Hub : Genes

SLC25A40

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.0630 0.0280 0.0054 0.091 NA 0.053 NA 0.066 1.1e-05 NA 0.0007 NA 0.00016
2 GTEx Ovary 0.1630 0.0740 0.0087 -0.012 NA -0.012 NA -0.012 9.8e-01 NA 0.9200 NA 0.94000
3 METSIM Adipose 0.0315 0.0176 0.0170 -0.001 0.004 0.001 0.002 0.000 4.0e-01 0.078 0.2400 0.13 0.34000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.9 4.6 6.1 -1.7 -2.3 -2.5
Bipolar Disorder or Schizophrenia 3.7 9.1 19.4 -2.0 -2.0 -4.4
Depressed Affect (Nagel 2018) 0.0 0.1 0.1 -0.4 -0.3 -0.2
Depression (Nagel 2018) 0.4 0.6 1.1 0.7 1.1 -0.6
Intelligence (Savage-Jansen 2018) 0.7 2.2 2.9 1.7 1.5 1.2
Neuroticism (Nagel 2018) 0.2 0.5 0.7 -0.7 -0.5 -0.8
Schizophrenia (2018) 2.5 5.2 13.5 -1.2 -0.8 -3.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.5 -0.8 0.1
Worry (Nagel 2018) 0.6 1.3 2.2 -1.5 -1.2 -0.6
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 0.1 0.0 0.3
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.3 0.0 0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 -0.2 -0.1 0.6
Crohns Disease (2017) 0.5 1.1 1.4 -1.0 -1.2 -0.9
Irritable Bowel Disease (IBD) 0.8 2.0 3.5 -1.5 -1.9 0.4
Ulcerative Colitis (UC) 0.7 1.3 2.1 -0.9 -1.4 0.9
Major Depression (MDD) 0.5 0.6 1.1 1.1 0.8 0.3
Reaction Time 0.5 0.9 2.7 0.1 0.3 -1.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.5 1.6 1.1 -0.0
Breast Cancer 0.4 0.9 1.6 -1.0 -1.3 0.4
Ovarian Cancer 1.7 2.3 6.1 0.8 0.4 2.5
Prostate Cancer 0.1 0.2 0.4 0.2 0.3 -0.6
Age at First Birth 0.2 0.3 0.7 0.5 0.8 0.2
Bipolar Disorder (2011) 4.3 4.1 7.1 -1.6 -1.6 -2.7
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 -0.8 -0.4 0.4
Coronary Artery Disease (CAD) 0.7 0.9 2.0 0.7 0.4 1.4
Crohns Disease (2012) 0.8 1.2 1.9 -1.4 -1.3 -0.1
Mean Putamen Volume 0.1 0.2 0.2 0.3 0.5 -0.4
Fasting Glucose 0.1 0.2 0.3 0.1 0.6 -0.4
HbA1C 0.7 0.8 2.0 -0.6 -0.2 1.4
HDL Cholesterol 0.2 0.3 0.6 0.8 0.3 -0.4
LDL Cholesterol 0.3 0.5 0.6 -0.7 -0.7 0.7
Lupus 0.2 0.3 0.9 -0.3 -0.2 1.0
Neuroticism (2016) 1.7 2.4 6.6 -0.8 -0.2 -2.6
Primary Biliary Cirrhosis 1.6 2.2 5.7 -0.5 -0.9 -2.4
Rheumatoid Arthritis 0.5 0.7 1.6 1.3 0.4 0.5
Schizophrenia (2014) 2.0 4.4 10.7 -1.1 -1.2 -3.3
Triglycerides 0.6 0.9 2.7 -0.3 0.1 1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.0 0.4 -0.2
Ulcerative Colitis 0.1 0.2 0.4 -0.1 -0.3 0.6
Blood Eosinophil Count 0.4 2.8 6.5 -1.3 -0.5 -2.5
Blood Platelet Count 0.2 2.4 6.7 -0.5 -0.5 2.6
Blood Red Count 0.3 2.7 4.6 -2.1 -1.8 0.6
Blood White Count 2.0 15.0 26.1 -5.1 -4.4 0.1
Heel T-Score 0.1 0.5 1.5 -0.2 -0.3 1.2
BMI 0.0 0.1 0.4 -0.1 0.6 -0.3
Height 0.5 10.4 29.8 -0.1 1.1 -5.5
Waist Hip Ratio (WHR) 1.3 5.8 11.2 -2.5 -3.3 -0.0
Systolic Blood Pressure 0.2 1.1 3.2 -0.4 -1.8 0.1
Smoking Status 0.4 0.9 2.3 -0.3 -0.4 -1.5
Allergy or Eczema 0.1 0.3 0.7 0.4 -0.8 0.2
Cardiovascular Disease 1.4 4.6 6.4 -1.9 -2.5 1.9
Hypothyroidism (self reported) 0.1 0.3 0.5 -0.7 -0.2 -0.6
Respiratory disease 0.3 0.6 1.4 -0.5 -1.2 0.2
Type 2 Diabetes (T2D) (2018) 1.1 2.1 3.2 1.5 0.8 -1.8
Lung FEV1/FVC ratio 0.1 0.7 1.2 -1.0 -0.3 -1.1
Lung FVC 0.0 0.2 0.6 0.8 -0.2 0.3
Neuroticism 1.7 4.1 4.5 -2.1 -1.8 -2.1
Chronotype (morning person) 0.1 0.2 0.4 0.1 0.3 0.7
Hair Pigment 0.0 1.4 4.1 0.3 0.2 2.0
Tanning 0.1 0.9 1.4 -0.9 -1.2 -0.7
Hand grip strength (left) 1.5 3.9 6.7 2.1 2.6 -1.0
Number of treatments/medications taken 0.6 1.1 2.8 -0.1 -0.8 1.7
Average weekly spirits intake 0.9 1.2 3.0 0.4 -0.6 1.7
Sensitivity / hurt feelings 0.5 0.8 2.3 0.0 0.5 -1.5
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 -0.5 0.1 -0.8
Hearing difficulty/problems: Yes 0.3 0.5 0.9 -0.6 -0.3 -0.9
Relative age of first facial hair 0.6 1.3 3.6 0.3 -0.3 1.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.4 0.2 0.1 1.6
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.2 -1.8 -1.6 -0.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.8 0.3 -0.1
Systolic blood pressure, automated reading 0.4 1.3 2.0 -0.5 -1.4 -1.3
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 5.2 2.3 1.4 1.5
Angina 0.2 0.3 0.4 -0.5 -0.3 0.6
Medication for hormone replacement therapy 2.4 2.7 4.2 -1.8 -2.0 0.8
Vitamin and mineral supplements 0.3 0.5 1.0 -1.0 -0.6 -0.0
Supplements: Zinc 1.7 1.9 3.2 1.5 1.8 -0.5
Medication: Co-codamol 0.1 0.1 0.1 0.2 -0.3 -0.3
Medication: Metformin 1.9 2.7 4.3 2.1 1.6 -1.2
Diabetes (father) 1.1 1.3 1.6 -1.0 -1.2 1.3
Diabetes (mother) 2.1 2.6 4.0 -1.8 -2.0 0.8
Severe depression (siblings) 1.9 2.1 5.9 -0.6 0.1 -2.4
Pack years adult smoking proportion 0.1 0.2 0.4 -0.6 -0.3 -0.1
Impedance of leg (right) 0.6 3.1 5.7 -1.1 -2.4 1.6
Leg fat-free mass (left) 0.5 2.8 3.9 1.1 1.9 -2.0
Trunk fat percentage 0.3 1.0 1.3 -0.8 -1.0 -1.1
Hand grip strength (right) 1.8 4.8 7.5 2.5 2.7 -0.8
Townsend deprivation index at recruitment 1.7 2.4 2.9 -1.7 -1.6 -1.3
Current tobacco smoking 0.1 0.2 0.5 -0.1 0.2 -0.7
Average weekly fortified wine intake 0.5 0.6 0.8 -0.9 -0.9 0.7
Maternal smoking around birth 0.0 0.1 0.1 0.1 -0.3 -0.3
Fed-up feelings 0.3 0.5 1.4 0.1 0.4 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 0.2 0.5 -1.0
Relative age voice broke 1.0 1.5 3.6 0.7 0.5 1.9
Taking other prescription medications 1.0 1.6 2.8 -1.2 -1.7 0.8
Age when periods started (menarche) 0.2 0.6 1.3 -0.6 -1.1 0.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.4 0.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 2.4 1.6 1.4 0.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.6 -0.8 -0.4 -0.0
Qualifications: CSEs or equivalent 0.5 0.6 1.1 1.0 0.9 0.2
Serious illness, injury or assault to yourself 0.2 0.3 0.7 -0.1 -0.9 0.3
High blood pressure 1.3 3.6 5.6 -1.8 -2.4 1.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.7 -0.2 -1.3 -0.0
Multivitamins +/- minerals 0.6 0.8 1.7 1.3 0.7 0.5
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.5 0.3 -0.7
Supplements: Glucosamine 0.7 0.9 1.7 1.3 1.0 -0.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 -0.8 -0.6 0.1
Medication: Atenolol 2.0 2.5 3.6 -1.9 -1.7 0.9
Medication: Levothyroxine sodium 1.1 1.8 2.8 -1.7 -1.4 0.8
Sitting height 0.4 3.1 8.7 0.4 0.7 -3.0
Chronic bronchitis/emphysema (father) 0.6 0.7 1.2 -1.1 -0.9 -0.3
High blood pressure (mother) 0.6 0.8 2.0 0.6 0.3 1.4
Body mass index (BMI) 0.0 0.1 0.1 0.2 0.4 -0.3
Impedance of leg (left) 0.7 3.3 5.6 -1.2 -2.4 1.7
Leg predicted mass (left) 0.5 2.9 4.1 1.0 1.8 -2.0
Trunk fat mass 0.2 0.8 1.9 -0.5 -0.5 -1.4
Waist circumference 0.1 0.5 0.8 -0.4 -0.7 -0.9
Number of incorrect matches in round 1.2 2.0 5.0 -0.9 -0.5 -2.2
Past tobacco smoking 0.4 0.8 1.5 0.7 1.2 0.7
Alcohol usually taken with meals 0.6 0.9 1.4 -1.2 -1.1 0.3
Nervous feelings 0.5 1.0 1.9 -1.0 -0.2 -1.4
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 3.7 -1.5 -0.7 -1.9
Hearing difficulty/problems with background noise 0.6 1.0 2.7 -0.1 0.7 -1.6
Hair/balding pattern: Pattern 2 0.5 0.7 0.7 -0.9 -0.7 -0.9
Had menopause 0.7 0.9 1.6 -0.6 -0.8 -1.3
Had other major operations 0.6 0.8 1.1 -1.0 -0.8 0.7
Forced vital capacity (FVC) 0.2 0.8 2.1 1.4 0.4 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 0.8 0.9 0.9 0.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.2 -0.9 0.0 -1.1
Qualifications: None of the above 0.8 1.7 3.3 -1.8 -1.3 -0.4
Financial difficulties in last 2 years 0.1 0.2 0.3 -0.3 -0.4 0.6
Mouth/teeth dental problems 0.8 1.2 2.2 0.8 0.9 1.5
Heart attack 0.5 0.7 1.9 0.1 -0.3 1.4
Allergy 0.5 1.1 2.7 0.8 1.6 0.3
Pain all over the body in last month 0.0 0.0 0.1 0.1 -0.0 -0.2
Diabetes (self-reported) 0.6 0.9 1.4 1.2 0.5 -1.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.4 -0.5 -1.2 -0.1
Medication: Ramipril 0.9 1.1 2.7 -0.4 -0.7 -1.6
Medication: Simvastatin 0.4 0.6 1.5 -0.5 -1.2 0.3
Fluid intelligence score 1.3 2.8 4.4 2.1 1.5 1.3
Illnesses of siblings 0.1 0.2 0.3 0.3 0.5 -0.5
Neuroticism score 1.2 2.5 2.9 -1.7 -1.4 -1.7
Weight 0.2 0.9 1.9 0.4 0.7 -1.4
Impedance of arm (right) 0.7 3.1 6.0 -1.7 -2.5 0.7
Arm fat percentage (right) 0.1 0.3 0.3 -0.5 -0.6 -0.5
Trunk fat-free mass 0.6 3.7 5.3 1.5 2.3 -1.9
Hip circumference 0.3 1.4 3.5 0.6 0.6 -1.9
Time employed in main current job 0.6 0.6 1.8 0.2 -0.3 1.3
Alcohol intake versus 10 years previously 1.2 1.8 3.0 0.9 1.3 -1.7
Father’s age at death 0.3 0.4 1.1 0.3 0.4 1.0
Worrier / anxious feelings 0.9 1.7 2.5 -1.6 -1.4 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.1 -1.1 -1.0 0.3
Falls in the last year 3.3 4.5 7.4 -2.4 -2.7 -0.1
Hair/balding pattern: Pattern 3 1.0 1.5 2.9 1.7 1.2 0.3
Number of live births 0.4 0.5 1.1 -0.5 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.4 1.2 0.3 -0.3
Pulse rate 0.4 0.7 0.9 -0.9 -0.9 0.7
Happiness 0.5 0.6 1.7 -0.1 0.2 -1.3
Noisy workplace 1.1 1.4 1.7 -1.3 -1.1 -1.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.4 0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.7 3.7 1.9 1.8 1.1
Mouth/teeth dental problems: Dentures 0.6 1.0 2.2 -0.8 -1.5 0.3
Asthma 0.8 1.6 2.5 -1.1 -1.6 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 0.0 -0.0 0.1
Medication: Cholesterol lowering 0.3 0.5 0.7 -0.7 -0.9 0.6
Depression (self-reported) 1.2 1.4 1.7 -1.3 -1.1 1.2
Medication: Lansoprazole 1.0 1.1 1.9 0.9 0.8 1.4
Prospective memory result 2.6 3.2 4.8 -2.2 -2.1 -0.6
Lung cancer (father) 0.3 0.3 0.6 0.7 0.5 0.4
Illnesses of mother 0.1 0.1 0.1 0.3 0.4 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.3 1.1 0.4 0.1
Pulse wave Arterial Stiffness index 1.4 1.6 3.0 -1.7 -1.3 -0.3
Impedance of arm (left) 0.5 2.2 4.6 -1.2 -2.1 0.6
Arm fat mass (right) 0.1 0.3 0.8 0.0 0.0 -0.9
Trunk predicted mass 0.6 3.4 5.0 1.4 2.2 -1.8
Standing height 0.2 2.4 6.1 0.6 0.9 -2.5
Length of working week for main job 0.1 0.1 0.3 -0.1 0.3 0.6
Exposure to tobacco smoke at home 0.3 0.3 0.8 -0.9 -0.3 0.4
Breastfed as a baby 1.3 1.6 2.1 1.4 1.2 1.1
Tense / ‘highly strung’ 1.2 2.0 3.1 -1.8 -1.6 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.7 5.1 -2.3 -1.6 -0.5
Hair/balding pattern: Pattern 4 0.2 0.4 0.9 -0.4 -0.4 0.9
Birth weight of first child 0.3 0.6 1.4 -0.6 -0.1 -1.2
Peak expiratory flow (PEF) 0.2 0.4 1.1 1.1 0.4 -0.3
Pulse wave reflection index 0.3 0.3 1.0 0.1 -0.1 1.0
Ever highly irritable/argumentative for 2 days 2.4 2.9 5.3 1.8 2.3 -0.3
Loud music exposure frequency 0.4 0.5 1.0 0.2 1.0 -0.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 -0.5 -0.3 0.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.4 -0.3 -0.2 -1.6
Blood clot in the leg (DVT) 0.7 0.9 1.5 0.6 0.9 -1.2
Medication: Paracetamol 1.1 1.8 3.4 1.3 0.5 1.8
Headache pain in last month 3.2 5.5 9.6 -3.1 -2.6 0.3
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 5.6 2.2 2.4 -0.3
Glaucoma (self-reported) 1.0 1.2 2.0 -1.0 -1.4 0.6
Gout (self-reported) 0.5 0.6 1.8 -0.3 -0.2 1.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 -0.8 -0.4 0.2
Medication: Amlodipine 0.1 0.1 0.1 0.3 -0.3 0.4
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.2 0.5 -0.3 1.5
Birth weight 0.0 0.1 0.1 0.1 -0.3 0.3
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.0 -1.4 -0.2 -1.0
High blood pressure (siblings) 0.2 0.3 0.8 0.3 0.1 0.9
Forced vital capacity (FVC), Best measure 0.1 0.5 1.4 1.2 0.2 -0.2
Body fat percentage 0.2 0.7 1.0 -0.7 -1.0 -0.8
Leg fat percentage (right) 0.1 0.4 0.7 -0.6 -0.9 -0.2
Arm fat-free mass (right) 0.6 3.0 3.9 1.4 2.0 -1.8
Exposure to tobacco smoke outside home 0.5 0.6 1.1 -1.1 -0.3 0.8
Comparative body size at age 10 0.1 0.4 0.9 0.4 0.9 0.4
Number of full brothers 0.6 0.8 1.2 0.9 1.1 -0.6
Worry too long after embarrassment 0.3 0.5 1.0 -0.3 -0.7 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 3.7 -1.3 -0.5 -1.9
Wheeze or whistling in the chest in last year 0.4 0.8 1.1 -0.8 -0.8 -1.0
Number of children fathered 2.2 2.5 4.3 1.8 2.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.0 0.7 1.0 -0.7
Age at first live birth 0.5 0.8 1.5 0.9 1.2 -0.2
Pulse wave peak to peak time 1.3 1.6 2.9 1.7 1.4 0.2
Health satisfaction 0.1 0.1 0.2 0.3 0.1 0.5
Shortness of breath walking on level ground 2.4 2.9 4.8 -1.9 -2.2 -0.6
Qualifications: College or University degree 0.5 1.6 2.5 -1.2 -1.0 -1.6
Eye problems/disorders: None of the above 0.3 0.3 0.6 -0.6 0.1 -0.8
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.3 -1.1 -0.8 0.1
Emphysema/chronic bronchitis 1.7 1.9 3.2 -1.8 -1.4 -0.7
Medication for pain relief, constipation, heartburn 0.5 0.9 2.2 -0.7 0.0 -1.5
Neck or shoulder pain in last month 1.1 1.5 2.4 -1.2 -1.6 0.8
Medication: Blood pressure 0.8 1.4 2.6 -1.3 -1.6 -0.2
Angina (self-reported) 0.1 0.1 0.1 -0.3 -0.1 0.3
Migraine (self-reported) 1.6 2.0 3.2 -1.2 -1.2 1.8
Medication: Ibuprofen 0.0 0.0 0.1 -0.0 0.2 0.0
Medication: Allopurinol 0.7 0.9 1.0 -0.9 -0.9 1.0
Medication: Omeprazole 1.3 1.5 3.8 -0.2 -0.8 2.0
Medication: Seretide 50 evohaler 1.1 1.3 2.3 -1.1 -1.5 0.6
Mean time to correctly identify matches 0.5 0.9 2.5 0.0 0.4 -1.6
Heart disease (mother) 1.1 1.4 3.4 0.4 0.8 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 2.0 -0.2 -0.5 1.4
Whole body fat mass 0.2 0.7 1.7 -0.4 -0.4 -1.3
Leg fat mass (right) 0.0 0.2 0.5 -0.1 -0.2 -0.7
Arm predicted mass (right) 0.6 2.9 3.5 1.3 1.8 -1.9
Pulse rate, automated reading 1.4 4.7 7.6 -2.5 -2.8 0.7
Alcohol intake frequency. 0.3 0.8 1.8 0.0 0.7 -1.3
Comparative height size at age 10 0.2 1.0 2.0 0.7 0.8 -1.4
Number of full sisters 0.1 0.1 0.2 -0.5 -0.3 0.1
Suffer from ‘nerves’ 0.0 0.0 0.0 -0.2 -0.2 -0.0
Overall health rating 1.4 2.9 5.7 -1.7 -2.4 0.4
Chest pain or discomfort 0.1 0.1 0.2 -0.3 -0.4 0.5
Had major operations 1.3 1.5 2.8 -1.3 -1.7 -0.1
Age at last live birth 0.2 0.2 0.6 -0.2 0.3 -0.7
Family relationship satisfaction 0.2 0.3 0.7 -0.2 0.1 0.8
Leg pain on walking 0.3 0.4 0.7 0.7 0.9 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 2.6 1.4 1.6 0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.4 0.6 0.2 0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 -0.7 -0.3 0.2
Medication: Aspirin 0.1 0.1 0.3 0.6 -0.0 -0.3
Supplements: Vitamin C 0.6 0.7 0.9 0.7 1.0 -0.9
Knee pain experienced in last month 0.2 0.3 0.6 -0.5 -0.1 -0.8
Hypertension (Self-reported) 1.9 5.3 8.6 -2.4 -2.9 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 6.2 -0.2 -0.1 2.5
Illnesses of father: Heart disease 2.2 3.0 5.2 2.3 1.9 0.2
Illnesses of siblings: Diabetes 0.4 0.5 0.7 0.9 0.8 0.1
Smoking status: Previous 1.6 2.4 4.7 -1.5 -2.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 8.3 2.9 1.6 0.6
Whole body fat-free mass 0.6 3.5 4.8 1.3 2.2 -2.0
Leg fat-free mass (right) 0.6 3.1 4.4 1.2 2.1 -1.9
Arm fat percentage (left) 0.1 0.3 0.3 -0.4 -0.5 -0.6
Average weekly red wine intake 1.2 1.8 2.5 -1.5 -1.6 -0.6
Handedness (chirality/laterality): Left-handed 1.2 1.4 1.9 -1.3 -0.7 -1.4
Mood swings 0.3 0.6 0.9 0.9 0.9 -0.5
Loneliness, isolation 0.9 1.2 2.5 0.7 1.6 -0.8
Long-standing illness, disability or infirmity 0.4 0.6 1.5 -0.3 -0.3 1.2
Ever had bowel cancer screening 4.7 5.5 8.5 -2.9 -2.8 -0.4
Diabetes diagnosed by doctor 1.2 1.9 2.6 1.6 1.1 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 2.9 -1.6 -1.7 -1.1
Friendships satisfaction 0.2 0.3 0.6 -0.1 0.5 0.7
Qualifications: nursing, teaching 1.9 3.0 4.4 2.0 2.1 -0.6
Commuting to job workplace: Walk 4.0 4.3 7.4 -2.3 -2.7 -0.0
Eye problems/disorders: Cataract 1.0 1.1 1.9 -0.8 -0.9 1.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.2 0.6 -0.2
Medication for cholesterol 1.3 2.0 3.0 1.0 1.4 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.9 0.6 -0.0 2.0
Back pain experienced in last month 0.5 0.7 2.0 -0.1 0.4 -1.4
Mineral and other dietary supplements 1.8 2.4 3.9 -2.0 -1.6 0.9
Breast cancer (self-reported) 0.2 0.2 0.3 0.4 0.3 -0.6
Asthma (self-reported) 0.8 1.6 2.2 -1.0 -1.5 1.3
Osteoporosis (self-reported) 3.4 4.2 7.0 2.6 2.3 -0.4
Osteoarthritis (self-reported) 0.1 0.2 0.4 -0.0 -0.7 0.1
Medication: Aspirin 0.1 0.2 0.3 0.6 0.2 -0.5
Medication: Gliclazide 0.4 0.5 0.6 0.8 0.8 -0.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.1 0.2 0.7
Smoking status: Current 0.2 0.3 0.4 0.4 0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.7 1.3 0.6 0.3
Whole body water mass 0.6 3.5 4.8 1.3 2.2 -2.0
Leg predicted mass (right) 0.7 3.5 5.0 1.3 2.2 -1.9
Arm fat mass (left) 0.1 0.2 0.7 0.0 0.1 -0.9
Number of self-reported non-cancer illnesses 3.4 5.9 7.7 -2.5 -2.8 2.0
Average weekly champagne plus white wine intake 0.3 0.4 0.8 0.5 0.4 0.9
Miserableness 0.1 0.2 0.4 -0.1 -0.4 0.7
Guilty feelings 1.2 1.9 2.3 -1.5 -1.4 -1.1
Wears glasses or contact lenses 0.1 0.1 0.2 0.1 0.4 -0.3
Ever taken oral contraceptive pill 1.2 1.4 3.6 1.9 0.6 0.4
Hearing aid user 0.9 1.0 1.5 -0.5 -1.1 1.2
Mother’s age at death 0.6 0.8 1.4 1.2 1.0 -0.1
Financial situation satisfaction 1.0 1.2 2.5 1.0 1.6 0.4
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.3 -0.3 -0.4 1.5
Commuting to job workplace: Public transport 0.3 0.4 0.5 0.5 0.7 -0.6
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -0.5 -1.0 0.5
Medication: Blood pressure 1.0 1.9 2.7 -0.8 -1.5 1.6
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.9 -1.4 -1.0 0.4
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.9 1.4 0.9 -0.5
High cholesterol (Self-reported) 0.3 0.6 1.2 -0.7 -1.1 0.3
Medication: Bendroflumethiazide 0.5 0.8 1.3 -0.9 -1.1 0.5
Medication: Paracetamol 1.7 2.6 7.2 0.8 0.2 2.7
Medication: Lisinopril 1.7 2.2 4.4 -0.8 -2.1 1.3
Medication: Atorvastatin 0.5 0.6 0.6 0.8 0.7 0.8
Illnesses of father: High blood pressure 0.4 0.5 1.3 0.1 0.3 -1.1
Alcohol drinker status: Never 0.4 0.4 0.6 -0.8 -0.7 0.5
Ever smoked 0.3 0.5 1.4 -0.1 0.0 -1.2
Basal metabolic rate 0.5 3.0 3.8 1.3 1.9 -1.9
Leg fat percentage (left) 0.2 0.6 1.0 -0.9 -1.0 -0.2
Arm fat-free mass (left) 0.4 2.2 3.4 0.9 1.5 -1.8
Number of operations (self-reported) 0.1 0.2 0.3 -0.3 -0.4 0.6
Average weekly beer plus cider intake 0.6 0.9 1.6 -1.0 -1.2 0.5
Irritability 0.2 0.4 0.7 -0.5 -0.8 0.4
Risk taking 1.8 2.6 6.5 -1.2 0.2 -2.5
Ever had prostate specific antigen (PSA) test 1.6 1.9 2.7 1.6 1.6 0.6
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.5 -0.3 0.2
Age started oral contraceptive pill 0.5 0.6 1.5 -0.6 -0.3 -1.2
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.9 0.5 0.5
Ever depressed for a whole week 0.6 0.8 1.5 0.7 1.2 -0.5
Unable to work because of sickness or disability 1.2 1.6 2.5 -1.4 -1.6 0.3
Commuting to job workplace: Cycle 0.7 0.9 1.1 1.0 1.1 0.7
Myopia 0.4 0.5 1.3 -0.4 0.4 1.2
Vascular/heart problems diagnosed by doctor 2.0 5.5 7.7 2.3 2.8 -1.9
Cholesterol lowering medication 0.4 0.6 1.8 0.1 -0.2 1.4
Medication: Omeprazole (e.g. Zanprol) 0.9 1.0 2.8 0.1 -0.6 1.7
Pain experienced in last month 0.2 0.4 1.1 0.1 0.0 1.0
Supplements: Calcium 0.4 0.5 0.8 -0.6 -0.5 -0.9
Basal cell carcinoma (self-reported) 1.1 1.4 4.0 -0.2 -0.2 -2.0
Heart attack/myocardial infarction (self-reported) 0.5 0.7 2.0 -0.0 -0.3 1.4
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 1.9 0.5 0.8 -1.4
Heart disease (siblings) 0.3 0.4 0.4 -0.7 -0.7 0.4
Alcohol drinker status: Previous 0.6 0.7 0.8 -0.9 -0.8 0.9
Pack years of smoking 0.1 0.1 0.3 -0.5 -0.2 -0.2
Impedance of whole body 0.7 3.5 6.7 -1.5 -2.6 1.2
Leg fat mass (left) 0.1 0.2 0.5 -0.4 -0.3 -0.7
Arm predicted mass (left) 0.5 2.3 3.8 0.9 1.6 -1.9