Hub : Genes

SLC25A40

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0630	0.0280	0.0054	0.091	NA	0.053	NA	0.066	1.1e-05	NA	0.0007	NA	0.00016
2	GTEx	Ovary	0.1630	0.0740	0.0087	-0.012	NA	-0.012	NA	-0.012	9.8e-01	NA	0.9200	NA	0.94000
3	METSIM	Adipose	0.0315	0.0176	0.0170	-0.001	0.004	0.001	0.002	0.000	4.0e-01	0.078	0.2400	0.13	0.34000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.9	4.6	6.1	-1.7	-2.3	-2.5
Bipolar Disorder or Schizophrenia	3.7	9.1	19.4	-2.0	-2.0	-4.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.4	-0.3	-0.2
Depression (Nagel 2018)	0.4	0.6	1.1	0.7	1.1	-0.6
Intelligence (Savage-Jansen 2018)	0.7	2.2	2.9	1.7	1.5	1.2
Neuroticism (Nagel 2018)	0.2	0.5	0.7	-0.7	-0.5	-0.8
Schizophrenia (2018)	2.5	5.2	13.5	-1.2	-0.8	-3.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.5	-0.8	0.1
Worry (Nagel 2018)	0.6	1.3	2.2	-1.5	-1.2	-0.6
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.1	0.0	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.3	0.0	0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.2	-0.1	0.6
Crohns Disease (2017)	0.5	1.1	1.4	-1.0	-1.2	-0.9
Irritable Bowel Disease (IBD)	0.8	2.0	3.5	-1.5	-1.9	0.4
Ulcerative Colitis (UC)	0.7	1.3	2.1	-0.9	-1.4	0.9
Major Depression (MDD)	0.5	0.6	1.1	1.1	0.8	0.3
Reaction Time	0.5	0.9	2.7	0.1	0.3	-1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.5	1.6	1.1	-0.0
Breast Cancer	0.4	0.9	1.6	-1.0	-1.3	0.4
Ovarian Cancer	1.7	2.3	6.1	0.8	0.4	2.5
Prostate Cancer	0.1	0.2	0.4	0.2	0.3	-0.6
Age at First Birth	0.2	0.3	0.7	0.5	0.8	0.2
Bipolar Disorder (2011)	4.3	4.1	7.1	-1.6	-1.6	-2.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	-0.8	-0.4	0.4
Coronary Artery Disease (CAD)	0.7	0.9	2.0	0.7	0.4	1.4
Crohns Disease (2012)	0.8	1.2	1.9	-1.4	-1.3	-0.1
Mean Putamen Volume	0.1	0.2	0.2	0.3	0.5	-0.4
Fasting Glucose	0.1	0.2	0.3	0.1	0.6	-0.4
HbA1C	0.7	0.8	2.0	-0.6	-0.2	1.4
HDL Cholesterol	0.2	0.3	0.6	0.8	0.3	-0.4
LDL Cholesterol	0.3	0.5	0.6	-0.7	-0.7	0.7
Lupus	0.2	0.3	0.9	-0.3	-0.2	1.0
Neuroticism (2016)	1.7	2.4	6.6	-0.8	-0.2	-2.6
Primary Biliary Cirrhosis	1.6	2.2	5.7	-0.5	-0.9	-2.4
Rheumatoid Arthritis	0.5	0.7	1.6	1.3	0.4	0.5
Schizophrenia (2014)	2.0	4.4	10.7	-1.1	-1.2	-3.3
Triglycerides	0.6	0.9	2.7	-0.3	0.1	1.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	-0.0	0.4	-0.2
Ulcerative Colitis	0.1	0.2	0.4	-0.1	-0.3	0.6
Blood Eosinophil Count	0.4	2.8	6.5	-1.3	-0.5	-2.5
Blood Platelet Count	0.2	2.4	6.7	-0.5	-0.5	2.6
Blood Red Count	0.3	2.7	4.6	-2.1	-1.8	0.6
Blood White Count	2.0	15.0	26.1	-5.1	-4.4	0.1
Heel T-Score	0.1	0.5	1.5	-0.2	-0.3	1.2
BMI	0.0	0.1	0.4	-0.1	0.6	-0.3
Height	0.5	10.4	29.8	-0.1	1.1	-5.5
Waist Hip Ratio (WHR)	1.3	5.8	11.2	-2.5	-3.3	-0.0
Systolic Blood Pressure	0.2	1.1	3.2	-0.4	-1.8	0.1
Smoking Status	0.4	0.9	2.3	-0.3	-0.4	-1.5
Allergy or Eczema	0.1	0.3	0.7	0.4	-0.8	0.2
Cardiovascular Disease	1.4	4.6	6.4	-1.9	-2.5	1.9
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.7	-0.2	-0.6
Respiratory disease	0.3	0.6	1.4	-0.5	-1.2	0.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.2	1.5	0.8	-1.8
Lung FEV1/FVC ratio	0.1	0.7	1.2	-1.0	-0.3	-1.1
Lung FVC	0.0	0.2	0.6	0.8	-0.2	0.3
Neuroticism	1.7	4.1	4.5	-2.1	-1.8	-2.1
Chronotype (morning person)	0.1	0.2	0.4	0.1	0.3	0.7
Hair Pigment	0.0	1.4	4.1	0.3	0.2	2.0
Tanning	0.1	0.9	1.4	-0.9	-1.2	-0.7
Hand grip strength (left)	1.5	3.9	6.7	2.1	2.6	-1.0
Number of treatments/medications taken	0.6	1.1	2.8	-0.1	-0.8	1.7
Average weekly spirits intake	0.9	1.2	3.0	0.4	-0.6	1.7
Sensitivity / hurt feelings	0.5	0.8	2.3	0.0	0.5	-1.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.5	0.1	-0.8
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.6	-0.3	-0.9
Relative age of first facial hair	0.6	1.3	3.6	0.3	-0.3	1.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.4	0.2	0.1	1.6
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.2	-1.8	-1.6	-0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.8	0.3	-0.1
Systolic blood pressure, automated reading	0.4	1.3	2.0	-0.5	-1.4	-1.3
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.2	2.3	1.4	1.5
Angina	0.2	0.3	0.4	-0.5	-0.3	0.6
Medication for hormone replacement therapy	2.4	2.7	4.2	-1.8	-2.0	0.8
Vitamin and mineral supplements	0.3	0.5	1.0	-1.0	-0.6	-0.0
Supplements: Zinc	1.7	1.9	3.2	1.5	1.8	-0.5
Medication: Co-codamol	0.1	0.1	0.1	0.2	-0.3	-0.3
Medication: Metformin	1.9	2.7	4.3	2.1	1.6	-1.2
Diabetes (father)	1.1	1.3	1.6	-1.0	-1.2	1.3
Diabetes (mother)	2.1	2.6	4.0	-1.8	-2.0	0.8
Severe depression (siblings)	1.9	2.1	5.9	-0.6	0.1	-2.4
Pack years adult smoking proportion	0.1	0.2	0.4	-0.6	-0.3	-0.1
Impedance of leg (right)	0.6	3.1	5.7	-1.1	-2.4	1.6
Leg fat-free mass (left)	0.5	2.8	3.9	1.1	1.9	-2.0
Trunk fat percentage	0.3	1.0	1.3	-0.8	-1.0	-1.1
Hand grip strength (right)	1.8	4.8	7.5	2.5	2.7	-0.8
Townsend deprivation index at recruitment	1.7	2.4	2.9	-1.7	-1.6	-1.3
Current tobacco smoking	0.1	0.2	0.5	-0.1	0.2	-0.7
Average weekly fortified wine intake	0.5	0.6	0.8	-0.9	-0.9	0.7
Maternal smoking around birth	0.0	0.1	0.1	0.1	-0.3	-0.3
Fed-up feelings	0.3	0.5	1.4	0.1	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.2	0.5	-1.0
Relative age voice broke	1.0	1.5	3.6	0.7	0.5	1.9
Taking other prescription medications	1.0	1.6	2.8	-1.2	-1.7	0.8
Age when periods started (menarche)	0.2	0.6	1.3	-0.6	-1.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.4	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.4	1.6	1.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.6	-0.8	-0.4	-0.0
Qualifications: CSEs or equivalent	0.5	0.6	1.1	1.0	0.9	0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.7	-0.1	-0.9	0.3
High blood pressure	1.3	3.6	5.6	-1.8	-2.4	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	-0.2	-1.3	-0.0
Multivitamins +/- minerals	0.6	0.8	1.7	1.3	0.7	0.5
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.5	0.3	-0.7
Supplements: Glucosamine	0.7	0.9	1.7	1.3	1.0	-0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.8	-0.6	0.1
Medication: Atenolol	2.0	2.5	3.6	-1.9	-1.7	0.9
Medication: Levothyroxine sodium	1.1	1.8	2.8	-1.7	-1.4	0.8
Sitting height	0.4	3.1	8.7	0.4	0.7	-3.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.2	-1.1	-0.9	-0.3
High blood pressure (mother)	0.6	0.8	2.0	0.6	0.3	1.4
Body mass index (BMI)	0.0	0.1	0.1	0.2	0.4	-0.3
Impedance of leg (left)	0.7	3.3	5.6	-1.2	-2.4	1.7
Leg predicted mass (left)	0.5	2.9	4.1	1.0	1.8	-2.0
Trunk fat mass	0.2	0.8	1.9	-0.5	-0.5	-1.4
Waist circumference	0.1	0.5	0.8	-0.4	-0.7	-0.9
Number of incorrect matches in round	1.2	2.0	5.0	-0.9	-0.5	-2.2
Past tobacco smoking	0.4	0.8	1.5	0.7	1.2	0.7
Alcohol usually taken with meals	0.6	0.9	1.4	-1.2	-1.1	0.3
Nervous feelings	0.5	1.0	1.9	-1.0	-0.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.7	-1.5	-0.7	-1.9
Hearing difficulty/problems with background noise	0.6	1.0	2.7	-0.1	0.7	-1.6
Hair/balding pattern: Pattern 2	0.5	0.7	0.7	-0.9	-0.7	-0.9
Had menopause	0.7	0.9	1.6	-0.6	-0.8	-1.3
Had other major operations	0.6	0.8	1.1	-1.0	-0.8	0.7
Forced vital capacity (FVC)	0.2	0.8	2.1	1.4	0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.8	0.9	0.9	0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.2	-0.9	0.0	-1.1
Qualifications: None of the above	0.8	1.7	3.3	-1.8	-1.3	-0.4
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.3	-0.4	0.6
Mouth/teeth dental problems	0.8	1.2	2.2	0.8	0.9	1.5
Heart attack	0.5	0.7	1.9	0.1	-0.3	1.4
Allergy	0.5	1.1	2.7	0.8	1.6	0.3
Pain all over the body in last month	0.0	0.0	0.1	0.1	-0.0	-0.2
Diabetes (self-reported)	0.6	0.9	1.4	1.2	0.5	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.4	-0.5	-1.2	-0.1
Medication: Ramipril	0.9	1.1	2.7	-0.4	-0.7	-1.6
Medication: Simvastatin	0.4	0.6	1.5	-0.5	-1.2	0.3
Fluid intelligence score	1.3	2.8	4.4	2.1	1.5	1.3
Illnesses of siblings	0.1	0.2	0.3	0.3	0.5	-0.5
Neuroticism score	1.2	2.5	2.9	-1.7	-1.4	-1.7
Weight	0.2	0.9	1.9	0.4	0.7	-1.4
Impedance of arm (right)	0.7	3.1	6.0	-1.7	-2.5	0.7
Arm fat percentage (right)	0.1	0.3	0.3	-0.5	-0.6	-0.5
Trunk fat-free mass	0.6	3.7	5.3	1.5	2.3	-1.9
Hip circumference	0.3	1.4	3.5	0.6	0.6	-1.9
Time employed in main current job	0.6	0.6	1.8	0.2	-0.3	1.3
Alcohol intake versus 10 years previously	1.2	1.8	3.0	0.9	1.3	-1.7
Father’s age at death	0.3	0.4	1.1	0.3	0.4	1.0
Worrier / anxious feelings	0.9	1.7	2.5	-1.6	-1.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.1	-1.1	-1.0	0.3
Falls in the last year	3.3	4.5	7.4	-2.4	-2.7	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	2.9	1.7	1.2	0.3
Number of live births	0.4	0.5	1.1	-0.5	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.4	1.2	0.3	-0.3
Pulse rate	0.4	0.7	0.9	-0.9	-0.9	0.7
Happiness	0.5	0.6	1.7	-0.1	0.2	-1.3
Noisy workplace	1.1	1.4	1.7	-1.3	-1.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	3.7	1.9	1.8	1.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.2	-0.8	-1.5	0.3
Asthma	0.8	1.6	2.5	-1.1	-1.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.0	-0.0	0.1
Medication: Cholesterol lowering	0.3	0.5	0.7	-0.7	-0.9	0.6
Depression (self-reported)	1.2	1.4	1.7	-1.3	-1.1	1.2
Medication: Lansoprazole	1.0	1.1	1.9	0.9	0.8	1.4
Prospective memory result	2.6	3.2	4.8	-2.2	-2.1	-0.6
Lung cancer (father)	0.3	0.3	0.6	0.7	0.5	0.4
Illnesses of mother	0.1	0.1	0.1	0.3	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	1.1	0.4	0.1
Pulse wave Arterial Stiffness index	1.4	1.6	3.0	-1.7	-1.3	-0.3
Impedance of arm (left)	0.5	2.2	4.6	-1.2	-2.1	0.6
Arm fat mass (right)	0.1	0.3	0.8	0.0	0.0	-0.9
Trunk predicted mass	0.6	3.4	5.0	1.4	2.2	-1.8
Standing height	0.2	2.4	6.1	0.6	0.9	-2.5
Length of working week for main job	0.1	0.1	0.3	-0.1	0.3	0.6
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.9	-0.3	0.4
Breastfed as a baby	1.3	1.6	2.1	1.4	1.2	1.1
Tense / ‘highly strung’	1.2	2.0	3.1	-1.8	-1.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	5.1	-2.3	-1.6	-0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.4	-0.4	0.9
Birth weight of first child	0.3	0.6	1.4	-0.6	-0.1	-1.2
Peak expiratory flow (PEF)	0.2	0.4	1.1	1.1	0.4	-0.3
Pulse wave reflection index	0.3	0.3	1.0	0.1	-0.1	1.0
Ever highly irritable/argumentative for 2 days	2.4	2.9	5.3	1.8	2.3	-0.3
Loud music exposure frequency	0.4	0.5	1.0	0.2	1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.5	-0.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.4	-0.3	-0.2	-1.6
Blood clot in the leg (DVT)	0.7	0.9	1.5	0.6	0.9	-1.2
Medication: Paracetamol	1.1	1.8	3.4	1.3	0.5	1.8
Headache pain in last month	3.2	5.5	9.6	-3.1	-2.6	0.3
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	5.6	2.2	2.4	-0.3
Glaucoma (self-reported)	1.0	1.2	2.0	-1.0	-1.4	0.6
Gout (self-reported)	0.5	0.6	1.8	-0.3	-0.2	1.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	-0.8	-0.4	0.2
Medication: Amlodipine	0.1	0.1	0.1	0.3	-0.3	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	0.5	-0.3	1.5
Birth weight	0.0	0.1	0.1	0.1	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.0	-1.4	-0.2	-1.0
High blood pressure (siblings)	0.2	0.3	0.8	0.3	0.1	0.9
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	1.2	0.2	-0.2
Body fat percentage	0.2	0.7	1.0	-0.7	-1.0	-0.8
Leg fat percentage (right)	0.1	0.4	0.7	-0.6	-0.9	-0.2
Arm fat-free mass (right)	0.6	3.0	3.9	1.4	2.0	-1.8
Exposure to tobacco smoke outside home	0.5	0.6	1.1	-1.1	-0.3	0.8
Comparative body size at age 10	0.1	0.4	0.9	0.4	0.9	0.4
Number of full brothers	0.6	0.8	1.2	0.9	1.1	-0.6
Worry too long after embarrassment	0.3	0.5	1.0	-0.3	-0.7	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.7	-1.3	-0.5	-1.9
Wheeze or whistling in the chest in last year	0.4	0.8	1.1	-0.8	-0.8	-1.0
Number of children fathered	2.2	2.5	4.3	1.8	2.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.0	0.7	1.0	-0.7
Age at first live birth	0.5	0.8	1.5	0.9	1.2	-0.2
Pulse wave peak to peak time	1.3	1.6	2.9	1.7	1.4	0.2
Health satisfaction	0.1	0.1	0.2	0.3	0.1	0.5
Shortness of breath walking on level ground	2.4	2.9	4.8	-1.9	-2.2	-0.6
Qualifications: College or University degree	0.5	1.6	2.5	-1.2	-1.0	-1.6
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.6	0.1	-0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	-1.1	-0.8	0.1
Emphysema/chronic bronchitis	1.7	1.9	3.2	-1.8	-1.4	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	2.2	-0.7	0.0	-1.5
Neck or shoulder pain in last month	1.1	1.5	2.4	-1.2	-1.6	0.8
Medication: Blood pressure	0.8	1.4	2.6	-1.3	-1.6	-0.2
Angina (self-reported)	0.1	0.1	0.1	-0.3	-0.1	0.3
Migraine (self-reported)	1.6	2.0	3.2	-1.2	-1.2	1.8
Medication: Ibuprofen	0.0	0.0	0.1	-0.0	0.2	0.0
Medication: Allopurinol	0.7	0.9	1.0	-0.9	-0.9	1.0
Medication: Omeprazole	1.3	1.5	3.8	-0.2	-0.8	2.0
Medication: Seretide 50 evohaler	1.1	1.3	2.3	-1.1	-1.5	0.6
Mean time to correctly identify matches	0.5	0.9	2.5	0.0	0.4	-1.6
Heart disease (mother)	1.1	1.4	3.4	0.4	0.8	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.0	-0.2	-0.5	1.4
Whole body fat mass	0.2	0.7	1.7	-0.4	-0.4	-1.3
Leg fat mass (right)	0.0	0.2	0.5	-0.1	-0.2	-0.7
Arm predicted mass (right)	0.6	2.9	3.5	1.3	1.8	-1.9
Pulse rate, automated reading	1.4	4.7	7.6	-2.5	-2.8	0.7
Alcohol intake frequency.	0.3	0.8	1.8	0.0	0.7	-1.3
Comparative height size at age 10	0.2	1.0	2.0	0.7	0.8	-1.4
Number of full sisters	0.1	0.1	0.2	-0.5	-0.3	0.1
Suffer from ‘nerves’	0.0	0.0	0.0	-0.2	-0.2	-0.0
Overall health rating	1.4	2.9	5.7	-1.7	-2.4	0.4
Chest pain or discomfort	0.1	0.1	0.2	-0.3	-0.4	0.5
Had major operations	1.3	1.5	2.8	-1.3	-1.7	-0.1
Age at last live birth	0.2	0.2	0.6	-0.2	0.3	-0.7
Family relationship satisfaction	0.2	0.3	0.7	-0.2	0.1	0.8
Leg pain on walking	0.3	0.4	0.7	0.7	0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.6	1.4	1.6	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	0.6	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.7	-0.3	0.2
Medication: Aspirin	0.1	0.1	0.3	0.6	-0.0	-0.3
Supplements: Vitamin C	0.6	0.7	0.9	0.7	1.0	-0.9
Knee pain experienced in last month	0.2	0.3	0.6	-0.5	-0.1	-0.8
Hypertension (Self-reported)	1.9	5.3	8.6	-2.4	-2.9	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	6.2	-0.2	-0.1	2.5
Illnesses of father: Heart disease	2.2	3.0	5.2	2.3	1.9	0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.9	0.8	0.1
Smoking status: Previous	1.6	2.4	4.7	-1.5	-2.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	8.3	2.9	1.6	0.6
Whole body fat-free mass	0.6	3.5	4.8	1.3	2.2	-2.0
Leg fat-free mass (right)	0.6	3.1	4.4	1.2	2.1	-1.9
Arm fat percentage (left)	0.1	0.3	0.3	-0.4	-0.5	-0.6
Average weekly red wine intake	1.2	1.8	2.5	-1.5	-1.6	-0.6
Handedness (chirality/laterality): Left-handed	1.2	1.4	1.9	-1.3	-0.7	-1.4
Mood swings	0.3	0.6	0.9	0.9	0.9	-0.5
Loneliness, isolation	0.9	1.2	2.5	0.7	1.6	-0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.3	-0.3	1.2
Ever had bowel cancer screening	4.7	5.5	8.5	-2.9	-2.8	-0.4
Diabetes diagnosed by doctor	1.2	1.9	2.6	1.6	1.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	2.9	-1.6	-1.7	-1.1
Friendships satisfaction	0.2	0.3	0.6	-0.1	0.5	0.7
Qualifications: nursing, teaching	1.9	3.0	4.4	2.0	2.1	-0.6
Commuting to job workplace: Walk	4.0	4.3	7.4	-2.3	-2.7	-0.0
Eye problems/disorders: Cataract	1.0	1.1	1.9	-0.8	-0.9	1.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.2	0.6	-0.2
Medication for cholesterol	1.3	2.0	3.0	1.0	1.4	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.9	0.6	-0.0	2.0
Back pain experienced in last month	0.5	0.7	2.0	-0.1	0.4	-1.4
Mineral and other dietary supplements	1.8	2.4	3.9	-2.0	-1.6	0.9
Breast cancer (self-reported)	0.2	0.2	0.3	0.4	0.3	-0.6
Asthma (self-reported)	0.8	1.6	2.2	-1.0	-1.5	1.3
Osteoporosis (self-reported)	3.4	4.2	7.0	2.6	2.3	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.0	-0.7	0.1
Medication: Aspirin	0.1	0.2	0.3	0.6	0.2	-0.5
Medication: Gliclazide	0.4	0.5	0.6	0.8	0.8	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.1	0.2	0.7
Smoking status: Current	0.2	0.3	0.4	0.4	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	1.3	0.6	0.3
Whole body water mass	0.6	3.5	4.8	1.3	2.2	-2.0
Leg predicted mass (right)	0.7	3.5	5.0	1.3	2.2	-1.9
Arm fat mass (left)	0.1	0.2	0.7	0.0	0.1	-0.9
Number of self-reported non-cancer illnesses	3.4	5.9	7.7	-2.5	-2.8	2.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.5	0.4	0.9
Miserableness	0.1	0.2	0.4	-0.1	-0.4	0.7
Guilty feelings	1.2	1.9	2.3	-1.5	-1.4	-1.1
Wears glasses or contact lenses	0.1	0.1	0.2	0.1	0.4	-0.3
Ever taken oral contraceptive pill	1.2	1.4	3.6	1.9	0.6	0.4
Hearing aid user	0.9	1.0	1.5	-0.5	-1.1	1.2
Mother’s age at death	0.6	0.8	1.4	1.2	1.0	-0.1
Financial situation satisfaction	1.0	1.2	2.5	1.0	1.6	0.4
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.3	-0.3	-0.4	1.5
Commuting to job workplace: Public transport	0.3	0.4	0.5	0.5	0.7	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.5	-1.0	0.5
Medication: Blood pressure	1.0	1.9	2.7	-0.8	-1.5	1.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	-1.4	-1.0	0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.9	1.4	0.9	-0.5
High cholesterol (Self-reported)	0.3	0.6	1.2	-0.7	-1.1	0.3
Medication: Bendroflumethiazide	0.5	0.8	1.3	-0.9	-1.1	0.5
Medication: Paracetamol	1.7	2.6	7.2	0.8	0.2	2.7
Medication: Lisinopril	1.7	2.2	4.4	-0.8	-2.1	1.3
Medication: Atorvastatin	0.5	0.6	0.6	0.8	0.7	0.8
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.1	0.3	-1.1
Alcohol drinker status: Never	0.4	0.4	0.6	-0.8	-0.7	0.5
Ever smoked	0.3	0.5	1.4	-0.1	0.0	-1.2
Basal metabolic rate	0.5	3.0	3.8	1.3	1.9	-1.9
Leg fat percentage (left)	0.2	0.6	1.0	-0.9	-1.0	-0.2
Arm fat-free mass (left)	0.4	2.2	3.4	0.9	1.5	-1.8
Number of operations (self-reported)	0.1	0.2	0.3	-0.3	-0.4	0.6
Average weekly beer plus cider intake	0.6	0.9	1.6	-1.0	-1.2	0.5
Irritability	0.2	0.4	0.7	-0.5	-0.8	0.4
Risk taking	1.8	2.6	6.5	-1.2	0.2	-2.5
Ever had prostate specific antigen (PSA) test	1.6	1.9	2.7	1.6	1.6	0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.5	-0.3	0.2
Age started oral contraceptive pill	0.5	0.6	1.5	-0.6	-0.3	-1.2
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.9	0.5	0.5
Ever depressed for a whole week	0.6	0.8	1.5	0.7	1.2	-0.5
Unable to work because of sickness or disability	1.2	1.6	2.5	-1.4	-1.6	0.3
Commuting to job workplace: Cycle	0.7	0.9	1.1	1.0	1.1	0.7
Myopia	0.4	0.5	1.3	-0.4	0.4	1.2
Vascular/heart problems diagnosed by doctor	2.0	5.5	7.7	2.3	2.8	-1.9
Cholesterol lowering medication	0.4	0.6	1.8	0.1	-0.2	1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.8	0.1	-0.6	1.7
Pain experienced in last month	0.2	0.4	1.1	0.1	0.0	1.0
Supplements: Calcium	0.4	0.5	0.8	-0.6	-0.5	-0.9
Basal cell carcinoma (self-reported)	1.1	1.4	4.0	-0.2	-0.2	-2.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.0	-0.0	-0.3	1.4
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	1.9	0.5	0.8	-1.4
Heart disease (siblings)	0.3	0.4	0.4	-0.7	-0.7	0.4
Alcohol drinker status: Previous	0.6	0.7	0.8	-0.9	-0.8	0.9
Pack years of smoking	0.1	0.1	0.3	-0.5	-0.2	-0.2
Impedance of whole body	0.7	3.5	6.7	-1.5	-2.6	1.2
Leg fat mass (left)	0.1	0.2	0.5	-0.4	-0.3	-0.7
Arm predicted mass (left)	0.5	2.3	3.8	0.9	1.6	-1.9