Hub : Genes

SLC2A12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2060	0.0410	1.1e-07	0.113	0.059	0.111	0.121	0.150	1.2e-13	9.9e-08	1.9e-13	1.7e-14	7.3e-18
2	GTEx	Artery Tibial	0.2371	0.0582	2.9e-05	0.131	NA	0.100	NA	0.117	2.1e-10	NA	3.0e-08	NA	1.9e-09
3	GTEx	Stomach	0.3340	0.0980	7.5e-03	0.021	NA	0.020	NA	0.013	3.3e-02	NA	3.6e-02	NA	7.4e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.1237	0.0319	5.1e-05	0.111	0.023	0.106	0.079	0.091	3.8e-14	4.6e-04	1.6e-13	2.3e-10	9.1e-12
5	TCGA	Bladder Urothelial Carcinoma	0.0710	0.0310	6.9e-04	0.059	0.035	0.048	NA	0.043	9.5e-06	5.7e-04	6.4e-05	NA	1.5e-04
6	TCGA	Breast Invasive Carcinoma	0.0371	0.0134	5.6e-06	0.036	0.027	0.028	NA	0.031	4.6e-08	2.5e-06	1.8e-06	NA	4.6e-07
7	TCGA	Cervical Squamous Cell Carcinoma	0.1940	0.0820	1.2e-03	-0.005	0.082	0.019	NA	-0.001	6.6e-01	7.8e-05	3.7e-02	NA	3.7e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0791	0.0276	1.8e-05	0.033	0.035	0.038	NA	0.035	1.1e-04	7.8e-05	3.5e-05	NA	7.8e-05
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0840	0.0410	3.2e-03	-0.003	0.035	0.041	NA	0.028	5.0e-01	4.1e-03	2.1e-03	NA	9.8e-03
10	TCGA	Brain Lower Grade Glioma	0.0938	0.0327	4.7e-07	0.042	0.070	0.073	NA	0.055	1.4e-05	2.1e-08	1.1e-08	NA	7.0e-07
11	TCGA	Pancreatic Adenocarcinoma	0.0870	0.0430	9.0e-03	0.078	0.048	0.072	NA	0.067	3.7e-04	4.3e-03	6.1e-04	NA	8.9e-04
12	TCGA	Stomach Adenocarcinoma	0.1080	0.0480	3.3e-03	0.007	0.010	0.006	NA	-0.003	8.9e-02	6.3e-02	1.0e-01	NA	6.4e-01
13	TCGA	Thyroid Carcinoma	0.1140	0.0380	1.0e-06	0.006	0.024	0.023	NA	0.020	7.1e-02	1.9e-03	2.5e-03	NA	3.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.3	2.1	5.4	-0.8	0.7	-0.3	-0.6	-0.3	-2.3	-2.0	-1.5	0.0	-2.2	1.1	-1.8	-2.0
Bipolar Disorder or Schizophrenia	0.1	0.2	1.2	0.5	1.1	0.1	0.5	-0.9	-0.4	-0.2	-0.1	0.0	-0.0	-0.2	-0.2	-0.1
Depressed Affect (Nagel 2018)	0.3	0.7	2.3	0.5	-0.1	-0.4	0.6	0.7	1.5	0.5	1.1	0.5	0.9	0.2	1.4	1.1
Depression (Nagel 2018)	0.2	0.3	1.8	0.2	-0.1	-0.4	0.2	0.8	-0.2	-0.7	-0.5	0.3	1.3	0.1	0.5	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.7	0.7	0.8	1.5	0.6	-1.9	-1.5	-0.1	-0.9	-2.2	0.0	-1.8	-1.8	-0.8
Neuroticism (Nagel 2018)	0.2	0.6	2.3	-0.2	-1.0	-0.3	-0.1	-0.8	1.5	-0.9	-0.2	-0.9	0.5	-0.7	0.9	-0.1
Schizophrenia (2018)	0.6	1.3	2.7	1.3	0.9	0.4	1.1	-1.0	1.4	1.5	0.9	0.0	1.6	-1.1	1.1	1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	4.1	1.0	0.3	-0.2	1.1	0.3	1.3	1.2	2.0	0.0	1.5	-0.6	1.6	1.5
Worry (Nagel 2018)	0.3	0.5	1.5	0.0	-0.8	-0.8	-0.1	-0.7	0.8	-1.1	-1.2	-0.7	0.5	-0.3	-0.0	-1.0
Alzheimer’s Disease (in mother)	1.7	2.0	6.7	-1.9	-1.6	1.9	-1.4	-2.6	-0.0	-0.4	-0.2	-1.3	-0.0	-2.3	-0.5	-0.1
Alzheimer’s Disease (in father)	1.5	1.7	4.0	0.7	1.2	-0.9	0.9	1.6	0.7	1.9	1.2	1.2	0.5	2.0	1.3	1.6
Alzheimer’s Disease (including proxy)	0.7	1.0	4.8	-1.0	-0.5	2.2	-0.4	-1.6	0.0	1.0	0.2	-0.6	0.6	-0.9	-0.2	1.0
Crohns Disease (2017)	1.3	2.8	7.9	0.6	-1.3	-1.1	-0.1	2.2	2.8	0.0	1.4	2.8	2.4	0.5	1.7	1.6
Irritable Bowel Disease (IBD)	1.2	2.9	6.0	1.3	0.1	-2.2	0.8	2.5	1.9	0.5	2.2	2.4	1.2	1.4	2.1	1.3
Ulcerative Colitis (UC)	1.0	1.9	5.0	1.5	1.3	-2.2	1.2	1.9	0.1	0.9	1.6	1.0	-0.5	1.6	1.6	0.5
Major Depression (MDD)	0.3	0.3	1.5	0.3	0.1	0.2	0.4	-0.5	-0.8	0.3	-0.8	-0.2	-0.6	-1.2	-0.8	-0.4
Reaction Time	1.1	2.1	5.3	2.3	1.4	-0.0	1.9	-1.2	-0.7	-1.0	-1.8	-2.3	-1.2	-1.3	-0.7	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.6	0.3	0.1	1.4	0.1	-0.5	-0.0	-1.0	-0.6	-0.6	1.1	-1.6	-0.2	-0.0
Breast Cancer	0.5	1.3	4.2	0.9	0.5	2.0	1.0	-0.7	0.3	1.3	-0.8	-1.1	1.7	-1.4	-0.3	1.0
Ovarian Cancer	0.4	0.5	3.7	0.1	-0.2	-1.9	-0.2	0.8	0.2	0.2	0.1	-0.4	0.1	0.5	1.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.6	7.8	1.0	0.9	-0.8	0.1	2.0	0.0	-0.1	1.8	2.8	-0.8	0.8	1.2	0.6
Bipolar Disorder (2011)	0.1	0.1	1.5	-0.2	1.2	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	4.0	-0.2	-0.6	1.3	0.1	-1.0	1.5	0.2	0.2	-0.2	0.1	-2.0	-0.0	0.8
Coronary Artery Disease (CAD)	0.8	0.9	3.7	1.9	1.9	0.3	1.5	0.2	-0.3	1.1	0.3	0.2	-0.4	-0.6	-0.4	0.4
Crohns Disease (2012)	0.5	0.8	2.8	0.7	-0.2	-1.3	0.2	1.2	1.2	-0.8	-0.4	0.0	1.7	0.6	1.0	0.4
Mean Putamen Volume	0.8	0.9	3.1	-0.2	0.1	1.6	-0.1	-1.4	1.0	-0.2	1.0	0.1	-0.8	-1.8	-0.0	1.1
Fasting Glucose	0.1	0.1	0.6	-0.2	-0.1	0.5	0.2	0.0	-0.2	0.4	-0.1	-0.8	-0.0	0.2	-0.7	0.5
HbA1C	0.9	1.0	2.4	0.1	0.7	-1.0	0.5	0.9	-1.3	1.3	1.2	1.1	-0.6	0.8	1.6	0.9
HDL Cholesterol	0.4	0.6	1.4	-0.5	-0.4	0.7	-0.6	-0.5	0.8	1.0	0.5	0.6	0.9	-1.1	1.0	1.2
LDL Cholesterol	0.7	1.0	3.4	0.5	1.8	0.9	1.0	-0.4	-1.7	1.1	-0.3	-1.6	-1.1	-0.0	-0.3	-0.1
Lupus	0.2	0.3	1.1	-0.7	-0.2	-0.4	-0.9	-0.4	-0.5	-0.5	-0.2	-0.7	-1.1	-0.0	-0.1	-0.8
Neuroticism (2016)	0.6	0.8	2.5	0.3	0.5	-1.6	0.5	-0.2	-1.0	-0.8	-1.2	-1.0	-0.8	-0.3	-0.5	-1.6
Primary Biliary Cirrhosis	0.6	0.9	3.0	-1.6	-0.6	0.5	-1.0	-0.7	-1.2	-1.7	-0.9	0.0	-0.7	-0.3	0.0	-1.2
Rheumatoid Arthritis	0.7	1.0	3.5	-1.5	-1.7	-0.3	-1.9	-0.3	0.3	-0.6	-0.2	-0.6	-1.3	-0.6	-0.8	-0.4
Schizophrenia (2014)	0.3	0.7	2.7	0.8	1.1	0.8	1.1	-1.6	-0.0	0.1	0.2	0.0	0.4	-1.4	0.0	0.0
Triglycerides	0.2	0.4	1.5	0.6	0.6	-0.3	0.8	1.2	0.1	0.7	0.1	0.0	0.2	1.1	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.9	3.0	-0.2	-1.2	-0.0	-0.4	0.2	0.4	-1.7	-0.6	-1.4	1.4	0.5	-1.1	-0.8
Ulcerative Colitis	0.6	0.9	2.6	0.9	1.6	-1.5	1.3	0.9	-1.0	0.6	0.2	0.0	-0.4	1.4	-0.0	-0.2
Blood Eosinophil Count	0.2	1.2	4.9	-0.3	1.3	0.3	0.3	1.4	-1.7	0.5	0.8	1.5	-0.7	2.2	-0.6	0.3
Blood Platelet Count	0.6	7.0	23.3	1.1	-0.8	0.5	0.1	1.1	4.1	1.8	4.8	3.7	0.6	-2.2	3.2	3.9
Blood Red Count	0.3	2.8	9.6	0.3	1.4	0.8	1.4	-1.8	-2.7	-1.3	-1.6	-3.1	-1.8	-0.2	-1.4	-1.5
Blood White Count	0.0	0.3	1.3	0.3	0.6	0.8	0.4	-0.2	-0.4	-0.3	1.2	0.1	-0.8	-0.5	-0.7	0.3
Heel T-Score	0.2	1.6	6.0	0.3	-0.0	-0.6	0.4	-2.5	-1.5	-1.7	-0.0	-1.5	-1.4	-1.1	-0.3	-1.9
BMI	0.1	0.8	4.8	-1.1	0.5	-0.5	-0.1	0.5	-1.6	0.2	-0.0	0.8	-2.2	0.8	-0.1	-0.7
Height	0.2	4.5	14.3	-0.6	-1.3	0.8	-1.1	-3.5	-0.2	-2.8	-2.4	-2.3	-2.2	-3.8	-1.0	-1.8
Waist Hip Ratio (WHR)	0.2	0.8	3.8	-0.0	-0.5	0.4	-0.5	-1.6	0.3	-0.7	-0.1	-1.2	0.4	-1.9	0.9	-0.6
Systolic Blood Pressure	1.9	9.3	27.1	2.8	0.1	-1.6	2.4	1.4	5.2	3.3	3.5	2.2	4.0	-0.1	3.9	4.0
Smoking Status	0.2	0.5	1.5	-0.9	-0.5	0.5	-0.7	0.6	-0.2	1.1	0.1	0.5	0.6	1.2	-0.2	0.3
Allergy or Eczema	0.8	2.0	11.3	-0.1	-0.2	2.3	-0.3	-2.4	0.9	0.5	0.2	-1.3	-0.3	-3.4	0.4	1.1
Cardiovascular Disease	0.2	0.6	2.7	-0.5	-0.7	0.5	-0.4	-1.4	1.2	0.5	-0.4	0.1	0.1	-1.6	0.3	0.3
Hypothyroidism (self reported)	0.4	1.0	3.8	0.6	1.3	-1.9	1.0	1.5	-0.6	-0.5	-0.1	0.7	-1.4	0.6	-0.3	-0.4
Respiratory disease	0.9	2.1	7.1	1.9	0.9	-1.3	1.5	1.2	1.9	0.3	2.7	1.1	0.4	0.8	1.9	1.1
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.9	-1.5	-1.5	-0.1	-1.5	-0.9	-0.7	-2.0	-2.2	-0.3	-1.6	-1.5	-0.8	-1.9
Lung FEV1/FVC ratio	1.1	5.5	15.8	-2.1	-4.0	2.7	-2.7	-0.9	3.0	-0.1	1.2	1.8	3.1	-2.5	1.1	2.2
Lung FVC	3.3	16.8	31.7	-4.3	-4.1	2.1	-4.2	-5.6	-2.0	-4.0	-5.4	-4.6	-2.1	-4.2	-3.9	-4.6
Neuroticism	0.1	0.2	0.7	0.2	-0.6	0.4	-0.0	-0.4	0.7	-0.8	-0.2	-0.6	0.1	-0.7	0.2	-0.2
Chronotype (morning person)	0.5	1.2	3.3	-1.7	-1.3	0.5	-1.8	-0.7	-1.3	-0.6	0.7	-1.0	-1.2	0.4	0.8	-1.2
Hair Pigment	0.0	1.4	4.1	-0.6	-0.0	-1.6	-0.1	1.5	0.4	1.7	0.9	0.9	0.7	1.9	2.0	0.8
Tanning	0.1	0.9	3.9	0.9	1.4	-0.9	0.7	-0.7	-0.5	-0.4	-0.5	0.4	-2.0	-1.4	0.1	-0.5
Hand grip strength (left)	0.3	0.7	2.5	0.3	0.9	-1.4	0.8	0.6	-0.9	0.4	-0.5	0.7	-0.7	1.6	-0.6	-0.6
Number of treatments/medications taken	0.6	1.0	5.6	0.1	-1.1	0.4	-0.2	-0.0	2.4	0.6	-0.1	0.5	1.8	-0.8	0.9	1.1
Average weekly spirits intake	1.0	1.2	6.7	-0.4	-0.2	-0.3	-0.6	-1.0	-0.8	0.0	0.8	-0.4	-2.6	-1.6	1.8	-0.1
Sensitivity / hurt feelings	0.4	0.6	2.7	-0.1	-0.7	-0.3	-0.3	-0.8	0.7	-1.6	0.1	-0.7	-0.7	-1.2	0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.6	0.4	0.0	-0.6	0.2	1.5	1.0	-0.8	0.8	1.3	1.0	0.6	1.6	0.1
Hearing difficulty/problems: Yes	0.6	1.0	3.2	-1.1	-1.3	-0.0	-1.0	1.1	0.2	-1.8	-0.1	0.8	-0.4	0.3	-1.4	-1.2
Relative age of first facial hair	0.3	0.6	4.0	0.5	0.8	2.0	0.3	-0.4	-0.3	0.2	0.4	-0.0	-1.0	-0.9	-0.5	0.3
Other serious medical condition/disability diagnosed by doctor	3.1	4.0	11.2	3.3	2.8	-0.5	3.3	1.4	1.4	1.6	1.8	0.5	1.5	0.6	1.7	2.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.7	0.4	0.3	-0.4	0.7	-0.0	0.2	-0.3	0.3	0.3	-0.4	-0.9	-0.3	0.2
Ever had hysterectomy (womb removed)	1.3	1.4	3.9	0.6	0.6	1.8	0.8	-1.8	0.0	-0.1	-0.0	-1.9	-0.9	-2.0	-1.6	0.1
Systolic blood pressure, automated reading	1.2	3.4	6.4	2.3	1.3	-2.0	2.5	1.2	2.5	1.8	2.1	0.8	1.7	0.5	1.9	1.9
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	3.1	0.2	0.4	-0.6	0.1	1.2	1.3	0.4	1.2	1.8	-0.0	0.0	1.3	1.4
Angina	1.2	1.6	4.3	2.1	1.2	-0.8	2.1	0.5	1.0	1.4	1.1	0.9	1.6	-0.0	1.4	1.0
Medication for hormone replacement therapy	0.7	0.7	3.3	0.6	-0.0	0.5	0.4	-1.8	0.2	0.0	-0.5	-1.5	-0.3	-1.4	-1.0	-0.1
Vitamin and mineral supplements	0.4	0.5	2.5	0.0	-0.0	-0.1	0.2	0.5	1.0	1.1	0.4	0.1	1.6	1.1	0.2	0.5
Supplements: Zinc	0.3	0.3	1.2	-0.4	-0.5	-0.7	-0.6	0.1	-0.0	-1.1	0.7	0.5	-0.9	0.0	0.1	-0.4
Medication: Co-codamol	0.4	0.5	1.3	0.0	0.1	-0.5	0.5	1.1	-0.1	-0.7	-0.4	1.2	1.1	0.8	0.1	-0.4
Medication: Metformin	1.8	2.5	9.8	-2.7	-3.1	-0.2	-2.4	-0.4	0.3	-1.6	-1.5	-0.3	-0.5	-0.8	-1.2	-1.5
Diabetes (father)	0.7	0.9	2.5	0.8	1.6	1.1	1.4	-0.3	-0.5	1.4	0.8	-0.2	1.0	-0.3	0.4	0.6
Diabetes (mother)	0.8	1.0	2.5	-1.4	-1.6	1.3	-0.9	-0.8	-0.1	-1.0	-0.5	-0.9	-0.9	-1.3	-0.7	-0.5
Severe depression (siblings)	1.8	2.0	5.6	-0.1	0.1	0.3	-0.2	-1.4	-1.9	-0.7	-2.2	-2.4	-0.7	-0.3	-2.1	-2.1
Pack years adult smoking proportion	0.2	0.3	0.9	-0.3	0.6	0.4	0.0	-0.4	-0.9	0.5	0.1	-0.8	-0.9	0.4	-0.3	-0.3
Impedance of leg (right)	1.1	5.5	15.4	2.4	0.4	-0.3	1.5	2.0	3.8	1.8	1.9	2.0	3.9	1.0	2.7	3.1
Leg fat-free mass (left)	0.9	4.5	17.2	-1.6	-0.5	-0.5	-1.2	-1.4	-3.3	-2.0	-1.9	-1.7	-4.2	-0.9	-2.1	-2.8
Trunk fat percentage	0.3	1.1	3.7	-0.2	0.7	-1.0	0.2	1.1	-1.9	-0.9	-1.1	0.5	-1.9	0.6	-0.4	-1.1
Hand grip strength (right)	0.3	0.8	5.3	0.2	0.5	-0.6	0.4	-0.6	-1.5	-0.1	0.2	-0.1	-2.3	0.3	-0.8	-0.9
Townsend deprivation index at recruitment	1.4	2.0	8.0	2.1	2.8	0.3	2.4	0.6	-1.2	1.7	0.9	-0.9	-0.1	0.6	-0.2	1.0
Current tobacco smoking	0.8	1.3	4.9	0.3	2.2	1.1	1.1	0.3	-2.1	0.7	-0.7	-0.5	-0.2	1.1	-1.5	0.0
Average weekly fortified wine intake	0.3	0.3	1.7	-0.0	0.5	1.3	-0.2	-0.3	0.5	0.3	0.1	0.6	-0.1	-0.9	-0.1	0.7
Maternal smoking around birth	0.4	0.6	2.7	0.8	0.9	-0.5	1.0	0.4	0.0	0.4	-0.8	-0.6	1.6	0.7	-0.4	-0.4
Fed-up feelings	0.4	0.7	2.2	0.7	0.5	-0.5	1.0	1.5	0.5	0.5	1.3	0.6	0.1	1.3	0.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.9	1.0	0.8	-0.9	1.1	1.2	-0.3	0.2	0.4	1.1	0.8	0.4	1.4	0.1
Relative age voice broke	0.4	0.5	1.5	1.2	1.1	0.7	0.9	-1.0	0.1	-0.6	0.2	0.1	-0.3	-1.2	-0.3	-0.2
Taking other prescription medications	0.3	0.4	2.1	-0.1	-0.0	-1.4	0.4	1.3	0.5	-0.1	-0.2	1.0	-0.3	0.3	0.1	-0.3
Age when periods started (menarche)	0.2	0.4	1.8	0.5	-0.5	-0.3	-0.1	1.3	0.1	-0.1	-0.1	-0.1	1.1	1.2	0.6	0.2
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	8.5	-0.9	0.2	2.3	-0.0	-2.7	0.2	0.1	1.6	-1.9	-2.2	-2.9	-0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.4	-0.7	-0.6	0.2	-0.2	-1.2	-0.6	-1.8	-0.6	-1.0	-0.2	0.5	-0.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.3	0.1	0.5	1.2	0.2	-1.0	-0.8	-0.0	-0.1	-1.2	-1.3	-0.7	-1.5	-0.5
Qualifications: CSEs or equivalent	1.1	1.5	5.0	1.8	2.2	-0.1	1.9	-0.1	-2.0	0.2	0.3	-0.1	-1.6	0.0	0.1	-0.6
Serious illness, injury or assault to yourself	2.7	3.2	6.5	1.7	0.9	-1.3	1.3	2.1	2.4	1.8	1.6	2.0	1.8	1.0	2.5	2.0
High blood pressure	0.5	1.3	6.1	0.7	-0.5	0.3	0.7	-1.2	2.5	0.2	0.3	0.2	0.9	-2.4	0.8	1.0
Hayfever, allergic rhinitis or eczema	1.1	2.4	8.1	1.2	0.3	1.7	0.5	-0.9	1.7	1.4	1.3	0.5	0.8	-2.8	1.8	2.5
Multivitamins +/- minerals	1.5	1.9	5.2	-1.1	-1.0	0.2	-1.0	-1.5	-1.4	-2.3	-1.5	-1.2	-1.7	-1.3	-0.9	-1.5
Stomach or abdominal pain in last month	1.0	1.3	4.6	2.1	1.7	-0.3	1.8	0.6	0.7	0.6	0.8	0.8	0.5	-0.4	1.4	0.9
Supplements: Glucosamine	0.3	0.4	1.3	0.7	-0.0	0.8	0.5	-1.0	-0.4	-0.2	0.6	-0.4	-0.6	-1.1	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.5	0.9	-0.0	-2.1	0.6	1.0	2.0	0.9	1.3	1.1	1.1	-0.4	1.9	1.0
Medication: Atenolol	0.6	0.8	4.7	-0.0	-0.8	0.4	0.3	0.1	2.2	0.3	-0.1	-0.2	1.8	0.3	0.2	1.0
Medication: Levothyroxine sodium	0.8	1.3	4.8	0.7	1.0	-2.1	1.1	2.2	-0.4	-0.3	0.3	1.2	-1.3	1.3	-0.5	-0.4
Sitting height	0.4	3.0	6.1	0.0	-0.1	0.8	-0.1	-2.2	-1.6	-1.7	-1.8	-2.0	-2.3	-1.9	-2.4	-2.5
Chronic bronchitis/emphysema (father)	0.8	0.9	1.8	-1.4	-0.6	-0.0	-1.1	-1.3	-0.8	-0.7	0.5	-1.0	-1.2	-1.0	0.3	-1.2
High blood pressure (mother)	0.2	0.3	1.0	0.3	0.2	0.7	0.5	-0.5	0.6	-0.2	0.2	0.3	-0.8	-1.0	-0.6	0.3
Body mass index (BMI)	0.4	1.9	8.6	-0.6	1.3	-1.0	0.6	0.4	-2.8	-0.1	-0.9	-0.4	-2.9	0.9	-1.0	-1.3
Impedance of leg (left)	1.2	5.7	15.8	2.8	0.8	-0.1	1.6	2.0	3.4	2.0	1.8	2.2	4.0	0.7	3.0	3.1
Leg predicted mass (left)	0.8	4.4	17.2	-1.4	-0.4	-0.6	-1.1	-1.4	-3.3	-2.0	-1.9	-1.7	-4.1	-0.9	-2.1	-2.8
Trunk fat mass	0.4	1.6	6.9	-0.5	0.5	-0.9	-0.0	0.6	-2.4	-1.2	-1.4	0.1	-2.6	0.3	-0.9	-1.5
Waist circumference	0.5	1.7	8.6	-0.8	0.5	-0.4	-0.1	-0.4	-2.4	-1.0	-1.0	-0.8	-2.9	-0.8	-0.8	-1.5
Number of incorrect matches in round	0.7	1.1	4.2	0.6	0.4	0.0	0.5	-1.9	-0.1	-1.4	-1.1	-2.0	-0.9	-1.2	-0.7	-0.7
Past tobacco smoking	0.8	1.4	4.2	1.7	1.8	-0.5	2.1	0.2	-0.9	-0.8	-1.1	-1.4	-0.8	0.1	-1.4	-0.7
Alcohol usually taken with meals	1.5	2.5	16.4	1.2	-1.0	1.7	0.5	-0.3	2.6	0.8	-0.4	-0.1	4.0	-0.5	-0.1	1.4
Nervous feelings	0.3	0.6	2.2	0.0	-0.8	-1.5	0.2	0.6	0.8	-1.1	-0.6	0.1	0.8	0.1	0.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	1.2	0.6	0.2	1.0	0.7	0.8	-0.3	0.1	0.6	1.1	-0.1	0.4	0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.4	-0.1	0.9	0.1	-0.2	0.0	-0.9	0.7	-0.0	-0.7	-0.6	-0.4	-0.5
Hair/balding pattern: Pattern 2	0.6	0.7	2.5	-0.4	-0.9	0.4	-0.2	-1.2	1.2	0.3	-1.0	-1.0	1.6	-0.7	-0.1	-0.3
Had menopause	2.8	3.4	12.8	-0.4	-0.5	2.3	0.1	-3.2	0.3	-1.3	-1.1	-2.4	-1.4	-3.6	-2.3	-0.6
Had other major operations	1.4	1.7	5.5	2.0	2.2	1.3	2.4	-0.2	-0.6	1.6	-0.0	-0.9	0.9	-0.6	0.4	1.0
Forced vital capacity (FVC)	1.5	5.9	13.5	-1.2	-1.7	1.2	-1.5	-3.5	-1.4	-2.6	-3.7	-3.1	-1.2	-3.0	-2.2	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.2	-0.7	-0.4	0.2	-0.3	-0.5	-0.1	-1.1	0.0	-0.1	0.3	1.1	-0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.6	1.5	0.7	1.4	1.1	-2.2	0.7	-0.3	-0.6	-1.8	1.1	-1.5	-0.7	0.4
Qualifications: None of the above	0.2	0.3	1.3	-0.4	0.2	-0.6	-0.1	-0.1	-1.1	-0.3	-0.9	-0.3	-0.8	0.2	-0.3	-0.8
Financial difficulties in last 2 years	1.0	1.3	5.5	0.9	1.0	-2.3	0.7	0.5	-1.4	-0.5	-0.7	-0.6	-1.8	1.2	-0.4	-1.0
Mouth/teeth dental problems	1.0	1.5	4.6	-0.3	-0.8	1.4	-0.1	-2.1	0.9	1.3	0.1	-1.5	1.0	-2.2	-0.0	1.4
Heart attack	1.1	1.4	4.2	0.8	1.1	-0.6	1.1	0.3	1.2	1.5	0.6	0.5	2.0	1.5	1.8	0.9
Allergy	0.7	1.6	4.0	-2.0	-0.8	-0.5	-1.2	0.3	-1.8	-0.9	-1.1	-0.6	-0.4	2.0	-1.1	-1.8
Pain all over the body in last month	2.9	3.1	6.3	1.9	2.4	-0.0	2.2	1.7	0.7	2.5	2.1	1.8	-0.0	0.5	1.9	2.3
Diabetes (self-reported)	0.7	1.1	3.5	-1.3	-1.8	0.0	-1.2	-0.7	0.2	-1.0	-1.9	-0.4	-0.2	-0.8	-0.9	-0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	6.9	1.2	0.9	1.0	0.7	-1.9	0.6	0.1	0.1	-0.3	-0.3	-2.6	1.6	0.6
Medication: Ramipril	1.4	1.8	2.8	1.6	0.8	-1.2	1.4	1.5	1.7	1.6	1.6	1.5	0.2	0.9	0.7	1.6
Medication: Simvastatin	0.2	0.4	0.9	0.5	0.6	-0.7	0.4	0.8	0.0	1.0	0.4	0.8	-0.6	0.8	0.0	0.3
Fluid intelligence score	0.2	0.4	2.2	-0.2	-0.8	-0.1	-0.7	0.2	0.2	-1.5	-1.0	-0.1	0.6	-0.7	-0.2	-0.4
Illnesses of siblings	1.1	1.6	4.7	1.4	1.8	-0.9	1.5	1.7	-0.8	1.3	-0.4	1.1	0.5	2.2	0.7	0.6
Neuroticism score	0.1	0.2	0.9	0.2	-0.4	-0.3	0.2	-0.2	0.7	-0.8	0.3	-0.4	-0.0	-0.5	0.9	-0.3
Weight	0.6	2.8	13.8	-0.5	0.8	-1.0	0.3	-0.2	-3.2	-1.2	-1.5	-0.9	-3.7	0.1	-1.4	-2.0
Impedance of arm (right)	0.2	1.1	3.3	0.6	-0.6	-1.3	-0.4	1.8	1.7	-0.4	-0.0	1.4	1.7	0.3	1.0	0.5
Arm fat percentage (right)	0.5	2.1	8.4	-0.8	0.7	-1.8	-0.2	1.2	-2.6	-0.7	-1.2	0.2	-2.9	1.3	-0.7	-1.5
Trunk fat-free mass	0.7	4.1	13.5	-0.7	0.1	-0.2	-0.1	-2.1	-2.8	-1.8	-2.1	-2.6	-3.7	-1.2	-2.1	-2.6
Hip circumference	0.2	1.0	5.2	-0.0	0.7	-1.1	0.7	1.2	-1.6	0.3	-0.4	0.4	-2.3	0.9	-0.3	-0.5
Time employed in main current job	1.5	1.8	6.5	2.5	1.8	-1.5	2.2	1.4	1.0	0.0	1.5	0.1	0.5	0.8	0.3	0.1
Alcohol intake versus 10 years previously	0.5	0.7	2.7	-1.7	-1.2	-1.0	-1.0	-0.4	-0.1	-0.4	-0.6	-0.6	-1.0	0.2	-0.2	-0.9
Father’s age at death	0.6	0.9	2.0	0.7	0.7	-0.7	0.4	-0.5	-0.6	-1.1	-1.3	-1.4	-1.2	0.3	-1.0	-1.2
Worrier / anxious feelings	1.1	2.0	4.1	-1.4	-1.4	0.3	-1.3	-1.5	-1.0	-1.9	-1.7	-1.5	-1.1	-1.4	-1.2	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.0	2.0	1.7	0.4	2.0	-0.1	0.5	-1.0	0.5	-0.1	0.3	-0.7	0.3	-0.3
Falls in the last year	0.7	1.0	3.5	-0.3	-0.0	0.8	0.1	-1.5	-0.3	-0.0	-1.9	-1.7	-0.5	-1.6	-0.5	-0.5
Hair/balding pattern: Pattern 3	0.9	1.3	3.6	1.0	1.5	-1.4	1.0	1.9	-1.2	-0.1	0.3	0.8	-0.5	1.9	0.7	0.4
Number of live births	0.5	0.7	3.8	-0.5	0.4	1.9	0.3	-1.2	-1.4	0.1	-0.6	-0.7	0.1	-0.8	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	14.9	-1.4	-2.3	1.9	-1.9	-3.9	-0.7	-2.2	-3.0	-2.8	-0.8	-3.6	-1.7	-2.1
Pulse rate	0.1	0.2	0.7	-0.0	0.2	-0.8	-0.4	0.2	-0.3	-0.5	-0.6	-0.7	0.2	0.3	-0.4	-0.5
Happiness	0.8	0.9	3.5	1.3	1.4	-1.9	1.5	0.4	0.5	-0.3	0.6	0.3	0.6	0.0	1.1	-0.1
Noisy workplace	0.4	0.5	1.5	0.3	0.6	-0.8	0.4	-0.3	-1.1	-0.1	-0.8	-0.8	-1.2	0.5	-0.5	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	0.9	0.4	0.1	0.8	-0.7	0.5	0.5	-0.4	-1.1	0.5	0.0	1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.8	1.2	0.0	0.5	0.9	-1.1	1.7	0.2	0.0	-0.7	1.9	-1.4	0.2	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	1.5	-0.5	0.4	-0.1	-0.4	-0.1	-0.8	-0.3	0.2	-0.1	-1.2	0.5	-0.2	-0.7
Asthma	1.1	2.2	6.2	0.7	-0.2	-2.2	0.2	2.4	1.4	0.1	1.6	1.9	0.7	2.5	1.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.9	0.5	0.9	0.3	-0.2	-0.6	0.9	-0.5	-0.2	0.4	0.0	-0.9	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.1	1.0	0.7	-0.2	0.9	1.1	0.2	0.7	0.2	1.0	0.7	1.0	0.4	0.4
Depression (self-reported)	1.3	1.5	5.8	-1.0	-0.8	-1.1	-0.7	-0.8	-0.8	-2.3	-1.6	-0.9	-0.3	-0.2	-0.7	-2.4
Medication: Lansoprazole	0.9	1.0	2.6	0.8	1.0	0.2	0.8	-0.4	1.6	1.4	1.6	0.5	1.1	-0.1	1.4	0.8
Prospective memory result	0.6	0.8	4.1	0.7	0.7	-1.3	0.9	-0.2	-0.4	1.2	0.6	-0.4	-2.0	0.5	0.4	0.1
Lung cancer (father)	1.6	1.8	5.2	1.7	2.2	1.2	1.8	-0.1	-0.4	1.7	2.3	-1.1	-0.2	-0.2	0.4	1.2
Illnesses of mother	0.7	0.8	3.1	0.2	1.4	-0.2	0.6	0.8	-1.8	1.4	-0.3	0.1	0.7	1.2	0.9	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.2	14.8	-2.0	-2.5	1.3	-2.4	-3.9	-0.9	-2.2	-3.0	-2.8	-1.7	-3.8	-1.6	-2.5
Pulse wave Arterial Stiffness index	1.2	1.4	4.8	-1.4	-0.8	1.5	-1.4	-0.8	-0.9	-1.1	-1.4	-0.7	-0.3	-0.9	-2.2	-1.0
Impedance of arm (left)	0.3	1.4	4.6	0.3	-1.1	-0.3	-0.9	1.4	2.1	-0.9	0.4	1.7	1.8	-0.4	1.1	0.9
Arm fat mass (right)	0.5	2.3	10.4	-0.7	0.8	-1.4	0.0	0.5	-2.9	-0.8	-1.4	-0.4	-3.2	0.7	-0.9	-1.7
Trunk predicted mass	0.7	3.8	12.7	-0.9	-0.0	-0.2	-0.3	-2.0	-2.7	-1.8	-2.0	-2.5	-3.6	-1.2	-2.1	-2.5
Standing height	0.2	2.1	5.9	0.0	-0.9	0.2	-0.9	-1.4	-1.1	-2.4	-1.6	-1.2	-2.1	-2.0	-1.1	-1.8
Length of working week for main job	2.1	2.4	10.7	-0.2	0.0	0.1	-0.3	0.6	-2.2	-0.8	-2.4	-1.7	-0.5	1.0	-3.3	-2.0
Exposure to tobacco smoke at home	1.5	1.7	4.7	-1.3	0.3	-1.6	-1.2	2.0	-0.4	-0.7	0.3	2.2	-1.7	2.0	0.6	0.0
Breastfed as a baby	0.4	0.5	3.7	0.1	0.9	0.4	0.1	-0.3	-1.9	-0.2	-0.8	-0.1	-0.8	0.3	0.5	-0.2
Tense / ‘highly strung’	0.4	0.7	3.7	-0.5	-0.3	-0.4	-0.5	-0.5	-0.3	-1.3	-1.2	-0.9	0.3	0.6	-0.5	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.7	0.4	1.2	-0.4	0.6	-0.5	-1.9	-1.8	-1.0	-1.0	-1.8	-1.2	-0.2	-1.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.0	0.1	-0.3	0.1	0.6	-0.1	-0.6	0.0	0.1	-0.2	0.6	-0.8	-0.4
Birth weight of first child	0.3	0.5	1.5	0.1	0.3	-0.6	0.5	1.1	-0.1	0.6	-0.5	0.6	1.2	1.1	0.0	0.7
Peak expiratory flow (PEF)	1.6	3.7	13.2	-1.8	-3.6	1.9	-2.7	-2.3	2.3	-0.8	0.4	-0.2	0.8	-2.6	0.9	0.8
Pulse wave reflection index	0.8	1.0	4.9	-0.9	-0.6	2.2	-0.6	-1.0	-0.9	-0.7	-1.3	-0.5	-0.1	-1.0	-1.2	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.7	0.6	0.6	1.0	-1.1	-0.1	-1.0	-0.3	-1.1	0.2	-0.9	-0.0	-0.1
Loud music exposure frequency	0.4	0.4	1.8	-0.3	0.5	1.3	0.1	-0.4	-1.2	-0.2	-0.7	-0.1	-0.5	-0.6	-0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.3	2.0	1.5	-0.6	2.3	0.3	1.7	1.4	1.6	-0.7	1.7	0.3	1.7	1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.9	1.4	1.1	-1.2	1.3	0.7	-1.0	-0.7	-0.3	0.1	-1.0	0.3	-0.3	-0.8
Blood clot in the leg (DVT)	0.4	0.6	3.6	0.3	-0.5	-0.2	0.5	0.5	1.9	0.8	1.1	0.7	0.4	0.0	0.1	0.7
Medication: Paracetamol	0.4	0.6	1.7	1.3	1.2	1.0	1.3	0.0	-0.1	0.9	0.0	-0.6	0.4	-0.5	0.6	0.2
Headache pain in last month	0.3	0.5	2.1	1.0	-0.1	-0.6	0.6	1.2	0.6	-0.1	0.6	-0.0	0.7	1.5	0.3	0.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	5.1	-0.5	0.5	-0.2	-0.3	-1.1	-2.3	-0.9	-0.9	-1.8	-1.9	-0.5	-1.7	-1.5
Glaucoma (self-reported)	1.3	1.5	4.8	2.2	2.1	0.3	1.8	-0.1	-1.1	0.3	0.6	-0.2	-1.7	-1.6	-0.1	0.3
Gout (self-reported)	0.3	0.4	2.5	-0.1	0.4	1.6	0.4	0.6	-0.6	0.1	-0.2	0.1	-0.1	-0.2	-1.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	5.1	0.5	1.1	-2.2	1.1	1.9	-0.5	-0.9	-0.1	1.1	-1.3	1.0	-0.2	-0.6
Medication: Amlodipine	1.1	1.6	5.2	0.6	-0.4	0.6	0.2	0.0	2.3	0.8	1.5	0.8	0.5	-1.6	1.9	2.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.9	1.0	-1.0	0.8	0.6	-0.3	0.2	-0.4	0.7	-0.2	0.8	-0.6	0.1
Birth weight	1.4	3.0	13.0	-0.6	-0.4	-0.7	-1.0	-1.6	-1.6	-3.6	-1.5	-1.1	-2.9	-1.1	-1.2	-2.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.5	2.3	1.3	-1.3	2.3	-0.6	1.2	1.1	-0.1	-1.2	0.6	-0.6	0.1	0.6
High blood pressure (siblings)	0.4	0.6	1.6	-1.2	-1.3	0.4	-1.0	-0.6	0.7	-0.8	0.3	-0.3	0.4	-1.1	-0.6	-0.6
Forced vital capacity (FVC), Best measure	2.0	7.3	13.0	-2.0	-2.4	1.1	-2.5	-3.6	-1.4	-2.8	-3.5	-3.1	-2.5	-3.4	-2.1	-3.2
Body fat percentage	0.3	1.1	3.8	-0.0	1.0	-1.1	0.5	1.2	-1.9	-0.4	-0.8	0.5	-1.9	1.1	-0.5	-0.9
Leg fat percentage (right)	0.3	1.2	2.9	0.6	1.7	-1.1	1.5	1.4	-1.2	1.0	0.3	0.8	-1.0	1.6	0.2	0.4
Arm fat-free mass (right)	0.6	3.1	10.7	-0.7	0.1	0.1	-0.3	-1.6	-2.8	-1.5	-1.7	-2.0	-3.3	-0.9	-1.8	-2.3
Exposure to tobacco smoke outside home	0.4	0.6	1.8	1.2	1.1	-0.9	0.7	-0.2	-0.9	0.3	-0.3	-0.9	-1.3	0.3	0.2	-0.2
Comparative body size at age 10	1.3	3.5	13.2	-1.7	-0.3	-0.7	-1.4	-0.1	-3.2	-2.1	-0.4	-0.4	-3.6	0.6	-2.5	-2.3
Number of full brothers	0.7	0.9	2.5	-1.6	-1.0	-0.5	-1.2	-0.6	-0.7	-1.4	-0.1	0.6	-1.1	-0.6	0.9	-0.8
Worry too long after embarrassment	1.2	1.9	8.2	-2.0	-2.9	-1.0	-2.3	-0.5	0.9	-2.0	-0.6	-0.4	-0.3	-0.5	0.3	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.4	1.8	2.1	-0.1	1.7	0.1	-1.9	0.2	-1.6	-0.7	0.2	0.6	-0.9	-0.5
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	1.4	1.4	-0.5	1.4	0.4	-1.1	-0.2	-0.2	-0.7	-1.0	0.9	-1.1	-0.8
Number of children fathered	0.6	0.7	3.1	-0.2	-0.1	1.2	-0.1	-1.7	0.1	-0.5	-0.2	-0.6	-0.8	-1.8	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.2	-0.5	-0.4	-0.5	-0.6	0.2	0.2	-0.8	-1.1	0.4	0.4	0.5	-0.3	-0.3
Age at first live birth	0.7	1.2	4.0	-1.7	-2.0	-0.3	-2.0	-0.7	-0.2	-1.5	-0.8	-0.1	-0.4	-0.5	0.3	-1.0
Pulse wave peak to peak time	1.5	1.8	6.9	1.4	0.9	-1.5	1.4	0.8	0.9	1.3	1.7	0.9	0.2	0.8	2.6	1.2
Health satisfaction	1.8	2.3	5.2	2.3	2.0	-1.2	2.2	0.9	1.5	0.2	2.3	1.4	0.1	0.7	1.7	1.2
Shortness of breath walking on level ground	0.7	0.8	2.8	0.9	1.0	0.7	1.1	-0.3	0.9	1.7	0.5	-0.3	0.7	0.0	0.4	1.5
Qualifications: College or University degree	0.6	2.0	4.0	-0.7	-1.2	1.3	-1.1	-1.2	-0.1	-2.0	-2.0	-2.0	0.4	-1.3	-1.9	-1.7
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.7	-0.1	1.1	-0.7	-0.6	-0.8	0.9	-0.4	0.1	0.2	0.5	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.7	-0.6	-0.9	0.3	-0.8	-1.6	0.0	-1.8	0.1	-0.2	-1.0	-1.9	-1.1	-1.0
Emphysema/chronic bronchitis	0.5	0.6	3.7	0.8	0.7	-0.5	0.7	-0.4	-0.1	-0.3	0.7	0.1	-0.5	-1.9	1.0	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	-1.2	-0.6	-0.7	-1.0	0.2	-0.3	-1.3	-0.5	0.1	-0.9	0.0	-0.1	-0.6
Neck or shoulder pain in last month	0.3	0.4	2.2	0.7	0.2	0.8	0.8	0.2	0.3	0.8	1.5	0.3	-0.1	0.0	0.0	0.6
Medication: Blood pressure	2.4	4.3	17.0	0.9	-0.4	0.3	0.8	0.7	4.1	1.9	1.8	2.1	3.1	-0.3	2.9	2.8
Angina (self-reported)	0.9	1.2	3.3	1.8	1.0	-0.7	1.8	0.4	0.8	1.2	1.0	0.8	1.5	0.1	1.1	0.6
Migraine (self-reported)	1.1	1.4	5.1	0.4	-0.0	1.1	0.1	-2.3	-1.3	-0.5	-1.1	-1.0	-1.0	-1.9	-1.4	-1.0
Medication: Ibuprofen	0.3	0.4	1.4	0.7	0.2	0.6	0.1	0.0	0.0	1.2	-0.9	-0.3	1.0	0.3	-0.4	0.2
Medication: Allopurinol	0.4	0.6	3.5	0.4	0.6	1.9	0.7	-0.0	-0.3	0.0	-0.5	-0.4	0.4	-1.1	-0.6	0.7
Medication: Omeprazole	0.4	0.5	2.2	0.1	-0.9	0.2	-0.3	-0.6	0.3	-0.1	0.6	-0.4	-1.3	-1.5	0.7	0.2
Medication: Seretide 50 evohaler	1.4	1.6	5.8	-1.2	-1.4	0.8	-1.1	-1.1	0.1	-1.8	-0.9	-0.9	-1.1	-2.4	-1.3	-0.6
Mean time to correctly identify matches	1.5	2.9	6.8	2.2	1.4	-0.0	1.9	-1.7	-1.2	-1.5	-1.5	-2.6	-2.1	-2.2	-0.9	-1.3
Heart disease (mother)	1.0	1.2	5.9	1.6	0.3	0.7	1.1	0.1	2.4	0.1	1.5	0.6	0.3	-1.1	0.2	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.5	12.9	0.5	0.1	0.7	0.3	2.1	2.6	1.2	2.5	2.9	3.6	1.0	2.7	3.0
Whole body fat mass	0.4	1.8	7.7	-0.5	0.8	-0.9	0.1	0.5	-2.6	-1.0	-1.4	-0.2	-2.8	0.6	-1.0	-1.6
Leg fat mass (right)	0.3	1.3	6.0	-0.3	1.1	-0.9	0.5	0.8	-2.4	-0.1	-0.6	0.1	-2.4	1.1	-0.6	-0.9
Arm predicted mass (right)	0.7	3.6	10.0	-0.6	0.2	0.3	-0.1	-1.9	-3.0	-1.6	-2.0	-2.5	-3.2	-1.1	-2.1	-2.4
Pulse rate, automated reading	0.3	1.1	5.0	0.4	1.3	-2.2	0.0	1.9	-0.8	-0.3	-0.7	0.6	-0.1	1.5	-0.1	-0.5
Alcohol intake frequency.	0.6	1.4	6.7	0.6	1.4	0.8	1.5	-0.4	-1.3	-0.3	-0.2	-1.7	-0.3	0.4	-2.6	-1.1
Comparative height size at age 10	0.1	0.4	1.1	-0.4	-0.9	-1.1	-0.6	0.7	0.0	-1.0	0.2	0.8	-0.7	-0.0	0.8	-0.1
Number of full sisters	0.2	0.2	0.8	-0.5	-0.2	0.9	-0.4	0.6	-0.5	-0.4	-0.1	0.8	0.3	0.1	-0.6	0.1
Suffer from ‘nerves’	0.8	1.3	6.8	0.3	-0.4	-2.6	0.4	1.7	0.7	-0.8	0.0	0.4	0.5	1.6	1.0	-1.1
Overall health rating	0.8	1.7	4.8	1.3	1.4	-1.2	1.4	2.2	0.9	-0.2	1.8	1.8	-0.5	1.1	0.5	0.9
Chest pain or discomfort	1.2	1.8	6.8	2.2	2.6	0.2	2.5	-1.4	-0.8	0.6	-0.1	-1.1	-0.5	-0.4	0.1	-0.2
Had major operations	0.5	0.6	3.1	0.4	1.0	0.4	0.5	0.1	-1.8	0.4	-0.8	-0.5	-0.3	0.6	-1.3	-0.5
Age at last live birth	0.2	0.2	1.1	0.7	-0.2	-0.5	0.7	0.3	0.4	-0.3	-0.5	-0.1	1.1	0.1	0.2	-0.3
Family relationship satisfaction	0.8	0.9	3.1	0.5	0.9	-1.8	1.0	0.7	0.4	1.3	0.7	0.2	1.1	0.7	1.3	0.9
Leg pain on walking	1.1	1.4	7.5	0.9	0.6	2.7	0.7	-0.1	1.1	0.7	1.3	0.2	0.3	-1.3	0.3	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	0.1	0.2	-1.0	0.2	0.6	-1.2	-0.1	-0.1	-0.8	-1.2	0.9	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.5	-0.5	-0.7	-1.3	-0.8	1.6	0.3	0.2	-0.1	0.6	-0.4	1.4	0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.4	-1.1	0.0	0.3	-0.7	0.8	-1.9	0.1	-0.3	-0.0	-0.6	1.4	-1.6	-0.8
Medication: Aspirin	0.3	0.3	1.5	0.2	-0.1	0.2	0.6	-0.7	0.2	0.2	-0.6	-1.1	1.2	0.1	-0.6	-0.1
Supplements: Vitamin C	1.5	1.8	4.5	1.6	2.1	0.9	1.7	0.6	-0.0	1.7	2.1	1.1	-0.1	0.1	0.4	1.8
Knee pain experienced in last month	1.8	2.8	11.6	3.2	3.1	0.0	3.4	0.7	-0.9	1.5	0.8	-0.3	-0.7	0.4	0.6	0.7
Hypertension (Self-reported)	0.5	1.3	6.5	0.5	-0.5	0.6	0.6	-1.4	2.3	0.1	0.1	0.1	1.1	-2.5	0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.8	1.4	1.8	1.5	1.3	-2.0	0.1	0.5	1.3	-0.4	0.0	-2.2	0.7	0.3
Illnesses of father: Heart disease	1.6	2.2	4.2	1.1	0.2	1.6	1.4	-1.4	2.0	1.4	1.5	0.1	1.8	-2.0	1.4	1.9
Illnesses of siblings: Diabetes	1.4	1.7	5.6	-0.7	-1.2	0.4	-0.7	-1.6	-0.8	-1.6	-0.6	-2.4	-1.0	-1.3	-1.8	-1.5
Smoking status: Previous	1.7	2.5	7.1	-1.9	-2.7	-0.4	-2.5	0.2	1.5	0.8	1.4	2.0	0.9	0.1	2.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	0.1	-0.7	-1.2	-0.6	0.6	-0.6	-1.4	-1.2	-0.2	-1.7	0.0	-0.4	-1.4
Whole body fat-free mass	0.8	4.4	15.7	-1.0	-0.0	-0.2	-0.5	-1.8	-3.2	-1.9	-2.1	-2.3	-4.0	-1.1	-2.2	-2.7
Leg fat-free mass (right)	0.9	4.8	17.7	-1.5	-0.3	-0.2	-1.3	-1.6	-3.6	-2.0	-2.1	-1.7	-4.2	-1.1	-2.2	-2.9
Arm fat percentage (left)	0.4	1.8	7.5	-0.9	0.5	-1.4	-0.3	1.1	-2.3	-0.9	-1.0	0.5	-2.7	1.0	-0.7	-1.4
Average weekly red wine intake	0.9	1.3	3.6	1.3	0.4	1.9	1.1	-0.4	1.4	0.6	1.0	0.5	1.6	-1.2	0.4	1.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.7	-0.3	-0.8	-1.4	-0.2	-0.7	-0.5	-0.9	-1.2	-1.2	-1.6	-0.1	-1.5	-1.3
Mood swings	0.6	1.0	2.0	1.4	1.2	-1.0	1.4	1.0	0.7	1.3	1.1	0.5	0.6	0.5	1.4	0.6
Loneliness, isolation	0.5	0.7	2.6	0.3	0.3	-1.2	0.2	1.0	-0.5	-0.3	1.6	-0.0	-1.3	0.5	1.2	-0.1
Long-standing illness, disability or infirmity	0.9	1.3	3.1	1.6	0.9	-1.5	1.5	1.3	1.3	0.9	0.2	0.0	1.7	0.8	0.6	0.9
Ever had bowel cancer screening	0.9	1.0	2.8	0.4	0.5	1.5	1.0	-1.4	-0.7	-0.7	-1.2	-1.1	0.9	-1.7	-0.6	-0.6
Diabetes diagnosed by doctor	1.3	2.1	5.2	-2.0	-2.2	-0.1	-1.8	-0.5	-0.4	-1.9	-2.3	-0.3	-0.5	-0.7	-1.5	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	1.1	0.7	0.0	0.8	-0.7	-0.7	-0.8	-0.9	-1.4	0.5	0.3	-0.2	-1.2
Friendships satisfaction	0.6	0.8	3.6	0.8	1.0	-0.2	1.2	0.4	0.3	0.6	0.5	0.4	1.9	-0.1	1.1	1.1
Qualifications: nursing, teaching	0.5	0.7	3.6	0.7	0.1	0.4	1.0	-0.2	1.4	0.7	-1.1	-0.1	1.9	-0.1	0.3	0.6
Commuting to job workplace: Walk	0.6	0.6	1.6	-0.1	1.0	0.1	0.6	-0.8	-1.1	-0.6	-1.3	-1.0	0.1	0.4	-1.1	-0.7
Eye problems/disorders: Cataract	0.6	0.7	2.7	-0.7	-1.7	0.4	-0.5	-0.7	0.5	-0.7	-0.6	-1.2	0.0	-1.0	-1.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	9.9	-0.2	-1.1	-1.7	-0.8	3.2	1.8	0.4	2.0	3.1	1.2	2.1	2.3	0.9
Medication for cholesterol	1.9	3.0	13.8	0.7	1.0	-1.5	0.4	3.4	-0.6	0.6	0.6	1.9	1.5	3.7	1.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	0.2	-0.1	-0.3	-0.1	0.6	0.9	1.1	0.5	0.4	0.2	0.9	0.2	1.1
Back pain experienced in last month	0.8	1.2	5.2	0.6	0.5	1.1	1.1	-1.2	0.4	0.4	-1.9	-2.3	0.5	-1.3	-0.2	-0.1
Mineral and other dietary supplements	1.0	1.3	4.5	0.5	0.9	0.6	1.0	1.5	1.5	0.6	0.5	1.3	2.1	0.4	1.2	1.4
Breast cancer (self-reported)	0.9	1.0	5.1	1.7	2.3	-0.5	1.9	-0.5	-0.1	0.3	-0.6	-0.7	0.1	-0.2	-0.4	-0.4
Asthma (self-reported)	1.3	2.6	6.8	0.8	-0.0	-2.2	0.3	2.6	1.6	0.2	1.8	2.1	0.9	2.6	1.6	1.1
Osteoporosis (self-reported)	1.4	1.7	5.0	-0.5	-0.0	0.3	-0.3	-1.5	-1.4	-0.9	-0.6	-2.1	-2.2	-1.7	-1.6	-1.0
Osteoarthritis (self-reported)	1.1	1.5	3.1	1.3	1.0	1.6	1.3	0.1	0.6	1.8	1.4	0.4	1.7	-0.7	0.9	1.6
Medication: Aspirin	0.3	0.4	1.5	0.7	0.3	0.2	1.1	-0.4	0.2	0.2	-0.5	-1.0	1.2	0.2	-0.2	0.0
Medication: Gliclazide	1.1	1.3	6.0	-0.4	-1.0	0.7	-0.4	-0.8	-0.6	-1.4	-1.7	-1.0	-0.2	-0.9	-2.4	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.2	4.3	-0.6	0.5	-0.7	-0.8	1.7	-1.6	0.0	-0.7	0.7	-0.8	2.1	-1.0	-0.9
Smoking status: Current	0.8	1.2	4.9	0.3	2.2	0.9	0.9	0.6	-2.0	0.5	-0.9	-0.0	-0.1	1.4	-1.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	10.7	-1.6	-2.1	1.6	-1.6	-3.3	0.5	-1.7	-1.7	-2.3	-0.1	-2.9	-1.1	-1.4
Whole body water mass	0.8	4.5	15.2	-1.1	-0.2	-0.2	-0.6	-1.8	-3.2	-2.0	-2.2	-2.3	-3.9	-1.1	-2.3	-2.8
Leg predicted mass (right)	0.9	4.8	17.3	-1.5	-0.4	-0.2	-1.3	-1.6	-3.6	-2.0	-2.1	-1.7	-4.2	-1.1	-2.1	-2.9
Arm fat mass (left)	0.6	2.3	10.8	-0.9	0.6	-1.1	-0.2	0.3	-2.9	-1.1	-1.5	-0.4	-3.3	0.5	-1.0	-1.9
Number of self-reported non-cancer illnesses	0.6	1.0	3.0	1.7	0.9	-0.7	1.7	0.1	1.0	0.1	0.4	0.7	0.2	-1.2	1.5	0.8
Average weekly champagne plus white wine intake	1.2	1.6	4.5	-0.7	-0.8	1.9	-0.5	-1.6	-0.2	-1.3	-1.1	-1.8	0.3	-2.1	-1.3	-0.8
Miserableness	0.5	0.9	2.4	1.4	0.8	-0.1	1.1	0.3	1.6	0.5	1.4	0.1	0.6	-0.3	1.4	1.1
Guilty feelings	0.4	0.6	3.3	-0.0	0.2	0.2	-0.1	-1.0	-0.4	-0.9	0.5	-0.4	-1.8	-0.9	0.9	-0.2
Wears glasses or contact lenses	0.7	0.8	2.3	-0.6	-0.4	0.6	-0.7	-1.3	-0.7	-1.5	-1.1	-0.8	-0.6	-1.0	-0.9	-0.9
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.9	0.6	-0.2	0.8	0.6	-0.8	0.5	-0.3	-0.4	0.6	0.6	-0.1	0.2
Hearing aid user	0.7	0.8	2.4	0.3	-0.5	-1.5	0.2	0.3	-0.9	-0.9	-1.4	-0.5	-0.3	0.3	-1.1	-1.3
Mother’s age at death	1.1	1.3	4.2	-0.7	-1.7	-1.7	-1.3	1.4	1.0	-0.9	0.7	2.0	0.5	0.6	0.5	0.1
Financial situation satisfaction	1.5	1.9	7.5	1.6	2.7	-0.1	2.1	1.1	-1.3	1.1	1.5	0.1	0.1	1.9	0.7	0.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	6.7	-0.9	-2.6	-0.4	-1.4	-0.5	0.1	-0.2	-0.8	-0.2	0.4	-1.1	-0.3	-0.2
Commuting to job workplace: Public transport	0.4	0.5	1.2	0.4	0.7	0.7	1.0	-1.0	-0.5	-1.1	-0.1	-1.1	0.0	-0.4	-0.9	-0.5
Eye problems/disorders: Glaucoma	1.2	1.4	5.4	2.3	2.0	-0.8	1.9	0.7	-0.5	0.3	1.1	0.3	-1.5	-0.7	0.5	0.3
Medication: Blood pressure	1.1	2.1	11.3	-0.6	-1.6	0.8	-0.4	-2.7	1.3	-0.2	-0.4	-1.5	-0.8	-3.4	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	1.7	2.1	9.7	0.5	0.7	1.8	0.9	-2.3	-0.3	0.7	-1.4	-3.1	-0.7	-1.6	-1.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.7	-0.9	-1.3	-0.7	-1.2	-1.0	-0.1	-0.5	0.3	-0.2	-1.6	-0.1	-0.4	-0.7
High cholesterol (Self-reported)	0.3	0.6	3.0	0.2	0.1	0.7	0.1	-0.6	-0.1	0.0	-0.6	-0.5	-1.7	-1.4	-1.0	-0.2
Medication: Bendroflumethiazide	1.8	2.7	7.7	1.3	-0.2	1.2	1.2	-0.1	2.8	0.9	1.8	1.6	1.3	-2.3	1.9	2.4
Medication: Paracetamol	0.4	0.6	1.6	1.3	0.9	1.1	0.9	-0.5	0.4	0.4	-0.3	-1.2	0.1	-0.9	0.1	-0.2
Medication: Lisinopril	1.3	1.7	5.2	1.0	0.0	0.3	1.0	0.3	1.9	1.7	1.5	0.4	2.3	0.2	1.9	1.6
Medication: Atorvastatin	0.4	0.6	2.3	-0.3	-0.9	-0.2	0.0	-1.2	0.0	-0.6	-0.8	-0.8	-0.1	-1.5	-0.2	-0.9
Illnesses of father: High blood pressure	0.6	0.8	2.9	-0.2	-1.1	0.3	-0.0	-1.6	0.8	0.0	-0.4	-1.7	1.0	-1.0	-0.0	-0.5
Alcohol drinker status: Never	1.3	1.5	5.3	1.2	2.3	0.3	1.7	-0.2	-2.1	0.1	-1.1	-0.8	-0.9	-0.4	-1.7	-0.4
Ever smoked	0.4	0.7	3.5	-1.5	-0.9	0.9	-1.9	-0.6	-0.5	0.1	0.2	0.3	-0.5	-0.0	0.0	-0.1
Basal metabolic rate	0.7	4.1	15.9	-0.9	0.2	-0.4	-0.3	-1.5	-3.3	-1.7	-2.0	-2.1	-4.0	-0.8	-2.1	-2.6
Leg fat percentage (left)	0.3	1.2	3.3	0.7	1.8	-1.0	1.5	1.4	-1.5	1.0	0.0	0.8	-1.1	1.5	0.3	0.2
Arm fat-free mass (left)	0.7	3.5	11.0	-0.4	0.7	-0.0	0.2	-1.7	-3.1	-1.3	-2.0	-2.4	-3.3	-0.8	-2.0	-2.4
Number of operations (self-reported)	1.0	1.5	3.4	1.6	1.6	1.8	1.9	-0.2	0.5	1.5	0.8	-0.6	1.0	-1.1	0.0	1.6
Average weekly beer plus cider intake	1.0	1.5	5.5	-0.3	0.2	-1.0	-0.4	0.7	-2.3	0.6	-2.3	-0.9	-0.9	1.4	-1.1	-1.4
Irritability	0.8	1.3	4.1	0.7	0.9	2.0	1.3	-1.8	-0.0	0.2	-0.5	-1.8	0.9	-1.0	-0.9	-0.2
Risk taking	0.3	0.5	1.6	-0.1	1.2	1.1	0.3	-0.1	-0.9	0.6	0.3	-0.7	0.2	0.9	-0.6	0.3
Ever had prostate specific antigen (PSA) test	1.2	1.4	6.7	-0.9	-2.6	0.9	-1.7	-0.3	1.4	-0.8	0.1	0.6	0.5	-1.6	-0.4	0.4
Fractured/broken bones in last 5 years	2.1	2.7	4.5	1.7	1.4	-1.4	1.6	2.0	1.9	2.0	0.4	1.5	2.1	1.3	1.6	1.8
Age started oral contraceptive pill	0.8	1.0	3.6	-0.5	-0.1	1.2	-0.4	-1.9	-0.5	-0.5	-0.2	-1.5	-0.8	-1.8	-0.9	-0.8
Diastolic blood pressure, automated reading	0.6	1.7	4.3	1.7	1.3	-1.6	2.0	0.8	2.1	0.9	0.9	0.3	1.6	0.4	1.0	0.9
Ever depressed for a whole week	1.5	1.8	7.9	0.3	-1.0	2.0	-0.1	-2.3	1.5	-0.6	-0.2	-0.5	1.4	-2.8	0.0	0.8
Unable to work because of sickness or disability	1.4	1.8	7.7	-0.9	-1.2	0.8	-0.8	-1.1	-0.2	-2.8	-1.8	-1.1	-1.3	-1.2	-1.4	-1.4
Commuting to job workplace: Cycle	0.6	0.7	2.6	0.8	0.1	0.9	0.4	-0.4	0.6	1.2	0.9	0.6	0.2	-1.3	0.8	1.6
Myopia	0.7	1.0	3.9	0.1	0.8	-2.0	0.5	1.9	-0.3	-0.3	-0.1	1.4	-0.2	1.1	0.7	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	7.5	-1.1	0.2	-0.1	-1.1	0.8	-2.7	-0.4	-0.7	-0.6	-1.6	1.8	-1.4	-1.3
Cholesterol lowering medication	0.6	0.9	4.7	-1.0	-0.8	-0.3	-0.7	-1.2	0.5	0.1	0.9	-0.3	-2.2	-1.6	0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.3	-0.0	-0.9	0.9	-0.5	-0.7	0.0	0.3	-0.0	-0.6	-0.5	-1.1	0.1	-0.2
Pain experienced in last month	0.3	0.5	2.3	-0.9	-1.1	-0.8	-1.5	-0.1	0.2	-0.7	0.1	0.9	0.9	-0.0	0.4	-0.1
Supplements: Calcium	0.5	0.6	2.6	-0.2	-0.7	-0.4	-0.5	-1.6	-0.0	0.0	0.2	-0.8	-0.8	-1.6	0.0	-0.1
Basal cell carcinoma (self-reported)	0.9	1.1	6.2	-0.5	0.4	2.5	0.0	-1.3	0.6	0.5	0.9	-0.2	-0.1	-1.7	-0.2	1.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.8	1.3	1.5	-0.7	1.6	0.2	1.4	1.7	0.9	0.4	2.2	1.5	1.9	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	3.2	0.1	-0.6	-0.1	0.4	0.5	1.8	0.3	1.1	0.8	0.2	-0.1	-0.1	0.6
Heart disease (siblings)	1.2	1.5	5.8	0.4	-0.4	1.4	0.3	-1.4	1.3	0.1	2.4	-0.2	-0.2	-2.3	-0.2	1.2
Alcohol drinker status: Previous	1.2	1.4	5.8	-0.5	-1.2	1.7	-0.5	-1.2	0.8	-0.1	0.1	-1.6	0.9	-1.2	-2.4	-0.2
Pack years of smoking	0.2	0.3	1.2	-0.1	0.6	0.8	0.3	-0.8	-0.8	0.3	0.2	-1.1	-0.6	-0.0	-0.3	-0.3
Impedance of whole body	0.6	2.8	8.7	1.9	0.1	-0.3	0.6	2.0	2.6	0.6	1.0	1.9	3.0	0.3	1.9	1.9
Leg fat mass (left)	0.3	1.4	5.8	-0.1	1.2	-1.0	0.5	0.9	-2.4	-0.1	-0.7	0.2	-2.4	1.1	-0.5	-0.9
Arm predicted mass (left)	0.6	3.3	11.3	-0.3	0.7	-0.3	0.3	-1.6	-2.9	-1.2	-1.8	-2.4	-3.4	-0.8	-1.8	-2.2