Hub : Genes

SLC22A23

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1280 0.0400 7.7e-04 -0.003 NA 0.027 NA 0.006 6.6e-01 NA 2.8e-03 NA 9.0e-02
2 GTEx Artery Aorta 0.2380 0.0810 3.4e-03 -0.005 NA -0.005 NA -0.002 9.4e-01 NA 9.7e-01 NA 4.3e-01
3 GTEx Esophagus Muscularis 0.2040 0.0660 2.4e-03 0.000 NA -0.004 NA -0.001 3.4e-01 NA 7.8e-01 NA 3.7e-01
4 METSIM Adipose 0.0746 0.0246 7.5e-04 -0.002 0.025 0.009 0.022 -0.002 7.1e-01 9.9e-05 1.4e-02 2.4e-04 9.6e-01
5 NTR Blood 0.0216 0.0086 5.9e-03 0.000 0.002 -0.001 0.002 -0.001 2.5e-01 4.3e-02 8.6e-01 6.3e-02 7.6e-01
6 ROSMAP Brain Pre-frontal Cortex 0.2088 0.0359 4.2e-15 0.135 0.161 0.154 0.163 0.131 5.1e-17 3.9e-20 2.8e-19 1.8e-20 1.8e-16
7 TCGA Brain Lower Grade Glioma 0.0465 0.0216 3.6e-03 0.043 0.017 0.014 NA 0.029 1.1e-05 4.4e-03 9.6e-03 NA 2.9e-04
8 TCGA Prostate Adenocarcinoma 0.0696 0.0376 9.9e-03 0.038 0.015 0.016 NA 0.026 7.4e-05 8.9e-03 7.2e-03 NA 9.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.4 0.6 3.1 -0.4 0.6 0.4 -0.3 0.7 1.8 0.6 -0.5
Bipolar Disorder or Schizophrenia 0.5 1.2 8.0 0.2 0.6 -0.3 0.5 0.4 2.8 0.7 -0.8
Depressed Affect (Nagel 2018) 1.1 2.4 8.5 -0.6 -2.3 -2.9 0.7 -1.8 -0.7 0.2 -0.8
Depression (Nagel 2018) 0.9 1.3 5.5 1.3 -2.3 -1.2 -0.9 -0.4 -0.0 0.2 -1.1
Intelligence (Savage-Jansen 2018) 1.0 3.1 10.2 -0.2 3.1 3.2 1.0 1.1 1.2 -0.5 0.9
Neuroticism (Nagel 2018) 0.4 1.0 4.0 -0.1 -0.7 -2.0 1.5 -0.9 -0.1 -0.8 0.0
Schizophrenia (2018) 0.4 0.9 4.9 0.7 0.3 -0.7 1.0 -0.1 2.2 0.4 -0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.4 0.3 0.0 0.2 0.6 0.1 0.4 -0.4 0.6
Worry (Nagel 2018) 0.2 0.4 1.5 -0.1 0.0 -1.2 1.0 -0.0 0.6 -0.6 0.3
Alzheimer’s Disease (in mother) 0.9 1.0 3.8 0.7 0.4 1.0 0.5 -0.3 -0.1 1.5 -1.9
Alzheimer’s Disease (in father) 2.2 2.4 5.7 0.0 1.6 2.4 0.8 2.4 1.8 -0.9 0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 2.9 0.4 0.5 1.7 0.3 0.6 0.1 0.8 -1.1
Crohns Disease (2017) 2.1 4.6 9.2 2.7 3.0 0.9 -0.7 1.9 1.0 2.6 -2.8
Irritable Bowel Disease (IBD) 1.0 2.3 4.8 2.2 2.1 0.1 -1.3 0.7 0.2 1.8 -1.8
Ulcerative Colitis (UC) 0.3 0.5 1.5 0.8 0.6 -0.5 -1.2 -0.7 -0.5 0.6 -0.5
Major Depression (MDD) 0.1 0.1 0.3 0.3 -0.0 -0.2 -0.3 -0.5 -0.4 0.4 -0.6
Reaction Time 0.4 0.7 1.8 0.2 1.3 -1.1 0.0 -0.8 -0.9 -0.8 0.8
Verbal and Numeric Reasoning (VNR) 0.8 1.8 5.7 -0.6 2.3 2.4 -0.2 0.4 1.4 1.0 -0.6
Breast Cancer 0.6 1.4 3.7 -0.7 -0.9 -0.6 1.0 0.6 1.1 -1.9 1.9
Ovarian Cancer 0.1 0.1 0.3 -0.2 -0.0 -0.1 0.0 0.3 -0.6 0.4 -0.5
Prostate Cancer 0.3 0.4 1.8 -0.4 -0.7 -0.5 0.3 -1.3 -0.5 0.4 -0.3
Age at First Birth 0.7 1.0 3.1 -1.6 0.9 0.8 -0.8 0.0 -1.8 0.2 0.1
Bipolar Disorder (2011) 0.3 0.3 1.5 -0.0 0.0 -0.8 -0.6 -0.4 1.2 -0.3 0.1
Body Mass Index (BMI) (2010) 2.1 2.8 10.0 1.5 -1.4 -0.6 1.9 0.8 3.2 1.5 -1.2
Coronary Artery Disease (CAD) 1.7 2.0 4.8 1.3 -1.7 -1.5 1.2 -2.2 -1.0 -1.3 0.8
Crohns Disease (2012) 2.6 4.1 10.3 2.3 3.2 1.4 -0.6 1.7 2.2 1.9 -1.9
Mean Putamen Volume 1.1 1.2 3.1 0.9 1.8 0.2 -1.4 1.3 0.9 0.8 -0.9
Fasting Glucose 2.3 2.8 7.1 1.6 0.3 -1.8 -1.2 -0.8 -1.0 2.7 -2.5
HbA1C 1.2 1.3 4.5 2.1 -1.7 -0.3 -0.1 0.8 1.5 -0.5 0.2
HDL Cholesterol 1.0 1.7 5.0 0.1 1.1 2.2 2.2 0.4 -0.4 -1.3 0.9
LDL Cholesterol 0.3 0.5 2.7 0.3 0.3 -0.5 -1.6 0.1 0.7 0.6 -0.4
Lupus 1.2 1.9 4.6 0.6 1.0 1.8 0.6 -0.1 0.7 2.1 -2.1
Neuroticism (2016) 0.5 0.8 3.3 -0.0 -0.2 -1.2 -0.1 -1.8 -0.8 0.5 -0.8
Primary Biliary Cirrhosis 1.7 2.5 7.9 -1.0 0.6 1.3 1.0 0.6 0.3 -2.7 2.8
Rheumatoid Arthritis 0.8 1.1 2.4 -0.3 0.9 1.0 0.3 0.8 1.4 1.5 -1.5
Schizophrenia (2014) 0.9 2.0 9.1 0.9 1.8 -0.6 1.3 0.1 3.0 0.4 -0.6
Triglycerides 0.4 0.7 4.6 0.1 -2.1 -0.6 -0.6 -0.1 0.0 -0.5 0.4
Type 2 Diabetes (T2D) (2012) 1.9 2.2 5.9 2.4 -0.7 -0.9 0.5 0.2 1.0 2.0 -2.2
Ulcerative Colitis 0.3 0.4 1.6 0.7 0.4 1.3 -0.8 -0.1 -0.6 0.4 -0.2
Blood Eosinophil Count 0.2 1.4 4.1 1.3 0.1 -0.3 0.9 -1.3 0.5 2.0 -1.7
Blood Platelet Count 0.4 4.6 7.8 0.7 2.8 2.4 -1.6 1.8 -1.8 2.8 -2.5
Blood Red Count 0.5 4.8 11.8 -0.9 -1.7 -1.2 3.4 2.5 1.6 -2.5 2.5
Blood White Count 0.3 2.1 6.7 2.0 -2.6 -1.4 0.4 -1.2 1.2 0.9 -0.7
Heel T-Score 0.1 0.9 3.2 1.8 0.1 0.1 -0.7 -0.2 0.3 1.0 -1.4
BMI 0.4 2.2 7.3 1.8 -2.7 -2.0 -0.5 -1.0 0.5 0.6 -0.9
Height 0.0 0.9 3.0 1.6 0.6 0.2 -0.5 0.2 1.7 0.9 -0.3
Waist Hip Ratio (WHR) 0.5 2.3 4.5 0.6 -1.7 -2.1 -0.4 -2.1 -0.6 1.8 -1.7
Systolic Blood Pressure 0.2 0.9 3.1 0.2 1.1 1.0 -1.1 1.8 -0.0 -0.5 -0.0
Smoking Status 1.0 2.4 5.5 2.3 -0.9 -0.9 -0.1 -1.4 0.6 2.2 -2.3
Allergy or Eczema 0.4 1.0 2.4 0.6 1.6 1.0 -1.0 0.5 0.2 1.4 -0.9
Cardiovascular Disease 0.1 0.3 1.3 0.3 -1.1 -0.1 0.2 0.6 0.6 0.1 -0.3
Hypothyroidism (self reported) 0.2 0.5 1.3 0.6 -1.1 -0.3 1.1 -0.8 0.6 -0.4 0.1
Respiratory disease 0.3 0.6 1.8 0.6 1.3 0.8 -1.1 -0.0 0.2 0.3 -1.0
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.7 -0.5 -0.9 -0.7 2.0 -2.2 -0.6 -0.2 0.2
Lung FEV1/FVC ratio 0.4 2.1 4.8 2.2 -0.6 0.9 2.1 1.1 2.0 0.4 -0.7
Lung FVC 0.6 3.2 7.9 0.0 -2.1 -2.7 -1.6 -2.8 -0.8 1.5 -0.6
Neuroticism 0.5 1.2 5.8 -0.2 -0.2 -2.4 0.5 -1.4 -1.3 -0.3 -0.2
Chronotype (morning person) 1.4 3.1 10.3 -0.2 -2.1 -0.2 0.9 0.5 3.2 -2.0 2.3
Hair Pigment 0.4 11.0 34.3 1.1 -5.9 -5.8 -1.3 -4.0 0.5 0.9 -0.1
Tanning 0.1 1.6 3.0 0.9 1.0 1.7 -0.1 1.7 -1.0 0.9 -1.7
Hand grip strength (left) 1.8 4.7 20.1 0.1 4.5 1.2 -3.4 1.7 1.2 0.0 0.2
Number of treatments/medications taken 1.4 2.5 5.7 2.4 0.7 0.5 0.3 0.9 1.7 2.1 -2.3
Average weekly spirits intake 0.6 0.7 2.4 0.9 -1.5 -0.9 -0.6 0.0 -0.2 0.8 -0.8
Sensitivity / hurt feelings 0.8 1.3 4.3 -0.7 0.7 -0.9 0.1 -1.1 -2.1 1.1 -1.4
Frequency of depressed mood in last 2 weeks 1.2 1.7 4.3 0.2 -1.8 -1.6 -1.4 -1.1 -2.1 0.2 -0.7
Hearing difficulty/problems: Yes 1.1 1.7 5.1 0.1 -1.6 -2.3 -0.1 -2.2 -0.2 -0.8 0.7
Relative age of first facial hair 0.5 1.0 2.8 -0.4 -0.7 1.7 -0.4 -1.5 -1.5 0.3 -0.2
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 5.8 1.5 0.3 1.0 0.7 -0.3 -0.6 1.7 -2.4
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.1 1.0 -0.2 1.0 0.1 -0.1 0.0 1.5 -1.8
Ever had hysterectomy (womb removed) 1.7 1.9 5.0 0.4 2.2 0.5 -0.7 0.2 0.2 2.2 -2.1
Systolic blood pressure, automated reading 0.3 0.8 1.5 1.2 -0.9 0.5 -0.7 0.6 -1.1 0.5 -1.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.5 -0.4 -1.6 0.4 1.5 0.3 0.4 0.4 -0.4
Angina 1.4 1.8 6.5 0.9 0.2 0.4 -1.7 -0.5 -0.0 2.5 -2.0
Medication for hormone replacement therapy 1.3 1.5 4.0 1.7 1.1 -0.6 -0.9 0.3 2.0 1.3 -0.9
Vitamin and mineral supplements 1.4 1.9 8.3 -1.5 -2.9 -0.9 -1.0 -1.2 -0.8 0.4 -0.5
Supplements: Zinc 0.4 0.5 1.9 1.2 1.4 -0.1 -0.5 0.3 0.3 -0.4 0.3
Medication: Co-codamol 2.1 2.5 5.9 1.3 -1.7 0.6 1.2 -1.3 1.0 2.4 -2.2
Medication: Metformin 0.3 0.4 1.4 0.7 -0.4 -0.5 0.1 -1.0 -1.2 -0.2 0.1
Diabetes (father) 0.4 0.5 1.1 0.3 0.9 0.9 1.1 0.1 -0.1 -0.7 0.6
Diabetes (mother) 0.7 0.8 2.1 1.1 -0.2 -1.5 -0.0 -0.8 0.1 1.1 -1.2
Severe depression (siblings) 0.3 0.3 1.3 1.2 0.2 0.8 0.0 -0.2 0.3 0.3 -0.4
Pack years adult smoking proportion 2.0 3.1 8.7 2.9 0.9 -2.0 -1.1 -0.2 0.7 2.1 -2.4
Impedance of leg (right) 0.1 0.3 1.1 0.9 0.1 -1.1 0.2 0.2 0.5 0.3 -0.2
Leg fat-free mass (left) 0.0 0.2 0.6 -0.0 -0.2 0.6 -0.1 -0.4 -0.1 -0.4 0.8
Trunk fat percentage 0.8 3.0 6.2 2.5 -2.4 -1.8 1.8 -1.8 0.5 0.9 -1.3
Hand grip strength (right) 1.4 3.9 11.9 -1.1 3.3 0.8 -3.4 1.8 0.4 -1.0 1.2
Townsend deprivation index at recruitment 1.4 2.0 6.1 1.1 -1.6 -1.4 0.4 -2.5 -0.5 1.4 -1.3
Current tobacco smoking 2.0 3.3 8.0 2.1 0.1 -1.4 -1.7 -1.2 -0.2 2.8 -2.8
Average weekly fortified wine intake 0.3 0.4 1.5 -1.2 0.1 0.4 0.9 -0.2 -0.0 0.4 -0.6
Maternal smoking around birth 0.8 1.1 2.6 1.2 -0.8 -1.5 -0.4 -0.0 1.6 1.0 -0.8
Fed-up feelings 1.4 2.5 5.4 0.4 -1.9 -2.3 0.1 -1.7 -0.3 1.8 -2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 5.7 0.6 -2.4 -1.2 -0.2 -1.5 -0.0 0.2 -0.7
Relative age voice broke 0.8 1.3 2.6 0.1 1.5 1.4 -0.5 -0.6 -0.2 1.6 -1.6
Taking other prescription medications 1.0 1.6 5.5 1.0 -1.4 -0.4 1.7 -2.3 -0.3 0.8 -0.8
Age when periods started (menarche) 0.5 1.2 2.6 0.5 1.6 0.6 0.3 1.3 1.2 1.1 -1.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 3.0 0.1 0.1 -0.6 -0.5 -0.2 0.6 1.7 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.8 0.1 -0.3 -0.9 1.4 -0.2 1.0 0.3 0.1
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 6.5 2.5 -0.0 -0.7 0.3 -0.3 0.8 0.3 -0.2
Qualifications: CSEs or equivalent 1.2 1.6 6.0 0.0 -2.1 -0.7 2.4 0.5 0.4 -1.0 0.8
Serious illness, injury or assault to yourself 0.9 1.1 3.0 0.9 0.4 1.6 0.6 -1.7 -0.2 0.7 -1.0
High blood pressure 0.6 1.6 5.3 0.8 -0.6 -1.2 -1.1 0.0 0.2 2.0 -2.3
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.7 0.5 1.4 1.4 -1.9 -0.1 -1.0 1.8 -1.5
Multivitamins +/- minerals 0.9 1.2 7.1 1.4 2.7 0.1 0.1 -0.2 -0.2 0.3 -0.2
Stomach or abdominal pain in last month 1.1 1.3 3.2 0.7 -1.0 -1.7 -0.0 -0.8 0.0 1.6 -1.8
Supplements: Glucosamine 1.5 1.9 5.0 1.1 -0.5 2.2 1.1 2.0 1.9 -0.0 0.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.9 -0.8 -0.2 1.0 0.9 0.9 1.1 1.4 -0.9
Medication: Atenolol 0.4 0.5 1.6 -0.7 0.4 -0.1 -0.2 0.1 0.2 1.3 -1.3
Medication: Levothyroxine sodium 0.9 1.5 3.4 0.8 -1.8 -0.7 -0.2 -1.5 -0.2 1.6 -1.8
Sitting height 0.4 3.0 7.5 -1.1 2.4 2.7 0.6 0.5 0.7 -1.6 2.3
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 0.9 -0.9 -0.0 -0.1 0.5 1.3 1.1 -1.0
High blood pressure (mother) 0.8 1.1 2.4 -0.7 0.1 -0.0 -0.2 1.3 -1.6 -1.5 1.4
Body mass index (BMI) 0.4 1.8 4.5 2.0 -2.1 -1.6 0.7 -1.4 -0.1 0.6 -1.0
Impedance of leg (left) 0.1 0.7 1.9 1.4 0.1 -0.6 0.2 0.6 1.2 0.7 -0.9
Leg predicted mass (left) 0.0 0.2 0.7 -0.1 -0.2 0.5 -0.1 -0.4 -0.1 -0.5 0.8
Trunk fat mass 0.5 2.3 5.8 2.4 -2.1 -1.5 1.2 -1.5 0.7 0.8 -1.1
Waist circumference 0.8 3.0 8.7 1.9 -3.0 -1.4 1.0 -2.3 -0.3 1.1 -1.3
Number of incorrect matches in round 2.9 4.9 11.5 -0.4 -3.4 -3.0 1.9 0.0 0.6 -2.7 2.7
Past tobacco smoking 0.5 0.9 3.1 -1.8 0.4 0.4 -1.1 0.2 -1.4 -0.5 0.8
Alcohol usually taken with meals 1.0 1.6 5.0 -1.8 1.5 2.2 -0.7 1.1 0.2 -0.4 0.5
Nervous feelings 0.5 0.9 2.1 -0.8 -1.0 -1.2 1.4 -0.6 -1.0 -0.7 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 1.0 -0.1 -1.0 -0.5 -0.2 -0.0 0.5 -0.1 -0.0
Hearing difficulty/problems with background noise 0.7 1.0 2.8 0.9 -0.4 -1.7 0.3 -1.4 0.8 -0.9 1.0
Hair/balding pattern: Pattern 2 1.1 1.4 8.1 -2.8 0.4 0.2 0.1 0.1 -1.3 -0.8 0.9
Had menopause 1.8 2.2 5.1 1.6 0.3 1.6 1.6 1.2 2.3 1.4 -1.4
Had other major operations 2.3 2.8 5.9 -1.2 2.4 2.0 -2.3 1.4 0.3 1.3 -1.3
Forced vital capacity (FVC) 0.3 1.2 4.6 -1.1 0.3 -1.1 -0.9 -0.4 0.5 -1.2 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.6 0.9 0.2 0.0 1.3 0.6 1.1 0.4 -0.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 0.1 0.0 -1.4 -1.0 0.1 0.5 0.8 -0.8
Qualifications: None of the above 1.8 3.8 11.2 3.3 -2.6 -2.1 -0.3 -1.2 1.9 1.1 -1.2
Financial difficulties in last 2 years 1.0 1.3 3.6 0.8 -1.6 -1.0 0.6 -1.9 -0.1 1.0 -1.2
Mouth/teeth dental problems 0.4 0.7 2.2 -0.8 1.5 0.6 -0.7 0.7 -0.7 -0.6 0.8
Heart attack 0.4 0.5 2.5 0.7 0.4 0.2 1.6 -0.4 0.4 0.4 -0.4
Allergy 0.8 1.9 3.4 -0.6 -1.2 -1.5 1.9 0.5 1.5 -1.6 1.5
Pain all over the body in last month 1.0 1.0 2.7 1.2 -0.5 0.2 -1.0 -0.1 0.3 1.6 -1.6
Diabetes (self-reported) 0.5 0.8 2.6 0.7 -0.9 -1.2 1.6 -0.9 0.1 0.0 -0.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.2 1.5 1.0 0.2 0.3 1.3 1.3 -0.5 0.8
Medication: Ramipril 0.4 0.5 2.4 -0.7 0.1 -0.0 0.0 -1.1 -1.5 0.3 -0.3
Medication: Simvastatin 0.3 0.5 1.9 -0.3 1.1 0.7 1.4 -0.0 -0.6 0.3 -0.3
Fluid intelligence score 0.9 1.8 8.6 -0.4 2.9 1.7 -0.4 0.9 0.8 -0.4 0.7
Illnesses of siblings 0.6 0.8 4.4 -2.1 -0.6 0.7 0.8 0.4 0.6 -0.0 0.2
Neuroticism score 0.6 1.3 5.8 -0.3 -0.6 -2.4 0.2 -1.3 -0.8 0.8 -1.2
Weight 0.2 1.0 2.8 1.7 -1.5 -0.5 0.8 -1.2 0.7 0.3 -0.3
Impedance of arm (right) 0.3 1.5 6.4 -1.1 -0.1 -0.9 2.5 -1.2 -0.1 -1.1 1.1
Arm fat percentage (right) 0.8 3.2 7.1 1.6 -2.3 -2.7 1.7 -2.3 -0.2 0.8 -1.2
Trunk fat-free mass 0.1 0.3 1.7 0.1 0.4 0.2 -1.3 0.0 0.1 -0.2 0.6
Hip circumference 0.2 0.7 2.6 0.8 -1.0 0.1 1.0 -1.6 -0.3 -0.1 0.1
Time employed in main current job 1.8 2.1 4.3 1.5 1.7 -0.6 -1.3 -1.7 -0.7 1.5 -2.1
Alcohol intake versus 10 years previously 2.5 3.7 14.0 3.7 -0.7 -2.6 0.6 -0.9 1.5 1.7 -1.5
Father’s age at death 0.8 1.1 3.2 -1.8 1.2 1.0 -0.6 0.4 -1.3 0.7 -0.8
Worrier / anxious feelings 0.4 0.7 2.6 -0.1 -1.0 -1.6 0.5 -0.1 0.9 0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 11.8 1.0 -3.4 -1.0 0.3 -1.0 0.3 1.1 -1.1
Falls in the last year 1.8 2.4 8.1 2.9 -1.0 0.7 -0.5 -0.1 2.0 1.7 -1.6
Hair/balding pattern: Pattern 3 0.6 1.0 3.7 1.9 -0.3 -0.1 0.8 -0.3 0.5 1.0 -1.4
Number of live births 0.5 0.8 2.1 -0.2 -0.7 -0.2 1.0 1.5 -0.2 -1.2 1.0
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.4 -1.5 0.2 -0.4 -0.5 -0.1 0.4 -1.1 1.9
Pulse rate 0.1 0.2 0.5 0.6 -0.7 -0.6 -0.0 -0.6 0.4 -0.2 0.4
Happiness 0.9 1.1 4.3 -0.8 -0.1 -0.3 -0.9 1.5 -2.1 0.5 -0.6
Noisy workplace 0.4 0.5 2.0 0.1 -0.4 -1.4 -0.8 -0.5 -0.0 0.4 -0.6
Qualifications: A levels/AS levels or equivalent 2.4 5.2 13.3 -2.1 3.5 3.6 -1.2 1.8 0.1 -1.5 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.4 -1.0 0.2 0.8 -1.6 -1.1 -1.0 -0.6 0.4
Mouth/teeth dental problems: Dentures 0.5 0.8 2.5 1.6 -0.0 -0.8 -0.0 -0.4 0.1 1.1 -1.3
Asthma 0.4 0.7 2.5 0.1 1.4 1.6 -1.0 0.3 -0.4 -0.2 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.5 0.8 1.0 1.5 -0.2 1.6 -0.2 0.6 -0.4
Medication: Cholesterol lowering 0.9 1.4 3.9 1.0 1.4 -0.8 -0.2 -0.8 -0.6 2.0 -1.6
Depression (self-reported) 0.5 0.7 1.4 -0.8 -0.9 -1.2 1.1 -0.9 -0.5 -0.0 0.3
Medication: Lansoprazole 0.6 0.6 2.5 -0.7 -1.6 0.6 0.8 0.8 0.4 0.3 -0.5
Prospective memory result 2.0 2.4 8.2 -0.6 -2.9 -2.3 0.2 -1.8 -1.1 -0.8 0.4
Lung cancer (father) 1.5 1.7 5.3 1.0 -1.6 0.2 0.4 -0.8 0.8 1.9 -2.3
Illnesses of mother 0.4 0.4 1.4 -0.9 0.7 0.5 -0.3 -1.2 0.0 -0.5 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.7 -0.7 0.4 1.2 -0.5 0.8 0.5 -0.6 1.3
Pulse wave Arterial Stiffness index 0.6 0.7 2.9 0.4 0.9 -0.4 0.2 0.1 0.6 1.7 -1.2
Impedance of arm (left) 0.4 1.7 4.2 -1.9 -0.2 -0.3 2.1 -1.2 -0.7 -1.4 1.4
Arm fat mass (right) 0.5 2.0 4.9 1.5 -2.2 -1.9 1.0 -1.8 -0.2 0.5 -0.9
Trunk predicted mass 0.1 0.3 1.6 0.1 0.4 0.2 -1.3 -0.0 0.1 -0.2 0.7
Standing height 0.2 1.5 4.3 -0.6 1.5 2.1 -0.1 0.4 1.5 -0.8 1.5
Length of working week for main job 0.4 0.4 2.1 1.5 -0.0 -0.4 0.3 -0.0 0.4 -0.3 0.8
Exposure to tobacco smoke at home 3.3 3.7 8.5 1.4 0.1 -2.6 -1.6 -2.9 -1.2 1.8 -2.2
Breastfed as a baby 1.6 2.0 7.5 0.8 1.0 1.1 -1.6 2.7 0.2 1.2 -1.3
Tense / ‘highly strung’ 0.6 1.0 4.8 -0.1 -0.6 -2.2 0.9 -1.0 0.9 -0.2 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 4.1 -0.2 -1.9 -0.2 1.6 -0.0 2.0 -0.5 0.3
Hair/balding pattern: Pattern 4 0.5 1.1 2.4 -0.3 -1.5 -1.0 -0.4 -0.1 1.2 -1.2 1.6
Birth weight of first child 0.3 0.5 1.6 1.3 -0.9 -0.6 -0.2 -0.3 1.0 0.1 0.3
Peak expiratory flow (PEF) 0.6 1.5 3.0 -0.8 1.7 1.7 -0.8 1.1 0.1 -1.1 1.4
Pulse wave reflection index 0.5 0.6 2.6 -0.5 1.6 0.7 0.4 -0.1 0.8 0.9 -0.3
Ever highly irritable/argumentative for 2 days 2.7 3.2 9.5 3.1 0.7 0.6 1.2 1.6 2.9 0.9 -1.5
Loud music exposure frequency 0.2 0.2 0.4 -0.3 -0.4 -0.7 -0.2 0.1 0.6 -0.5 0.6
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.6 -1.5 1.5 0.8 -0.2 0.2 -0.7 -1.3 1.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.8 -0.5 -1.3 0.7 0.6 0.3 0.7 -0.2 0.4
Blood clot in the leg (DVT) 1.2 1.6 3.6 1.6 -0.1 1.5 -0.3 -0.6 0.7 1.8 -1.9
Medication: Paracetamol 0.6 1.0 1.7 1.1 -1.1 1.0 0.1 -1.0 0.7 1.3 -1.0
Headache pain in last month 1.0 1.7 5.6 1.5 1.4 1.1 -0.3 1.3 2.4 0.7 -0.7
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 5.1 -1.2 -1.2 1.4 0.3 0.4 -0.1 -2.2 2.3
Glaucoma (self-reported) 0.3 0.3 0.5 0.6 0.3 0.7 0.3 0.3 0.7 0.7 -0.6
Gout (self-reported) 0.8 1.1 2.3 -0.3 -1.5 0.6 0.3 -0.7 -1.2 -1.1 1.5
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.4 1.6 -0.5 -0.5 0.6 -1.4 -0.2 0.8 -1.1
Medication: Amlodipine 1.0 1.4 4.9 -2.2 -1.2 -1.0 -0.7 -0.6 -1.2 -0.8 1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.6 -0.3 0.9 -0.6 -0.6 -0.9 0.3 -0.6
Birth weight 0.5 1.1 3.3 -1.6 -0.6 -0.5 -1.8 -0.9 -0.4 -0.4 1.0
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.1 2.0 -0.6 -0.9 -1.5 -0.4 1.4 1.6 -1.3
High blood pressure (siblings) 0.6 0.9 1.6 1.0 0.1 -1.3 -1.2 -1.3 -1.1 -0.3 0.3
Forced vital capacity (FVC), Best measure 0.1 0.5 1.5 -0.4 0.6 0.5 -1.2 0.2 0.1 -0.4 1.2
Body fat percentage 0.9 3.6 7.3 2.6 -2.7 -2.2 1.5 -1.9 0.4 1.1 -1.7
Leg fat percentage (right) 1.1 3.9 8.5 2.8 -2.9 -2.6 0.8 -1.6 0.5 1.2 -1.6
Arm fat-free mass (right) 0.1 0.6 1.8 0.8 0.4 1.3 -1.3 0.7 0.4 0.0 0.2
Exposure to tobacco smoke outside home 1.3 1.7 9.8 0.1 -0.8 -3.1 0.2 -0.3 1.8 0.2 -0.1
Comparative body size at age 10 0.3 0.9 2.7 0.5 1.6 1.3 0.6 0.9 0.7 0.7 -0.6
Number of full brothers 1.3 1.6 4.8 1.4 0.7 0.5 -2.2 1.1 1.7 1.0 -0.5
Worry too long after embarrassment 0.6 1.0 2.8 0.5 1.7 0.2 1.4 1.0 -0.4 0.8 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 6.1 0.4 0.5 -1.6 0.5 0.1 2.5 0.1 0.3
Wheeze or whistling in the chest in last year 1.9 3.3 9.3 1.0 -0.6 -0.9 -2.0 -2.0 -0.6 2.6 -3.1
Number of children fathered 1.5 1.7 3.7 -0.1 0.5 1.4 1.4 1.9 0.9 -1.6 1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 12.7 0.1 3.6 0.5 0.8 0.3 0.7 -0.4 0.5
Age at first live birth 0.7 1.2 3.6 -1.9 -0.1 0.2 -1.0 -1.0 -1.7 -0.5 0.8
Pulse wave peak to peak time 0.5 0.6 2.6 -0.4 -0.7 0.4 -0.2 -0.2 -0.5 -1.6 1.1
Health satisfaction 0.2 0.3 1.1 0.5 0.1 0.6 -0.1 1.1 -0.5 0.2 -0.4
Shortness of breath walking on level ground 0.5 0.6 3.0 1.7 -0.2 -0.8 -0.3 -0.7 0.1 0.4 -0.2
Qualifications: College or University degree 1.9 5.9 17.6 -3.3 4.2 3.2 -0.6 1.3 -0.9 -1.6 1.5
Eye problems/disorders: None of the above 0.3 0.4 1.0 -0.9 1.0 0.2 -0.5 0.3 0.4 -0.7 0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.8 0.3 -1.2 1.9 0.5 0.6 0.2 1.0 -1.5
Emphysema/chronic bronchitis 0.3 0.3 1.1 -0.2 -0.8 1.1 -0.2 0.2 -0.7 0.1 -0.5
Medication for pain relief, constipation, heartburn 1.5 2.5 7.0 -1.9 0.9 -1.1 -0.5 0.7 -0.7 -2.6 2.5
Neck or shoulder pain in last month 0.7 1.0 3.7 0.6 -0.8 0.5 -0.8 1.4 1.9 0.8 -0.0
Medication: Blood pressure 0.9 1.5 5.1 0.3 1.6 -0.7 -0.2 -0.5 -0.0 1.9 -2.3
Angina (self-reported) 1.0 1.3 4.4 0.5 -0.2 0.2 -1.3 -0.9 -0.3 2.1 -1.6
Migraine (self-reported) 0.5 0.6 1.6 -0.1 -0.0 0.8 0.9 1.3 0.7 -0.9 0.6
Medication: Ibuprofen 1.2 1.4 4.5 1.0 1.2 2.1 -0.5 1.5 -0.4 0.9 -0.8
Medication: Allopurinol 2.0 2.7 8.9 -0.5 -0.9 -0.0 -0.2 -3.0 -2.9 -1.2 1.4
Medication: Omeprazole 1.9 2.2 5.1 2.3 -0.2 0.1 0.7 -0.9 1.5 2.1 -2.2
Medication: Seretide 50 evohaler 0.4 0.5 2.4 -0.4 -0.0 0.7 -1.6 0.1 0.2 0.5 -0.7
Mean time to correctly identify matches 0.3 0.6 2.3 0.0 0.0 -1.5 0.7 -1.4 -0.6 -0.1 -0.0
Heart disease (mother) 1.0 1.2 4.1 -0.6 -1.6 -2.0 -0.1 -0.4 -1.4 -0.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.6 -1.6 0.5 0.6 -1.0 0.2 -1.1 -0.8 0.7
Whole body fat mass 0.6 2.5 5.6 2.4 -2.3 -1.7 1.0 -1.5 0.4 0.9 -1.3
Leg fat mass (right) 0.7 2.6 6.2 2.4 -2.5 -1.8 0.4 -1.3 0.5 1.2 -1.4
Arm predicted mass (right) 0.1 0.7 1.7 1.2 0.3 1.2 -1.3 0.7 0.6 0.1 0.2
Pulse rate, automated reading 0.3 0.9 3.3 1.0 -1.8 -1.1 0.2 -1.1 -0.4 -0.2 0.1
Alcohol intake frequency. 0.7 1.7 3.3 1.8 -1.5 -1.7 1.2 -1.5 0.4 0.7 -0.9
Comparative height size at age 10 0.2 1.0 5.7 1.0 -0.3 0.3 0.6 -0.6 2.4 0.5 0.3
Number of full sisters 0.7 0.8 2.5 0.9 1.1 0.3 -0.5 0.0 0.2 1.3 -1.6
Suffer from ‘nerves’ 0.1 0.1 0.5 0.2 -0.1 -0.7 0.5 -0.4 0.0 -0.0 0.1
Overall health rating 1.5 3.2 10.2 2.0 -1.6 -0.4 0.3 -0.9 -0.5 2.7 -3.2
Chest pain or discomfort 1.7 2.5 5.8 0.8 0.8 0.6 -2.3 -1.4 -0.3 2.2 -2.4
Had major operations 0.6 0.7 1.4 -0.6 -0.7 -0.7 0.7 1.1 1.2 -0.9 0.7
Age at last live birth 1.4 2.1 7.0 -2.6 -1.4 -0.2 -1.0 -1.1 -2.1 -0.4 1.0
Family relationship satisfaction 2.6 3.3 10.6 -0.1 1.5 -0.3 -3.2 0.7 -3.2 1.2 -1.0
Leg pain on walking 1.8 2.2 5.0 1.9 -1.2 -2.2 0.5 -0.6 1.4 1.6 -1.6
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 11.6 0.1 -0.8 -3.4 0.1 -1.2 -0.6 -0.6 0.5
Commuting to job workplace: Car/motor vehicle 2.3 2.6 6.0 0.1 -1.8 -1.3 2.4 -1.4 0.2 -1.9 2.0
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.7 0.2 0.3 -0.8 0.3 0.5 0.2 -0.0 0.5
Medication: Aspirin 1.3 1.8 5.6 1.3 0.0 1.2 0.3 0.3 0.5 2.2 -2.4
Supplements: Vitamin C 1.3 1.6 4.0 0.2 0.4 2.0 1.2 1.6 1.0 -1.3 1.4
Knee pain experienced in last month 1.0 1.5 4.4 1.3 -2.1 0.9 1.7 -0.3 1.5 0.2 -0.3
Hypertension (Self-reported) 0.3 0.9 3.1 0.7 -0.5 -0.8 -0.7 0.3 0.4 1.4 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 -0.0 -1.0 0.6 0.2 -0.2 0.9 -0.5 0.7
Illnesses of father: Heart disease 0.4 0.6 2.8 0.1 -1.0 0.3 1.7 0.2 -0.3 -0.6 0.4
Illnesses of siblings: Diabetes 0.4 0.4 1.5 0.3 -0.6 -0.4 1.1 -1.2 -0.0 -0.4 -0.0
Smoking status: Previous 0.2 0.4 1.1 0.8 -0.3 0.1 0.9 0.4 1.0 -0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.9 -0.2 0.9 0.6 -0.7 0.3 0.2 -1.7 2.0
Whole body fat-free mass 0.0 0.2 0.9 0.2 0.1 0.5 -0.9 0.0 0.1 -0.2 0.6
Leg fat-free mass (right) 0.0 0.2 0.9 -0.0 0.1 0.9 -0.2 -0.1 0.2 -0.4 0.7
Arm fat percentage (left) 0.6 2.6 5.3 1.4 -2.3 -2.3 1.6 -2.1 -0.3 0.4 -0.9
Average weekly red wine intake 1.4 2.0 6.3 -0.8 2.5 1.7 -1.0 1.7 0.8 1.1 -0.7
Handedness (chirality/laterality): Left-handed 1.3 1.6 4.8 2.2 0.2 -0.4 -0.1 -0.7 2.0 1.5 -1.2
Mood swings 2.3 4.1 14.3 -0.7 -3.8 -3.5 0.6 -2.1 -0.5 0.1 -0.4
Loneliness, isolation 0.6 0.8 2.9 0.7 -0.3 -0.8 -0.4 -0.5 -0.3 1.4 -1.7
Long-standing illness, disability or infirmity 1.4 2.1 5.3 2.2 0.3 -0.2 1.0 -1.2 0.3 2.1 -2.3
Ever had bowel cancer screening 1.1 1.3 4.7 2.2 -1.0 -0.7 0.5 -0.4 0.8 0.9 -1.6
Diabetes diagnosed by doctor 0.6 1.0 2.8 0.0 -0.7 -1.4 1.6 -1.7 -0.5 -0.3 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.8 0.4 -0.9 -0.4 -0.9 0.4 0.6 0.7 -0.5
Friendships satisfaction 0.4 0.5 2.8 -0.8 0.1 -0.1 -0.3 0.2 -1.7 0.3 -0.4
Qualifications: nursing, teaching 2.3 3.6 13.2 -1.7 2.8 3.6 -1.8 1.3 -0.3 -0.1 0.5
Commuting to job workplace: Walk 0.9 1.0 2.7 0.9 0.2 1.2 -0.2 1.6 1.6 -0.3 -0.1
Eye problems/disorders: Cataract 0.6 0.7 2.3 1.4 -1.5 -1.1 0.2 0.2 -0.1 0.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.6 0.1 -0.1 -0.5 -0.3 -0.7 0.5 0.2 0.1
Medication for cholesterol 0.3 0.5 1.6 -1.3 -0.0 0.5 0.7 0.3 -0.9 -0.7 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 7.1 1.0 -0.6 1.2 0.0 2.7 1.0 1.0 -1.1
Back pain experienced in last month 1.5 2.2 6.7 1.7 -1.5 0.1 0.1 2.0 2.6 0.8 -1.0
Mineral and other dietary supplements 1.8 2.4 7.0 -1.8 -0.6 -2.6 -0.4 -1.9 -2.1 -0.1 -0.0
Breast cancer (self-reported) 1.3 1.5 3.3 0.3 1.4 0.6 -0.9 1.2 1.6 1.8 -1.3
Asthma (self-reported) 0.3 0.6 2.1 0.1 1.3 1.4 -0.9 0.2 -0.5 -0.2 0.0
Osteoporosis (self-reported) 0.6 0.7 3.1 1.8 -0.0 0.6 0.5 0.5 1.4 0.1 -0.1
Osteoarthritis (self-reported) 0.9 1.1 4.7 -0.0 -2.2 1.1 1.3 0.7 0.3 0.4 -0.6
Medication: Aspirin 1.4 1.8 6.1 1.4 0.1 0.8 0.2 -0.1 0.7 2.3 -2.5
Medication: Gliclazide 1.3 1.4 3.3 0.8 -1.5 -1.5 1.1 -1.8 -1.0 0.5 -0.7
Illnesses of father: None of the above (group 1) 0.8 1.0 3.9 -1.1 -0.7 -2.0 -0.6 -1.1 -0.5 -0.4 0.6
Smoking status: Current 1.9 3.1 6.8 2.6 -0.1 -1.4 -0.9 -1.4 0.1 2.5 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.5 0.6 -0.1 0.1 -0.6 -0.6 -0.0 1.6 -0.9
Whole body water mass 0.0 0.2 0.9 0.2 0.2 0.5 -0.9 0.1 0.2 -0.2 0.7
Leg predicted mass (right) 0.1 0.3 1.1 -0.1 0.2 1.1 -0.1 0.0 0.2 -0.5 0.8
Arm fat mass (left) 0.5 1.9 4.2 1.9 -2.1 -1.9 0.8 -1.6 -0.1 0.5 -0.8
Number of self-reported non-cancer illnesses 0.4 0.7 2.4 0.6 -0.4 0.2 0.8 0.1 1.0 1.0 -1.5
Average weekly champagne plus white wine intake 1.4 2.0 6.2 -1.4 -0.6 0.1 -0.7 0.5 -0.7 -2.4 2.5
Miserableness 1.3 2.3 5.4 -0.4 -2.1 -2.3 1.6 -2.1 0.2 0.6 -0.8
Guilty feelings 0.2 0.3 1.3 -0.4 0.1 -1.1 -0.1 -0.4 -0.6 -0.2 -0.2
Wears glasses or contact lenses 1.6 1.9 3.5 -1.3 -1.8 1.3 1.9 -0.7 -0.7 -1.4 1.4
Ever taken oral contraceptive pill 0.8 0.9 2.2 -0.2 1.5 -0.9 0.4 -0.4 -0.4 1.0 -1.5
Hearing aid user 2.5 2.8 6.4 0.1 -1.9 -0.8 1.3 -0.5 2.2 -2.2 2.5
Mother’s age at death 1.0 1.3 2.3 -1.5 1.1 1.3 -0.2 1.3 1.2 -0.6 1.2
Financial situation satisfaction 0.2 0.2 0.9 0.3 0.1 -0.4 0.7 0.3 -1.0 -0.5 0.1
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.4 0.8 -0.8 0.0 0.6 -0.6 -1.2 0.0 -0.4
Commuting to job workplace: Public transport 1.3 1.5 4.9 0.9 1.7 0.0 -2.2 -0.4 -0.1 1.4 -1.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.4 0.5 0.6 0.2 -0.1 0.2 0.4 -0.3
Medication: Blood pressure 0.1 0.2 0.6 0.5 -0.6 -0.4 -0.4 0.0 0.8 -0.1 -0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.7 0.8 0.2 -1.5 1.9 0.2 1.9 0.8 -1.4
Supplements: Fish oil (including cod liver oil) 1.2 1.6 4.1 1.7 0.7 2.0 0.7 1.2 1.6 0.7 -0.6
High cholesterol (Self-reported) 0.4 0.7 2.1 -0.0 -1.4 -0.6 1.4 -0.1 0.7 -0.6 0.6
Medication: Bendroflumethiazide 0.3 0.4 1.4 1.0 -0.3 0.1 -0.2 -0.5 0.7 0.7 -1.2
Medication: Paracetamol 0.5 0.7 2.3 1.4 -0.2 1.5 0.5 -0.5 0.8 0.5 -0.5
Medication: Lisinopril 0.9 1.1 3.2 1.8 1.2 -1.3 0.8 -0.6 0.9 0.4 -1.0
Medication: Atorvastatin 0.8 0.9 1.9 0.9 0.7 -1.4 -0.7 -0.4 1.4 1.0 -0.8
Illnesses of father: High blood pressure 1.1 1.4 4.5 -0.0 0.9 2.1 -0.4 1.9 -1.1 -0.5 0.6
Alcohol drinker status: Never 1.5 1.8 6.9 0.5 -2.1 -0.8 0.7 -2.6 1.1 -0.2 0.4
Ever smoked 0.5 0.8 2.9 1.3 0.2 -1.0 0.0 0.0 1.7 0.7 -0.8
Basal metabolic rate 0.0 0.1 0.5 0.5 -0.3 0.2 -0.7 -0.3 0.1 0.0 0.3
Leg fat percentage (left) 1.2 4.2 9.4 3.1 -2.9 -2.4 1.1 -1.4 1.0 1.4 -2.0
Arm fat-free mass (left) 0.1 0.4 1.5 1.2 -0.3 0.3 -0.9 0.2 0.6 0.2 0.1
Number of operations (self-reported) 0.5 0.7 1.6 -0.8 1.0 1.1 -0.0 1.3 0.7 0.6 -0.4
Average weekly beer plus cider intake 1.1 1.6 5.0 0.9 -2.2 -2.1 0.1 -0.1 -0.9 0.8 -1.1
Irritability 0.9 1.5 4.2 1.3 0.1 -1.5 -0.6 -2.0 -0.9 1.0 -1.3
Risk taking 1.2 1.8 2.9 1.0 0.6 -0.9 -1.6 1.5 1.7 1.7 -1.3
Ever had prostate specific antigen (PSA) test 0.9 1.1 5.5 -0.1 0.8 -2.3 -0.0 -1.0 0.3 -0.9 0.5
Fractured/broken bones in last 5 years 1.3 1.6 3.6 1.6 1.0 0.4 -1.3 -0.7 0.7 1.7 -1.9
Age started oral contraceptive pill 0.6 0.7 1.5 -0.8 1.1 1.2 0.7 0.9 0.3 0.7 -0.8
Diastolic blood pressure, automated reading 0.5 1.6 3.8 1.9 -1.4 -0.8 -1.1 0.2 -0.0 1.5 -1.8
Ever depressed for a whole week 0.4 0.5 2.5 0.6 -0.6 -1.6 0.4 -0.3 0.1 -0.5 0.4
Unable to work because of sickness or disability 2.0 2.6 5.3 2.3 -1.9 -1.5 0.5 -0.4 0.4 2.1 -2.3
Commuting to job workplace: Cycle 1.0 1.3 5.3 0.1 1.3 0.5 -2.3 -0.5 -1.0 1.0 -0.8
Myopia 0.8 1.2 2.9 -1.0 1.4 0.7 0.4 -0.4 -0.2 -1.7 1.6
Vascular/heart problems diagnosed by doctor 0.5 1.5 4.2 -1.4 0.1 0.6 0.2 -0.1 -1.3 -1.9 2.1
Cholesterol lowering medication 0.6 0.9 2.9 0.3 -0.7 1.1 1.7 0.7 1.2 -0.7 0.7
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 6.1 1.8 -0.8 -0.1 0.0 -1.5 0.6 2.3 -2.5
Pain experienced in last month 0.9 1.6 6.4 -1.6 0.9 0.0 -0.2 -1.3 -2.5 -0.9 0.6
Supplements: Calcium 0.6 0.7 1.3 0.9 1.0 1.1 0.2 0.8 0.9 0.7 -0.4
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 -0.3 -0.0 -1.0 0.9 -0.9 -0.5 -1.0 1.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.4 0.6 0.4 0.2 1.6 -0.1 0.5 0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.6 1.3 -0.0 1.9 -0.3 -0.5 0.4 1.6 -1.6
Heart disease (siblings) 1.2 1.5 5.4 2.3 1.4 0.3 -0.3 1.0 1.6 0.7 -0.7
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.4 -0.2 -0.8 -0.1 -0.4 0.5 -0.6 0.2
Pack years of smoking 1.9 2.7 8.8 3.0 0.8 -1.6 -0.8 -0.1 0.7 1.9 -2.3
Impedance of whole body 0.1 0.3 2.0 -0.3 0.1 -0.1 1.4 -0.1 0.4 -0.6 0.5
Leg fat mass (left) 0.7 2.6 6.4 2.5 -2.4 -1.6 0.6 -1.1 0.8 1.2 -1.5
Arm predicted mass (left) 0.1 0.4 1.4 1.2 -0.0 0.6 -1.1 0.3 0.6 0.3 0.0