TWAS hub - SLC2A6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0348	0.0103	8.2e-06	0.027	0.014	0.017	0.021	0.025	2.7e-09	1.8e-05	1.5e-06	1.3e-07	1.2e-08
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0347	0.0194	6.2e-03	0.008	0.016	0.007	NA	0.012	3.9e-02	5.2e-03	4.7e-02	NA	1.3e-02
3	TCGA	Brain Lower Grade Glioma	0.0290	0.0169	4.5e-03	0.012	0.017	0.013	NA	0.008	1.5e-02	4.3e-03	1.0e-02	NA	3.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood clot in the leg (DVT)	15.1	19.5	23.8	-3.4	4.8	4.9
Deep venous thrombosis (DVT) (self-reported)	13.4	17.2	21.1	-3.1	4.6	4.6
Tinnitus: Yes, now most or all of the time	6.0	7.0	8.9	2.2	-2.7	-3.0
Eye problems/disorders: None of the above	4.8	5.6	9.1	3.0	-2.0	-1.9
Average weekly fortified wine intake	3.8	4.4	6.2	-2.5	2.3	1.4
Glaucoma (self-reported)	3.7	4.3	5.2	-2.3	1.8	2.2
Illnesses of father: Heart disease	3.6	5.0	8.7	-1.9	1.6	3.0
Impedance of arm (left)	3.3	15.3	20.3	-4.5	3.3	3.9
Primary Biliary Cirrhosis	3.2	4.5	7.3	1.7	-1.9	-2.7
Breast Cancer	3.1	7.4	11.6	1.4	-3.4	-2.9
Average weekly spirits intake	3.1	3.8	4.4	-2.1	2.1	1.6
Peak expiratory flow (PEF)	3.1	7.2	11.4	0.7	-3.4	-3.1
Eye problems/disorders: Glaucoma	3.1	3.7	4.4	-2.1	1.6	2.0
Impedance of arm (right)	3.0	14.0	21.0	-4.6	2.9	3.5
Blood Red Count	2.8	26.9	59.6	-0.4	-7.7	-4.6
Medication: Blood pressure	2.8	5.4	7.4	2.7	-1.8	-2.4
Diastolic blood pressure, automated reading	2.7	8.3	12.7	2.1	-2.8	-3.6
Financial difficulties in last 2 years	2.5	3.3	5.0	0.8	-2.2	-2.1
Impedance of whole body	2.5	12.7	18.4	-4.3	3.1	3.2
Cholesterol lowering medication	2.4	3.5	6.8	-0.9	1.7	2.6
Schizophrenia (2014)	2.3	5.0	15.1	3.9	0.0	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	5.8	1.5	-2.4	-1.6
High cholesterol (Self-reported)	2.3	4.1	6.6	-0.8	2.6	2.3
Allergy	2.2	5.1	7.4	1.5	-2.4	-2.7
Schizophrenia (2018)	2.1	4.3	12.8	3.6	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.0	-1.6	1.7	1.1
High blood pressure (siblings)	2.1	3.0	4.8	1.3	-1.6	-2.2
Arm fat-free mass (right)	2.1	10.7	14.0	3.0	-3.7	-3.0
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	4.3	-1.5	2.1	0.8
Trunk fat-free mass	2.0	11.3	15.4	3.0	-3.9	-3.1
Pulse wave reflection index	2.0	2.5	5.9	1.0	-0.8	-2.4
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	3.5	-1.9	1.5	1.4
Number of full sisters	2.0	2.4	3.1	1.7	-1.8	-1.1
Unable to work because of sickness or disability	2.0	2.6	3.7	1.2	-1.9	-1.7
Medication: Lansoprazole	1.9	2.1	3.0	1.2	-1.4	-1.7
Trunk predicted mass	1.9	10.9	14.9	2.9	-3.9	-3.0
Birth weight	1.9	4.2	5.8	-2.2	1.4	2.4
Eye problems/disorders: Cataract	1.9	2.2	2.9	-1.7	1.7	0.9
Alcohol drinker status: Previous	1.9	2.1	3.6	-1.6	0.3	1.9
HbA1C	1.8	2.0	6.0	-2.4	0.0	0.0
Crohns Disease (2017)	1.7	3.7	7.8	-2.8	1.6	0.9
Blood White Count	1.7	12.9	18.9	1.6	-4.2	-4.3
Mouth/teeth dental problems	1.7	2.6	3.9	1.9	-0.5	-2.0
Headache pain in last month	1.7	2.9	5.7	1.4	-1.1	-2.4
Arm predicted mass (right)	1.7	8.7	12.1	2.6	-3.5	-2.7
Whole body water mass	1.7	9.4	13.2	2.8	-3.6	-2.7
Arm fat-free mass (left)	1.7	8.5	11.0	2.7	-3.3	-2.7
Arm predicted mass (left)	1.7	8.7	11.9	2.5	-3.5	-2.8
Bipolar Disorder or Schizophrenia	1.6	3.8	11.4	3.4	0.0	0.0
Whole body fat-free mass	1.6	9.3	13.2	2.8	-3.6	-2.7
Basal metabolic rate	1.6	8.9	13.1	2.6	-3.6	-2.6
Irritable Bowel Disease (IBD)	1.5	3.7	7.1	-2.7	1.8	0.8
Ovarian Cancer	1.5	2.0	4.0	-0.0	-1.4	-2.0
High blood pressure	1.5	4.3	7.0	1.8	-1.6	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	9.4	0.4	-3.1	-2.3
Forced vital capacity (FVC), Best measure	1.5	5.6	11.2	-0.1	-3.3	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.0	0.8	-1.7	-1.5
Vascular/heart problems diagnosed by doctor	1.5	4.0	6.7	-1.7	1.6	2.6
Relative age voice broke	1.4	2.2	3.3	-0.3	1.8	1.8
Forced vital capacity (FVC)	1.4	5.4	9.3	-0.6	-3.0	-2.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	7.6	0.0	-2.8	-2.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	3.0	1.3	-1.5	-1.7
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.3	-1.1	1.8	1.1
Age at last live birth	1.4	2.1	4.7	1.2	-0.3	-2.2
Hypertension (Self-reported)	1.4	4.0	6.6	1.7	-1.6	-2.6
Hearing aid user	1.4	1.6	2.0	-1.1	1.3	1.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.7	-0.3	1.5	1.6
Weight	1.3	6.5	10.5	2.2	-3.2	-2.0
Alcohol intake versus 10 years previously	1.3	2.0	4.5	1.2	0.0	-2.1
Length of working week for main job	1.3	1.4	2.9	0.9	0.7	1.7
Leg fat-free mass (right)	1.3	6.8	10.7	2.4	-3.3	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.8	1.1	-2.2	-1.5
Cardiovascular Disease	1.2	4.1	5.6	2.0	-1.6	-2.4
Angina	1.2	1.6	2.8	0.4	-1.7	-1.3
Impedance of leg (right)	1.2	5.9	11.9	-3.4	1.9	1.5
High blood pressure (mother)	1.2	1.7	3.3	0.5	-1.2	-1.8
Medication: Simvastatin	1.2	1.8	2.9	-1.7	1.4	0.8
Illnesses of siblings	1.2	1.8	2.5	-1.3	1.6	1.0
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.1	1.4	-1.1	-0.8
Loneliness, isolation	1.2	1.7	4.2	-2.1	0.2	0.9
Leg predicted mass (right)	1.2	6.7	10.6	2.4	-3.2	-1.9
Financial situation satisfaction	1.2	1.5	2.5	0.6	-1.6	-1.3
Ulcerative Colitis (UC)	1.1	2.1	3.4	-1.9	1.5	0.7
Hypothyroidism (self reported)	1.1	2.5	3.7	1.9	-1.5	-1.2
Vitamin and mineral supplements	1.1	1.5	2.6	-1.2	0.7	1.6
Leg fat-free mass (left)	1.1	5.9	9.5	2.2	-3.1	-1.9
Hand grip strength (right)	1.1	3.0	4.4	2.0	-0.9	-2.1
Leg predicted mass (left)	1.1	6.0	9.6	2.2	-3.1	-1.9
Heart attack	1.1	1.4	2.7	-1.2	0.4	1.6
Worrier / anxious feelings	1.1	2.0	3.8	0.9	-1.2	-1.9
Medication: Amlodipine	1.1	1.5	2.2	1.5	-0.1	-1.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	-1.1	-0.3	1.6
Angina (self-reported)	1.1	1.4	2.4	0.3	-1.5	-1.4
Wears glasses or contact lenses	1.1	1.3	3.1	1.8	0.1	0.8
Medication: Atorvastatin	1.1	1.4	3.6	0.0	0.7	1.9
Commuting to job workplace: Cycle	1.1	1.3	2.1	-1.3	-0.3	1.5
Alzheimer’s Disease (in mother)	1.0	1.2	3.3	0.4	-1.8	-0.2
Fed-up feelings	1.0	1.8	2.2	-1.3	1.3	1.5
Chronic bronchitis/emphysema (father)	1.0	1.1	3.3	-1.8	0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.3	1.8	-1.3	-0.9
Pulse rate, automated reading	1.0	3.3	6.7	1.0	-2.6	-1.4
Leg fat percentage (left)	1.0	3.4	5.8	1.0	-2.4	-1.9
Average weekly beer plus cider intake	1.0	1.4	1.8	1.3	-0.9	-1.2
Heart disease (siblings)	1.0	1.2	2.3	-0.2	-1.1	1.5
Leg fat mass (left)	1.0	4.0	7.3	1.1	-2.7	-1.9
Schizophrenia vs Biploar Disorder	0.9	1.2	3.7	1.9	0.0	0.0
Pack years adult smoking proportion	0.9	1.4	2.5	-0.3	1.6	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.0	1.5	-0.5	-2.0
Body mass index (BMI)	0.9	3.9	4.6	2.1	-2.1	-1.7
Impedance of leg (left)	0.9	4.5	10.3	-3.2	1.4	1.2
Waist circumference	0.9	3.2	5.4	1.7	-2.3	-1.1
Age at first live birth	0.9	1.6	3.7	0.8	-0.7	-1.9
Medication: Blood pressure	0.9	1.6	3.3	0.4	-1.2	-1.8
Medication: Seretide 50 evohaler	0.9	1.1	2.7	1.6	-0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.7	-0.3	1.2	1.3
Supplements: Vitamin C	0.9	1.1	1.7	1.3	-0.0	-1.2
Fractured/broken bones in last 5 years	0.9	1.1	3.0	-0.3	0.5	1.7
Ever depressed for a whole week	0.9	1.1	1.7	0.4	-1.1	-1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.5	-1.0	0.2	1.6
Alzheimer’s Disease (including proxy)	0.8	1.1	2.9	0.4	-1.7	-0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.5	1.6	-0.3	-0.7
Townsend deprivation index at recruitment	0.8	1.1	3.1	1.8	-0.4	-0.5
Supplements: Glucosamine	0.8	1.0	2.7	-1.6	0.4	-0.3
Nervous feelings	0.8	1.4	2.0	0.9	-1.4	-1.2
Father’s age at death	0.8	1.1	1.7	1.3	-0.9	-0.9
Pulse rate	0.8	1.3	3.7	-0.4	-1.9	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	0.5	0.5	-1.5
Lung cancer (father)	0.8	0.9	1.0	-0.9	-0.9	-1.0
Mean time to correctly identify matches	0.8	1.6	2.6	1.6	-0.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	-1.1	0.1	-1.3
Leg fat mass (right)	0.8	3.2	6.0	0.8	-2.5	-1.7
Leg pain on walking	0.8	1.1	2.9	-1.7	0.5	0.3
Breast cancer (self-reported)	0.8	1.0	2.0	0.1	1.0	1.4
Medication: Aspirin	0.8	1.0	1.7	-1.3	1.1	-0.1
Alcohol drinker status: Never	0.8	1.0	2.3	-0.3	-0.7	-1.5
Pack years of smoking	0.8	1.2	2.2	-0.5	1.5	1.1
Lung FVC	0.7	3.3	7.3	0.6	-2.7	-1.5
Supplements: Zinc	0.7	0.8	1.9	0.6	0.1	-1.4
Current tobacco smoking	0.7	1.2	1.4	-0.8	1.2	1.2
Medication: Levothyroxine sodium	0.7	1.2	2.4	1.5	-0.6	-0.9
Hair/balding pattern: Pattern 2	0.7	1.0	1.2	1.1	-1.1	-0.6
Diabetes (self-reported)	0.7	1.0	1.5	-1.2	0.8	1.0
Hip circumference	0.7	2.9	6.6	1.2	-2.6	-0.9
Medication: Cholesterol lowering	0.7	1.1	1.7	-1.1	1.3	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.1	-0.4	1.4	-0.2
Leg fat percentage (right)	0.7	2.4	3.9	0.6	-2.0	-1.7
Heart disease (mother)	0.7	0.9	1.4	1.2	-1.0	-0.4
Suffer from ‘nerves’	0.7	1.1	1.3	1.1	-1.1	-1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.4	0.0	0.2	1.5
Medication: Aspirin	0.7	0.9	1.8	-1.3	0.9	0.0
Age started oral contraceptive pill	0.7	0.8	1.5	-0.4	1.2	0.9
Triglycerides	0.6	1.0	2.9	1.7	0.0	0.0
Heel T-Score	0.6	5.0	10.1	1.3	-1.8	-3.2
BMI	0.6	3.3	4.8	2.2	-2.0	-1.1
Hand grip strength (left)	0.6	1.5	4.0	0.7	-0.3	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	-1.2	0.5	0.7
Medication: Atenolol	0.6	0.8	1.3	1.1	-1.0	-0.3
Sitting height	0.6	4.1	9.2	0.4	-3.0	-1.7
Past tobacco smoking	0.6	1.0	2.3	-1.5	0.7	0.5
Had other major operations	0.6	0.7	1.6	-1.3	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.1	0.9	-0.4	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.4	1.2	-0.3	-0.9
Medication: Ramipril	0.6	0.8	1.3	0.6	-1.2	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.1	1.1	0.9	0.8
Number of live births	0.6	0.8	2.3	1.5	-0.1	-0.4
Illnesses of mother	0.6	0.8	1.1	0.5	1.0	1.0
Loud music exposure frequency	0.6	0.7	1.1	-0.1	0.9	1.0
Qualifications: nursing, teaching	0.6	0.9	1.6	0.6	-1.3	-0.9
Back pain experienced in last month	0.6	0.9	1.8	0.5	-0.8	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	0.0	-0.9	-1.3
Number of operations (self-reported)	0.6	0.8	2.1	-0.6	0.2	1.5
Crohns Disease (2012)	0.5	0.8	2.4	-1.6	0.0	0.0
HDL Cholesterol	0.5	0.8	2.3	-1.5	0.0	0.0
Asthma	0.5	1.1	2.8	1.7	-0.6	-0.4
Prospective memory result	0.5	0.6	1.7	1.3	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	0.4	0.4	1.4
Migraine (self-reported)	0.5	0.6	1.3	-0.5	-0.6	-1.1
Medication: Ibuprofen	0.5	0.7	1.7	-1.3	-0.0	0.5
Medication: Allopurinol	0.5	0.7	1.8	-1.4	0.2	-0.3
Medication: Omeprazole	0.5	0.7	1.4	1.2	-0.3	-0.7
Friendships satisfaction	0.5	0.6	1.1	-1.1	0.4	0.7
Mineral and other dietary supplements	0.5	0.6	1.2	0.7	0.5	1.1
Asthma (self-reported)	0.5	1.0	2.7	1.6	-0.5	-0.3
Osteoporosis (self-reported)	0.5	0.7	1.3	-0.4	0.8	1.1
Medication: Gliclazide	0.5	0.5	1.3	0.2	0.5	1.1
Arm fat mass (left)	0.5	2.0	3.8	1.0	-1.9	-1.1
Illnesses of father: High blood pressure	0.5	0.6	1.3	0.1	-1.1	-0.8
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	-1.1	0.4	-0.6
Mean Putamen Volume	0.4	0.5	1.1	-1.1	0.5	0.1
Systolic Blood Pressure	0.4	1.9	3.7	1.4	0.1	-1.9
Sensitivity / hurt feelings	0.4	0.7	1.4	-1.2	-0.7	-0.5
Diabetes (father)	0.4	0.5	1.1	-1.0	0.5	-0.4
Diabetes (mother)	0.4	0.6	1.6	-1.3	0.1	-0.1
Age when periods started (menarche)	0.4	1.0	1.6	-1.2	1.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.6	0.6	-0.8	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.7	1.0	0.3
Multivitamins +/- minerals	0.4	0.5	1.0	0.5	-0.4	-1.0
Noisy workplace	0.4	0.5	1.0	0.0	-1.0	-0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-1.5	0.6	0.6
Gout (self-reported)	0.4	0.6	0.9	-0.2	0.9	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	1.0	-0.6	-0.5
Comparative body size at age 10	0.4	1.2	1.2	1.0	-1.1	-1.1
Knee pain experienced in last month	0.4	0.7	1.0	0.7	-0.7	-1.0
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.3	-0.8	-0.9
Smoking status: Previous	0.4	0.7	1.2	1.1	-0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	-0.3	-0.5	-1.0
Osteoarthritis (self-reported)	0.4	0.5	1.2	-0.3	1.1	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	1.1	0.0	-0.3
Commuting to job workplace: Public transport	0.4	0.5	0.6	-0.5	0.7	0.8
Ever smoked	0.4	0.7	1.4	1.2	0.9	-0.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	-1.0	1.3	0.5
Neuroticism (Nagel 2018)	0.3	0.7	0.8	-0.8	-0.7	-0.9
Worry (Nagel 2018)	0.3	0.7	1.2	0.2	-0.9	-1.1
Reaction Time	0.3	0.6	1.5	1.2	-0.2	-0.6
Ulcerative Colitis	0.3	0.4	1.2	-1.1	0.0	0.0
Blood Eosinophil Count	0.3	2.4	5.5	-0.2	-1.3	-2.4
Blood Platelet Count	0.3	3.9	11.1	0.7	3.3	-0.3
Chronotype (morning person)	0.3	0.7	1.8	-1.4	-0.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.3	0.1	0.9
Had menopause	0.3	0.4	0.6	0.7	-0.2	0.8
Pain all over the body in last month	0.3	0.3	0.8	0.9	0.2	0.4
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-0.6	0.5	1.0
Arm fat mass (right)	0.3	1.3	2.5	0.8	-1.6	-0.9
Medication: Paracetamol	0.3	0.5	1.0	-0.1	-0.6	-1.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	-0.5	1.2	0.3
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.3	-1.0	-0.3
Whole body fat mass	0.3	1.1	2.8	0.2	-1.7	-0.7
Alcohol intake frequency.	0.3	0.8	1.3	-0.9	-0.4	-1.1
Comparative height size at age 10	0.3	1.7	4.3	-0.5	-2.1	-0.7
Chest pain or discomfort	0.3	0.5	0.8	-0.9	-0.7	-0.2
Had major operations	0.3	0.4	0.8	0.9	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	0.8	-0.7	0.2
Ever had bowel cancer screening	0.3	0.4	1.2	-0.1	0.1	1.1
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.8	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.8	-0.1	0.7
Smoking status: Current	0.3	0.5	0.7	-0.5	0.8	0.8
Mother’s age at death	0.3	0.4	1.1	-1.0	-0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.1	-0.9	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.2	1.1	0.0	-0.5
Irritability	0.3	0.6	1.2	-1.1	0.7	0.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-0.1	-0.4	-1.0
Pain experienced in last month	0.3	0.5	1.0	-0.5	0.3	1.0
Bipolar Disorder (2018)	0.2	0.3	0.9	0.9	0.0	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-1.0	-0.5	-0.5
Depression (Nagel 2018)	0.2	0.4	1.0	-1.0	-0.1	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.8	-0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	-0.9	0.9	0.1
Age at First Birth	0.2	0.3	1.0	-1.0	0.0	0.0
Lupus	0.2	0.3	0.5	0.7	-0.6	-0.4
Neuroticism (2016)	0.2	0.4	0.6	0.2	-0.7	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.7	0.0	0.0
Height	0.2	3.9	11.0	0.1	-3.3	-0.9
Respiratory disease	0.2	0.4	0.8	0.4	0.9	0.7
Neuroticism	0.2	0.4	1.1	-1.1	0.3	-0.1
Number of treatments/medications taken	0.2	0.4	0.8	-0.9	0.5	-0.4
Relative age of first facial hair	0.2	0.4	0.9	1.0	0.0	-0.4
Systolic blood pressure, automated reading	0.2	0.7	1.8	0.3	1.3	-0.3
Medication for hormone replacement therapy	0.2	0.3	0.4	-0.6	0.3	0.6
Medication: Metformin	0.2	0.3	0.6	0.8	0.3	-0.5
Severe depression (siblings)	0.2	0.2	0.4	-0.5	0.3	-0.6
Trunk fat percentage	0.2	0.8	1.7	-1.3	-0.2	0.7
Maternal smoking around birth	0.2	0.3	0.9	0.3	-0.0	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.1	0.6	0.9
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.1	-0.7	-0.3
Trunk fat mass	0.2	0.7	2.1	-0.2	-1.4	-0.3
Number of incorrect matches in round	0.2	0.3	0.5	0.7	0.1	0.5
Falls in the last year	0.2	0.3	0.6	-0.8	0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	1.0	-0.0	-0.7
Depression (self-reported)	0.2	0.2	0.3	0.6	-0.3	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.2	-0.4	-0.7
Standing height	0.2	2.1	5.7	0.2	-2.4	-0.9
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.0	-0.6	-0.6
Number of full brothers	0.2	0.3	0.5	0.5	-0.7	-0.3
Worry too long after embarrassment	0.2	0.4	1.2	-1.1	-0.1	0.1
Shortness of breath walking on level ground	0.2	0.3	0.9	-0.0	0.1	-0.9
Qualifications: College or University degree	0.2	0.6	1.4	1.2	-0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.4	-0.0
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.4	0.6	0.7
Medication for cholesterol	0.2	0.3	0.5	0.0	-0.7	-0.5
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	-0.2	0.7	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.5	0.4	0.6
Miserableness	0.2	0.4	0.8	0.1	-0.9	-0.6
Medication: Paracetamol	0.2	0.3	0.5	-0.6	-0.7	-0.1
Risk taking	0.2	0.3	0.8	0.3	-0.3	-0.9
Myopia	0.2	0.3	0.7	0.2	-0.8	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.7	-0.2	-0.5
Supplements: Calcium	0.2	0.2	0.5	-0.2	0.7	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.6	0.0	0.0
Fasting Glucose	0.1	0.1	0.3	0.5	0.0	0.0
LDL Cholesterol	0.1	0.2	0.5	-0.7	0.0	0.0
Rheumatoid Arthritis	0.1	0.2	0.6	-0.8	0.0	0.0
Allergy or Eczema	0.1	0.2	0.3	-0.3	0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	0.2	-0.7	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.5	-0.5	-0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.3	-0.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.4	-0.3	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.5	0.2	0.3
Taking other prescription medications	0.1	0.2	0.4	-0.7	0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.2	-0.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	0.5	-0.3
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	-0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.3	0.4	0.3
Neuroticism score	0.1	0.1	0.3	-0.6	0.1	-0.3
Time employed in main current job	0.1	0.1	0.3	0.0	0.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	-0.5	0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.5	-0.0	-0.2
Breastfed as a baby	0.1	0.1	0.2	0.5	-0.4	0.3
Tense / ‘highly strung’	0.1	0.2	0.4	-0.6	-0.4	-0.4
Birth weight of first child	0.1	0.1	0.2	-0.3	-0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.6	-0.5	0.3
Body fat percentage	0.1	0.3	0.5	-0.6	-0.7	-0.1
Number of children fathered	0.1	0.1	0.2	0.2	-0.1	-0.4
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	0.0	0.4
Health satisfaction	0.1	0.1	0.2	-0.3	0.2	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	0.4	0.2
Overall health rating	0.1	0.2	0.4	0.7	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.7	0.3	-0.6
Mood swings	0.1	0.2	0.3	0.1	-0.4	-0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.3	-0.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.4	-0.1	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	0.4	-0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.1	0.1	-0.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.0	0.1	0.3	0.1	-0.2
Smoking Status	0.0	0.0	0.1	-0.2	0.1	-0.2
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.5	-0.1	0.2
Hair Pigment	0.0	1.2	1.6	1.3	-1.2	-0.7
Tanning	0.0	0.5	0.8	-0.6	0.9	0.5
Medication: Co-codamol	0.0	0.0	0.0	0.0	-0.2	-0.0
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.1	-0.3	0.3
Qualifications: None of the above	0.0	0.1	0.1	0.2	-0.1	0.3
Fluid intelligence score	0.0	0.1	0.2	-0.1	0.1	-0.4
Arm fat percentage (right)	0.0	0.2	0.4	0.0	-0.7	-0.2
Happiness	0.0	0.0	0.0	0.1	0.0	0.2
Family relationship satisfaction	0.0	0.0	0.0	0.2	-0.2	-0.2
Arm fat percentage (left)	0.0	0.1	0.4	0.0	-0.6	0.0
Average weekly red wine intake	0.0	0.1	0.1	-0.2	0.3	0.2
Guilty feelings	0.0	0.1	0.1	-0.1	-0.2	0.3

Hub : Genes

SLC2A6

Models

Trait associations