0.5	1.4	0.6	-1.2	0.0	-0.3	-0.3	-0.5	0.6	-0.6	0.5	0.2	0.1	0.0
Peak expiratory flow (PEF)	0.7	1.5	5.5	-0.0	-1.3	0.7	1.7	-0.5	-2.3	-1.5	-0.5	1.4	0.1	-0.2	-0.4	0.7	1.8	1.3	2.0	1.5	1.1	1.2
Pulse wave reflection index	1.2	1.4	5.5	1.4	0.1	1.3	-1.5	1.8	0.8	-0.7	-2.4	-0.6	0.5	1.1	2.3	1.3	-1.5	-0.1	-0.7	-0.6	-0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.7	1.1	0.4	-0.5	-0.7	-0.7	1.6	1.5	0.9	0.7	1.1	-0.3	1.6	-0.7	-0.7	-0.6	-0.6	-0.9	-0.8	-0.5
Loud music exposure frequency	0.7	0.8	2.8	0.8	-1.7	0.7	1.2	-0.8	-1.5	-0.5	-0.2	-0.0	-1.2	0.3	0.4	0.3	1.1	0.6	1.1	0.6	0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	5.5	2.3	-1.4	0.3	1.1	0.0	-0.9	0.7	0.6	-0.7	0.9	0.5	1.2	-0.1	1.2	-0.3	0.7	1.2	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	3.3	4.3	16.9	1.7	-3.2	0.2	4.1	0.9	-2.0	-0.2	1.4	-0.3	0.2	0.1	0.4	0.3	4.0	1.0	3.1	2.8	2.0	2.5
Blood clot in the leg (DVT)	1.0	1.2	9.7	-0.4	2.3	-0.7	-0.7	0.6	1.4	0.2	-0.2	-0.4	3.1	-1.4	0.4	-0.5	-0.8	-0.3	0.5	-0.4	1.2	0.3
Medication: Paracetamol	0.3	0.5	1.5	-0.6	-0.1	-0.8	0.8	-1.1	0.1	0.1	-0.1	-1.1	1.2	-1.2	-0.3	-0.2	0.6	0.3	0.8	0.2	-0.3	-0.6
Headache pain in last month	0.3	0.6	3.8	0.4	0.3	-0.4	0.2	-1.1	0.2	0.1	1.1	-1.0	1.9	-1.2	-0.1	0.4	0.2	0.7	-0.1	0.4	0.8	0.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	6.0	1.2	-0.6	1.1	0.4	-2.5	-1.5	-0.2	1.0	1.2	0.6	-0.5	-0.6	0.5	0.5	0.8	0.5	2.0	0.2	1.0
Glaucoma (self-reported)	0.7	0.8	2.0	-1.3	-1.1	-0.3	0.5	0.3	-0.8	-1.3	-1.0	-0.8	-0.3	-1.4	-0.9	-1.4	0.4	0.4	0.4	-0.6	-1.2	-1.0
Gout (self-reported)	0.8	1.1	6.1	0.5	2.5	0.0	-1.0	1.3	-0.0	-1.2	-0.9	-0.2	0.9	0.2	1.4	1.0	-1.0	0.8	-0.7	-0.9	1.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.1	0.0	-0.4	-0.1	1.4	0.4	-1.7	-0.4	0.9	0.0	-0.3	0.1	-0.6	0.9	1.5	0.6	1.6	1.3	1.4	1.8
Medication: Amlodipine	0.5	0.7	1.8	-1.2	0.7	-1.1	-0.5	0.9	0.3	-0.1	-0.9	0.8	0.0	1.3	-1.0	0.8	-0.5	-0.9	-1.0	-1.1	0.6	-0.3
Medication: Ventolin 100micrograms inhaler	1.6	2.1	7.8	-2.2	0.4	-0.4	-1.5	1.2	0.8	-1.2	1.9	0.2	0.2	-1.4	-1.4	-2.2	-1.5	0.9	-1.7	-0.4	-2.8	-1.5
Birth weight	0.5	1.0	2.9	0.2	-0.5	-1.2	1.4	1.4	0.3	1.6	0.8	-0.7	0.0	-0.5	-0.7	-0.3	1.5	-1.7	1.4	0.0	1.3	0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.7	-0.4	-0.3	-1.3	0.3	-1.6	-0.4	0.6	0.9	-0.9	1.4	-1.4	-0.5	-0.7	0.4	-0.9	0.3	-0.8	-0.3	-1.5
High blood pressure (siblings)	0.5	0.7	2.3	-1.1	1.5	-1.4	-0.5	-0.7	0.8	1.0	1.2	0.2	0.2	0.6	-1.0	-0.2	-0.5	-1.5	-0.3	-0.1	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.2	3.4	0.7	-1.5	0.8	-0.5	1.8	-0.2	-0.4	-1.7	-1.8	-0.3	1.3	1.2	-0.8	-0.3	0.0	0.7	-0.9	-1.6	-0.9
Body fat percentage	0.2	0.9	6.7	-2.6	0.8	-0.5	-0.5	-0.9	-0.4	-0.9	-0.4	0.4	-0.2	-1.3	-1.6	0.2	-0.5	0.2	-0.7	-0.4	-0.3	-1.0
Leg fat percentage (right)	0.4	1.5	4.9	-2.2	2.0	-0.5	-1.7	-1.2	-0.1	-0.9	-0.5	2.0	0.1	-0.9	-1.0	0.6	-1.7	0.5	-1.8	-0.6	-0.3	-1.1
Arm fat-free mass (right)	0.3	1.4	4.4	-1.4	1.7	0.1	-1.6	-1.2	0.0	-0.7	-0.0	-1.2	2.1	-1.4	-0.4	-0.5	-1.6	0.7	-0.9	-2.0	-0.1	-1.1
Exposure to tobacco smoke outside home	1.2	1.6	5.2	-2.2	0.3	-0.5	-1.1	-0.5	-0.0	-2.3	0.5	0.3	0.8	-0.9	-1.9	-0.9	-1.2	1.4	-2.1	-0.5	-1.6	-1.2
Comparative body size at age 10	0.5	1.5	5.9	-0.5	-0.2	0.0	1.0	1.6	-2.4	-2.0	1.5	-0.5	-0.4	-1.6	-1.1	0.5	1.0	1.6	0.7	-0.1	1.5	1.5
Number of full brothers	0.6	0.7	2.5	-1.4	0.7	-1.1	-0.8	0.9	0.4	-0.6	1.3	-0.1	-0.6	-0.9	-1.6	-1.4	-0.8	0.1	-0.1	-0.2	-0.6	0.0
Worry too long after embarrassment	0.3	0.5	2.4	0.5	-1.6	0.8	1.2	0.2	-0.5	0.6	-0.6	0.1	-0.1	0.2	0.5	-0.3	1.1	-0.5	1.4	0.7	0.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	3.1	1.7	0.2	0.1	-0.0	-0.6	-0.4	0.5	-0.5	0.8	-0.6	1.2	1.8	0.8	0.2	-0.1	-0.1	-0.3	0.9	0.4
Wheeze or whistling in the chest in last year	1.5	2.7	11.2	-3.4	1.0	-1.6	-1.6	0.8	1.0	-0.6	-0.4	-1.9	-0.9	-1.3	-1.5	-1.8	-1.6	-0.8	-1.0	-2.8	-1.7	-2.3
Number of children fathered	0.4	0.5	2.2	0.4	-0.1	0.4	-0.7	-0.1	0.8	0.0	0.3	1.5	-0.8	0.6	0.2	1.1	-0.9	0.6	-1.2	0.6	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.6	-0.3	0.5	-1.1	-1.0	0.7	0.4	0.1	-0.2	0.3	0.8	0.0	0.8	-0.9	-1.0	-0.6	-0.4	-1.6	-1.2	-1.9
Age at first live birth	0.3	0.6	3.4	0.3	-0.9	1.5	0.3	1.8	-0.0	-0.4	-0.9	0.4	-0.4	0.7	0.6	0.1	0.3	-0.1	0.3	1.3	-0.2	0.4
Pulse wave peak to peak time	0.8	1.0	7.7	-1.3	-0.1	-0.4	-0.1	0.1	-0.7	-0.1	0.1	0.3	-2.8	-0.3	-1.7	-1.5	-0.1	-0.1	-0.4	-0.5	-1.0	-1.2
Health satisfaction	1.2	1.5	4.9	0.4	0.3	-1.6	2.0	-0.5	-1.0	0.8	2.1	-0.6	1.3	-0.3	-0.0	0.1	2.1	-0.4	1.5	0.4	2.2	1.2
Shortness of breath walking on level ground	1.5	1.8	5.3	-1.7	1.9	-1.5	-1.0	-2.3	2.2	2.1	0.9	0.1	0.7	-1.0	-1.0	-1.1	-0.8	-1.8	-0.1	-1.1	-0.2	-1.0
Qualifications: College or University degree	0.4	1.1	4.4	0.9	-1.4	0.4	0.4	1.0	-2.1	-1.3	-0.6	-0.6	-1.7	-0.2	0.6	-1.5	0.5	1.4	1.2	-0.2	-1.3	-0.4
Eye problems/disorders: None of the above	1.2	1.3	2.9	1.3	-0.5	0.9	0.5	1.2	-1.7	-1.6	1.0	0.4	-1.3	1.5	0.1	1.6	0.6	1.4	-0.3	1.2	1.6	1.3
Mouth/teeth dental problems: Loose teeth	0.9	1.1	4.1	-0.6	0.3	-2.0	0.5	1.5	0.0	-0.1	0.0	0.5	-0.6	-2.0	0.2	-1.7	0.6	-0.4	0.6	-1.1	-0.8	-1.7
Emphysema/chronic bronchitis	1.1	1.3	6.1	-2.5	1.6	-1.0	-1.2	-0.4	0.4	-1.0	0.8	1.0	-0.0	-1.6	-1.7	-1.1	-1.1	-0.0	-0.4	-1.1	-0.2	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	3.0	0.9	-0.5	0.7	0.2	1.7	-0.1	0.4	0.4	0.4	-1.7	0.6	0.4	0.2	0.3	-0.4	-0.0	1.0	0.1	0.4
Neck or shoulder pain in last month	0.9	1.3	6.1	0.3	0.5	-0.9	1.2	-1.2	0.4	1.2	2.5	-0.9	0.6	-0.8	-0.5	0.9	1.4	-0.5	0.8	1.2	1.8	1.5
Medication: Blood pressure	0.7	1.2	7.1	-1.1	1.6	-1.8	-0.4	2.7	1.4	0.2	-0.7	-0.5	-0.0	-0.0	0.3	-0.4	-0.5	-1.2	-0.5	-2.0	0.7	-0.6
Angina (self-reported)	0.7	1.0	2.5	-1.6	-0.2	-1.1	1.0	1.0	-0.3	-1.1	0.7	-1.5	0.8	-1.2	-1.1	-0.9	1.1	1.3	1.0	-0.5	0.7	0.1
Migraine (self-reported)	1.2	1.5	4.3	0.8	2.0	1.9	-1.9	-0.2	0.9	-0.4	-0.7	0.0	1.3	1.0	0.9	1.2	-1.9	1.1	-2.1	-0.1	0.6	0.8
Medication: Ibuprofen	1.7	2.0	14.4	0.5	-1.3	0.7	1.5	-3.8	-1.9	-0.6	0.4	-0.1	2.5	0.6	-0.7	0.9	1.5	1.1	0.8	1.4	0.8	1.0
Medication: Allopurinol	1.2	1.6	7.8	-0.1	2.8	-1.2	-1.6	1.7	1.3	0.5	0.1	1.0	0.5	-1.1	1.4	-0.4	-1.5	-1.1	-1.1	-1.8	0.6	-0.6
Medication: Omeprazole	1.6	1.9	5.3	-0.9	1.8	-1.5	-1.7	-0.5	2.3	1.9	-0.4	0.4	1.4	-0.9	-0.2	-1.2	-1.6	-2.0	-0.8	-2.1	-0.2	-1.0
Medication: Seretide 50 evohaler	1.0	1.2	5.2	-0.9	0.7	0.8	0.1	2.3	-1.1	-2.2	0.9	-0.6	0.1	0.6	-0.8	0.8	0.0	1.6	-0.4	0.8	0.8	1.5
Mean time to correctly identify matches	0.9	1.8	8.3	2.2	0.3	1.6	-0.3	0.1	-0.6	0.1	-1.0	2.9	-1.0	1.6	2.5	1.7	-0.2	0.5	-0.8	1.2	0.9	1.1
Heart disease (mother)	0.8	0.9	3.4	-1.4	-1.6	-0.8	1.3	-1.9	-0.7	0.0	0.4	-0.2	0.3	-0.2	-1.8	-0.2	1.3	-0.2	1.0	0.3	-0.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.5	0.1	1.6	-0.5	-0.1	-0.4	0.8	1.2	-0.6	0.7	1.2	0.7	0.5	0.9	-0.0	-1.4	0.2	-0.0	1.9	0.7
Whole body fat mass	0.3	1.2	7.6	-2.8	1.3	-0.6	-0.8	-1.4	-0.1	-0.9	-0.3	-0.1	0.8	-1.6	-1.5	-0.2	-0.8	0.2	-0.5	-1.0	-0.1	-1.2
Leg fat mass (right)	0.4	1.5	6.8	-2.6	1.9	-0.6	-1.4	-1.2	-0.1	-1.1	-0.1	0.6	1.0	-1.5	-1.3	-0.3	-1.4	0.5	-1.1	-1.1	-0.4	-1.4
Arm predicted mass (right)	0.3	1.5	4.7	-1.4	2.0	0.0	-1.8	-1.2	0.1	-0.7	-0.1	-1.3	1.9	-1.4	-0.4	-0.5	-1.8	0.6	-1.1	-2.2	-0.0	-1.0
Pulse rate, automated reading	1.0	3.2	13.5	-0.1	-2.9	1.5	2.3	-3.7	-2.5	-0.8	-0.8	0.3	0.3	1.6	-0.6	0.2	2.3	1.9	2.2	2.4	-0.4	0.6
Alcohol intake frequency.	0.9	2.1	4.7	-1.8	-0.4	-2.1	1.9	-1.8	-0.2	0.7	1.3	-2.0	1.0	-2.2	-2.1	-0.6	1.8	-1.4	1.4	-0.5	1.1	0.2
Comparative height size at age 10	0.4	2.2	6.9	-1.2	-0.0	0.3	-1.3	-2.3	-1.1	-2.6	-1.0	-1.2	0.7	-1.1	-0.7	-1.0	-1.1	2.3	-0.9	-1.9	-2.1	-1.9
Number of full sisters	1.0	1.2	4.0	-0.8	1.1	-0.4	-1.8	-0.4	-0.8	-1.2	-0.3	-0.3	0.5	-0.7	-0.2	-0.8	-1.7	0.4	-2.0	-1.6	-1.5	-1.4
Suffer from ‘nerves’	0.7	1.2	5.3	-0.9	1.4	0.3	-1.6	0.3	1.1	0.6	-0.5	-0.1	2.3	-1.1	-0.2	-0.7	-1.6	-0.8	-1.3	-1.3	-0.7	-0.5
Overall health rating	0.9	1.9	7.1	-1.6	1.1	-2.1	1.5	-0.9	-0.2	0.5	1.4	0.1	2.1	-0.9	-1.9	-0.2	1.5	-0.6	1.5	-0.2	2.7	1.1
Chest pain or discomfort	1.4	2.0	13.6	-1.5	0.6	-2.5	0.7	0.7	0.2	-0.2	3.7	-1.1	1.8	-2.1	-1.1	-1.8	0.7	0.7	0.2	-0.2	-0.1	-0.1
Had major operations	1.2	1.4	5.1	-1.4	-0.0	-1.2	-0.7	-1.2	0.5	0.0	-1.3	0.1	-0.6	-1.0	-0.7	-2.2	-0.6	-0.4	-0.0	-2.1	-1.2	-2.2
Age at last live birth	0.5	0.8	2.9	0.0	-1.0	1.7	0.5	0.2	0.1	0.0	-1.5	0.9	-1.5	1.2	-0.0	0.7	0.5	-0.6	0.6	1.3	0.5	0.8
Family relationship satisfaction	2.5	3.1	8.6	1.8	-1.1	1.4	2.5	0.3	-1.6	0.1	1.4	-0.6	0.6	1.2	0.7	1.8	2.7	0.8	2.3	2.9	2.5	2.8
Leg pain on walking	0.5	0.7	1.6	-1.1	1.1	-0.8	-0.5	-1.0	1.0	0.6	0.3	-0.5	1.0	1.2	-1.2	0.1	-0.3	-1.3	-0.7	-0.4	0.9	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.5	0.1	0.6	-0.2	-0.6	-1.1	0.1	0.6	-1.0	-1.2	1.6	0.2	0.8	-0.3	-0.4	-1.2	-0.3	-1.1	-0.7	-0.8
Commuting to job workplace: Car/motor vehicle	1.8	2.0	7.8	0.1	1.8	1.6	-2.4	-0.3	2.8	1.5	0.0	0.3	1.1	1.6	1.1	1.3	-2.5	-1.1	-1.6	0.1	-0.1	0.4
Illness, injury, bereavement, stress in last 2 years	2.6	3.1	10.4	-1.5	-3.1	-0.2	2.9	1.3	-1.9	-1.7	0.4	0.0	-1.2	-0.6	-2.3	-1.4	3.0	0.3	3.2	1.3	-0.2	0.3
Medication: Aspirin	0.3	0.4	1.3	-0.9	0.4	-0.9	-0.9	-0.3	0.8	-0.1	0.4	-0.2	-0.1	-0.8	0.2	-0.3	-0.9	-0.0	-0.8	-1.1	-0.6	-0.2
Supplements: Vitamin C	0.4	0.5	3.0	-0.4	-0.1	-0.4	-0.1	-0.2	0.0	0.1	-1.7	1.0	-1.1	0.5	-0.4	-0.4	0.0	-1.3	0.0	-0.7	-0.4	-0.8
Knee pain experienced in last month	0.8	1.2	5.2	0.3	-0.2	0.7	0.6	-2.3	-0.4	-0.6	0.7	-1.7	2.1	1.0	-0.3	0.7	0.4	1.1	0.1	1.4	0.8	1.8
Hypertension (Self-reported)	0.6	1.6	8.7	-1.9	1.6	-3.0	-0.9	0.5	0.9	-0.6	0.3	-0.1	-0.2	-0.6	-1.3	-1.0	-1.0	-0.8	-0.9	-2.7	0.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.0	-1.2	2.0	-1.2	-1.6	1.5	1.3	0.1	0.3	-0.1	1.9	-0.8	-0.5	-1.4	-1.6	-1.0	-0.3	-1.9	-0.3	-0.4
Illnesses of father: Heart disease	1.2	1.7	5.9	-1.8	1.1	-2.4	-0.2	-0.1	0.8	0.8	1.7	-0.8	-0.1	-2.1	-1.0	-2.0	-0.1	-0.9	-0.1	-2.0	-0.7	-1.3
Illnesses of siblings: Diabetes	1.3	1.6	7.6	-0.7	0.4	-1.1	-0.8	-0.7	-1.7	-1.8	0.7	-1.2	2.8	-1.7	-0.6	-0.7	-0.9	1.5	-1.0	-1.8	-0.4	-0.5
Smoking status: Previous	2.2	3.3	7.7	-1.9	1.8	-1.0	-2.8	0.5	2.3	0.7	-0.0	1.1	-1.4	-0.7	-0.6	-2.3	-2.8	-1.2	-2.3	-1.9	-2.6	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.9	-0.1	0.7	0.0	-1.2	1.3	0.4	-1.0	0.4	-1.7	0.2	-0.9	0.4	-1.6	-1.2	0.9	-0.7	-1.1	-1.1	-0.7
Whole body fat-free mass	0.3	1.5	5.9	-1.4	1.5	-0.1	-1.4	-1.4	0.3	-0.6	0.2	-1.5	2.4	-1.5	-0.4	-1.1	-1.4	0.4	-0.3	-1.9	-0.3	-1.1
Leg fat-free mass (right)	0.2	1.1	4.3	-1.5	1.0	-0.2	-0.6	-1.2	-0.0	-0.4	0.5	-1.8	2.1	-1.5	-1.0	-1.0	-0.5	0.0	0.4	-1.4	0.1	-0.7
Arm fat percentage (left)	0.2	1.0	7.0	-2.6	1.2	-0.7	-0.3	-1.2	-0.5	-0.8	0.3	-0.1	0.1	-1.5	-1.9	0.3	-0.3	-0.1	-0.3	-0.2	0.4	-0.6
Average weekly red wine intake	0.5	0.7	2.2	-0.4	-1.2	0.7	1.0	-1.1	-0.7	0.1	-0.5	-1.5	-0.9	1.1	-1.2	0.5	1.1	0.1	-0.2	0.6	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.0	0.2	0.1	-1.9	-0.9	-0.2	0.2	-0.4	0.6	0.9	0.0	-1.6	0.6	-1.4	-0.9	0.4	-1.1	-2.0	-1.6	-1.2
Mood swings	1.0	1.8	8.6	0.9	0.7	-0.5	1.7	-1.2	-0.7	1.2	1.2	-0.1	1.9	0.2	-0.0	0.4	1.7	-0.5	1.5	0.7	2.9	2.4
Loneliness, isolation	0.6	0.9	3.8	0.0	0.9	-0.8	0.2	0.9	-0.0	0.3	1.9	0.9	1.3	0.7	-1.1	0.3	0.3	-1.0	0.0	1.2	1.6	1.1
Long-standing illness, disability or infirmity	1.4	2.2	8.2	-2.5	0.2	-2.3	1.4	-1.1	0.2	-0.1	1.8	-1.1	2.1	-1.4	-2.9	-2.1	1.3	-0.3	1.1	-0.7	0.2	-0.1
Ever had bowel cancer screening	0.2	0.2	0.9	-0.8	-0.6	-0.2	0.2	-0.7	0.3	0.2	0.9	0.6	-0.6	-0.2	-0.5	-0.5	0.2	0.0	0.4	0.2	-0.6	-0.1
Diabetes diagnosed by doctor	1.0	1.7	8.8	-0.5	1.2	-1.8	-1.4	-1.7	0.2	0.3	-0.2	-0.6	1.2	-2.3	0.5	-0.4	-1.5	-0.1	-1.3	-3.0	-0.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	8.6	1.4	-2.9	1.6	1.0	-0.3	-1.4	-0.3	-1.2	-0.2	-0.3	1.5	1.6	1.2	1.0	0.5	0.2	1.3	-1.1	0.1
Friendships satisfaction	1.5	1.9	7.5	1.7	-0.7	0.8	1.4	-0.3	-1.1	0.9	2.7	0.6	-1.0	0.7	0.7	1.4	1.6	0.0	1.0	2.2	1.6	2.2
Qualifications: nursing, teaching	1.6	2.5	9.1	2.0	0.4	2.5	-0.7	-1.1	-0.9	-1.0	-0.5	0.8	-2.0	1.0	1.4	3.0	-0.8	2.0	-1.0	1.6	1.6	2.4
Commuting to job workplace: Walk	2.5	2.7	6.8	-0.2	-2.3	-2.6	2.5	0.5	-0.7	0.6	1.5	-0.7	-1.1	-2.6	-1.3	-2.0	2.5	-0.7	2.5	-0.2	-0.7	-0.9
Eye problems/disorders: Cataract	0.5	0.6	3.6	-0.1	-0.2	1.4	0.0	-1.7	0.2	-0.1	-1.0	-0.9	1.9	0.9	0.4	0.0	0.0	0.7	0.2	0.5	-0.0	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.1	1.7	-0.5	0.9	0.5	-0.2	-0.4	0.6	0.8	0.2	-2.2	2.0	0.9	1.5	0.4	0.3	-0.5	1.5	0.8	1.6
Medication for cholesterol	1.6	2.5	7.8	0.8	0.9	1.9	-2.2	0.7	2.2	1.1	-2.8	-0.6	-1.1	0.7	2.5	0.9	-2.1	-1.0	-1.8	-1.1	-1.1	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	9.2	-1.1	1.2	0.3	-0.9	-3.0	-0.4	-0.9	-1.3	-0.6	1.0	0.2	-0.2	0.0	-0.8	0.8	-0.2	-0.9	0.5	0.4
Back pain experienced in last month	0.4	0.6	2.2	-0.4	1.4	-0.8	-0.4	-0.7	1.2	0.7	0.3	-0.8	0.9	0.1	-0.3	-0.0	-0.4	-0.8	0.1	-0.9	1.5	0.9
Mineral and other dietary supplements	0.6	0.8	5.3	-0.7	-0.4	-0.1	0.9	2.3	-0.7	-0.6	1.9	-0.4	-0.6	-0.5	-0.7	-0.6	1.0	0.9	0.5	0.7	-0.1	0.1
Breast cancer (self-reported)	0.7	0.8	2.5	0.1	0.1	0.2	-1.5	-0.8	1.1	0.4	-0.9	0.2	0.5	0.0	0.6	0.3	-1.6	0.4	-1.6	-1.0	-1.4	-1.3
Asthma (self-reported)	0.5	1.0	5.1	-0.3	0.1	-0.2	-0.7	2.3	1.0	0.3	1.0	-0.1	-1.2	1.4	0.4	-1.2	-0.8	-0.3	-1.4	-0.7	-1.6	-1.3
Osteoporosis (self-reported)	1.9	2.4	9.2	1.2	-0.1	1.9	-0.2	-2.5	-1.4	-1.3	-1.8	-3.0	0.6	2.3	1.5	1.9	-0.2	1.9	0.7	0.3	0.8	1.1
Osteoarthritis (self-reported)	0.7	1.0	2.3	-1.1	1.0	-1.4	0.1	-0.4	0.7	1.1	1.2	-1.5	1.5	-0.4	-1.3	-0.4	-0.0	-1.4	0.1	-0.1	1.2	0.7
Medication: Aspirin	0.3	0.5	1.2	-0.8	0.2	-1.0	-0.8	-0.1	0.9	0.1	1.1	-0.5	-0.7	-1.1	0.2	-0.4	-0.7	-0.0	-0.7	-0.9	-0.6	-0.2
Medication: Gliclazide	1.0	1.2	6.4	-0.0	0.4	-0.6	0.6	-1.2	-1.3	-1.3	0.5	-1.2	2.5	-1.4	0.2	0.5	0.5	1.7	0.7	-0.6	1.3	0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	3.5	0.2	0.4	0.3	-1.2	-0.6	1.9	1.4	-0.8	1.3	1.6	0.6	0.2	-0.1	-1.3	-1.4	-0.7	-0.4	-0.4	-0.1
Smoking status: Current	0.2	0.3	1.3	0.1	0.2	-1.0	0.2	-0.9	-0.9	-0.2	-0.1	-0.1	-0.1	-0.9	0.6	-0.4	0.2	0.5	0.6	-1.1	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.1	1.6	0.8	0.7	-1.1	0.6	0.0	0.2	-1.7	1.5	-0.5	2.3	2.0	1.3	-1.0	-0.5	-0.4	-0.4	0.9	0.5
Whole body water mass	0.3	1.4	5.9	-1.4	1.5	-0.1	-1.3	-1.2	0.4	-0.6	0.2	-1.6	2.4	-1.5	-0.5	-1.0	-1.4	0.4	-0.3	-2.0	-0.2	-1.1
Leg predicted mass (right)	0.2	1.1	4.4	-1.5	1.0	-0.2	-0.5	-1.2	-0.0	-0.3	0.4	-1.9	2.1	-1.5	-1.0	-1.1	-0.5	-0.0	0.5	-1.5	0.1	-0.7
Arm fat mass (left)	0.3	1.4	8.1	-2.8	1.9	-0.7	-0.9	-1.1	-0.4	-1.2	0.2	-0.5	1.1	-1.9	-1.9	-0.1	-0.9	0.2	-0.6	-0.8	0.3	-0.9
Number of self-reported non-cancer illnesses	1.4	2.4	17.3	-4.2	0.7	-1.3	-0.1	0.7	-0.3	-2.2	0.4	-1.7	0.1	-0.5	-3.4	-1.2	-0.2	0.7	-1.0	-1.6	-0.4	-0.8
Average weekly champagne plus white wine intake	1.8	2.4	7.8	2.8	0.5	0.5	0.5	0.5	1.2	2.4	0.3	1.6	0.2	2.3	2.0	2.2	0.6	-1.3	0.8	1.1	2.4	1.9
Miserableness	1.0	1.7	5.6	0.8	-0.8	1.0	1.8	-2.0	-0.7	0.6	0.2	-0.7	1.0	1.5	-0.3	1.4	1.8	-0.7	1.4	1.4	1.9	2.4
Guilty feelings	0.6	0.9	5.4	1.1	0.5	0.4	-0.0	0.9	0.2	0.8	2.3	0.9	0.7	1.3	0.6	0.8	0.0	-0.5	-0.5	0.8	1.4	1.3
Wears glasses or contact lenses	0.9	1.0	3.9	-1.4	-1.4	-1.3	0.9	0.8	0.3	-0.4	0.3	-0.2	0.4	-0.7	-1.1	-2.0	0.9	-0.1	0.8	-0.6	-1.5	-1.2
Ever taken oral contraceptive pill	0.6	0.6	2.9	-0.0	0.2	-0.8	-0.7	-0.2	0.7	0.5	1.7	1.1	0.7	-0.0	0.0	-0.9	-0.5	-0.2	-0.6	-0.1	-1.7	-0.9
Hearing aid user	1.0	1.2	4.1	1.1	0.8	0.2	-1.2	1.0	1.1	-0.1	0.2	-1.9	-1.4	-0.6	2.0	-1.3	-1.2	0.4	-0.7	-0.9	-1.1	-1.0
Mother’s age at death	0.6	0.8	4.4	0.9	-0.7	0.9	-0.1	-0.3	0.2	1.4	-2.1	-0.0	-0.0	1.0	1.5	1.0	-0.1	-0.9	0.9	-0.2	0.1	0.3
Financial situation satisfaction	1.1	1.4	3.6	1.5	-1.0	-0.5	1.8	-0.5	-1.9	-0.1	1.3	-0.5	-0.4	0.0	1.1	0.6	1.9	0.4	1.6	1.6	1.2	1.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	5.3	1.0	0.1	0.6	0.5	0.6	-1.3	-1.7	0.5	1.4	1.1	0.5	1.5	-0.1	0.4	2.3	0.9	1.1	0.4	1.4
Commuting to job workplace: Public transport	1.1	1.3	6.9	0.6	-0.6	-1.5	1.3	-1.0	-2.6	-1.1	0.5	-1.0	1.6	-0.9	0.3	-0.7	1.4	1.0	1.4	-0.1	0.3	0.1
Eye problems/disorders: Glaucoma	0.8	0.9	3.2	-0.5	-0.5	-0.9	0.6	-0.5	0.6	0.6	-1.0	-1.1	0.2	-1.6	0.2	-1.8	0.5	-0.8	1.1	-1.2	-1.1	-1.4
Medication: Blood pressure	0.6	1.1	5.1	-1.9	-0.0	-2.2	-0.0	-0.5	-0.0	-0.6	0.8	0.3	0.7	-0.7	-2.3	-1.5	-0.2	-0.4	-0.2	-1.5	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.0	-0.5	1.1	-0.5	-0.8	-1.4	0.5	-0.3	-0.2	0.0	0.1	-0.4	-0.4	-0.5	-0.8	0.1	-0.5	-0.8	-0.5	-0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.5	8.6	0.5	0.6	0.3	-1.2	-2.8	0.7	1.0	-2.9	0.3	0.5	1.0	1.2	0.6	-1.2	-1.6	-0.1	-1.0	-0.0	-0.1
High cholesterol (Self-reported)	0.6	1.1	5.3	-1.6	1.3	-0.7	-0.8	-1.1	0.3	0.3	1.9	-2.3	0.2	0.1	-1.0	-0.4	-0.8	0.1	-1.5	-0.4	-0.3	0.1
Medication: Bendroflumethiazide	0.6	0.9	3.1	-1.5	-0.5	-1.3	-0.2	1.1	-0.2	-1.5	0.1	-1.2	-0.5	-0.0	-1.4	-0.8	-0.3	0.3	-0.3	-1.8	-0.9	-0.8
Medication: Paracetamol	0.8	1.2	3.2	-1.5	-0.1	-1.4	1.1	-1.6	-0.2	-0.1	0.1	-1.4	1.8	-1.8	-1.2	-1.1	0.9	0.1	1.5	0.1	-0.3	-0.9
Medication: Lisinopril	1.4	1.8	6.9	-2.0	2.6	-1.6	-1.8	0.6	2.1	0.3	1.4	1.3	0.1	-0.5	-1.1	-0.3	-1.8	-1.0	-1.4	-0.8	0.3	-0.3
Medication: Atorvastatin	0.3	0.4	1.0	-0.5	-0.7	-0.7	1.0	-0.1	-0.3	0.7	0.9	-0.2	-0.4	0.8	-0.7	0.2	1.0	-1.0	0.2	-0.2	0.4	0.2
Illnesses of father: High blood pressure	0.8	1.0	3.7	0.4	0.3	-1.8	0.3	1.6	-0.4	-0.4	0.9	-1.4	-1.7	-1.9	-0.1	-1.0	0.2	0.4	-0.2	-1.1	-0.0	-1.1
Alcohol drinker status: Never	0.3	0.4	1.4	-0.6	-0.9	-0.1	0.8	-0.2	-0.8	-0.3	0.1	0.3	0.5	-1.2	-0.6	-0.6	0.9	-0.3	1.0	0.5	-0.5	-0.4
Ever smoked	1.6	2.8	6.9	-2.2	0.8	-2.0	-1.3	-0.3	1.0	0.7	1.6	0.9	-1.3	-2.3	-1.6	-2.6	-1.4	-0.4	-1.1	-2.0	-2.5	-2.6
Basal metabolic rate	0.3	1.5	5.1	-1.8	1.6	-0.2	-1.4	-1.3	0.2	-0.7	0.2	-1.3	2.2	-1.7	-0.8	-1.1	-1.4	0.4	-0.5	-1.9	-0.3	-1.2
Leg fat percentage (left)	0.4	1.6	5.7	-2.4	2.2	-0.3	-1.9	-0.5	-0.1	-1.1	-0.5	1.8	-0.0	-0.9	-1.1	0.7	-1.9	0.6	-2.0	-0.6	-0.3	-0.9
Arm fat-free mass (left)	0.3	1.3	7.4	-1.5	1.9	0.3	-1.4	-0.8	0.3	-0.6	-0.0	-1.1	2.7	-0.9	-0.4	-0.5	-1.5	0.6	-0.6	-1.5	0.2	-0.7
Number of operations (self-reported)	0.5	0.7	4.6	-0.6	-1.1	-0.3	0.7	-2.1	-0.1	0.2	-1.1	-1.0	-0.7	0.6	-0.6	-0.7	0.7	-0.1	1.0	-0.7	-0.2	-0.5
Average weekly beer plus cider intake	0.7	1.0	3.5	-0.4	1.3	1.2	-1.9	-1.6	-0.2	-0.3	-0.8	0.5	-1.1	0.5	0.1	1.0	-1.7	0.2	-1.6	0.3	-0.1	0.4
Irritability	0.7	1.1	4.6	1.8	0.0	-0.2	1.1	0.1	-0.1	1.5	1.0	0.3	-0.1	0.5	1.1	1.0	1.1	-0.9	0.8	0.7	1.9	2.1
Risk taking	1.0	1.5	4.9	2.2	1.0	0.6	-1.1	-0.2	-0.3	0.3	-0.3	1.3	-0.0	2.1	2.2	1.9	-1.0	0.5	-1.3	0.2	1.3	1.1
Ever had prostate specific antigen (PSA) test	1.2	1.3	5.5	-0.4	-0.6	1.3	-1.9	0.8	1.3	-0.3	-0.8	0.4	-1.1	1.4	0.2	0.9	-2.0	0.2	-2.4	-0.9	-1.4	-0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.7	-0.9	0.2	0.8	-0.2	-0.5	-1.3	-0.6	0.6	-1.1	-1.3	1.1	-0.9	0.3	-0.1	0.8	-1.0	0.8	-0.1	0.4
Age started oral contraceptive pill	1.1	1.4	3.8	0.9	-0.9	1.4	1.2	-0.9	-0.9	-0.4	-1.5	-1.2	0.8	0.4	0.8	1.8	1.3	0.5	1.2	1.1	1.6	1.9
Diastolic blood pressure, automated reading	0.2	0.7	2.3	0.8	1.5	-0.6	-0.7	1.5	0.3	-0.2	-0.2	-0.5	0.8	-0.4	1.4	0.1	-0.8	1.0	-0.5	-1.3	0.3	-0.1
Ever depressed for a whole week	0.2	0.3	1.2	0.8	0.2	-0.2	-0.5	-0.7	0.3	0.7	0.3	0.6	-0.1	0.7	0.7	-0.2	-0.2	-0.4	-0.3	-1.1	0.1	0.2
Unable to work because of sickness or disability	1.6	2.1	7.5	-1.0	-1.5	-0.2	2.7	-1.4	-1.8	-0.9	0.1	0.3	0.8	-0.4	-1.1	0.6	2.6	1.0	2.7	1.3	1.4	1.5
Commuting to job workplace: Cycle	1.2	1.4	3.5	1.1	-1.5	1.9	0.8	-0.9	-0.6	-0.9	-0.8	-1.1	1.3	1.3	0.7	0.4	0.9	1.8	1.0	1.4	0.8	1.8
Myopia	0.2	0.3	1.7	-0.1	0.5	-0.2	-0.1	-0.3	-0.7	-1.2	0.2	1.0	0.9	-0.2	-0.5	-0.1	-0.2	1.3	-0.4	-0.1	-0.2	-0.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	12.5	2.7	-1.4	3.5	0.5	-1.6	-1.0	1.1	-1.1	0.2	-0.3	1.3	2.3	1.5	0.7	0.4	0.8	2.5	0.0	0.9
Cholesterol lowering medication	1.4	2.0	10.5	-1.7	1.9	-1.1	-0.4	-2.8	-0.6	0.1	3.2	-0.8	1.2	-0.4	-2.3	-0.2	-0.4	0.4	-1.4	0.4	0.8	1.0
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.6	-1.7	0.8	-1.7	-0.9	0.3	1.8	1.2	0.2	0.2	1.5	-1.0	-1.5	-1.9	-0.8	-1.8	-0.2	-1.6	-0.9	-1.3
Pain experienced in last month	0.5	0.8	2.3	-0.4	-0.8	0.4	0.6	1.5	-1.5	-1.5	-1.1	-0.3	-1.4	-0.3	0.1	-0.4	0.7	0.7	1.4	0.3	-0.8	-0.8
Supplements: Calcium	0.4	0.4	1.9	1.4	-0.7	0.2	-0.1	0.2	0.2	0.6	-0.5	0.5	-0.6	1.4	0.5	0.4	-0.1	-1.1	-0.1	0.1	-0.2	0.5
Basal cell carcinoma (self-reported)	0.6	0.7	4.3	-1.0	0.6	-1.0	0.1	-0.6	0.9	1.1	-0.0	0.3	2.1	-0.6	-1.1	-0.2	0.1	-1.7	-0.0	-0.7	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.9	-1.7	-0.8	-0.1	0.3	0.6	0.6	0.1	0.1	0.3	-0.2	0.8	-1.0	-0.5	0.2	-0.4	0.2	-0.4	-0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	10.0	-0.7	2.2	-0.8	-0.8	0.4	1.4	0.0	-0.1	-0.7	3.2	-1.6	0.1	-0.8	-1.1	-0.2	0.3	-0.7	0.8	0.1
Heart disease (siblings)	1.8	2.2	4.6	-1.6	1.1	-0.7	-1.6	-1.5	1.9	1.5	-0.0	2.0	-0.9	1.5	-1.1	-0.0	-1.6	-2.1	-2.1	-1.7	-1.2	-1.7
Alcohol drinker status: Previous	0.3	0.4	2.7	0.1	0.6	-0.3	0.1	-0.3	0.5	0.7	-0.1	-0.6	-1.6	0.2	-0.1	0.5	0.1	-0.5	-0.3	-0.3	1.3	0.9
Pack years of smoking	1.0	1.4	4.9	-2.2	0.3	-1.1	-0.8	-0.3	-1.2	-1.6	-0.0	0.4	0.2	-1.4	-1.6	-0.8	-0.8	0.7	-1.2	-1.7	-1.1	-1.9
Impedance of whole body	0.3	1.7	10.8	1.2	-2.9	0.1	1.1	1.4	-0.3	0.1	0.0	0.2	-3.3	0.7	0.3	-0.3	1.2	0.0	0.2	1.1	-2.0	-0.3
Leg fat mass (left)	0.4	1.6	7.7	-2.8	1.9	-0.6	-1.5	-0.8	-0.2	-1.4	-0.0	0.5	0.9	-1.6	-1.4	-0.3	-1.6	0.6	-1.3	-1.2	-0.5	-1.4
Arm predicted mass (left)	0.3	1.7	7.6	-1.4	2.3	0.1	-1.8	-0.9	0.4	-0.7	-0.4	-1.1	2.8	-1.1	-0.2	-0.6	-1.9	0.6	-1.0	-2.0	0.1	-1.0