Hub : Genes

SLC1A4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1440 0.0390 5.6e-05 0.051 0.038 0.064 0.063 0.062 7.9e-07 2.0e-05 3.1e-08 3.9e-08 4.9e-08
2 GTEx Artery Tibial 0.2061 0.0506 6.3e-06 0.025 NA 0.069 NA 0.080 4.1e-03 NA 4.3e-06 NA 8.1e-07
3 GTEx Brain Cerebellum 0.3540 0.0940 6.7e-04 0.150 NA 0.122 NA 0.198 3.5e-05 NA 1.8e-04 NA 1.7e-06
4 GTEx Cells Transformed fibroblasts 0.4400 0.0510 2.0e-13 0.414 NA 0.394 NA 0.402 2.6e-33 NA 2.4e-31 NA 4.6e-32
5 GTEx Colon Sigmoid 0.1930 0.0710 5.3e-03 0.147 NA 0.023 NA 0.078 7.0e-06 NA 5.3e-02 NA 1.0e-03
6 GTEx Esophagus Muscularis 0.2960 0.0740 1.1e-04 0.025 NA 0.065 NA 0.103 1.1e-02 NA 8.3e-05 NA 7.7e-07
7 GTEx Heart Left Ventricle 0.1824 0.0665 6.6e-03 0.160 NA 0.203 NA 0.179 7.4e-09 NA 4.6e-11 NA 7.8e-10
8 GTEx Muscle Skeletal 0.2049 0.0439 5.7e-07 0.118 NA 0.107 NA 0.101 1.2e-11 NA 1.3e-10 NA 4.3e-10
9 GTEx Prostate 0.5890 0.1100 1.7e-04 0.007 NA 0.060 NA 0.049 2.1e-01 NA 1.3e-02 NA 2.3e-02
10 GTEx Testis 0.1970 0.0790 6.6e-03 -0.002 NA 0.009 NA -0.006 4.3e-01 NA 1.3e-01 NA 8.2e-01
11 NTR Blood 0.0734 0.0182 1.3e-07 0.025 0.037 0.030 0.037 0.025 1.1e-08 6.4e-12 4.9e-10 4.0e-12 9.2e-09
12 ROSMAP Brain Pre-frontal Cortex 0.1340 0.0322 9.8e-08 0.096 0.063 0.085 0.080 0.098 2.2e-12 1.4e-08 4.9e-11 1.7e-10 1.4e-12
13 YFS Blood 0.0623 0.0159 2.5e-07 0.028 0.025 0.021 0.028 0.026 1.1e-09 1.1e-08 1.6e-07 9.4e-10 3.6e-09
14 TCGA Bladder Urothelial Carcinoma 0.1040 0.0370 1.8e-06 0.106 0.056 0.053 NA 0.098 2.8e-09 1.6e-05 2.6e-05 NA 1.1e-08
15 TCGA Breast Invasive Carcinoma 0.0483 0.0174 2.9e-06 0.032 0.022 0.025 NA 0.028 2.7e-07 2.1e-05 5.1e-06 NA 1.3e-06
16 TCGA Colon Adenocarcinoma 0.0870 0.0430 9.9e-03 -0.001 0.012 0.000 NA 0.009 3.5e-01 6.6e-02 3.4e-01 NA 9.7e-02
17 TCGA Head and Neck Squamous Cell Carcinoma 0.0786 0.0317 3.5e-05 0.005 0.051 0.039 NA 0.036 8.3e-02 2.0e-06 3.0e-05 NA 6.0e-05
18 TCGA Kidney Renal Clear Cell Carcinoma 0.0492 0.0241 4.5e-03 0.004 0.014 0.011 NA 0.003 9.9e-02 8.8e-03 1.7e-02 NA 1.4e-01
19 TCGA Thyroid Carcinoma 0.0740 0.0320 1.5e-03 0.005 0.036 0.017 NA 0.010 8.9e-02 1.8e-04 7.9e-03 NA 3.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 0.6 0.9 3.8 1.9 0.6 1.0 -0.8 1.2 0.3 -0.0 -0.1 -0.1 -0.7 0.9 1.9 0.6 -0.8 0.2 -0.5 1.3 0.4 1.3
Bipolar Disorder or Schizophrenia 0.4 1.0 3.8 0.7 1.8 1.1 -1.9 1.1 0.8 -0.3 -0.5 -0.3 -0.6 -0.2 1.2 -0.1 -1.9 0.4 -1.3 0.2 -0.0 0.5
Depressed Affect (Nagel 2018) 0.5 1.0 3.7 -0.1 0.7 -0.5 1.0 -1.5 -0.2 0.7 1.7 0.8 1.2 0.2 -0.9 0.5 1.1 -0.3 0.1 0.7 1.9 1.6
Depression (Nagel 2018) 0.4 0.6 4.3 -0.4 -0.6 0.0 -0.2 -2.1 0.9 1.1 -0.3 -0.1 0.9 0.2 -0.5 0.3 -0.2 -1.1 -1.4 -0.3 -0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.5 1.6 9.2 1.2 -3.0 -0.0 1.6 -1.6 -1.5 -0.3 -0.1 -1.8 -1.4 -0.2 0.5 0.7 1.3 1.0 1.2 0.2 -1.0 -0.5
Neuroticism (Nagel 2018) 0.2 0.5 1.7 0.0 -0.4 0.2 0.8 -0.9 0.0 1.1 1.1 1.3 0.7 -0.0 -0.5 0.1 0.7 -0.6 0.1 0.6 0.6 0.9
Schizophrenia (2018) 0.4 0.9 3.4 -0.7 1.8 0.5 -1.8 0.5 0.7 -0.3 -0.8 -0.3 -0.4 -1.1 -0.0 -0.6 -1.8 0.2 -1.2 -0.9 -0.4 -0.6
Schizophrenia vs Biploar Disorder 1.4 1.9 5.8 -1.9 2.0 -1.3 -0.9 2.4 1.4 0.7 1.5 1.7 0.6 -0.1 -2.0 -0.4 -0.9 -1.7 -1.2 -1.4 0.7 -0.2
Worry (Nagel 2018) 0.3 0.7 2.7 -0.8 0.2 -0.3 -0.4 1.0 0.6 0.3 1.0 1.7 0.9 -1.2 -0.8 -1.2 -0.6 -0.3 -0.8 -0.2 -0.9 -0.5
Alzheimer’s Disease (in mother) 2.0 2.4 7.2 -1.5 -0.7 -1.9 1.0 2.4 -1.2 -2.4 2.7 -0.1 -0.7 -2.2 -1.9 -1.8 1.0 1.3 1.1 0.1 -1.0 -0.4
Alzheimer’s Disease (in father) 1.8 1.9 7.7 1.4 -2.1 1.1 1.8 0.3 -2.8 -0.5 0.0 -0.8 -0.6 1.4 0.6 1.8 1.9 0.6 1.2 1.6 0.8 1.7
Alzheimer’s Disease (including proxy) 1.2 1.7 5.6 1.1 -1.8 -0.8 2.1 0.7 -2.4 -0.9 1.6 -0.4 -0.5 -0.6 0.5 0.5 2.3 0.7 2.0 0.9 0.5 1.2
Crohns Disease (2017) 0.4 0.9 3.3 -0.9 0.0 0.4 0.4 -0.9 1.5 1.6 -0.7 -0.9 1.7 -0.1 -1.1 0.5 0.5 -1.8 0.4 -0.5 0.6 -0.1
Irritable Bowel Disease (IBD) 0.6 1.4 4.6 -1.2 -0.5 -0.3 1.3 -0.1 1.4 1.5 0.1 -1.3 2.0 -0.2 -1.8 -0.1 1.3 -2.1 1.5 0.5 0.8 0.1
Ulcerative Colitis (UC) 0.7 1.3 4.3 -0.5 -0.9 -1.0 1.6 0.4 1.1 1.6 0.6 -0.8 0.7 -0.1 -1.2 -0.5 1.6 -2.1 2.0 0.9 0.7 0.1
Major Depression (MDD) 0.8 1.0 4.6 1.3 1.0 1.0 0.2 0.1 0.2 0.2 -0.4 0.1 1.5 0.6 1.4 0.7 0.1 1.0 0.2 0.5 1.9 2.1
Reaction Time 1.1 2.1 7.4 2.7 -0.0 1.4 0.4 0.7 -0.5 1.0 -0.4 2.1 -0.4 1.9 2.6 1.8 0.5 -0.3 -0.0 1.8 1.6 1.8
Verbal and Numeric Reasoning (VNR) 0.3 0.8 4.3 -0.8 -2.1 -0.5 1.0 -0.4 -0.5 -0.2 0.7 -0.6 -1.4 -0.8 -1.1 -0.7 0.9 0.2 0.7 -0.4 -1.2 -0.9
Breast Cancer 1.0 2.3 8.0 -1.2 1.4 -2.7 -0.5 2.8 1.0 0.3 1.1 0.5 -0.7 -2.8 -1.0 -1.4 -0.3 -1.2 -0.7 -2.1 -0.4 -2.1
Ovarian Cancer 0.3 0.4 1.2 1.0 0.5 -0.5 -0.6 -0.9 0.6 0.6 0.8 1.1 0.2 0.4 0.9 0.5 -0.8 -0.1 -0.7 0.2 0.5 0.7
Prostate Cancer 0.6 0.9 4.2 -1.1 -1.4 0.7 0.1 0.7 0.6 -0.2 0.0 -0.4 -1.4 2.0 -1.4 0.1 0.2 -0.6 -0.3 1.0 -1.6 -0.6
Age at First Birth 0.4 0.5 1.7 0.8 -0.7 0.7 -0.3 -0.5 0.1 1.2 -1.0 0.3 -1.3 -0.2 0.6 0.8 -0.3 -1.3 -0.4 -0.2 -0.9 -0.5
Bipolar Disorder (2011) 0.0 0.0 0.7 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.0 0.0 -0.2 -0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 -1.3 0.8 -0.2 -0.0 -1.0 -1.1 -0.1 -0.3 -0.9 0.2 -0.5 -0.8 -0.1 -0.0 -0.0 0.5 -0.4 0.6 -0.2
Coronary Artery Disease (CAD) 0.8 0.9 2.6 0.8 -1.1 0.5 1.2 -1.5 -1.6 -0.5 -1.1 -0.2 0.7 0.1 0.8 0.8 1.3 0.8 1.1 1.0 0.4 0.9
Crohns Disease (2012) 0.9 1.5 9.1 -0.2 0.2 -0.7 0.3 -0.7 2.0 2.9 1.1 -0.9 1.3 -0.5 -0.9 -0.2 0.5 -3.0 0.4 -0.3 0.1 -0.6
Mean Putamen Volume 0.7 0.8 2.7 1.4 -0.5 0.4 0.5 1.5 0.2 0.4 -0.9 1.1 -1.6 1.0 1.5 0.3 0.3 -0.4 0.8 0.6 0.0 0.5
Fasting Glucose 0.5 0.6 1.8 -1.4 0.9 -0.4 -0.2 0.8 -0.3 -0.8 0.4 -1.1 0.4 -0.9 -0.9 -0.6 -0.6 0.6 -0.4 -1.2 0.3 -0.4
HbA1C 1.0 1.1 4.7 1.1 0.9 0.5 0.3 0.6 0.5 1.2 -1.3 0.2 0.9 1.0 1.0 1.6 0.5 -1.0 1.2 0.1 2.2 1.0
HDL Cholesterol 0.8 1.3 6.8 1.5 -1.8 1.8 0.2 -2.6 0.0 1.0 -0.1 -0.1 0.1 1.2 1.4 1.1 0.2 -0.4 0.0 1.5 -1.0 0.3
LDL Cholesterol 0.8 1.2 3.6 1.1 1.1 1.2 -1.6 -1.9 0.8 1.3 -0.0 0.4 0.4 1.3 1.1 1.2 -1.6 -0.4 -1.8 0.3 0.2 0.1
Lupus 1.5 2.2 8.6 0.4 -0.5 -0.0 0.2 -2.9 2.8 2.7 -2.3 0.9 1.3 2.0 0.4 -0.2 0.4 -1.9 0.5 -0.9 -0.2 -0.8
Neuroticism (2016) 0.3 0.4 1.8 -0.5 0.2 1.4 -0.1 -0.8 -0.6 -0.6 0.3 0.7 0.6 0.6 -0.3 -0.1 0.3 0.4 0.1 1.1 -0.1 1.0
Primary Biliary Cirrhosis 1.1 1.5 4.9 1.3 -1.9 -0.1 1.3 -2.2 0.0 2.2 -0.8 -0.3 1.3 -0.4 0.8 -0.2 1.2 -1.8 1.9 -0.2 -0.2 -0.4
Rheumatoid Arthritis 0.7 1.0 7.1 -0.9 -0.6 0.6 0.2 -0.1 1.1 0.5 -0.5 2.7 -2.4 0.7 -0.8 0.2 0.2 -0.8 -0.6 0.3 -0.4 -0.3
Schizophrenia (2014) 0.2 0.5 2.0 -0.5 1.2 0.5 -1.4 1.1 0.3 -0.6 -0.2 0.5 -1.0 -0.5 -0.2 -0.2 -1.4 0.1 -0.9 -0.4 -0.1 -0.0
Triglycerides 0.6 1.1 3.1 -0.4 1.7 -1.6 -1.0 0.2 0.9 0.8 0.7 0.0 1.1 -1.0 -0.7 0.3 -1.1 -0.7 -1.8 -1.8 0.4 -0.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.9 -0.0 -0.1 -1.3 0.6 0.9 0.2 0.6 1.2 -0.4 0.8 -0.5 -0.2 0.3 0.6 -0.7 0.2 -1.0 1.7 0.4
Ulcerative Colitis 0.7 1.1 3.3 -0.8 -0.7 -0.9 1.5 -0.4 1.1 1.5 0.7 -0.7 0.9 -0.3 -1.1 -0.7 1.4 -1.8 1.7 0.7 0.5 0.1
Blood Eosinophil Count 0.4 3.2 12.0 -1.4 -1.6 -0.1 2.1 3.5 -1.9 -1.0 0.3 2.6 -3.0 2.5 -1.9 -1.0 1.9 0.3 1.5 1.6 -0.1 0.4
Blood Platelet Count 0.4 4.2 45.8 -0.6 -1.6 1.8 1.0 -6.8 -2.4 0.8 0.8 1.2 1.4 0.2 -1.5 2.3 0.9 1.2 -0.5 1.8 0.5 1.8
Blood Red Count 0.3 3.0 22.4 1.4 -2.7 0.9 1.4 -4.7 -0.4 0.9 -1.0 -1.2 1.1 3.3 1.2 1.0 1.4 0.5 1.3 1.0 0.0 0.5
Blood White Count 0.3 1.9 10.3 0.9 -0.4 -0.4 1.3 -3.2 0.2 1.5 -0.2 2.2 0.5 2.7 0.4 -0.1 1.2 -0.6 1.4 0.9 1.6 1.4
Heel T-Score 0.2 1.3 13.9 0.3 0.0 -0.0 0.0 3.7 -0.3 -1.6 -1.0 -0.3 1.2 -0.6 0.5 0.9 0.0 0.4 0.0 -0.5 1.7 1.1
BMI 0.2 1.4 6.8 -2.4 1.5 -0.8 -0.7 -1.6 -0.8 -0.7 -0.1 0.2 0.8 -2.6 -1.5 -0.9 -0.7 -0.2 0.3 -1.2 0.0 -1.1
Height 0.2 3.6 16.6 -0.4 -1.5 0.5 -1.8 -2.4 0.7 -1.2 -1.4 -2.5 -0.1 -1.1 0.6 -2.8 -1.9 1.4 -0.9 -2.5 -4.1 -2.8
Waist Hip Ratio (WHR) 0.4 1.6 3.8 -1.5 1.4 -1.5 -1.5 1.1 1.6 -0.3 0.6 0.2 0.2 0.1 -1.0 -1.9 -1.5 0.0 -1.6 -1.9 -1.5 -1.3
Systolic Blood Pressure 0.8 4.2 16.0 0.8 3.5 -3.5 0.2 2.7 0.2 0.7 1.9 -2.6 3.1 -0.4 0.7 0.4 0.2 -0.6 -0.6 -2.4 4.0 1.9
Smoking Status 1.3 3.0 7.4 -0.6 1.9 -1.7 -2.1 -1.3 1.8 1.7 0.2 1.4 -0.9 -1.7 0.9 -2.2 -2.0 -1.4 -1.2 -2.6 -2.3 -2.7
Allergy or Eczema 0.6 1.6 10.8 -1.3 -1.3 0.9 1.2 2.3 0.5 -0.3 0.2 -1.7 -3.3 1.2 -1.6 -0.4 1.1 -0.2 0.1 0.5 -0.3 -0.2
Cardiovascular Disease 0.5 1.5 5.3 -1.5 2.2 -2.3 -0.1 0.7 -0.4 -1.2 1.0 -1.4 1.3 -0.7 -1.1 -0.7 -0.2 -0.0 -0.1 -2.1 1.7 0.6
Hypothyroidism (self reported) 0.9 2.1 8.0 0.4 -0.5 -0.1 1.9 -0.3 -1.8 0.4 1.1 0.5 0.4 1.3 -0.3 1.1 2.0 0.1 2.5 1.8 2.6 2.8
Respiratory disease 0.7 1.5 3.4 -1.2 0.3 -0.7 -0.8 1.7 1.8 1.1 1.2 0.2 -1.1 0.9 0.1 -1.6 -0.8 -1.1 -1.3 -1.1 -1.8 -1.9
Type 2 Diabetes (T2D) (2018) 1.2 2.2 8.3 -0.2 1.7 -2.0 -1.2 -1.2 -0.3 -0.6 1.1 -0.8 2.7 -2.9 0.1 -0.5 -1.3 0.7 -1.5 -2.7 0.5 -0.8
Lung FEV1/FVC ratio 0.6 2.8 25.7 0.6 0.2 -1.3 1.5 -1.4 -1.1 0.8 0.5 5.1 -2.0 -0.8 -0.9 0.8 1.4 -0.8 1.4 0.6 2.5 1.4
Lung FVC 0.6 2.8 13.2 0.9 -1.2 2.4 0.5 2.4 -1.8 -1.4 -2.4 -0.5 0.5 3.6 1.1 1.6 0.6 1.1 1.2 1.6 1.4 1.8
Neuroticism 0.2 0.5 1.9 -0.3 0.5 -0.6 -0.2 -0.7 0.5 0.6 1.4 0.7 1.1 -0.7 -0.4 -1.1 -0.2 -0.4 -0.2 -0.3 -0.8 -0.2
Chronotype (morning person) 1.2 2.8 9.9 -1.0 0.9 -0.9 -2.5 2.3 2.8 0.0 1.2 0.4 1.0 -0.2 0.2 -1.1 -2.4 -0.4 -3.1 -1.3 -2.4 -2.1
Hair Pigment 0.2 5.8 14.9 -0.3 2.2 -2.1 -3.3 -1.9 3.1 1.9 1.8 1.9 0.5 -3.4 0.6 -1.8 -3.2 -0.5 -3.9 -3.1 -2.9 -2.9
Tanning 0.2 1.9 7.0 -0.3 0.0 -2.6 0.5 -0.7 0.7 1.7 2.6 0.6 1.6 -1.1 -0.8 -2.6 0.5 -1.6 1.0 -0.7 -0.9 -1.4
Hand grip strength (left) 0.9 2.3 6.1 -1.0 2.2 -0.0 -2.3 2.5 0.6 -1.7 -0.7 -1.3 2.3 -1.5 0.1 -0.7 -2.1 0.1 -1.4 -2.4 -0.6 -0.6
Number of treatments/medications taken 0.4 0.8 2.3 -1.1 -0.4 -1.4 1.5 -0.6 0.5 0.4 -0.3 -0.5 0.7 0.7 -0.3 -0.2 1.5 -0.9 1.3 -0.8 1.1 0.4
Average weekly spirits intake 0.6 0.8 4.0 1.3 0.8 1.5 -0.5 -1.3 -0.4 0.1 -0.8 -0.2 0.4 0.1 2.0 1.0 -0.5 0.8 -0.1 0.2 0.5 0.7
Sensitivity / hurt feelings 0.4 0.7 3.6 -0.7 -1.3 0.1 0.6 -0.1 0.7 1.2 -0.7 1.9 -0.7 0.3 -1.0 -0.4 0.6 -1.2 0.7 -0.5 -0.5 -0.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 3.1 -0.1 1.2 -1.0 -0.3 -1.2 -0.1 0.0 1.0 -0.1 1.8 -0.6 -0.5 0.3 -0.3 -0.1 -0.7 -0.1 1.1 0.8
Hearing difficulty/problems: Yes 1.0 1.5 5.0 -1.9 0.5 -1.9 -0.0 -1.7 -0.3 -0.4 2.2 0.6 0.1 -2.2 -1.7 -1.7 -0.1 0.7 -0.4 -0.7 -0.5 -0.4
Relative age of first facial hair 1.3 2.8 12.8 -2.3 -0.2 -0.6 -1.9 0.1 2.3 0.7 0.4 1.1 0.1 0.3 -1.9 -2.1 -2.0 -1.2 -2.0 -0.7 -3.6 -2.2
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 4.3 -1.2 0.4 -2.1 1.2 -1.4 -0.2 -0.3 2.0 -0.9 1.8 -1.0 -2.0 -1.1 1.1 0.7 1.4 -0.1 1.4 0.9
Ever used hormone-replacement therapy (HRT) 0.8 1.0 4.4 1.5 -0.7 -1.0 0.4 -1.2 0.9 2.1 0.8 2.1 -0.3 0.4 0.8 0.0 0.4 -1.4 0.2 0.2 -0.6 -0.3
Ever had hysterectomy (womb removed) 2.2 2.5 6.3 0.3 1.7 -1.0 -2.5 -1.0 2.3 1.9 -0.4 -0.6 -0.1 -0.2 1.4 -0.9 -2.4 -1.5 -1.8 -2.4 -1.3 -2.0
Systolic blood pressure, automated reading 0.9 2.6 12.8 0.2 3.6 -2.7 -0.9 0.6 1.2 1.4 1.9 -1.9 1.3 -1.2 0.7 0.5 -0.9 -0.6 -1.3 -2.0 2.6 1.0
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 4.1 -0.8 0.3 -1.0 -0.6 -0.6 1.4 1.1 -0.9 -0.4 1.0 -0.8 -0.4 -1.1 -0.8 -1.0 -0.5 -2.0 -0.8 -1.1
Angina 0.7 1.0 2.3 -1.4 -0.2 -1.0 1.0 0.9 -0.3 -1.1 1.0 -1.4 0.9 -1.1 -1.2 -0.8 1.1 1.5 0.9 -0.2 0.7 0.2
Medication for hormone replacement therapy 1.9 2.1 6.1 0.5 -2.3 -1.1 2.5 1.0 -1.9 -0.7 1.7 0.8 -0.8 -1.4 -0.7 -1.2 2.4 0.9 2.4 0.8 -0.8 -0.3
Vitamin and mineral supplements 0.3 0.4 1.8 -0.9 -0.1 0.1 0.5 0.1 -0.7 -0.8 0.4 -0.3 -0.6 -0.7 -0.9 -0.3 0.5 1.3 0.8 0.3 0.0 0.0
Supplements: Zinc 0.3 0.3 1.4 0.7 -0.1 0.7 -0.4 0.1 -0.3 0.0 -0.2 0.9 -1.0 0.7 1.2 0.3 -0.3 0.0 -0.4 0.3 -0.1 0.6
Medication: Co-codamol 1.2 1.4 6.1 -1.0 0.2 -2.5 0.2 -0.5 1.2 0.8 -0.0 0.4 1.6 -1.4 -0.9 -1.6 0.1 -1.7 -0.1 -1.9 -0.5 -1.8
Medication: Metformin 1.5 2.1 12.8 -1.3 0.8 -2.2 -0.2 -0.5 -1.0 -1.2 0.5 -0.7 2.3 -3.6 -0.6 -1.1 -0.4 1.1 -0.3 -2.1 -0.5 -1.8
Diabetes (father) 0.8 0.9 5.8 0.2 -0.2 -1.0 1.2 -2.4 -1.6 -0.4 1.6 -0.4 0.4 -1.0 -0.0 0.4 1.2 0.9 0.6 0.2 0.7 -0.0
Diabetes (mother) 0.7 0.8 5.3 -0.6 0.5 -1.4 0.8 0.1 -1.1 -0.3 1.2 -2.3 -0.5 -1.2 -1.2 0.1 0.8 -0.4 0.4 -0.5 0.6 -0.1
Severe depression (siblings) 0.7 0.8 4.2 1.9 0.9 -0.2 -1.1 0.1 0.1 0.6 0.2 1.6 -0.0 0.1 2.0 0.5 -1.0 0.1 -1.3 0.1 0.0 0.2
Pack years adult smoking proportion 0.8 1.2 4.2 -2.0 0.5 -1.3 -0.6 -0.2 -1.4 -1.4 0.4 0.6 0.4 -1.3 -1.8 -0.7 -0.6 0.6 -0.9 -1.4 -0.7 -1.6
Impedance of leg (right) 0.3 1.5 8.1 1.0 -2.3 0.1 0.5 1.2 -0.4 -0.5 -0.1 1.2 -2.8 0.5 0.7 -0.4 0.5 0.9 -0.5 0.8 -2.5 -1.0
Leg fat-free mass (left) 0.2 1.2 4.0 -1.5 0.9 -0.3 -0.6 -1.6 0.1 -0.2 0.4 -1.6 2.0 -1.7 -0.9 -1.1 -0.5 -0.1 0.4 -1.5 -0.1 -1.1
Trunk fat percentage 0.2 0.9 6.6 -2.6 0.4 -0.9 -0.1 -1.0 -0.2 -0.6 -0.1 -0.1 -0.4 -1.6 -1.9 -0.2 -0.1 -0.1 -0.2 -0.5 -0.5 -1.1
Hand grip strength (right) 0.7 1.8 5.8 -0.4 1.4 0.4 -2.3 2.1 0.6 -1.1 -1.0 -1.7 0.6 -1.1 0.6 -0.2 -2.1 -0.0 -1.5 -2.4 -1.1 -1.0
Townsend deprivation index at recruitment 0.7 1.0 4.3 0.7 1.0 0.2 0.6 -2.1 -0.8 -0.0 -1.4 1.1 0.4 1.0 1.0 0.8 0.7 0.1 1.4 0.5 1.7 1.2
Current tobacco smoking 0.2 0.4 1.5 -0.6 0.2 -1.2 0.3 -0.7 -0.9 -0.3 0.1 -0.4 0.2 -1.2 -0.1 -0.6 0.3 0.4 0.6 -1.1 -0.1 -0.6
Average weekly fortified wine intake 0.9 1.0 4.4 0.4 0.1 -0.6 -0.1 0.2 1.9 2.1 0.3 -1.2 1.2 -0.4 0.5 -1.7 0.1 -1.5 1.1 -0.7 0.6 0.0
Maternal smoking around birth 1.0 1.4 4.8 -0.8 0.6 -2.2 -0.6 -1.2 1.0 1.2 1.6 1.8 0.8 -0.5 -0.1 -1.4 -0.6 -1.3 -0.7 -0.8 -0.9 -1.8
Fed-up feelings 0.5 0.8 4.9 1.0 1.2 -0.6 0.4 -1.0 0.3 0.8 0.9 0.3 2.2 -0.1 0.6 0.3 0.4 -0.4 0.3 0.3 1.8 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 3.5 -1.4 0.1 -0.3 -0.4 -1.9 0.4 0.1 -0.1 -0.2 1.4 0.1 -1.4 0.5 -0.3 -0.9 -1.3 -1.0 0.1 0.1
Relative age voice broke 0.8 1.2 9.2 -0.9 -1.9 0.5 -0.4 -0.6 0.1 -0.6 -0.0 -0.7 -0.2 -1.1 -0.6 -1.2 -0.6 0.9 -0.7 -0.3 -3.0 -1.5
Taking other prescription medications 0.3 0.5 1.7 -1.0 0.3 -0.1 0.8 -1.3 -0.0 0.3 0.4 0.9 0.9 0.2 -0.4 0.5 0.8 0.0 0.7 0.1 1.1 1.2
Age when periods started (menarche) 0.2 0.6 1.7 1.0 -0.6 0.8 0.2 1.0 1.3 1.2 1.2 -0.4 -0.4 0.4 1.0 -0.1 0.2 -0.6 -0.2 1.0 -0.4 -0.0
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 6.3 2.5 -1.4 1.4 1.0 -1.9 -0.8 0.7 -0.8 -0.7 0.5 1.3 2.1 1.8 1.0 0.7 1.1 1.2 1.2 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 8.5 0.1 1.3 0.2 -1.8 2.9 1.1 -0.9 -1.0 0.9 -0.0 -1.0 0.6 -0.7 -1.8 -0.1 -1.4 -1.1 -0.3 -0.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.4 -0.3 -0.4 -0.5 0.3 -0.4 -0.1 0.1 1.1 0.4 -1.0 -1.0 -0.1 1.2 0.3 0.2 -0.2 0.3 -0.3 0.2
Qualifications: CSEs or equivalent 0.3 0.3 0.9 -0.8 0.7 0.5 0.1 0.8 0.1 -0.7 0.6 -1.0 0.3 -0.2 -0.8 -0.5 0.0 -0.3 1.0 0.9 0.0 -0.1
Serious illness, injury or assault to yourself 0.6 0.7 3.0 1.1 0.4 -0.6 -0.1 -0.4 0.7 1.4 -0.8 -1.4 1.7 -0.3 1.1 0.0 -0.1 -0.4 -0.0 -1.0 0.2 -0.6
High blood pressure 0.7 2.1 10.4 -2.2 1.6 -3.2 -0.8 1.2 0.7 -1.1 0.4 -0.2 -0.2 -1.0 -1.8 -1.3 -1.0 -0.6 -0.9 -2.8 0.1 -1.0
Hayfever, allergic rhinitis or eczema 0.4 0.9 4.8 -0.6 0.1 -0.3 0.4 2.0 1.4 1.1 0.4 -0.4 -2.2 0.6 -0.7 -0.6 0.4 -1.2 -0.1 -0.3 -0.1 -0.6
Multivitamins +/- minerals 0.3 0.4 1.6 0.5 0.3 0.1 -0.7 -0.3 0.7 0.8 -0.2 0.2 0.2 0.3 0.7 0.3 -0.7 -1.3 -1.2 -0.5 -0.1 -0.1
Stomach or abdominal pain in last month 0.8 1.0 3.9 -0.2 -0.5 -1.0 1.3 -0.8 -2.0 -1.4 1.6 -0.1 0.3 -1.1 -0.8 -0.7 1.5 1.2 0.6 0.2 -0.1 -0.2
Supplements: Glucosamine 0.6 0.8 6.7 -0.8 0.5 -0.2 -0.6 -2.6 0.7 0.6 -1.5 -0.8 -0.7 -0.6 -0.8 0.5 -0.7 -0.9 -0.6 -0.9 0.1 -0.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.6 0.1 -0.8 -1.2 1.0 0.9 -0.9 -0.1 0.5 -1.0 -0.7 -1.3 -0.3 -0.7 1.1 -0.3 1.2 -0.2 -0.2 -0.3
Medication: Atenolol 1.0 1.3 3.0 -1.7 1.1 -1.3 -1.2 -0.6 1.7 0.1 1.4 0.9 1.0 -0.9 -1.0 -1.4 -1.1 -0.4 -1.3 -1.0 -1.2 -0.8
Medication: Levothyroxine sodium 0.3 0.6 2.2 -0.0 -0.2 -0.3 1.0 0.5 -1.0 0.3 0.9 0.0 0.6 0.5 -0.6 0.6 1.1 -0.1 0.9 0.8 1.0 1.5
Sitting height 0.1 0.5 2.3 0.3 -1.5 1.1 0.3 -0.6 0.2 -0.6 -0.6 -1.2 -0.0 0.2 0.2 -1.0 0.3 0.8 0.6 -1.0 -0.8 -0.3
Chronic bronchitis/emphysema (father) 0.7 0.8 2.2 -0.2 1.5 1.3 -1.4 0.9 0.4 -0.9 -0.6 0.6 -0.0 1.4 0.3 0.7 -1.4 0.8 -1.0 0.5 -0.1 0.4
High blood pressure (mother) 0.3 0.4 2.1 -0.8 0.3 -0.4 0.0 -0.0 -0.6 -1.1 0.6 -0.9 0.8 -1.4 -0.8 -0.4 0.0 0.5 0.2 0.0 -0.1 0.2
Body mass index (BMI) 0.3 1.4 7.1 -2.7 2.3 -0.5 -0.8 -1.1 -0.3 -0.7 0.1 0.2 1.6 -1.3 -1.8 0.5 -0.9 0.0 -0.6 -0.5 1.2 -0.1
Impedance of leg (left) 0.3 1.7 9.4 0.6 -2.0 0.1 0.2 2.4 -0.5 -0.9 0.2 1.1 -3.1 0.5 0.3 -0.6 0.2 1.0 -0.9 0.7 -2.5 -0.8
Leg predicted mass (left) 0.2 1.2 4.2 -1.6 0.9 -0.4 -0.6 -1.6 0.2 -0.2 0.3 -1.5 2.0 -1.7 -1.0 -1.2 -0.6 -0.2 0.4 -1.6 -0.2 -1.2
Trunk fat mass 0.3 1.2 7.2 -2.7 1.0 -0.8 -0.8 -1.4 0.1 -0.7 -0.2 -0.4 0.4 -1.7 -1.7 -0.5 -0.8 0.1 -0.5 -1.2 -0.6 -1.5
Waist circumference 0.5 2.0 9.1 -3.0 2.5 -0.8 -1.5 -1.5 0.4 -0.7 0.6 -0.0 1.6 -1.5 -1.9 -0.8 -1.6 0.4 -1.2 -1.3 0.0 -1.1
Number of incorrect matches in round 0.4 0.6 2.4 0.3 1.1 -0.3 -1.6 -0.3 -0.2 -1.0 0.5 1.0 0.1 -0.2 0.8 0.8 -1.6 0.3 -1.3 -0.2 -0.2 0.5
Past tobacco smoking 1.4 2.6 6.8 1.8 -1.3 1.3 2.2 0.4 -1.4 -0.4 -0.5 -0.6 1.6 1.5 0.6 2.1 2.2 0.4 1.7 2.0 2.6 2.6
Alcohol usually taken with meals 0.7 1.1 5.3 1.2 1.0 -1.0 0.3 -1.2 1.0 2.3 1.4 -1.0 1.5 0.2 0.5 0.9 0.5 -1.0 -0.1 0.1 1.5 0.7
Nervous feelings 0.2 0.4 2.2 0.5 -0.4 0.2 -0.3 1.5 0.9 0.8 -0.0 0.0 0.3 -0.4 0.6 -1.1 -0.3 -0.5 -0.1 -0.5 -0.3 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 3.2 -0.5 -0.1 -1.2 0.2 -1.8 1.0 1.5 0.9 -0.0 0.9 0.1 -0.4 -0.6 0.3 -1.3 -0.2 -0.6 0.1 0.0
Hearing difficulty/problems with background noise 0.7 1.2 4.9 -1.2 -1.8 -1.1 1.3 0.2 0.0 1.1 1.1 1.1 -2.2 -0.8 -1.4 -0.6 1.2 -0.9 0.8 0.3 -0.4 -0.4
Hair/balding pattern: Pattern 2 1.5 2.0 7.9 1.7 1.4 1.4 -0.7 -1.0 0.3 0.8 0.5 -0.1 0.9 2.2 1.4 2.2 -0.5 0.1 -0.7 1.1 2.8 2.4
Had menopause 0.3 0.4 1.5 0.4 0.1 0.5 -0.2 -1.2 0.3 0.7 -1.2 0.3 -0.1 0.7 0.7 1.0 -0.2 -0.1 -0.6 -0.7 0.3 0.3
Had other major operations 0.9 1.1 3.0 -0.2 -1.7 -0.2 1.5 -1.3 -1.4 -1.0 0.5 -1.3 -0.3 0.0 -1.1 -0.5 1.6 0.8 1.6 0.6 0.1 1.3
Forced vital capacity (FVC) 0.2 0.9 3.6 0.3 -1.1 0.9 -0.8 1.1 -0.3 -0.5 -1.6 -1.4 -0.4 0.9 0.9 -0.9 -0.7 0.2 0.5 -0.9 -1.9 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 12.2 0.0 1.2 -0.5 -1.6 3.5 1.4 0.1 0.5 0.8 -0.3 -1.0 0.3 -1.6 -1.6 -0.8 -1.4 -1.0 -0.8 -0.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.1 0.3 1.4 -0.6 -0.8 -0.8 0.4 0.2 0.6 0.2 1.2 0.6 0.1 0.4 -0.5 -0.3 -0.5 -0.7 1.1 0.4
Qualifications: None of the above 0.9 2.0 9.6 -3.1 2.5 -1.3 -1.2 -0.6 1.1 -0.4 0.3 0.2 0.9 -1.1 -2.7 -0.6 -1.2 -0.6 -1.0 -1.6 0.6 -0.4
Financial difficulties in last 2 years 0.6 0.9 2.7 0.4 1.4 0.0 -1.1 -0.8 0.2 -0.8 1.5 -1.1 0.7 -0.9 1.1 0.7 -1.1 1.6 -1.3 0.2 -0.1 0.2
Mouth/teeth dental problems 1.3 2.1 8.0 -0.4 2.3 0.8 -2.8 0.9 1.6 0.2 -1.1 1.9 1.3 0.5 0.6 -0.4 -2.7 -1.0 -1.8 -0.9 -0.9 -0.9
Heart attack 0.3 0.3 1.8 -1.4 -1.0 0.1 0.6 0.6 0.4 0.1 0.1 -0.1 -0.2 0.8 -0.9 -0.3 0.5 -0.4 0.3 -0.2 -0.3 0.5
Allergy 0.5 1.3 6.4 1.0 -0.4 0.6 0.2 -2.5 -1.9 -0.9 -1.0 0.5 1.8 -0.5 0.6 1.2 0.3 1.3 0.6 0.3 1.1 1.3
Pain all over the body in last month 0.7 0.8 6.9 -1.2 -0.4 0.7 0.4 2.6 0.0 -0.9 -0.3 -0.8 -0.7 0.1 -1.3 0.1 0.5 0.5 0.6 0.6 0.1 0.8
Diabetes (self-reported) 0.7 1.1 4.5 0.1 0.9 -0.9 -1.0 -1.5 -0.3 -0.0 0.0 -0.8 1.4 -2.1 0.9 -0.0 -1.1 0.7 -1.1 -2.0 0.0 -0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 4.2 -2.1 -0.9 0.4 0.0 1.1 -0.2 -0.4 0.3 -1.0 -0.5 -0.0 -1.4 -0.1 0.1 0.1 -1.0 0.7 -1.2 -0.5
Medication: Ramipril 0.9 1.2 7.0 -0.3 -1.0 -1.4 1.8 -0.0 -0.7 -0.0 0.3 -2.6 0.9 -0.0 -0.2 -0.9 1.8 0.1 1.4 -0.7 0.7 0.6
Medication: Simvastatin 0.2 0.3 2.0 -0.7 0.2 -0.8 0.1 -0.1 -0.1 -0.5 1.4 -1.0 -0.5 -0.3 -0.2 -0.5 0.0 0.9 -0.5 -0.2 -0.4 0.1
Fluid intelligence score 0.2 0.4 1.6 0.5 -0.8 0.9 -0.1 -0.7 0.7 1.0 -0.1 -0.3 -0.8 1.3 0.1 1.0 -0.3 -0.2 -0.5 0.1 -0.1 0.1
Illnesses of siblings 1.1 1.6 4.4 1.8 -1.0 2.0 1.0 1.1 -1.1 -1.2 -1.4 -0.2 -0.4 -0.3 1.9 0.4 1.0 2.1 1.7 1.1 0.6 0.9
Neuroticism score 0.2 0.4 2.6 0.6 0.6 -0.1 -0.1 -0.3 0.4 0.9 0.8 0.6 1.6 0.2 0.2 0.2 -0.1 -0.8 -0.4 -0.0 0.6 0.8
Weight 0.3 1.7 6.8 -2.6 1.7 -0.4 -1.6 -1.5 0.3 -0.8 0.0 -0.8 1.4 -1.6 -1.5 -0.6 -1.6 0.2 -1.0 -1.7 -0.5 -1.4
Impedance of arm (right) 0.4 1.9 11.0 1.1 -3.3 0.0 1.6 1.0 0.2 0.4 0.1 -0.9 -2.8 0.6 0.2 -0.9 1.8 -0.6 1.2 1.2 -1.9 -0.4
Arm fat percentage (right) 0.2 0.9 6.8 -2.6 1.2 -0.8 -0.3 -0.8 -0.1 -0.7 0.3 0.1 0.6 -1.3 -1.8 0.1 -0.3 -0.2 -0.3 -0.1 0.3 -0.5
Trunk fat-free mass 0.3 1.8 6.1 -1.2 1.7 0.1 -2.0 -1.1 0.7 -0.8 0.0 -1.5 2.5 -1.3 -0.0 -1.1 -2.0 0.7 -0.9 -2.3 -0.7 -1.3
Hip circumference 0.2 1.0 5.7 -1.6 1.6 -0.0 -1.1 -2.4 0.2 0.3 -0.0 -0.1 1.4 -1.2 -0.9 0.3 -1.0 -0.2 -0.6 -0.5 0.7 -0.5
Time employed in main current job 3.1 3.6 13.0 -1.8 3.6 -0.9 -3.0 0.9 2.0 0.5 0.4 1.1 2.0 -1.2 -1.0 -1.7 -3.0 -1.0 -2.5 -2.3 -0.6 -1.9
Alcohol intake versus 10 years previously 0.6 0.9 3.3 -0.7 -0.6 -1.8 0.7 -1.6 -0.5 -0.5 0.1 -0.4 1.1 -1.3 -0.3 -1.4 0.7 0.0 0.7 -1.0 -1.0 -1.5
Father’s age at death 1.6 2.1 6.2 1.7 -2.4 1.2 2.1 -0.1 -1.6 -0.4 -0.1 -0.8 -0.9 0.4 0.6 1.8 2.1 0.8 1.5 2.5 1.2 1.5
Worrier / anxious feelings 0.3 0.5 3.2 0.2 0.4 0.3 -0.3 -1.0 0.1 0.2 -0.2 1.8 1.5 0.9 -0.1 -0.1 -0.4 -0.3 -0.6 -0.2 0.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 6.4 -1.4 -0.7 -1.6 1.6 0.2 -0.3 -0.5 1.5 -0.6 2.5 -0.9 -1.8 -0.6 1.8 -0.1 1.2 -0.1 0.7 0.6
Falls in the last year 1.3 1.8 9.1 -3.0 0.8 -1.1 -0.8 -0.6 0.3 -0.8 -0.4 -1.1 0.5 -1.5 -2.3 -1.8 -0.8 -0.0 -0.9 -1.3 -2.0 -1.5
Hair/balding pattern: Pattern 3 1.2 1.9 8.1 -1.2 -0.5 -1.4 0.6 0.3 -1.5 -2.2 -0.1 -0.7 -2.4 -2.8 -1.0 -1.3 0.4 1.5 0.6 -0.9 -1.2 -1.4
Number of live births 0.4 0.5 2.3 -0.1 -0.9 0.6 0.8 0.1 0.8 1.5 -0.4 -0.5 0.2 0.8 0.4 0.1 0.9 -1.3 0.6 0.4 0.3 0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.5 0.6 -1.0 0.7 0.0 0.8 -0.8 -0.3 -1.6 -0.1 -0.6 1.1 0.7 -0.1 0.2 -0.0 1.3 -0.4 -0.1 0.1
Pulse rate 0.9 1.5 7.5 0.4 -1.4 0.3 1.6 -2.7 -1.7 0.4 1.4 0.2 0.1 -0.3 0.1 -0.4 1.8 0.9 1.4 1.8 -0.5 0.5
Happiness 1.8 2.1 6.7 1.9 -0.3 -0.4 2.3 -0.6 -0.6 1.4 1.4 0.3 1.1 1.1 1.1 0.5 2.4 -0.7 1.8 1.7 2.6 2.1
Noisy workplace 1.7 2.1 8.8 0.4 -0.7 1.7 1.8 -1.7 -1.4 -2.0 -0.1 -0.4 0.4 -0.1 0.1 0.6 1.8 3.0 1.1 2.1 1.0 2.2
Qualifications: A levels/AS levels or equivalent 1.1 2.4 7.5 2.3 -2.7 0.2 2.7 0.7 -2.2 -0.4 1.6 -0.5 0.3 0.3 0.8 -0.5 2.7 1.2 1.9 1.8 0.4 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.3 1.3 1.1 -0.1 -0.7 -0.8 -0.0 0.3 -0.4 -0.1 1.5 0.5 0.9 0.6 -0.7 0.6 -1.3 -0.7 0.4 -0.4
Mouth/teeth dental problems: Dentures 1.0 1.7 6.1 -1.6 -0.3 -1.8 -0.6 -2.5 0.8 0.4 -0.4 -1.6 -0.9 -1.7 -1.4 -0.7 -0.5 -0.6 -0.3 -2.2 -1.3 -1.8
Asthma 0.5 1.0 4.4 -0.6 0.2 -0.3 -0.7 2.1 0.9 0.2 0.8 -0.1 -1.3 1.4 0.1 -1.1 -0.8 -0.4 -1.2 -0.7 -1.6 -1.4
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 8.9 0.8 -0.9 0.9 1.2 -3.0 -1.9 -0.9 0.4 -0.3 1.9 0.9 -0.3 1.2 1.2 1.4 0.5 1.4 1.0 1.3
Medication: Cholesterol lowering 0.6 1.0 4.5 -0.7 -0.5 -1.0 -0.0 0.3 0.8 0.4 -1.0 -1.7 -1.2 -0.3 0.9 -1.1 -0.2 -0.4 0.2 -2.1 -1.2 -1.4
Depression (self-reported) 0.5 0.6 3.5 -0.6 -0.6 0.1 0.9 -1.9 -1.6 -0.8 -0.3 -0.4 -0.6 -0.5 -0.7 0.8 0.9 0.5 0.0 0.5 0.0 -0.3
Medication: Lansoprazole 1.0 1.2 7.1 -0.1 -0.2 0.4 1.6 0.8 -0.7 -0.6 0.3 -2.7 1.2 -0.5 0.1 0.5 1.4 0.8 1.7 0.7 0.9 1.4
Prospective memory result 0.4 0.5 2.2 -1.0 0.4 0.2 0.6 -0.8 -0.3 0.3 -1.1 -0.4 -0.2 -0.2 -0.6 0.4 0.7 -0.8 1.5 0.7 1.2 0.5
Lung cancer (father) 1.3 1.5 7.0 -0.4 -0.0 -0.2 -1.0 -0.1 1.8 0.9 -1.4 2.6 1.1 1.2 0.3 -1.0 -1.0 -1.1 -1.0 -1.5 -1.5 -1.7
Illnesses of mother 1.2 1.5 3.7 1.2 1.1 1.5 -1.8 -0.2 1.3 0.5 -1.0 1.9 0.2 1.9 1.8 0.6 -1.8 0.3 -1.8 0.2 -0.0 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.5 0.9 -1.5 0.5 0.2 1.6 -0.7 -0.5 -1.6 -0.1 -0.6 0.9 1.0 -0.5 0.3 0.2 1.2 -0.7 -0.6 -0.3
Pulse wave Arterial Stiffness index 0.8 0.9 7.4 1.3 0.2 0.3 -0.1 -0.2 0.9 0.4 0.1 -0.6 2.7 0.2 1.8 1.2 -0.1 -0.1 0.3 0.3 0.7 1.0
Impedance of arm (left) 0.4 1.9 11.6 1.0 -3.2 -0.3 1.6 0.1 -0.4 0.4 0.3 -0.9 -3.4 0.0 -0.2 -0.7 1.7 -0.6 1.1 1.0 -1.8 -0.4
Arm fat mass (right) 0.3 1.4 7.7 -2.8 2.1 -0.8 -1.0 -1.1 0.0 -0.8 0.4 -0.2 1.5 -1.6 -1.8 -0.1 -1.0 -0.0 -0.8 -0.9 0.4 -0.8
Trunk predicted mass 0.3 1.9 6.2 -1.1 1.7 0.0 -2.0 -1.2 0.6 -0.7 0.1 -1.6 2.5 -1.4 0.0 -1.2 -2.0 0.7 -0.9 -2.2 -0.7 -1.3
Standing height 0.3 2.7 13.1 -0.2 -1.2 0.0 -1.7 -0.9 1.3 -0.2 -0.4 -2.3 -0.2 -0.9 0.3 -2.4 -1.6 0.2 -0.9 -2.9 -3.6 -2.9
Length of working week for main job 0.6 0.6 3.6 -0.1 0.1 0.8 0.2 -0.6 -0.4 -0.7 -0.0 -1.9 -1.6 0.5 -0.3 1.1 0.1 1.0 0.0 0.5 1.2 0.5
Exposure to tobacco smoke at home 1.4 1.6 7.0 0.1 0.4 0.4 1.1 -2.1 -1.8 -1.4 0.7 0.7 1.6 -0.5 -0.5 0.9 1.1 2.6 0.8 0.8 1.6 1.2
Breastfed as a baby 1.1 1.4 4.3 1.2 -2.1 1.1 1.7 -0.8 -0.3 0.6 -1.2 -0.4 0.1 1.5 0.1 1.5 1.7 -0.1 1.0 1.2 1.5 1.3
Tense / ‘highly strung’ 0.5 0.8 1.8 -0.4 1.2 -1.3 -0.9 0.7 0.9 1.1 1.1 1.1 1.3 -0.9 -0.3 -0.7 -0.8 -0.8 -0.9 -1.0 0.2 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.1 0.8 -0.7 0.6 1.2 -2.0 -1.8 -0.5 -0.8 -1.6 0.2 -0.3 0.4 0.5 1.3 1.4 1.2 -0.4 1.3 1.2
Hair/balding pattern: Pattern 4 1.3 3.1 8.3 -0.1 1.2 -1.9 -1.9 0.8 2.9 1.8 -0.1 1.1 0.1 -0.7 1.0 -2.6 -1.9 -2.0 -1.5 -2.6 -2.1 -2.6
Birth weight of first child 0.3 0.5 3.0 -0.1 -0.5 -0.2 0.7 -1.7 0.5 1.4 0.6 -1.2 0.0 -0.3 -0.3 -0.5 0.6 -0.6 0.5 0.2 0.1 0.0
Peak expiratory flow (PEF) 0.7 1.5 5.5 -0.0 -1.3 0.7 1.7 -0.5 -2.3 -1.5 -0.5 1.4 0.1 -0.2 -0.4 0.7 1.8 1.3 2.0 1.5 1.1 1.2
Pulse wave reflection index 1.2 1.4 5.5 1.4 0.1 1.3 -1.5 1.8 0.8 -0.7 -2.4 -0.6 0.5 1.1 2.3 1.3 -1.5 -0.1 -0.7 -0.6 -0.3 -0.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.7 1.1 0.4 -0.5 -0.7 -0.7 1.6 1.5 0.9 0.7 1.1 -0.3 1.6 -0.7 -0.7 -0.6 -0.6 -0.9 -0.8 -0.5
Loud music exposure frequency 0.7 0.8 2.8 0.8 -1.7 0.7 1.2 -0.8 -1.5 -0.5 -0.2 -0.0 -1.2 0.3 0.4 0.3 1.1 0.6 1.1 0.6 0.1 0.9
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 5.5 2.3 -1.4 0.3 1.1 0.0 -0.9 0.7 0.6 -0.7 0.9 0.5 1.2 -0.1 1.2 -0.3 0.7 1.2 0.6 0.6
Mouth/teeth dental problems: Bleeding gums 3.3 4.3 16.9 1.7 -3.2 0.2 4.1 0.9 -2.0 -0.2 1.4 -0.3 0.2 0.1 0.4 0.3 4.0 1.0 3.1 2.8 2.0 2.5
Blood clot in the leg (DVT) 1.0 1.2 9.7 -0.4 2.3 -0.7 -0.7 0.6 1.4 0.2 -0.2 -0.4 3.1 -1.4 0.4 -0.5 -0.8 -0.3 0.5 -0.4 1.2 0.3
Medication: Paracetamol 0.3 0.5 1.5 -0.6 -0.1 -0.8 0.8 -1.1 0.1 0.1 -0.1 -1.1 1.2 -1.2 -0.3 -0.2 0.6 0.3 0.8 0.2 -0.3 -0.6
Headache pain in last month 0.3 0.6 3.8 0.4 0.3 -0.4 0.2 -1.1 0.2 0.1 1.1 -1.0 1.9 -1.2 -0.1 0.4 0.2 0.7 -0.1 0.4 0.8 0.7
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 6.0 1.2 -0.6 1.1 0.4 -2.5 -1.5 -0.2 1.0 1.2 0.6 -0.5 -0.6 0.5 0.5 0.8 0.5 2.0 0.2 1.0
Glaucoma (self-reported) 0.7 0.8 2.0 -1.3 -1.1 -0.3 0.5 0.3 -0.8 -1.3 -1.0 -0.8 -0.3 -1.4 -0.9 -1.4 0.4 0.4 0.4 -0.6 -1.2 -1.0
Gout (self-reported) 0.8 1.1 6.1 0.5 2.5 0.0 -1.0 1.3 -0.0 -1.2 -0.9 -0.2 0.9 0.2 1.4 1.0 -1.0 0.8 -0.7 -0.9 1.5 0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.1 0.0 -0.4 -0.1 1.4 0.4 -1.7 -0.4 0.9 0.0 -0.3 0.1 -0.6 0.9 1.5 0.6 1.6 1.3 1.4 1.8
Medication: Amlodipine 0.5 0.7 1.8 -1.2 0.7 -1.1 -0.5 0.9 0.3 -0.1 -0.9 0.8 0.0 1.3 -1.0 0.8 -0.5 -0.9 -1.0 -1.1 0.6 -0.3
Medication: Ventolin 100micrograms inhaler 1.6 2.1 7.8 -2.2 0.4 -0.4 -1.5 1.2 0.8 -1.2 1.9 0.2 0.2 -1.4 -1.4 -2.2 -1.5 0.9 -1.7 -0.4 -2.8 -1.5
Birth weight 0.5 1.0 2.9 0.2 -0.5 -1.2 1.4 1.4 0.3 1.6 0.8 -0.7 0.0 -0.5 -0.7 -0.3 1.5 -1.7 1.4 0.0 1.3 0.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.7 -0.4 -0.3 -1.3 0.3 -1.6 -0.4 0.6 0.9 -0.9 1.4 -1.4 -0.5 -0.7 0.4 -0.9 0.3 -0.8 -0.3 -1.5
High blood pressure (siblings) 0.5 0.7 2.3 -1.1 1.5 -1.4 -0.5 -0.7 0.8 1.0 1.2 0.2 0.2 0.6 -1.0 -0.2 -0.5 -1.5 -0.3 -0.1 0.4 -0.1
Forced vital capacity (FVC), Best measure 0.3 1.2 3.4 0.7 -1.5 0.8 -0.5 1.8 -0.2 -0.4 -1.7 -1.8 -0.3 1.3 1.2 -0.8 -0.3 0.0 0.7 -0.9 -1.6 -0.9
Body fat percentage 0.2 0.9 6.7 -2.6 0.8 -0.5 -0.5 -0.9 -0.4 -0.9 -0.4 0.4 -0.2 -1.3 -1.6 0.2 -0.5 0.2 -0.7 -0.4 -0.3 -1.0
Leg fat percentage (right) 0.4 1.5 4.9 -2.2 2.0 -0.5 -1.7 -1.2 -0.1 -0.9 -0.5 2.0 0.1 -0.9 -1.0 0.6 -1.7 0.5 -1.8 -0.6 -0.3 -1.1
Arm fat-free mass (right) 0.3 1.4 4.4 -1.4 1.7 0.1 -1.6 -1.2 0.0 -0.7 -0.0 -1.2 2.1 -1.4 -0.4 -0.5 -1.6 0.7 -0.9 -2.0 -0.1 -1.1
Exposure to tobacco smoke outside home 1.2 1.6 5.2 -2.2 0.3 -0.5 -1.1 -0.5 -0.0 -2.3 0.5 0.3 0.8 -0.9 -1.9 -0.9 -1.2 1.4 -2.1 -0.5 -1.6 -1.2
Comparative body size at age 10 0.5 1.5 5.9 -0.5 -0.2 0.0 1.0 1.6 -2.4 -2.0 1.5 -0.5 -0.4 -1.6 -1.1 0.5 1.0 1.6 0.7 -0.1 1.5 1.5
Number of full brothers 0.6 0.7 2.5 -1.4 0.7 -1.1 -0.8 0.9 0.4 -0.6 1.3 -0.1 -0.6 -0.9 -1.6 -1.4 -0.8 0.1 -0.1 -0.2 -0.6 0.0
Worry too long after embarrassment 0.3 0.5 2.4 0.5 -1.6 0.8 1.2 0.2 -0.5 0.6 -0.6 0.1 -0.1 0.2 0.5 -0.3 1.1 -0.5 1.4 0.7 0.0 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 3.1 1.7 0.2 0.1 -0.0 -0.6 -0.4 0.5 -0.5 0.8 -0.6 1.2 1.8 0.8 0.2 -0.1 -0.1 -0.3 0.9 0.4
Wheeze or whistling in the chest in last year 1.5 2.7 11.2 -3.4 1.0 -1.6 -1.6 0.8 1.0 -0.6 -0.4 -1.9 -0.9 -1.3 -1.5 -1.8 -1.6 -0.8 -1.0 -2.8 -1.7 -2.3
Number of children fathered 0.4 0.5 2.2 0.4 -0.1 0.4 -0.7 -0.1 0.8 0.0 0.3 1.5 -0.8 0.6 0.2 1.1 -0.9 0.6 -1.2 0.6 -0.3 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.6 -0.3 0.5 -1.1 -1.0 0.7 0.4 0.1 -0.2 0.3 0.8 0.0 0.8 -0.9 -1.0 -0.6 -0.4 -1.6 -1.2 -1.9
Age at first live birth 0.3 0.6 3.4 0.3 -0.9 1.5 0.3 1.8 -0.0 -0.4 -0.9 0.4 -0.4 0.7 0.6 0.1 0.3 -0.1 0.3 1.3 -0.2 0.4
Pulse wave peak to peak time 0.8 1.0 7.7 -1.3 -0.1 -0.4 -0.1 0.1 -0.7 -0.1 0.1 0.3 -2.8 -0.3 -1.7 -1.5 -0.1 -0.1 -0.4 -0.5 -1.0 -1.2
Health satisfaction 1.2 1.5 4.9 0.4 0.3 -1.6 2.0 -0.5 -1.0 0.8 2.1 -0.6 1.3 -0.3 -0.0 0.1 2.1 -0.4 1.5 0.4 2.2 1.2
Shortness of breath walking on level ground 1.5 1.8 5.3 -1.7 1.9 -1.5 -1.0 -2.3 2.2 2.1 0.9 0.1 0.7 -1.0 -1.0 -1.1 -0.8 -1.8 -0.1 -1.1 -0.2 -1.0
Qualifications: College or University degree 0.4 1.1 4.4 0.9 -1.4 0.4 0.4 1.0 -2.1 -1.3 -0.6 -0.6 -1.7 -0.2 0.6 -1.5 0.5 1.4 1.2 -0.2 -1.3 -0.4
Eye problems/disorders: None of the above 1.2 1.3 2.9 1.3 -0.5 0.9 0.5 1.2 -1.7 -1.6 1.0 0.4 -1.3 1.5 0.1 1.6 0.6 1.4 -0.3 1.2 1.6 1.3
Mouth/teeth dental problems: Loose teeth 0.9 1.1 4.1 -0.6 0.3 -2.0 0.5 1.5 0.0 -0.1 0.0 0.5 -0.6 -2.0 0.2 -1.7 0.6 -0.4 0.6 -1.1 -0.8 -1.7
Emphysema/chronic bronchitis 1.1 1.3 6.1 -2.5 1.6 -1.0 -1.2 -0.4 0.4 -1.0 0.8 1.0 -0.0 -1.6 -1.7 -1.1 -1.1 -0.0 -0.4 -1.1 -0.2 -1.0
Medication for pain relief, constipation, heartburn 0.3 0.5 3.0 0.9 -0.5 0.7 0.2 1.7 -0.1 0.4 0.4 0.4 -1.7 0.6 0.4 0.2 0.3 -0.4 -0.0 1.0 0.1 0.4
Neck or shoulder pain in last month 0.9 1.3 6.1 0.3 0.5 -0.9 1.2 -1.2 0.4 1.2 2.5 -0.9 0.6 -0.8 -0.5 0.9 1.4 -0.5 0.8 1.2 1.8 1.5
Medication: Blood pressure 0.7 1.2 7.1 -1.1 1.6 -1.8 -0.4 2.7 1.4 0.2 -0.7 -0.5 -0.0 -0.0 0.3 -0.4 -0.5 -1.2 -0.5 -2.0 0.7 -0.6
Angina (self-reported) 0.7 1.0 2.5 -1.6 -0.2 -1.1 1.0 1.0 -0.3 -1.1 0.7 -1.5 0.8 -1.2 -1.1 -0.9 1.1 1.3 1.0 -0.5 0.7 0.1
Migraine (self-reported) 1.2 1.5 4.3 0.8 2.0 1.9 -1.9 -0.2 0.9 -0.4 -0.7 0.0 1.3 1.0 0.9 1.2 -1.9 1.1 -2.1 -0.1 0.6 0.8
Medication: Ibuprofen 1.7 2.0 14.4 0.5 -1.3 0.7 1.5 -3.8 -1.9 -0.6 0.4 -0.1 2.5 0.6 -0.7 0.9 1.5 1.1 0.8 1.4 0.8 1.0
Medication: Allopurinol 1.2 1.6 7.8 -0.1 2.8 -1.2 -1.6 1.7 1.3 0.5 0.1 1.0 0.5 -1.1 1.4 -0.4 -1.5 -1.1 -1.1 -1.8 0.6 -0.6
Medication: Omeprazole 1.6 1.9 5.3 -0.9 1.8 -1.5 -1.7 -0.5 2.3 1.9 -0.4 0.4 1.4 -0.9 -0.2 -1.2 -1.6 -2.0 -0.8 -2.1 -0.2 -1.0
Medication: Seretide 50 evohaler 1.0 1.2 5.2 -0.9 0.7 0.8 0.1 2.3 -1.1 -2.2 0.9 -0.6 0.1 0.6 -0.8 0.8 0.0 1.6 -0.4 0.8 0.8 1.5
Mean time to correctly identify matches 0.9 1.8 8.3 2.2 0.3 1.6 -0.3 0.1 -0.6 0.1 -1.0 2.9 -1.0 1.6 2.5 1.7 -0.2 0.5 -0.8 1.2 0.9 1.1
Heart disease (mother) 0.8 0.9 3.4 -1.4 -1.6 -0.8 1.3 -1.9 -0.7 0.0 0.4 -0.2 0.3 -0.2 -1.8 -0.2 1.3 -0.2 1.0 0.3 -0.4 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.5 0.1 1.6 -0.5 -0.1 -0.4 0.8 1.2 -0.6 0.7 1.2 0.7 0.5 0.9 -0.0 -1.4 0.2 -0.0 1.9 0.7
Whole body fat mass 0.3 1.2 7.6 -2.8 1.3 -0.6 -0.8 -1.4 -0.1 -0.9 -0.3 -0.1 0.8 -1.6 -1.5 -0.2 -0.8 0.2 -0.5 -1.0 -0.1 -1.2
Leg fat mass (right) 0.4 1.5 6.8 -2.6 1.9 -0.6 -1.4 -1.2 -0.1 -1.1 -0.1 0.6 1.0 -1.5 -1.3 -0.3 -1.4 0.5 -1.1 -1.1 -0.4 -1.4
Arm predicted mass (right) 0.3 1.5 4.7 -1.4 2.0 0.0 -1.8 -1.2 0.1 -0.7 -0.1 -1.3 1.9 -1.4 -0.4 -0.5 -1.8 0.6 -1.1 -2.2 -0.0 -1.0
Pulse rate, automated reading 1.0 3.2 13.5 -0.1 -2.9 1.5 2.3 -3.7 -2.5 -0.8 -0.8 0.3 0.3 1.6 -0.6 0.2 2.3 1.9 2.2 2.4 -0.4 0.6
Alcohol intake frequency. 0.9 2.1 4.7 -1.8 -0.4 -2.1 1.9 -1.8 -0.2 0.7 1.3 -2.0 1.0 -2.2 -2.1 -0.6 1.8 -1.4 1.4 -0.5 1.1 0.2
Comparative height size at age 10 0.4 2.2 6.9 -1.2 -0.0 0.3 -1.3 -2.3 -1.1 -2.6 -1.0 -1.2 0.7 -1.1 -0.7 -1.0 -1.1 2.3 -0.9 -1.9 -2.1 -1.9
Number of full sisters 1.0 1.2 4.0 -0.8 1.1 -0.4 -1.8 -0.4 -0.8 -1.2 -0.3 -0.3 0.5 -0.7 -0.2 -0.8 -1.7 0.4 -2.0 -1.6 -1.5 -1.4
Suffer from ‘nerves’ 0.7 1.2 5.3 -0.9 1.4 0.3 -1.6 0.3 1.1 0.6 -0.5 -0.1 2.3 -1.1 -0.2 -0.7 -1.6 -0.8 -1.3 -1.3 -0.7 -0.5
Overall health rating 0.9 1.9 7.1 -1.6 1.1 -2.1 1.5 -0.9 -0.2 0.5 1.4 0.1 2.1 -0.9 -1.9 -0.2 1.5 -0.6 1.5 -0.2 2.7 1.1
Chest pain or discomfort 1.4 2.0 13.6 -1.5 0.6 -2.5 0.7 0.7 0.2 -0.2 3.7 -1.1 1.8 -2.1 -1.1 -1.8 0.7 0.7 0.2 -0.2 -0.1 -0.1
Had major operations 1.2 1.4 5.1 -1.4 -0.0 -1.2 -0.7 -1.2 0.5 0.0 -1.3 0.1 -0.6 -1.0 -0.7 -2.2 -0.6 -0.4 -0.0 -2.1 -1.2 -2.2
Age at last live birth 0.5 0.8 2.9 0.0 -1.0 1.7 0.5 0.2 0.1 0.0 -1.5 0.9 -1.5 1.2 -0.0 0.7 0.5 -0.6 0.6 1.3 0.5 0.8
Family relationship satisfaction 2.5 3.1 8.6 1.8 -1.1 1.4 2.5 0.3 -1.6 0.1 1.4 -0.6 0.6 1.2 0.7 1.8 2.7 0.8 2.3 2.9 2.5 2.8
Leg pain on walking 0.5 0.7 1.6 -1.1 1.1 -0.8 -0.5 -1.0 1.0 0.6 0.3 -0.5 1.0 1.2 -1.2 0.1 -0.3 -1.3 -0.7 -0.4 0.9 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.5 0.1 0.6 -0.2 -0.6 -1.1 0.1 0.6 -1.0 -1.2 1.6 0.2 0.8 -0.3 -0.4 -1.2 -0.3 -1.1 -0.7 -0.8
Commuting to job workplace: Car/motor vehicle 1.8 2.0 7.8 0.1 1.8 1.6 -2.4 -0.3 2.8 1.5 0.0 0.3 1.1 1.6 1.1 1.3 -2.5 -1.1 -1.6 0.1 -0.1 0.4
Illness, injury, bereavement, stress in last 2 years 2.6 3.1 10.4 -1.5 -3.1 -0.2 2.9 1.3 -1.9 -1.7 0.4 0.0 -1.2 -0.6 -2.3 -1.4 3.0 0.3 3.2 1.3 -0.2 0.3
Medication: Aspirin 0.3 0.4 1.3 -0.9 0.4 -0.9 -0.9 -0.3 0.8 -0.1 0.4 -0.2 -0.1 -0.8 0.2 -0.3 -0.9 -0.0 -0.8 -1.1 -0.6 -0.2
Supplements: Vitamin C 0.4 0.5 3.0 -0.4 -0.1 -0.4 -0.1 -0.2 0.0 0.1 -1.7 1.0 -1.1 0.5 -0.4 -0.4 0.0 -1.3 0.0 -0.7 -0.4 -0.8
Knee pain experienced in last month 0.8 1.2 5.2 0.3 -0.2 0.7 0.6 -2.3 -0.4 -0.6 0.7 -1.7 2.1 1.0 -0.3 0.7 0.4 1.1 0.1 1.4 0.8 1.8
Hypertension (Self-reported) 0.6 1.6 8.7 -1.9 1.6 -3.0 -0.9 0.5 0.9 -0.6 0.3 -0.1 -0.2 -0.6 -1.3 -1.0 -1.0 -0.8 -0.9 -2.7 0.3 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.0 -1.2 2.0 -1.2 -1.6 1.5 1.3 0.1 0.3 -0.1 1.9 -0.8 -0.5 -1.4 -1.6 -1.0 -0.3 -1.9 -0.3 -0.4
Illnesses of father: Heart disease 1.2 1.7 5.9 -1.8 1.1 -2.4 -0.2 -0.1 0.8 0.8 1.7 -0.8 -0.1 -2.1 -1.0 -2.0 -0.1 -0.9 -0.1 -2.0 -0.7 -1.3
Illnesses of siblings: Diabetes 1.3 1.6 7.6 -0.7 0.4 -1.1 -0.8 -0.7 -1.7 -1.8 0.7 -1.2 2.8 -1.7 -0.6 -0.7 -0.9 1.5 -1.0 -1.8 -0.4 -0.5
Smoking status: Previous 2.2 3.3 7.7 -1.9 1.8 -1.0 -2.8 0.5 2.3 0.7 -0.0 1.1 -1.4 -0.7 -0.6 -2.3 -2.8 -1.2 -2.3 -1.9 -2.6 -2.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.9 -0.1 0.7 0.0 -1.2 1.3 0.4 -1.0 0.4 -1.7 0.2 -0.9 0.4 -1.6 -1.2 0.9 -0.7 -1.1 -1.1 -0.7
Whole body fat-free mass 0.3 1.5 5.9 -1.4 1.5 -0.1 -1.4 -1.4 0.3 -0.6 0.2 -1.5 2.4 -1.5 -0.4 -1.1 -1.4 0.4 -0.3 -1.9 -0.3 -1.1
Leg fat-free mass (right) 0.2 1.1 4.3 -1.5 1.0 -0.2 -0.6 -1.2 -0.0 -0.4 0.5 -1.8 2.1 -1.5 -1.0 -1.0 -0.5 0.0 0.4 -1.4 0.1 -0.7
Arm fat percentage (left) 0.2 1.0 7.0 -2.6 1.2 -0.7 -0.3 -1.2 -0.5 -0.8 0.3 -0.1 0.1 -1.5 -1.9 0.3 -0.3 -0.1 -0.3 -0.2 0.4 -0.6
Average weekly red wine intake 0.5 0.7 2.2 -0.4 -1.2 0.7 1.0 -1.1 -0.7 0.1 -0.5 -1.5 -0.9 1.1 -1.2 0.5 1.1 0.1 -0.2 0.6 0.2 0.3
Handedness (chirality/laterality): Left-handed 0.9 1.1 4.0 0.2 0.1 -1.9 -0.9 -0.2 0.2 -0.4 0.6 0.9 0.0 -1.6 0.6 -1.4 -0.9 0.4 -1.1 -2.0 -1.6 -1.2
Mood swings 1.0 1.8 8.6 0.9 0.7 -0.5 1.7 -1.2 -0.7 1.2 1.2 -0.1 1.9 0.2 -0.0 0.4 1.7 -0.5 1.5 0.7 2.9 2.4
Loneliness, isolation 0.6 0.9 3.8 0.0 0.9 -0.8 0.2 0.9 -0.0 0.3 1.9 0.9 1.3 0.7 -1.1 0.3 0.3 -1.0 0.0 1.2 1.6 1.1
Long-standing illness, disability or infirmity 1.4 2.2 8.2 -2.5 0.2 -2.3 1.4 -1.1 0.2 -0.1 1.8 -1.1 2.1 -1.4 -2.9 -2.1 1.3 -0.3 1.1 -0.7 0.2 -0.1
Ever had bowel cancer screening 0.2 0.2 0.9 -0.8 -0.6 -0.2 0.2 -0.7 0.3 0.2 0.9 0.6 -0.6 -0.2 -0.5 -0.5 0.2 0.0 0.4 0.2 -0.6 -0.1
Diabetes diagnosed by doctor 1.0 1.7 8.8 -0.5 1.2 -1.8 -1.4 -1.7 0.2 0.3 -0.2 -0.6 1.2 -2.3 0.5 -0.4 -1.5 -0.1 -1.3 -3.0 -0.2 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 8.6 1.4 -2.9 1.6 1.0 -0.3 -1.4 -0.3 -1.2 -0.2 -0.3 1.5 1.6 1.2 1.0 0.5 0.2 1.3 -1.1 0.1
Friendships satisfaction 1.5 1.9 7.5 1.7 -0.7 0.8 1.4 -0.3 -1.1 0.9 2.7 0.6 -1.0 0.7 0.7 1.4 1.6 0.0 1.0 2.2 1.6 2.2
Qualifications: nursing, teaching 1.6 2.5 9.1 2.0 0.4 2.5 -0.7 -1.1 -0.9 -1.0 -0.5 0.8 -2.0 1.0 1.4 3.0 -0.8 2.0 -1.0 1.6 1.6 2.4
Commuting to job workplace: Walk 2.5 2.7 6.8 -0.2 -2.3 -2.6 2.5 0.5 -0.7 0.6 1.5 -0.7 -1.1 -2.6 -1.3 -2.0 2.5 -0.7 2.5 -0.2 -0.7 -0.9
Eye problems/disorders: Cataract 0.5 0.6 3.6 -0.1 -0.2 1.4 0.0 -1.7 0.2 -0.1 -1.0 -0.9 1.9 0.9 0.4 0.0 0.0 0.7 0.2 0.5 -0.0 0.5
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.1 1.7 -0.5 0.9 0.5 -0.2 -0.4 0.6 0.8 0.2 -2.2 2.0 0.9 1.5 0.4 0.3 -0.5 1.5 0.8 1.6
Medication for cholesterol 1.6 2.5 7.8 0.8 0.9 1.9 -2.2 0.7 2.2 1.1 -2.8 -0.6 -1.1 0.7 2.5 0.9 -2.1 -1.0 -1.8 -1.1 -1.1 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 9.2 -1.1 1.2 0.3 -0.9 -3.0 -0.4 -0.9 -1.3 -0.6 1.0 0.2 -0.2 0.0 -0.8 0.8 -0.2 -0.9 0.5 0.4
Back pain experienced in last month 0.4 0.6 2.2 -0.4 1.4 -0.8 -0.4 -0.7 1.2 0.7 0.3 -0.8 0.9 0.1 -0.3 -0.0 -0.4 -0.8 0.1 -0.9 1.5 0.9
Mineral and other dietary supplements 0.6 0.8 5.3 -0.7 -0.4 -0.1 0.9 2.3 -0.7 -0.6 1.9 -0.4 -0.6 -0.5 -0.7 -0.6 1.0 0.9 0.5 0.7 -0.1 0.1
Breast cancer (self-reported) 0.7 0.8 2.5 0.1 0.1 0.2 -1.5 -0.8 1.1 0.4 -0.9 0.2 0.5 0.0 0.6 0.3 -1.6 0.4 -1.6 -1.0 -1.4 -1.3
Asthma (self-reported) 0.5 1.0 5.1 -0.3 0.1 -0.2 -0.7 2.3 1.0 0.3 1.0 -0.1 -1.2 1.4 0.4 -1.2 -0.8 -0.3 -1.4 -0.7 -1.6 -1.3
Osteoporosis (self-reported) 1.9 2.4 9.2 1.2 -0.1 1.9 -0.2 -2.5 -1.4 -1.3 -1.8 -3.0 0.6 2.3 1.5 1.9 -0.2 1.9 0.7 0.3 0.8 1.1
Osteoarthritis (self-reported) 0.7 1.0 2.3 -1.1 1.0 -1.4 0.1 -0.4 0.7 1.1 1.2 -1.5 1.5 -0.4 -1.3 -0.4 -0.0 -1.4 0.1 -0.1 1.2 0.7
Medication: Aspirin 0.3 0.5 1.2 -0.8 0.2 -1.0 -0.8 -0.1 0.9 0.1 1.1 -0.5 -0.7 -1.1 0.2 -0.4 -0.7 -0.0 -0.7 -0.9 -0.6 -0.2
Medication: Gliclazide 1.0 1.2 6.4 -0.0 0.4 -0.6 0.6 -1.2 -1.3 -1.3 0.5 -1.2 2.5 -1.4 0.2 0.5 0.5 1.7 0.7 -0.6 1.3 0.6
Illnesses of father: None of the above (group 1) 0.7 0.9 3.5 0.2 0.4 0.3 -1.2 -0.6 1.9 1.4 -0.8 1.3 1.6 0.6 0.2 -0.1 -1.3 -1.4 -0.7 -0.4 -0.4 -0.1
Smoking status: Current 0.2 0.3 1.3 0.1 0.2 -1.0 0.2 -0.9 -0.9 -0.2 -0.1 -0.1 -0.1 -0.9 0.6 -0.4 0.2 0.5 0.6 -1.1 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 5.1 1.6 0.8 0.7 -1.1 0.6 0.0 0.2 -1.7 1.5 -0.5 2.3 2.0 1.3 -1.0 -0.5 -0.4 -0.4 0.9 0.5
Whole body water mass 0.3 1.4 5.9 -1.4 1.5 -0.1 -1.3 -1.2 0.4 -0.6 0.2 -1.6 2.4 -1.5 -0.5 -1.0 -1.4 0.4 -0.3 -2.0 -0.2 -1.1
Leg predicted mass (right) 0.2 1.1 4.4 -1.5 1.0 -0.2 -0.5 -1.2 -0.0 -0.3 0.4 -1.9 2.1 -1.5 -1.0 -1.1 -0.5 -0.0 0.5 -1.5 0.1 -0.7
Arm fat mass (left) 0.3 1.4 8.1 -2.8 1.9 -0.7 -0.9 -1.1 -0.4 -1.2 0.2 -0.5 1.1 -1.9 -1.9 -0.1 -0.9 0.2 -0.6 -0.8 0.3 -0.9
Number of self-reported non-cancer illnesses 1.4 2.4 17.3 -4.2 0.7 -1.3 -0.1 0.7 -0.3 -2.2 0.4 -1.7 0.1 -0.5 -3.4 -1.2 -0.2 0.7 -1.0 -1.6 -0.4 -0.8
Average weekly champagne plus white wine intake 1.8 2.4 7.8 2.8 0.5 0.5 0.5 0.5 1.2 2.4 0.3 1.6 0.2 2.3 2.0 2.2 0.6 -1.3 0.8 1.1 2.4 1.9
Miserableness 1.0 1.7 5.6 0.8 -0.8 1.0 1.8 -2.0 -0.7 0.6 0.2 -0.7 1.0 1.5 -0.3 1.4 1.8 -0.7 1.4 1.4 1.9 2.4
Guilty feelings 0.6 0.9 5.4 1.1 0.5 0.4 -0.0 0.9 0.2 0.8 2.3 0.9 0.7 1.3 0.6 0.8 0.0 -0.5 -0.5 0.8 1.4 1.3
Wears glasses or contact lenses 0.9 1.0 3.9 -1.4 -1.4 -1.3 0.9 0.8 0.3 -0.4 0.3 -0.2 0.4 -0.7 -1.1 -2.0 0.9 -0.1 0.8 -0.6 -1.5 -1.2
Ever taken oral contraceptive pill 0.6 0.6 2.9 -0.0 0.2 -0.8 -0.7 -0.2 0.7 0.5 1.7 1.1 0.7 -0.0 0.0 -0.9 -0.5 -0.2 -0.6 -0.1 -1.7 -0.9
Hearing aid user 1.0 1.2 4.1 1.1 0.8 0.2 -1.2 1.0 1.1 -0.1 0.2 -1.9 -1.4 -0.6 2.0 -1.3 -1.2 0.4 -0.7 -0.9 -1.1 -1.0
Mother’s age at death 0.6 0.8 4.4 0.9 -0.7 0.9 -0.1 -0.3 0.2 1.4 -2.1 -0.0 -0.0 1.0 1.5 1.0 -0.1 -0.9 0.9 -0.2 0.1 0.3
Financial situation satisfaction 1.1 1.4 3.6 1.5 -1.0 -0.5 1.8 -0.5 -1.9 -0.1 1.3 -0.5 -0.4 0.0 1.1 0.6 1.9 0.4 1.6 1.6 1.2 1.0
Tinnitus: Yes, now most or all of the time 1.0 1.2 5.3 1.0 0.1 0.6 0.5 0.6 -1.3 -1.7 0.5 1.4 1.1 0.5 1.5 -0.1 0.4 2.3 0.9 1.1 0.4 1.4
Commuting to job workplace: Public transport 1.1 1.3 6.9 0.6 -0.6 -1.5 1.3 -1.0 -2.6 -1.1 0.5 -1.0 1.6 -0.9 0.3 -0.7 1.4 1.0 1.4 -0.1 0.3 0.1
Eye problems/disorders: Glaucoma 0.8 0.9 3.2 -0.5 -0.5 -0.9 0.6 -0.5 0.6 0.6 -1.0 -1.1 0.2 -1.6 0.2 -1.8 0.5 -0.8 1.1 -1.2 -1.1 -1.4
Medication: Blood pressure 0.6 1.1 5.1 -1.9 -0.0 -2.2 -0.0 -0.5 -0.0 -0.6 0.8 0.3 0.7 -0.7 -2.3 -1.5 -0.2 -0.4 -0.2 -1.5 -0.4 -0.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 2.0 -0.5 1.1 -0.5 -0.8 -1.4 0.5 -0.3 -0.2 0.0 0.1 -0.4 -0.4 -0.5 -0.8 0.1 -0.5 -0.8 -0.5 -0.6
Supplements: Fish oil (including cod liver oil) 1.1 1.5 8.6 0.5 0.6 0.3 -1.2 -2.8 0.7 1.0 -2.9 0.3 0.5 1.0 1.2 0.6 -1.2 -1.6 -0.1 -1.0 -0.0 -0.1
High cholesterol (Self-reported) 0.6 1.1 5.3 -1.6 1.3 -0.7 -0.8 -1.1 0.3 0.3 1.9 -2.3 0.2 0.1 -1.0 -0.4 -0.8 0.1 -1.5 -0.4 -0.3 0.1
Medication: Bendroflumethiazide 0.6 0.9 3.1 -1.5 -0.5 -1.3 -0.2 1.1 -0.2 -1.5 0.1 -1.2 -0.5 -0.0 -1.4 -0.8 -0.3 0.3 -0.3 -1.8 -0.9 -0.8
Medication: Paracetamol 0.8 1.2 3.2 -1.5 -0.1 -1.4 1.1 -1.6 -0.2 -0.1 0.1 -1.4 1.8 -1.8 -1.2 -1.1 0.9 0.1 1.5 0.1 -0.3 -0.9
Medication: Lisinopril 1.4 1.8 6.9 -2.0 2.6 -1.6 -1.8 0.6 2.1 0.3 1.4 1.3 0.1 -0.5 -1.1 -0.3 -1.8 -1.0 -1.4 -0.8 0.3 -0.3
Medication: Atorvastatin 0.3 0.4 1.0 -0.5 -0.7 -0.7 1.0 -0.1 -0.3 0.7 0.9 -0.2 -0.4 0.8 -0.7 0.2 1.0 -1.0 0.2 -0.2 0.4 0.2
Illnesses of father: High blood pressure 0.8 1.0 3.7 0.4 0.3 -1.8 0.3 1.6 -0.4 -0.4 0.9 -1.4 -1.7 -1.9 -0.1 -1.0 0.2 0.4 -0.2 -1.1 -0.0 -1.1
Alcohol drinker status: Never 0.3 0.4 1.4 -0.6 -0.9 -0.1 0.8 -0.2 -0.8 -0.3 0.1 0.3 0.5 -1.2 -0.6 -0.6 0.9 -0.3 1.0 0.5 -0.5 -0.4
Ever smoked 1.6 2.8 6.9 -2.2 0.8 -2.0 -1.3 -0.3 1.0 0.7 1.6 0.9 -1.3 -2.3 -1.6 -2.6 -1.4 -0.4 -1.1 -2.0 -2.5 -2.6
Basal metabolic rate 0.3 1.5 5.1 -1.8 1.6 -0.2 -1.4 -1.3 0.2 -0.7 0.2 -1.3 2.2 -1.7 -0.8 -1.1 -1.4 0.4 -0.5 -1.9 -0.3 -1.2
Leg fat percentage (left) 0.4 1.6 5.7 -2.4 2.2 -0.3 -1.9 -0.5 -0.1 -1.1 -0.5 1.8 -0.0 -0.9 -1.1 0.7 -1.9 0.6 -2.0 -0.6 -0.3 -0.9
Arm fat-free mass (left) 0.3 1.3 7.4 -1.5 1.9 0.3 -1.4 -0.8 0.3 -0.6 -0.0 -1.1 2.7 -0.9 -0.4 -0.5 -1.5 0.6 -0.6 -1.5 0.2 -0.7
Number of operations (self-reported) 0.5 0.7 4.6 -0.6 -1.1 -0.3 0.7 -2.1 -0.1 0.2 -1.1 -1.0 -0.7 0.6 -0.6 -0.7 0.7 -0.1 1.0 -0.7 -0.2 -0.5
Average weekly beer plus cider intake 0.7 1.0 3.5 -0.4 1.3 1.2 -1.9 -1.6 -0.2 -0.3 -0.8 0.5 -1.1 0.5 0.1 1.0 -1.7 0.2 -1.6 0.3 -0.1 0.4
Irritability 0.7 1.1 4.6 1.8 0.0 -0.2 1.1 0.1 -0.1 1.5 1.0 0.3 -0.1 0.5 1.1 1.0 1.1 -0.9 0.8 0.7 1.9 2.1
Risk taking 1.0 1.5 4.9 2.2 1.0 0.6 -1.1 -0.2 -0.3 0.3 -0.3 1.3 -0.0 2.1 2.2 1.9 -1.0 0.5 -1.3 0.2 1.3 1.1
Ever had prostate specific antigen (PSA) test 1.2 1.3 5.5 -0.4 -0.6 1.3 -1.9 0.8 1.3 -0.3 -0.8 0.4 -1.1 1.4 0.2 0.9 -2.0 0.2 -2.4 -0.9 -1.4 -0.7
Fractured/broken bones in last 5 years 0.5 0.6 1.7 -0.9 0.2 0.8 -0.2 -0.5 -1.3 -0.6 0.6 -1.1 -1.3 1.1 -0.9 0.3 -0.1 0.8 -1.0 0.8 -0.1 0.4
Age started oral contraceptive pill 1.1 1.4 3.8 0.9 -0.9 1.4 1.2 -0.9 -0.9 -0.4 -1.5 -1.2 0.8 0.4 0.8 1.8 1.3 0.5 1.2 1.1 1.6 1.9
Diastolic blood pressure, automated reading 0.2 0.7 2.3 0.8 1.5 -0.6 -0.7 1.5 0.3 -0.2 -0.2 -0.5 0.8 -0.4 1.4 0.1 -0.8 1.0 -0.5 -1.3 0.3 -0.1
Ever depressed for a whole week 0.2 0.3 1.2 0.8 0.2 -0.2 -0.5 -0.7 0.3 0.7 0.3 0.6 -0.1 0.7 0.7 -0.2 -0.2 -0.4 -0.3 -1.1 0.1 0.2
Unable to work because of sickness or disability 1.6 2.1 7.5 -1.0 -1.5 -0.2 2.7 -1.4 -1.8 -0.9 0.1 0.3 0.8 -0.4 -1.1 0.6 2.6 1.0 2.7 1.3 1.4 1.5
Commuting to job workplace: Cycle 1.2 1.4 3.5 1.1 -1.5 1.9 0.8 -0.9 -0.6 -0.9 -0.8 -1.1 1.3 1.3 0.7 0.4 0.9 1.8 1.0 1.4 0.8 1.8
Myopia 0.2 0.3 1.7 -0.1 0.5 -0.2 -0.1 -0.3 -0.7 -1.2 0.2 1.0 0.9 -0.2 -0.5 -0.1 -0.2 1.3 -0.4 -0.1 -0.2 -0.3
Vascular/heart problems diagnosed by doctor 0.9 2.4 12.5 2.7 -1.4 3.5 0.5 -1.6 -1.0 1.1 -1.1 0.2 -0.3 1.3 2.3 1.5 0.7 0.4 0.8 2.5 0.0 0.9
Cholesterol lowering medication 1.4 2.0 10.5 -1.7 1.9 -1.1 -0.4 -2.8 -0.6 0.1 3.2 -0.8 1.2 -0.4 -2.3 -0.2 -0.4 0.4 -1.4 0.4 0.8 1.0
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.6 -1.7 0.8 -1.7 -0.9 0.3 1.8 1.2 0.2 0.2 1.5 -1.0 -1.5 -1.9 -0.8 -1.8 -0.2 -1.6 -0.9 -1.3
Pain experienced in last month 0.5 0.8 2.3 -0.4 -0.8 0.4 0.6 1.5 -1.5 -1.5 -1.1 -0.3 -1.4 -0.3 0.1 -0.4 0.7 0.7 1.4 0.3 -0.8 -0.8
Supplements: Calcium 0.4 0.4 1.9 1.4 -0.7 0.2 -0.1 0.2 0.2 0.6 -0.5 0.5 -0.6 1.4 0.5 0.4 -0.1 -1.1 -0.1 0.1 -0.2 0.5
Basal cell carcinoma (self-reported) 0.6 0.7 4.3 -1.0 0.6 -1.0 0.1 -0.6 0.9 1.1 -0.0 0.3 2.1 -0.6 -1.1 -0.2 0.1 -1.7 -0.0 -0.7 0.2 -0.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.9 -1.7 -0.8 -0.1 0.3 0.6 0.6 0.1 0.1 0.3 -0.2 0.8 -1.0 -0.5 0.2 -0.4 0.2 -0.4 -0.5 0.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 10.0 -0.7 2.2 -0.8 -0.8 0.4 1.4 0.0 -0.1 -0.7 3.2 -1.6 0.1 -0.8 -1.1 -0.2 0.3 -0.7 0.8 0.1
Heart disease (siblings) 1.8 2.2 4.6 -1.6 1.1 -0.7 -1.6 -1.5 1.9 1.5 -0.0 2.0 -0.9 1.5 -1.1 -0.0 -1.6 -2.1 -2.1 -1.7 -1.2 -1.7
Alcohol drinker status: Previous 0.3 0.4 2.7 0.1 0.6 -0.3 0.1 -0.3 0.5 0.7 -0.1 -0.6 -1.6 0.2 -0.1 0.5 0.1 -0.5 -0.3 -0.3 1.3 0.9
Pack years of smoking 1.0 1.4 4.9 -2.2 0.3 -1.1 -0.8 -0.3 -1.2 -1.6 -0.0 0.4 0.2 -1.4 -1.6 -0.8 -0.8 0.7 -1.2 -1.7 -1.1 -1.9
Impedance of whole body 0.3 1.7 10.8 1.2 -2.9 0.1 1.1 1.4 -0.3 0.1 0.0 0.2 -3.3 0.7 0.3 -0.3 1.2 0.0 0.2 1.1 -2.0 -0.3
Leg fat mass (left) 0.4 1.6 7.7 -2.8 1.9 -0.6 -1.5 -0.8 -0.2 -1.4 -0.0 0.5 0.9 -1.6 -1.4 -0.3 -1.6 0.6 -1.3 -1.2 -0.5 -1.4
Arm predicted mass (left) 0.3 1.7 7.6 -1.4 2.3 0.1 -1.8 -0.9 0.4 -0.7 -0.4 -1.1 2.8 -1.1 -0.2 -0.6 -1.9 0.6 -1.0 -2.0 0.1 -1.0