TWAS hub - SLC25A21

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.111	0.044	1.5e-03	0.023	0.049	0.006	NA	0.020	1.7e-02	8.8e-04	1.3e-01	NA	2.4e-02
2	TCGA	Thyroid Carcinoma	0.145	0.037	1.7e-09	0.123	0.112	0.104	NA	0.109	5.9e-12	5.2e-11	2.7e-10	NA	8.8e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Frequency of tiredness / lethargy in last 2 weeks	10.0	16.3	18.4	-3.8	-4.3
Back pain experienced in last month	9.2	13.5	16.1	-3.3	-4.0
Forced vital capacity (FVC)	8.7	33.7	34.8	-5.7	-5.9
Forced vital capacity (FVC), Best measure	7.8	28.7	29.5	-5.3	-5.4
Forced expiratory volume in 1-second (FEV1)	7.6	25.8	29.0	-4.8	-5.4
Length of working week for main job	7.4	8.2	9.2	-3.0	-2.7
Lung FVC	7.3	37.2	38.5	-6.0	-6.2
Medication: Ibuprofen (e.g. Nurofen)	7.0	8.9	9.6	-3.1	-2.9
Number of incorrect matches in round	6.8	11.3	12.0	3.5	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	6.6	21.2	23.4	-4.4	-4.8
Blood clot in the leg (DVT)	6.4	8.2	9.1	2.7	3.0
Bilateral oophorectomy (both ovaries removed)	6.2	7.1	7.3	-2.7	-2.6
Ever had bowel cancer screening	5.9	7.0	8.2	-2.4	-2.9
Ever used hormone-replacement therapy (HRT)	5.8	7.4	8.1	-2.8	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	5.7	7.4	8.3	-2.9	-2.5
Deep venous thrombosis (DVT) (self-reported)	5.7	7.3	8.7	2.4	3.0
Multivitamins +/- minerals	5.5	7.0	7.3	-2.6	-2.7
Worrier / anxious feelings	5.5	10.4	11.3	3.1	3.4
Long-standing illness, disability or infirmity	5.3	8.1	8.5	-2.9	-2.8
Frequency of depressed mood in last 2 weeks	5.2	7.2	10.1	-2.1	-3.2
Medication for hormone replacement therapy	5.2	5.8	6.1	-2.3	-2.5
Sitting height	5.0	35.2	37.0	-6.1	-5.8
Other serious medical condition/disability diagnosed by doctor	4.8	6.3	7.0	-2.4	-2.6
Vitamin and mineral supplements	4.6	6.2	6.3	2.5	2.5
Supplements: Glucosamine	4.6	6.0	7.4	-2.1	-2.7
Depression (Nagel 2018)	4.5	6.8	9.7	-2.0	-3.1
Heart disease (siblings)	4.3	5.3	5.8	2.2	2.4
Ever had hysterectomy (womb removed)	4.2	4.7	5.3	-2.0	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	8.0	-1.8	-2.8
Medication for pain relief, constipation, heartburn	4.1	7.0	7.5	2.5	2.7
Osteoporosis (self-reported)	4.1	5.0	5.4	-2.3	-2.2
Waist Hip Ratio (WHR)	3.9	17.7	18.7	-4.3	-4.1
Supplements: Fish oil (including cod liver oil)	3.9	5.0	6.4	-2.5	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	5.1	-2.0	-2.2
Time employed in main current job	3.5	4.1	4.5	1.9	2.1
Blood Red Count	3.2	30.5	35.1	-5.1	-5.9
Medication: Paracetamol	3.0	4.9	4.9	-2.2	-2.2
Comparative height size at age 10	3.0	16.6	19.1	-3.7	-4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	6.8	-2.4	-2.6
Ever highly irritable/argumentative for 2 days	2.9	3.4	4.5	1.5	2.1
Serious illness, injury or assault to yourself	2.8	3.4	4.2	-1.6	-2.0
Pain all over the body in last month	2.8	3.0	5.0	-1.0	-2.2
Hair/balding pattern: Pattern 4	2.8	6.7	7.2	2.5	2.7
Pain experienced in last month	2.8	4.6	5.4	2.0	2.3
Intelligence (Savage-Jansen 2018)	2.6	7.9	9.2	-3.0	-2.6
Osteoarthritis (self-reported)	2.5	3.3	3.4	-1.8	-1.9
Pain type(s) experienced in last month: Hip pain	2.4	3.1	4.3	-1.4	-2.1
Headache pain in last month	2.3	3.9	4.6	-2.1	-1.8
Mineral and other dietary supplements	2.3	3.1	3.2	1.8	1.8
Rheumatoid Arthritis	2.1	3.0	3.3	1.6	1.8
Standing height	2.1	20.6	22.1	-4.7	-4.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	3.8	-1.6	-1.9
Worry too long after embarrassment	2.1	3.4	4.0	1.7	2.0
Qualifications: College or University degree	2.1	6.7	9.4	-3.1	-2.0
Chest pain or discomfort	2.1	3.0	3.3	-1.8	-1.7
Knee pain experienced in last month	2.1	3.2	3.2	1.8	1.8
Height	2.0	38.0	44.0	-6.6	-5.7
Chronic bronchitis/emphysema (father)	2.0	2.4	2.4	-1.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.6	-1.9	-1.0
Migraine (self-reported)	1.9	2.4	2.5	-1.6	-1.5
Medication: Ibuprofen	1.9	2.3	2.5	-1.6	-1.4
Number of self-reported non-cancer illnesses	1.9	3.3	3.4	-1.9	-1.8
Medication: Paracetamol	1.9	2.9	3.4	-1.6	-1.8
Qualifications: A levels/AS levels or equivalent	1.7	3.7	4.2	-2.0	-1.8
Family relationship satisfaction	1.7	2.1	2.5	1.6	1.3
Medication for cholesterol	1.7	2.6	2.9	1.5	1.7
Average weekly champagne plus white wine intake	1.7	2.3	2.6	-1.6	-1.4
Bipolar Disorder (2011)	1.6	1.6	1.9	1.4	1.1
Father’s age at death	1.6	2.2	3.6	-1.9	-0.9
Happiness	1.6	1.9	2.5	1.6	1.2
Heart disease (mother)	1.6	1.9	2.8	1.0	1.7
Ever smoked	1.6	2.8	3.0	-1.7	-1.7
Medication: Co-codamol	1.5	1.8	1.8	-1.3	-1.4
Relative age voice broke	1.5	2.3	2.3	-1.5	-1.5
Alzheimer’s Disease (in father)	1.4	1.5	2.4	0.8	1.5
Peak expiratory flow (PEF)	1.4	3.3	4.5	-1.4	-2.1
Gout (self-reported)	1.4	2.0	2.2	1.5	1.3
Medication: Omeprazole	1.4	1.7	1.9	-1.2	-1.4
Fractured/broken bones in last 5 years	1.4	1.8	2.0	-1.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	1.8	-1.2	-1.3
Past tobacco smoking	1.3	2.3	2.7	1.6	1.4
Illnesses of mother	1.3	1.6	2.6	-0.7	-1.6
Number of full brothers	1.3	1.6	2.1	-1.1	-1.4
Average weekly red wine intake	1.3	1.9	2.1	-1.4	-1.3
Medication: Atorvastatin	1.3	1.7	1.8	1.4	1.2
Supplements: Calcium	1.3	1.5	1.6	-1.2	-1.3
Supplements: Zinc	1.2	1.3	1.8	-1.3	-0.9
Smoking status: Previous	1.2	1.8	1.9	-1.4	-1.3
Smoking Status	1.1	2.7	3.4	-1.8	-1.4
Average weekly spirits intake	1.1	1.3	2.1	1.4	0.8
Alcohol usually taken with meals	1.1	1.8	1.9	-1.4	-1.3
Allergy	1.1	2.5	3.5	-1.2	-1.9
Neuroticism score	1.1	2.3	3.2	1.8	1.2
Trunk predicted mass	1.1	6.2	6.5	-2.4	-2.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	1.8	-1.3	-1.3
Alcohol intake frequency.	1.1	2.6	3.3	1.8	1.4
Supplements: Vitamin C	1.1	1.3	1.3	-1.2	-1.1
Basal cell carcinoma (self-reported)	1.1	1.3	1.8	-0.9	-1.3
Reaction Time	1.0	2.0	2.0	1.4	1.4
Systolic blood pressure, automated reading	1.0	2.8	3.5	1.9	1.5
Medication: Metformin	1.0	1.4	1.8	-1.0	-1.3
Age when periods started (menarche)	1.0	2.4	3.6	1.1	1.9
Trunk fat-free mass	1.0	5.9	6.2	-2.4	-2.5
Birth weight	1.0	2.2	2.5	-1.4	-1.6
Mean time to correctly identify matches	1.0	1.9	2.0	1.3	1.4
Mother’s age at death	1.0	1.3	1.7	0.9	1.3
Age started oral contraceptive pill	1.0	1.2	2.0	0.7	1.4
Crohns Disease (2017)	0.9	2.1	2.3	-1.4	-1.5
Blood Eosinophil Count	0.9	6.6	8.7	2.1	2.9
Cardiovascular Disease	0.9	2.9	4.2	-1.2	-2.1
Angina	0.9	1.2	2.0	1.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.1	-0.8	-1.4
Loud music exposure frequency	0.9	1.0	1.3	0.8	1.1
Number of children fathered	0.9	1.0	1.1	-1.0	-1.0
Angina (self-reported)	0.9	1.2	2.0	1.4	0.6
Age at last live birth	0.9	1.3	1.5	-1.0	-1.2
Pack years of smoking	0.9	1.3	2.4	0.4	1.6
Depressed Affect (Nagel 2018)	0.8	1.6	2.8	-0.7	-1.7
Worry (Nagel 2018)	0.8	1.8	2.1	1.5	1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.5	-1.6	-1.1
Relative age of first facial hair	0.8	1.6	1.8	-1.3	-1.2
Noisy workplace	0.8	1.0	1.1	-1.0	-1.0
Pulse wave Arterial Stiffness index	0.8	0.9	1.1	1.1	0.8
Medication: Amlodipine	0.8	1.1	1.5	1.2	0.8
Pulse wave peak to peak time	0.8	0.9	1.1	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	1.9	-1.2	-1.4
Asthma (self-reported)	0.8	1.6	2.2	0.9	1.5
Medication: Gliclazide	0.8	0.9	1.3	0.7	1.1
Medication: Bendroflumethiazide	0.8	1.2	1.6	1.3	0.9
Primary Biliary Cirrhosis	0.7	1.0	1.2	1.1	0.9
Ulcerative Colitis	0.7	1.0	1.4	1.2	0.8
Hearing difficulty/problems: Yes	0.7	1.0	1.4	-0.8	-1.2
Diabetes (mother)	0.7	0.9	1.5	-0.5	-1.2
Nervous feelings	0.7	1.4	1.4	1.2	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	1.6	1.3	0.9
Shortness of breath walking on level ground	0.7	0.8	1.0	1.0	0.8
Whole body fat-free mass	0.7	4.1	4.4	-2.0	-2.1
Whole body water mass	0.7	4.1	4.3	-2.0	-2.1
Risk taking	0.7	1.0	1.7	-1.3	-0.6
Arm predicted mass (left)	0.7	3.3	3.4	-1.8	-1.8
Ulcerative Colitis (UC)	0.6	1.1	1.8	1.3	0.7
Ovarian Cancer	0.6	0.8	0.9	-1.0	-0.8
Fasting Glucose	0.6	0.7	0.7	0.8	0.8
Lung FEV1/FVC ratio	0.6	3.2	5.6	2.4	0.8
Leg fat-free mass (left)	0.6	3.0	3.1	-1.7	-1.8
Leg predicted mass (left)	0.6	3.3	3.3	-1.8	-1.8
Financial difficulties in last 2 years	0.6	0.8	1.2	-0.6	-1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	0.9	0.9	1.0
Fluid intelligence score	0.6	1.3	1.8	-1.3	-0.9
Asthma	0.6	1.3	2.0	0.7	1.4
Medication: Cholesterol lowering	0.6	0.9	1.1	1.1	0.9
Breastfed as a baby	0.6	0.8	1.0	0.8	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.8	0.9	0.8
Illnesses of father: Heart disease	0.6	0.8	0.9	-0.9	-0.9
Eye problems/disorders: Cataract	0.6	0.7	1.0	1.0	0.7
Basal metabolic rate	0.6	3.3	3.4	-1.8	-1.9
Arm fat-free mass (left)	0.6	2.9	2.9	-1.7	-1.7
Unable to work because of sickness or disability	0.6	0.8	1.4	-0.4	-1.2
Commuting to job workplace: Cycle	0.6	0.7	0.9	0.7	0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	0.5	1.1
Crohns Disease (2012)	0.5	0.8	1.0	-0.8	-1.0
Lupus	0.5	0.7	1.1	1.0	0.6
Triglycerides	0.5	0.8	1.3	0.6	1.2
Systolic Blood Pressure	0.5	2.6	2.8	1.7	1.5
Chronotype (morning person)	0.5	1.3	2.3	-1.5	-0.4
Sensitivity / hurt feelings	0.5	0.9	1.0	1.0	0.9
Diabetes (father)	0.5	0.6	0.9	-0.9	-0.6
Severe depression (siblings)	0.5	0.6	0.7	-0.7	-0.8
High blood pressure (mother)	0.5	0.7	1.4	0.1	1.2
Medication: Simvastatin	0.5	0.8	1.4	1.2	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.7	0.8	0.6
Overall health rating	0.5	1.1	2.2	-0.1	-1.5
Alcohol drinker status: Never	0.5	0.5	0.8	0.5	0.9
Irritability	0.5	0.9	1.0	-0.9	-1.0
Ever depressed for a whole week	0.5	0.6	0.7	-0.8	-0.7
Alcohol drinker status: Previous	0.5	0.6	1.0	1.0	0.4
Neuroticism (2016)	0.4	0.6	0.7	0.6	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.9	0.3
Neuroticism	0.4	1.0	1.5	1.2	0.7
Impedance of leg (right)	0.4	1.7	2.2	-1.5	-1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.8	0.9	0.4
High blood pressure	0.4	1.0	1.7	-0.5	-1.3
Waist circumference	0.4	1.5	1.6	-1.2	-1.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.9	-0.3
Qualifications: None of the above	0.4	0.8	1.3	1.1	0.5
Impedance of arm (right)	0.4	1.7	1.8	-1.3	-1.2
Alcohol intake versus 10 years previously	0.4	0.7	1.3	-1.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.6	0.6	0.8
Arm fat-free mass (right)	0.4	1.8	1.9	-1.4	-1.3
Wheeze or whistling in the chest in last year	0.4	0.7	1.0	-1.0	-0.6
Medication: Aspirin	0.4	0.6	0.8	-0.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.6	0.8	0.5
Leg fat-free mass (right)	0.4	1.9	2.0	-1.4	-1.4
Loneliness, isolation	0.4	0.6	1.1	-0.2	-1.1
Commuting to job workplace: Walk	0.4	0.4	0.5	-0.7	0.6
Leg predicted mass (right)	0.4	2.0	2.0	-1.4	-1.4
Guilty feelings	0.4	0.6	0.9	1.0	0.6
Hearing aid user	0.4	0.5	0.5	-0.7	-0.7
Financial situation satisfaction	0.4	0.5	0.7	0.6	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	-0.3
Breast Cancer	0.3	0.8	1.6	-1.3	-0.2
Prostate Cancer	0.3	0.5	0.7	-0.5	-0.8
Mean Putamen Volume	0.3	0.3	0.5	-0.4	-0.7
Respiratory disease	0.3	0.7	1.1	0.6	1.0
Pack years adult smoking proportion	0.3	0.4	0.8	-0.1	0.9
Current tobacco smoking	0.3	0.5	0.6	-0.6	-0.8
Average weekly fortified wine intake	0.3	0.4	0.7	0.1	0.9
Maternal smoking around birth	0.3	0.4	0.5	-0.5	-0.7
Fed-up feelings	0.3	0.5	0.9	-0.1	-1.0
Trunk fat mass	0.3	1.3	1.7	-1.3	-1.0
Hearing difficulty/problems with background noise	0.3	0.4	0.9	0.2	-0.9
Mouth/teeth dental problems	0.3	0.4	0.7	-0.9	-0.2
Weight	0.3	1.4	1.4	-1.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.3	-0.6	-0.6
Lung cancer (father)	0.3	0.3	0.4	0.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	-0.9	-0.6
Health satisfaction	0.3	0.4	0.6	-0.8	-0.5
Eye problems/disorders: None of the above	0.3	0.3	0.4	-0.6	-0.4
Medication: Blood pressure	0.3	0.6	0.7	0.8	0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.3	0.8
Arm predicted mass (right)	0.3	1.8	1.8	-1.4	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	-0.7	-0.4
Qualifications: nursing, teaching	0.3	0.5	0.8	-0.9	-0.5
Smoking status: Current	0.3	0.5	0.5	-0.7	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.4	0.6	1.2
Schizophrenia (2018)	0.2	0.4	0.4	-0.6	-0.6
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	-0.7	-0.2
Blood White Count	0.2	1.4	1.6	1.2	1.1
Allergy or Eczema	0.2	0.5	0.8	0.4	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.4	0.6	0.5
Tanning	0.2	2.1	3.3	-1.8	-0.9
Number of treatments/medications taken	0.2	0.4	0.6	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.5	0.4	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.4	0.8
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.7	-0.3
Medication: Atenolol	0.2	0.3	0.6	-0.0	0.8
Body mass index (BMI)	0.2	0.8	0.9	0.9	0.9
Heart attack	0.2	0.3	0.6	-0.7	-0.1
Illnesses of siblings	0.2	0.2	0.3	-0.5	-0.5
Falls in the last year	0.2	0.3	0.6	0.8	0.3
Number of live births	0.2	0.2	0.4	-0.1	-0.7
Medication: Lansoprazole	0.2	0.2	0.3	0.6	0.0
Prospective memory result	0.2	0.2	0.2	0.5	0.5
Impedance of arm (left)	0.2	0.8	0.9	-0.9	-0.8
Birth weight of first child	0.2	0.4	0.8	-0.1	-0.9
Pulse wave reflection index	0.2	0.3	0.3	0.5	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.3	-0.7
Medication: Allopurinol	0.2	0.3	0.4	0.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.6	-0.0
Whole body fat mass	0.2	0.7	0.9	-0.9	-0.8
Leg pain on walking	0.2	0.3	0.5	0.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.2	0.6
Medication: Aspirin	0.2	0.3	0.4	-0.4	-0.6
Miserableness	0.2	0.4	0.8	0.9	-0.1
Wears glasses or contact lenses	0.2	0.2	0.2	-0.5	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.3	-0.6
Leg fat percentage (left)	0.2	0.8	0.9	0.8	1.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	-0.4	-0.5
Cholesterol lowering medication	0.2	0.4	0.6	0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.8	-0.1
Impedance of whole body	0.2	0.9	1.2	-1.1	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.4	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.5	0.3
Major Depression (MDD)	0.1	0.1	0.1	0.3	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.4	-0.1
HbA1C	0.1	0.1	0.2	0.4	-0.0
Schizophrenia (2014)	0.1	0.1	0.2	0.1	-0.5
Blood Platelet Count	0.1	1.3	1.5	1.1	1.2
Heel T-Score	0.1	0.6	0.9	0.6	0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.5	0.1
Trunk fat percentage	0.1	0.3	0.5	-0.7	-0.3
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	0.3
Taking other prescription medications	0.1	0.1	0.1	-0.3	-0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.2	-0.3	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.5	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.6	-0.1
Impedance of leg (left)	0.1	0.3	0.5	-0.7	-0.3
Had menopause	0.1	0.2	0.3	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.3	0.5
Hip circumference	0.1	0.5	0.5	0.7	0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	0.0
Pulse rate	0.1	0.1	0.2	-0.3	-0.4
Depression (self-reported)	0.1	0.1	0.2	-0.5	0.1
Arm fat mass (right)	0.1	0.3	0.3	-0.5	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.5	0.1
Glaucoma (self-reported)	0.1	0.1	0.2	-0.5	-0.0
Comparative body size at age 10	0.1	0.3	0.4	0.4	0.7
Age at first live birth	0.1	0.1	0.3	-0.5	0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.6	-0.2
Leg fat mass (right)	0.1	0.3	0.4	-0.6	-0.5
Pulse rate, automated reading	0.1	0.4	0.8	-0.1	-0.9
Suffer from ‘nerves’	0.1	0.1	0.1	0.2	-0.3
Had major operations	0.1	0.2	0.3	0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.2	0.3
Hypertension (Self-reported)	0.1	0.3	0.6	0.1	-0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	0.2
Arm fat percentage (left)	0.1	0.2	0.2	0.5	0.5
Mood swings	0.1	0.1	0.3	0.5	-0.2
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.1	-0.5
Breast cancer (self-reported)	0.1	0.1	0.1	0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.3	-0.5	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.0	0.4
Medication: Blood pressure	0.1	0.2	0.3	-0.4	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.3	0.5	0.2
Medication: Lisinopril	0.1	0.1	0.1	-0.1	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.2	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.4	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	0.6	0.8	0.5
Bipolar Disorder (2018)	0.0	0.0	0.0	0.1	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1
Age at First Birth	0.0	0.1	0.1	0.3	-0.1
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.1	0.1
BMI	0.0	0.2	0.2	0.5	0.4
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.4	-0.1
Hair Pigment	0.0	0.2	0.4	-0.0	0.6
Hand grip strength (left)	0.0	0.1	0.1	0.3	0.2
Hand grip strength (right)	0.0	0.0	0.1	-0.1	-0.3
Had other major operations	0.0	0.0	0.0	0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.0	0.1
Diabetes (self-reported)	0.0	0.1	0.1	0.1	-0.3
Medication: Ramipril	0.0	0.0	0.0	0.2	-0.0
Arm fat percentage (right)	0.0	0.0	0.1	0.3	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.0	-0.0
Tense / ‘highly strung’	0.0	0.0	0.1	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.4	0.0
High blood pressure (siblings)	0.0	0.0	0.1	-0.2	-0.1
Body fat percentage	0.0	0.0	0.1	-0.3	-0.1
Leg fat percentage (right)	0.0	0.1	0.2	0.3	0.4
Exposure to tobacco smoke outside home	0.0	0.0	0.0	0.1	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.1	-0.1
Number of full sisters	0.0	0.0	0.0	0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.1	0.1	0.3	0.0
Friendships satisfaction	0.0	0.0	0.0	-0.0	0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	-0.1
Arm fat mass (left)	0.0	0.1	0.1	-0.3	-0.3
Number of operations (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Myopia	0.0	0.0	0.0	0.2	0.1
Leg fat mass (left)	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

SLC25A21

Models

Trait associations